FOLATE MEDIATED ONE-CARBON METABOLIC PATHWAY (PW:0000189)

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Description

Tetrahydrofolates (THF) are soluble forms of vitamin B9 that play essential roles in a number of metabolic pathways by mediating the transfer of 1-carbon (1C) units for the de novo synthesis of purines and thymidylates and for the re-methylation of homocysteine (Hcy) to methionine (Met). Humans cannot synthesize folate and must derive it from diet or as a supplement in the form of folic acid (FA). The folate/FA consist of three moieties: a pterin (pteridine) ring, a para aminobenzoyl group (PABA

Pathway Diagram:

Ariadne Genomics Inc. homocysteine ---> methionine homocysteine 5-methyl-THF S-adenosylmethionine methionine Cbl 5-methyl-THF ---> THF 10-formyl-THF ---> de novo purine biosynthetic pathway ADP <--> ATP THF DHF <--> THF 5,10-methylene-THF <--> THF PLP/B6 DHF <--> 5,10-methylene-THF dTMP <--> dUMP 10-formyl-THF <--> THF NADP+ NADPH FAD dUMP dTMP DHF 5,10-methylene-THF ---> 5-methyl-THF formate Dhfr Shmt2 Shmt1 Tyms Atic Gart folate cycle metabolic pathway 5,10-methylene-THF <--> 10-formyl-THF methyl group transfer  to carbon, nitrogen, oxygen or sulfur atoms on proteins, nucleic acids, carbohydrates, lipids, small molecules methionine cycle/metabolic pathway 5,10-methylene-THF DNA synthesis, DNA repair dTMP ---> DNA synthesis, DNA repair Mthfr Mtr Mtrr Mtrr ---> Mtr 10-formyl-THF de novo purine biosynthetic pathway remethylation pathway of homocysteine metabolism - cobalamin dependent remethylation pathway of homocysteine metabolism - cobalamin dependent <--> methionine cycle/metabolic pathway ATP ADP NADPH ---> NADP+ Mthfd1 formate ---> 10-formyl-THF
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folate mediated one-carbon metabolic pathway term browser
Symbol Object Name GBrowse Chr Start Stop Reference
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 GBrowse link 4 186,990,816 187,030,955 RGD:1547843
RGD:6907045
G Aldh1l2 aldehyde dehydrogenase 1 family, member L2 GBrowse link 7 26,506,321 26,555,206 RGD:6907045
G Amt aminomethyltransferase GBrowse link 8 116,421,237 116,427,437 RGD:6907045
G Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase GBrowse link 9 78,636,339 78,656,387 RGD:70804
RGD:6907045
RGD:7242561
G Dhfr dihydrofolate reductase GBrowse link 2
2
41,137,784
41,162,308
41,149,417
41,162,496
RGD:1298877
RGD:6907045
RGD:7242561
G Dmgdh dimethylglycine dehydrogenase GBrowse link 2 42,469,950 42,545,633 RGD:1547831
G Folh1 folate hydrolase 1 GBrowse link 1 156,631,301 156,702,948 RGD:728645
G Ftcd formimidoyltransferase cyclodeaminase GBrowse link 20 14,965,126 14,978,635 RGD:6907045
G Gart phosphoribosylglycinamide formyltransferase GBrowse link 11 35,389,216 35,414,461 RGD:1547842
RGD:6907045
RGD:7242561
G Ggh gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) GBrowse link 5 38,693,591 38,716,702 RGD:69845
G Gnmt glycine N-methyltransferase GBrowse link 9 15,471,889 15,475,241 RGD:1545057
G Mtfmt mitochondrial methionyl-tRNA formyltransferase GBrowse link 8 70,644,131 70,674,636 RGD:6907045
G Mthfd1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase GBrowse link 6 108,694,405 108,761,922 RGD:1299513
RGD:6907045
RGD:7242561
G Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like GBrowse link 1 41,876,363 42,065,394 RGD:6907045
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase GBrowse link 4 179,592,799 179,604,331 RGD:1540378
RGD:6907045
G Mthfd2l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like GBrowse link 14 18,548,222 18,629,209 RGD:6907045
G Mthfr methylenetetrahydrofolate reductase (NAD(P)H) GBrowse link 5 168,502,556 168,522,350 RGD:1535021
RGD:6907045
RGD:7242561
G Mthfs 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase) GBrowse link 8 96,071,796 96,121,086 RGD:6907045
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase GBrowse link 17 67,954,893 68,041,488 RGD:1359026
RGD:6907045
RGD:7242426
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase GBrowse link 1 39,124,730 39,156,109 RGD:7242426
G RGD1564040 similar to methylenetetrahydrofolate dehydrogenase (NAD) (EC 1.5.1.15)/methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) precursor GBrowse link 5 124,738,251 124,739,298 RGD:6907045
G Sardh sarcosine dehydrogenase GBrowse link 3 11,100,670 11,164,367 RGD:634034
G Shmt1 serine hydroxymethyltransferase 1 (soluble) GBrowse link 10 46,802,986 46,831,051 RGD:1359815
RGD:2300383
RGD:6907045
RGD:7242561
G Shmt2 serine hydroxymethyltransferase 2 (mitochondrial) GBrowse link 7 70,998,103 71,003,197 RGD:1359815
RGD:2300383
RGD:6907045
RGD:7242561
G Tyms thymidylate synthetase GBrowse link 9 121,368,418 121,381,493 RGD:1545055
RGD:6907045
RGD:7242561
altered folate mediated one-carbon metabolic pathway term browser
Symbol Object Name GBrowse Chr Start Stop Reference
G Mthfd1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase GBrowse link 6 108,694,405 108,761,922 RGD:7242562
G Mthfr methylenetetrahydrofolate reductase (NAD(P)H) GBrowse link 5 168,502,556 168,522,350 RGD:7242562
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase GBrowse link 17 67,954,893 68,041,488 RGD:7242562

Altered Pathway:

References Associated with the folate mediated one-carbon metabolic pathway:

Ontology Path Diagram:

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