Nrg3 (neuregulin 3) - Rat Genome Database

Name: Nrg3
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Nrg3 (neuregulin 3) Rattus norvegicus

Analyze

Symbol:

Nrg3

Name:

neuregulin 3

RGD ID:

1559678

Description:

Predicted to enable chemorepellent activity. Predicted to be involved in ERBB4-ERBB4 signaling pathway; modulation of chemical synaptic transmission; and synapse assembly. Predicted to act upstream of or within several processes, including intracellular signal transduction; mammary placode formation; and regulation of cell migration. Predicted to be located in membrane. Predicted to be active in extracellular space and glutamatergic synapse. Orthologous to human NRG3 (neuregulin 3); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; INTERACTS WITH 3-chloropropane-1,2-diol; bisphenol A; glyphosate.

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

LOC498596; pro-neuregulin-3, membrane-bound isoform; RGD1559678; similar to neuregulin-3

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	NRG3 (neuregulin 3)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther
Mus musculus (house mouse):	Nrg3 (neuregulin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Nrg3 (neuregulin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	NRG3 (neuregulin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	NRG3 (neuregulin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	LOC101957192 (pro-neuregulin-3, membrane-bound isoform)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	NRG3 (neuregulin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	NRG3 (neuregulin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Nrg3 (neuregulin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	NRG3 (neuregulin 3)	Alliance	DIOPT (HGNC)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	16	14,229,270 - 15,352,505 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	14,235,157 - 15,352,368 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	16	15,763,031 - 16,932,208 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	15,764,632 - 15,798,974 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	15,661,430 - 16,817,319 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	14,679,903 - 15,817,157 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	16	14,466,369 - 15,581,462 (-)	NCBI		Celera
Cytogenetic Map	16	p14	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Hirschsprung's disease (ISO)

schizophrenia (ISO,ISS)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

3-chloropropane-1,2-diol (EXP)

4,4'-sulfonyldiphenol (ISO)

afimoxifene (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

casticin (ISO)

coumarin (ISO)

diarsenic trioxide (ISO)

dorsomorphin (ISO)

ethanol (ISO)

fulvestrant (ISO)

glyphosate (EXP)

lead(0) (ISO)

methylmercury chloride (ISO)

nickel atom (ISO)

PCB138 (ISO)

phenylmercury acetate (ISO)

SB 431542 (ISO)

trichostatin A (ISO)

triclosan (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

chemorepulsion involved in interneuron migration from the subpallium to the cortex (ISO)

ERBB4 signaling pathway (ISO)

ERBB4-ERBB4 signaling pathway (ISO)

intracellular signal transduction (ISO)

mammary gland development (ISO)

mammary placode formation (ISO)

modulation of chemical synaptic transmission (ISO)

negative regulation of neuron migration (ISO)

pattern specification process (ISO)

synapse assembly (ISO)

Cellular Component

extracellular space (ISO)

glutamatergic synapse (ISO)

membrane (IEA)

synapse (ISO)

Molecular Function

chemorepellent activity (ISO)

protein binding (ISO)

receptor ligand activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

epidermal growth factor/neuregulin signaling pathway (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Neuregulins and cancer.	Montero JC, etal., Clin Cancer Res. 2008 Jun 1;14(11):3237-41. doi: 10.1158/1078-0432.CCR-07-5133.
3.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
4.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	Comprehensive gene review and curation	RGD comprehensive gene curation

Additional References at PubMed

PMID:9275162	PMID:10723730	PMID:16140987	PMID:22376909	PMID:29114105	PMID:30328115

Genomics

Comparative Map Data

Nrg3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	16	14,229,270 - 15,352,505 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	14,235,157 - 15,352,368 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	16	15,763,031 - 16,932,208 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	15,764,632 - 15,798,974 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	15,661,430 - 16,817,319 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	14,679,903 - 15,817,157 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	16	14,466,369 - 15,581,462 (-)	NCBI		Celera
Cytogenetic Map	16	p14	NCBI

