Abl2 (ABL proto-oncogene 2, non-receptor tyrosine kinase) - Rat Genome Database

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Gene: Abl2 (ABL proto-oncogene 2, non-receptor tyrosine kinase) Rattus norvegicus
Analyze
Symbol: Abl2
Name: ABL proto-oncogene 2, non-receptor tyrosine kinase
RGD ID: 1590898
Description: Predicted to enable metal ion binding activity; phosphotyrosine residue binding activity; and protein tyrosine kinase activity. Predicted to be involved in several processes, including cellular response to retinoic acid; peptidyl-tyrosine phosphorylation; and synapse maturation. Predicted to act upstream of or within several processes, including nervous system development; regulation of signal transduction; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to be located in several cellular components, including dendritic spine; lamellipodium; and phagocytic cup. Predicted to be active in glutamatergic synapse and postsynapse. Orthologous to human ABL2 (ABL proto-oncogene 2, non-receptor tyrosine kinase); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; myocarditis pathway; INTERACTS WITH bisphenol A; C60 fullerene; dopamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Abelson murine leukemia viral (v-abl) oncogene homolog 2; Abelson murine leukemia viral (v-abl) oncogene homolog 2 (Abelson-related gene); Abelson murine leukemia viral (v-abl) oncogene homolog 2 (mapped); Abelson tyrosine-protein kinase 2; Abl1-related gene product; Abl2_mapped; Abll; Arg; arg tyrosine kinase; c-abl oncogene 2, non-receptor tyrosine kinase; tyrosine-protein kinase ABL2; v-abl Abelson murine leukemia viral oncogene 2; v-abl Abelson murine leukemia viral oncogene homolog 2; v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21368,673,702 - 68,839,742 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1368,673,722 - 68,839,742 (+)Ensembl
Rnor_6.01374,154,533 - 74,333,244 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1374,154,835 - 74,333,244 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01379,074,821 - 79,253,783 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41371,546,918 - 71,915,301 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1368,537,724 - 68,702,946 (+)NCBICelera
Cytogenetic Map13q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (ISO)
actin filament bundle assembly  (ISO)
actin filament organization  (ISO)
adult walking behavior  (ISO)
aggressive behavior  (ISO)
alpha-beta T cell differentiation  (ISO)
auditory behavior  (ISO)
Bergmann glial cell differentiation  (ISO)
biological_process  (ND)
cellular protein localization  (ISO)
cellular response to retinoic acid  (ISO)
cerebellum morphogenesis  (ISO)
circulatory system development  (ISO)
dendrite morphogenesis  (ISO)
dendritic spine maintenance  (ISO)
epidermal growth factor receptor signaling pathway  (ISO)
exploration behavior  (ISO)
learning  (ISO)
multicellular organism growth  (ISO)
negative regulation of cell-cell adhesion  (ISO)
negative regulation of endothelial cell apoptotic process  (ISO)
negative regulation of Rho protein signal transduction  (ISO)
neural tube closure  (ISO)
neuroepithelial cell differentiation  (ISO)
neuromuscular process controlling balance  (ISO)
neuron differentiation  (ISO)
neuron remodeling  (ISO)
peptidyl-tyrosine phosphorylation  (ISO)
phagocytosis  (ISO)
platelet-derived growth factor receptor signaling pathway  (ISO)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (ISO)
positive regulation of interferon-gamma production  (ISO)
positive regulation of interleukin-2 production  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of oxidoreductase activity  (ISO)
positive regulation of phospholipase C activity  (ISO)
positive regulation of protein binding  (ISO)
positive regulation of Wnt signaling pathway, planar cell polarity pathway  (ISO)
post-embryonic development  (ISO)
protein phosphorylation  (ISO)
regulation of extracellular matrix organization  (ISO)
reproductive process  (ISO)
substrate-dependent cell migration, cell extension  (ISO)
synapse maturation  (ISO)
visual learning  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:9883720   PMID:11752434   PMID:12748290   PMID:12796783   PMID:12893824   PMID:15084284   PMID:15886098   PMID:16831423   PMID:17910947   PMID:18025176   PMID:18827006   PMID:19414610  
