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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:sulindac
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Accession:CHEBI:9352 term browser browse the term
Definition:A monocarboxylic acid that is 1-benzylidene-1H-indene which is substituted at positions 2, 3, and 5 by methyl, carboxymethyl, and fluorine respectively, and in which the phenyl group of the benzylidene moiety is substituted at the para position by a methylsulfinyl group. It is a prodrug for the corresponding sulfide, a non-steroidal anti-inflammatory drug, used particularly in the treatment of acute and chronic inflammatory conditions.
Synonyms:exact_synonym: {(1Z)-5-fluoro-2-methyl-1-[4-(methylsulfinyl)benzylidene]-1H-inden-3-yl}acetic acid
 related_synonym: (Z)-5-Fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid;   Clinoril;   Formula=C20H17FO3S;   InChI=1S/C20H17FO3S/c1-12-17(9-13-3-6-15(7-4-13)25(2)24)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9-;   InChIKey=MLKXDPUZXIRXEP-MFOYZWKCSA-N;   SMILES=CC1=C(CC(O)=O)c2cc(F)ccc2C\\1=C/c1ccc(cc1)S(C)=O;   Sulindacum;   cis-5-Fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid;   cis-5-Fluoro-2-methyl-1-((p-methylsulfinyl)benzylidene)indene-3-acetic acid;   sulindaco
 xref: Beilstein:2951842;   CAS:38194-50-2;   DrugBank:DB00605;   Drug_Central:2534;   HMDB:HMDB0014743;   KEGG:C01531;   KEGG:D00120
 xref_mesh: MESH:D013467
 xref: PDBeChem:SUZ;   PMID:11569947;   PMID:11927004;   PMID:12406542;   PMID:15020200;   PMID:15123337;   PMID:19884509;   PMID:23689354;   PMID:23804703;   Patent:DE2039426;   Patent:US3654349;   Reaxys:2951842;   Wikipedia:Sulindac


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sulindac term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 increases expression
multiple interactions		 ISO Sulindac results in increased expression of ABCC1 protein
Acetylcysteine inhibits the reaction [Sulindac results in increased expression of ABCC1 protein]		 CTD PMID:11820781 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [Sulindac results in increased expression of ABCC3 protein] CTD PMID:11820781 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Abcd3 ATP binding cassette subfamily D member 3 increases expression EXP Sulindac results in increased expression of ABCD3 mRNA CTD PMID:24136188 NCBI chr 2:209,852,087...209,905,763
Ensembl chr 2:209,852,087...209,906,020 		JBrowse link
G Abhd16a abhydrolase domain containing 16A, phospholipase increases expression EXP Sulindac results in increased expression of ABHD16A mRNA CTD PMID:24136188 NCBI chr20:3,719,089...3,733,952
Ensembl chr20:3,719,091...3,733,927 		JBrowse link
G Abi1 abl-interactor 1 decreases expression EXP Sulindac results in decreased expression of ABI1 mRNA CTD PMID:24136188 NCBI chr17:85,098,837...85,179,829
Ensembl chr17:85,098,550...85,179,792 		JBrowse link
G Acaca acetyl-CoA carboxylase alpha increases expression ISO Sulindac results in increased expression of ACACA mRNA CTD PMID:32535746 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457 		JBrowse link
G Acad9 acyl-CoA dehydrogenase family, member 9 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of ACAD9 mRNA CTD PMID:20371263 NCBI chr 2:118,943,170...118,966,150
Ensembl chr 2:118,943,174...118,966,547 		JBrowse link
G Ace2 angiotensin converting enzyme 2 decreases expression ISO
EXP		 Sulindac results in decreased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Acly ATP citrate lyase increases expression ISO Sulindac results in increased expression of ACLY mRNA CTD PMID:32535746 NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320 		JBrowse link
G Acp2 acid phosphatase 2, lysosomal increases expression ISO Sulindac results in increased expression of ACP2 mRNA CTD PMID:11906190 NCBI chr 3:77,175,022...77,185,180
Ensembl chr 3:77,175,895...77,185,680 		JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of ACSL1 mRNA CTD PMID:20371263 NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541 		JBrowse link
G Actr10 actin related protein 10 decreases expression EXP Sulindac results in decreased expression of ACTR10 mRNA CTD PMID:24136188 NCBI chr 6:89,446,141...89,472,350
Ensembl chr 6:89,446,093...89,473,047 		JBrowse link
G Acy1 aminoacylase 1 increases expression EXP Sulindac results in increased expression of ACY1 mRNA CTD PMID:24136188 NCBI chr 8:107,072,354...107,077,756
Ensembl chr 8:107,072,358...107,077,682 		JBrowse link
G Add1 adducin 1 increases expression EXP Sulindac results in increased expression of ADD1 mRNA CTD PMID:24136188 NCBI chr14:76,108,643...76,167,267
Ensembl chr14:76,108,654...76,167,182 		JBrowse link
G Adhfe1 alcohol dehydrogenase, iron containing, 1 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of ADHFE1 mRNA CTD PMID:20371263 NCBI chr 5:9,705,966...9,732,580
Ensembl chr 5:9,705,970...9,732,517 		JBrowse link
G Adipor2 adiponectin receptor 2 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of ADIPOR2 mRNA CTD PMID:20371263 NCBI chr 4:152,524,604...152,588,848
Ensembl chr 4:152,524,623...152,559,355 		JBrowse link
G Adss2 adenylosuccinate synthase 2 increases expression EXP Sulindac results in increased expression of ADSS2 mRNA CTD PMID:24136188 NCBI chr13:89,769,240...89,799,577
Ensembl chr13:89,769,244...89,799,604 		JBrowse link
G Ahr aryl hydrocarbon receptor increases localization
multiple interactions		 ISO
EXP		 Sulindac results in increased localization of AHR protein
Sulindac binds to and results in increased activity of AHR protein		 CTD PMID:16531450 PMID:17985343 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Aif1l allograft inflammatory factor 1-like decreases expression ISO Sulindac results in decreased expression of AIF1L mRNA CTD PMID:11906190 NCBI chr 3:15,229,476...15,254,033
Ensembl chr 3:15,229,524...15,254,023 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 affects localization ISO Sulindac affects the localization of AIFM1 protein CTD PMID:15946692 PMID:17136320 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256 		JBrowse link
G Aifm2 apoptosis inducing factor, mitochondria associated 2 increases expression ISO Sulindac results in increased expression of AIFM2 mRNA CTD PMID:11906190 NCBI chr20:29,654,283...29,679,239
Ensembl chr20:29,652,927...29,679,236 		JBrowse link
G Akap1 A-kinase anchoring protein 1 increases expression EXP Sulindac results in increased expression of AKAP1 mRNA CTD PMID:24136188 NCBI chr10:73,621,021...73,654,123
Ensembl chr10:73,621,883...73,653,896 		JBrowse link
G Akap9 A-kinase anchoring protein 9 decreases expression EXP Sulindac results in decreased expression of AKAP9 mRNA CTD PMID:24136188 NCBI chr 4:30,056,738...30,192,716
Ensembl chr 4:30,056,738...30,192,606 		JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B1 multiple interactions ISO Sulindac analog binds to and results in decreased activity of AKR1B1 protein; Sulindac binds to and results in decreased activity of AKR1B1 protein CTD PMID:25532697 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157 		JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 multiple interactions ISO Sulindac analog binds to and results in decreased activity of AKR1B10 protein; Sulindac binds to and results in decreased activity of AKR1B10 protein CTD PMID:25532697 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852 		JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 decreases activity ISO Sulindac results in decreased activity of AKR1C1 protein CTD PMID:19010312 NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326 		JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 decreases activity ISO Sulindac results in decreased activity of AKR1C2 protein CTD PMID:19010312 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity ISO Sulindac results in decreased activity of AKR1C3 protein CTD PMID:19010312 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation		 ISO
EXP		 [AKT1 protein affects the reaction [Sulindac analog results in decreased expression of HIF1A protein]] which affects the susceptibility to Oxygen; AKT1 protein affects the reaction [Sulindac analog results in decreased expression of HIF1A protein]
[Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of AKT1 mRNA
Sulindac analog results in decreased phosphorylation of AKT1 protein		 CTD PMID:18924134 PMID:20371263 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Akt1s1 AKT1 substrate 1 decreases expression EXP Sulindac results in decreased expression of AKT1S1 mRNA CTD PMID:24136188 NCBI chr 1:95,333,186...95,339,678
Ensembl chr 1:95,332,898...95,339,677 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 decreases expression
increases expression		 ISO
EXP		 Sulindac results in decreased expression of AKT2 mRNA
Sulindac results in increased expression of AKT2 mRNA		 CTD PMID:11906190 PMID:24136188 NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817 		JBrowse link
G Alb albumin multiple interactions EXP [Sulindac co-treated with REN2] results in increased expression of ALB protein CTD PMID:12586211 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of ALDH1A1 mRNA CTD PMID:20371263 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961 		JBrowse link
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of ALDH1L1 mRNA CTD PMID:20371263 NCBI chr 4:123,059,989...123,106,471
Ensembl chr 4:123,060,008...123,106,465 		JBrowse link
G Aldh3a2 aldehyde dehydrogenase 3 family, member A2 decreases expression EXP Sulindac results in decreased expression of ALDH3A2 mRNA CTD PMID:24136188 NCBI chr10:45,928,313...45,949,366
Ensembl chr10:45,908,524...45,949,281 		JBrowse link
G Aldh6a1 aldehyde dehydrogenase 6 family, member A1 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of ALDH6A1 mRNA CTD PMID:20371263 NCBI chr 6:104,077,975...104,098,636
Ensembl chr 6:104,077,979...104,098,656 		JBrowse link
G Alg14 ALG14, UDP-N-acetylglucosaminyltransferase subunit increases expression EXP Sulindac results in increased expression of ALG14 mRNA CTD PMID:24136188 NCBI chr 2:209,368,285...209,445,425
Ensembl chr 2:209,368,312...209,445,431 		JBrowse link
G Alox15 arachidonate 15-lipoxygenase increases expression
multiple interactions
increases activity		 ISO Sulindac results in increased expression of ALOX15 protein
[Sulindac results in increased expression of ALOX15 protein] which results in increased chemical synthesis of 13-hydroxy-9,11-octadecadienoic acid
Sulindac results in increased activity of ALOX15 protein		 CTD PMID:10904086 PMID:11406566 NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874 		JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions ISO Sulindac promotes the reaction [cobaltous chloride results in decreased expression of ALPL protein]; Sulindac promotes the reaction [Deferoxamine results in decreased expression of ALPL protein] CTD PMID:21882223 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446 		JBrowse link
G Amd1 adenosylmethionine decarboxylase 1 multiple interactions ISO [Sulindac co-treated with Putrescine] results in decreased activity of AMD1 protein CTD PMID:17474863 NCBI chr20:43,695,783...43,711,476
Ensembl chr20:43,697,237...43,711,476 		JBrowse link
G Amt aminomethyltransferase increases expression EXP Sulindac results in increased expression of AMT mRNA CTD PMID:24136188 NCBI chr 8:108,981,620...108,988,127
Ensembl chr 8:108,976,472...108,988,126 		JBrowse link
G Amz2 archaelysin family metallopeptidase 2 decreases expression EXP Sulindac results in decreased expression of AMZ2 mRNA CTD PMID:24136188 NCBI chr10:94,401,546...94,412,116
Ensembl chr10:94,401,579...94,412,114 		JBrowse link
G Angptl3 angiopoietin-like 3 decreases expression ISO Sulindac results in decreased expression of ANGPTL3 mRNA CTD PMID:32535746 NCBI chr 5:113,703,007...113,710,044
Ensembl chr 5:113,703,012...113,709,957 		JBrowse link
G Ankrd11 ankyrin repeat domain containing 11 increases expression ISO Sulindac results in increased expression of ANKRD11 mRNA CTD PMID:11906190 NCBI chr19:50,940,284...51,098,962
Ensembl chr19:50,940,299...51,098,962 		JBrowse link
G Ankrd24 ankyrin repeat domain 24 increases expression EXP Sulindac results in increased expression of ANKRD24 mRNA CTD PMID:24136188 NCBI chr 7:8,061,634...8,081,142
Ensembl chr 7:8,061,953...8,081,142 		JBrowse link
G Ankrd28 ankyrin repeat domain 28 decreases expression EXP Sulindac results in decreased expression of ANKRD28 mRNA CTD PMID:24136188 NCBI chr16:6,918,487...7,050,244
Ensembl chr16:6,914,336...7,050,249 		JBrowse link
G Ap1ar adaptor-related protein complex 1 associated regulatory protein increases expression EXP Sulindac results in increased expression of AP1AR mRNA CTD PMID:24136188 NCBI chr 2:216,276,631...216,309,020
Ensembl chr 2:216,276,631...216,309,013 		JBrowse link
G Ap3d1 adaptor related protein complex 3 subunit delta 1 increases expression EXP Sulindac results in increased expression of AP3D1 mRNA CTD PMID:24136188 NCBI chr 7:8,970,249...9,005,651
Ensembl chr 7:8,970,291...9,005,643 		JBrowse link
G Apc APC regulator of WNT signaling pathway multiple interactions
increases expression		 EXP Sulindac inhibits the reaction [Azoxymethane results in decreased expression of APC mRNA]
Sulindac results in increased expression of APC protein		 CTD PMID:11076880 PMID:12458338 NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696 		JBrowse link
G Apob apolipoprotein B decreases secretion ISO Sulindac results in decreased secretion of APOB protein CTD PMID:32535746 NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497 		JBrowse link
G Apoc3 apolipoprotein C3 decreases secretion ISO Sulindac results in decreased secretion of APOC3 protein CTD PMID:32535746 NCBI chr 8:46,531,478...46,533,658
Ensembl chr 8:46,531,478...46,533,583 		JBrowse link
G App amyloid beta precursor protein multiple interactions ISO Sulindac inhibits the reaction [CDKN1A protein results in increased expression of APP mRNA] CTD PMID:15190207 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Aqp1 aquaporin 1 decreases expression EXP Sulindac results in decreased expression of AQP1 mRNA CTD PMID:24136188 NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690 		JBrowse link
G Arglu1 arginine and glutamate rich 1 increases expression ISO Sulindac results in increased expression of ARGLU1 mRNA CTD PMID:11906190 NCBI chr16:80,753,300...80,777,350
Ensembl chr16:80,753,315...80,777,349 		JBrowse link
G Arid1b AT-rich interaction domain 1B decreases expression EXP Sulindac results in decreased expression of ARID1B mRNA CTD PMID:24136188 NCBI chr 1:45,567,991...45,923,644
Ensembl chr 1:45,563,623...45,923,493 		JBrowse link
G Arl1 ADP-ribosylation factor like GTPase 1 increases expression EXP Sulindac results in increased expression of ARL1 mRNA CTD PMID:24136188 NCBI chr 7:23,120,004...23,131,173
Ensembl chr 7:23,119,589...23,131,898 		JBrowse link
G Arrdc3 arrestin domain containing 3 increases expression ISO Sulindac results in increased expression of ARRDC3 mRNA CTD PMID:11906190 NCBI chr 2:11,137,464...11,149,978
Ensembl chr 2:11,137,460...11,149,978 		JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO Sulindac results in increased expression of ASNS mRNA CTD PMID:11906190 NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423 		JBrowse link
G Asnsd1 asparagine synthetase domain containing 1 increases expression EXP Sulindac results in increased expression of ASNSD1 mRNA CTD PMID:24136188 NCBI chr 9:48,126,808...48,139,073
Ensembl chr 9:48,126,808...48,139,073 		JBrowse link
G Ate1 arginyltransferase 1 decreases expression EXP Sulindac results in decreased expression of ATE1 mRNA CTD PMID:24136188 NCBI chr 1:184,961,548...185,081,112
Ensembl chr 1:184,963,562...185,080,908 		JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Sulindac results in increased expression of ATF3 mRNA CTD PMID:11906190 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631 		JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO Sulindac results in increased expression of ATF4 mRNA CTD PMID:11906190 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Atf6 activating transcription factor 6 increases expression ISO Sulindac results in increased expression of ATF6 mRNA CTD PMID:32535746 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177 		JBrowse link
G Atg3 autophagy related 3 increases expression EXP Sulindac results in increased expression of ATG3 mRNA CTD PMID:24136188 NCBI chr11:55,624,914...55,653,249
Ensembl chr11:55,624,917...55,653,224 		JBrowse link
G Atp2a1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 decreases expression ISO Sulindac results in decreased expression of ATP2A1 mRNA CTD PMID:11906190 NCBI chr 1:181,026,606...181,044,859
Ensembl chr 1:181,026,608...181,044,838 		JBrowse link
G Atp6v1a ATPase H+ transporting V1 subunit A increases expression EXP Sulindac results in increased expression of ATP6V1A mRNA CTD PMID:24136188 NCBI chr11:56,561,444...56,614,694
Ensembl chr11:56,560,974...56,614,694 		JBrowse link
G Atp6v1e1 ATPase H+ transporting V1 subunit E1 increases expression EXP Sulindac results in increased expression of ATP6V1E1 mRNA CTD PMID:24136188 NCBI chr 4:154,022,358...154,044,486
Ensembl chr 4:154,022,358...154,044,584 		JBrowse link
G Auh AU RNA binding methylglutaconyl-CoA hydratase multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of AUH mRNA CTD PMID:20371263 NCBI chr17:12,329,522...12,424,882
Ensembl chr17:12,329,524...12,424,896 		JBrowse link
G Aurka aurora kinase A decreases expression ISO Sulindac results in decreased expression of AURKA mRNA CTD PMID:11906190 NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390 		JBrowse link
G Aurkaip1 aurora kinase A interacting protein 1 decreases expression EXP Sulindac results in decreased expression of AURKAIP1 mRNA CTD PMID:24136188 NCBI chr 5:166,435,177...166,436,888
Ensembl chr 5:166,417,508...166,436,882 		JBrowse link
G B4galt1 beta-1,4-galactosyltransferase 1 decreases expression EXP Sulindac results in decreased expression of B4GALT1 mRNA CTD PMID:24136188 NCBI chr 5:55,935,614...55,982,461
Ensembl chr 5:55,935,615...55,982,461 		JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions
decreases expression		 ISO Sulindac inhibits the reaction [EGF protein results in increased phosphorylation of BAD protein]
Sulindac results in decreased expression of BAD protein		 CTD PMID:12566304 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions
affects localization		 ISO SB 203580 inhibits the reaction [Sulindac affects the localization of BAK1 protein] CTD PMID:17136320 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
affects localization
increases response to substance		 ISO SB 203580 inhibits the reaction [Sulindac affects the localization of BAX protein]
Sulindac results in increased expression of BAX protein
BAX protein results in increased susceptibility to Sulindac		 CTD PMID:11062132 PMID:17136320 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression ISO Sulindac results in increased expression of BBC3 mRNA CTD PMID:11906190 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Bcap29 B-cell receptor-associated protein 29 increases expression ISO Sulindac results in increased expression of BCAP29 mRNA CTD PMID:11906190 NCBI chr 6:48,182,702...48,222,698
Ensembl chr 6:48,182,706...48,222,720 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 ISO
EXP		 Sulindac results in decreased expression of BCL2 protein
[Olive Oil co-treated with Sulindac] results in decreased expression of BCL2 protein
[Sulindac results in increased abundance of Reactive Oxygen Species] which results in increased cleavage of BCL2 protein		 CTD PMID:10223192 PMID:15309441 PMID:15793875 PMID:17136320 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
decreases expression		 ISO [Sulindac co-treated with arsenic trioxide] results in increased phosphorylation of BCL2L1 protein; Acetylcysteine inhibits the reaction [[Sulindac co-treated with arsenic trioxide] results in increased phosphorylation of BCL2L1 protein]; MAPK8 affects the reaction [[Sulindac co-treated with arsenic trioxide] results in increased phosphorylation of BCL2L1 protein]; pyrazolanthrone inhibits the reaction [[Sulindac co-treated with arsenic trioxide] results in increased phosphorylation of BCL2L1 protein]
Sulindac results in decreased expression of BCL2L1 protein		 CTD PMID:11062132 PMID:18281123 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 multiple interactions ISO [Sulindac results in increased abundance of Reactive Oxygen Species] which results in decreased expression of BIRC2 protein CTD PMID:17136320 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions ISO [Sulindac results in increased abundance of Reactive Oxygen Species] which results in decreased expression of BIRC3 protein CTD PMID:17136320 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
decreases expression		 ISO [Sulindac co-treated with Arsenic Trioxide] results in decreased expression of BIRC5 protein; [Sulindac co-treated with Vorinostat] results in decreased expression of BIRC5 mRNA; [Sulindac co-treated with Vorinostat] results in decreased expression of BIRC5 protein; [Sulindac results in increased abundance of Reactive Oxygen Species] which results in decreased expression of BIRC5 protein; BIRC5 protein inhibits the reaction [Sulindac results in decreased expression of STAT3 protein modified form]; BIRC5 protein inhibits the reaction [Sulindac results in decreased expression of STAT3 protein]
Sulindac results in decreased expression of BIRC5 mRNA; Sulindac results in decreased expression of BIRC5 protein		 CTD PMID:11906190 PMID:14610217 PMID:17136320 PMID:17401459 PMID:18156316 More... NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Blmh bleomycin hydrolase increases expression EXP Sulindac results in increased expression of BLMH mRNA CTD PMID:24136188 NCBI chr10:61,772,112...61,815,212
Ensembl chr10:61,758,478...61,815,212 		JBrowse link
G Bnip3l BCL2 interacting protein 3 like increases expression EXP Sulindac results in increased expression of BNIP3L mRNA CTD PMID:24136188 NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803 		JBrowse link
G Borcs7 BLOC-1 related complex subunit 7 increases expression EXP Sulindac results in increased expression of BORCS7 mRNA CTD PMID:24136188 NCBI chr 1:245,564,347...245,578,182
Ensembl chr 1:245,564,369...245,579,343 		JBrowse link
G Brca1 BRCA1, DNA repair associated decreases expression ISO Sulindac results in decreased expression of BRCA1 mRNA CTD PMID:16273229 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304 		JBrowse link
G Brd4 bromodomain containing 4 decreases expression ISO Sulindac results in decreased expression of BRD4 mRNA CTD PMID:11906190 NCBI chr 7:11,216,446...11,296,029
Ensembl chr 7:11,216,446...11,295,539 		JBrowse link
G Btbd1 BTB domain containing 1 increases expression EXP Sulindac results in increased expression of BTBD1 mRNA CTD PMID:24136188 NCBI chr 1:135,734,549...135,773,067
Ensembl chr 1:135,734,589...135,771,981 		JBrowse link
G Bzw1 basic leucine zipper and W2 domains 1 increases expression EXP Sulindac results in increased expression of BZW1 mRNA CTD PMID:24136188 NCBI chr 9:59,930,672...59,944,468
Ensembl chr 9:59,930,744...59,944,430 		JBrowse link
G Bzw2 basic leucine zipper and W2 domains 2 decreases expression ISO Sulindac results in decreased expression of BZW2 mRNA CTD PMID:11093808 NCBI chr 6:52,828,069...52,888,599
Ensembl chr 6:52,827,661...52,888,628 		JBrowse link
G C17h7orf25 similar to human chromosome 7 open reading frame 25 decreases expression EXP Sulindac results in decreased expression of C17H7ORF25 mRNA CTD PMID:24136188 NCBI chr17:50,543,231...50,549,880
Ensembl chr17:50,542,858...50,549,976 		JBrowse link
G C18h18orf32 similar to human chromosome 18 open reading frame 32 decreases expression EXP Sulindac results in decreased expression of C18H18ORF32 mRNA CTD PMID:24136188 NCBI chr18:68,586,278...68,594,851
Ensembl chr18:68,586,211...68,596,787 		JBrowse link
G C1galt1c1 C1GALT1-specific chaperone 1 decreases expression EXP Sulindac results in decreased expression of C1GALT1C1 mRNA CTD PMID:24136188 NCBI chr  X:117,378,123...117,382,620
Ensembl chr  X:117,375,525...117,382,787 		JBrowse link
G C2h1orf52 similar to human chromosome 1 open reading frame 52 increases expression ISO Sulindac results in increased expression of C1ORF52 mRNA CTD PMID:11906190 NCBI chr 2:234,853,378...234,860,045
Ensembl chr 2:234,853,410...234,860,040 		JBrowse link
G C4b complement C4B decreases expression EXP Sulindac results in decreased expression of C4B mRNA CTD PMID:24136188 NCBI chr20:4,197,371...4,211,684
Ensembl chr20:4,197,366...4,211,681 		JBrowse link
G Calm3 calmodulin 3 decreases expression
increases expression		 ISO
EXP		 Sulindac results in decreased expression of CALM3 mRNA
Sulindac results in increased expression of CALM3 mRNA		 CTD PMID:11906190 PMID:24136188 NCBI chr 1:77,590,668...77,597,776
Ensembl chr 1:77,589,230...77,592,207 		JBrowse link
G Car9 carbonic anhydrase 9 decreases expression ISO Sulindac analog results in decreased expression of CA9 mRNA CTD PMID:18924134 NCBI chr 5:57,763,234...57,769,838
