Ilkap (ILK associated serine/threonine phosphatase) - Rat Genome Database

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Pathways
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Gene: Ilkap (ILK associated serine/threonine phosphatase) Rattus norvegicus
Analyze
Symbol: Ilkap
Name: ILK associated serine/threonine phosphatase
RGD ID: 620128
Description: Enables protein serine/threonine phosphatase activity. Involved in regulation of nuclear cell cycle DNA replication. Predicted to be located in cytoplasm. Orthologous to human ILKAP (ILK associated serine/threonine phosphatase); PARTICIPATES IN integrin mediated signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: AF095927; integrin-linked kinase-associated serine/threonine phosphatase; integrin-linked kinase-associated serine/threonine phosphatase 2C; PP2Cdelta; protein phosphatase 2C
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8999,413,981 - 99,436,262 (-)NCBIGRCr8
mRatBN7.2991,966,440 - 91,988,791 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl991,966,441 - 91,988,892 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9100,393,225 - 100,415,489 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09105,528,983 - 105,551,247 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09103,892,577 - 103,914,843 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0998,514,599 - 98,536,586 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl998,514,584 - 98,536,581 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0998,190,668 - 98,212,634 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4990,602,949 - 90,626,753 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1990,807,717 - 90,831,522 (-)NCBI
Celera989,507,483 - 89,529,779 (-)NCBICelera
Cytogenetic Map9q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA)
nucleus  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Protein phosphatase 2C binds selectively to and dephosphorylates metabotropic glutamate receptor 3. Flajolet M, etal., Proc Natl Acad Sci U S A 2003 Dec 23;100(26):16006-11. Epub 2003 Dec 08.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. ILK, PINCH and parvin: the tIPP of integrin signalling. Legate KR, etal., Nat Rev Mol Cell Biol. 2006 Jan;7(1):20-31.
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
8. Cloning and characterization of a novel mammalian PP2C isozyme. Tong Y, etal., J Biol Chem 1998 Dec 25;273(52):35282-90.
Additional References at PubMed
PMID:15489334  


Genomics

Comparative Map Data
Ilkap
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8999,413,981 - 99,436,262 (-)NCBIGRCr8
mRatBN7.2991,966,440 - 91,988,791 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl991,966,441 - 91,988,892 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9100,393,225 - 100,415,489 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09105,528,983 - 105,551,247 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09103,892,577 - 103,914,843 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0998,514,599 - 98,536,586 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl998,514,584 - 98,536,581 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0998,190,668 - 98,212,634 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4990,602,949 - 90,626,753 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1990,807,717 - 90,831,522 (-)NCBI
Celera989,507,483 - 89,529,779 (-)NCBICelera
Cytogenetic Map9q36NCBI
ILKAP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382238,170,402 - 238,203,695 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2238,170,402 - 238,203,708 (-)EnsemblGRCh38hg38GRCh38
GRCh372239,079,043 - 239,112,336 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362238,743,782 - 238,777,063 (-)NCBINCBI36Build 36hg18NCBI36
Build 342238,861,043 - 238,894,324NCBI
Celera2232,791,584 - 232,824,882 (-)NCBICelera
Cytogenetic Map2q37.3NCBI
HuRef2230,870,240 - 230,903,537 (-)NCBIHuRef
CHM1_12239,084,148 - 239,118,134 (-)NCBICHM1_1
T2T-CHM13v2.02238,660,143 - 238,693,437 (-)NCBIT2T-CHM13v2.0
Ilkap
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39191,301,568 - 91,326,566 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl191,301,583 - 91,326,537 (-)EnsemblGRCm39 Ensembl
GRCm38191,373,846 - 91,398,844 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl191,373,861 - 91,398,815 (-)EnsemblGRCm38mm10GRCm38
MGSCv37193,272,408 - 93,295,360 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36193,206,237 - 93,229,189 (-)NCBIMGSCv36mm8
Celera194,312,974 - 94,349,943 (-)NCBICelera
Cytogenetic Map1DNCBI
cM Map146.11NCBI
Ilkap
