Imported Disease Annotations - CTDTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Weight Gain | | ISO | DYNC1LI2 (Homo sapiens) | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:19030233 | |
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Imported Disease Annotations - CTDTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Weight Gain | | ISO | DYNC1LI2 (Homo sapiens) | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:19030233 | |
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# | Reference Title | Reference Citation |
1. | Cytoplasmic dynein. | Allan VJ, Biochem Soc Trans. 2011 Oct;39(5):1169-78. doi: 10.1042/BST0391169. |
2. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
3. | Rat ISS GO annotations from GOA human gene data--August 2006 | GOA data from the GO Consortium |
4. | Molecular analysis of a cytoplasmic dynein light intermediate chain reveals homology to a family of ATPases. | Hughes SM, etal., J Cell Sci 1995 Jan;108 ( Pt 1):17-24. |
5. | Electronic Transfer of LocusLink and RefSeq Data | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
6. | KEGG Annotation Import Pipeline | Pipeline to import KEGG annotations from KEGG into RGD |
7. | GOA pipeline | RGD automated data pipeline |
8. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
9. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
10. | Growth factor regulation of cytoplasmic dynein intermediate chain subunit expression preceding neurite extension. | Salata MW, etal., J Neurosci Res. 2001 Sep 1;65(5):408-16. |
11. | Recruitment of dynein to late endosomes and lysosomes through light intermediate chains. | Tan SC, etal., Mol Biol Cell. 2011 Feb 15;22(4):467-77. doi: 10.1091/mbc.E10-02-0129. Epub 2010 Dec 17. |
12. | Light intermediate chain 1 defines a functional subfraction of cytoplasmic dynein which binds to pericentrin. | Tynan SH, etal., J Biol Chem 2000 Oct 20;275(42):32763-8. |
PMID:12477932 | PMID:19540120 | PMID:19946888 | PMID:21399614 | PMID:21700703 | PMID:26227614 | PMID:30674581 | PMID:31505169 |
Dync1li2 (Rattus norvegicus - Norway rat) |
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DYNC1LI2 (Homo sapiens - human) |
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Dync1li2 (Mus musculus - house mouse) |
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Dync1li2 (Chinchilla lanigera - long-tailed chinchilla) |
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DYNC1LI2 (Pan paniscus - bonobo/pygmy chimpanzee) |
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DYNC1LI2 (Canis lupus familiaris - dog) |
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Dync1li2 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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DYNC1LI2 (Sus scrofa - pig) |
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DYNC1LI2 (Chlorocebus sabaeus - green monkey) |
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Dync1li2 (Heterocephalus glaber - naked mole-rat) |
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Variants in Dync1li2
51 total Variants |
The detailed report is available here: | Full Report | CSV | TAB | Printer | ||||
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
The following QTLs overlap with this region. | Full Report | CSV | TAB | Printer | Gviewer |
alimentary part of gastrointestinal system | circulatory system | endocrine system | exocrine system | hemolymphoid system | hepatobiliary system | integumental system | musculoskeletal system | nervous system | renal system | reproductive system | respiratory system | appendage | |
High | |||||||||||||
Medium | 3 | 43 | 57 | 41 | 19 | 41 | 8 | 11 | 74 | 35 | 41 | 11 | 8 |
Low | |||||||||||||
Below cutoff |
RefSeq Transcripts | NM_001398670 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
NM_031026 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_006255054 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_039098021 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
GenBank Nucleotide | AB008521 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
AB008522 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
AB008523 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
AB008524 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
AC111422 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
BC089794 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
BC108295 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
CH474006 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
JAXUCZ010000019 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
U15138 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
RefSeq Acc Id: | ENSRNOT00000034472 ⟹ ENSRNOP00000029646 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000075978 ⟹ ENSRNOP00000068436 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000076337 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000076353 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000076560 ⟹ ENSRNOP00000067912 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000076604 ⟹ ENSRNOP00000068268 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000076742 ⟹ ENSRNOP00000067920 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000097230 ⟹ ENSRNOP00000082247 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | NM_001398670 ⟹ NP_001385599 | ||||||||||||
RefSeq Status: | VALIDATED | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | NM_031026 ⟹ NP_112288 | ||||||||||||||||||||||||||||
