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Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 3',5'-cyclic AMP | multiple interactions | ISO | RGD:10487 | 6480464 | [3-((4-(4-chlorophenyl)piperazin-1-yl)methyl)-1H-pyrrolo(2,3-b)pyridine binds to and results in decreased activity of DRD4 protein] inhibits the reaction [Naloxone results in increased abundance of Cyclic AMP] | CTD | PMID:15542745 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of DRD4 mRNA | CTD | PMID:16483693 | benzo[a]pyrene | multiple interactions | ISO | RGD:10487 | 6480464 | [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in decreased expression of DRD4 mRNA; more ... | CTD | PMID:21715664 | bis(2-ethylhexyl) phthalate | decreases expression | EXP | | 6480464 | Diethylhexyl Phthalate results in decreased expression of DRD4 mRNA | CTD | PMID:15518916 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of DRD4 mRNA | CTD | PMID:15079872 | cadmium atom | multiple interactions | EXP | | 6480464 | Cadmium inhibits the reaction [3-N-methylspiperone binds to DRD4 protein] | CTD | PMID:10215675 | chlorpyrifos | affects expression | EXP | | 6480464 | Chlorpyrifos affects the expression of DRD4 mRNA | CTD | PMID:17452286 PMID:18812211 | chlorpyrifos | affects expression | EXP | | 6480464 | Chlorpyrifos affects the expression of DRD4 mRNA | CTD | PMID:18812211 PMID:17452286 | choline | multiple interactions | ISO | RGD:10487 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of DRD4 gene | CTD | PMID:20938992 | clozapine | affects binding | ISO | RGD:736138 | 6480464 | Clozapine binds to DRD4 protein | CTD | PMID:11997696 | clozapine | affects binding | EXP | | 6480464 | Clozapine analog binds to DRD4 protein | CTD | PMID:11997696 | clozapine | affects response to substance | ISO | RGD:736138 | 6480464 | DRD4 gene polymorphism affects the susceptibility to Clozapine | CTD | PMID:16223700 | cocaine | increases response to substance | ISO | RGD:736138 | 6480464 | DRD4 polymorphism results in increased susceptibility to Cocaine | CTD | PMID:17671965 | cocaine | affects expression | EXP | | 6480464 | Cocaine affects the expression of DRD4 mRNA | CTD | PMID:20187946 | copper atom | multiple interactions | EXP | | 6480464 | Copper inhibits the reaction [3-N-methylspiperone binds to DRD4 protein] | CTD | PMID:10215675 | copper(0) | multiple interactions | EXP | | 6480464 | Copper inhibits the reaction [3-N-methylspiperone binds to DRD4 protein] | CTD | PMID:10215675 | diazinon | affects expression | EXP | | 6480464 | Diazinon affects the expression of DRD4 mRNA | CTD | PMID:17452286 | dieldrin | decreases expression | EXP | | 6480464 | Dieldrin results in decreased expression of DRD4 mRNA | CTD | PMID:18812211 | dopamine | multiple interactions | EXP | | 6480464 | DRD4 protein affects the reaction [Dopamine binds to DRD2 protein] | CTD | PMID:15716360 | folic acid | multiple interactions | ISO | RGD:10487 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of DRD4 gene | CTD | PMID:20938992 | gold atom | multiple interactions | EXP | | 6480464 | Gold inhibits the reaction [3-N-methylspiperone binds to DRD4 protein] | CTD | PMID:10215675 | gold(0) | multiple interactions | EXP | | 6480464 | Gold inhibits the reaction [3-N-methylspiperone binds to DRD4 protein] | CTD | PMID:10215675 | hydralazine | multiple interactions | ISO | RGD:736138 | 6480464 | [Hydralazine co-treated with Valproic Acid] results in increased expression of DRD4 mRNA | CTD | PMID:17183730 | L-methionine | multiple interactions | ISO | RGD:10487 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of DRD4 gene | CTD | PMID:20938992 | maneb | multiple interactions | ISO | RGD:10487 | 6480464 | [Paraquat co-treated with Maneb] results in increased expression of DRD4 protein | CTD | PMID:22563483 | mercury atom | multiple interactions | EXP | | 6480464 | Mercury inhibits the reaction [3-N-methylspiperone binds to DRD4 protein] | CTD | PMID:10215675 | mercury(0) | multiple interactions | EXP | | 6480464 | Mercury inhibits the reaction [3-N-methylspiperone binds to DRD4 protein] | CTD | PMID:10215675 | methamphetamine | affects response to substance | ISO | RGD:736138 | 6480464 | DRD4 gene polymorphism affects the susceptibility to Methamphetamine | CTD | PMID:19462300 | methamphetamine | multiple interactions | ISO | RGD:10487 | 6480464 | [NRA 0160 binds to and results in decreased activity of DRD4 protein] which results in decreased susceptibility to Methamphetamine | CTD | PMID:10579464 | methamphetamine | increases response to substance | ISO | RGD:736138 | 6480464 | DRD4 gene polymorphism results in increased susceptibility to Methamphetamine | CTD | PMID:15274053 | methylphenidate | affects response to substance | ISO | RGD:736138 | 6480464 | DRD4 promoter mutant form affects the susceptibility to Methylphenidate | CTD | PMID:17023870 | morphine | increases expression | EXP | | 6480464 | Morphine results in increased expression of DRD4 mRNA | CTD | PMID:15183518 | naloxone | multiple interactions | ISO | RGD:10487 | 6480464 | [3-((4-(4-chlorophenyl)piperazin-1-yl)methyl)-1H-pyrrolo(2,3-b)pyridine binds to and results in decreased activity of DRD4 protein] inhibits the reaction [Naloxone results in increased abundance of Cyclic AMP] | CTD | PMID:15542745 | paraquat | affects expression | EXP | | 6480464 | Paraquat affects the expression of DRD4 mRNA | CTD | PMID:15206577 | paraquat | multiple interactions | ISO | RGD:10487 | 6480464 | [Paraquat co-treated with Maneb] results in increased expression of DRD4 protein | CTD | PMID:22563483 | pyridaben | decreases expression | ISO | RGD:10487 | 6480464 | pyridaben results in decreased expression of DRD4 mRNA | CTD | PMID:22563483 | ropinirole | multiple interactions | ISO | RGD:736138 | 6480464 | ropinirole binds to and results in increased activity of DRD4 protein | CTD | PMID:18393062 | silver atom | multiple interactions | EXP | | 6480464 | Silver inhibits the reaction [3-N-methylspiperone binds to DRD4 protein] | CTD | PMID:10215675 | silver(0) | multiple interactions | EXP | | 6480464 | Silver inhibits the reaction [3-N-methylspiperone binds to DRD4 protein] | CTD | PMID:10215675 | valproic acid | multiple interactions | ISO | RGD:736138 | 6480464 | [Hydralazine co-treated with Valproic Acid] results in increased expression of DRD4 mRNA | CTD | PMID:17183730 | zinc atom | multiple interactions | EXP | | 6480464 | Zinc inhibits the reaction [3-N-methylspiperone binds to DRD4 protein] | CTD | PMID:10215675 | zinc(0) | multiple interactions | EXP | | 6480464 | Zinc inhibits the reaction [3-N-methylspiperone binds to DRD4 protein] | CTD | PMID:10215675 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Dopaminergic synapse |
| Neuroactive ligand-receptor interaction | |
Disease AnnotationsGene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Dopaminergic synapse |
| Neuroactive ligand-receptor interaction | |
References - curated| 1. |
Azdad K, etal., J Neurophysiol 2003 Aug;90(2):559-65. Epub 2003 Apr 23. |
| 2. |
Becker KG, etal., Nat Genet 2004 May;36(5):431-2. |
| 3. |
Floran B, etal., Eur J Pharmacol. 2004 Sep 13;498(1-3):97-102. |
| 4. |
Floresco SB and Tse MT, J Neurosci. 2007 Feb 21;27(8):2045-57. |
| 5. |
GOA data from the GO Consortium |
| 6. |
Griffon N, etal., Brain Res Mol Brain Res 2003 Sep 10;117(1):47-57. |
| 7. |
Gu Z, etal., Mol Pharmacol. 2006 Mar;69(3):813-22. Epub 2005 Dec 19. |
| 8. |
Klitten LL, etal., Exp Eye Res. 2008 Nov;87(5):471-7. Epub 2008 Aug 20. |
| 9. |
Kortagere S, etal., Mol Pharmacol. 2004 Dec;66(6):1491-9. Epub 2004 Sep 24. |
| 10. |
Kumar U and Patel SC, Brain Res. 2007 Feb 2;1131(1):187-96. Epub 2006 Dec 19. |
| 11. |
Kustanovich V, etal., Mol Psychiatry 2004 Jul;9(7):711-7. |
| 12. |
Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7 |
| 13. |
LaHoste GJ, etal., Mol Psychiatry 1996 May;1(2):121-4. |
| 14. |
Laviolette SR, etal., J Neurosci. 2005 Jun 29;25(26):6066-75. |
| 15. |
Li Q, etal., Neurochem Int. 2007 May;50(6):848-57. Epub 2007 Mar 1. |
| 16. |
Melis MR, etal., Neurosci Lett. 2005 Apr 29;379(1):59-62. Epub 2005 Jan 12. |
| 17. |
MGD data from the GO Consortium |
| 18. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 19. |
Nothen MM, etal., Hum Mol Genet. 1994 Dec;3(12):2207-12. |
| 20. |
O'Malley KL, etal., New Biol 1992 Feb;4(2):137-46. |