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555422,391,431 - 2,408,732 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555422,391,432 - 2,407,559 (+)NCBIChiLan1.0ChiLan1.0
ILKAP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213140,802,982 - 140,836,441 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B140,817,949 - 140,851,383 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B125,403,220 - 125,436,614 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B244,253,970 - 244,278,317 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B244,253,970 - 244,278,317 (-)Ensemblpanpan1.1panPan2
ILKAP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12548,666,850 - 48,689,405 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2548,666,849 - 48,689,381 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2549,162,771 - 49,185,336 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02549,052,924 - 49,075,502 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2549,052,925 - 49,075,569 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12548,928,074 - 48,950,661 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02548,716,721 - 48,739,506 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02548,948,767 - 48,971,334 (-)NCBIUU_Cfam_GSD_1.0
Ilkap
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303190,617,020 - 190,641,591 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936525303,499 - 322,563 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936525303,436 - 322,677 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ILKAP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15137,740,292 - 137,765,784 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115137,740,291 - 137,765,758 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215152,222,010 - 152,247,435 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ILKAP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110124,191,926 - 124,225,735 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10124,190,785 - 124,225,678 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604075,190,863 - 75,224,901 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ilkap
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248473,320,788 - 3,344,705 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248473,321,400 - 3,344,725 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ilkap
45 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:126
Count of miRNA genes:103
Interacting mature miRNAs:112
Transcripts:ENSRNOT00000027295
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)975712843111552878Rat
4889852Pur26Proteinuria QTL 26150.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)977813894101597663Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)977813894111552878Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)979271511102910209Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)98636963192058970Rat

Markers in Region
BF387256  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2991,966,738 - 91,966,892 (+)MAPPERmRatBN7.2
Rnor_6.0998,514,898 - 98,515,051NCBIRnor6.0
Rnor_5.0998,190,946 - 98,191,099UniSTSRnor5.0
RGSC_v3.4990,603,227 - 90,603,380UniSTSRGSC3.4
Celera989,507,761 - 89,507,914UniSTS
RH 3.4 Map9796.4UniSTS
Cytogenetic Map9q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 40 11 8
Low 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000027295   ⟹   ENSRNOP00000027295
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl991,966,452 - 91,988,753 (-)Ensembl
Rnor_6.0 Ensembl998,514,584 - 98,536,581 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000096782   ⟹   ENSRNOP00000077906
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl991,966,953 - 91,988,753 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000115342   ⟹   ENSRNOP00000083927
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl991,966,441 - 91,982,769 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000119384   ⟹   ENSRNOP00000083940
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl991,966,441 - 91,988,892 (-)Ensembl
RefSeq Acc Id: NM_022606   ⟹   NP_072128
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8999,413,998 - 99,436,262 (-)NCBI
mRatBN7.2991,966,461 - 91,988,725 (-)NCBI
Rnor_6.0998,514,620 - 98,536,586 (-)NCBI
Rnor_5.0998,190,668 - 98,212,634 (-)NCBI
RGSC_v3.4990,602,949 - 90,626,753 (-)RGD
Celera989,507,483 - 89,529,779 (-)RGD
Sequence:
RefSeq Acc Id: XM_039084169   ⟹   XP_038940097
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8999,413,981 - 99,428,278 (-)NCBI
mRatBN7.2991,966,440 - 91,988,697 (-)NCBI
RefSeq Acc Id: XM_039084170   ⟹   XP_038940098
