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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:epidermal growth factor/neuregulin signaling pathway
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Accession:PW:0000170 term browser browse the term
Definition:Members of the EGF/neuregulin superfamily are important regulators of tissue development and repair. A characteristic feature is the presence of the EGF module, a 36-40 amino acid sequence with a disulfide-bonded three-loop structure necessary for receptor binding.
Synonyms:related_synonym: EGF/neuregulin signaling pathway;   Signaling by EGFR;   epidermal growth factor receptor signaling pathway
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show annotations for term's descendants           Sort by:
epidermal growth factor/neuregulin signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase IEA KEGG rno:04012 NCBI chr 3:35,377,587...35,480,843
Ensembl chr 3:35,377,391...35,480,846 		JBrowse link
G Abl2 ABL proto-oncogene 2, non-receptor tyrosine kinase IEA KEGG rno:04012 NCBI chr13:71,223,902...71,319,770
Ensembl chr13:71,224,019...71,389,775 		JBrowse link
G Adam10 ADAM metallopeptidase domain 10 ISO RGD PMID:15688065 RGD:2317976 NCBI chr 8:80,226,862...80,358,728
Ensembl chr 8:80,226,674...80,361,600 		JBrowse link
G Adam12 ADAM metallopeptidase domain 12 ISO RGD PMID:15688065 RGD:2317976 NCBI chr 1:198,116,968...198,443,680
Ensembl chr 1:198,116,975...198,447,552 		JBrowse link
G Adam17 ADAM metallopeptidase domain 17 ISO RGD PMID:15688065 RGD:2317976 NCBI chr 6:46,601,583...46,663,690
Ensembl chr 6:46,601,583...46,649,344 		JBrowse link
G Adam19 ADAM metallopeptidase domain 19 ISO RGD PMID:15688065 RGD:2317976 NCBI chr10:30,992,713...31,084,455
Ensembl chr10:30,992,754...31,084,455 		JBrowse link
G Adam9 ADAM metallopeptidase domain 9 ISO RGD PMID:15688065 RGD:2317976 NCBI chr16:73,725,186...73,804,284
Ensembl chr16:73,725,114...73,804,646 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 IEA KEGG rno:04012 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 IEA KEGG rno:04012 NCBI chr 1:92,004,705...92,061,420
Ensembl chr 1:92,014,859...92,061,420 		JBrowse link
G Akt3 AKT serine/threonine kinase 3 IEA KEGG rno:04012 NCBI chr13:91,475,839...91,758,060
Ensembl chr13:91,475,839...91,748,020 		JBrowse link
G Areg amphiregulin IDA
ISO
IEA 		PID
KEGG
RGD		 PMID:15509566 PMID:15982853 PID:200159 rno:04012, RGD:1578718, RGD:2317963 NCBI chr14:17,256,384...17,265,641
Ensembl chr14:17,256,384...17,265,641 		JBrowse link
G Bad BCL2-associated agonist of cell death IEA KEGG rno:04012 NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034 		JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase IEA KEGG rno:04012 NCBI chr 4:69,329,772...69,476,931
Ensembl chr 4:69,342,813...69,476,931 		JBrowse link
G Btc betacellulin ISO
IEA
IDA 		KEGG
PID
RGD		 PMID:15982853 PMID:11564606 PID:200159 rno:04012, RGD:2317963, RGD:2324625 NCBI chr14:16,992,668...17,031,178
Ensembl chr14:16,992,193...17,033,078 		JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha IEA KEGG rno:04012 NCBI chr18:56,648,779...56,711,505
Ensembl chr18:56,649,025...56,711,504 		JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II beta IEA KEGG rno:04012 NCBI chr14:85,059,166...85,148,121
Ensembl chr14:85,059,191...85,148,485 		JBrowse link
G Camk2d calcium/calmodulin-dependent protein kinase II delta IEA KEGG rno:04012 NCBI chr 2:217,698,324...217,961,898
Ensembl chr 2:217,698,551...217,960,276 		JBrowse link
G Camk2g calcium/calmodulin-dependent protein kinase II gamma IEA KEGG rno:04012 NCBI chr15:3,553,238...3,612,310
Ensembl chr15:3,553,294...3,612,310 		JBrowse link
G Cbl Cbl proto-oncogene ISO
IEA 		KEGG
RGD		 PMID:16829981 rno:04012, RGD:2317988 NCBI chr 8:53,384,656...53,468,067
