Abl2 (ABL proto-oncogene 2, non-receptor tyrosine kinase) - Rat Genome Database

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Gene: Abl2 (ABL proto-oncogene 2, non-receptor tyrosine kinase) Rattus norvegicus
Analyze
Symbol: Abl2
Name: ABL proto-oncogene 2, non-receptor tyrosine kinase
RGD ID: 1590898
Description: Predicted to enable metal ion binding activity; phosphotyrosine residue binding activity; and protein tyrosine kinase activity. Predicted to be involved in several processes, including cellular response to retinoic acid; positive regulation of establishment of T cell polarity; and synapse maturation. Predicted to act upstream of or within several processes, including T cell differentiation; nervous system development; and regulation of signal transduction. Predicted to be located in several cellular components, including dendritic spine; lamellipodium; and phagocytic cup. Predicted to be active in glutamatergic synapse; plasma membrane; and postsynapse. Orthologous to human ABL2 (ABL proto-oncogene 2, non-receptor tyrosine kinase); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; myocarditis pathway; INTERACTS WITH bisphenol A; C60 fullerene; dopamine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Abelson murine leukemia viral (v-abl) oncogene homolog 2; Abelson murine leukemia viral (v-abl) oncogene homolog 2 (Abelson-related gene); Abelson murine leukemia viral (v-abl) oncogene homolog 2 (mapped); Abelson tyrosine-protein kinase 2; Abl1-related gene product; Abl2_mapped; Abll; Arg; arg tyrosine kinase; c-abl oncogene 2, non-receptor tyrosine kinase; tyrosine-protein kinase ABL2; v-abl Abelson murine leukemia viral oncogene 2; v-abl Abelson murine leukemia viral oncogene homolog 2; v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81371,223,902 - 71,319,770 (+)NCBIGRCr8
mRatBN7.21368,673,702 - 68,770,846 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1368,673,722 - 68,839,742 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1371,260,527 - 71,356,363 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01372,580,546 - 72,675,673 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01369,842,041 - 69,937,159 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01374,154,533 - 74,333,244 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1374,154,835 - 74,333,244 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01379,074,821 - 79,253,783 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41371,546,918 - 71,915,301 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1368,537,724 - 68,702,946 (+)NCBICelera
Cytogenetic Map13q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,1-dichloroethene  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-hydroxypropanoic acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
alpha-pinene  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP)
bisphenol F  (ISO)
boron nitride  (ISO)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
caffeine  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
diclofenac  (ISO)
dopamine  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
fenoldopam  (EXP)
fluoranthene  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
indometacin  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
methapyrilene  (ISO)
methylisothiazolinone  (ISO)
N,N-diethyl-m-toluamide  (EXP)
nickel atom  (ISO)
ozone  (ISO)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
permethrin  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
ponatinib  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
rac-lactic acid  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
taurine  (ISO)
testosterone  (ISO)
theophylline  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
triphenyl phosphate  (ISO)
tungsten  (ISO)
valproic acid  (EXP)
xylitol  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (ISO)
actin filament bundle assembly  (ISO)
actin filament organization  (ISO)
adult walking behavior  (ISO)
aggressive behavior  (ISO)
alpha-beta T cell differentiation  (ISO)
auditory behavior  (ISO)
Bergmann glial cell differentiation  (ISO)
biological_process  (ND)
canonical NF-kappaB signal transduction  (ISO)
cell-cell adhesion  (ISO)
cellular response to retinoic acid  (ISO)
cerebellum morphogenesis  (ISO)
circulatory system development  (ISO)
dendrite morphogenesis  (ISO)
dendritic spine maintenance  (ISO)
DN4 thymocyte differentiation  (ISO)
epidermal growth factor receptor signaling pathway  (IBA,ISO)
establishment of localization in cell  (ISO)
exploration behavior  (ISO)
learning  (ISO)
multicellular organism growth  (ISO)
negative regulation of cell-cell adhesion  (ISO)
negative regulation of endothelial cell apoptotic process  (ISO)
negative regulation of Rho protein signal transduction  (ISO)
neural tube closure  (ISO)
neuroepithelial cell differentiation  (ISO)
neuromuscular process controlling balance  (ISO)
neuron differentiation  (ISO)
neuron remodeling  (ISO)
phagocytosis  (ISO)
phospholipase C-activating G protein-coupled receptor signaling pathway  (ISO)
platelet-derived growth factor receptor signaling pathway  (ISO)
positive regulation of canonical NF-kappaB signal transduction  (ISO)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of establishment of T cell polarity  (ISO)
positive regulation of interleukin-2 production  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of T cell migration  (ISO)
positive regulation of type II interferon production  (ISO)
positive regulation of Wnt signaling pathway, planar cell polarity pathway  (ISO)
post-embryonic development  (ISO)
protein localization  (ISO)
regulation of extracellular matrix organization  (ISO)
Rho protein signal transduction  (ISO)
substrate-dependent cell migration, cell extension  (ISO)
synapse maturation  (ISO)
visual learning  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Comprehensive gene review and curation RGD comprehensive gene curation