Ensembl chr 5:57,763,206...57,769,838 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases expression		 ISO
EXP		 [Sulindac co-treated with arsenic trioxide] results in increased activity of CASP3 protein; Acetylcysteine inhibits the reaction [[Sulindac co-treated with arsenic trioxide] results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [[Sulindac co-treated with arsenic trioxide] results in increased activity of CASP3 protein]
epigallocatechin gallate promotes the reaction [Sulindac inhibits the reaction [1,2-Dimethylhydrazine results in decreased expression of CASP3 protein]]; kaempferol promotes the reaction [Sulindac inhibits the reaction [1,2-Dimethylhydrazine results in decreased expression of CASP3 protein]]; Sulindac inhibits the reaction [1,2-Dimethylhydrazine results in decreased expression of CASP3 protein]
Sulindac results in increased activity of CASP3 protein
[Sulindac results in increased expression of IL24 protein] which results in increased expression of CASP3 protein		 CTD PMID:12017300 PMID:15713900 PMID:15946692 PMID:18281123 PMID:29999212 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO [Sulindac co-treated with TNFSF10 protein] results in increased activity of CASP8 protein CTD PMID:21171083 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression
increases activity		 ISO [Sulindac co-treated with arsenic trioxide] results in increased activity of CASP9 protein
[Sulindac results in increased expression of IL24 protein] which results in increased expression of CASP9 protein
Sulindac results in increased activity of CASP9 protein		 CTD PMID:15713900 PMID:18281123 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cast calpastatin decreases expression EXP Sulindac results in decreased expression of CAST mRNA CTD PMID:24136188 NCBI chr 2:3,973,112...4,082,658
Ensembl chr 2:3,973,112...4,082,659 		JBrowse link
G Cavin3 caveolae associated protein 3 increases expression ISO Sulindac results in increased expression of CAVIN3 mRNA CTD PMID:11906190 NCBI chr 1:159,826,549...159,828,138
Ensembl chr 1:159,826,549...159,828,161 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Sulindac inhibits the reaction [IL1B protein results in increased expression of CCL5 mRNA]; Sulindac inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA] CTD PMID:16159934 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Ccna2 cyclin A2 decreases expression ISO Sulindac results in decreased expression of CCNA2 protein CTD PMID:16488075 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO Sulindac results in decreased expression of CCNB1 mRNA CTD PMID:11906190 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression		 ISO CTNNB1 protein affects the reaction [Sulindac results in decreased expression of CCND1 protein]; Sulindac inhibits the reaction [TNF protein results in increased expression of CCND1 protein]
[Sulindac co-treated with Plant Extracts] results in decreased expression of CCND1 protein		 CTD PMID:11504793 PMID:11593435 PMID:12351151 PMID:12584176 PMID:15020200 More... NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccne1 cyclin E1 decreases expression ISO Sulindac results in decreased expression of CCNE1 protein CTD PMID:16488075 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Ccnj cyclin J decreases expression ISO Sulindac results in decreased expression of CCNJ mRNA CTD PMID:11906190 NCBI chr 1:239,659,588...239,677,367 JBrowse link
G Ccnq cyclin Q decreases expression EXP Sulindac results in decreased expression of CCNQ mRNA CTD PMID:24136188 NCBI chr10:63,646,532...63,647,695
Ensembl chr10:63,646,527...63,647,961 		JBrowse link
G Cct4 chaperonin containing TCP1 subunit 4 decreases expression EXP Sulindac results in decreased expression of CCT4 mRNA CTD PMID:24136188 NCBI chr14:96,991,853...97,004,732
Ensembl chr14:96,991,859...97,005,267 		JBrowse link
G Ccz1 CCZ1 homolog, vacuolar protein trafficking and biogenesis associated increases expression EXP Sulindac results in increased expression of CCZ1B mRNA CTD PMID:24136188 NCBI chr12:10,601,066...10,624,608
Ensembl chr12:10,601,056...10,624,608 		JBrowse link
G Cdc37l1 cell division cycle 37-like 1 decreases expression EXP Sulindac results in decreased expression of CDC37L1 mRNA CTD PMID:24136188 NCBI chr 1:226,705,019...226,733,994
Ensembl chr 1:226,705,003...226,761,175 		JBrowse link
G Cdc42ep1 CDC42 effector protein 1 increases expression ISO Sulindac results in increased expression of CDC42EP1 mRNA CTD PMID:11906190 NCBI chr 7:110,395,287...110,403,203
Ensembl chr 7:110,395,332...110,403,200 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO Sulindac results in decreased expression of CDK1 mRNA CTD PMID:16273229 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions
decreases activity		 ISO Sulindac promotes the reaction [CDKN1A protein results in decreased activity of CDK2 protein]
Sulindac results in decreased activity of CDK2 protein		 CTD PMID:14566837 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions
decreases expression		 ISO
EXP		 CTNNB1 protein affects the reaction [Sulindac results in decreased expression of CDK4 protein]
[Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of CDK4 mRNA		 CTD PMID:17292881 PMID:18291362 PMID:20371263 NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases expression ISO Sulindac results in decreased expression of CDK6 protein CTD PMID:16488075 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
increases response to substance
increases activity
decreases activity		 ISO
EXP		 [Sulindac co-treated with epigallocatechin gallate] results in increased expression of CDKN1A mRNA; CDKN1A protein promotes the reaction [Sulindac results in increased expression of and results in increased phosphorylation of MAPK8 protein]; CSK protein affects the reaction [Sulindac results in increased expression of CDKN1A protein]; Sulindac inhibits the reaction [CDKN1A protein results in increased expression of APP mRNA]; Sulindac inhibits the reaction [CDKN1A protein results in increased expression of CTSB mRNA]; Sulindac inhibits the reaction [CDKN1A protein results in increased expression of GBA1 mRNA]; Sulindac inhibits the reaction [CDKN1A protein results in increased expression of GRN mRNA]; Sulindac inhibits the reaction [CDKN1A protein results in increased expression of IL32 mRNA]; Sulindac inhibits the reaction [CDKN1A protein results in increased expression of ITGB3 mRNA]; Sulindac inhibits the reaction [CDKN1A protein results in increased expression of LGALS3 mRNA]; Sulindac inhibits the reaction [CDKN1A protein results in increased expression of LGALS3BP mRNA]; Sulindac inhibits the reaction [CDKN1A protein results in increased expression of SAA1 mRNA]; Sulindac inhibits the reaction [CDKN1A protein results in increased expression of SHC1 mRNA]; Sulindac inhibits the reaction [CDKN1A protein results in increased expression of SOD2 mRNA]; Sulindac inhibits the reaction [CDKN1A protein results in increased expression of TGM2 mRNA]; Sulindac promotes the reaction [CDKN1A protein results in decreased activity of CDK2 protein]
Sulindac results in increased expression of CDKN1A mRNA; Sulindac results in increased expression of CDKN1A protein
[Azoxymethane co-treated with Sulindac] results in increased expression of CDKN1A protein
CDKN1A protein results in increased susceptibility to Sulindac
Sulindac results in increased activity of CDKN1A protein
Sulindac results in decreased activity of CDKN1A protein		 CTD PMID:11507085 PMID:12628509 PMID:14566837 PMID:15190207 PMID:15688007 More... NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions EXP Sulindac inhibits the reaction [Azoxymethane results in decreased expression of CDKN1B protein] CTD PMID:12189186 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A multiple interactions EXP Sulindac inhibits the reaction [Azoxymethane results in decreased expression of CDKN2A mRNA] CTD PMID:12189186 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Cep15 centrosomal protein 15 decreases expression EXP Sulindac results in decreased expression of CEP15 mRNA CTD PMID:24136188 NCBI chr15:12,815,159...12,835,115
Ensembl chr15:12,818,385...12,833,838 		JBrowse link
G Cfl2 cofilin 2 decreases expression EXP Sulindac results in decreased expression of CFL2 mRNA CTD PMID:24136188 NCBI chr 6:72,355,664...72,359,709
Ensembl chr 6:72,355,664...72,359,674 		JBrowse link
G Chchd3 coiled-coil-helix-coiled-coil-helix domain containing 3 decreases expression EXP Sulindac results in decreased expression of CHCHD3 mRNA CTD PMID:24136188 NCBI chr 4:61,360,352...61,616,850
Ensembl chr 4:61,360,353...61,616,847 		JBrowse link
G Chchd5 coiled-coil-helix-coiled-coil-helix domain containing 5 increases expression EXP Sulindac results in increased expression of CHCHD5 mRNA CTD PMID:24136188 NCBI chr 3:116,361,845...116,372,238
Ensembl chr 3:116,361,885...116,367,169 		JBrowse link
G Chd8 chromodomain helicase DNA binding protein 8 decreases expression EXP Sulindac results in decreased expression of CHD8 mRNA CTD PMID:24136188 NCBI chr15:24,905,789...24,965,461
Ensembl chr15:24,905,789...24,951,285 		JBrowse link
G Chmp2a charged multivesicular body protein 2A decreases expression EXP Sulindac results in decreased expression of CHMP2A mRNA CTD PMID:24136188 NCBI chr 1:73,660,045...73,662,894
Ensembl chr 1:73,660,046...73,662,452 		JBrowse link
G Chrac1 chromatin accessibility complex subunit 1 increases expression EXP Sulindac results in increased expression of CHRAC1 mRNA CTD PMID:24136188 NCBI chr 7:105,013,047...105,016,435
Ensembl chr 7:105,013,015...105,017,136 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO Sulindac inhibits the reaction [TNF protein results in increased activity of CHUK protein] CTD PMID:15489888 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065 		JBrowse link
G Clpp caseinolytic mitochondrial matrix peptidase proteolytic subunit increases expression EXP Sulindac results in increased expression of CLPP mRNA CTD PMID:24136188 NCBI chr 9:1,831,680...1,837,700
Ensembl chr 9:1,830,311...1,837,693 		JBrowse link
G Clu clusterin affects expression ISO Sulindac affects the expression of CLU protein CTD PMID:12388792 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Cmtm6 CKLF-like MARVEL transmembrane domain containing 6 increases expression EXP Sulindac results in increased expression of CMTM6 mRNA CTD PMID:24136188 NCBI chr 8:114,422,934...114,441,034
Ensembl chr 8:114,422,921...114,441,033 		JBrowse link
G Cngb1 cyclic nucleotide gated channel subunit beta 1 decreases expression EXP Sulindac results in decreased expression of CNGB1 mRNA CTD PMID:24136188 NCBI chr19:9,726,595...9,791,111
Ensembl chr19:9,726,595...9,791,173 		JBrowse link
G Cnnm4 cyclin and CBS domain divalent metal cation transport mediator 4 increases expression ISO Sulindac results in increased expression of CNNM4 mRNA CTD PMID:11906190 NCBI chr 9:38,711,726...38,750,942
Ensembl chr 9:38,711,710...38,750,942 		JBrowse link
G Cnot6 CCR4-NOT transcription complex, subunit 6 decreases expression EXP Sulindac results in decreased expression of CNOT6 mRNA CTD PMID:24136188 NCBI chr10:33,978,785...34,031,025
Ensembl chr10:33,980,831...34,031,025 		JBrowse link
G Col1a2 collagen type I alpha 2 chain increases expression ISO Sulindac results in increased expression of COL1A2 mRNA CTD PMID:18499699 NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867 		JBrowse link
G Col5a2 collagen type V alpha 2 chain increases expression ISO Sulindac results in increased expression of COL5A2 mRNA CTD PMID:18499699 NCBI chr 9:47,448,741...47,598,134
Ensembl chr 9:47,448,736...47,598,154 		JBrowse link
G Col6a2 collagen type VI alpha 2 chain increases expression ISO Sulindac results in increased expression of COL6A2 mRNA CTD PMID:18499699 NCBI chr20:12,021,676...12,049,425
Ensembl chr20:12,021,767...12,057,564 		JBrowse link
G Col6a3 collagen type VI alpha 3 chain increases expression ISO Sulindac results in increased expression of COL6A3 mRNA CTD PMID:18499699 NCBI chr 9:91,361,578...91,439,434
Ensembl chr 9:91,361,583...91,439,471 		JBrowse link
G Commd3 COMM domain containing 3 increases expression EXP Sulindac results in increased expression of COMMD3 mRNA CTD PMID:24136188 NCBI chr17:81,327,444...81,331,191
Ensembl chr17:81,327,405...81,331,177 		JBrowse link
G Commd5 COMM domain containing 5 increases expression EXP Sulindac results in increased expression of COMMD5 mRNA CTD PMID:24136188 NCBI chr 7:108,621,766...108,623,616
Ensembl chr 7:108,598,673...108,624,764 		JBrowse link
G Cops7a COP9 signalosome subunit 7A increases expression EXP Sulindac results in increased expression of COPS7A mRNA CTD PMID:24136188 NCBI chr 4:157,766,626...157,792,632
Ensembl chr 4:157,766,588...157,773,948 		JBrowse link
G Cox15 cytochrome c oxidase assembly homolog COX15 increases expression EXP Sulindac results in increased expression of COX15 mRNA CTD PMID:24136188 NCBI chr 1:242,605,588...242,622,279
Ensembl chr 1:242,605,588...242,622,261 		JBrowse link
G Cpne1 copine 1 decreases expression ISO Sulindac results in decreased expression of CPNE1 mRNA CTD PMID:11906190 NCBI chr 3:144,587,531...144,629,911
Ensembl chr 3:144,588,995...144,598,636 		JBrowse link
G Cpsf3 cleavage and polyadenylation specific factor 3 increases expression EXP Sulindac results in increased expression of CPSF3 mRNA CTD PMID:24136188 NCBI chr 6:40,836,121...40,864,129
Ensembl chr 6:40,836,097...40,864,128 		JBrowse link
G Creb3l3 cAMP responsive element binding protein 3-like 3 increases expression EXP Sulindac results in increased expression of CREB3L3 mRNA CTD PMID:24136188 NCBI chr 7:8,622,614...8,631,053
Ensembl chr 7:8,622,614...8,631,048 		JBrowse link
G Crebzf CREB/ATF bZIP transcription factor increases expression EXP Sulindac results in increased expression of CREBZF mRNA CTD PMID:24136188 NCBI chr 1:144,416,864...144,423,540
Ensembl chr 1:144,417,446...144,428,553 		JBrowse link
G Cry2 cryptochrome circadian regulator 2 decreases expression EXP Sulindac results in decreased expression of CRY2 mRNA CTD PMID:24136188 NCBI chr 3:78,374,995...78,405,001
Ensembl chr 3:78,374,995...78,404,965 		JBrowse link
G Csf1 colony stimulating factor 1 decreases expression EXP Sulindac results in decreased expression of CSF1 mRNA CTD PMID:24136188 NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704 		JBrowse link
G Csk C-terminal Src kinase multiple interactions ISO
EXP		 CSK protein affects the reaction [Sulindac results in increased expression of CDKN1A protein]
[[Azoxymethane co-treated with Sulindac] results in increased expression of CSK protein] which results in increased phosphorylation of and results in decreased activity of SRC protein; [Azoxymethane co-treated with Sulindac] results in increased expression of CSK protein		 CTD PMID:18644992 NCBI chr 8:58,029,748...58,048,742
Ensembl chr 8:58,029,749...58,048,292 		JBrowse link
G Csnk2a1 casein kinase 2 alpha 1 decreases expression
increases expression		 ISO
EXP		 Sulindac results in decreased expression of CSNK2A1 mRNA
Sulindac results in increased expression of CSNK2A1 mRNA		 CTD PMID:11906190 PMID:24136188 NCBI chr 3:140,709,984...140,756,757
Ensembl chr 3:140,709,991...140,756,696 		JBrowse link
G Csnk2a2 casein kinase 2 alpha 2 increases expression ISO Sulindac results in increased expression of CSNK2A2 mRNA CTD PMID:11906190 NCBI chr19:9,556,443...9,596,080
Ensembl chr19:9,556,260...9,596,080 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
decreases expression		 ISO
EXP		 CTNNB1 protein affects the reaction [Sulindac results in decreased expression of CCND1 protein]; CTNNB1 protein affects the reaction [Sulindac results in decreased expression of CDK4 protein]; CTNNB1 protein affects the reaction [Sulindac results in decreased expression of MYC protein]; Sulindac results in decreased activity of [LEF1 protein binds to CTNNB1 protein]
epigallocatechin gallate promotes the reaction [Sulindac inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CTNNB1 protein]]; kaempferol promotes the reaction [Sulindac inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CTNNB1 protein]]; Sulindac inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CTNNB1 protein]
Sulindac results in decreased expression of CTNNB1 protein
[Sulindac co-treated with Plant Extracts] results in decreased expression of CTNNB1 protein		 CTD PMID:10223192 PMID:11751639 PMID:12351151 PMID:18291362 PMID:29999212 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Ctsb cathepsin B multiple interactions ISO Sulindac inhibits the reaction [CDKN1A protein results in increased expression of CTSB mRNA] CTD PMID:15190207 NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500 		JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 multiple interactions ISO Sulindac inhibits the reaction [IFNG protein results in increased expression of CXCL9 mRNA] CTD PMID:17010317 NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
decreases activity
increases activity		 ISO
EXP		 Sulindac results in increased expression of CYP1A1 mRNA
Sulindac results in decreased activity of CYP1A1 protein
Sulindac results in increased activity of CYP1A1 protein		 CTD PMID:16531450 PMID:17985343 PMID:33814510 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
decreases expression		 ISO
EXP		 Sulindac results in increased expression of CYP1A2 mRNA
Sulindac results in decreased expression of CYP1A2 mRNA		 CTD PMID:16531450 PMID:17985343 PMID:24136188 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression
decreases activity
increases activity		 ISO
EXP		 Sulindac results in increased expression of CYP1B1 mRNA
Sulindac results in decreased activity of CYP1B1 protein
Sulindac results in increased activity of CYP1B1 protein		 CTD PMID:16531450 PMID:17985343 PMID:33814510 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of CYP2D4 mRNA CTD PMID:20371263 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of CYP2J4 mRNA CTD PMID:20371263 NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794 		JBrowse link
G Cyp4b1 cytochrome P450, family 4, subfamily b, polypeptide 1 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of CYP4B1 mRNA CTD PMID:20371263 NCBI chr 5:129,139,019...129,176,860
Ensembl chr 5:129,139,038...129,156,348 		JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of CYP8B1 mRNA CTD PMID:20371263 NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166 		JBrowse link
G Dcn decorin decreases expression ISO Sulindac results in decreased expression of DCN mRNA CTD PMID:11507085 NCBI chr 7:32,281,252...32,321,291
Ensembl chr 7:32,281,252...32,321,270 		JBrowse link
G Dctn5 dynactin subunit 5 decreases expression EXP Sulindac results in decreased expression of DCTN5 mRNA CTD PMID:24136188 NCBI chr 1:176,689,176...176,705,907
Ensembl chr 1:176,689,156...176,705,906 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression		 ISO [Sulindac co-treated with epigallocatechin gallate] results in increased expression of DDIT3 mRNA
Sulindac results in increased expression of DDIT3 mRNA		 CTD PMID:12628509 PMID:24136188 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Ddx1 DEAD-box helicase 1 decreases expression EXP Sulindac results in decreased expression of DDX1 mRNA CTD PMID:24136188 NCBI chr 6:35,996,469...36,027,340
Ensembl chr 6:35,996,469...36,027,365 		JBrowse link
G Degs1 delta(4)-desaturase, sphingolipid 1 increases expression EXP Sulindac results in increased expression of DEGS1 mRNA CTD PMID:24136188 NCBI chr13:93,946,154...93,953,677
Ensembl chr13:93,946,157...93,953,664 		JBrowse link
G Dffb DNA fragmentation factor subunit beta affects localization ISO Sulindac affects the localization of DFFB protein CTD PMID:15946692 NCBI chr 5:164,522,446...164,534,733
Ensembl chr 5:164,522,463...164,534,628 		JBrowse link
G Dhrs11 dehydrogenase/reductase 11 decreases activity ISO Sulindac results in decreased activity of DHRS11 protein CTD PMID:30926317 NCBI chr10:69,698,214...69,708,294
Ensembl chr10:69,698,214...69,708,295 		JBrowse link
G Dhx36 DEAH-box helicase 36 increases expression EXP Sulindac results in increased expression of DHX36 mRNA CTD PMID:24136188 NCBI chr 2:146,856,469...146,894,577
Ensembl chr 2:146,856,469...146,894,572 		JBrowse link
G Dip2c disco-interacting protein 2 homolog C increases expression EXP Sulindac results in increased expression of DIP2C mRNA CTD PMID:24136188 NCBI chr17:60,647,346...61,032,467
Ensembl chr17:60,649,065...61,032,305 		JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 increases expression EXP Sulindac results in increased expression of DLG1 mRNA CTD PMID:24136188 NCBI chr11:68,911,883...69,103,230
Ensembl chr11:68,911,883...69,102,689 		JBrowse link
G Dnajc10 DnaJ heat shock protein family (Hsp40) member C10 increases expression EXP Sulindac results in increased expression of DNAJC10 mRNA CTD PMID:24136188 NCBI chr 3:65,232,031...65,272,732
Ensembl chr 3:65,232,697...65,272,719 		JBrowse link
G Dnajc15 DnaJ heat shock protein family (Hsp40) member C15 increases expression EXP Sulindac results in increased expression of DNAJC15 mRNA CTD PMID:24136188 NCBI chr15:53,182,060...53,249,675
Ensembl chr15:53,184,855...53,249,675 		JBrowse link
G Dpys dihydropyrimidinase increases expression ISO Sulindac results in increased expression of DPYS mRNA CTD PMID:11906190 NCBI chr 7:70,822,648...70,929,255
Ensembl chr 7:70,835,789...70,929,231 		JBrowse link
G Dynll1 dynein light chain LC8-type 1 decreases expression EXP Sulindac results in decreased expression of DYNLL1 mRNA CTD PMID:24136188 NCBI chr12:41,312,365...41,316,157
Ensembl chr12:41,312,367...41,314,741 		JBrowse link
G E2f1 E2F transcription factor 1 decreases expression ISO Sulindac results in decreased expression of E2F1 protein CTD PMID:16488075 NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361 		JBrowse link
G Eci2 enoyl-CoA delta isomerase 2 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of ECI2 mRNA CTD PMID:20371263 NCBI chr17:29,850,884...29,886,781
Ensembl chr17:29,870,391...29,886,781 		JBrowse link
G Egf epidermal growth factor multiple interactions ISO Sulindac inhibits the reaction [EGF protein results in increased phosphorylation of BAD protein]; Sulindac inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; Sulindac inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein] CTD PMID:12566304 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Ehmt2 euchromatic histone lysine methyltransferase 2 decreases expression ISO Sulindac results in decreased expression of EHMT2 mRNA CTD PMID:11906190 NCBI chr20:3,919,623...3,936,751
Ensembl chr20:3,919,624...3,941,547 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases expression ISO Sulindac results in increased expression of EIF2AK3 mRNA CTD PMID:32535746 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Eif5b eukaryotic translation initiation factor 5B increases expression EXP Sulindac results in increased expression of EIF5B mRNA CTD PMID:24136188 NCBI chr 9:40,222,769...40,277,482
Ensembl chr 9:40,222,898...40,277,482 		JBrowse link
G Elapor2 endosome-lysosome associated apoptosis and autophagy regulator family member 2 increases expression ISO Sulindac results in increased expression of ELAPOR2 mRNA CTD PMID:11906190 NCBI chr 4:24,613,163...24,805,729
Ensembl chr 4:24,613,163...24,805,729 		JBrowse link
G Eloc elongin C increases expression EXP Sulindac results in increased expression of ELOC mRNA CTD PMID:24136188 NCBI chr 5:2,661,527...2,677,893
Ensembl chr 5:2,661,724...2,677,890 		JBrowse link
G Endog endonuclease G affects localization ISO Sulindac affects the localization of ENDOG protein CTD PMID:15946692 NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932 		JBrowse link
G Ercc5 ERCC excision repair 5, endonuclease decreases expression ISO Sulindac results in decreased expression of ERCC5 mRNA CTD PMID:11906190 NCBI chr 9:46,309,477...46,354,478
Ensembl chr 9:46,309,389...46,354,472 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 increases expression ISO Sulindac results in increased expression of ERN1 mRNA CTD PMID:32535746 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029 		JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 decreases expression EXP Sulindac results in decreased expression of ERRFI1 mRNA CTD PMID:24136188 NCBI chr 5:161,323,981...161,337,289
Ensembl chr 5:161,323,998...161,337,282 		JBrowse link
G Ess2 ess-2 splicing factor homolog increases expression ISO Sulindac results in increased expression of ESS2 mRNA CTD PMID:11906190 NCBI chr11:83,075,893...83,085,849
Ensembl chr11:83,075,925...83,084,846 		JBrowse link
G Etfdh electron transfer flavoprotein dehydrogenase decreases expression EXP Sulindac results in decreased expression of ETFDH mRNA CTD PMID:24136188 NCBI chr 2:164,740,547...164,762,754
Ensembl chr 2:164,729,749...164,762,745 		JBrowse link
G Ets1 ETS proto-oncogene 1, transcription factor increases expression ISO Sulindac results in increased expression of ETS1 mRNA CTD PMID:11906190 NCBI chr 8:31,045,909...31,168,010