NRG3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	81,875,194 - 82,987,179 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	81,875,194 - 82,987,179 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	10	83,634,950 - 84,746,935 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	83,625,077 - 84,735,341 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	10	77,630,757 - 78,742,147 (+)	NCBI		Celera
Cytogenetic Map	10	q23.1	NCBI
HuRef	10	77,483,814 - 78,594,633 (+)	NCBI		HuRef
CHM1_1	10	83,917,602 - 85,028,760 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	10	82,749,017 - 83,860,555 (+)	NCBI		T2T-CHM13v2.0

Nrg3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	38,086,093 - 39,195,045 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	38,090,909 - 39,195,045 (-)	Ensembl		GRCm39 Ensembl
GRCm38	14	38,365,102 - 39,473,235 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	38,368,952 - 39,473,088 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	39,182,137 - 40,286,376 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	37,282,204 - 38,384,967 (-)	NCBI		MGSCv36	mm8
Celera	14	34,560,237 - 35,661,300 (-)	NCBI		Celera
Cytogenetic Map	14	B	NCBI

Nrg3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955510	1,615,316 - 2,618,617 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955510	1,615,316 - 2,620,031 (+)	NCBI	ChiLan1.0	ChiLan1.0

NRG3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	10	93,839,076 - 94,986,963 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	78,267,693 - 79,384,895 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	10	81,862,024 - 82,974,743 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	81,862,036 - 82,973,334 (+)	Ensembl	panpan1.1		panPan2

NRG3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	30,515,845 - 31,557,598 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	4	30,515,890 - 31,556,152 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	4	30,570,501 - 31,546,936 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	4	30,834,334 - 31,875,634 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	4	30,834,349 - 31,874,016 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	4	30,699,630 - 31,739,836 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	4	30,896,586 - 31,931,272 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	4	31,385,545 - 32,426,952 (+)	NCBI		UU_Cfam_GSD_1.0

LOC101957192
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	49,019,288 - 50,047,975 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936716	1,362,574 - 2,391,432 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NRG3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	83,317,019 - 84,402,943 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	83,316,962 - 84,405,347 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	90,842,758 - 91,108,804 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NRG3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	48,846,287 - 49,957,238 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666048	9,110,091 - 10,240,887 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Nrg3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624841	4,219,084 - 5,285,240 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624841	4,213,089 - 5,285,255 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Nrg3
7747 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	74
Count of miRNA genes:	54
Interacting mature miRNAs:	56
Transcripts:	ENSRNOT00000046842, ENSRNOT00000065946
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1600369	Hcas8	Hepatocarcinoma susceptibility QTL 8			liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	16	1	22477621	Rat
631830	Alc7	Alcohol consumption QTL 7	2.9		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	16	1	26727669	Rat
634355	Rends4	Renal damage susceptibility QTL 4		0.05	kidney blood vessel morphology trait (VT:0000530)	organ lesion measurement (CMO:0000677)	16	1	26727669	Rat
1582235	Insul8	Insulin level QTL 8	3.3	0.0063	blood insulin amount (VT:0001560)	calculated serum insulin level (CMO:0000359)	16	1	26727669	Rat
9590151	Scort8	Serum corticosterone level QTL 8	8.45	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	16	1	30836262	Rat
2302380	Slep6	Serum leptin concentration QTL 6	3.36		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	16	1	32139025	Rat
2307172	Activ4	Activity QTL 4	3.71	0.00023	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	16	1	33418960	Rat
1354584	Despr6	Despair related QTL 6	3.1	0.0067	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	16	1	39533930	Rat
2303566	Bw90	Body weight QTL 90	2		body mass (VT:0001259)	body weight (CMO:0000012)	16	1	39533930	Rat
631561	Hcuc2	Hepatic copper content QTL 2	2.8		liver copper amount (VT:0003065)	liver total copper weight (CMO:0001507)	16	1	39533949	Rat
6903319	Bw114	Body weight QTL 114	2.7	0.0037	body mass (VT:0001259)	body weight (CMO:0000012)	16	1	43534949	Rat
7411664	Foco30	Food consumption QTL 30	11	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	16	1	44588133	Rat
1354625	Despr7	Despair related QTL 7	3.16	0.016	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	16	1	44977551	Rat
1600378	Arunc4	Aerobic running capacity QTL 4		0.03	exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	16	380245	80345693	Rat
2293343	Glom16	Glomerulus QTL 16	7.4		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	16	832236	46053497	Rat
2312660	Bw95	Body weight QTL 95		0.05	inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	16	832236	59492508	Rat
2312663	Slep9	Serum leptin concentration QTL 9		0.001	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	16	832236	59492508	Rat
2312666	Insul16	Insulin level QTL 16		0.01	blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	16	832236	59492508	Rat
2312669	Stl23	Serum triglyceride level QTL 23		0.01	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	16	832236	59492508	Rat
2301406	Kidm39	Kidney mass QTL 39		0.002	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	16	2851709	15884239	Rat
1300133	Rf24	Renal function QTL 24	3.64		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	16	3380150	21361552	Rat
2306902	Bp339	Blood pressure QTL 339		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	16	3380150	43025077	Rat
737825	Alc13	Alcohol consumption QTL 13	4.5		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	16	4227609	16039848	Rat
70183	BpQTLcluster13	Blood pressure QTL cluster 13	3.654		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	16	4227609	43025077	Rat
70183	BpQTLcluster13	Blood pressure QTL cluster 13	3.654		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	16	4227609	43025077	Rat
70183	BpQTLcluster13	Blood pressure QTL cluster 13	3.654		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	16	4227609	43025077	Rat
737819	Hcas4	Hepatocarcinoma susceptibility QTL 4	4.43		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	16	4227609	46975965	Rat
61405	Niddm6	Non-insulin dependent diabetes mellitus QTL 6	3.66	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	16	4227609	48972724	Rat
61338	Bp23	Blood pressure QTL 23	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	16	4227609	49227609	Rat
737826	Alc11	Alcohol consumption QTL 11	3.2		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	16	4227609	60252231	Rat
61372	Bp40	Blood pressure QTL 40	2.2		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	16	4227730	17696785	Rat