PMID:19805386   PMID:20624904   PMID:20837657   PMID:20980600   PMID:22357865   PMID:22665498   PMID:23100514   PMID:23365224   PMID:23595732   PMID:23840065   PMID:24367707   PMID:27335408  
PMID:32399753  


Genomics

Comparative Map Data
Abl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21368,673,702 - 68,839,742 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1368,673,722 - 68,839,742 (+)Ensembl
Rnor_6.01374,154,533 - 74,333,244 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1374,154,835 - 74,333,244 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01379,074,821 - 79,253,783 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41371,546,918 - 71,915,301 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1368,537,724 - 68,702,946 (+)NCBICelera
Cytogenetic Map13q22NCBI
ABL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1179,099,330 - 179,229,684 (-)EnsemblGRCh38hg38GRCh38
GRCh381179,099,330 - 179,229,693 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371179,068,465 - 179,198,812 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361177,335,085 - 177,465,390 (-)NCBINCBI36hg18NCBI36
Build 341175,808,413 - 175,930,393NCBI
Celera1152,177,312 - 152,307,714 (-)NCBI
Cytogenetic Map1q25.2NCBI
HuRef1150,296,029 - 150,426,165 (-)NCBIHuRef
CHM1_11180,492,111 - 180,622,356 (-)NCBICHM1_1
Abl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391156,386,160 - 156,477,189 (+)NCBIGRCm39mm39
GRCm39 Ensembl1156,386,356 - 156,477,138 (+)Ensembl
GRCm381156,558,590 - 156,649,619 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1156,558,786 - 156,649,568 (+)EnsemblGRCm38mm10GRCm38
MGSCv371158,488,918 - 158,579,750 (+)NCBIGRCm37mm9NCBIm37
MGSCv361158,395,726 - 158,479,393 (+)NCBImm8
Celera1158,949,003 - 159,040,041 (+)NCBICelera
Cytogenetic Map1G3NCBI
cM Map167.71NCBI
Abl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540618,437,672 - 18,527,698 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540618,435,984 - 18,527,967 (-)NCBIChiLan1.0ChiLan1.0
ABL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11158,275,334 - 158,313,954 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1158,280,994 - 158,313,915 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01154,586,423 - 154,711,621 (-)NCBIMhudiblu_PPA_v0panPan3
ABL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1720,696,659 - 20,735,362 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl720,700,144 - 20,727,410 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha720,144,587 - 20,259,861 (+)NCBI
ROS_Cfam_1.0720,356,575 - 20,471,864 (+)NCBI
UMICH_Zoey_3.1720,263,283 - 20,379,080 (+)NCBI
UNSW_CanFamBas_1.0720,371,214 - 20,487,250 (+)NCBI
UU_Cfam_GSD_1.0720,506,417 - 20,622,140 (+)NCBI
Abl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934491,923,100 - 92,008,043 (+)NCBI
SpeTri2.0NW_0049364819,823,790 - 9,847,291 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9120,892,926 - 120,985,119 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19120,888,891 - 120,984,724 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29132,663,636 - 132,782,743 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ABL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12550,106,621 - 50,244,002 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2550,216,483 - 50,241,621 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605551,607,771 - 51,778,370 (+)NCBIVero_WHO_p1.0
Abl2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247713,160,528 - 3,280,860 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
D13Got50  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21368,812,686 - 68,812,819 (+)MAPPERmRatBN7.2
Rnor_6.01374,291,196 - 74,291,328NCBIRnor6.0
Rnor_5.01379,212,839 - 79,212,971UniSTSRnor5.0
RGSC_v3.41371,888,265 - 71,888,398RGDRGSC3.4
RGSC_v3.41371,888,266 - 71,888,398UniSTSRGSC3.4
RGSC_v3.11371,902,453 - 71,902,586RGD
Celera1368,675,960 - 68,676,092UniSTS
Cytogenetic Map13q22UniSTS
RH132874  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21368,803,818 - 68,804,002 (+)MAPPERmRatBN7.2
Rnor_6.01374,282,329 - 74,282,512NCBIRnor6.0
Rnor_5.01379,203,972 - 79,204,155UniSTSRnor5.0