Ensembl chr 8:31,045,945...31,168,010 		JBrowse link
G Exoc3 exocyst complex component 3 decreases expression EXP Sulindac results in decreased expression of EXOC3 mRNA CTD PMID:24136188 NCBI chr 1:29,091,298...29,122,056
Ensembl chr 1:29,091,294...29,122,045 		JBrowse link
G Exoc7 exocyst complex component 7 increases expression EXP Sulindac results in increased expression of EXOC7 mRNA CTD PMID:24136188 NCBI chr10:101,521,630...101,540,425
Ensembl chr10:101,520,927...101,540,561 		JBrowse link
G Exosc5 exosome component 5 decreases expression EXP Sulindac results in decreased expression of EXOSC5 mRNA CTD PMID:24136188 NCBI chr 1:81,168,128...81,177,266
Ensembl chr 1:81,166,023...81,177,265 		JBrowse link
G Exosc7 exosome component 7 decreases expression EXP Sulindac results in decreased expression of EXOSC7 mRNA CTD PMID:24136188 NCBI chr 8:122,773,607...122,798,943
Ensembl chr 8:122,773,591...122,799,270 		JBrowse link
G Fam219b family with sequence similarity 219, member B decreases expression EXP Sulindac results in decreased expression of FAM219B mRNA CTD PMID:24136188 NCBI chr 8:57,941,327...57,946,916
Ensembl chr 8:57,941,294...57,946,906 		JBrowse link
G Fam241b family with sequence similarity 241 member B increases expression EXP Sulindac results in increased expression of FAM241B mRNA CTD PMID:24136188 NCBI chr20:30,052,315...30,055,247
Ensembl chr20:30,052,324...30,055,084 		JBrowse link
G Fasn fatty acid synthase increases expression ISO Sulindac results in increased expression of FASN mRNA CTD PMID:32535746 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Fbxl4 F-box and leucine-rich repeat protein 4 increases expression EXP Sulindac results in increased expression of FBXL4 mRNA CTD PMID:24136188 NCBI chr 5:35,955,801...36,029,446
Ensembl chr 5:35,955,812...36,029,443 		JBrowse link
G Fbxo42 F-box protein 42 increases expression ISO Sulindac results in increased expression of FBXO42 mRNA CTD PMID:11906190 NCBI chr 5:153,451,162...153,509,564
Ensembl chr 5:153,451,153...153,506,342 		JBrowse link
G Fbxo6 F-box protein 6 decreases expression EXP Sulindac results in decreased expression of FBXO6 mRNA CTD PMID:24136188 NCBI chr 5:158,576,729...158,582,520
Ensembl chr 5:158,576,759...158,582,525 		JBrowse link
G Fhl2 four and a half LIM domains 2 increases expression ISO Sulindac results in increased expression of FHL2 mRNA CTD PMID:11906190 NCBI chr 9:45,388,979...45,462,421
Ensembl chr 9:45,388,981...45,431,192 		JBrowse link
G Fkbp1a FKBP prolyl isomerase 1A decreases expression EXP Sulindac results in decreased expression of FKBP1A mRNA CTD PMID:24136188 NCBI chr 3:140,040,359...140,060,107
Ensembl chr 3:140,040,278...140,060,743 		JBrowse link
G Fli1 Fli-1 proto-oncogene, ETS transcription factor decreases expression EXP Sulindac results in decreased expression of FLI1 mRNA CTD PMID:24136188 NCBI chr 8:30,831,422...30,950,468
Ensembl chr 8:30,832,753...30,950,433 		JBrowse link
G Flnb filamin B increases expression EXP Sulindac results in increased expression of FLNB mRNA CTD PMID:24136188 NCBI chr15:16,961,999...17,095,059
Ensembl chr15:16,962,003...17,095,006 		JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 affects metabolic processing
increases metabolic processing
multiple interactions		 ISO FMO3 gene polymorphism affects the metabolism of Sulindac
FMO3 protein results in increased metabolism of Sulindac
FMO3 gene polymorphism results in decreased metabolism of and results in increased susceptibility to Sulindac		 CTD PMID:15623613 PMID:17050781 NCBI chr13:75,309,367...75,334,915
Ensembl chr13:75,309,374...75,328,028 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression ISO Sulindac results in decreased expression of FOS protein CTD PMID:15020200 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Fth1 ferritin heavy chain 1 increases expression ISO Sulindac results in increased expression of FTH1 mRNA CTD PMID:11093808 NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424 		JBrowse link
G Ftl1 ferritin light chain 1 decreases expression EXP Sulindac results in decreased expression of FTL1 mRNA CTD PMID:24136188 NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725
Ensembl chr10:95,936,387...95,939,725 		JBrowse link
G Fxn frataxin increases expression EXP Sulindac results in increased expression of FXN mRNA CTD PMID:24136188 NCBI chr 1:221,874,007...221,897,543
Ensembl chr 1:221,872,420...221,897,540 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO Sulindac results in increased expression of GADD45A mRNA CTD PMID:11906190 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115 		JBrowse link
G Gal galanin and GMAP prepropeptide affects expression ISO Sulindac affects the expression of GAL protein CTD PMID:12388792 NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959 		JBrowse link
G Galk1 galactokinase 1 increases expression EXP Sulindac results in increased expression of GALK1 mRNA CTD PMID:24136188 NCBI chr10:101,243,146...101,247,323
Ensembl chr10:101,235,994...101,247,337 		JBrowse link
G Gap43 growth associated protein 43 affects expression ISO Sulindac affects the expression of GAP43 protein CTD PMID:12388792 NCBI chr11:58,376,371...58,470,047
Ensembl chr11:58,376,371...58,470,045 		JBrowse link
G Gatad1 GATA zinc finger domain containing 1 increases expression EXP Sulindac results in increased expression of GATAD1 mRNA CTD PMID:24136188 NCBI chr 4:30,507,530...30,519,107
Ensembl chr 4:30,507,538...30,519,107 		JBrowse link
G Gatad2a GATA zinc finger domain containing 2A increases expression EXP Sulindac results in increased expression of GATAD2A mRNA CTD PMID:24136188 NCBI chr16:19,429,578...19,520,320
Ensembl chr16:19,429,578...19,519,587 		JBrowse link
G Gatd3a glutamine amidotransferase class 1 domain containing 3A decreases expression ISO Sulindac results in decreased expression of GATD3 mRNA CTD PMID:11906190 NCBI chr20:10,514,793...10,522,894
Ensembl chr20:10,514,744...10,522,885 		JBrowse link
G Gba1 glucosylceramidase beta 1 multiple interactions ISO Sulindac inhibits the reaction [CDKN1A protein results in increased expression of GBA1 mRNA] CTD PMID:15190207 NCBI chr 2:174,609,437...174,615,457
Ensembl chr 2:174,609,403...174,618,263 		JBrowse link
G Gcdh glutaryl-CoA dehydrogenase multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of GCDH mRNA CTD PMID:20371263 NCBI chr19:23,263,215...23,269,689
Ensembl chr19:23,263,264...23,269,681 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
increases expression
affects expression		 ISO Acetylcysteine inhibits the reaction [Sulindac results in increased expression of GCLC protein]
Sulindac affects the expression of GCLC mRNA		 CTD PMID:11820781 PMID:15946948 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gcnt1 glucosaminyl (N-acetyl) transferase 1 increases expression ISO Sulindac results in increased expression of GCNT1 mRNA CTD PMID:11093808 NCBI chr 1:214,718,344...214,755,735
Ensembl chr 1:214,718,293...214,758,776 		JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO Sulindac results in increased expression of GDF15 mRNA; Sulindac results in increased expression of GDF15 protein CTD PMID:11906190 PMID:11984525 PMID:15180942 NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055 		JBrowse link
G Ghitm growth hormone inducible transmembrane protein increases expression EXP Sulindac results in increased expression of GHITM mRNA CTD PMID:24136188 NCBI chr16:12,885,551...12,897,887
Ensembl chr16:12,885,553...12,897,879 		JBrowse link
G Ghr growth hormone receptor multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of GHR mRNA CTD PMID:20371263 NCBI chr 2:52,541,452...52,804,960
Ensembl chr 2:52,542,594...52,804,735 		JBrowse link
G Glo1 glyoxalase 1 decreases activity ISO Sulindac results in decreased activity of GLO1 protein CTD PMID:17243824 NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649 		JBrowse link
G Gnas GNAS complex locus increases expression EXP Sulindac results in increased expression of GNAS mRNA CTD PMID:24136188 NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262 		JBrowse link
G Gnl3l G protein nucleolar 3 like decreases expression EXP Sulindac results in decreased expression of GNL3L mRNA CTD PMID:24136188 NCBI chr  X:19,961,277...19,994,454
Ensembl chr  X:19,958,603...19,994,508 		JBrowse link
G Gnmt glycine N-methyltransferase decreases expression EXP Sulindac results in decreased expression of GNMT mRNA CTD PMID:24136188 NCBI chr 9:14,254,675...14,258,028
Ensembl chr 9:14,254,675...14,258,434 		JBrowse link
G Gpx3 glutathione peroxidase 3 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of GPX3 mRNA CTD PMID:20371263 NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035 		JBrowse link
G Grb10 growth factor receptor bound protein 10 increases expression ISO Sulindac results in increased expression of GRB10 mRNA CTD PMID:11906190 NCBI chr14:86,495,051...86,602,800
Ensembl chr14:86,495,054...86,602,806 		JBrowse link
G Grb2 growth factor receptor bound protein 2 increases expression EXP Sulindac results in increased expression of GRB2 mRNA CTD PMID:24136188 NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309 		JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 affects expression EXP Sulindac affects the expression of GRIN1 protein CTD PMID:15123337 NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B affects expression EXP Sulindac affects the expression of GRIN2B protein CTD PMID:15123337 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279 		JBrowse link
G Grk6 G protein-coupled receptor kinase 6 decreases expression EXP Sulindac results in decreased expression of GRK6 mRNA CTD PMID:24136188 NCBI chr17:9,177,018...9,192,813
Ensembl chr17:9,177,019...9,192,644 		JBrowse link
G Grn granulin precursor multiple interactions ISO Sulindac inhibits the reaction [CDKN1A protein results in increased expression of GRN mRNA] CTD PMID:15190207 NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases phosphorylation ISO Sulindac results in decreased phosphorylation of GSK3B protein CTD PMID:11593435 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Gstm2 glutathione S-transferase mu 2 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of GSTM2 mRNA CTD PMID:20371263 NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961 		JBrowse link
G Gstt1 glutathione S-transferase theta 1 increases expression EXP Sulindac results in increased expression of GSTT1 protein CTD PMID:9729437 NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585 		JBrowse link
G Gtf2b general transcription factor IIB increases expression
decreases expression		 ISO
EXP		 Sulindac results in increased expression of GTF2B mRNA
Sulindac results in decreased expression of GTF2B mRNA		 CTD PMID:11906190 PMID:24136188 NCBI chr 2:231,767,317...231,785,626
Ensembl chr 2:231,767,238...231,785,651 		JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO [Arsenic Trioxide co-treated with Sulindac] results in increased phosphorylation of H2AX protein CTD PMID:18636201 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G H2az1 H2A.Z variant histone 1 increases expression EXP Sulindac results in increased expression of H2AZ1 mRNA CTD PMID:24136188 NCBI chr 2:226,355,668...226,357,984
Ensembl chr 2:226,355,708...226,358,485 		JBrowse link
G Hadhb hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta decreases expression EXP Sulindac results in decreased expression of HADHB mRNA CTD PMID:24136188 NCBI chr 6:26,153,572...26,187,668
Ensembl chr 6:26,153,578...26,184,869 		JBrowse link
G Helz2 helicase with zinc finger 2 decreases expression EXP Sulindac results in decreased expression of HELZ2 mRNA CTD PMID:24136188 NCBI chr 3:168,338,813...168,353,219
Ensembl chr 3:168,338,813...168,353,159 		JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 increases expression ISO Sulindac results in increased expression of HERPUD1 mRNA CTD PMID:11093808 NCBI chr19:10,598,411...10,609,002
Ensembl chr19:10,598,417...10,618,424 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
decreases expression		 ISO [AKT1 protein affects the reaction [Sulindac analog results in decreased expression of HIF1A protein]] which affects the susceptibility to Oxygen; AKT1 protein affects the reaction [Sulindac analog results in decreased expression of HIF1A protein]
Sulindac analog results in decreased expression of HIF1A mRNA; Sulindac analog results in decreased expression of HIF1A protein		 CTD PMID:18924134 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Higd1a HIG1 hypoxia inducible domain family, member 1A increases expression EXP Sulindac results in increased expression of HIGD1A mRNA CTD PMID:24136188 NCBI chr 8:121,514,152...121,523,382
Ensembl chr 8:121,514,156...121,523,443 		JBrowse link
G Hlcs holocarboxylase synthetase decreases expression ISO Sulindac results in decreased expression of HLCS mRNA CTD PMID:11906190 NCBI chr11:33,455,806...33,635,197
Ensembl chr11:33,455,809...33,624,222 		JBrowse link
G Hmgb3 high mobility group box 3 increases expression EXP Sulindac results in increased expression of HMGB3 mRNA CTD PMID:24136188 NCBI chr  X:149,296,303...149,301,290
Ensembl chr  X:149,296,375...149,301,292 		JBrowse link
G Hmmr hyaluronan-mediated motility receptor decreases expression ISO Sulindac results in decreased expression of HMMR mRNA CTD PMID:11906190 NCBI chr10:25,132,933...25,163,029
Ensembl chr10:25,132,977...25,163,060 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
decreases expression		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Sulindac promotes the reaction [arsenic trioxide results in increased expression of HMOX1 protein]]; pyrazolanthrone inhibits the reaction [Sulindac promotes the reaction [arsenic trioxide results in increased expression of HMOX1 protein]]; SB 203580 inhibits the reaction [Sulindac promotes the reaction [arsenic trioxide results in increased expression of HMOX1 protein]]; Sulindac promotes the reaction [arsenic trioxide results in increased expression of HMOX1 protein]
Sulindac results in decreased expression of HMOX1 protein		 CTD PMID:18636201 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of HNF4A mRNA CTD PMID:20371263 NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320 		JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of HSD17B4 mRNA CTD PMID:20371263 NCBI chr18:43,328,903...43,417,950
Ensembl chr18:43,328,824...43,417,952 		JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity ISO Sulindac results in increased activity of HSF1 protein CTD PMID:10328874 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011 		JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 increases expression EXP Sulindac results in increased expression of HSPA9 mRNA CTD PMID:24136188 NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292 		JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression ISO Sulindac results in decreased expression of ICAM1 protein CTD PMID:18059344 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Ifi27 interferon, alpha-inducible protein 27 decreases expression EXP Sulindac results in decreased expression of IFI27 mRNA CTD PMID:24136188 NCBI chr 6:122,590,461...122,596,996
Ensembl chr 6:122,590,472...122,779,294 		JBrowse link
G Ifitm3 interferon induced transmembrane protein 3 decreases expression EXP Sulindac results in decreased expression of IFITM3 mRNA CTD PMID:24136188 NCBI chr 1:196,111,026...196,112,135
Ensembl chr 1:196,111,043...196,112,203 		JBrowse link
G Ifnar1 interferon alpha and beta receptor subunit 1 decreases expression EXP Sulindac results in decreased expression of IFNAR1 mRNA CTD PMID:24136188 NCBI chr11:30,725,774...30,752,227
Ensembl chr11:30,725,790...30,749,979 		JBrowse link
G Ifng interferon gamma multiple interactions ISO Sulindac inhibits the reaction [IFNG protein results in increased expression of CXCL9 mRNA] CTD PMID:17010317 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Iftap intraflagellar transport associated protein increases expression EXP Sulindac results in increased expression of IFTAP mRNA CTD PMID:24136188 NCBI chr 3:87,812,068...87,906,517
Ensembl chr 3:87,817,408...87,906,547 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta decreases activity ISO Sulindac results in decreased activity of IKBKB protein CTD PMID:19526344 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Il11ra1 interleukin 11 receptor subunit alpha 1 increases expression EXP Sulindac results in increased expression of IL11RA1 mRNA CTD PMID:24136188 NCBI chr 5:56,931,824...56,941,408
Ensembl chr 5:56,935,516...56,941,408 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of IL1A mRNA CTD PMID:20371263 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
decreases expression		 ISO
EXP		 [Sulindac co-treated with epigallocatechin gallate] results in decreased expression of IL1B mRNA; Sulindac inhibits the reaction [IL1B protein results in increased abundance of Hyaluronic Acid]; Sulindac inhibits the reaction [IL1B protein results in increased expression of CCL5 mRNA]
Sulindac results in increased expression of IL1B
Sulindac results in decreased expression of IL1B protein
Sulindac results in decreased expression of IL1B mRNA		 CTD PMID:10328874 PMID:11318944 PMID:12628509 PMID:15123337 PMID:16159934 More... NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il24 interleukin 24 multiple interactions
increases expression		 ISO Sulindac promotes the reaction [IL24 protein results in increased phosphorylation of MAPK8 protein]
[Sulindac results in increased expression of IL24 protein] which results in increased expression of CASP3 protein; [Sulindac results in increased expression of IL24 protein] which results in increased expression of CASP9 protein; Sulindac results in increased expression of IL24 protein		 CTD PMID:15713900 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression		 EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of IL6 mRNA
Sulindac results in increased expression of IL6		 CTD PMID:20371263 PMID:24136188 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ilk integrin-linked kinase decreases activity ISO Sulindac results in decreased activity of ILK protein CTD PMID:11593435 NCBI chr 1:160,088,839...160,095,140
Ensembl chr 1:160,088,897...160,095,140 		JBrowse link
G Inpp5e inositol polyphosphate-5-phosphatase E increases expression ISO Sulindac results in increased expression of INPP5E mRNA CTD PMID:11906190 NCBI chr 3:9,216,776...9,229,539
Ensembl chr 3:9,216,776...9,229,450 		JBrowse link
G Ipmk inositol polyphosphate multikinase decreases expression EXP Sulindac results in decreased expression of IPMK mRNA CTD PMID:24136188 NCBI chr20:17,216,988...17,251,675
Ensembl chr20:17,218,037...17,251,705 		JBrowse link
G Irak2 interleukin-1 receptor-associated kinase 2 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of IRAK2 mRNA CTD PMID:20371263 NCBI chr 4:146,786,004...146,842,615
Ensembl chr 4:146,786,100...146,842,602 		JBrowse link
G Irf7 interferon regulatory factor 7 decreases expression EXP Sulindac results in decreased expression of IRF7 mRNA CTD PMID:24136188 NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832 		JBrowse link
G Isca1 iron-sulfur cluster assembly 1 decreases expression EXP Sulindac results in decreased expression of ISCA1 mRNA CTD PMID:24136188 NCBI chr17:4,905,291...4,917,955
Ensembl chr17:4,905,287...4,917,955 		JBrowse link
G Itga2 integrin subunit alpha 2 increases expression ISO Sulindac results in increased expression of ITGA2 mRNA CTD PMID:11906190 NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481 		JBrowse link
G Itgb3 integrin subunit beta 3 multiple interactions ISO Sulindac inhibits the reaction [CDKN1A protein results in increased expression of ITGB3 mRNA] CTD PMID:15190207 NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679 		JBrowse link
G Itgb4 integrin subunit beta 4 multiple interactions ISO [Sulindac co-treated with epigallocatechin gallate] results in decreased expression of ITGB4 mRNA CTD PMID:12628509 NCBI chr10:101,206,657...101,243,012
Ensembl chr10:101,206,665...101,243,012 		JBrowse link
G Jkamp JNK1/MAPK8-associated membrane protein decreases expression EXP Sulindac results in decreased expression of JKAMP mRNA CTD PMID:24136188 NCBI chr 6:90,648,043...90,661,985
Ensembl chr 6:90,648,160...90,662,501 		JBrowse link
G Josd1 Josephin domain containing 1 decreases expression EXP Sulindac results in decreased expression of JOSD1 mRNA CTD PMID:24136188 NCBI chr 7:111,230,318...111,244,241
Ensembl chr 7:111,230,318...111,244,652 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases expression
multiple interactions		 ISO Sulindac results in decreased expression of JUN protein
[Sulindac co-treated with Plant Extracts] results in decreased expression of JUN protein		 CTD PMID:12351151 PMID:12584176 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit increases expression ISO Sulindac results in increased expression of JUND mRNA CTD PMID:11906190 NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799 		JBrowse link
G Kcnh3 potassium voltage-gated channel subfamily H member 3 decreases expression EXP Sulindac results in decreased expression of KCNH3 mRNA CTD PMID:24136188 NCBI chr 7:130,365,593...130,383,859
Ensembl chr 7:130,366,011...130,383,855 		JBrowse link
G Kctd5 potassium channel tetramerization domain containing 5 increases expression EXP Sulindac results in increased expression of KCTD5 mRNA CTD PMID:24136188 NCBI chr10:13,079,216...13,105,197
Ensembl chr10:13,079,214...13,105,209 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 decreases expression EXP Sulindac results in decreased expression of KEAP1 mRNA CTD PMID:24136188 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862 		JBrowse link
G Khsrp KH-type splicing regulatory protein increases expression EXP Sulindac results in increased expression of KHSRP mRNA CTD PMID:24136188 NCBI chr 9:1,862,555...1,872,403
Ensembl chr 9:1,862,899...1,872,451 		JBrowse link
G Kif14 kinesin family member 14 increases expression ISO Sulindac results in increased expression of KIF14 mRNA CTD PMID:11906190 NCBI chr13:47,926,975...47,990,598
Ensembl chr13:47,927,044...47,989,164 		JBrowse link
G Klf5 KLF transcription factor 5 increases expression ISO Sulindac results in increased expression of KLF5 mRNA CTD PMID:11906190 NCBI chr15:76,060,320...76,079,445
Ensembl chr15:76,064,258...76,079,445 		JBrowse link
G Kras KRAS proto-oncogene, GTPase affects response to substance ISO KRAS protein affects the susceptibility to Sulindac CTD PMID:11751493 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Lad1 ladinin 1 increases expression ISO Sulindac results in increased expression of LAD1 mRNA CTD PMID:11507085 NCBI chr13:47,249,605...47,263,967
Ensembl chr13:47,249,605...47,263,967 		JBrowse link
G Lamtor4 late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 decreases expression EXP Sulindac results in decreased expression of LAMTOR4 mRNA CTD PMID:24136188 NCBI chr12:17,258,656...17,262,478
Ensembl chr12:17,258,623...17,262,480 		JBrowse link
G Larp1b La ribonucleoprotein 1B decreases expression EXP Sulindac results in decreased expression of LARP1B mRNA CTD PMID:24136188 NCBI chr 2:123,936,057...123,969,254
Ensembl chr 2:123,935,983...123,968,896 		JBrowse link
G Larp4 La ribonucleoprotein 4 increases expression ISO Sulindac results in increased expression of LARP4 mRNA CTD PMID:11906190 NCBI chr 7:131,104,470...131,152,692
Ensembl chr 7:131,101,564...131,150,811 		JBrowse link
G Lbp lipopolysaccharide binding protein multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of LBP mRNA CTD PMID:20371263 NCBI chr 3:146,953,889...146,981,032
Ensembl chr 3:146,954,015...146,981,586 		JBrowse link
G Ldb1 LIM domain binding 1 increases expression ISO Sulindac results in increased expression of LDB1 mRNA CTD PMID:11906190 NCBI chr 1:244,864,168...244,890,007
Ensembl chr 1:244,877,173...244,890,013 		JBrowse link
G Lef1 lymphoid enhancer binding factor 1 multiple interactions ISO Sulindac results in decreased activity of [LEF1 protein binds to CTNNB1 protein] CTD PMID:11751639 NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794 		JBrowse link
G Lfng LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase increases expression ISO Sulindac results in increased expression of LFNG mRNA CTD PMID:11906190 NCBI chr12:14,030,551...14,038,996
Ensembl chr12:14,018,333...14,039,008 		JBrowse link
G Lgals3 galectin 3 multiple interactions ISO Sulindac inhibits the reaction [CDKN1A protein results in increased expression of LGALS3 mRNA] CTD PMID:15190207 NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025 		JBrowse link
G Lgals3bp galectin 3 binding protein multiple interactions ISO Sulindac inhibits the reaction [CDKN1A protein results in increased expression of LGALS3BP mRNA] CTD PMID:15190207 NCBI chr10:103,619,912...103,629,251
Ensembl chr10:103,619,908...103,629,256 		JBrowse link
G Lipe lipase E, hormone sensitive type decreases expression EXP Sulindac results in decreased expression of LIPE mRNA CTD PMID:24136188 NCBI chr 1:80,965,612...80,984,313
