Gene: Map2k5 (mitogen activated protein kinase kinase 5) Rattus norvegicus
Symbol: Map2k5
Name: mitogen activated protein kinase kinase 5
Description: ENCODES a protein that exhibits ATP binding; protein kinase activity; INVOLVED IN activation of MAPK activity; cellular response to growth factor stimulus; ERK5 cascade; PARTICIPATES IN Erk5 MAPK signaling pathway; altered Erk5 MAPK signaling pathway; mitogen activated protein kinase signaling pathway; ASSOCIATED WITH amphetamine abuse (ortholog); Amphetamine-Related Disorders (ortholog); Body Weight (ortholog); FOUND IN cytosol; nucleus; spindle (ortholog); INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1,1-dichloroethene; 1,2,4-trimethylbenzene
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: dual specificity mitogen-activated protein kinase kinase 5; MAP kinase kinase 5; MAPK/ERK kinase 5; MAPKK 5; MEK 5; Mek5; mitogen-activated protein kinase kinase 5
Homo sapiens (human) : MAP2K5 (mitogen-activated protein kinase kinase 5)  HGNC
Mus musculus (house mouse) : Map2k5 (mitogen-activated protein kinase kinase 5)  MGI
Chinchilla lanigera (long-tailed chinchilla) : Map2k5 (mitogen-activated protein kinase kinase 5)
Pan paniscus (bonobo/pygmy chimpanzee) : MAP2K5 (mitogen-activated protein kinase kinase 5)
Canis lupus familiaris (dog) : MAP2K5 (mitogen-activated protein kinase kinase 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Map2k5 (mitogen-activated protein kinase kinase 5)
more info ...
Allele / Splice: Map2k5Tn(sb-T2/Bart3)2.150Mcwi  
Genetic Models: F344-Map2k5Tn(sb-T2/Bart3)2.150Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0868,055,976 - 68,282,656 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_5.0867,784,868 - 68,010,809 (-)NCBIRnor5.0rn5Rnor5.0
RGSC_v3.4867,313,472 - 67,542,723 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1867,332,521 - 67,559,107 (-)NCBI
Celera863,038,974 - 63,262,592 (-)NCBI
Cytogenetic Map8q24NCBImapview
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Map2k5
Ensembl Gene
JBrowse: rn5 rn6
NCBI Map Viewer
Vista + UCSC

RGD Object Information
RGD ID: 61890
Created: 2001-04-11
Species: Rattus norvegicus
Last Modified: 2017-06-13
Status: ACTIVE