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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,1-dichloroethene | increases expression | EXP | | 6480464 | vinylidene chloride results in increased expression of MAP2K5 protein | CTD | PMID:14565772 | 1,2,4-trimethylbenzene | decreases expression | EXP | | 6480464 | pseudocumene results in decreased expression of MAP2K5 protein | CTD | PMID:17337753 | 17beta-estradiol | affects expression | ISO | RGD:735708 | 6480464 | Estradiol affects the expression of MAP2K5 mRNA | CTD | PMID:14699072 | 17beta-estradiol | affects expression | ISO | RGD:735708 | 6480464 | Estradiol affects the expression of MAP2K5 mRNA | CTD | PMID:14699072 PMID:22574217 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:62183 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of MAP2K5 mRNA | CTD | PMID:19465110 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:62183 | 6480464 | Tetrachlorodibenzodioxin affects the expression of MAP2K5 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:735708 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of MAP2K5 mRNA | CTD | PMID:21296121 | 3,4-methylenedioxymethamphetamine | increases expression | ISO | RGD:62183 | 6480464 | N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of MAP2K5 mRNA | CTD | PMID:20188158 | 4-hydroxynon-2-enal | decreases expression | ISO | RGD:735708 | 6480464 | 4-hydroxy-2-nonenal results in decreased expression of MAP2K5 mRNA | CTD | PMID:12419474 | acetylsalicylic acid | decreases expression | ISO | RGD:735708 | 6480464 | Aspirin results in decreased expression of MAP2K5 mRNA | CTD | PMID:15928584 | afimoxifene | decreases response to substance | ISO | RGD:735708 | 6480464 | MAP2K5 results in decreased susceptibility to 4-hydroxytamoxifen | CTD | PMID:21233418 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of MAP2K5 mRNA | CTD | PMID:16483693 | arsenite(3-) | increases expression | ISO | RGD:62183 | 6480464 | arsenite results in increased expression of MAP2K5 mRNA | CTD | PMID:18191166 | benzo[a]pyrene | multiple interactions | ISO | RGD:62183 | 6480464 | [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in decreased expression of MAP2K5 mRNA | CTD | PMID:21715664 | benzo[a]pyrene | decreases expression | ISO | RGD:735708 | 6480464 | Benzo(a)pyrene results in decreased expression of MAP2K5 mRNA | CTD | PMID:20064835 more ... | benzo[a]pyrene | increases expression | ISO | RGD:62183 | 6480464 | Benzo(a)pyrene results in increased expression of MAP2K5 mRNA | CTD | PMID:22228805 | benzo[a]pyrene | multiple interactions | ISO | RGD:62183 | 6480464 | AHR protein affects the reaction [Benzo(a)pyrene affects the expression of MAP2K5 mRNA] | CTD | PMID:22228805 | benzo[a]pyrene | decreases expression | ISO | RGD:735708 | 6480464 | Benzo(a)pyrene results in decreased expression of MAP2K5 mRNA | CTD | PMID:20106945 PMID:20064835 | benzo[a]pyrene | decreases expression | ISO | RGD:735708 | 6480464 | Benzo(a)pyrene results in decreased expression of MAP2K5 mRNA | CTD | PMID:20064835 PMID:20106945 | bis(2-chloroethyl) sulfide | affects expression | EXP | | 6480464 | Mustard Gas affects the expression of MAP2K5 mRNA | CTD | PMID:15651846 | bisphenol A | increases methylation | ISO | RGD:735708 | 6480464 | bisphenol A results in increased methylation of MAP2K5 gene | CTD | PMID:22576693 | bisphenol A | decreases expression | ISO | RGD:735708 | 6480464 | bisphenol A results in decreased expression of MAP2K5 mRNA | CTD | PMID:22576693 | choline | multiple interactions | ISO | RGD:62183 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of MAP2K5 mRNA | CTD | PMID:20938992 | cis-caffeic acid | multiple interactions | ISO | RGD:735708 | 6480464 | [Thapsigargin co-treated with caffeic acid] results in decreased expression of MAP2K5 mRNA | CTD | PMID:19442820 | clofibrate | decreases expression | ISO | RGD:62183 | 6480464 | Clofibrate results in decreased expression of MAP2K5 mRNA | CTD | PMID:17585979 | clozapine | decreases expression | EXP | | 6480464 | Clozapine results in decreased expression of MAP2K5 mRNA | CTD | PMID:15860345 | folic acid | multiple interactions | ISO | RGD:62183 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of MAP2K5 mRNA | CTD | PMID:20938992 | haloperidol | decreases expression | EXP | | 6480464 | Haloperidol results in decreased expression