Ensembl chr 1:80,965,627...80,984,310 		JBrowse link
G Litaf lipopolysaccharide-induced TNF factor increases expression EXP Sulindac results in increased expression of LITAF mRNA CTD PMID:24136188 NCBI chr10:4,656,308...4,692,981
Ensembl chr10:4,625,552...4,692,763 		JBrowse link
G Lmf2 lipase maturation factor 2 decreases expression EXP Sulindac results in decreased expression of LMF2 mRNA CTD PMID:24136188 NCBI chr 7:120,418,343...120,422,825
Ensembl chr 7:120,418,345...120,422,823 		JBrowse link
G Lonp1 lon peptidase 1, mitochondrial decreases expression EXP Sulindac results in decreased expression of LONP1 mRNA CTD PMID:24136188 NCBI chr 9:1,447,444...1,459,771
Ensembl chr 9:1,447,447...1,459,771 		JBrowse link
G Lox lysyl oxidase decreases expression ISO Sulindac analog results in decreased expression of LOX mRNA CTD PMID:18924134 NCBI chr18:45,964,544...45,977,431
Ensembl chr18:45,967,343...46,041,477 		JBrowse link
G Lrpprc leucine-rich pentatricopeptide repeat containing decreases expression EXP Sulindac results in decreased expression of LRPPRC mRNA CTD PMID:24136188 NCBI chr 6:9,859,816...9,942,294
Ensembl chr 6:9,859,867...9,942,293 		JBrowse link
G Lsm10 LSM10, U7 small nuclear RNA associated increases expression EXP Sulindac results in increased expression of LSM10 mRNA CTD PMID:24136188 NCBI chr 5:138,365,983...138,375,856
Ensembl chr 5:138,373,119...138,377,505 		JBrowse link
G Lsm12 LSM12 homolog increases expression EXP Sulindac results in increased expression of LSM12 mRNA CTD PMID:24136188 NCBI chr10:87,118,334...87,140,395
Ensembl chr10:87,118,416...87,140,396 		JBrowse link
G Lsm6 LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated increases expression EXP Sulindac results in increased expression of LSM6 mRNA CTD PMID:24136188 NCBI chr19:29,098,254...29,112,858
Ensembl chr13:42,114,032...42,116,484
Ensembl chr19:42,114,032...42,116,484 		JBrowse link
G Macroh2a1 macroH2A.1 histone decreases expression EXP Sulindac results in decreased expression of MACROH2A1 mRNA CTD PMID:24136188 NCBI chr17:8,479,331...8,542,071
Ensembl chr17:8,479,372...8,542,072 		JBrowse link
G Maoa monoamine oxidase A decreases expression EXP Sulindac results in decreased expression of MAOA mRNA CTD PMID:24136188 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593 		JBrowse link
G Maob monoamine oxidase B multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of MAOB mRNA CTD PMID:20371263 NCBI chr  X:5,907,327...6,010,996
Ensembl chr  X:5,907,266...6,011,003 		JBrowse link
G Map3k8 mitogen-activated protein kinase kinase kinase 8 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of MAP3K8 mRNA CTD PMID:20371263 NCBI chr17:53,382,908...53,403,216
Ensembl chr17:53,383,131...53,403,216 		JBrowse link
G Map4k3 mitogen-activated protein kinase kinase kinase kinase 3 increases expression ISO Sulindac results in increased expression of MAP4K3 mRNA CTD PMID:11906190 NCBI chr 6:14,276,623...14,446,321
Ensembl chr 6:14,277,121...14,446,334 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO
EXP		 [Sulindac co-treated with Arsenic Trioxide] results in increased phosphorylation of MAPK1 protein; Arsenic Trioxide promotes the reaction [Sulindac results in increased phosphorylation of MAPK1 protein]; Sulindac inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; Sulindac promotes the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK1 protein]
[Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of MAPK1 mRNA		 CTD PMID:12566304 PMID:18281123 PMID:18636201 PMID:20371263 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO [Sulindac co-treated with Arsenic Trioxide] results in increased phosphorylation of MAPK3 protein; Arsenic Trioxide promotes the reaction [Sulindac results in increased phosphorylation of MAPK3 protein]; Sulindac inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; Sulindac promotes the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK3 protein] CTD PMID:12566304 PMID:18281123 PMID:18636201 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation
increases expression		 ISO CDKN1A protein promotes the reaction [Sulindac results in increased expression of and results in increased phosphorylation of MAPK8 protein]; MAPK8 affects the reaction [[Sulindac co-treated with Arsenic Trioxide] results in increased phosphorylation of BCL2L1 protein]; Sulindac promotes the reaction [IL24 protein results in increased phosphorylation of MAPK8 protein]; Sulindac results in increased expression of and results in increased phosphorylation of MAPK8 protein; Sulindac results in increased phosphorylation of and results in increased activity of MAPK8 protein
Sulindac results in increased phosphorylation of MAPK8 protein
Sulindac results in increased expression of MAPK8 mRNA		 CTD PMID:15713900 PMID:17292881 PMID:18281123 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mark3 microtubule affinity regulating kinase 3 decreases expression EXP Sulindac results in decreased expression of MARK3 mRNA CTD PMID:24136188 NCBI chr 6:130,626,612...130,716,245
Ensembl chr 6:130,627,482...130,716,647 		JBrowse link
G Mbd2 methyl-CpG binding domain protein 2 decreases expression EXP Sulindac results in decreased expression of MBD2 mRNA CTD PMID:24136188 NCBI chr18:64,174,002...64,240,795
Ensembl chr18:64,174,002...64,240,794 		JBrowse link
G Mbd3 methyl-CpG binding domain protein 3 decreases expression EXP Sulindac results in decreased expression of MBD3 mRNA CTD PMID:24136188 NCBI chr 7:9,312,961...9,320,166
Ensembl chr 7:9,313,098...9,320,165 		JBrowse link
G Me1 malic enzyme 1 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of ME1 mRNA CTD PMID:20371263 NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304 		JBrowse link
G Med10 mediator complex subunit 10 increases expression EXP Sulindac results in increased expression of MED10 mRNA CTD PMID:24136188 NCBI chr 1:33,470,064...33,481,698
Ensembl chr 1:33,470,066...33,475,767 		JBrowse link
G Med15 mediator complex subunit 15 increases expression ISO Sulindac results in increased expression of MED15 mRNA CTD PMID:11906190 NCBI chr11:83,280,722...83,356,006
Ensembl chr11:83,280,762...83,355,362 		JBrowse link
G Mesd mesoderm development LRP chaperone decreases expression EXP Sulindac results in decreased expression of MESD mRNA CTD PMID:24136188 NCBI chr 1:137,866,707...137,879,999
Ensembl chr 1:137,874,242...137,879,999 		JBrowse link
G Mettl23 methyltransferase 23, arginine increases expression EXP Sulindac results in increased expression of METTL23 mRNA CTD PMID:24136188 NCBI chr10:102,047,090...102,053,379
Ensembl chr10:102,047,314...102,051,977 		JBrowse link
G Mfap3 microfibril associated protein 3 decreases expression EXP Sulindac results in decreased expression of MFAP3 mRNA CTD PMID:24136188 NCBI chr10:41,696,788...41,711,490
Ensembl chr10:41,696,771...41,710,406 		JBrowse link
G Mff mitochondrial fission factor decreases expression EXP Sulindac results in decreased expression of MFF mRNA CTD PMID:24136188 NCBI chr 9:84,007,798...84,036,039
Ensembl chr 9:84,007,798...84,036,039 		JBrowse link
G Mgst2 microsomal glutathione S-transferase 2 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of MGST2 mRNA CTD PMID:20371263 NCBI chr 2:135,679,524...135,715,828
Ensembl chr 2:135,693,557...135,715,828 		JBrowse link
G Mgst3 microsomal glutathione S-transferase 3 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of MGST3 mRNA CTD PMID:20371263 NCBI chr13:79,526,541...79,547,479
Ensembl chr13:79,526,541...79,547,411 		JBrowse link
G Miip migration and invasion inhibitory protein increases expression ISO Sulindac results in increased expression of MIIP mRNA CTD PMID:11906190 NCBI chr 5:158,292,510...158,299,533
Ensembl chr 5:158,292,511...158,299,694 		JBrowse link
G Mllt6 MLLT6, PHD finger containing decreases expression EXP Sulindac results in decreased expression of MLLT6 mRNA CTD PMID:24136188 NCBI chr10:82,657,258...82,678,899
Ensembl chr10:82,656,872...82,676,073 		JBrowse link
G Mmp14 matrix metallopeptidase 14 decreases expression EXP Sulindac results in decreased expression of MMP14 mRNA CTD PMID:24136188 NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864 		JBrowse link
G Mmp7 matrix metallopeptidase 7 decreases expression ISO Sulindac results in decreased expression of MMP7 mRNA; Sulindac results in decreased expression of MMP7 protein CTD PMID:18499699 NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902 		JBrowse link
G Mogs mannosyl-oligosaccharide glucosidase decreases expression EXP Sulindac results in decreased expression of MOGS mRNA CTD PMID:24136188 NCBI chr 4:115,621,623...115,625,026
Ensembl chr 4:115,621,623...115,625,032 		JBrowse link
G Mrpl1 mitochondrial ribosomal protein L1 decreases expression EXP Sulindac results in decreased expression of MRPL1 mRNA CTD PMID:24136188 NCBI chr14:13,300,522...13,359,654
Ensembl chr14:13,300,522...13,359,721 		JBrowse link
G mrpl11 mitochondrial ribosomal protein L11 decreases expression EXP Sulindac results in decreased expression of MRPL11 mRNA CTD PMID:24136188 NCBI chr 1:202,264,419...202,267,288
Ensembl chr 1:202,264,471...202,267,756 		JBrowse link
G Mrpl13 mitochondrial ribosomal protein L13 increases expression EXP Sulindac results in increased expression of MRPL13 mRNA CTD PMID:24136188 NCBI chr 7:86,951,541...86,973,147
Ensembl chr 7:86,951,541...86,973,577 		JBrowse link
G Mrpl17 mitochondrial ribosomal protein L17 decreases expression EXP Sulindac results in decreased expression of MRPL17 mRNA CTD PMID:24136188 NCBI chr 1:160,162,181...160,163,870
Ensembl chr 1:160,158,807...160,163,815 		JBrowse link
G Mrpl20 mitochondrial ribosomal protein L20 decreases expression EXP Sulindac results in decreased expression of MRPL20 mRNA CTD PMID:24136188 NCBI chr 5:166,408,962...166,413,492
Ensembl chr 5:166,408,962...166,413,492 		JBrowse link
G Mrpl22 mitochondrial ribosomal protein L22 increases expression EXP Sulindac results in increased expression of MRPL22 mRNA CTD PMID:24136188 NCBI chr10:42,345,446...42,355,779
Ensembl chr10:42,342,776...42,355,779 		JBrowse link
G Mrpl23 mitochondrial ribosomal protein L23 decreases expression EXP Sulindac results in decreased expression of MRPL23 mRNA CTD PMID:24136188 NCBI chr 1:197,687,452...197,695,222
Ensembl chr 1:197,687,347...197,695,222 		JBrowse link
G Mrpl32 mitochondrial ribosomal protein L32 increases expression EXP Sulindac results in increased expression of MRPL32 mRNA CTD PMID:24136188 NCBI chr17:50,565,133...50,568,000
Ensembl chr17:50,565,055...50,568,010 		JBrowse link
G Mrpl37 mitochondrial ribosomal protein L37 decreases expression EXP Sulindac results in decreased expression of MRPL37 mRNA CTD PMID:24136188 NCBI chr 5:121,827,892...121,846,187
Ensembl chr 5:121,829,111...121,846,176 		JBrowse link
G Mrpl53 mitochondrial ribosomal protein L53 increases expression EXP Sulindac results in increased expression of MRPL53 mRNA CTD PMID:24136188 NCBI chr 4:115,615,329...115,616,219 JBrowse link
G Mrpl54 mitochondrial ribosomal protein L54 increases expression EXP Sulindac results in increased expression of MRPL54 mRNA CTD PMID:24136188 NCBI chr 7:8,452,801...8,455,321
Ensembl chr 7:8,452,716...8,455,321 		JBrowse link
G Mrpl58 mitochondrial ribosomal protein L58 decreases expression EXP Sulindac results in decreased expression of MRPL58 mRNA CTD PMID:24136188 NCBI chr10:100,646,374...100,652,871
Ensembl chr10:100,646,216...100,652,871 		JBrowse link
G Mrps14 mitochondrial ribosomal protein S14 decreases expression EXP Sulindac results in decreased expression of MRPS14 mRNA CTD PMID:24136188 NCBI chr13:72,429,168...72,434,915
Ensembl chr13:72,408,558...72,434,915 		JBrowse link
G Mrps24 mitochondrial ribosomal protein S24 decreases expression EXP Sulindac results in decreased expression of MRPS24 mRNA CTD PMID:24136188 NCBI chr14:80,584,671...80,588,801
Ensembl chr14:80,584,673...80,588,871 		JBrowse link
G Mrps31 mitochondrial ribosomal protein S31 decreases expression EXP Sulindac results in decreased expression of MRPS31 mRNA CTD PMID:24136188 NCBI chr16:69,601,349...69,621,609
Ensembl chr16:69,601,349...69,630,654 		JBrowse link
G Mrps33 mitochondrial ribosomal protein S33 increases expression EXP Sulindac results in increased expression of MRPS33 mRNA CTD PMID:24136188 NCBI chr 4:68,596,729...68,605,547
Ensembl chr 4:68,596,729...68,605,428 		JBrowse link
G Mrps7 mitochondrial ribosomal protein S7 decreases expression EXP Sulindac results in decreased expression of MRPS7 mRNA CTD PMID:24136188 NCBI chr10:100,843,691...100,846,838
Ensembl chr10:100,843,356...100,847,129 		JBrowse link
G Mrps9 mitochondrial ribosomal protein S9 increases expression EXP Sulindac results in increased expression of MRPS9 mRNA CTD PMID:24136188 NCBI chr 9:45,113,554...45,172,375
Ensembl chr 9:45,113,554...45,172,375 		JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase increases expression ISO Sulindac results in increased expression of MTHFD2 mRNA CTD PMID:11906190 NCBI chr 4:115,811,135...115,822,663
Ensembl chr 4:115,811,139...115,822,608 		JBrowse link
G Mtpn myotrophin increases expression EXP Sulindac results in increased expression of MTPN mRNA CTD PMID:24136188 NCBI chr 4:64,159,273...64,186,686
Ensembl chr 4:64,157,641...64,186,724 		JBrowse link
G Mttp microsomal triglyceride transfer protein increases expression ISO Sulindac results in increased expression of MTTP mRNA CTD PMID:32535746 NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239 		JBrowse link
G Mug1 murinoglobulin 1 decreases expression EXP Sulindac results in decreased expression of MUG1 mRNA CTD PMID:24136188 NCBI chr 4:155,076,270...155,130,051
Ensembl chr 4:155,076,312...155,130,051 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
decreases expression
increases expression		 ISO
EXP		 CTNNB1 protein affects the reaction [Sulindac results in decreased expression of MYC protein]
Sulindac inhibits the reaction [Azoxymethane results in increased expression of MYC mRNA]; Sulindac inhibits the reaction [Azoxymethane results in increased expression of MYC protein]
Sulindac results in increased expression of MYC mRNA		 CTD PMID:12189186 PMID:12414619 PMID:17292881 PMID:18291362 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Mzf1 myeloid zinc finger 1 decreases expression EXP Sulindac results in decreased expression of MZF1 mRNA CTD PMID:24136188 NCBI chr 1:73,670,522...73,682,885
Ensembl chr 1:73,670,541...73,681,635 		JBrowse link
G Naa35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit decreases expression EXP Sulindac results in decreased expression of NAA35 mRNA CTD PMID:24136188 NCBI chr17:5,034,360...5,086,456
Ensembl chr17:5,034,356...5,086,386 		JBrowse link
G Nampt nicotinamide phosphoribosyltransferase decreases expression EXP Sulindac results in decreased expression of NAMPT mRNA CTD PMID:24136188 NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100 		JBrowse link
G Nap1l1 nucleosome assembly protein 1-like 1 decreases expression ISO Sulindac results in decreased expression of NAP1L1 mRNA CTD PMID:11507085 NCBI chr 7:46,933,278...46,957,853
Ensembl chr 7:46,933,356...46,956,593 		JBrowse link
G Nat1 N-acetyltransferase 1 decreases expression ISO Sulindac results in decreased expression of NAT1 mRNA CTD PMID:11828994 NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520 		JBrowse link
G Ndrg1 N-myc downstream regulated 1 increases expression
decreases expression		 ISO
EXP		 Sulindac results in increased expression of NDRG1 mRNA
Sulindac results in decreased expression of NDRG1 mRNA		 CTD PMID:16273229 PMID:24136188 NCBI chr 7:98,684,487...98,725,869
Ensembl chr 7:98,684,487...98,725,880 		JBrowse link
G Ndst2 N-deacetylase and N-sulfotransferase 2 decreases expression ISO Sulindac results in decreased expression of NDST2 mRNA CTD PMID:11906190 NCBI chr15:3,563,515...3,573,801
Ensembl chr15:3,563,358...3,573,801 		JBrowse link
G Ndufa5 NADH:ubiquinone oxidoreductase subunit A5 increases expression EXP Sulindac results in increased expression of NDUFA5 mRNA CTD PMID:24136188 NCBI chr 4:52,997,327...53,005,685
Ensembl chr 4:52,995,546...53,005,598 		JBrowse link
G Ndufv3 NADH:ubiquinone oxidoreductase subunit V3 increases expression EXP Sulindac results in increased expression of NDUFV3 mRNA CTD PMID:24136188 NCBI chr20:9,612,462...9,621,622
Ensembl chr20:9,612,431...9,623,074
Ensembl chr13:9,612,431...9,623,074 		JBrowse link
G Nek7 NIMA-related kinase 7 decreases expression EXP Sulindac results in decreased expression of NEK7 mRNA CTD PMID:24136188 NCBI chr13:50,022,212...50,149,374
Ensembl chr13:50,022,218...50,149,296 		JBrowse link
G Neu1 neuraminidase 1 increases expression ISO Sulindac results in increased expression of NEU1 mRNA CTD PMID:11906190 NCBI chr20:3,897,480...3,901,745
Ensembl chr20:3,897,480...3,901,745 		JBrowse link
G Nfe2l1 NFE2 like bZIP transcription factor 1 increases expression ISO
EXP		 Sulindac results in increased expression of NFE2L1 mRNA CTD PMID:11906190 PMID:24136188 NCBI chr10:81,796,055...81,812,926
Ensembl chr10:81,800,366...81,832,318 		JBrowse link
G Nfib nuclear factor I/B multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of NFIB mRNA CTD PMID:20371263 NCBI chr 5:96,759,208...96,974,001
Ensembl chr 5:96,764,653...96,975,479 		JBrowse link
G Nfil3 nuclear factor, interleukin 3 regulated increases expression ISO Sulindac results in increased expression of NFIL3 mRNA CTD PMID:11906190 NCBI chr17:12,280,499...12,295,728
Ensembl chr17:12,280,484...12,295,858 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
decreases activity		 ISO Acetylcysteine inhibits the reaction [Sulindac analog results in decreased activity of NFKB1 protein]; Sulindac inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Sulindac inhibits the reaction [TNF protein results in increased activity of NFKB1 protein] CTD PMID:15489888 PMID:18922898 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
decreases phosphorylation		 ISO
EXP		 [[Sulindac co-treated with arsenic trioxide] results in decreased phosphorylation of and results in decreased degradation of NFKBIA protein] which affects the localization of RELA protein; [Sulindac co-treated with arsenic trioxide] results in decreased phosphorylation of and results in decreased degradation of NFKBIA protein; Sulindac inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Sulindac results in increased degradation of and results in decreased expression of NFKBIA protein
[Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of NFKBIA mRNA
Sulindac results in decreased phosphorylation of NFKBIA protein		 CTD PMID:11591705 PMID:15489888 PMID:18059344 PMID:18575716 PMID:20371263 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nfu1 NFU1 iron-sulfur cluster scaffold decreases expression EXP Sulindac results in decreased expression of NFU1 mRNA CTD PMID:24136188 NCBI chr 4:119,458,981...119,480,162
Ensembl chr 4:119,459,061...119,480,373 		JBrowse link
G Npc1 NPC intracellular cholesterol transporter 1 increases expression ISO Sulindac results in increased expression of NPC1 mRNA CTD PMID:11906190 NCBI chr18:3,379,482...3,425,100
Ensembl chr18:3,379,482...3,425,049 		JBrowse link
G Nphp1 nephrocystin 1 increases expression EXP Sulindac results in increased expression of NPHP1 mRNA CTD PMID:24136188 NCBI chr 3:114,960,650...115,016,234
Ensembl chr 3:114,960,650...115,016,234 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity
increases expression		 ISO Sulindac results in increased activity of NQO1 protein
Sulindac results in increased expression of NQO1 mRNA		 CTD PMID:11093808 PMID:17985343 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nsmf NMDA receptor synaptonuclear signaling and neuronal migration factor decreases expression EXP Sulindac results in decreased expression of NSMF mRNA CTD PMID:24136188 NCBI chr 3:7,861,846...7,870,615
Ensembl chr 3:7,861,872...7,870,614 		JBrowse link
G Nudt16l1 nudix hydrolase 16 like 1 increases expression EXP Sulindac results in increased expression of NUDT16L1 mRNA CTD PMID:24136188 NCBI chr10:10,636,174...10,638,090
Ensembl chr10:10,636,174...10,688,370 		JBrowse link
G Numb NUMB, endocytic adaptor protein increases expression EXP Sulindac results in increased expression of NUMB mRNA CTD PMID:24136188 NCBI chr 6:103,431,400...103,553,422
Ensembl chr 6:103,431,400...103,553,354 		JBrowse link
G Nup37 nucleoporin 37 increases expression EXP Sulindac results in increased expression of NUP37 mRNA CTD PMID:24136188 NCBI chr 7:22,556,544...22,609,622
Ensembl chr 7:22,573,764...22,609,616 		JBrowse link
G Nupr2 nuclear protein 2, transcriptional regulator increases expression EXP Sulindac results in increased expression of NUPR2 mRNA CTD PMID:24136188 NCBI chr12:26,800,123...26,803,228
Ensembl chr12:26,799,800...26,803,304 		JBrowse link
G Orc4 origin recognition complex, subunit 4 decreases expression ISO Sulindac results in decreased expression of ORC4 mRNA CTD PMID:11906190 NCBI chr 3:33,290,844...33,334,022
Ensembl chr 3:33,294,355...33,333,824 		JBrowse link
G Osbpl9 oxysterol binding protein-like 9 decreases expression EXP Sulindac results in decreased expression of OSBPL9 mRNA CTD PMID:24136188 NCBI chr 5:123,819,106...123,962,213
Ensembl chr 5:123,819,104...123,962,196 		JBrowse link
G Ostf1 osteoclast stimulating factor 1 increases expression ISO Sulindac results in increased expression of OSTF1 mRNA CTD PMID:11906190 NCBI chr 1:216,002,037...216,049,226
Ensembl chr 1:216,002,044...216,049,221 		JBrowse link
G Ostm1 osteoclastogenesis associated transmembrane protein 1 increases expression EXP Sulindac results in increased expression of OSTM1 mRNA CTD PMID:24136188 NCBI chr20:46,071,657...46,187,049
Ensembl chr20:46,153,075...46,187,023 		JBrowse link
G Otud1 OTU deubiquitinase 1 increases expression ISO Sulindac results in increased expression of OTUD1 mRNA CTD PMID:11906190 NCBI chr17:82,259,920...82,262,770
Ensembl chr17:82,259,840...82,262,995 		JBrowse link
G P4hb prolyl 4-hydroxylase subunit beta decreases expression ISO Sulindac results in decreased expression of P4HB mRNA CTD PMID:32535746 NCBI chr10:105,836,972...105,848,583
Ensembl chr10:105,836,982...105,848,500 		JBrowse link
G Pacsin3 protein kinase C and casein kinase substrate in neurons 3 increases expression EXP Sulindac results in increased expression of PACSIN3 mRNA CTD PMID:24136188 NCBI chr 3:77,227,187...77,235,820
Ensembl chr 3:77,222,710...77,235,811 		JBrowse link
G Pak6 p21 (RAC1) activated kinase 6 decreases expression EXP Sulindac results in decreased expression of PAK6 mRNA CTD PMID:24136188 NCBI chr 3:105,638,248...105,674,399
Ensembl chr 3:105,638,653...105,672,975 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases activity		 ISO [Sulindac co-treated with arsenic trioxide] results in increased cleavage of PARP1 protein; Acetylcysteine inhibits the reaction [[Sulindac co-treated with arsenic trioxide] results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [[Sulindac co-treated with arsenic trioxide] results in increased cleavage of PARP1 protein]; Sulindac promotes the reaction [Deferoxamine results in increased cleavage of PARP1 protein]
Sulindac results in increased activity of PARP1 protein		 CTD PMID:15713900 PMID:18281123 PMID:21882223 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Parp14 poly (ADP-ribose) polymerase family, member 14 decreases expression EXP Sulindac results in decreased expression of PARP14 mRNA CTD PMID:24136188 NCBI chr11:64,902,848...64,934,916
Ensembl chr11:64,902,785...64,934,916 		JBrowse link
G Pbrm1 polybromo 1 decreases expression EXP Sulindac results in decreased expression of PBRM1 mRNA CTD PMID:24136188 NCBI chr16:6,213,507...6,312,895
Ensembl chr16:6,213,300...6,311,780 		JBrowse link
G Pcbp1 poly(rC) binding protein 1 increases expression EXP Sulindac results in increased expression of PCBP1 mRNA CTD PMID:24136188 NCBI chr 4:118,972,698...118,974,705
Ensembl chr 4:118,972,661...118,976,500 		JBrowse link
G Pcdh17 protocadherin 17 decreases expression ISO Sulindac results in decreased expression of PCDH17 mRNA CTD PMID:11906190 NCBI chr15:60,222,088...60,316,172
Ensembl chr15:60,222,004...60,313,999 		JBrowse link
G Pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) increases expression ISO Sulindac results in increased expression of PCK2 mRNA CTD PMID:11906190 NCBI chr15:29,027,891...29,036,729
Ensembl chr15:29,027,894...29,037,283 		JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression
multiple interactions		 ISO
EXP		 Sulindac results in decreased expression of PCNA protein
epigallocatechin gallate promotes the reaction [Sulindac inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PCNA protein]]; kaempferol promotes the reaction [Sulindac inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PCNA protein]]; Sulindac inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PCNA protein]		 CTD PMID:15020200 PMID:29999212 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pdgfa platelet derived growth factor subunit A multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of PDGFA mRNA CTD PMID:20371263 NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497 		JBrowse link