7. Nomenclature for N-acetyltransferases. Vatsis KP, etal., Pharmacogenetics 1995 Feb;5(1):1-17.
Additional References at PubMed
PMID:9883720   PMID:11752434   PMID:12748290   PMID:12796783   PMID:12893824   PMID:15084284   PMID:15886098   PMID:16831423   PMID:17910947   PMID:18025176   PMID:18827006   PMID:19414610  
PMID:19805386   PMID:20624904   PMID:20837657   PMID:20980600   PMID:22357865   PMID:22665498   PMID:22810897   PMID:23100514   PMID:23365224   PMID:23595732   PMID:23840065   PMID:24367707  
PMID:27335408   PMID:32399753  


Genomics

Comparative Map Data
Abl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81371,223,902 - 71,319,770 (+)NCBIGRCr8
mRatBN7.21368,673,702 - 68,770,846 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1368,673,722 - 68,839,742 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1371,260,527 - 71,356,363 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01372,580,546 - 72,675,673 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01369,842,041 - 69,937,159 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01374,154,533 - 74,333,244 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1374,154,835 - 74,333,244 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01379,074,821 - 79,253,783 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41371,546,918 - 71,915,301 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1368,537,724 - 68,702,946 (+)NCBICelera
Cytogenetic Map13q22NCBI
ABL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381179,099,330 - 179,229,677 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1179,099,330 - 179,229,684 (-)EnsemblGRCh38hg38GRCh38
GRCh371179,068,465 - 179,198,812 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361177,335,085 - 177,465,390 (-)NCBINCBI36Build 36hg18NCBI36
Build 341175,808,413 - 175,930,393NCBI
Celera1152,177,312 - 152,307,714 (-)NCBICelera
Cytogenetic Map1q25.2NCBI
HuRef1150,296,029 - 150,426,165 (-)NCBIHuRef
CHM1_11180,492,111 - 180,622,356 (-)NCBICHM1_1
T2T-CHM13v2.01178,454,335 - 178,584,699 (-)NCBIT2T-CHM13v2.0
Abl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391156,386,160 - 156,477,189 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1156,386,356 - 156,477,138 (+)EnsemblGRCm39 Ensembl
GRCm381156,558,590 - 156,649,619 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1156,558,786 - 156,649,568 (+)EnsemblGRCm38mm10GRCm38
MGSCv371158,488,918 - 158,579,750 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361158,395,726 - 158,479,393 (+)NCBIMGSCv36mm8
Celera1158,949,003 - 159,040,041 (+)NCBICelera
Cytogenetic Map1G3NCBI
cM Map167.71NCBI
Abl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540618,437,672 - 18,527,698 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540618,435,984 - 18,527,967 (-)NCBIChiLan1.0ChiLan1.0
ABL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2170,530,839 - 70,660,797 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1170,195,232 - 70,322,490 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01154,586,423 - 154,711,621 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11158,275,334 - 158,313,954 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1158,280,994 - 158,313,915 (-)Ensemblpanpan1.1panPan2
ABL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1720,696,659 - 20,735,362 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl720,700,144 - 20,727,410 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha720,144,587 - 20,259,861 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0720,356,575 - 20,471,864 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl720,356,795 - 20,463,911 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1720,263,283 - 20,379,080 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0720,371,214 - 20,487,250 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0720,506,417 - 20,622,140 (+)NCBIUU_Cfam_GSD_1.0
Abl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934491,923,100 - 92,008,043 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364819,824,392 - 9,847,104 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364819,823,790 - 9,847,291 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9120,892,952 - 120,984,695 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19120,888,891 - 120,984,724 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29132,663,636 - 132,782,743 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ABL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12550,106,621 - 50,244,002 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2550,216,483 - 50,241,621 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605551,607,771 - 51,778,370 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Abl2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247713,160,224 - 3,278,787 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247713,160,528 - 3,280,860 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Abl2