Ensembl chr 8:53,384,656...53,468,067 		JBrowse link
G Cblb Cbl proto-oncogene B IEA KEGG rno:04012 NCBI chr11:62,058,829...62,225,904
Ensembl chr11:62,061,653...62,225,778 		JBrowse link
G Cblc Cbl proto-oncogene C IEA KEGG rno:04012 NCBI chr 1:88,567,930...88,584,709
Ensembl chr 1:88,567,932...88,584,709 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A IEA KEGG rno:04012 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B IEA KEGG rno:04012 NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498 		JBrowse link
G Crk CRK proto-oncogene, adaptor protein IEA KEGG rno:04012 NCBI chr10:61,028,736...61,054,971
Ensembl chr10:61,028,757...61,082,988 		JBrowse link
G Crkl CRK like proto-oncogene, adaptor protein IEA KEGG rno:04012 NCBI chr11:97,033,033...97,067,457
Ensembl chr11:97,024,782...97,067,457 		JBrowse link
G Egf epidermal growth factor IDA
IEA
ISO 		KEGG
PID
RGD		 PMID:2260661 PMID:15982853 PID:200101 PID:200159 rno:04012, RGD:1626483, RGD:2317963 NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:220,893,660...220,976,297 		JBrowse link
G Egfr epidermal growth factor receptor IMP
IEA
ISO 		KEGG
PID
RGD		 PMID:16648628 PMID:15486316 PMID:15982853 PID:200101 PID:200159 rno:04012, RGD:1581898, RGD:1581908, RGD:2317963 NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 IEA KEGG rno:04012 NCBI chr16:71,495,457...71,508,845
Ensembl chr16:71,487,930...71,508,874 		JBrowse link
G Elk1 ETS transcription factor ELK1 IEA KEGG rno:04012 NCBI chr  X:3,692,367...3,709,252
Ensembl chr  X:3,693,293...3,709,249 		JBrowse link
G Epgn epithelial mitogen ISO RGD PMID:15982853 RGD:2317963 NCBI chr14:17,360,968...17,369,000
Ensembl chr14:17,360,968...17,369,000 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 ISO
IEA 		KEGG
PID
RGD		 PMID:15982853 PID:200159 rno:04012, RGD:2317963 NCBI chr10:83,907,491...83,931,365
Ensembl chr10:83,907,460...83,931,481 		JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 IMP
IEA
ISO 		Neuregulin stimulation of glucose transport in muscle cells KEGG
PID
RGD		 PMID:15007074 PMID:14711829 PMID:16829981 PMID:18519747 PID:200159 rno:04012, RGD:1642700, RGD:2289958, RGD:2317988, RGD:2317965 NCBI chr 7:1,579,079...1,600,379
Ensembl chr 7:1,579,816...1,601,120 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 ISO
IEA 		KEGG
RGD		 PMID:18519747 rno:04012, RGD:2317965 NCBI chr 9:76,973,386...78,045,633
Ensembl chr 9:76,973,227...78,045,772 		JBrowse link
G Ereg epiregulin ISO
IEA 		KEGG
PID
RGD		 PMID:15982853 PID:200159 rno:04012, RGD:2317963 NCBI chr14:17,311,485...17,325,260
Ensembl chr14:17,311,485...17,325,260 		JBrowse link
G Gab1 GRB2-associated binding protein 1 ISO
IEA 		PID
KEGG		 PID:200101 rno:04012 NCBI chr19:44,035,693...44,143,617
Ensembl chr19:44,035,063...44,143,617 		JBrowse link
G Gnai1 G protein subunit alpha i1 ISO PID PID:200101 NCBI chr 4:17,706,061...17,790,176
Ensembl chr 4:17,706,025...17,789,198 		JBrowse link
G Gnai3 G protein subunit alpha i3 ISO PID PID:200101 NCBI chr 2:198,430,920...198,468,874 JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 IMP RGD PMID:20445128 RGD:4892084 NCBI chr12:20,331,073...20,336,527
Ensembl chr12:20,327,679...20,337,144 		JBrowse link
G Grb2 growth factor receptor bound protein 2 ISO
IEA 		KEGG
PID
RGD		 PMID:16829981 PID:200101 rno:04012, RGD:2317988 NCBI chr10:101,380,354...101,448,138
Ensembl chr10:101,380,356...101,448,138 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta IEA KEGG rno:04012 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249 		JBrowse link
G Gsn gelsolin ISO PID PID:200101 NCBI chr 3:38,982,605...39,035,849
Ensembl chr 3:38,982,671...39,035,850 		JBrowse link
G Hbegf heparin-binding EGF-like growth factor ISO
IMP
IEA 		PID
KEGG
RGD		 PMID:15982853 PMID:15486316 PID:200159 rno:04012, RGD:2317963, RGD:1581908 NCBI chr18:28,380,337...28,390,220
