GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Mthfr | multiple interactions | EXP | | 6480464 | CTD | [Folic Acid co-treated with Vitamin B 12 deficiency] results in decreased expression of MTHFR mRNA; Folic Acid inhibits the reaction [phenylhydrazine results in decreased activity of MTHFR protein] | PMID:25003120 PMID:33788065 | Mthfr | affects abundance | ISO | MTHFR (Homo sapiens) | 6480464 | CTD | MTHFR gene polymorphism affects the abundance of Folic Acid; MTHFR gene SNP affects the abundance of Folic Acid | PMID:16621645 PMID:16690736 PMID:21869730 | Mthfr | affects expression | ISO | MTHFR (Homo sapiens) | 6480464 | CTD | Folic Acid affects the expression of MTHFR mRNA | PMID:17311948 | Mthfr | affects metabolic processing | ISO | MTHFR (Homo sapiens) | 6480464 | CTD | MTHFR gene polymorphism affects the metabolism of Folic Acid; MTHFR protein affects the metabolism of Folic Acid | PMID:20532609 PMID:20547447 | Mthfr | affects response to substance | ISO | Mthfr (Mus musculus) | 6480464 | CTD | MTHFR protein affects the susceptibility to Folic Acid | PMID:25733650 | Mthfr | decreases abundance | ISO | MTHFR (Homo sapiens) | 6480464 | CTD | MTHFR gene mutant form results in decreased abundance of Folic Acid | PMID:17115185 | Mthfr | decreases activity | ISO | Mthfr (Mus musculus) | 6480464 | CTD | Folic Acid results in decreased activity of MTHFR protein | PMID:25733650 | Mthfr | decreases methylation | ISO | MTHFR (Homo sapiens) | 6480464 | CTD | Folic Acid results in decreased methylation of MTHFR promoter | PMID:29644877 | Mthfr | multiple interactions | ISO | Mthfr (Mus musculus) | 6480464 | CTD | [Choline deficiency co-treated with Folic Acid deficiency co-treated with Methionine deficiency] results in increased expression of MTHFR mRNA; [Choline deficiency co-treated with Folic Acid deficiency] affects the expression of MTHFR mRNA; [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MTHFR mRNA; Folic Acid inhibits the reaction [AGT protein results in decreased expression of MTHFR mRNA]; Folic Acid inhibits the reaction [AGT protein results in decreased expression of MTHFR protein]; Folic Acid inhibits the reaction [Methotrexate results in decreased expression of MTHFR mRNA] | PMID:20938992 PMID:23439872 PMID:24386282 PMID:29127188 PMID:30502384 | Mthfr | multiple interactions | ISO | MTHFR (Homo sapiens) | 6480464 | CTD | [Folic Acid co-treated with MTHFR gene SNP] affects the methylation of MGMT promoter; Folic Acid inhibits the reaction [MTHFR gene polymorphism results in increased activity of ACHE protein]; MTHFR gene polymorphism affects the reaction [Folic Acid affects the methylation of CDKN2A promoter] | PMID:16375580 PMID:16646054 PMID:17301267 | |
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