381 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:71
Count of miRNA genes:63
Interacting mature miRNAs:69
Transcripts:ENSRNOT00000059524
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132369296968692969Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132369296968692969Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133228447177284471Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
12879444Bp397Blood pressure QTL 397arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134504940490049404Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134551471990514719Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134619797684753113Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
2303028Bp329Blood pressure QTL 329arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)135849787273485113Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)135949252277046890Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)135987440885581182Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat

Markers in Region
D13Got50  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21368,812,686 - 68,812,819 (+)MAPPERmRatBN7.2
Rnor_6.01374,291,196 - 74,291,328NCBIRnor6.0
Rnor_5.01379,212,839 - 79,212,971UniSTSRnor5.0
RGSC_v3.41371,888,265 - 71,888,398RGDRGSC3.4
RGSC_v3.41371,888,266 - 71,888,398UniSTSRGSC3.4
RGSC_v3.11371,902,453 - 71,902,586RGD
Celera1368,675,960 - 68,676,092UniSTS
Cytogenetic Map13q22UniSTS
RH132874  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21368,803,818 - 68,804,002 (+)MAPPERmRatBN7.2
Rnor_6.01374,282,329 - 74,282,512NCBIRnor6.0
Rnor_5.01379,203,972 - 79,204,155UniSTSRnor5.0
RGSC_v3.41371,879,399 - 71,879,582UniSTSRGSC3.4
Celera1368,667,092 - 68,667,275UniSTS
Cytogenetic Map13q22UniSTS
AA925877  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21368,769,234 - 68,769,337 (+)MAPPERmRatBN7.2
Rnor_6.01374,247,741 - 74,247,843NCBIRnor6.0
Rnor_5.01379,169,384 - 79,169,486UniSTSRnor5.0
RGSC_v3.41371,844,939 - 71,845,041UniSTSRGSC3.4
Celera1368,632,515 - 68,632,617UniSTS
RH 3.4 Map13392.6UniSTS
Cytogenetic Map13q22UniSTS
BI274170  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21368,801,979 - 68,802,149 (+)MAPPERmRatBN7.2
Rnor_6.01374,280,490 - 74,280,659NCBIRnor6.0
Rnor_5.01379,202,133 - 79,202,302UniSTSRnor5.0
RGSC_v3.41371,877,560 - 71,877,729UniSTSRGSC3.4
Celera1368,665,253 - 68,665,422UniSTS
RH 3.4 Map13393.7UniSTS
Cytogenetic Map13q22UniSTS
BI282517  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21368,801,762 - 68,801,926 (+)MAPPERmRatBN7.2
Rnor_6.01374,280,273 - 74,280,436NCBIRnor6.0
Rnor_5.01379,201,916 - 79,202,079UniSTSRnor5.0
RGSC_v3.41371,877,343 - 71,877,506UniSTSRGSC3.4
Celera1368,665,036 - 68,665,199UniSTS
RH 3.4 Map13375.2UniSTS
Cytogenetic Map13q22UniSTS
AA801206  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21368,769,252 - 68,769,468 (+)MAPPERmRatBN7.2
Rnor_6.01374,247,759 - 74,247,974NCBIRnor6.0
Rnor_5.01379,169,402 - 79,169,617UniSTSRnor5.0
RGSC_v3.41371,844,957 - 71,845,172UniSTSRGSC3.4
Celera1368,632,533 - 68,632,748UniSTS
RH 3.4 Map13390.7UniSTS
Cytogenetic Map13q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 4 12 2 9 2 58 10 24 8
Low 3 39 44 38 10 38 8 11 16 25 17 3 8
Below cutoff 1 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001395130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006250047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006250048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006250049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006250050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006250051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006250052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006250053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006250054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006250055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272327 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272329 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000059524   ⟹   ENSRNOP00000056281