RGSC_v3.41371,879,399 - 71,879,582UniSTSRGSC3.4
Celera1368,667,092 - 68,667,275UniSTS
Cytogenetic Map13q22UniSTS
AA925877  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21368,769,234 - 68,769,337 (+)MAPPERmRatBN7.2
Rnor_6.01374,247,741 - 74,247,843NCBIRnor6.0
Rnor_5.01379,169,384 - 79,169,486UniSTSRnor5.0
RGSC_v3.41371,844,939 - 71,845,041UniSTSRGSC3.4
Celera1368,632,515 - 68,632,617UniSTS
RH 3.4 Map13392.6UniSTS
Cytogenetic Map13q22UniSTS
BI274170  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21368,801,979 - 68,802,149 (+)MAPPERmRatBN7.2
Rnor_6.01374,280,490 - 74,280,659NCBIRnor6.0
Rnor_5.01379,202,133 - 79,202,302UniSTSRnor5.0
RGSC_v3.41371,877,560 - 71,877,729UniSTSRGSC3.4
Celera1368,665,253 - 68,665,422UniSTS
RH 3.4 Map13393.7UniSTS
Cytogenetic Map13q22UniSTS
BI282517  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21368,801,762 - 68,801,926 (+)MAPPERmRatBN7.2
Rnor_6.01374,280,273 - 74,280,436NCBIRnor6.0
Rnor_5.01379,201,916 - 79,202,079UniSTSRnor5.0
RGSC_v3.41371,877,343 - 71,877,506UniSTSRGSC3.4
Celera1368,665,036 - 68,665,199UniSTS
RH 3.4 Map13375.2UniSTS
Cytogenetic Map13q22UniSTS
AA801206  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21368,769,252 - 68,769,468 (+)MAPPERmRatBN7.2
Rnor_6.01374,247,759 - 74,247,974NCBIRnor6.0
Rnor_5.01379,169,402 - 79,169,617UniSTSRnor5.0
RGSC_v3.41371,844,957 - 71,845,172UniSTSRGSC3.4
Celera1368,632,533 - 68,632,748UniSTS
RH 3.4 Map13390.7UniSTS
Cytogenetic Map13q22UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132369296968692969Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132369296968692969Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133228447177284471Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
4889861Pur29Proteinuria QTL 2913.80.005total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
12879444Bp397Blood pressure QTL 397arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134504940490049404Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134551471990514719Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134619797684753113Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
2303028Bp329Blood pressure QTL 329arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)135849787273485113Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)135949252277046890Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)135987440885581182Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:71
Count of miRNA genes:63
Interacting mature miRNAs:69
Transcripts:ENSRNOT00000059524
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 4 12 2 9 2 58 10 24 8
Low 3 39 44 38 10 38 8 11 16 25 17 3 8
Below cutoff 1 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001107186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001395130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006250046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006250047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006250048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006250049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006250050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006250051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006250052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006250053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006250054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006250055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090738 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090746 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000059524   ⟹   ENSRNOP00000056281
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1368,674,022 - 68,839,742 (+)Ensembl
Rnor_6.0 Ensembl1374,154,835 - 74,333,244 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000102486   ⟹   ENSRNOP00000096793
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1368,673,765 - 68,765,104 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000104990   ⟹   ENSRNOP00000082517
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1368,673,992 - 68,765,104 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000106669   ⟹   ENSRNOP00000082815
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1368,673,722 - 68,765,104 (+)Ensembl
