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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309952
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mthfr
Name: methylenetetrahydrofolate reductase
Acc ID: CHEBI:27470
Term: folic acid
Definition: An N-acyl-amino acid that is a form of the water-soluble vitamin B9. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosynthesis and homocysteine remethylation.
Chemical ID: MESH:D005492
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mthfrmultiple interactionsEXP 6480464CTD[Folic Acid co-treated with Vitamin B 12 deficiency] results in decreased expression of MTHFR mRNA; Folic Acid inhibits the reaction [phenylhydrazine results in decreased activity of MTHFR protein]PMID:25003120 PMID:33788065
Mthfraffects abundanceISOMTHFR (Homo sapiens)6480464CTDMTHFR gene polymorphism affects the abundance of Folic Acid; MTHFR gene SNP affects the abundance of Folic AcidPMID:16621645 PMID:16690736 PMID:21869730
Mthfraffects expressionISOMTHFR (Homo sapiens)6480464CTDFolic Acid affects the expression of MTHFR mRNAPMID:17311948
Mthfraffects metabolic processingISOMTHFR (Homo sapiens)6480464CTDMTHFR gene polymorphism affects the metabolism of Folic Acid; MTHFR protein affects the metabolism of Folic AcidPMID:20532609 PMID:20547447
Mthfraffects response to substanceISOMthfr (Mus musculus)6480464CTDMTHFR protein affects the susceptibility to Folic AcidPMID:25733650
Mthfrdecreases abundanceISOMTHFR (Homo sapiens)6480464CTDMTHFR gene mutant form results in decreased abundance of Folic AcidPMID:17115185
Mthfrdecreases activityISOMthfr (Mus musculus)6480464CTDFolic Acid results in decreased activity of MTHFR proteinPMID:25733650
Mthfrdecreases methylationISOMTHFR (Homo sapiens)6480464CTDFolic Acid results in decreased methylation of MTHFR promoterPMID:29644877
Mthfrmultiple interactionsISOMthfr (Mus musculus)6480464CTD[Choline deficiency co-treated with Folic Acid deficiency co-treated with Methionine deficiency] results in increased expression of MTHFR mRNA; [Choline deficiency co-treated with Folic Acid deficiency] affects the expression of MTHFR mRNA; [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MTHFR mRNA; Folic Acid inhibits the reaction [AGT protein results in decreased expression of MTHFR mRNA]; Folic Acid inhibits the reaction [AGT protein results in decreased expression of MTHFR protein]; Folic Acid inhibits the reaction [Methotrexate results in decreased expression of MTHFR mRNA]PMID:20938992 PMID:23439872 PMID:24386282 PMID:29127188 PMID:30502384
Mthfrmultiple interactionsISOMTHFR (Homo sapiens)6480464CTD[Folic Acid co-treated with MTHFR gene SNP] affects the methylation of MGMT promoter; Folic Acid inhibits the reaction [MTHFR gene polymorphism results in increased activity of ACHE protein]; MTHFR gene polymorphism affects the reaction [Folic Acid affects the methylation of CDKN2A promoter]PMID:16375580 PMID:16646054 PMID:17301267
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