of MAP2K5 mRNA | CTD | PMID:15860345 | hydrogen peroxide | decreases expression | ISO | RGD:735708 | 6480464 | Hydrogen Peroxide results in decreased expression of MAP2K5 mRNA | CTD | PMID:12419474 | L-methionine | multiple interactions | ISO | RGD:62183 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of MAP2K5 mRNA | CTD | PMID:20938992 | methamphetamine | affects response to substance | ISO | RGD:735708 | 6480464 | MAP2K5 gene SNP affects the susceptibility to Methamphetamine | CTD | PMID:18316681 | N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of MAP2K5 mRNA | CTD | PMID:18164116 | paracetamol | increases expression | ISO | RGD:62183 | 6480464 | Acetaminophen results in increased expression of MAP2K5 mRNA | CTD | PMID:11752693 | paracetamol | decreases expression | ISO | RGD:735708 | 6480464 | Acetaminophen results in decreased expression of MAP2K5 mRNA | CTD | PMID:22230336 | pirinixic acid | multiple interactions | ISO | RGD:62183 | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of MAP2K5 mRNA | CTD | PMID:19710929 | resveratrol | multiple interactions | ISO | RGD:735708 | 6480464 | MAP2K5 protein promotes the reaction [resveratrol results in increased expression of NOS3 mRNA]; more ... | CTD | PMID:19815564 | sodium dichromate | decreases expression | ISO | RGD:62183 | 6480464 | sodium bichromate results in decreased expression of MAP2K5 mRNA | CTD | PMID:22155349 | tert-butyl hydroperoxide | decreases expression | ISO | RGD:735708 | 6480464 | tert-Butylhydroperoxide results in decreased expression of MAP2K5 mRNA | CTD | PMID:12419474 | tetrachloromethane | affects expression | EXP | | 6480464 | Carbon Tetrachloride affects the expression of MAP2K5 mRNA | CTD | PMID:17805973 | thapsigargin | multiple interactions | ISO | RGD:735708 | 6480464 | [Thapsigargin co-treated with 4-methoxycinnamate methyl ester] results in decreased expression of MAP2K5 mRNA; more ... | CTD | PMID:19442820 | thapsigargin | decreases expression | ISO | RGD:735708 | 6480464 | Thapsigargin results in decreased expression of MAP2K5 mRNA | CTD | PMID:19442820 | trans-resveratrol | multiple interactions | ISO | RGD:735708 | 6480464 | MAP2K5 protein promotes the reaction [resveratrol results in increased expression of NOS3 mRNA]; more ... | CTD | PMID:19815564 | undecane | decreases expression | EXP | | 6480464 | undecane results in decreased expression of MAP2K5 protein | CTD | PMID:17337753 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Gap junction |
| MAPK signaling pathway | |
| Neurotrophin signaling pathway | |
| Pathway Interaction Database | ErbB1 downstream signaling (PID:200133) |
| Trk receptor signaling mediated by the MAPK pathway (PID:200213) | |
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Gap junction |
| MAPK signaling pathway | |
| Neurotrophin signaling pathway | |
| Pathway Interaction Database | ErbB1 downstream signaling (PID:200133) |
| Trk receptor signaling mediated by the MAPK pathway (PID:200213) | |
References - curated| 1. |
English JM, etal., J Biol Chem 1995 Dec 1;270(48):28897-902. |
| 2. |
GOA data from the GO Consortium |
| 3. |
Mehta PB, etal., Oncogene. 2003 Mar 6;22(9):1381-9. |
| 4. |
MGD data from the GO Consortium |
| 5. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 6. |
Nicol RL, etal., EMBO J. 2001 Jun 1;20(11):2757-67. |
| 7. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 8. |
Raviv Z, etal., J Cell Sci. 2004 Apr 1;117(Pt 9):1773-84. Epub 2004 Mar 16. |
| 9. |
RGD automated import pipeline for gene-chemical interactions |
| 10. |
Sato Y, etal., Am J Pathol. 2005 Jan;166(1):49-60. |
| 11. |
Takahashi N, etal., J Mol Cell Cardiol. 2005 Jan;38(1):185-92. Epub 2004 Dec 10. |
| 12. |
Tentative Sequence Data IDs. TIGR Gene Index, Rat Data |
| 13. |
Thomas JA, etal., Am J Physiol Heart Circ Physiol. 2003 Aug;285(2):H597-606. |
| 14. |
Wang X and Tournier C, Cell Signal. 2006 Jun;18(6):753-60. Epub 2006 Jan 6. |
References - uncurated
RGD Disease Portals| Map2k5 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Map2k5 (Rattus norvegicus) |
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| MAP2K5 (Homo sapiens) |
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| Map2k5 (Mus musculus) |
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Position Markers| D8Got101 |
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| D0Mco41 |