RefSeq Acc Id: NM_001107186   ⟹   NP_001100656
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21368,674,022 - 68,839,742 (+)NCBI
Rnor_6.01374,154,835 - 74,333,244 (+)NCBI
Rnor_5.01379,074,821 - 79,253,783 (+)NCBI
RGSC_v3.41371,546,918 - 71,915,301 (+)RGD
Celera1368,537,724 - 68,702,946 (+)RGD
Sequence:
RefSeq Acc Id: XM_006250046   ⟹   XP_006250108
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21368,674,022 - 68,763,730 (+)NCBI
Rnor_6.01374,154,835 - 74,248,042 (+)NCBI
Rnor_5.01379,074,821 - 79,253,783 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006250047   ⟹   XP_006250109
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21368,674,022 - 68,763,730 (+)NCBI
Rnor_6.01374,154,835 - 74,242,238 (+)NCBI
Rnor_5.01379,074,821 - 79,253,783 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006250049   ⟹   XP_006250111
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21368,737,429 - 68,763,730 (+)NCBI
Rnor_6.01374,216,845 - 74,242,238 (+)NCBI
Rnor_5.01379,074,821 - 79,253,783 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006250051   ⟹   XP_006250113
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21368,674,022 - 68,763,730 (+)NCBI
Rnor_6.01374,154,835 - 74,242,238 (+)NCBI
Rnor_5.01379,074,821 - 79,253,783 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006250052   ⟹   XP_006250114
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21368,673,703 - 68,770,846 (+)NCBI
Rnor_6.01374,154,533 - 74,248,042 (+)NCBI
Rnor_5.01379,074,821 - 79,253,783 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006250053   ⟹   XP_006250115
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21368,673,704 - 68,770,846 (+)NCBI
Rnor_6.01374,154,533 - 74,248,042 (+)NCBI
Rnor_5.01379,074,821 - 79,253,783 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006250054   ⟹   XP_006250116
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21368,737,433 - 68,770,846 (+)NCBI
Rnor_6.01374,215,870 - 74,248,042 (+)NCBI
Rnor_5.01379,074,821 - 79,253,783 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006250055   ⟹   XP_006250117
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21368,673,703 - 68,770,846 (+)NCBI
Rnor_6.01374,154,533 - 74,248,042 (+)NCBI
Rnor_5.01379,074,821 - 79,253,783 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039090738   ⟹   XP_038946666
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21368,673,702 - 68,770,846 (+)NCBI
RefSeq Acc Id: XM_039090740   ⟹   XP_038946668
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21368,673,703 - 68,770,846 (+)NCBI
RefSeq Acc Id: XM_039090741   ⟹   XP_038946669
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21368,737,424 - 68,770,846 (+)NCBI
RefSeq Acc Id: XM_039090742   ⟹   XP_038946670
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21368,673,702 - 68,770,846 (+)NCBI
RefSeq Acc Id: XM_039090743   ⟹   XP_038946671
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21368,674,242 - 68,770,846 (+)NCBI
RefSeq Acc Id: XM_039090744   ⟹   XP_038946672
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21368,673,703 - 68,770,846 (+)NCBI
RefSeq Acc Id: XM_039090746   ⟹   XP_038946674
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21368,751,938 - 68,770,846 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_001100656   ⟸   NM_001107186
- Sequence:
RefSeq Acc Id: XP_006250108   ⟸   XM_006250046
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006250109   ⟸   XM_006250047
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_006250113   ⟸   XM_006250051
- Peptide Label: isoform X9
- Sequence:
RefSeq Acc Id: XP_006250114   ⟸   XM_006250052
- Peptide Label: isoform X11
- Sequence:
RefSeq Acc Id: XP_006250115   ⟸   XM_006250053
- Peptide Label: isoform X12
- Sequence:
RefSeq Acc Id: XP_006250117   ⟸   XM_006250055
- Peptide Label: isoform X14
- Sequence:
RefSeq Acc Id: XP_006250111   ⟸   XM_006250049
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_006250116   ⟸   XM_006250054
- Peptide Label: isoform X13
- Sequence:
RefSeq Acc Id: ENSRNOP00000056281   ⟸   ENSRNOT00000059524
RefSeq Acc Id: XP_038946666   ⟸   XM_039090738
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038946670   ⟸   XM_039090742
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038946672   ⟸   XM_039090744