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8999,413,981 - 99,428,278 (-)NCBI
mRatBN7.2991,966,440 - 91,988,791 (-)NCBI
RefSeq Acc Id: XM_063267686   ⟹   XP_063123756
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8999,413,981 - 99,428,262 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_072128   ⟸   NM_022606
- UniProtKB: Q9Z1Z6 (UniProtKB/Swiss-Prot),   Q6P6U8 (UniProtKB/Swiss-Prot),   A0A0G2JSS1 (UniProtKB/TrEMBL),   A6JQR2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000027295   ⟸   ENSRNOT00000027295
RefSeq Acc Id: XP_038940098   ⟸   XM_039084170
- Peptide Label: isoform X2
- UniProtKB: A6JQR3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038940097   ⟸   XM_039084169
- Peptide Label: isoform X2
- UniProtKB: A6JQR3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000077906   ⟸   ENSRNOT00000096782
RefSeq Acc Id: ENSRNOP00000083940   ⟸   ENSRNOT00000119384
RefSeq Acc Id: ENSRNOP00000083927   ⟸   ENSRNOT00000115342
RefSeq Acc Id: XP_063123756   ⟸   XM_063267686
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GBB0 (UniProtKB/TrEMBL)
Protein Domains
PPM-type phosphatase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z1Z6-F1-model_v2 AlphaFold Q9Z1Z6 1-392 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696859
Promoter ID:EPDNEW_R7384
Type:initiation region
Name:Ilkap_1
Description:ILK associated serine/threonine phosphatase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0998,536,637 - 98,536,697EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620128 AgrOrtholog
BioCyc Gene G2FUF-26717 BioCyc
Ensembl Genes ENSRNOG00000020115 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000027295 ENTREZGENE
  ENSRNOT00000027295.6 UniProtKB/TrEMBL
  ENSRNOT00000096782.1 UniProtKB/TrEMBL
  ENSRNOT00000115342.1 UniProtKB/TrEMBL
  ENSRNOT00000119384.1 UniProtKB/TrEMBL
Gene3D-CATH 3.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5621497 IMAGE-MGC_LOAD
InterPro PP2C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PP2C_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PPM-type_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PPM-type_phosphatase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64538 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72440 IMAGE-MGC_LOAD
NCBI Gene 64538 ENTREZGENE
PANTHER INTEGRIN-LINKED KINASE-ASSOCIATED SERINE/THREONINE PHOSPHATASE 2C UniProtKB/TrEMBL
  PROTEIN PHOSPHATASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN PHOSPHATASE 1B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN PHOSPHATASE 2C UniProtKB/TrEMBL
Pfam PP2C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ilkap PhenoGen
PROSITE PPM_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PPM_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020115 RatGTEx
SMART PP2Cc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF81606 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JSS1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5YCJ9_RAT UniProtKB/TrEMBL
  A0A8I6GBA3_RAT UniProtKB/TrEMBL
  A0A8I6GBB0 ENTREZGENE, UniProtKB/TrEMBL
  A6JQR0_RAT UniProtKB/TrEMBL
  A6JQR1_RAT UniProtKB/TrEMBL
  A6JQR2 ENTREZGENE, UniProtKB/TrEMBL
  A6JQR3 ENTREZGENE, UniProtKB/TrEMBL
  A6JQR4_RAT UniProtKB/TrEMBL
  A6JQR5_RAT UniProtKB/TrEMBL
  A6JQR7_RAT UniProtKB/TrEMBL
  A6JQR8_RAT UniProtKB/TrEMBL
  A6JQR9_RAT UniProtKB/TrEMBL
  A6JQS0_RAT UniProtKB/TrEMBL
  ILKAP_RAT UniProtKB/Swiss-Prot
  Q6P6U8 ENTREZGENE
  Q9Z1Z6 ENTREZGENE
UniProt Secondary Q6P6U8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-02-01 Ilkap  ILK associated serine/threonine phosphatase  Ilkap  integrin-linked kinase-associated serine/threonine phosphatase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-02 Ilkap  integrin-linked kinase-associated serine/threonine phosphatase  Ilkap  integrin-linked kinase-associated serine/threonine phosphatase 2C  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Ilkap  integrin-linked kinase-associated serine/threonine phosphatase 2C  AF095927  protein phosphatase 2C  Symbol and Name updated 1299863 APPROVED
2002-08-07 AF095927  protein phosphatase 2C      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression widely expressed in all tissues 632254
gene_function recombinant protein purified from bacteria exhibited a potent Mn2+-dependent serine/threonine phosphatase activity 632254
gene_mutations_overexpression overexpression causes cell cycle arrest at early S phase and inhibition of DNA synthesis and leading to cell death 632254
gene_protein 392 amino acids 632254
gene_regulation expression induced by the addition of ethanol to the culture medium or UV irradiation of cells 632254