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| BF394715 |
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| RH138128 |
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| RH138410 |
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| UniSTS:469815 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_001033987 | (Get FASTA) | Search GEO for Microarray Profiles |
| NM_017246 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | AABR06055254 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06055255 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06055256 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06055257 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01055118 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01055119 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01055120 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01055121 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01055122 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01055123 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01055124 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC078860 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473975 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U37462 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U37463 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U37464 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_001033987 | ||||||||||||||||||||
| RefSeq Status: | VALIDATED | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_001029159 | ||||||||||||||||||||
| Peptide Label: | isoform a | ||||||||||||||||||||
| Position: |
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| RefSeq Acc Id: | NM_017246 | ||||||||||||||||||||
| RefSeq Status: | VALIDATED | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_058942 | ||||||||||||||||||||
| Peptide Label: | isoform b | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_001029159 | (Get FASTA) |
| NP_058942 | (Get FASTA) | |
| GenBank Protein | AAC52320 | (Get FASTA) |
| AAC52321 | (Get FASTA) | |
| AAC52322 | (Get FASTA) | |
| AAH78860 | (Get FASTA) | |
| EDL95767 | (Get FASTA) | |
| EDL95768 | (Get FASTA) | |
| EDL95769 | (Get FASTA) | |
| EDL95770 | (Get FASTA) | |
| EDL95771 | (Get FASTA) | |
| Q62862 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000007926 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000010991 | ENTREZGENE, UniProtKB/Swiss-Prot |
| ENSRNOP00000050528 | ENTREZGENE, UniProtKB/Swiss-Prot | |
| Ensembl Transcript | ENSRNOT00000010991 | ENTREZGENE, UniProtKB/Swiss-Prot |
| ENSRNOT00000051558 | ENTREZGENE, UniProtKB/Swiss-Prot | |
| Entrez Gene | 29568 | ENTREZGENE |
| Germonline | ENSRNOG00000007926 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 115933 | ENTREZGENE |
| IMAGE_CLONE | IMAGE:7122708 | IMAGE-MGC_LOAD |
| InterPro | Kinase-like_dom | UniProtKB/Swiss-Prot |
| OPR_PB1 | UniProtKB/Swiss-Prot | |
| Prot_kinase_cat_dom | UniProtKB/Swiss-Prot | |
| Protein_kinase_ATP_BS | UniProtKB/Swiss-Prot | |
| Ser/Thr_prot_kinase_AS | UniProtKB/Swiss-Prot | |
| Ser/Thr_prot_kinase_dom | UniProtKB/Swiss-Prot | |
| IPI | IPI00209255 | UniProtKB/Swiss-Prot |
| IPI00230846 | UniProtKB/Swiss-Prot | |
| IPI00230847 | UniProtKB/Swiss-Prot | |
| KEGG Report | rno:29568 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGC_CLONE | MGC:93521 | IMAGE-MGC_LOAD |
| Pfam | PB1 | UniProtKB/Swiss-Prot |
| Pkinase | UniProtKB/Swiss-Prot | |
| PROSITE | PROTEIN_KINASE_ATP | UniProtKB/Swiss-Prot |
| PROTEIN_KINASE_DOM | UniProtKB/Swiss-Prot | |
| PROTEIN_KINASE_ST | UniProtKB/Swiss-Prot | |
| SMART | PB1 | UniProtKB/Swiss-Prot |
| S_TKc | UniProtKB/Swiss-Prot | |
| Superfamily-SCOP | Kinase_like | UniProtKB/Swiss-Prot |
| TIGR | TC216643 | |
| UniGene | Rn.11054 | ENTREZGENE |
| UniProt | MP2K5_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2002-06-10 | Map2k5 | mitogen activated protein kinase kinase 5 | Name updated | 1488 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_function | does not phosphorylate ERK1, ERK2, ERK3, JNK/SAPK, or p38/HOG1 | 61658 |
| More on Map2k5 | |
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Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 61890 |
| Created: | 2001-04-11 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