- Peptide Label: isoform X10
RefSeq Acc Id: XP_038946668   ⟸   XM_039090740
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038946671   ⟸   XM_039090743
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038946669   ⟸   XM_039090741
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038946674   ⟸   XM_039090746
- Peptide Label: isoform X15
RefSeq Acc Id: ENSRNOP00000082517   ⟸   ENSRNOT00000104990
RefSeq Acc Id: ENSRNOP00000096793   ⟸   ENSRNOT00000102486
RefSeq Acc Id: ENSRNOP00000082815   ⟸   ENSRNOT00000106669
Protein Domains
Protein kinase   SH2   SH3

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN-Lx/CubMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BUF/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
DA/OlaHsd (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
F344/Stm (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FXLE16/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/FarMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
HXB10/IpcvMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEXF10A/StmMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrcAek (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrcAek (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrcAek (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
M520/NRrrcMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MWF/Hsd (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/OlalpcvMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/RijCrl (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1590898 AgrOrtholog
Ensembl Genes ENSRNOG00000004305 Ensembl, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000056281 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000059524 UniProtKB/TrEMBL
Gene3D-CATH 3.30.505.10 UniProtKB/TrEMBL
InterPro ABL_SH2 UniProtKB/TrEMBL
  F-actin_binding UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  SH3-like_dom UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
KEGG Report rno:304883 UniProtKB/TrEMBL
NCBI Gene 304883 ENTREZGENE
Pfam F_actin_bind UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
PhenoGen Abl2 PhenoGen
PRINTS SH2DOMAIN UniProtKB/TrEMBL
  TYRKINASE UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
SMART FABD UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
  SSF50044 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
UniProt F1M0N1_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-07-09 Abl2  ABL proto-oncogene 2, non-receptor tyrosine kinase  Abl2  c-abl oncogene 2, non-receptor tyrosine kinase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-07-18 Abl2  c-abl oncogene 2, non-receptor tyrosine kinase  Abl2  v-abl Abelson murine leukemia viral oncogene homolog 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-07-28 Abl2  v-abl Abelson murine leukemia viral oncogene homolog 2  Abl2  v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-10 Abl2  v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)  Abl2  v-abl Abelson murine leukemia viral oncogene 2   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-26 Abl2  v-abl Abelson murine leukemia viral oncogene 2   Abl2  Abelson murine leukemia viral (v-abl) oncogene homolog 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-04-12   Abelson murine leukemia viral (v-abl) oncogene homolog 2  Abl2  Abelson murine leukemia viral (v-abl) oncogene homolog 2 (mapped)  Name updated 737654 APPROVED
2007-04-05 Abl2  Abelson murine leukemia viral (v-abl) oncogene homolog 2 (mapped)  Abl2_mapped  Abelson murine leukemia viral (v-abl) oncogene homolog 2 (mapped)  Data Merged 737654 APPROVED
2006-11-20 Abl2  Abelson murine leukemia viral (v-abl) oncogene homolog 2 (mapped)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Abl2_mapped  Abelson murine leukemia viral (v-abl) oncogene homolog 2 (mapped)  Abl2  Abelson murine leukemia viral (v-abl) oncogene homolog 2  Symbol and Name updated 1556543 APPROVED
2002-11-06 Abl2  Abelson murine leukemia viral (v-abl) oncogene homolog 2    Abelson murine leukemia viral (v-abl) oncogene homolog 2 (Abelson-related gene)  Name updated 625702 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation induction of expression by thyroid hormone does not require beta-adrenergic pathways