Markers in Region

D16Got15

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	16	14,809,226 - 14,809,357 (+)	MAPPER	mRatBN7.2
Rnor_6.0	16	16,381,383 - 16,381,513	NCBI	Rnor6.0
Rnor_5.0	16	16,270,747 - 16,270,877	UniSTS	Rnor5.0
RGSC_v3.4	16	15,267,951 - 15,268,082	RGD	RGSC3.4
RGSC_v3.4	16	15,267,952 - 15,268,082	UniSTS	RGSC3.4
RGSC_v3.1	16	15,267,950 - 15,268,080	RGD
Celera	16	15,039,042 - 15,039,172	UniSTS
RH 3.4 Map	16	132.5	UniSTS
RH 3.4 Map	16	132.5	RGD
RH 2.0 Map	16	92.9	RGD
Cytogenetic Map	16	p14	UniSTS

D16Got101

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	16	15,085,394 - 15,085,632 (+)	MAPPER	mRatBN7.2
Rnor_6.0	16	16,659,553 - 16,659,790	NCBI	Rnor6.0
Rnor_5.0	16	16,548,851 - 16,549,088	UniSTS	Rnor5.0
RGSC_v3.4	16	15,547,850 - 15,548,087	UniSTS	RGSC3.4
Celera	16	15,314,900 - 15,315,137	UniSTS
Cytogenetic Map	16	p14	UniSTS

BF412035

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	16	14,499,115 - 14,499,330 (+)	MAPPER	mRatBN7.2
Rnor_6.0	16	16,029,664 - 16,029,878	NCBI	Rnor6.0
Rnor_5.0	16	15,927,226 - 15,927,440	UniSTS	Rnor5.0
RGSC_v3.4	16	14,950,282 - 14,950,496	UniSTS	RGSC3.4
Celera	16	14,729,871 - 14,730,085	UniSTS
RH 3.4 Map	16	126.1	UniSTS
Cytogenetic Map	16	p14	UniSTS

