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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:3766
Term: clozapine
Definition: A benzodiazepine that is 5H-dibenzo[b,e][1,4]diazepine substituted by a chloro group at position 8 and a 4-methylpiperazin-1-yl group at position 11. It is a second generation antipsychotic used in the treatment of psychiatric disorders like schizophrenia.
Chemical ID: MESH:D003024
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1decreases expressionEXP 6480464CTDClozapine results in decreased expression of MAPK1 mRNAPMID:15860345
Mapk1decreases phosphorylationISOMapk1 (Mus musculus)6480464CTDClozapine results in decreased phosphorylation of MAPK1 proteinPMID:12871586
Mapk1multiple interactionsISOMapk1 (Mus musculus)6480464CTDClozapine inhibits the reaction [Haloperidol results in increased phosphorylation of MAPK1 protein]PMID:12871586
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