RefSeq Status: | VALIDATED | ||||||||||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_006255054 ⟹ XP_006255116 | ||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_039098021 ⟹ XP_038953949 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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Protein RefSeqs | NP_001385599 | (Get FASTA) | NCBI Sequence Viewer |
NP_112288 | (Get FASTA) | NCBI Sequence Viewer | |
XP_006255116 | (Get FASTA) | NCBI Sequence Viewer | |
XP_038953949 | (Get FASTA) | NCBI Sequence Viewer | |
GenBank Protein | AAA80334 | (Get FASTA) | NCBI Sequence Viewer |
AAH89794 | (Get FASTA) | NCBI Sequence Viewer | |
BAA23368 | (Get FASTA) | NCBI Sequence Viewer | |
BAA23369 | (Get FASTA) | NCBI Sequence Viewer | |
BAA23370 | (Get FASTA) | NCBI Sequence Viewer | |
BAA23371 | (Get FASTA) | NCBI Sequence Viewer | |
EDL87235 | (Get FASTA) | NCBI Sequence Viewer | |
EDL87236 | (Get FASTA) | NCBI Sequence Viewer | |
Ensembl Protein | ENSRNOP00000029646 | ||
ENSRNOP00000029646.2 | |||
ENSRNOP00000067920.1 | |||
ENSRNOP00000068268 | |||
ENSRNOP00000068268.1 | |||
ENSRNOP00000068436.2 | |||
ENSRNOP00000082247.1 | |||
ENSRNOP00060018073 | |||
GenBank Protein | Q62698 | (Get FASTA) | NCBI Sequence Viewer |
RefSeq Acc Id: | NP_112288 ⟸ NM_031026 |
- Peptide Label: | isoform 2 |
- UniProtKB: | Q62698 (UniProtKB/Swiss-Prot), A6JXV7 (UniProtKB/TrEMBL), A0A096MKA1 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | XP_006255116 ⟸ XM_006255054 |
- Peptide Label: | isoform X1 |
- UniProtKB: | A0A096MKA1 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | ENSRNOP00000068436 ⟸ ENSRNOT00000075978 |
RefSeq Acc Id: | ENSRNOP00000029646 ⟸ ENSRNOT00000034472 |
RefSeq Acc Id: | ENSRNOP00000068268 ⟸ ENSRNOT00000076604 |
RefSeq Acc Id: | ENSRNOP00000067920 ⟸ ENSRNOT00000076742 |
RefSeq Acc Id: | ENSRNOP00000067912 ⟸ ENSRNOT00000076560 |
RefSeq Acc Id: | XP_038953949 ⟸ XM_039098021 |
- Peptide Label: | isoform X2 |
RefSeq Acc Id: | ENSRNOP00000082247 ⟸ ENSRNOT00000097230 |
RefSeq Acc Id: | NP_001385599 ⟸ NM_001398670 |
- Peptide Label: | isoform 1 |
- UniProtKB: | Q5D023 (UniProtKB/TrEMBL), A0A096MKA1 (UniProtKB/TrEMBL) |
Name | Modeler | Protein Id | AA Range | Protein Structure |
AF-Q62698-F1-model_v2 | AlphaFold | Q62698 | 1-497 | view protein structure |
eQTL | View at Phenogen | |
WGCNA | View at Phenogen | |
Tissue/Strain Expression | View at Phenogen |
RGD ID: | 13700919 | ||||||||
Promoter ID: | EPDNEW_R11434 | ||||||||
Type: | multiple initiation site | ||||||||
Name: | Dync1li2_1 | ||||||||
Description: | dynein, cytoplasmic 1 light intermediate chain 2 | ||||||||
SO ACC ID: | SO:0000170 | ||||||||
Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||
Experiment Methods: | Single-end sequencing. | ||||||||
Position: |
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Database | Acc Id | Source(s) |
AGR Gene | RGD:621130 | AgrOrtholog |
BioCyc Gene | G2FUF-6643 | BioCyc |
Ensembl Genes | ENSRNOG00000025791 | Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
ENSRNOG00060013394 | UniProtKB/Swiss-Prot | |
Ensembl Transcript | ENSRNOT00000034472 | ENTREZGENE |
ENSRNOT00000034472.5 | UniProtKB/Swiss-Prot | |
ENSRNOT00000075978.3 | UniProtKB/TrEMBL | |
ENSRNOT00000076604 | ENTREZGENE | |
ENSRNOT00000076604.3 | UniProtKB/TrEMBL | |
ENSRNOT00000076742.3 | UniProtKB/TrEMBL | |
ENSRNOT00000097230.1 | UniProtKB/TrEMBL | |
ENSRNOT00060022830 | UniProtKB/Swiss-Prot | |
Gene3D-CATH | 3.40.50.300 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
IMAGE_CLONE | IMAGE:7115029 | IMAGE-MGC_LOAD |
InterPro | Dynein1_light_intermed_chain | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
Dynein_light_int_chain | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
P-loop_NTPase | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
KEGG Report | rno:81655 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
MGC_CLONE | MGC:108664 | IMAGE-MGC_LOAD |
NCBI Gene | 81655 | ENTREZGENE |
PANTHER | CYTOPLASMIC DYNEIN 1 LIGHT INTERMEDIATE CHAIN 2 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
PTHR12688 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Pfam | DLIC | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
PhenoGen | Dync1li2 | PhenoGen |
RatGTEx | ENSRNOG00000025791 | RatGTEx |
ENSRNOG00060013394 | RatGTEx | |
Superfamily-SCOP | SSF52540 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
UniProt | A0A096MIY2_RAT | UniProtKB/TrEMBL |
A0A096MKA1 | ENTREZGENE, UniProtKB/TrEMBL | |
A0A8I6G764_RAT | UniProtKB/TrEMBL | |
A6JXV7 | ENTREZGENE, UniProtKB/TrEMBL | |
DC1L2_RAT | UniProtKB/Swiss-Prot | |
Q5D023 | ENTREZGENE, UniProtKB/TrEMBL | |
Q62698 | ENTREZGENE |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
---|---|---|---|---|---|---|---|
2008-02-19 | Dync1li2 | dynein, cytoplasmic 1 light intermediate chain 2 | Dncli2 | dynein, cytoplasmic, light intermediate polypeptide 2 | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2005-01-20 | Dncli2 | dynein, cytoplasmic, light intermediate polypeptide 2 | LIC-2 dynein light intermediate chain 53/55 | Name updated | 1299863 | APPROVED | |
2002-08-07 | Dncli2 | LIC-2 dynein light intermediate chain 53/55 | Symbol and Name status set to provisional | 70820 | PROVISIONAL |
Note Type | Note | Reference |
---|---|---|
gene_product | region of cDNA shares homology with ABC transporter family of ATPases | 728207 |
gene_protein | cDNA sequence contains 497 codon open reading frame, encodes a 55 kDa polypeptide | 728207 |