Ensembl chr18:28,380,337...28,390,220 		JBrowse link
G Hras HRas proto-oncogene, GTPase ISO
IEA 		PID
KEGG		 PID:200101 rno:04012 NCBI chr 1:205,712,625...205,729,406
Ensembl chr 1:205,725,975...205,729,590 		JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 ISO PID PID:200159 NCBI chr 6:135,523,604...135,529,687
Ensembl chr 6:135,523,616...135,528,499 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit IEA KEGG rno:04012 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285 		JBrowse link
G Kras KRAS proto-oncogene, GTPase IEA KEGG rno:04012 NCBI chr 4:179,916,255...179,949,613
Ensembl chr 4:179,919,802...179,949,320 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 IEA KEGG rno:04012 NCBI chr 8:73,578,747...73,650,184
Ensembl chr 8:73,578,752...73,650,184 		JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 IEA KEGG rno:04012 NCBI chr 7:9,241,449...9,264,216
Ensembl chr 7:9,241,310...9,260,940 		JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 IEA KEGG rno:04012 NCBI chr10:50,842,348...50,947,063
Ensembl chr10:50,844,034...50,947,185 		JBrowse link
G Map2k7 mitogen activated protein kinase kinase 7 IEA KEGG rno:04012 NCBI chr12:7,389,032...7,398,377
Ensembl chr12:7,389,155...7,398,377 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 ISO
IEA 		PID
KEGG		 PID:200101 rno:04012 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk10 mitogen activated protein kinase 10 IEA KEGG rno:04012 NCBI chr14:6,802,247...7,094,103
Ensembl chr14:6,802,295...7,094,100 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 ISO
IEA 		PID
KEGG		 PID:200101 rno:04012 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 IEA KEGG rno:04012 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 IEA KEGG rno:04012 NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228 		JBrowse link
G Mtor mechanistic target of rapamycin kinase IEA KEGG rno:04012 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor IEA KEGG rno:04012 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028 		JBrowse link
G Nck1 NCK adaptor protein 1 ISO
IEA 		PID
KEGG		 PID:200101 rno:04012 NCBI chr 8:109,897,723...109,958,247
Ensembl chr 8:109,897,724...109,958,247 		JBrowse link
G Nck2 NCK adaptor protein 2 ISO
IEA 		PID
KEGG		 PID:200101 rno:04012 NCBI chr 9:53,206,006...53,332,417
Ensembl chr 9:53,231,381...53,332,394 		JBrowse link
G Nras NRAS proto-oncogene, GTPase ISO
IEA 		PID
KEGG		 PID:200101 rno:04012 NCBI chr 2:193,271,399...193,282,023
Ensembl chr 2:193,271,430...193,278,543 		JBrowse link
G Nrg1 neuregulin 1 ISO
IEA 		KEGG
RGD		 PMID:18519747 rno:04012, RGD:2317965 NCBI chr16:65,954,084...67,007,484
Ensembl chr16:65,953,865...66,999,849 		JBrowse link
G Nrg2 neuregulin 2 IDA
IEA
ISO 		KEGG
PID
RGD		 PMID:9348101 PMID:18519747 PID:200159 rno:04012, RGD:1304015, RGD:2317965 NCBI chr18:27,890,578...28,072,538
Ensembl chr18:27,890,578...28,072,538 		JBrowse link
G Nrg3 neuregulin 3 ISO
IEA 		KEGG
PID
RGD		 PMID:18519747 PID:200159 rno:04012, RGD:2317965 NCBI chr16:14,256,540...15,374,107
Ensembl chr16:14,257,148...15,374,147 		JBrowse link
G Nrg4 neuregulin 4 ISO
IEA 		KEGG
PID
RGD		 PMID:18519747 PID:200159 rno:04012, RGD:2317965 NCBI chr 8:64,483,559...64,555,671
Ensembl chr 8:64,488,722...64,573,439 		JBrowse link
G Pak1 p21 (RAC1) activated kinase 1 ISO
IEA 		PID
KEGG		 PID:200101 rno:04012 NCBI chr 1:161,522,399...161,637,623
Ensembl chr 1:161,491,847...161,637,612 		JBrowse link
G Pak2 p21 (RAC1) activated kinase 2 IEA KEGG rno:04012 NCBI chr11:82,212,896...82,273,803
Ensembl chr11:82,212,951...82,273,803 		JBrowse link
G Pak3 p21 (RAC1) activated kinase 3 IEA KEGG rno:04012 NCBI chr  X:111,912,967...112,171,037
Ensembl chr  X:111,913,059...112,165,035 		JBrowse link
G Pak4 p21 (RAC1) activated kinase 4 IEA KEGG rno:04012 NCBI chr 1:92,977,437...93,016,721