RH138878

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	16	14,605,047 - 14,605,231 (+)	MAPPER	mRatBN7.2
Rnor_6.0	16	16,166,733 - 16,166,916	NCBI	Rnor6.0
Rnor_5.0	16	16,056,547 - 16,056,730	UniSTS	Rnor5.0
RGSC_v3.4	16	15,059,615 - 15,059,798	UniSTS	RGSC3.4
Celera	16	14,835,871 - 14,836,054	UniSTS
RH 3.4 Map	16	126.7	UniSTS
Cytogenetic Map	16	p14	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium									54		7
Low			2						18		2
Below cutoff	2	12	8	2	5	2	6	7	2	14	23	5	6

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_017587628	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017600398	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039095027	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039095028	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039095029	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039095030	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039095031	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039095032	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039095033	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474031	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000274	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000046842 ⟹ ENSRNOP00000042884

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	16	15,764,632 - 15,798,974 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000065946 ⟹ ENSRNOP00000059751

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	16	15,764,632 - 15,798,974 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000099299 ⟹ ENSRNOP00000077709

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	16	14,235,157 - 15,352,368 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000111170 ⟹ ENSRNOP00000080898

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	16	14,235,157 - 15,352,368 (-)	Ensembl

RefSeq Acc Id:

XM_017600398 ⟹ XP_017455887

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	16	14,229,270 - 15,352,505 (-)	NCBI
Rnor_6.0	16	15,763,031 - 16,932,208 (-)	NCBI

Sequence:

show sequence

ATGGGTATAAGTGTATATTTGGGGCAGGGCCGGTGGCCTCGTTCACTGGTGCGCGTTCGGCAGC
CGCCGTTGTTGTTAGGAGGGTCGCGGCGGCTTTGTTGTGTTGGCGCCCCGCGTCGGGGCGGCCG
GGCGGGCCCGGACGGCGGCGGAGAAGGGAGCGGGACCGAACCCNCGGAGTTAAGCTGTAGCGAC
TGCATCGTGGAACCGGGCAGCATGACGTGGNTGTGCGTGGTGCCTCTGTTCATCGGCTTCATCG
GCCTGGGGCTCAGCCTCATGCTGCTTAAATGGATCGTTGTAGGCTCCGTCAAGAGTACGTGCGC
CACCGACTTGGTGGAATCCAAGGGAATGGGCCAGGACCCCTTCTTCCTCTCCAAGNCCAGCTCG
TTCCCCAAGGCTATGGAAACCACCACCACAACTACTTCTACCACGTCCCCCGCCACCCCCTCTA
CCGGCGGCGCTGCTTCTTCCAGGACGCCTAACCGGATTAGCACCCGCTTGACCACCATCACGCG
GGCACCCACCCGCTTCCCTGGGCACCGGGTGCCCATCCGGGCTAGCCCGCGCTCTACGACCGCA
CGGAACACTGCTGCCCCTCCGACGGTCCTGTCCACCACGTCCCCTTTCTTCAGTAGCAGCACGC
CAGGCTCCCGACCCCCGATGCCAGGAGCCCCCAGTACGCAGGCGATGCCTTCCTGGCCCACTGC
AGCGTATGCTACCTCCTCCTATCTCCACGACTCCACTCCCTCCTGGACCCTATCACCCTTTCAG
GATGCTGCCGCCGCCTCTTCCTCCTCACCCTCTTCCACCTCCTCCACCACCACCACCACCCCAG
AAACTAGCACCAGCCCCAAATTTCATACTACAACATACTCCACTGAACGATCTGAGCACTTCAA
ACCCTGTCGAGACAAGGACCTGGCGTATTGTCTCAATGACGGTGAATGCTTTGTGATTGAGACC
CTGACAGGATCCCATAAGCACTGTCGGTGCAAGGAAGGCTACCAAGGAGTCCGTTGTGATCAAT
TTCTGCCGAAAACTGACTCCATCTTATCGGATCCAACAGACCACTTGGGGATTGAATTCATGGA
GAGTGAAGACGTTTATCAAAGGCAGGTGCTGTCAATTTCATGTATCATCTTTGGAATTGTCATC
GTGGGCATGTTCTGTGCTGCCTTCTACTTCAAAAGCAAAAAACAAGCTAAACAAATCCAGGAGC
ATCTGAAAGAATCGCAGAATGGGAAAAATTACAGCCTGAAGGCATCCAGCACAATGACGAAGTC
TGAGAGCTTGATGAAGAGCCATGTCCAACTACAAAATTATTCCAAGGCAGATAGGCATCCTGTG
ACTGCGCTGGAGAAAATAATGGAGTCAAGTTTTACAGCTCCCCAGTTGTTCCCAGAGGTTACTT
CTGACCGAGGAAGCCAGCCTATCAAGCACCACAGCAGAAGTATTTCTTCTTGTGGCAGCCCAGG
ACAAAGGAGTGGGATGTTGCATAGGAATACTTTCAGAAGGACACCACCCTCACCCCGAAGTCGA
CTGGGTGGTATTGTAGGACCAGCATATCAACAACTTGAAGAATCAAGAATTCCAGACCAGGATA
CGATACCTTGCCAAGGGATAGAGGTCAGGAAGACTATATCCCACCTGCCTATACAGCTGTGGTG
TGTTGAAAGACCCCTGGACTTAAAGTATGCATCCAATGGTTTAAGAACCCAACAAAATGCATCA
ATAAATATGCAACTGCCTTCAAGAGAGACAAACCCCTATTTTAATAGCTTGGATCAAAAGGACC
TGGTGGGTTATTTATCCCCAAGGGCCAATTCGGTGCCCATCATCCCGTCGGTGGGTCTAGAAGA
AACCTGCATGCAAATGCCAGGGATTTCTGACGTCAAAAGCATTAAATGGTGCAAAAACTCCTAC
TCTGCTGACATTGTCAATGCGAGTATTCCAGTCAGCGATTGTCTTCTAGAAGAACAGCAAGAAG
TGAAAATATTACTAGAGACCGTGCAGGAACAGATCCGGATTCTGACTGATGCCAGACGGTCAGA
AGACTACGAACTGGCCAGCATGGAAACTGAGGATAGTGCGAGCGAAAACACAGCCTTTCTCCCT
CTGAGTCCCACGGCCAAATCAGAACGAGAGGCACAATTTGTCTTAAGAAATGAAATTCAAAGAG
ACTCTGTGCTAACCAAGTGACTGGAGATGTAGGGATCTGTGCATTCTATGCTTTGCTTAACAGG
AAGGAGAGGAAATTAAATACAAATTATTTATATGCATTAATTTAAGAGCATCTACTTAGAAGAA
ACCAAATAGTCTGCCGCCCTCATATCATAGTGTTTTTTAACAAAATATTTTTTTAAAGGGAAAG
AAGCGTTTCAGGAGTGATAAAGCTTACCACTAAAGCTTTAGGGGAGAATTCTGAATCCAATTTC
AGTTAGTCCTTACACTGTCCTCTTTGGCTCTTGGAAGATTTGGCAAATTCCAACCTTTGGTCCC
ATACTGCCAGTGTCTATATAAAAAAGAAACTGGTGTTCTCCTAGTGTCAAAGAGATGAAGTTTA
TTCCAAGGGCATATGTGCCAGTTAAACAGATAGTCCTGGCCATTTGACTCTTGAGTTCCAACCC
CTAAATTTCTCTTCATCAATGCTCTCTCTACAGGCTACGTCATGTCAAGGAATGTAGTGCTTTG
TATTTGATTTTCAAAGAATGGCAAGAAAACATGAGCAGGAGGGAAGACAGAAAATAGGAGTAAT
CCGGGCAAAACTAGCTACTCTCATGTGCCATTTTTCTCTGTAATTGAAAGCACAGAATCTCAGA
GGGAGGTGTGAAATTATTGTAGGAAAAGAGACAAAATGACAGCGTCGTGTTACTAAAATCATGC
TAATAGAAATGTTTTACTCGGAGAGTGTTTAGAAGCTCTGAAAGGGCACCTCTGTGTGTGTGTG
TGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGCTCGCGCGCGCGCGCACCTGTGTGCACAGG
TGTGAGGGCGCAAGTGTTGTGGCCTTGCTCACCCAAGCACATATGCTATATGCACATGTGTTCC
CTGTACGTATGTGTGTGCATGTGTGTGTGTGTGTGTATTAAAGCTTGCTAAAATTTGTTCTGAA
ACATCAGGGAAGCTAATATTCAGAAGAGATTTCCCCCTTTAGATCTTTTCACTTTAAATTTTCC
ATTAAATGTAAATTTGGTTAGCGAGTTCTTGAACCAAGGTAACTTGCATGGTGGGGTCTTACAA
AACTCTTGACAATGTTTAGACCATTTTCTGATGTGAATAATATTTAAAAGGATAGCCTTTGGCT
GGTGGAAATCAGCATCACAAAGCAAATTAATGGAGGATGTGTTTATTTTGAATCATTTAACTTA
AATTATTGGCACAAGCCAATCATCAAATTGACAGTTGACTATTTTATTTCTCGTCATCCTCATT
GCTAATTTACAGCAAGTCTGCTCCGTGTAGACAGAAGCACTGGCTTCTGTGGTTAACATGGAAG
GAATAAATTGTTGAAAATCACAAATCCCAGACTATTCAGTTCACAAGCAATGCCCCCAAGCAAC
AAATTGTGTTGTATGTTCATTTGGAATAAAGCAATATTTTTACCACTGCTAAGGTGAACTGAAA
CCTCTCCTGAAGACGTGTCTGTTTTATTTTCCCTTCTTTTCGTGGGGCATTCAAGGAAACTAGT
GTTCACATACCCAGTCTCTATCCAATTATTGGTGGTGTTGTTATGTTTACACTGTTTAAAATAA
AAAGGCACAGTATTTGAAAGT