G Pdlim7 PDZ and LIM domain 7 increases expression ISO Sulindac results in increased expression of PDLIM7 mRNA CTD PMID:11906190 NCBI chr17:9,124,565...9,139,814
Ensembl chr17:9,124,649...9,139,811 		JBrowse link
G Per1 period circadian regulator 1 decreases expression EXP Sulindac results in decreased expression of PER1 mRNA CTD PMID:24136188 NCBI chr10:53,800,126...53,814,963
Ensembl chr10:53,805,535...53,814,431 		JBrowse link
G Pex2 peroxisomal biogenesis factor 2 increases expression EXP Sulindac results in increased expression of PEX2 mRNA CTD PMID:24136188 NCBI chr 2:96,050,380...96,072,928
Ensembl chr 2:96,045,958...96,073,404 		JBrowse link
G Pfdn6 prefoldin subunit 6 increases expression EXP Sulindac results in increased expression of PFDN6 mRNA CTD PMID:24136188 NCBI chr20:4,945,959...4,947,433
Ensembl chr20:4,945,959...4,947,433 		JBrowse link
G Pgap2 post-GPI attachment to proteins 2 decreases expression EXP Sulindac results in decreased expression of PGAP2 mRNA CTD PMID:24136188 NCBI chr 1:156,591,540...156,618,116
Ensembl chr 1:156,591,615...156,618,114 		JBrowse link
G Pi4k2b phosphatidylinositol 4-kinase type 2 beta increases expression EXP Sulindac results in increased expression of PI4K2B mRNA CTD PMID:24136188 NCBI chr14:58,221,790...58,248,716
Ensembl chr14:58,220,437...58,248,673 		JBrowse link
G Pi4ka phosphatidylinositol 4-kinase alpha increases expression EXP Sulindac results in increased expression of PI4KA mRNA CTD PMID:24136188 NCBI chr11:83,609,148...83,726,876
Ensembl chr11:83,609,069...83,724,080 		JBrowse link
G Pigc phosphatidylinositol glycan anchor biosynthesis, class C increases expression EXP Sulindac results in increased expression of PIGC mRNA CTD PMID:24136188 NCBI chr13:74,343,619...74,346,148
Ensembl chr13:74,296,854...74,346,211 		JBrowse link
G Pigy phosphatidylinositol glycan anchor biosynthesis, class Y increases expression EXP Sulindac results in increased expression of PIGY mRNA CTD PMID:24136188 NCBI chr 8:20,689,621...20,691,863
Ensembl chr 8:20,689,502...20,692,585 		JBrowse link
G Pisd phosphatidylserine decarboxylase decreases expression EXP Sulindac results in decreased expression of PISD mRNA CTD PMID:24136188 NCBI chr14:77,941,927...77,991,021
Ensembl chr14:77,941,948...77,991,003 		JBrowse link
G Pithd1 PITH domain containing 1 increases expression EXP Sulindac results in increased expression of PITHD1 mRNA CTD PMID:24136188 NCBI chr 5:148,205,995...148,216,490
Ensembl chr 5:148,205,998...148,217,080 		JBrowse link
G Pkd1 polycystin 1, transient receptor potential channel interacting increases expression ISO Sulindac results in increased expression of PKD1 mRNA CTD PMID:11906190 NCBI chr10:13,573,779...13,621,138
Ensembl chr10:13,573,021...13,621,128 		JBrowse link
G Pla2g4a phospholipase A2 group 4A multiple interactions
decreases expression		 ISO Sulindac inhibits the reaction [PLA2G4A gene mutant form results in decreased expression of SOD1 protein]
Sulindac results in decreased expression of PLA2G4A mRNA		 CTD PMID:10706128 PMID:15816863 NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266 		JBrowse link
G Plat plasminogen activator, tissue type multiple interactions ISO [Sulindac co-treated with epigallocatechin gallate] results in decreased expression of PLAT mRNA CTD PMID:12628509 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223 		JBrowse link
G Plcg1 phospholipase C, gamma 1 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of PLCG1 mRNA CTD PMID:20371263 NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330 		JBrowse link
G Plec plectin increases expression EXP Sulindac results in increased expression of PLEC mRNA CTD PMID:24136188 NCBI chr 7:107,887,764...107,949,100
Ensembl chr 7:107,887,764...107,945,467 		JBrowse link
G Plekhb2 pleckstrin homology domain containing B2 decreases expression EXP Sulindac results in decreased expression of PLEKHB2 mRNA CTD PMID:24136188 NCBI chr 9:37,049,580...37,082,231
Ensembl chr 9:37,038,751...37,082,231 		JBrowse link
G Plekhf1 pleckstrin homology and FYVE domain containing 1 increases expression ISO Sulindac results in increased expression of PLEKHF1 mRNA CTD PMID:11906190 NCBI chr 1:90,908,304...90,915,862
Ensembl chr 1:90,904,742...90,915,820 		JBrowse link
G Plxna3 plexin A3 increases expression ISO Sulindac results in increased expression of PLXNA3 mRNA CTD PMID:11906190 NCBI chr  X:152,115,699...152,131,608
Ensembl chr  X:152,115,819...152,131,603 		JBrowse link
G Pml PML nuclear body scaffold increases expression ISO Sulindac results in increased expression of PML mRNA CTD PMID:16273229 NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971 		JBrowse link
G Pole4 DNA polymerase epsilon 4, accessory subunit decreases expression EXP Sulindac results in decreased expression of POLE4 mRNA CTD PMID:24136188 NCBI chr 4:115,165,285...115,171,097
Ensembl chr 4:115,165,285...115,171,097 		JBrowse link
G Polr2c RNA polymerase II subunit C decreases expression EXP Sulindac results in decreased expression of POLR2C mRNA CTD PMID:24136188 NCBI chr19:10,158,153...10,164,935
Ensembl chr19:10,157,823...10,164,945 		JBrowse link
G Pomp proteasome maturation protein decreases expression EXP Sulindac results in decreased expression of POMP mRNA CTD PMID:24136188 NCBI chr12:7,162,098...7,174,737
Ensembl chr12:7,160,714...7,174,715 		JBrowse link
G Pon3 paraoxonase 3 decreases expression EXP Sulindac results in decreased expression of PON3 mRNA CTD PMID:24136188 NCBI chr 4:33,356,983...33,383,681
Ensembl chr 4:33,349,168...33,383,855 		JBrowse link
G Ppard peroxisome proliferator-activated receptor delta increases expression
affects response to substance		 ISO Sulindac results in increased expression of PPARD protein
PPARD protein affects the susceptibility to Sulindac		 CTD PMID:10866668 PMID:21400612 NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968 		JBrowse link
G Ppp2cb protein phosphatase 2 catalytic subunit beta increases expression EXP Sulindac results in increased expression of PPP2CB mRNA CTD PMID:24136188 NCBI chr16:58,558,119...58,579,325
Ensembl chr16:58,558,122...58,579,576 		JBrowse link
G Ppp6r1 protein phosphatase 6, regulatory subunit 1 decreases expression EXP Sulindac results in decreased expression of PPP6R1 mRNA CTD PMID:24136188 NCBI chr 1:69,190,856...69,217,598
Ensembl chr 1:69,189,822...69,216,272 		JBrowse link
G Ppt1 palmitoyl-protein thioesterase 1 decreases expression EXP Sulindac results in decreased expression of PPT1 mRNA CTD PMID:24136188 NCBI chr 5:135,121,164...135,142,048
Ensembl chr 5:135,121,163...135,142,048 		JBrowse link
G Prdm15 PR/SET domain 15 increases expression EXP Sulindac results in increased expression of PRDM15 mRNA CTD PMID:24136188 NCBI chr11:37,164,608...37,225,172
Ensembl chr11:37,165,575...37,222,207 		JBrowse link
G Prdx1 peroxiredoxin 1 increases expression EXP Sulindac results in increased expression of PRDX1 mRNA CTD PMID:24136188 NCBI chr 5:130,147,258...130,162,856
Ensembl chr 5:130,147,204...130,162,856 		JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of PRKAA2 mRNA CTD PMID:20371263 NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543 		JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of PRKACA mRNA CTD PMID:20371263 NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430 		JBrowse link
G Prkacb protein kinase cAMP-activated catalytic subunit beta multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of PRKACB mRNA CTD PMID:20371263 NCBI chr 2:235,636,878...235,726,928
Ensembl chr 2:235,636,885...235,726,198 		JBrowse link
G Prkci protein kinase C, iota increases expression EXP Sulindac results in increased expression of PRKCI mRNA CTD PMID:24136188 NCBI chr 2:112,321,919...112,382,305
Ensembl chr 2:112,321,929...112,382,352 		JBrowse link
G Prodh proline dehydrogenase decreases expression EXP Sulindac results in decreased expression of PRODH mRNA CTD PMID:24136188 NCBI chr11:82,910,043...82,927,305
Ensembl chr11:82,910,137...82,927,305 		JBrowse link
G Prorp protein only RNase P catalytic subunit increases expression EXP Sulindac results in increased expression of PRORP mRNA CTD PMID:24136188 NCBI chr 6:72,669,659...72,762,419
Ensembl chr 6:72,670,847...72,762,416 		JBrowse link
G Psma5 proteasome 20S subunit alpha 5 decreases expression EXP Sulindac results in decreased expression of PSMA5 mRNA CTD PMID:24136188 NCBI chr 2:195,896,369...195,919,733
Ensembl chr 2:195,896,365...195,919,731 		JBrowse link
G Psmb5 proteasome 20S subunit beta 5 increases expression EXP Sulindac results in increased expression of PSMB5 mRNA CTD PMID:24136188 NCBI chr15:28,072,772...28,077,367
Ensembl chr15:28,072,781...28,077,440 		JBrowse link
G Psmc2 proteasome 26S subunit, ATPase 2 increases expression EXP Sulindac results in increased expression of PSMC2 mRNA CTD PMID:24136188 NCBI chr 4:13,255,850...13,270,160
Ensembl chr 4:13,255,856...13,270,185 		JBrowse link
G Psmc5 proteasome 26S subunit, ATPase 5 decreases expression EXP Sulindac results in decreased expression of PSMC5 mRNA CTD PMID:24136188 NCBI chr10:91,187,763...91,193,697
Ensembl chr10:91,187,743...91,213,135 		JBrowse link
G Psmc6 proteasome 26S subunit, ATPase 6 increases expression EXP Sulindac results in increased expression of PSMC6 mRNA CTD PMID:24136188 NCBI chr15:18,542,585...18,564,057
Ensembl chr15:18,542,563...18,564,055 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases expression
increases expression		 EXP Sulindac results in decreased expression of PTGS1 mRNA alternative form
Sulindac results in increased expression of PTGS1 mRNA		 CTD PMID:11375891 PMID:12586211 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
decreases expression
decreases activity		 ISO
EXP		 [Sulindac co-treated with Deferoxamine] results in increased expression of PTGS2 protein; Sulindac inhibits the reaction [Mitomycin results in increased expression of PTGS2 protein]; Sulindac inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; Sulindac promotes the reaction [cobaltous chloride results in increased expression of PTGS2 protein]
Sulindac results in increased expression of PTGS2 mRNA
Sulindac results in decreased expression of PTGS2 mRNA
Sulindac results in decreased activity of PTGS2 protein
[Olive Oil co-treated with Sulindac] results in decreased expression of PTGS2 protein; epigallocatechin gallate promotes the reaction [Sulindac inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PTGS2 protein]]; Sulindac inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PTGS2 protein]
Sulindac results in decreased expression of PTGS2 protein		 CTD PMID:10706128 PMID:11375891 PMID:11504793 PMID:11910360 PMID:12586211 More... NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ptp4a2 protein tyrosine phosphatase 4A2 increases expression EXP Sulindac results in increased expression of PTP4A2 mRNA CTD PMID:24136188 NCBI chr 5:142,165,405...142,192,412
Ensembl chr 5:142,165,700...142,191,899 		JBrowse link
G Ptprn protein tyrosine phosphatase, receptor type, N decreases expression EXP Sulindac results in decreased expression of PTPRN mRNA CTD PMID:24136188 NCBI chr 9:76,741,010...76,756,704
Ensembl chr 9:76,741,016...76,756,190 		JBrowse link
G Pus10 pseudouridine synthase 10 increases expression EXP Sulindac results in increased expression of PUS10 mRNA CTD PMID:24136188 NCBI chr14:97,621,228...97,684,059
Ensembl chr14:97,621,391...97,684,046 		JBrowse link
G Qtrt1 queuine tRNA-ribosyltransferase catalytic subunit 1 decreases expression EXP Sulindac results in decreased expression of QTRT1 mRNA CTD PMID:24136188 NCBI chr 8:19,965,801...19,973,843
Ensembl chr 8:19,966,336...19,973,837 		JBrowse link
G Rab28 RAB28, member RAS oncogene family increases expression EXP Sulindac results in increased expression of RAB28 mRNA CTD PMID:24136188 NCBI chr14:69,245,846...69,322,968
Ensembl chr14:69,245,854...69,322,967 		JBrowse link
G Rab2b RAB2B, member RAS oncogene family increases expression EXP Sulindac results in increased expression of RAB2B mRNA CTD PMID:24136188 NCBI chr15:24,968,364...24,988,990
Ensembl chr15:24,968,803...24,989,113 		JBrowse link
G Rac2 Rac family small GTPase 2 decreases expression EXP Sulindac results in decreased expression of RAC2 mRNA CTD PMID:24136188 NCBI chr 7:110,101,344...110,128,718
Ensembl chr 7:110,116,260...110,128,720 		JBrowse link
G Ramac RNA guanine-7 methyltransferase activating subunit decreases expression EXP Sulindac results in decreased expression of RAMAC mRNA CTD PMID:24136188 NCBI chr 1:135,708,529...135,714,417
Ensembl chr 1:135,708,535...135,722,151 		JBrowse link
G Rasa1 RAS p21 protein activator 1 decreases expression EXP Sulindac results in decreased expression of RASA1 mRNA CTD PMID:24136188 NCBI chr 2:15,857,704...15,940,757
Ensembl chr 2:15,857,980...15,940,854 		JBrowse link
G Rassf6 Ras association domain family member 6 increases expression EXP Sulindac results in increased expression of RASSF6 mRNA CTD PMID:24136188 NCBI chr14:17,433,328...17,473,565
Ensembl chr14:17,442,789...17,473,330 		JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases expression ISO Sulindac results in decreased expression of RB1 protein CTD PMID:16488075 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Rbbp7 RB binding protein 7, chromatin remodeling factor increases expression EXP Sulindac results in increased expression of RBBP7 mRNA CTD PMID:24136188 NCBI chr  X:31,913,080...31,931,245
Ensembl chr  X:31,913,081...31,931,226 		JBrowse link
G Rbm42 RNA binding motif protein 42 decreases expression EXP Sulindac results in decreased expression of RBM42 mRNA CTD PMID:24136188 NCBI chr 1:85,898,618...85,908,569
Ensembl chr 1:85,898,625...85,908,573 		JBrowse link
G Rbm45 RNA binding motif protein 45 increases expression EXP Sulindac results in increased expression of RBM45 mRNA CTD PMID:24136188 NCBI chr 3:61,305,973...61,320,950
Ensembl chr 3:61,305,924...61,320,952 		JBrowse link
G Rbm47 RNA binding motif protein 47 decreases expression EXP Sulindac results in decreased expression of RBM47 mRNA CTD PMID:24136188 NCBI chr14:42,053,290...42,191,572
Ensembl chr14:42,154,142...42,189,431 		JBrowse link
G Rbx1 ring-box 1 increases expression EXP Sulindac results in increased expression of RBX1 mRNA CTD PMID:24136188 NCBI chr 7:112,976,863...113,001,051
Ensembl chr 7:112,990,835...113,001,051 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects localization
increases activity
increases expression
multiple interactions		 ISO Sulindac affects the localization of RELA protein
Sulindac results in increased activity of RELA protein
Sulindac results in increased expression of RELA mRNA
[[Sulindac co-treated with Arsenic Trioxide] results in decreased phosphorylation of and results in decreased degradation of NFKBIA protein] which affects the localization of RELA protein; Sulindac inhibits the reaction [Lipopolysaccharides results in increased expression of RELA protein]; Sulindac inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Sulindac inhibits the reaction [TNF protein results in increased activity of RELA protein]		 CTD PMID:10328874 PMID:15489888 PMID:16159934 PMID:16273229 PMID:18059344 More... NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Ren renin multiple interactions
decreases activity		 ISO Sulindac inhibits the reaction [Furosemide results in increased expression of REN protein]
Sulindac results in decreased activity of REN protein		 CTD PMID:2203262 PMID:3884224 PMID:4028619 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
G Ret ret proto-oncogene affects expression ISO Sulindac affects the expression of RET protein CTD PMID:12388792 NCBI chr 4:151,325,969...151,368,176
Ensembl chr 4:151,326,431...151,368,176 		JBrowse link
G RGD1311745 similar to RIKEN cDNA 1110059G10 increases expression EXP Sulindac results in increased expression of RGD1311745 mRNA CTD PMID:24136188 NCBI chr 8:122,598,363...122,609,127
Ensembl chr 8:122,598,401...122,609,168 		JBrowse link
G Rgp1 RGP1 homolog, RAB6A GEF complex partner 1 increases expression EXP Sulindac results in increased expression of RGP1 mRNA CTD PMID:24136188 NCBI chr 5:57,834,467...57,843,087
Ensembl chr 5:57,834,629...57,843,086 		JBrowse link
G Rmdn3 regulator of microtubule dynamics 3 decreases expression EXP Sulindac results in decreased expression of RMDN3 mRNA CTD PMID:24136188 NCBI chr 3:106,125,961...106,146,568
Ensembl chr 3:106,125,951...106,146,586 		JBrowse link
G Rnase1 ribonuclease A family member 1, pancreatic decreases expression ISO Sulindac results in decreased expression of RNASE1 mRNA CTD PMID:11906190 NCBI chr15:24,361,924...24,363,633
Ensembl chr15:24,361,927...24,363,624 		JBrowse link
G Rnf220 ring finger protein 220 increases expression EXP Sulindac results in increased expression of RNF220 mRNA CTD PMID:24136188 NCBI chr 5:130,739,173...130,961,386
Ensembl chr 5:130,739,183...130,961,418 		JBrowse link
G Rnf26 ring finger protein 26 decreases expression ISO Sulindac results in decreased expression of RNF26 mRNA CTD PMID:11906190 NCBI chr 8:44,454,551...44,456,745
Ensembl chr 8:44,454,292...44,457,331 		JBrowse link
G Rnpepl1 arginyl aminopeptidase like 1 decreases expression EXP Sulindac results in decreased expression of RNPEPL1 mRNA CTD PMID:24136188 NCBI chr 9:93,476,600...93,486,331
Ensembl chr 9:93,472,390...93,486,331 		JBrowse link
G Rpia ribose 5-phosphate isomerase A decreases expression EXP Sulindac results in decreased expression of RPIA mRNA CTD PMID:24136188 NCBI chr 4:102,723,712...102,749,374
Ensembl chr 4:102,723,712...102,749,355 		JBrowse link
G Rragc Ras-related GTP binding C decreases expression EXP Sulindac results in decreased expression of RRAGC mRNA CTD PMID:24136188 NCBI chr 5:136,148,239...136,167,773
Ensembl chr 5:136,148,276...136,167,767 		JBrowse link
G Rxra retinoid X receptor alpha multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of RXRA mRNA CTD PMID:20371263 NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712 		JBrowse link
G Sae1 SUMO1 activating enzyme subunit 1 decreases expression EXP Sulindac results in decreased expression of SAE1 mRNA CTD PMID:24136188 NCBI chr 1:77,030,961...77,086,937
Ensembl chr 1:77,030,965...77,086,986 		JBrowse link
G Sap30l SAP30-like decreases expression EXP Sulindac results in decreased expression of SAP30L mRNA CTD PMID:24136188 NCBI chr10:41,979,730...41,992,307
Ensembl chr10:41,979,687...41,987,658 		JBrowse link
G Sat1 spermidine/spermine N1-acetyl transferase 1 increases expression ISO Sulindac results in increased expression of SAT1 mRNA CTD PMID:14506281 PMID:16262603 NCBI chr  X:40,158,354...40,161,641
Ensembl chr  X:40,157,046...40,196,813 		JBrowse link
G Sat2 spermidine/spermine N1-acetyltransferase family member 2 increases activity
increases expression		 ISO Sulindac results in increased activity of SAT2 protein
Sulindac results in increased expression of SAT2 mRNA		 CTD PMID:17474863 NCBI chr10:54,340,756...54,343,507
Ensembl chr10:54,340,372...54,343,224 		JBrowse link
G Scamp1 secretory carrier membrane protein 1 increases expression EXP Sulindac results in increased expression of SCAMP1 mRNA CTD PMID:24136188 NCBI chr 2:25,433,958...25,516,734
Ensembl chr 2:25,433,959...25,516,673 		JBrowse link
G Sco1 synthesis of cytochrome C oxidase 1 increases expression EXP Sulindac results in increased expression of SCO1 mRNA CTD PMID:24136188 NCBI chr10:51,744,656...51,757,246
Ensembl chr10:51,744,656...51,757,237 		JBrowse link
G Sdhaf3 succinate dehydrogenase complex assembly factor 3 increases expression EXP Sulindac results in increased expression of SDHAF3 mRNA CTD PMID:24136188 NCBI chr 4:35,100,533...35,160,740
Ensembl chr 4:35,100,506...35,160,749 		JBrowse link
G Sec62 SEC62 homolog, preprotein translocation factor decreases expression EXP Sulindac results in decreased expression of SEC62 mRNA CTD PMID:24136188 NCBI chr 2:112,570,810...112,598,198
Ensembl chr 2:112,570,819...112,601,814 		JBrowse link
G Sec63 SEC63 homolog, protein translocation regulator decreases expression EXP Sulindac results in decreased expression of SEC63 mRNA CTD PMID:24136188 NCBI chr20:46,245,101...46,314,055
Ensembl chr20:46,245,101...46,314,055 		JBrowse link
G Septin10 septin 10 decreases expression EXP Sulindac results in decreased expression of SEPTIN10 mRNA CTD PMID:24136188 NCBI chr20:27,101,764...27,194,997
Ensembl chr20:27,101,752...27,194,780 		JBrowse link
G Serpinb1a serpin family B member 1A increases expression ISO Sulindac results in increased expression of SERPINB1 mRNA CTD PMID:11507085 NCBI chr17:31,590,695...31,599,102
Ensembl chr17:31,590,677...31,599,102 		JBrowse link
G Set Set nuclear proto-oncogene decreases expression EXP Sulindac results in decreased expression of SET mRNA CTD PMID:24136188 NCBI chr 3:13,334,564...13,345,598
Ensembl chr 3:13,335,041...13,363,567 		JBrowse link
G Sft2d2 SFT2 domain containing 2 increases expression EXP Sulindac results in increased expression of SFT2D2 mRNA CTD PMID:24136188 NCBI chr13:77,484,778...77,504,123
Ensembl chr13:77,484,636...77,504,112 		JBrowse link
G Shc1 SHC adaptor protein 1 multiple interactions ISO Sulindac inhibits the reaction [CDKN1A protein results in increased expression of SHC1 mRNA] CTD PMID:15190207 NCBI chr 2:174,837,937...174,849,538
Ensembl chr 2:174,837,930...174,849,536 		JBrowse link
G Shmt2 serine hydroxymethyltransferase 2 increases expression EXP Sulindac results in increased expression of SHMT2 mRNA CTD PMID:24136188 NCBI chr 7:63,358,961...63,364,293
Ensembl chr 7:63,358,961...63,364,236 		JBrowse link
G Sirt1 sirtuin 1 increases expression ISO Sulindac results in increased expression of SIRT1 mRNA CTD PMID:11906190 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Skic8 SKI8 subunit of superkiller complex decreases expression EXP Sulindac results in decreased expression of SKIC8 mRNA CTD PMID:24136188 NCBI chr 8:55,103,542...55,120,837
Ensembl chr 8:55,103,545...55,120,813 		JBrowse link
G Slc16a6 solute carrier family 16, member 6 increases expression ISO Sulindac results in increased expression of SLC16A6 mRNA CTD PMID:11906190 NCBI chr10:94,424,377...94,447,482
Ensembl chr10:94,426,244...94,448,779 		JBrowse link
G Slc18b1 solute carrier family 18 member B1 increases expression EXP Sulindac results in increased expression of SLC18B1 mRNA CTD PMID:24136188 NCBI chr 1:21,628,235...21,670,807
Ensembl chr 1:21,628,237...21,670,684 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 decreases activity ISO Sulindac results in decreased activity of SLC22A1 protein CTD PMID:12388633 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 decreases activity ISO Sulindac results in decreased activity of SLC22A2 protein CTD PMID:12388633 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Slc22a25 solute carrier family 22, member 25 decreases activity ISO Sulindac results in decreased activity of SLC22A9 protein CTD PMID:12388633 NCBI chr 1:205,338,698...205,498,486
Ensembl chr 1:205,338,699...205,433,085 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 decreases activity ISO Sulindac results in decreased activity of SLC22A6 protein CTD PMID:12388633 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173 		JBrowse link
G Slc22a7 solute carrier family 22 member 7 decreases activity ISO Sulindac results in decreased activity of SLC22A7 protein CTD PMID:12388633 NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921 		JBrowse link
G Slc27a4 solute carrier family 27 member 4 decreases expression EXP Sulindac results in decreased expression of SLC27A4 mRNA CTD PMID:24136188 NCBI chr 3:13,075,022...13,087,943
Ensembl chr 3:13,075,022...13,087,943 		JBrowse link
G Slc30a1 solute carrier family 30 member 1 increases expression ISO Sulindac results in increased expression of SLC30A1 mRNA CTD PMID:11906190 NCBI chr13:103,491,037...103,494,910
Ensembl chr13:103,491,037...103,494,910 		JBrowse link
G Slc30a5 solute carrier family 30 member 5 decreases expression EXP Sulindac results in decreased expression of SLC30A5 mRNA CTD PMID:24136188 NCBI chr 2:31,945,745...31,975,969
Ensembl chr 2:31,945,729...31,975,934 		JBrowse link
G Slc38a2 solute carrier family 38, member 2 increases expression ISO Sulindac results in increased expression of SLC38A2 mRNA CTD PMID:11906190 NCBI chr 7:127,851,267...127,863,482
Ensembl chr 7:127,851,267...127,863,436 		JBrowse link
G Slc3a2 solute carrier family 3 member 2 increases expression ISO Sulindac results in increased expression of SLC3A2 mRNA CTD PMID:11906190 NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931 		JBrowse link
G Slc4a1ap solute carrier family 4 member 1 adaptor protein decreases expression EXP Sulindac results in decreased expression of SLC4A1AP mRNA CTD PMID:24136188 NCBI chr 6:24,905,941...24,933,651
Ensembl chr 6:24,905,941...24,933,815 		JBrowse link
G Slc7a1 solute carrier family 7 member 1 increases expression ISO Sulindac results in increased expression of SLC7A1 mRNA CTD PMID:11906190 NCBI chr12:6,628,288...6,703,849