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1368,674,022 - 68,839,742 (+)Ensembl
Rnor_6.0 Ensembl1374,154,835 - 74,333,244 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000102486   ⟹   ENSRNOP00000096793
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1368,673,765 - 68,765,104 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000104990   ⟹   ENSRNOP00000082517
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1368,673,992 - 68,765,104 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000106669   ⟹   ENSRNOP00000082815
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1368,673,722 - 68,765,104 (+)Ensembl
RefSeq Acc Id: NM_001395130   ⟹   NP_001382059
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81371,223,949 - 71,319,770 (+)NCBI
mRatBN7.21368,673,753 - 68,769,593 (+)NCBI
RefSeq Acc Id: XM_006250047   ⟹   XP_006250109
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81371,223,903 - 71,319,770 (+)NCBI
mRatBN7.21368,674,022 - 68,763,730 (+)NCBI
Rnor_6.01374,154,835 - 74,242,238 (+)NCBI
Rnor_5.01379,074,821 - 79,253,783 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006250049   ⟹   XP_006250111
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81371,285,456 - 71,319,770 (+)NCBI
mRatBN7.21368,737,429 - 68,763,730 (+)NCBI
Rnor_6.01374,216,845 - 74,242,238 (+)NCBI
Rnor_5.01379,074,821 - 79,253,783 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006250051   ⟹   XP_006250113
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81371,223,903 - 71,319,770 (+)NCBI
mRatBN7.21368,674,022 - 68,763,730 (+)NCBI
Rnor_6.01374,154,835 - 74,242,238 (+)NCBI
Rnor_5.01379,074,821 - 79,253,783 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006250052   ⟹   XP_006250114
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81371,223,903 - 71,319,770 (+)NCBI
mRatBN7.21368,673,703 - 68,770,846 (+)NCBI
Rnor_6.01374,154,533 - 74,248,042 (+)NCBI
Rnor_5.01379,074,821 - 79,253,783 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006250053   ⟹   XP_006250115
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81371,223,904 - 71,319,770 (+)NCBI
mRatBN7.21368,673,704 - 68,770,846 (+)NCBI
Rnor_6.01374,154,533 - 74,248,042 (+)NCBI
Rnor_5.01379,074,821 - 79,253,783 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006250054   ⟹   XP_006250116
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81371,285,457 - 71,319,770 (+)NCBI
mRatBN7.21368,737,433 - 68,770,846 (+)NCBI
Rnor_6.01374,215,870 - 74,248,042 (+)NCBI
Rnor_5.01379,074,821 - 79,253,783 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006250055   ⟹   XP_006250117
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81371,223,904 - 71,319,770 (+)NCBI
mRatBN7.21368,673,703 - 68,770,846 (+)NCBI
Rnor_6.01374,154,533 - 74,248,042 (+)NCBI
Rnor_5.01379,074,821 - 79,253,783 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063272324   ⟹   XP_063128394
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81371,285,454 - 71,319,770 (+)NCBI
RefSeq Acc Id: XM_063272325   ⟹   XP_063128395
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81371,223,902 - 71,319,770 (+)NCBI
RefSeq Acc Id: XM_063272327   ⟹   XP_063128397
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81371,224,436 - 71,319,770 (+)NCBI
RefSeq Acc Id: XM_063272328   ⟹   XP_063128398
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81371,235,953 - 71,319,770 (+)NCBI
RefSeq Acc Id: XM_063272329   ⟹   XP_063128399
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81371,302,119 - 71,319,770 (+)NCBI
RefSeq Acc Id: XP_006250109   ⟸   XM_006250047
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZXU9 (UniProtKB/TrEMBL),   A6ID14 (UniProtKB/TrEMBL),   F1M0N1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250113   ⟸   XM_006250051
- Peptide Label: isoform X5
- UniProtKB: A0A8I6GM88 (UniProtKB/TrEMBL),   A6ID14 (UniProtKB/TrEMBL),   F1M0N1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250114   ⟸   XM_006250052
- Peptide Label: isoform X7
- UniProtKB: A0A8I5ZY28 (UniProtKB/TrEMBL),   A6ID14 (UniProtKB/TrEMBL),   F1M0N1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250115   ⟸   XM_006250053
- Peptide Label: isoform X8
- UniProtKB: A6ID14 (UniProtKB/TrEMBL),   F1M0N1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250117   ⟸   XM_006250055
- Peptide Label: isoform X10
- UniProtKB: A6ID14 (UniProtKB/TrEMBL),   F1M0N1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250111   ⟸   XM_006250049
- Peptide Label: isoform X3
- UniProtKB: A6ID14 (UniProtKB/TrEMBL),   F1M0N1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250116   ⟸   XM_006250054