hide sequence

RefSeq Acc Id:

XM_039095027 ⟹ XP_038950955

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	16	14,229,270 - 15,352,505 (-)	NCBI

RefSeq Acc Id:

XM_039095028 ⟹ XP_038950956

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	16	14,229,270 - 15,352,505 (-)	NCBI

RefSeq Acc Id:

XM_039095029 ⟹ XP_038950957

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	16	14,229,270 - 15,352,505 (-)	NCBI

RefSeq Acc Id:

XM_039095030 ⟹ XP_038950958

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	16	14,229,270 - 15,352,505 (-)	NCBI

RefSeq Acc Id:

XM_039095031 ⟹ XP_038950959

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	16	14,229,270 - 15,352,505 (-)	NCBI

RefSeq Acc Id:

XM_039095032 ⟹ XP_038950960

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	16	14,229,270 - 15,352,505 (-)	NCBI

RefSeq Acc Id:

XM_039095033 ⟹ XP_038950961

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	16	14,229,270 - 15,352,505 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_017455887	(Get FASTA)	NCBI Sequence Viewer
	XP_038950955	(Get FASTA)	NCBI Sequence Viewer
	XP_038950956	(Get FASTA)	NCBI Sequence Viewer
	XP_038950957	(Get FASTA)	NCBI Sequence Viewer
	XP_038950958	(Get FASTA)	NCBI Sequence Viewer
	XP_038950959	(Get FASTA)	NCBI Sequence Viewer
	XP_038950960	(Get FASTA)	NCBI Sequence Viewer
	XP_038950961	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL90888	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_017455887 ⟸ XM_017600398
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I5Y1H8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGISVYLGQGRWPRSLVRVRQPPLLLGGSRRLCCVGAPRRGGRAGPDGGGEGSGTEPXELSCSD CIVEPGSMTWXCVVPLFIGFIGLGLSLMLLKWIVVGSVKSTCATDLVESKGMGQDPFFLSKXSS FPKAMETTTTTTSTTSPATPSTGGAASSRTPNRISTRLTTITRAPTRFPGHRVPIRASPRSTTA RNTAAPPTVLSTTSPFFSSSTPGSRPPMPGAPSTQAMPSWPTAAYATSSYLHDSTPSWTLSPFQ DAAAASSSSPSSTSSTTTTTPETSTSPKFHTTTYSTERSEHFKPCRDKDLAYCLNDGECFVIET LTGSHKHCRCKEGYQGVRCDQFLPKTDSILSDPTDHLGIEFMESEDVYQRQVLSISCIIFGIVI VGMFCAAFYFKSKKQAKQIQEHLKESQNGKNYSLKASSTMTKSESLMKSHVQLQNYSKADRHPV TALEKIMESSFTAPQLFPEVTSDRGSQPIKHHSRSISSCGSPGQRSGMLHRNTFRRTPPSPRSR LGGIVGPAYQQLEESRIPDQDTIPCQGIEVRKTISHLPIQLWCVERPLDLKYASNGLRTQQNAS INMQLPSRETNPYFNSLDQKDLVGYLSPRANSVPIIPSVGLEETCMQMPGISDVKSIKWCKNSY SADIVNASIPVSDCLLEEQQEVKILLETVQEQIRILTDARRSEDYELASMETEDSASENTAFLP LSPTAKSEREAQFVLRNEIQRDSVLTK hide sequence