Ensembl chr12:6,628,007...6,703,849 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of SLCO1A2 mRNA CTD PMID:20371263 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573 		JBrowse link
G Slfn3 schlafen family member 3 decreases expression EXP Sulindac results in decreased expression of SLFN3 mRNA CTD PMID:24136188 NCBI chr10:68,020,482...68,060,248 JBrowse link
G Smc1a structural maintenance of chromosomes 1A decreases expression EXP Sulindac results in decreased expression of SMC1A mRNA CTD PMID:24136188 NCBI chr  X:21,103,323...21,148,053
Ensembl chr  X:21,103,282...21,148,056 		JBrowse link
G Smu1 SMU1, DNA replication regulator and spliceosomal factor decreases expression EXP Sulindac results in decreased expression of SMU1 mRNA CTD PMID:24136188 NCBI chr 5:55,856,691...55,875,262
Ensembl chr 5:55,856,246...55,875,300 		JBrowse link
G Snrnp27 small nuclear ribonucleoprotein U4/U6.U5 subunit 27 increases expression EXP Sulindac results in increased expression of SNRNP27 mRNA CTD PMID:24136188 NCBI chr 4:119,123,676...119,133,234
Ensembl chr 4:119,121,877...119,133,234 		JBrowse link
G Snx21 sorting nexin family member 21 increases expression ISO Sulindac results in increased expression of SNX21 mRNA CTD PMID:11906190 NCBI chr 3:153,522,474...153,532,235
Ensembl chr 3:153,522,486...153,532,221 		JBrowse link
G Snx25 sorting nexin 25 increases expression ISO Sulindac results in increased expression of SNX25 mRNA CTD PMID:11906190 NCBI chr16:46,134,552...46,238,471
Ensembl chr16:46,125,804...46,238,440 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO Sulindac inhibits the reaction [PLA2G4A gene mutant form results in decreased expression of SOD1 protein] CTD PMID:15816863 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO Sulindac inhibits the reaction [CDKN1A protein results in increased expression of SOD2 mRNA] CTD PMID:15190207 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Spred3 sprouty-related, EVH1 domain containing 3 decreases expression EXP Sulindac results in decreased expression of SPRED3 mRNA CTD PMID:24136188 NCBI chr 1:84,458,779...84,470,425
Ensembl chr 1:84,459,314...84,470,249 		JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO Sulindac results in increased expression of SQSTM1 mRNA CTD PMID:11906190 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions EXP
ISO		 [[Azoxymethane co-treated with Sulindac] results in increased expression of CSK protein] which results in increased phosphorylation of and results in decreased activity of SRC protein
Sulindac results in increased phosphorylation of and results in decreased activity of SRC protein		 CTD PMID:18644992 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO Sulindac results in increased expression of SRXN1 protein CTD PMID:27358234 NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448 		JBrowse link
G Ss18 SS18 subunit of BAF chromatin remodeling complex decreases expression EXP Sulindac results in decreased expression of SS18 mRNA CTD PMID:24136188 NCBI chr18:5,773,042...5,835,696
Ensembl chr18:5,773,042...5,835,333 		JBrowse link
G Ssu72 SSU72 homolog, RNA polymerase II CTD phosphatase decreases expression EXP Sulindac results in decreased expression of SSU72 mRNA CTD PMID:24136188 NCBI chr 5:166,312,267...166,343,432
Ensembl chr 5:166,313,650...166,343,429 		JBrowse link
G Stac3 SH3 and cysteine rich domain 3 decreases expression EXP Sulindac results in decreased expression of STAC3 mRNA CTD PMID:24136188 NCBI chr 7:63,343,078...63,350,590
Ensembl chr 7:63,343,186...63,350,589 		JBrowse link
G Stard3 StAR-related lipid transfer domain containing 3 increases expression EXP Sulindac results in increased expression of STARD3 mRNA CTD PMID:24136188 NCBI chr10:83,357,329...83,379,873
Ensembl chr10:83,357,359...83,550,976 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
decreases expression
decreases phosphorylation		 ISO BIRC5 protein inhibits the reaction [Sulindac results in decreased expression of STAT3 protein modified form]; BIRC5 protein inhibits the reaction [Sulindac results in decreased expression of STAT3 protein]
Sulindac results in decreased expression of STAT3 protein; Sulindac results in decreased expression of STAT3 protein modified form
Sulindac results in decreased phosphorylation of STAT3 protein		 CTD PMID:11861373 PMID:17401459 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Stc2 stanniocalcin 2 increases expression ISO Sulindac results in increased expression of STC2 mRNA CTD PMID:11906190 NCBI chr10:16,251,046...16,260,815
Ensembl chr10:16,250,853...16,262,973 		JBrowse link
G Stoml2 stomatin like 2 increases expression EXP Sulindac results in increased expression of STOML2 mRNA CTD PMID:24136188 NCBI chr 5:57,256,227...57,259,824
Ensembl chr 5:57,256,220...57,259,920 		JBrowse link
G Strbp spermatid perinuclear RNA binding protein increases expression EXP Sulindac results in increased expression of STRBP mRNA CTD PMID:24136188 NCBI chr 3:21,328,310...21,467,753
Ensembl chr 3:21,337,855...21,414,949 		JBrowse link
G Stx7 syntaxin 7 decreases expression EXP Sulindac results in decreased expression of STX7 mRNA CTD PMID:24136188 NCBI chr 1:21,197,075...21,237,320
Ensembl chr 1:21,197,075...21,237,279 		JBrowse link
G Stxbp2 syntaxin binding protein 2 increases expression ISO Sulindac results in increased expression of STXBP2 mRNA CTD PMID:11906190 NCBI chr12:1,689,364...1,701,145
Ensembl chr12:1,689,410...1,700,458 		JBrowse link
G Suclg1 succinate-CoA ligase GDP/ADP-forming subunit alpha increases expression EXP Sulindac results in increased expression of SUCLG1 mRNA CTD PMID:24136188 NCBI chr 4:105,308,236...105,337,595
Ensembl chr 4:105,308,039...105,337,600 		JBrowse link
G Sult1b1 sulfotransferase family 1B member 1 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of SULT1B1 mRNA CTD PMID:20371263 NCBI chr14:20,492,763...20,505,491
Ensembl chr14:20,492,708...20,505,483 		JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 multiple interactions
decreases activity		 EXP
ISO		 [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of SULT1E1 mRNA
Sulindac results in decreased activity of SULT1E1 protein		 CTD PMID:17073578 PMID:20371263 NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275 		JBrowse link
G Sumo3 small ubiquitin-like modifier 3 decreases expression ISO Sulindac results in decreased expression of SUMO3 mRNA CTD PMID:11906190 NCBI chr20:11,010,140...11,020,850
Ensembl chr20:11,007,148...11,020,877
Ensembl chr20:11,007,148...11,020,877 		JBrowse link
G Sun2 Sad1 and UNC84 domain containing 2 decreases expression ISO Sulindac results in decreased expression of SUN2 mRNA CTD PMID:11906190 NCBI chr 7:111,275,374...111,292,565
Ensembl chr 7:111,275,380...111,292,553 		JBrowse link
G Supt7l SPT7 like, STAGA complex subunit gamma decreases expression EXP Sulindac results in decreased expression of SUPT7L mRNA CTD PMID:24136188 NCBI chr 6:24,933,941...24,944,656
Ensembl chr 6:24,933,923...24,944,654 		JBrowse link
G Syp synaptophysin decreases expression EXP Sulindac results in decreased expression of SYP mRNA CTD PMID:24136188 NCBI chr  X:14,849,444...14,864,553
Ensembl chr  X:14,849,444...14,864,745 		JBrowse link
G Syt15 synaptotagmin 15 decreases expression EXP Sulindac results in decreased expression of SYT15 mRNA CTD PMID:24136188 NCBI chr16:9,532,478...9,543,288
Ensembl chr16:9,532,478...9,543,281 		JBrowse link
G Tbc1d10b TBC1 domain family, member 10b increases expression ISO Sulindac results in increased expression of TBC1D10B mRNA CTD PMID:11906190 NCBI chr 1:181,814,972...181,826,628
Ensembl chr 1:181,814,972...181,826,628 		JBrowse link
G Tbk1 TANK-binding kinase 1 increases expression ISO Sulindac results in increased expression of TBK1 mRNA CTD PMID:11093808 NCBI chr 7:57,077,830...57,110,868
Ensembl chr 7:57,077,830...57,110,892 		JBrowse link
G Tbx3 T-box transcription factor 3 increases expression ISO Sulindac results in increased expression of TBX3 mRNA CTD PMID:11906190 NCBI chr12:36,879,924...36,894,849
Ensembl chr12:36,881,445...36,893,708 		JBrowse link
G Tceanc2 transcription elongation factor A N-terminal and central domain containing 2 increases expression EXP Sulindac results in increased expression of TCEANC2 mRNA CTD PMID:24136188 NCBI chr 5:121,923,959...121,963,018
Ensembl chr 5:121,923,956...121,962,183 		JBrowse link
G Tcf4 transcription factor 4 decreases activity
multiple interactions		 ISO Sulindac results in decreased activity of TCF4 protein
TCF4 protein promotes the reaction [Sulindac results in increased susceptibility to TNFSF10 protein]		 CTD PMID:11593435 PMID:21171083 NCBI chr18:62,941,739...63,288,126
Ensembl chr18:62,943,782...63,284,425 		JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase decreases activity
multiple interactions		 EXP Sulindac results in decreased activity of TDO2 protein
[Sulindac results in decreased activity of TDO2 protein] which results in decreased abundance of Dopamine; [Sulindac results in decreased activity of TDO2 protein] which results in increased abundance of Serotonin		 CTD PMID:16952380 NCBI chr 2:167,269,581...167,287,511
Ensembl chr 2:167,269,579...167,287,511 		JBrowse link
G Tek TEK receptor tyrosine kinase multiple interactions ISO Sulindac analog results in decreased phosphorylation of and results in decreased activity of TEK protein CTD PMID:16215210 NCBI chr 5:109,607,077...109,733,805
Ensembl chr 5:109,607,077...109,733,804 		JBrowse link
G Tfdp1 transcription factor Dp-1 decreases expression EXP Sulindac results in decreased expression of TFDP1 mRNA CTD PMID:24136188 NCBI chr16:76,162,040...76,200,871
Ensembl chr16:76,162,043...76,200,817 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression ISO Sulindac results in increased expression of TGFB1 protein CTD PMID:11496082 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tgm2 transglutaminase 2 multiple interactions ISO Sulindac inhibits the reaction [CDKN1A protein results in increased expression of TGM2 mRNA] CTD PMID:15190207 NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981 		JBrowse link
G Thap7 THAP domain containing 7 increases expression EXP Sulindac results in increased expression of THAP7 mRNA CTD PMID:24136188 NCBI chr11:83,482,958...83,486,136
Ensembl chr11:83,483,037...83,486,436 		JBrowse link
G Thrsp thyroid hormone responsive decreases expression EXP Sulindac results in decreased expression of THRSP mRNA CTD PMID:24136188 NCBI chr 1:151,723,415...151,727,740
Ensembl chr 1:151,723,086...151,728,075 		JBrowse link
G Timm10 translocase of inner mitochondrial membrane 10 increases expression EXP Sulindac results in increased expression of TIMM10 mRNA CTD PMID:24136188 NCBI chr 3:69,908,397...69,911,943
Ensembl chr 3:69,908,456...69,911,940 		JBrowse link
G Timmdc1 translocase of inner mitochondrial membrane domain containing 1 increases expression EXP Sulindac results in increased expression of TIMMDC1 mRNA CTD PMID:24136188 NCBI chr11:62,228,990...62,259,389
Ensembl chr11:62,229,058...62,254,699 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 affects expression ISO Sulindac affects the expression of TIMP1 protein CTD PMID:12388792 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 multiple interactions ISO [Sulindac co-treated with epigallocatechin gallate] results in decreased expression of TIMP3 mRNA CTD PMID:12628509 NCBI chr 7:17,520,827...17,571,850
Ensembl chr 7:17,521,919...17,571,839 		JBrowse link
G Tjp2 tight junction protein 2 increases expression EXP Sulindac results in increased expression of TJP2 mRNA CTD PMID:24136188 NCBI chr 1:221,709,745...221,838,291
Ensembl chr 1:221,709,745...221,838,295 		JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of TLR2 mRNA CTD PMID:20371263 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
G Tm2d1 TM2 domain containing 1 increases expression EXP Sulindac results in increased expression of TM2D1 mRNA CTD PMID:24136188 NCBI chr 5:113,020,793...113,062,134
Ensembl chr 5:113,020,760...113,050,933 		JBrowse link
G Tm7sf3 transmembrane 7 superfamily member 3 decreases expression ISO Sulindac results in decreased expression of TM7SF3 mRNA CTD PMID:11093808 NCBI chr 4:179,518,127...179,550,154
Ensembl chr 4:179,518,130...179,550,154 		JBrowse link
G Tmed9 transmembrane p24 trafficking protein 9 decreases expression ISO Sulindac results in decreased expression of TMED9 mRNA CTD PMID:11906190 NCBI chr17:9,029,646...9,034,160
Ensembl chr17:9,029,646...9,034,176 		JBrowse link
G Tmem127 transmembrane protein 127 increases expression ISO Sulindac results in increased expression of TMEM127 mRNA CTD PMID:11906190 NCBI chr 3:114,466,095...114,478,894
Ensembl chr 3:114,466,171...114,477,519 		JBrowse link
G Tmem141 transmembrane protein 141 increases expression EXP Sulindac results in increased expression of TMEM141 mRNA CTD PMID:24136188 NCBI chr 3:8,439,533...8,441,491
Ensembl chr 3:8,439,533...8,441,491 		JBrowse link
G Tmem209 transmembrane protein 209 decreases expression EXP Sulindac results in decreased expression of TMEM209 mRNA CTD PMID:24136188 NCBI chr 4:59,102,943...59,128,636
Ensembl chr 4:59,101,550...59,128,630 		JBrowse link
G Tmem39a transmembrane protein 39a increases expression ISO Sulindac results in increased expression of TMEM39A mRNA CTD PMID:11906190 NCBI chr11:62,160,631...62,189,964
Ensembl chr11:62,160,631...62,189,964 		JBrowse link
G Tmem60 transmembrane protein 60 increases expression EXP Sulindac results in increased expression of TMEM60 mRNA CTD PMID:24136188 NCBI chr 4:14,210,029...14,214,884
Ensembl chr 4:14,210,029...14,215,063 		JBrowse link
G Tmprss2 transmembrane serine protease 2 increases expression EXP Sulindac results in increased expression of TMPRSS2 mRNA CTD PMID:32808185 NCBI chr11:36,934,306...36,973,779
Ensembl chr11:36,934,306...36,973,715 		JBrowse link
G Tmx1 thioredoxin-related transmembrane protein 1 increases expression EXP Sulindac results in increased expression of TMX1 mRNA CTD PMID:24136188 NCBI chr 6:88,960,691...88,971,744
Ensembl chr 6:88,960,695...88,971,301 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 ISO
EXP		 Sulindac inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Sulindac inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Sulindac inhibits the reaction [TNF protein results in increased activity of CHUK protein]; Sulindac inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Sulindac inhibits the reaction [TNF protein results in increased activity of RELA protein]; Sulindac inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Sulindac inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]; Sulindac inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; Sulindac inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]
Sulindac results in increased expression of TNF
[Sulindac co-treated with Lipopolysaccharides] results in increased secretion of TNF protein; Sulindac inhibits the reaction [Okadaic Acid results in increased expression of TNF protein]		 CTD PMID:10328874 PMID:10757128 PMID:15489888 PMID:16159934 PMID:17328244 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfsf10 TNF superfamily member 10 increases response to substance
multiple interactions		 ISO Sulindac results in increased susceptibility to TNFSF10 protein
[Sulindac co-treated with TNFSF10 protein] results in increased activity of CASP8 protein; TCF4 protein promotes the reaction [Sulindac results in increased susceptibility to TNFSF10 protein]		 CTD PMID:21171083 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135 		JBrowse link
G Tns3 tensin 3 decreases expression ISO Sulindac results in decreased expression of TNS3 mRNA CTD PMID:11906190 NCBI chr14:83,173,649...83,405,671
Ensembl chr14:83,173,649...83,405,998 		JBrowse link
G Tor1a torsin family 1, member A decreases expression EXP Sulindac results in decreased expression of TOR1A mRNA CTD PMID:24136188 NCBI chr 3:14,250,667...14,257,704
Ensembl chr 3:14,250,676...14,257,691 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
decreases expression
increases expression
affects localization		 ISO [Sulindac results in increased abundance of Reactive Oxygen Species] which results in increased activity of TP53 protein; SB 203580 inhibits the reaction [Sulindac affects the localization of TP53 protein]
Sulindac results in decreased expression of TRP53 protein
Sulindac results in increased expression of TP53 protein		 CTD PMID:15020200 PMID:15713900 PMID:17136320 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tpra1 transmembrane protein adipocyte associated 1 increases expression ISO Sulindac results in increased expression of TPRA1 mRNA CTD PMID:11906190 NCBI chr 4:121,364,093...121,375,275
Ensembl chr 4:121,364,091...121,375,269 		JBrowse link
G Trim2 tripartite motif-containing 2 increases expression ISO Sulindac results in increased expression of TRIM2 mRNA CTD PMID:11906190 NCBI chr 2:169,500,628...169,652,855
Ensembl chr 2:169,500,634...169,652,927 		JBrowse link
G Trit1 tRNA isopentenyltransferase 1 decreases expression ISO Sulindac results in decreased expression of TRIT1 mRNA CTD PMID:11906190 NCBI chr 5:135,293,472...135,341,522
Ensembl chr 5:135,295,330...135,338,764 		JBrowse link
G Trub2 TruB pseudouridine synthase family member 2 increases expression EXP Sulindac results in increased expression of TRUB2 mRNA CTD PMID:24136188 NCBI chr 3:13,049,220...13,059,836
Ensembl chr 3:13,033,745...13,059,930 		JBrowse link
G Tsnax translin-associated factor X decreases expression ISO Sulindac results in decreased expression of TSNAX mRNA CTD PMID:11906190 NCBI chr19:52,975,848...52,989,886
Ensembl chr19:52,975,659...52,989,878 		JBrowse link
G Tusc2 tumor suppressor 2, mitochondrial calcium regulator increases expression EXP Sulindac results in increased expression of TUSC2 mRNA CTD PMID:24136188 NCBI chr 8:108,236,838...108,240,056
Ensembl chr 8:108,236,838...108,240,056 		JBrowse link
G Txn1 thioredoxin 1 increases response to substance ISO TXN1 results in increased susceptibility to Sulindac analog CTD PMID:18922898 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629 		JBrowse link
G Txnl1 thioredoxin-like 1 increases expression EXP Sulindac results in increased expression of TXNL1 mRNA CTD PMID:24136188 NCBI chr18:57,125,362...57,155,167
Ensembl chr18:57,125,369...57,165,266 		JBrowse link
G Tyw1 tRNA-yW synthesizing protein 1 homolog increases expression EXP Sulindac results in increased expression of TYW1 mRNA CTD PMID:24136188 NCBI chr12:26,332,020...26,418,286
Ensembl chr12:26,330,351...26,418,208 		JBrowse link
G Ube2e3 ubiquitin-conjugating enzyme E2E 3 decreases expression EXP Sulindac results in decreased expression of UBE2E3 mRNA CTD PMID:24136188 NCBI chr 3:63,786,976...63,851,400
Ensembl chr 3:63,786,650...63,843,237 		JBrowse link
G Ube3a ubiquitin protein ligase E3A increases expression EXP Sulindac results in increased expression of UBE3A mRNA CTD PMID:24136188 NCBI chr 1:110,070,260...110,161,675
Ensembl chr 1:110,070,480...110,157,250 		JBrowse link
G Ubl5 ubiquitin-like 5 decreases expression EXP Sulindac results in decreased expression of UBL5 mRNA CTD PMID:24136188 NCBI chr 8:19,181,504...19,185,224
Ensembl chr 8:19,181,615...19,185,217 		JBrowse link
G Ubqln2 ubiquilin 2 increases expression EXP Sulindac results in increased expression of UBQLN2 mRNA CTD PMID:24136188 NCBI chr  X:17,853,086...17,856,505
Ensembl chr  X:17,853,114...17,856,505 		JBrowse link
G Ufd1 ubiquitin recognition factor in ER associated degradation 1 decreases expression EXP Sulindac results in decreased expression of UFD1 mRNA CTD PMID:24136188 NCBI chr11:82,161,618...82,185,107
Ensembl chr11:82,161,619...82,185,087 		JBrowse link
G Ufl1 Ufm1-specific ligase 1 increases expression EXP Sulindac results in increased expression of UFL1 mRNA CTD PMID:24136188 NCBI chr 5:38,962,721...38,995,134
Ensembl chr 5:38,962,171...38,995,199 		JBrowse link
G Uggt2 UDP-glucose glycoprotein glucosyltransferase 2 increases expression ISO Sulindac results in increased expression of UGGT2 mRNA CTD PMID:11906190 NCBI chr15:96,074,557...96,239,365
Ensembl chr15:96,074,564...96,237,806 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases activity
increases glucuronidation
increases expression		 ISO Sulindac results in increased activity of UGT1A1 protein
UGT1A1 protein results in increased glucuronidation of Sulindac
Sulindac results in increased expression of UGT1A1 mRNA		 CTD PMID:15843492 PMID:17985343 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of Sulindac CTD PMID:15843492 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases glucuronidation ISO UGT1A4 protein results in increased glucuronidation of Sulindac CTD PMID:15843492 NCBI chr 9:88,762,250...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 increases glucuronidation ISO UGT2B7 protein results in increased glucuronidation of Sulindac CTD PMID:15843492 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604 		JBrowse link
G Ung uracil-DNA glycosylase decreases expression ISO Sulindac results in decreased expression of UNG mRNA CTD PMID:11906190 NCBI chr12:42,485,276...42,494,217
Ensembl chr12:42,485,276...42,494,206 		JBrowse link
G Uqcc2 ubiquinol-cytochrome c reductase complex assembly factor 2 decreases expression EXP Sulindac results in decreased expression of UQCC2 mRNA CTD PMID:24136188 NCBI chr20:5,202,837...5,214,541
Ensembl chr20:5,202,837...5,214,164 		JBrowse link
G Uqcc4 ubiquinol-cytochrome c reductase complex assembly factor 4 increases expression EXP Sulindac results in increased expression of UQCC4 mRNA CTD PMID:24136188 NCBI chr10:14,202,217...14,203,519
Ensembl chr10:14,202,243...14,204,029 		JBrowse link
G Vapb VAMP associated protein B and C increases expression EXP Sulindac results in increased expression of VAPB mRNA CTD PMID:24136188 NCBI chr 3:162,535,974...162,578,747
Ensembl chr 3:162,535,905...162,573,763 		JBrowse link
G Vash1 vasohibin 1 decreases expression EXP Sulindac results in decreased expression of VASH1 mRNA CTD PMID:24136188 NCBI chr 6:106,330,374...106,345,740
Ensembl chr 6:106,329,123...106,345,726 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of VCAM1 mRNA CTD PMID:20371263 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Vcp valosin-containing protein decreases expression EXP Sulindac results in decreased expression of VCP mRNA CTD PMID:24136188 NCBI chr 5:57,210,167...57,229,571
Ensembl chr 5:57,210,168...57,229,571 		JBrowse link
G Vps26b VPS26 retromer complex component B decreases expression EXP Sulindac results in decreased expression of VPS26B mRNA CTD PMID:24136188 NCBI chr 8:25,415,877...25,436,985
Ensembl chr 8:25,415,261...25,436,985 		JBrowse link
G Vps26c VPS26 endosomal protein sorting factor C increases expression EXP Sulindac results in increased expression of VPS26C mRNA CTD PMID:24136188 NCBI chr11:33,813,467...33,841,883
Ensembl chr11:33,792,389...33,841,447 		JBrowse link
G Vps29 VPS29 retromer complex component increases expression EXP Sulindac results in increased expression of VPS29 mRNA CTD PMID:24136188 NCBI chr12:34,208,911...34,217,977
Ensembl chr12:34,207,263...34,217,964 		JBrowse link
G Vps35 VPS35 retromer complex component decreases expression EXP Sulindac results in decreased expression of VPS35 mRNA CTD PMID:24136188 NCBI chr19:21,765,771...21,801,620
Ensembl chr19:21,765,749...21,801,618 		JBrowse link
G Vps53 VPS53 subunit of GARP complex increases expression EXP Sulindac results in increased expression of VPS53 mRNA CTD PMID:24136188 NCBI chr10:60,919,820...61,038,674
Ensembl chr10:60,919,820...61,038,676 		JBrowse link
G Wdr3 WD repeat domain 3 increases expression ISO Sulindac results in increased expression of WDR3 mRNA CTD PMID:11906190 NCBI chr 2:187,505,816...187,528,432
Ensembl chr 2:187,505,816...187,528,432 		JBrowse link
G Wdr83os WD repeat domain 83 opposite strand increases expression EXP Sulindac results in increased expression of WDR83OS mRNA CTD PMID:24136188 NCBI chr19:23,075,373...23,076,745
Ensembl chr19:23,075,376...23,076,894 		JBrowse link
G Wwp1 WW domain containing E3 ubiquitin protein ligase 1 decreases expression EXP Sulindac results in decreased expression of WWP1 mRNA CTD PMID:24136188 NCBI chr 5:33,092,379...33,185,887
Ensembl chr 5:33,098,494...33,186,046 		JBrowse link
G Xbp1 X-box binding protein 1 increases expression ISO Sulindac results in increased expression of XBP1 mRNA CTD PMID:11906190 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions ISO [Sulindac results in increased abundance of Reactive Oxygen Species] which results in decreased expression of XIAP protein CTD PMID:17136320 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700 		JBrowse link
G Xpo1 exportin 1 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of XPO1 mRNA CTD PMID:20371263 NCBI chr14:97,233,282...97,275,536
Ensembl chr14:97,233,270...97,275,498 		JBrowse link
G Xpr1 xenotropic and polytropic retrovirus receptor 1 increases expression EXP Sulindac results in increased expression of XPR1 mRNA CTD PMID:24136188 NCBI chr13:67,441,205...67,585,950
Ensembl chr13:67,446,380...67,585,946 		JBrowse link