Ensembl chr 1:92,977,437...93,016,721 		JBrowse link
G Pak5 p21 (RAC1) activated kinase 5 IEA KEGG rno:04012 NCBI chr 3:143,848,404...144,156,674
Ensembl chr 3:143,849,223...144,156,640 		JBrowse link
G Pak6 p21 (RAC1) activated kinase 6 IEA KEGG rno:04012 NCBI chr 3:126,092,576...126,128,320
Ensembl chr 3:126,093,013...126,128,318 		JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 IMP Neuregulin stimulation of glucose transport in muscle cells RGD PMID:15007074 RGD:1642700 NCBI chr 3:77,113,464...77,144,145
Ensembl chr 3:77,113,473...77,144,145 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha ISO
IEA 		PID
KEGG		 PID:200101 rno:04012 NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:117,143,468...117,177,411 		JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta ISO
IEA 		PID
KEGG		 PID:200101 rno:04012 NCBI chr 8:108,474,017...108,579,140
Ensembl chr 8:108,474,019...108,579,331 		JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta ISO
IEA 		PID
KEGG		 PID:200101 rno:04012 NCBI chr 5:165,377,994...165,426,620
Ensembl chr 5:165,377,994...165,403,968 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 ISO
IEA 		KEGG
PID
RGD		 PMID:16829981 PID:200101 rno:04012, RGD:2317988 NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:34,612,946...34,626,347 		JBrowse link
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 ISO
IEA 		PID
KEGG		 PID:200101 rno:04012 NCBI chr16:18,699,389...18,708,045
Ensembl chr16:18,699,448...18,709,665 		JBrowse link
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 ISO
IEA 		PID
KEGG		 PID:200101 rno:04012 NCBI chr 5:134,936,790...135,009,303
Ensembl chr 5:134,934,857...135,007,762 		JBrowse link
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 IEA KEGG rno:04012 NCBI chr10:53,631,469...53,699,550
Ensembl chr10:53,631,476...53,699,539 		JBrowse link
G Pip5k1c phosphatidylinositol-4-phosphate 5-kinase type 1 gamma ISO PID PID:200101 NCBI chr 7:9,048,135...9,076,751
Ensembl chr 7:9,048,146...9,076,716 		JBrowse link
G Plcg1 phospholipase C, gamma 1 ISO
IEA 		PID
KEGG		 PID:200101 rno:04012 NCBI chr 3:169,805,299...169,836,040
Ensembl chr 3:169,804,846...169,836,050 		JBrowse link
G Plcg2 phospholipase C, gamma 2 IEA KEGG rno:04012 NCBI chr19:62,456,196...62,592,684
Ensembl chr19:62,453,259...62,592,684 		JBrowse link
G Prkca protein kinase C, alpha IEA KEGG rno:04012 NCBI chr10:93,388,991...93,787,617
Ensembl chr10:93,388,991...93,787,572 		JBrowse link
G Prkcb protein kinase C, beta IEA KEGG rno:04012 NCBI chr 1:186,263,397...186,594,743
Ensembl chr 1:186,263,447...186,594,740 		JBrowse link
G Prkcg protein kinase C, gamma IEA KEGG rno:04012 NCBI chr 1:74,748,272...74,777,611
Ensembl chr 1:74,748,272...74,774,814 		JBrowse link
G Prkcz protein kinase C, zeta IMP Neuregulin stimulation of glucose transport in muscle cells RGD PMID:15007074 RGD:1642700 NCBI chr 5:171,101,774...171,212,694
Ensembl chr 5:171,101,774...171,212,674 		JBrowse link
G Ptk2 protein tyrosine kinase 2 IEA KEGG rno:04012 NCBI chr 7:107,015,730...107,220,865
Ensembl chr 7:107,015,733...107,172,091 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 ISO PID PID:200101 NCBI chr 3:177,056,588...177,106,424
Ensembl chr 3:177,057,659...177,106,416 		JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 ISO PID PID:200101 NCBI chr12:41,026,079...41,085,577
Ensembl chr12:41,043,785...41,085,577 		JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 ISO PID PID:200101 NCBI chr 4:159,212,320...159,237,069
Ensembl chr 4:159,212,320...159,237,069 		JBrowse link
G Ptprj protein tyrosine phosphatase, receptor type, J ISO RGD PMID:16829981 RGD:2317988 NCBI chr 3:96,861,785...97,017,702
Ensembl chr 3:96,861,785...97,017,656 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase IEA KEGG rno:04012 NCBI chr 4:150,352,158...150,412,813