RefSeq Acc Id:

ENSRNOP00000059751 ⟸ ENSRNOT00000065946

RefSeq Acc Id:

ENSRNOP00000042884 ⟸ ENSRNOT00000046842

RefSeq Acc Id:	XP_038950957 ⟸ XM_039095029
- Peptide Label:	isoform X4
- UniProtKB:	A0A8I5Y1H8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038950961 ⟸ XM_039095033
- Peptide Label:	isoform X8
- UniProtKB:	A0A8I5Y1H8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038950960 ⟸ XM_039095032
- Peptide Label:	isoform X7
- UniProtKB:	A0A8I5Y1H8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038950956 ⟸ XM_039095028
- Peptide Label:	isoform X3
- UniProtKB:	A0A8I5Y1H8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038950959 ⟸ XM_039095031
- Peptide Label:	isoform X6
- UniProtKB:	A0A8I5Y1H8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038950955 ⟸ XM_039095027
- Peptide Label:	isoform X2
- UniProtKB:	A0A8I5Y1H8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038950958 ⟸ XM_039095030
- Peptide Label:	isoform X5
- UniProtKB:	A0A8I5ZU04 (UniProtKB/TrEMBL), A0A8I5Y1H8 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSRNOP00000077709 ⟸ ENSRNOT00000099299

RefSeq Acc Id:

ENSRNOP00000080898 ⟸ ENSRNOT00000111170

Protein Domains

EGF-like

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F1M182-F1-model_v2	AlphaFold	F1M182	1-369	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1559678	AgrOrtholog
BioCyc Gene	G2FUF-11959	BioCyc
Ensembl Genes	ENSRNOG00000033894	Ensembl
	ENSRNOG00000063450	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000077709	ENTREZGENE
	ENSRNOP00000077709.1	UniProtKB/TrEMBL
	ENSRNOP00000080898	ENTREZGENE
	ENSRNOP00000080898.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000099299	ENTREZGENE
	ENSRNOT00000099299.1	UniProtKB/TrEMBL
	ENSRNOT00000111170	ENTREZGENE
	ENSRNOT00000111170.1	UniProtKB/TrEMBL
Gene3D-CATH	Laminin	UniProtKB/TrEMBL
InterPro	EGF-like_dom	UniProtKB/TrEMBL
	Neuregulin	UniProtKB/TrEMBL
NCBI Gene	498596	ENTREZGENE
PANTHER	PRO-NEUREGULIN-3, MEMBRANE-BOUND ISOFORM	UniProtKB/TrEMBL
	PTHR11100	UniProtKB/TrEMBL
PhenoGen	Nrg3	PhenoGen
PROSITE	EGF_1	UniProtKB/TrEMBL
	EGF_2	UniProtKB/TrEMBL
	EGF_3	UniProtKB/TrEMBL
Superfamily-SCOP	EGF/Laminin	UniProtKB/TrEMBL
UniProt	A0A8I5Y1H8	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I5ZU04	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2022-06-02	Nrg3	neuregulin 3	Nrg3	neuregulin 3	Data Merged	737654	PROVISIONAL
2021-08-09	Nrg3	neuregulin 3			Symbol and Name status set to provisional	45752	PROVISIONAL
2008-02-28	Nrg3	neuregulin 3	RGD1559678_predicted	similar to neuregulin-3 (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-07	RGD1559678_predicted	similar to neuregulin-3 (predicted)	LOC498596	similar to neuregulin-3	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC498596	similar to neuregulin-3			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)