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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2848
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Htr2c
Name: 5-hydroxytryptamine receptor 2C
Acc ID: CHEBI:3766
Term: clozapine
Definition: A benzodiazepine that is 5H-dibenzo[b,e][1,4]diazepine substituted by a chloro group at position 8 and a 4-methylpiperazin-1-yl group at position 11. It is a second generation antipsychotic used in the treatment of psychiatric disorders like schizophrenia.
Chemical ID: MESH:D003024
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Htr2caffects bindingEXP 6480464CTDClozapine binds to HTR2C proteinPMID:9723970
Htr2cdecreases expressionEXP 6480464CTDClozapine results in decreased expression of HTR2C mRNAPMID:17868938
Htr2caffects bindingISOHTR2C (Homo sapiens)6480464CTDClozapine binds to HTR2C proteinPMID:16983399
Htr2caffects response to substanceISOHTR2C (Homo sapiens)6480464CTDHTR2C gene polymorphism affects the susceptibility to Clozapine; HTR2C gene SNP affects the susceptibility to Clozapine; HTR2C promoter SNP affects the susceptibility to Clozapine; HTR2C protein affects the susceptibility to ClozapinePMID:12668355 PMID:15635667 PMID:19142101 PMID:19142110
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