- Peptide Label: isoform X9
- UniProtKB: A6ID14 (UniProtKB/TrEMBL),   F1M0N1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000056281   ⟸   ENSRNOT00000059524
RefSeq Acc Id: ENSRNOP00000082517   ⟸   ENSRNOT00000104990
RefSeq Acc Id: ENSRNOP00000096793   ⟸   ENSRNOT00000102486
RefSeq Acc Id: ENSRNOP00000082815   ⟸   ENSRNOT00000106669
RefSeq Acc Id: NP_001382059   ⟸   NM_001395130
- UniProtKB: A6ID14 (UniProtKB/TrEMBL),   F1M0N1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128395   ⟸   XM_063272325
- Peptide Label: isoform X4
- UniProtKB: A6ID14 (UniProtKB/TrEMBL),   F1M0N1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128397   ⟸   XM_063272327
- Peptide Label: isoform X6
- UniProtKB: A6ID14 (UniProtKB/TrEMBL),   F1M0N1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128398   ⟸   XM_063272328
- Peptide Label: isoform X11
RefSeq Acc Id: XP_063128394   ⟸   XM_063272324
- Peptide Label: isoform X2
- UniProtKB: A6ID14 (UniProtKB/TrEMBL),   F1M0N1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128399   ⟸   XM_063272329
- Peptide Label: isoform X12
Protein Domains
Protein kinase   SH2   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M0N1-F1-model_v2 AlphaFold F1M0N1 1-1208 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1590898 AgrOrtholog
BioCyc Gene G2FUF-17810 BioCyc
Ensembl Genes ENSRNOG00000004305 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000059524.4 UniProtKB/TrEMBL
  ENSRNOT00000102486.1 UniProtKB/TrEMBL
  ENSRNOT00000104990.1 UniProtKB/TrEMBL
  ENSRNOT00000106669.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.505.10 UniProtKB/TrEMBL
  Nucleotidyltransferases domain 2 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro ABL_SH2 UniProtKB/TrEMBL
  F-actin_binding UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  SH3-like_dom UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
KEGG Report rno:304883 UniProtKB/TrEMBL
NCBI Gene 304883 ENTREZGENE
PANTHER TYROSINE-PROTEIN KINASE UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE ABL2 UniProtKB/TrEMBL
Pfam F_actin_bind UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
PhenoGen Abl2 PhenoGen
PRINTS SH2DOMAIN UniProtKB/TrEMBL
  TYRKINASE UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004305 RatGTEx
SMART FABD UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
  SSF50044 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
UniProt A0A8I5ZXU9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZY28 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GM88 ENTREZGENE, UniProtKB/TrEMBL
  A6ID14 ENTREZGENE, UniProtKB/TrEMBL
  F1M0N1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-07-09 Abl2  ABL proto-oncogene 2, non-receptor tyrosine kinase  Abl2  c-abl oncogene 2, non-receptor tyrosine kinase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-07-18 Abl2  c-abl oncogene 2, non-receptor tyrosine kinase  Abl2  v-abl Abelson murine leukemia viral oncogene homolog 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-07-28 Abl2  v-abl Abelson murine leukemia viral oncogene homolog 2  Abl2  v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-10 Abl2  v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)  Abl2  v-abl Abelson murine leukemia viral oncogene 2   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-26 Abl2  v-abl Abelson murine leukemia viral oncogene 2   Abl2  Abelson murine leukemia viral (v-abl) oncogene homolog 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-04-12   Abelson murine leukemia viral (v-abl) oncogene homolog 2  Abl2  Abelson murine leukemia viral (v-abl) oncogene homolog 2 (mapped)  Name updated 737654 APPROVED
2007-04-05 Abl2  Abelson murine leukemia viral (v-abl) oncogene homolog 2 (mapped)  Abl2_mapped  Abelson murine leukemia viral (v-abl) oncogene homolog 2 (mapped)  Data merged from RGD:2009 737654 APPROVED
2006-11-20 Abl2  Abelson murine leukemia viral (v-abl) oncogene homolog 2 (mapped)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Abl2_mapped  Abelson murine leukemia viral (v-abl) oncogene homolog 2 (mapped)  Abl2  Abelson murine leukemia viral (v-abl) oncogene homolog 2  Symbol and Name updated 1556543 APPROVED
2002-11-06 Abl2  Abelson murine leukemia viral (v-abl) oncogene homolog 2    Abelson murine leukemia viral (v-abl) oncogene homolog 2 (Abelson-related gene)  Name updated 625702 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation induction of expression by thyroid hormone does not require beta-adrenergic pathways