Ensembl chr 4:150,352,160...150,412,813 		JBrowse link
G Rasa1 RAS p21 protein activator 1 ISO PID PID:200101 NCBI chr 2:17,593,136...17,676,707
Ensembl chr 2:17,593,136...17,676,161 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 IEA KEGG rno:04012 NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,815,614...71,865,238 		JBrowse link
G Rps6kb2 ribosomal protein S6 kinase B2 IEA KEGG rno:04012 NCBI chr 1:210,880,824...210,887,556
Ensembl chr 1:210,880,825...210,887,562 		JBrowse link
G Shc1 SHC adaptor protein 1 ISO
IEA 		KEGG
RGD		 PMID:16829981 rno:04012, RGD:2317988 NCBI chr 2:177,135,649...177,147,257
Ensembl chr 2:177,135,659...177,147,914 		JBrowse link
G Shc2 SHC adaptor protein 2 IEA KEGG rno:04012 NCBI chr 7:10,717,320...10,739,539
Ensembl chr 7:10,717,320...10,739,539 		JBrowse link
G Shc3 SHC adaptor protein 3 IEA KEGG rno:04012 NCBI chr17:13,803,980...13,924,433
Ensembl chr17:13,803,781...13,924,433 		JBrowse link
G Shc4 SHC adaptor protein 4 IEA KEGG rno:04012 NCBI chr 3:133,334,026...133,428,404
Ensembl chr 3:133,334,034...133,427,826 		JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 IEP
IEA
ISO 		KEGG
PID
RGD		 PMID:8577724 PMID:16829981 PID:200101 rno:04012, RGD:1581110, RGD:2317988 NCBI chr 6:20,286,117...20,363,350
Ensembl chr 6:20,286,117...20,363,350 		JBrowse link
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 ISO
IEA 		KEGG
RGD		 PMID:16829981 rno:04012, RGD:2317988 NCBI chr 6:93,778,971...93,892,161
Ensembl chr 6:93,778,971...93,892,811 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase IEP
IEA
ISO 		KEGG
PID
RGD		 PMID:15856020 PID:200101 rno:04012, RGD:1581134 NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:166,511,985...166,559,462 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 ISO PID PID:200101 NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:56,911,523...57,077,346 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 ISO PID PID:200101 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359 		JBrowse link
G Stat5a signal transducer and activator of transcription 5A IEA KEGG rno:04012 NCBI chr10:86,285,859...86,310,187
Ensembl chr10:86,285,547...86,310,184 		JBrowse link
G Stat5b signal transducer and activator of transcription 5B IEA KEGG rno:04012 NCBI chr10:86,205,148...86,276,178
Ensembl chr10:86,207,293...86,275,990 		JBrowse link
G Tgfa transforming growth factor alpha ISO
IEA 		KEGG
PID
RGD		 PMID:15982853 PID:200159 rno:04012, RGD:2317963 NCBI chr 4:120,175,549...120,258,342
Ensembl chr 4:120,175,593...120,258,339 		JBrowse link
G Tln1 talin 1 ISO PID PID:200101 NCBI chr 5:62,583,730...62,613,687
Ensembl chr 5:62,583,731...62,613,687 		JBrowse link
G Wasl WASP like actin nucleation promoting factor ISO PID PID:200101 NCBI chr 4:54,049,081...54,097,653
Ensembl chr 4:54,049,082...54,097,570 		JBrowse link
altered epidermal growth factor/neuregulin signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Egf epidermal growth factor ISO RGD PMID:19506583 RGD:5490965 NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:220,893,660...220,976,297 		JBrowse link
G Egfr epidermal growth factor receptor ISO RGD PMID:20519133 PMID:20951313 PMID:19506583 RGD:5133241, RGD:5133242, RGD:5490965 NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 ISO RGD PMID:19078924 PMID:21277552 RGD:4143515, RGD:5133243 NCBI chr10:83,907,491...83,931,365
Ensembl chr10:83,907,460...83,931,481 		JBrowse link
G Tgfa transforming growth factor alpha ISO RGD PMID:19506583 RGD:5490965 NCBI chr 4:120,175,549...120,258,342
Ensembl chr 4:120,175,593...120,258,339 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    signaling pathway 2635
      growth factor signaling pathway 523
        epidermal growth factor/neuregulin signaling pathway 108
          altered epidermal growth factor/neuregulin signaling pathway 4
paths to the root