| 21. |
Pfeiffer UJ and Fendt M, Neuroreport. 2006 May 29;17(8):847-50. |
| 22. |
RGD automated data pipeline |
| 23. |
RGD automated import pipeline for gene-chemical interactions |
| 24. |
RGD Automated Pipelines |
| 25. |
Rivera A, etal., J Neurochem 2002 Jan;80(2):219-29. |
| 26. |
Romo-Parra H, etal., Hippocampus. 2005;15(2):254-9. |
| 27. |
Svingos AL, etal., Synapse. 2000 Jun 1;36(3):222-32. |
| 28. |
Taurines R, etal., World J Biol Psychiatry. 2011 Sep;12 Suppl 1:104-8. |
| 29. |
Tentative Sequence Data IDs. TIGR Gene Index, Rat Data |
| 30. |
Wedzony K, etal., J Physiol Pharmacol. 2000 Jun;51(2):205-21. |
| 31. |
Zhang K, etal., Neuropsychopharmacology 2002 May;26(5):625-33. |
| 32. |
Zhang K, etal., Neuropsychopharmacology. 2004 Sep;29(9):1648-55. |
References - uncurated| PubMed | 12544452 |
| 14519509 | |
| 15197646 | |
| 16198123 | |
| 17593530 | |
| 18620029 | |
| 18662324 | |
| 19103603 | |
| 19179335 | |
| 19482058 | |
| 19598175 | |
| 20884758 | |
| 21135234 | |
| 21599953 | |
| 21622557 | |
| 22815864 | |
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RGD Disease Portals| Drd4 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Drd4 (Rattus norvegicus) |
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| DRD4 (Homo sapiens) |
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| Drd4 (Mus musculus) |
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Position Markers| D1Wox57 |
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| RH94697 |
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| RH142302 |
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| BI284462 |
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| Drd4 |
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| UniSTS:142868 |
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| Drd4 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_012944 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06009341 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01009038 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AC118351 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473953 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M84009 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U03551 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_012944 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_037076 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_037076 | (Get FASTA) |
| GenBank Protein | AAA18588 | (Get FASTA) |
| AAA96716 | (Get FASTA) | |
| EDM12018 | (Get FASTA) | |
| EDM12019 | (Get FASTA) | |
| P30729 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000017927 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000024137 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000024137 | ENTREZGENE, UniProtKB/TrEMBL |
| Entrez Gene | 25432 | ENTREZGENE |
| Germonline | ENSRNOG00000017927 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 20215 | ENTREZGENE |
| InterPro | 7TM_GPCR_Rhodpsn | UniProtKB/Swiss-Prot |
| Dopa_D4_rcpt | UniProtKB/Swiss-Prot | |
| Dopamine_rcpt | UniProtKB/Swiss-Prot | |
| GPCR_Rhodpsn_supfam | UniProtKB/Swiss-Prot | |
| IPI | IPI00211801 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:25432 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Pfam | 7tm_1 | UniProtKB/Swiss-Prot |
| PharmGKB | DRD4 | RGD |
| PRINTS | DOPAMINED4R | UniProtKB/Swiss-Prot |
| DOPAMINER | UniProtKB/Swiss-Prot | |
| GPCRRHODOPSN | UniProtKB/Swiss-Prot | |
| PROSITE | G_PROTEIN_RECEP_F1_1 | UniProtKB/Swiss-Prot |
| G_PROTEIN_RECEP_F1_2 | UniProtKB/Swiss-Prot | |
| TIGR | TC226919 | |
| UniGene | Rn.10159 | ENTREZGENE |
| UniProt | DRD4_RAT | UniProtKB/Swiss-Prot |
| F1LLX2_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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| 2006-03-30 | Drd4 | dopamine receptor D4 | dopamine receptor 4 | Name updated | 10779 | APPROVED | |
| 2002-06-10 | Drd4 | Dopamine receptor D4 | Symbol and Name status set to approved | 1490 | APPROVED |
| More on Drd4 | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 2522 |
| Created: | 2000-05-25 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.