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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2522
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Drd4
Name: dopamine receptor D4
Acc ID: CHEBI:3766
Term: clozapine
Definition: A benzodiazepine that is 5H-dibenzo[b,e][1,4]diazepine substituted by a chloro group at position 8 and a 4-methylpiperazin-1-yl group at position 11. It is a second generation antipsychotic used in the treatment of psychiatric disorders like schizophrenia.
Chemical ID: MESH:D003024
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Drd4affects bindingEXP 7248459RGDClozapine binds to Drd4 protein 
Drd4affects bindingEXP 6480464CTDClozapine analog binds to DRD4 proteinPMID:11997696
Drd4affects bindingISODRD4 (Homo sapiens)6480464CTDClozapine binds to DRD4 proteinPMID:11997696 PMID:31323226
Drd4affects response to substanceISODRD4 (Homo sapiens)6480464CTDDRD4 gene polymorphism affects the susceptibility to ClozapinePMID:16223700
Drd4multiple interactionsISODRD4 (Homo sapiens)6480464CTDClozapine inhibits the reaction [Dopamine results in increased activity of DRD4 protein]PMID:31323226
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