G Xrcc5 X-ray repair cross complementing 5 decreases expression EXP Sulindac results in decreased expression of XRCC5 mRNA CTD PMID:24136188 NCBI chr 9:73,955,216...74,044,020
Ensembl chr 9:73,955,216...74,044,018 		JBrowse link
G Yme1l1 YME1-like 1 ATPase decreases expression EXP Sulindac results in decreased expression of YME1L1 mRNA CTD PMID:24136188 NCBI chr17:85,287,607...85,326,068
Ensembl chr17:85,287,554...85,326,335 		JBrowse link
G Ythdf3 YTH N6-methyladenosine RNA binding protein F3 increases expression EXP Sulindac results in increased expression of YTHDF3 mRNA CTD PMID:24136188 NCBI chr 2:98,350,304...98,384,608
Ensembl chr 2:98,350,588...98,384,606 		JBrowse link
G Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta increases expression EXP Sulindac results in increased expression of YWHAB mRNA CTD PMID:24136188 NCBI chr 3:152,659,663...152,682,105
Ensembl chr 3:152,659,651...152,682,105 		JBrowse link
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon increases expression EXP Sulindac results in increased expression of YWHAE mRNA CTD PMID:24136188 NCBI chr10:60,584,665...60,622,352
Ensembl chr10:60,584,652...60,671,589 		JBrowse link
G Zc3h13 zinc finger CCCH type containing 13 increases expression EXP Sulindac results in increased expression of ZC3H13 mRNA CTD PMID:24136188 NCBI chr15:50,607,335...50,671,802
Ensembl chr15:50,607,380...50,671,802 		JBrowse link
G Zfp106 zinc finger protein 106 decreases expression EXP Sulindac results in decreased expression of ZFP106 mRNA CTD PMID:24136188 NCBI chr 3:107,459,232...107,510,507
Ensembl chr 3:107,462,096...107,510,481 		JBrowse link
G Zfp148 zinc finger protein 148 decreases expression EXP Sulindac results in decreased expression of ZFP148 mRNA CTD PMID:24136188 NCBI chr11:67,276,455...67,385,803
Ensembl chr11:67,281,707...67,385,772 		JBrowse link
G Zfp281 zinc finger protein 281 increases expression EXP Sulindac results in increased expression of ZFP281 mRNA CTD PMID:24136188 NCBI chr13:48,096,103...48,104,265
Ensembl chr13:48,037,286...48,104,888 		JBrowse link
G Zfp354a zinc finger protein 354A increases expression ISO Sulindac results in increased expression of ZNF354A mRNA CTD PMID:11906190 NCBI chr10:35,396,242...35,408,069
Ensembl chr10:35,396,231...35,408,068 		JBrowse link
G Zfp423 zinc finger protein 423 decreases expression EXP Sulindac results in decreased expression of ZFP423 mRNA CTD PMID:24136188 NCBI chr19:19,111,213...19,407,373
Ensembl chr19:19,110,238...19,407,373 		JBrowse link
G Znhit1 zinc finger, HIT-type containing 1 increases expression EXP Sulindac results in increased expression of ZNHIT1 mRNA CTD PMID:24136188 NCBI chr12:19,686,606...19,692,880
Ensembl chr12:19,686,148...19,692,880 		JBrowse link
G Znhit3 zinc finger, HIT-type containing 3 increases expression EXP Sulindac results in increased expression of ZNHIT3 mRNA CTD PMID:24136188 NCBI chr10:69,775,885...69,790,471
Ensembl chr10:69,748,789...69,790,475
Ensembl chr10:69,748,789...69,790,475 		JBrowse link
sulindac sulfide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 increases expression ISO sulindac sulfide results in increased expression of ABCG2 mRNA CTD PMID:16184548 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Actn1 actinin, alpha 1 decreases expression ISO sulindac sulfide results in decreased expression of ACTN1 mRNA CTD PMID:16184548 NCBI chr 6:98,998,553...99,093,334
Ensembl chr 6:98,998,556...99,093,251 		JBrowse link
G Adam9 ADAM metallopeptidase domain 9 decreases expression ISO sulindac sulfide results in decreased expression of ADAM9 mRNA CTD PMID:16184548 NCBI chr16:67,022,538...67,101,647
Ensembl chr16:67,022,655...67,100,917 		JBrowse link
G Adm adrenomedullin increases expression ISO sulindac sulfide results in increased expression of ADM mRNA CTD PMID:16184548 NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654 		JBrowse link
G Adra2c adrenoceptor alpha 2C decreases expression ISO sulindac sulfide results in decreased expression of ADRA2C mRNA CTD PMID:12734198 NCBI chr14:75,470,884...75,472,846
Ensembl chr14:75,471,143...75,472,846 		JBrowse link
G Ahr aryl hydrocarbon receptor increases localization ISO sulindac sulfide results in increased localization of AHR protein CTD PMID:17985343 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Akap12 A-kinase anchoring protein 12 increases expression ISO sulindac sulfide results in increased expression of AKAP12 mRNA CTD PMID:12734198 NCBI chr 1:40,730,123...40,819,863
Ensembl chr 1:40,730,123...40,819,886 		JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 increases expression ISO sulindac sulfide results in increased expression of AKR1C1 mRNA CTD PMID:16184548 NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326 		JBrowse link
G Aldoc aldolase, fructose-bisphosphate C decreases expression ISO sulindac sulfide results in decreased expression of ALDOC mRNA CTD PMID:16184548 NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066 		JBrowse link
G Alox15 arachidonate 15-lipoxygenase increases expression ISO sulindac sulfide results in increased expression of ALOX15 protein CTD PMID:16166323 NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874 		JBrowse link
G Anxa5 annexin A5 increases expression ISO sulindac sulfide results in increased expression of ANXA5 protein CTD PMID:18678619 NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369 		JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions ISO sulindac sulfide inhibits the reaction [Phosphatidylinositols results in increased expression of APOA1 protein] CTD PMID:19013290 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035 		JBrowse link
G App amyloid beta precursor protein multiple interactions
affects cleavage		 ISO
EXP		 [sulindac sulfide results in decreased activity of PSEN1 protein] which affects the cleavage of APP protein; PSEN1 protein affects the reaction [sulindac sulfide affects the cleavage of APP protein]; PSEN1 protein mutant form promotes the reaction [sulindac sulfide affects the cleavage of APP protein]; sulindac sulfide affects the cleavage of and affects the localization of APP protein; sulindac sulfide affects the reaction [PSEN1 protein affects the cleavage of APP protein]
sulindac sulfide inhibits the reaction [APP protein results in increased uptake of Calcium]		 CTD PMID:11700559 PMID:12637581 PMID:12777371 PMID:12805356 PMID:14690522 More... NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Ar androgen receptor multiple interactions ISO AR protein affects the reaction [sulindac sulfide results in decreased expression of KLK3 protein]; sulindac sulfide results in decreased expression of and results in decreased activity of AR protein CTD PMID:14581372 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Areg amphiregulin increases expression ISO sulindac sulfide results in increased expression of AREG mRNA CTD PMID:16184548 NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535 		JBrowse link
G Arl6ip1 ADP-ribosylation factor like GTPase 6 interacting protein 1 decreases expression ISO sulindac sulfide results in decreased expression of ARL6IP1 mRNA CTD PMID:12734198 NCBI chr 1:172,430,475...172,439,990
Ensembl chr 1:172,430,489...172,439,994 		JBrowse link
G Arpc1b actin related protein 2/3 complex, subunit 1B decreases expression ISO sulindac sulfide results in decreased expression of ARPC1B mRNA CTD PMID:12734198 NCBI chr12:9,482,176...9,495,772
Ensembl chr12:9,480,831...9,495,747 		JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 decreases expression ISO sulindac sulfide results in decreased expression of ASAH1 mRNA CTD PMID:16184548 NCBI chr16:50,966,404...50,997,827
Ensembl chr16:50,966,229...51,008,233 		JBrowse link
G Atf3 activating transcription factor 3 multiple interactions
increases expression		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [sulindac sulfide results in increased expression of ATF3 mRNA]; [sulindac sulfide results in increased phosphorylation of MAPK1 protein] which results in increased expression of ATF3 protein; [sulindac sulfide results in increased phosphorylation of MAPK3 protein] which results in increased expression of ATF3 protein; EGR1 protein promotes the reaction [sulindac sulfide results in increased expression of ATF3 mRNA]; MAP2K1 protein promotes the reaction [sulindac sulfide results in increased expression of ATF3 mRNA]
sulindac sulfide results in increased expression of ATF3 mRNA; sulindac sulfide results in increased expression of ATF3 protein		 CTD PMID:12734198 PMID:15897233 PMID:16079301 PMID:16184548 PMID:21554132 More... NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631 		JBrowse link
G Atp6v0a1 ATPase H+ transporting V0 subunit a1 increases expression ISO sulindac sulfide results in increased expression of ATP6V0A1 mRNA CTD PMID:16184548 NCBI chr10:85,935,802...85,989,901
Ensembl chr10:85,935,854...85,989,895 		JBrowse link
G Aurka aurora kinase A decreases expression ISO sulindac sulfide results in decreased expression of AURKA mRNA CTD PMID:12734198 NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390 		JBrowse link
G Bad BCL2-associated agonist of cell death decreases expression
increases localization
multiple interactions		 ISO sulindac sulfide results in decreased expression of BAD protein
sulindac sulfide results in increased localization of BAD protein
[sulindac sulfide results in decreased expression of YWHAE protein] which results in increased localization of BAD protein; sulindac sulfide promotes the reaction [BAD protein binds to YWHAE protein]		 CTD PMID:17409426 PMID:18678619 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases response to substance EXP BAK1 results in increased susceptibility to sulindac sulfide CTD PMID:18349538 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
decreases expression
affects response to substance		 ISO BAX protein affects the reaction [TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP3 protein]]; BAX protein affects the reaction [TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP8 protein]]; BAX protein affects the reaction [TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP9 protein]]
sulindac sulfide results in increased expression of BAX mRNA
sulindac sulfide results in decreased expression of BAX protein
BAX protein affects the susceptibility to sulindac sulfide		 CTD PMID:12203115 PMID:16886631 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcam basal cell adhesion molecule (Lutheran blood group) decreases expression ISO sulindac sulfide results in decreased expression of BCAM mRNA CTD PMID:12734198 NCBI chr 1:79,415,016...79,429,403
Ensembl chr 1:79,415,017...79,429,403 		JBrowse link
G Bcar1 BCAR1 scaffold protein, Cas family member decreases phosphorylation ISO sulindac sulfide results in decreased phosphorylation of BCAR1 protein CTD PMID:10741720 NCBI chr19:39,679,215...39,713,907
Ensembl chr19:39,679,204...39,713,907 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO sulindac sulfide results in decreased expression of BCL2 protein CTD PMID:18678619 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO sulindac sulfide results in decreased expression of BCL2L1 protein CTD PMID:11912124 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bid BH3 interacting domain death agonist decreases expression
increases cleavage		 ISO sulindac sulfide results in decreased expression of BID protein
sulindac sulfide results in increased cleavage of BID protein		 CTD PMID:12203115 PMID:16886631 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 increases expression ISO sulindac sulfide results in increased expression of BIRC3 mRNA CTD PMID:16184548 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802 		JBrowse link
G Bub1b BUB1 mitotic checkpoint serine/threonine kinase B decreases expression ISO sulindac sulfide results in decreased expression of BUB1B mRNA CTD PMID:16184548 NCBI chr 3:105,563,089...105,615,547
Ensembl chr 3:105,563,138...105,615,547 		JBrowse link
G Cacng3 calcium voltage-gated channel auxiliary subunit gamma 3 increases expression ISO sulindac sulfide results in increased expression of CACNG3 mRNA CTD PMID:16184548 NCBI chr 1:177,201,361...177,297,019
Ensembl chr 1:177,201,288...177,297,024 		JBrowse link
G Casp3 caspase 3 increases activity
increases expression
multiple interactions		 ISO sulindac sulfide results in increased activity of CASP3 protein
sulindac sulfide results in increased expression of CASP3 mRNA
[sulindac sulfide co-treated with TNF protein] results in increased activity of CASP3 protein; BAX protein affects the reaction [TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP3 protein]]; MAP2K1 protein inhibits the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP3 protein]; PTGS2 protein inhibits the reaction [sulindac sulfide results in increased activity of CASP3 protein]; sulindac sulfide results in increased cleavage of and results in increased activity of CASP3 protein; tempol inhibits the reaction [[sulindac sulfide co-treated with TNF protein] results in increased activity of CASP3 protein]; TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP3 protein]		 CTD PMID:11051267 PMID:12203115 PMID:12414664 PMID:14555707 PMID:15548677 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 multiple interactions ISO [sulindac sulfide co-treated with TNF protein] results in increased activity of CASP7 protein; tempol inhibits the reaction [[sulindac sulfide co-treated with TNF protein] results in increased activity of CASP7 protein] CTD PMID:20371263 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity		 ISO BAX protein affects the reaction [TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP8 protein]]; PTGS2 protein inhibits the reaction [sulindac sulfide results in increased activity of CASP8 protein]; sulindac sulfide results in increased cleavage of and results in increased activity of CASP8 protein; TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP8 protein] CTD PMID:11559570 PMID:12203115 PMID:12414664 PMID:16886631 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity		 ISO BAX protein affects the reaction [TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP9 protein]]; PTGS2 protein inhibits the reaction [sulindac sulfide results in increased activity of CASP9 protein]; sulindac sulfide results in increased cleavage of and results in increased activity of CASP9 protein; TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP9 protein] CTD PMID:12203115 PMID:12414664 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccar1 cell division cycle and apoptosis regulator 1 increases expression ISO sulindac sulfide results in increased expression of CCAR1 mRNA CTD PMID:12734198 NCBI chr20:30,685,916...30,728,531
Ensembl chr20:30,685,916...30,728,526 		JBrowse link
G Ccn2 cellular communication network factor 2 decreases expression
increases expression		 ISO sulindac sulfide results in decreased expression of CCN2 mRNA
sulindac sulfide results in increased expression of CCN2 mRNA		 CTD PMID:12734198 PMID:16184548 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression		 ISO sulindac sulfide inhibits the reaction [CTNNB1 protein results in increased expression of CCND1 protein]
sulindac sulfide results in decreased expression of CCND1 mRNA; sulindac sulfide results in decreased expression of CCND1 protein		 CTD PMID:14710233 PMID:15188006 PMID:15767558 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cd4 Cd4 molecule increases expression ISO sulindac sulfide results in increased expression of CD4 mRNA CTD PMID:12734198 NCBI chr 4:157,668,878...157,695,366 JBrowse link
G Cd46 CD46 molecule decreases expression ISO sulindac sulfide results in decreased expression of CD46 mRNA CTD PMID:16184548 NCBI chr13:106,575,586...106,606,325
Ensembl chr13:106,574,858...106,660,445 		JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO sulindac sulfide results in increased expression of and results in increased activity of CDH1 protein CTD PMID:12391285 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdh17 cadherin 17 decreases expression ISO sulindac sulfide results in decreased expression of CDH17 mRNA CTD PMID:16184548 NCBI chr 5:25,262,820...25,314,884
Ensembl chr 5:25,262,758...25,314,884 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
affects activity
increases expression		 ISO PPARD protein inhibits the reaction [sulindac sulfide results in increased expression of CDKN1A mRNA]; PPARG protein promotes the reaction [sulindac sulfide results in increased expression of CDKN1A mRNA]
sulindac sulfide affects the activity of CDKN1A protein
sulindac sulfide results in increased expression of CDKN1A mRNA; sulindac sulfide results in increased expression of CDKN1A protein		 CTD PMID:15694660 PMID:15767558 PMID:16091736 PMID:16184548 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression ISO sulindac sulfide results in increased expression of CEBPB mRNA; sulindac sulfide results in increased expression of CEBPB protein CTD PMID:12734198 PMID:16184548 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator decreases expression ISO sulindac sulfide results in decreased expression of CFLAR protein CTD PMID:11912124 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034 		JBrowse link
G Clp1 cleavage factor polyribonucleotide kinase subunit 1 decreases expression ISO sulindac sulfide results in decreased expression of CLP1 mRNA CTD PMID:12734198 NCBI chr 3:69,806,774...69,818,633
Ensembl chr 3:69,806,778...69,810,421 		JBrowse link
G Cryab crystallin, alpha B increases expression ISO sulindac sulfide results in increased expression of CRYAB mRNA CTD PMID:16184548 NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
decreases expression		 ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sulindac sulfide results in decreased expression of CTNNB1 protein]; sulindac sulfide affects the localization of and results in decreased expression of CTNNB1 protein; sulindac sulfide inhibits the reaction [CTNNB1 protein results in increased expression of CCND1 protein]; sulindac sulfide inhibits the reaction [CTNNB1 protein results in increased expression of MET protein]; sulindac sulfide results in decreased expression of and results in decreased localization of CTNNB1 protein CTD PMID:14555707 PMID:14710233 PMID:15188006 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Ctsc cathepsin C decreases expression ISO sulindac sulfide results in decreased expression of CTSC mRNA CTD PMID:16184548 NCBI chr 1:142,028,386...142,059,841
Ensembl chr 1:142,028,392...142,060,387 		JBrowse link
G Cyb5b cytochrome b5 type B decreases expression ISO sulindac sulfide results in decreased expression of CYB5B mRNA CTD PMID:12734198 NCBI chr19:35,062,871...35,096,741
Ensembl chr19:35,062,813...35,098,249 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO sulindac sulfide results in increased expression of CYP1A1 mRNA CTD PMID:12734198 PMID:16184548 PMID:17985343 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO sulindac sulfide results in increased expression of CYP1A2 mRNA CTD PMID:17985343 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression ISO sulindac sulfide results in increased expression of CYP1B1 mRNA CTD PMID:12734198 PMID:17985343 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Dcbld2 discoidin, CUB and LCCL domain containing 2 increases expression ISO sulindac sulfide results in increased expression of DCBLD2 mRNA CTD PMID:12734198 NCBI chr11:42,125,525...42,179,927
Ensembl chr11:42,125,787...42,179,697 		JBrowse link
G Ddx11 DEAD/H-box helicase 11 decreases expression ISO sulindac sulfide results in decreased expression of DDX11 mRNA CTD PMID:16184548 NCBI chr 9:105,833,234...105,862,844
Ensembl chr 9:105,833,504...105,862,550 		JBrowse link
G Dhcr24 24-dehydrocholesterol reductase decreases expression ISO sulindac sulfide results in decreased expression of DHCR24 mRNA CTD PMID:16184548 NCBI chr 5:121,344,552...121,371,124
Ensembl chr 5:121,344,575...121,371,137 		JBrowse link
G Dhcr7 7-dehydrocholesterol reductase decreases expression ISO sulindac sulfide results in decreased expression of DHCR7 mRNA CTD PMID:16184548 NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055 		JBrowse link
G Dynll1 dynein light chain LC8-type 1 decreases expression ISO sulindac sulfide results in decreased expression of DYNLL1 mRNA CTD PMID:12734198 NCBI chr12:41,312,365...41,316,157
Ensembl chr12:41,312,367...41,314,741 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
decreases expression
increases ubiquitination
increases phosphorylation
decreases phosphorylation		 ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sulindac sulfide results in decreased expression of EGFR protein]; Chloroquine inhibits the reaction [sulindac sulfide results in decreased expression of EGFR protein]
sulindac sulfide results in increased ubiquitination of EGFR protein
sulindac sulfide results in increased phosphorylation of EGFR protein
sulindac sulfide results in decreased phosphorylation of EGFR protein		 CTD PMID:20332299 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Egr1 early growth response 1 multiple interactions
increases expression		 ISO EGR1 protein affects the reaction [sulindac sulfide results in increased expression of THBS1 mRNA]; EGR1 protein promotes the reaction [sulindac sulfide results in increased expression of ATF3 mRNA]; EGR1 protein promotes the reaction [sulindac sulfide results in increased expression of GDF15 mRNA]; ELK1 protein promotes the reaction [sulindac sulfide results in increased expression of EGR1 mRNA]; MAPK1 protein promotes the reaction [sulindac sulfide results in increased expression of EGR1 mRNA]; MAPK3 protein promotes the reaction [sulindac sulfide results in increased expression of EGR1 mRNA]; U 0126 inhibits the reaction [sulindac sulfide results in increased expression of EGR1 mRNA]
sulindac sulfide results in increased expression of EGR1 mRNA; sulindac sulfide results in increased expression of EGR1 protein		 CTD PMID:15509713 PMID:16079301 PMID:16227405 PMID:17599376 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Elk1 ETS transcription factor ELK1 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [sulindac sulfide results in increased phosphorylation of and results in increased activity of ELK1 protein]; ELK1 protein promotes the reaction [sulindac sulfide results in increased expression of EGR1 mRNA]; MAPK1 protein promotes the reaction [sulindac sulfide results in increased phosphorylation of and results in increased activity of ELK1 protein]; MAPK3 protein promotes the reaction [sulindac sulfide results in increased phosphorylation of and results in increased activity of ELK1 protein]; sulindac sulfide results in increased phosphorylation of and affects the activity of ELK1 protein; U 0126 inhibits the reaction [sulindac sulfide results in increased phosphorylation of and results in increased activity of ELK1 protein] CTD PMID:17599376 NCBI chr  X:1,138,826...1,155,713
Ensembl chr  X:1,139,756...1,155,713 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 multiple interactions
decreases expression		 ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sulindac sulfide results in decreased expression of ERBB2 protein] CTD PMID:20332299 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078 		JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 multiple interactions
decreases expression		 ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sulindac sulfide results in decreased expression of ERBB3 protein] CTD PMID:20332299 NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 affects cleavage ISO sulindac sulfide affects the cleavage of ERBB4 protein CTD PMID:12777371 NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595 		JBrowse link
G Esd esterase D increases expression ISO sulindac sulfide results in increased expression of ESD mRNA CTD PMID:12734198 NCBI chr15:50,043,634...50,063,134
Ensembl chr15:50,043,632...50,063,144 		JBrowse link
G Esr1 estrogen receptor 1 decreases expression ISO sulindac sulfide results in decreased expression of ESR1 mRNA; sulindac sulfide results in decreased expression of ESR1 protein CTD PMID:16740773 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Etfb electron transfer flavoprotein subunit beta decreases expression ISO sulindac sulfide results in decreased expression of ETFB mRNA CTD PMID:16184548 NCBI chr 1:93,851,908...93,866,072
Ensembl chr 1:93,851,858...93,866,068 		JBrowse link
G Etnppl ethanolamine-phosphate phospho-lyase increases expression ISO sulindac sulfide results in increased expression of ETNPPL mRNA CTD PMID:12734198 NCBI chr 2:219,173,048...219,194,646
Ensembl chr 2:219,172,978...219,192,212 		JBrowse link
G Fabp1 fatty acid binding protein 1 multiple interactions
increases expression		 ISO 2-chloro-5-nitrobenzanilide inhibits the reaction [sulindac sulfide analog results in increased expression of FABP1 protein]; PPARG protein affects the reaction [sulindac sulfide analog results in increased expression of FABP1 protein] CTD PMID:17602619 PMID:18665581 NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788 		JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions
increases expression		 ISO 2-chloro-5-nitrobenzanilide inhibits the reaction [sulindac sulfide analog results in increased expression of FABP4 protein]; PPARG protein affects the reaction [sulindac sulfide analog results in increased expression of FABP4 protein] CTD PMID:17602619 PMID:18665581 NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578 		JBrowse link
G Fcgrt Fc gamma receptor and transporter decreases expression ISO sulindac sulfide results in decreased expression of FCGRT mRNA CTD PMID:16184548 NCBI chr 1:95,574,436...95,584,171
Ensembl chr 1:95,567,175...95,584,084 		JBrowse link
G Fdps farnesyl diphosphate synthase decreases expression ISO sulindac sulfide results in decreased expression of FDPS mRNA CTD PMID:16184548 NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776 		JBrowse link
G Fgfr4 fibroblast growth factor receptor 4 decreases expression ISO sulindac sulfide results in decreased expression of FGFR4 mRNA CTD PMID:16184548 NCBI chr17:9,461,541...9,476,268
Ensembl chr17:9,461,547...9,476,242 		JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 affects metabolic processing
increases metabolic processing		 ISO FMO3 gene polymorphism affects the metabolism of sulindac sulfide
FMO3 protein results in increased metabolism of sulindac sulfide		 CTD PMID:17142560 PMID:17559352 NCBI chr13:75,309,367...75,334,915
Ensembl chr13:75,309,374...75,328,028 		JBrowse link
G Foxm1 forkhead box M1 decreases expression ISO sulindac sulfide results in decreased expression of FOXM1 mRNA CTD PMID:16184548 NCBI chr 4:161,639,538...161,652,012
Ensembl chr 4:161,638,816...161,650,684 		JBrowse link
G Gal3st4 galactose-3-O-sulfotransferase 4 decreases expression ISO sulindac sulfide results in decreased expression of GAL3ST4 mRNA CTD PMID:16184548 NCBI chr12:17,267,963...17,276,951
Ensembl chr12:17,267,963...17,276,833 		JBrowse link
G Gars1 glycyl-tRNA synthetase 1 increases expression ISO sulindac sulfide results in increased expression of GARS1 mRNA CTD PMID:12734198 NCBI chr 4:84,171,596...84,212,609
Ensembl chr 4:84,171,596...84,212,609 		JBrowse link
G Gdf15 growth differentiation factor 15 multiple interactions
increases expression		 ISO EGR1 protein promotes the reaction [sulindac sulfide results in increased expression of GDF15 mRNA]
sulindac sulfide results in increased expression of GDF15 mRNA; sulindac sulfide results in increased expression of GDF15 protein		 CTD PMID:11895857 PMID:11925476 PMID:12734198 PMID:15180942 PMID:15509713 More... NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055 		JBrowse link
G Gk glycerol kinase increases expression ISO sulindac sulfide results in increased expression of GK mRNA CTD PMID:16184548 NCBI chr  X:50,162,089...50,238,707
Ensembl chr  X:50,163,123...50,238,631 		JBrowse link
G Glcci1 glucocorticoid induced 1 increases expression ISO sulindac sulfide results in increased expression of GLCCI1 mRNA CTD PMID:16184548 NCBI chr 4:36,307,956...36,635,614
Ensembl chr 4:36,307,903...36,635,612 		JBrowse link
G Grn granulin precursor decreases expression ISO sulindac sulfide results in decreased expression of GRN mRNA CTD PMID:16184548 NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO sulindac sulfide binds to and results in decreased activity of GSTP1 protein CTD PMID:15300575 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Hdac1 histone deacetylase 1 decreases expression ISO sulindac sulfide results in decreased expression of HDAC1 mRNA CTD PMID:16184548 NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111 		JBrowse link
G Hgf hepatocyte growth factor decreases expression ISO sulindac sulfide results in decreased expression of HGF mRNA CTD PMID:10807402 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409 		JBrowse link
G Hm13 histocompatibility minor 13 affects binding
multiple interactions		 ISO sulindac sulfide binds to HM13 protein
sulindac sulfide inhibits the reaction [L 685458 binds to HM13 protein]		 CTD PMID:17932033 NCBI chr 3:141,145,792...141,183,557
Ensembl chr 3:141,145,782...141,184,703 		JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases expression ISO sulindac sulfide results in decreased expression of HSD3B1 mRNA CTD PMID:16184548 NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B increases expression ISO sulindac sulfide results in increased expression of HSPA1B mRNA CTD PMID:16184548 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240 		JBrowse link
G Hspa6l-ps1 heat shock protein family A (Hsp70) member 6 like, pseudogene 1 increases expression ISO sulindac sulfide results in increased expression of HSPA6 mRNA CTD PMID:16184548 NCBI chr13:83,273,176...83,274,317 JBrowse link
G Icam2 intercellular adhesion molecule 2 increases expression ISO sulindac sulfide results in increased expression of ICAM2 mRNA CTD PMID:16184548 NCBI chr10:91,308,608...91,319,536
Ensembl chr10:91,308,538...91,315,293 		JBrowse link
G Id1 inhibitor of DNA binding 1 decreases expression ISO sulindac sulfide results in decreased expression of ID1 mRNA; sulindac sulfide results in decreased expression of ID1 protein CTD PMID:16184548 PMID:21554132 NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419 		JBrowse link
G Ifitm1 interferon induced transmembrane protein 1 decreases expression ISO sulindac sulfide results in decreased expression of IFITM1 mRNA CTD PMID:16184548 NCBI chr 1:196,067,163...196,069,169
Ensembl chr 1:196,067,963...196,069,169 		JBrowse link
G Ifitm3 interferon induced transmembrane protein 3 decreases expression ISO sulindac sulfide results in decreased expression of IFITM3 mRNA CTD PMID:16184548 NCBI chr 1:196,111,026...196,112,135
Ensembl chr 1:196,111,043...196,112,203 		JBrowse link
G Ifrd1 interferon-related developmental regulator 1 increases expression ISO sulindac sulfide results in increased expression of IFRD1 mRNA CTD PMID:12734198 NCBI chr 6:57,269,395...57,317,833
Ensembl chr 6:57,269,384...57,288,990 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta decreases activity ISO sulindac sulfide results in decreased activity of IKBKB protein CTD PMID:11912124 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Il13ra1 interleukin 13 receptor subunit alpha 1 decreases expression ISO sulindac sulfide results in decreased expression of IL13RA1 mRNA CTD PMID:16184548 NCBI chr  X:115,348,822...115,408,682
Ensembl chr  X:115,348,860...115,408,681
Ensembl chr11:115,348,860...115,408,681 		JBrowse link
G Il1r1 interleukin 1 receptor type 1 increases expression ISO sulindac sulfide results in increased expression of IL1R1 mRNA CTD PMID:16184548 NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937 		JBrowse link
G Ilf3 interleukin enhancer binding factor 3 decreases expression ISO sulindac sulfide results in decreased expression of ILF3 mRNA CTD PMID:16184548 NCBI chr 8:19,922,409...19,960,495
Ensembl chr 8:19,922,460...19,960,350 		JBrowse link
G Insig1 insulin induced gene 1 decreases expression ISO sulindac sulfide results in decreased expression of INSIG1 mRNA CTD PMID:12734198 NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952 		JBrowse link
G Isg20 interferon stimulated exonuclease gene 20 increases expression ISO sulindac sulfide results in increased expression of ISG20 mRNA CTD PMID:16184548 NCBI chr 1:132,829,303...132,837,027
Ensembl chr 1:132,815,123...132,837,027 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 decreases expression ISO sulindac sulfide results in decreased expression of ITPR1 mRNA CTD PMID:15767558 NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491 		JBrowse link
G Jag2 jagged canonical Notch ligand 2 increases expression ISO sulindac sulfide results in increased expression of JAG2 mRNA CTD PMID:16184548 NCBI chr 6:131,983,059...132,005,665
Ensembl chr 6:131,983,056...132,005,818 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO sulindac sulfide results in increased expression of JUN mRNA CTD PMID:16704987 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Kalrn kalirin, RhoGEF kinase decreases expression ISO sulindac sulfide results in decreased expression of KALRN mRNA CTD PMID:16184548 NCBI chr11:66,198,155...66,803,166
Ensembl chr11:66,198,173...66,797,610 		JBrowse link
G Klhl21 kelch-like family member 21 increases expression ISO sulindac sulfide results in increased expression of KLHL21 mRNA CTD PMID:16184548 NCBI chr 5:162,514,888...162,523,545
Ensembl chr 5:162,514,765...162,523,545 		JBrowse link
G Klk1c10 kallikrein 1-related peptidase C10 decreases expression
multiple interactions		 ISO sulindac sulfide results in decreased expression of KLK3 protein
AR protein affects the reaction [sulindac sulfide results in decreased expression of KLK3 protein]		 CTD PMID:14581372 NCBI chr 1:94,402,993...94,407,052
Ensembl chr 1:94,402,993...94,407,052 		JBrowse link
G Krt14 keratin 14 increases expression ISO sulindac sulfide results in increased expression of KRT14 mRNA CTD PMID:16184548 NCBI chr10:85,137,786...85,142,054
Ensembl chr10:85,066,802...85,171,799 		JBrowse link
G Krt16 keratin 16 increases expression ISO sulindac sulfide results in increased expression of KRT16 mRNA CTD PMID:16184548 NCBI chr10:85,168,357...85,171,816
Ensembl chr10:85,066,802...85,171,799 		JBrowse link
G Krt17 keratin 17 increases expression ISO sulindac sulfide results in increased expression of KRT17 mRNA CTD PMID:16184548 NCBI chr10:85,178,673...85,183,392
Ensembl chr10:85,178,675...85,183,392 		JBrowse link
G Krt19 keratin 19 decreases expression ISO sulindac sulfide results in decreased expression of KRT19 mRNA CTD PMID:12734198 NCBI chr10:85,075,835...85,080,552
Ensembl chr10:85,066,802...85,171,799 		JBrowse link
G Krt5 keratin 5 decreases expression ISO sulindac sulfide results in decreased expression of KRT5 mRNA CTD PMID:12734198 NCBI chr 7:132,846,132...132,851,861
Ensembl chr 7:132,846,136...132,851,850 		JBrowse link
G Lamc1 laminin subunit gamma 1 increases expression
decreases expression		 ISO sulindac sulfide results in increased expression of LAMC1 mRNA
sulindac sulfide results in decreased expression of LAMC1 protein		 CTD PMID:15561105 PMID:16184548 NCBI chr13:65,374,372...65,501,492
Ensembl chr13:65,374,372...65,501,492 		JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 decreases expression ISO sulindac sulfide results in decreased expression of LAMP1 mRNA CTD PMID:16184548 NCBI chr16:76,355,982...76,380,700
Ensembl chr16:76,355,984...76,381,883 		JBrowse link
G Ldha lactate dehydrogenase A decreases expression ISO sulindac sulfide results in decreased expression of LDHA mRNA CTD PMID:12734198 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472 		JBrowse link
G Ldlr low density lipoprotein receptor decreases expression ISO sulindac sulfide results in decreased expression of LDLR mRNA CTD PMID:16184548 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580 		JBrowse link
G Mad2l1 mitotic arrest deficient 2 like 1 decreases expression ISO sulindac sulfide results in decreased expression of MAD2L1 mRNA; sulindac sulfide results in decreased expression of MAD2L1 protein CTD PMID:12734198 NCBI chr 4:95,906,692...95,918,885
Ensembl chr 4:95,906,817...95,913,470 		JBrowse link
G Magi1 membrane associated guanylate kinase, WW and PDZ domain containing 1 increases expression ISO sulindac sulfide results in increased expression of MAGI1 mRNA CTD PMID:12734198 NCBI chr 4:126,205,663...126,811,354
Ensembl chr 4:126,206,816...126,811,691 		JBrowse link
G Mal mal, T-cell differentiation protein decreases expression ISO sulindac sulfide results in decreased expression of MAL mRNA CTD PMID:16184548 NCBI chr 3:114,864,378...114,888,136
Ensembl chr 3:114,864,378...114,888,136 		JBrowse link
G Man2b2 mannosidase, alpha, class 2B, member 2 increases expression ISO sulindac sulfide results in increased expression of MAN2B2 mRNA CTD PMID:12734198 NCBI chr14:73,969,079...73,994,089
Ensembl chr14:73,969,003...74,004,281 		JBrowse link
G Manf mesencephalic astrocyte-derived neurotrophic factor increases expression ISO sulindac sulfide results in increased expression of MANF mRNA CTD PMID:16184548 NCBI chr 8:107,500,856...107,551,595
Ensembl chr 8:107,548,352...107,551,438 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 multiple interactions ISO MAP2K1 protein inhibits the reaction [sulindac sulfide results in decreased phosphorylation of MAPK1 protein]; MAP2K1 protein inhibits the reaction [sulindac sulfide results in decreased phosphorylation of MAPK3 protein]; MAP2K1 protein inhibits the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP3 protein]; MAP2K1 protein promotes the reaction [sulindac sulfide results in increased expression of ATF3 mRNA] CTD PMID:15548677 PMID:16079301 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147 		JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 decreases expression ISO sulindac sulfide results in decreased expression of MAP3K1 mRNA CTD PMID:12734198 NCBI chr 2:43,348,572...43,414,706
Ensembl chr 2:43,350,098...43,414,463 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
decreases phosphorylation		 ISO [sulindac sulfide results in increased phosphorylation of MAPK1 protein] which results in increased expression of ATF3 protein; [sulindac sulfide results in increased phosphorylation of MAPK1 protein] which results in increased expression of THBS1 protein; MAP2K1 protein inhibits the reaction [sulindac sulfide results in decreased phosphorylation of MAPK1 protein]; MAPK1 protein promotes the reaction [sulindac sulfide results in increased expression of EGR1 mRNA]; MAPK1 protein promotes the reaction [sulindac sulfide results in increased phosphorylation of and results in increased activity of ELK1 protein]; sulindac sulfide results in increased phosphorylation of and affects the activity of MAPK1 protein CTD PMID:15548677 PMID:16079301 PMID:17599376 PMID:18261746 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk10 mitogen activated protein kinase 10 increases expression ISO sulindac sulfide results in increased expression of MAPK10 mRNA CTD PMID:12734198 NCBI chr14:6,497,662...6,790,109
Ensembl chr14:6,497,707...6,786,201 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
decreases phosphorylation		 ISO [sulindac sulfide results in increased phosphorylation of MAPK3 protein] which results in increased expression of ATF3 protein; [sulindac sulfide results in increased phosphorylation of MAPK3 protein] which results in increased expression of THBS1 protein; MAP2K1 protein inhibits the reaction [sulindac sulfide results in decreased phosphorylation of MAPK3 protein]; MAPK3 protein promotes the reaction [sulindac sulfide results in increased expression of EGR1 mRNA]; MAPK3 protein promotes the reaction [sulindac sulfide results in increased phosphorylation of and results in increased activity of ELK1 protein]; sulindac sulfide results in increased phosphorylation of and affects the activity of MAPK3 protein CTD PMID:15548677 PMID:16079301 PMID:17599376 PMID:18261746 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases activity ISO sulindac sulfide results in increased activity of MAPK8 protein CTD PMID:11051267 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mars2 methionyl-tRNA synthetase 2, mitochondrial increases expression ISO sulindac sulfide results in increased expression of MARS2 mRNA CTD PMID:16184548 NCBI chr 9:56,720,408...56,729,991
Ensembl chr 9:56,720,983...56,723,820 		JBrowse link
G Mcm2 minichromosome maintenance complex component 2 decreases expression ISO sulindac sulfide results in decreased expression of MCM2 mRNA CTD PMID:16184548 NCBI chr 4:121,346,434...121,360,962
Ensembl chr 4:121,346,434...121,360,847 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase multiple interactions ISO sulindac sulfide inhibits the reaction [CTNNB1 protein results in increased expression of MET protein] CTD PMID:14710233 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876 		JBrowse link
G Mmp1 matrix metallopeptidase 1 decreases expression
increases expression		 ISO sulindac sulfide results in decreased expression of MMP1 mRNA
sulindac sulfide results in increased expression of MMP1 mRNA		 CTD PMID:15767558 PMID:16184548 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097 		JBrowse link
G Mmp10 matrix metallopeptidase 10 increases expression ISO sulindac sulfide results in increased expression of MMP10 mRNA CTD PMID:16184548 NCBI chr 8:4,689,840...4,697,748
Ensembl chr 8:4,689,840...4,697,748 		JBrowse link
G Mras muscle RAS oncogene homolog increases expression ISO sulindac sulfide results in increased expression of MRAS mRNA CTD PMID:16184548 NCBI chr 8:99,944,036...100,006,771
Ensembl chr 8:99,944,036...99,996,408 		JBrowse link
G Msmo1 methylsterol monooxygenase 1 decreases expression ISO sulindac sulfide results in decreased expression of MSMO1 mRNA CTD PMID:12734198 NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016 		JBrowse link
G Msx1 msh homeobox 1 decreases expression ISO sulindac sulfide results in decreased expression of MSX1 mRNA; sulindac sulfide results in decreased expression of MSX1 protein CTD PMID:12734198 NCBI chr14:72,961,036...72,964,970
Ensembl chr14:72,961,148...72,964,966 		JBrowse link
G Mtfr1 mitochondrial fission regulator 1 increases expression ISO sulindac sulfide results in increased expression of MTFR1 mRNA CTD PMID:16184548 NCBI chr 2:101,678,331...101,713,547
Ensembl chr 2:101,679,265...101,713,544 		JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase increases expression ISO sulindac sulfide results in increased expression of MTHFD2 mRNA CTD PMID:12734198 NCBI chr 4:115,811,135...115,822,663
Ensembl chr 4:115,811,139...115,822,608 		JBrowse link
G Muc1 mucin 1, cell surface associated decreases expression ISO sulindac sulfide results in decreased expression of MUC1 mRNA CTD PMID:16184548 NCBI chr 2:174,635,989...174,640,738
Ensembl chr 2:174,635,995...174,640,733 		JBrowse link
G Mx1 MX dynamin like GTPase 1 decreases expression ISO sulindac sulfide results in decreased expression of MX1 mRNA CTD PMID:16184548 NCBI chr11:36,799,659...36,825,209
Ensembl chr11:36,799,660...36,823,507 		JBrowse link
G Myh10 myosin heavy chain 10 increases expression ISO sulindac sulfide results in increased expression of MYH10 mRNA CTD PMID:12734198 NCBI chr10:53,393,901...53,525,174
Ensembl chr10:53,394,389...53,525,165 		JBrowse link
G Ncapd3 non-SMC condensin II complex, subunit D3 decreases expression ISO sulindac sulfide results in decreased expression of NCAPD3 mRNA CTD PMID:16184548 NCBI chr 8:25,437,067...25,506,375
Ensembl chr 8:25,437,123...25,506,373 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 decreases activity ISO sulindac sulfide results in decreased activity of NFKB1 protein CTD PMID:12085227 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha decreases phosphorylation ISO sulindac sulfide results in decreased phosphorylation of NFKBIA protein CTD PMID:12085227 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Niban1 niban apoptosis regulator 1 increases expression ISO sulindac sulfide results in increased expression of NIBAN1 mRNA CTD PMID:12734198 NCBI chr13:63,674,240...63,827,748
Ensembl chr13:63,674,171...63,827,729 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity
increases expression		 ISO sulindac sulfide results in increased activity of NQO1 protein
sulindac sulfide results in increased expression of NQO1 mRNA		 CTD PMID:17985343 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nup133 nucleoporin 133 increases expression ISO sulindac sulfide results in increased expression of NUP133 mRNA CTD PMID:12734198 NCBI chr19:51,891,606...51,941,243
Ensembl chr19:51,891,629...51,941,239 		JBrowse link
G Odc1 ornithine decarboxylase 1 increases expression ISO sulindac sulfide results in increased expression of ODC1 mRNA CTD PMID:16184548 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
decreases expression
increases cleavage		 ISO (4-(((2-(3-fluoro-4-(trifluoromethyl)phenyl)-4-methyl-1,3-thiazol-5-yl)methyl)sulfanyl)-2-methylphenoxy)acetic acid promotes the reaction [sulindac sulfide results in increased cleavage of PARP1 protein]
sulindac sulfide results in decreased expression of PARP1 mRNA		 CTD PMID:12663503 PMID:16184548 PMID:16886631 PMID:18678619 PMID:21400612 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pawr pro-apoptotic WT1 regulator increases expression ISO sulindac sulfide results in increased expression of PAWR mRNA CTD PMID:10833474 NCBI chr 7:43,645,028...43,725,033
Ensembl chr 7:43,645,084...43,725,028 		JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 decreases expression ISO sulindac sulfide results in decreased expression of PCSK9 mRNA CTD PMID:16184548 NCBI chr 5:121,211,278...121,233,688
Ensembl chr 5:121,211,278...121,233,688 		JBrowse link
G Pgam1 phosphoglycerate mutase 1 decreases expression ISO sulindac sulfide results in decreased expression of PGAM1 mRNA CTD PMID:12734198 NCBI chr 1:240,723,832...240,731,443
Ensembl chr 1:240,723,920...240,738,452 		JBrowse link
G Pgr progesterone receptor decreases expression ISO sulindac sulfide results in decreased expression of PGR mRNA; sulindac sulfide results in decreased expression of PGR protein CTD PMID:16740773 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Pkm pyruvate kinase M1/2 decreases expression ISO sulindac sulfide results in decreased expression of PKM mRNA CTD PMID:16184548 NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599 		JBrowse link
G Plau plasminogen activator, urokinase decreases expression ISO sulindac sulfide results in decreased expression of PLAU mRNA CTD PMID:15767558 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO sulindac sulfide results in increased expression of PMAIP1 mRNA CTD PMID:16184548 NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429 		JBrowse link
G Pold3 DNA polymerase delta 3, accessory subunit decreases expression ISO sulindac sulfide results in decreased expression of POLD3 mRNA CTD PMID:16184548 NCBI chr 1:154,417,893...154,456,687
Ensembl chr 1:154,418,084...154,456,665 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression ISO sulindac sulfide results in increased expression of PPARA mRNA CTD PMID:11948457 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Ppard peroxisome proliferator-activated receptor delta multiple interactions
increases expression
decreases activity
decreases expression		 ISO PPARD protein affects the reaction [sulindac sulfide results in decreased expression of YWHAE protein]; PPARD protein inhibits the reaction [sulindac sulfide results in increased expression of CDKN1A mRNA]; sulindac sulfide binds to and results in decreased activity of PPARD protein
sulindac sulfide results in increased expression of PPARD mRNA; sulindac sulfide results in increased expression of PPARD protein
sulindac sulfide results in decreased activity of PPARD protein
sulindac sulfide results in decreased expression of PPARD mRNA; sulindac sulfide results in decreased expression of PPARD protein		 CTD PMID:10555149 PMID:11948457 PMID:16091736 PMID:17409426 PMID:18678619 More... NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases expression
increases activity
affects binding		 ISO [sulindac sulfide results in increased activity of PPARG protein] which results in increased expression of PTGS2 protein; PPARG protein affects the reaction [sulindac sulfide analog results in increased expression of FABP1 protein]; PPARG protein affects the reaction [sulindac sulfide analog results in increased expression of FABP4 protein]; PPARG protein promotes the reaction [sulindac sulfide results in increased expression of CDKN1A mRNA]; sulindac sulfide analog binds to and results in increased activity of PPARG protein; sulindac sulfide analog inhibits the reaction [troglitazone binds to PPARG protein]; sulindac sulfide binds to and results in increased activity of PPARG protein
sulindac sulfide results in increased expression of PPARG mRNA
sulindac sulfide analog binds to PPARG protein		 CTD PMID:10866999 PMID:11948457 PMID:16091736 PMID:17602619 PMID:18665581 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppp2r1a protein phosphatase 2 scaffold subunit A alpha decreases expression ISO sulindac sulfide results in decreased expression of PPP2R1A mRNA CTD PMID:12734198 NCBI chr 1:60,540,223...60,559,467
Ensembl chr 1:60,540,194...60,560,129 		JBrowse link
G Ppt1 palmitoyl-protein thioesterase 1 decreases expression ISO sulindac sulfide results in decreased expression of PPT1 mRNA CTD PMID:16184548 NCBI chr 5:135,121,164...135,142,048
Ensembl chr 5:135,121,163...135,142,048 		JBrowse link
G Prep prolyl endopeptidase increases expression ISO sulindac sulfide results in increased expression of PREP mRNA CTD PMID:12734198 NCBI chr20:48,556,211...48,653,165
Ensembl chr20:48,556,280...48,654,466 		JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha increases expression ISO sulindac sulfide results in increased expression of PRKACA mRNA CTD PMID:16184548 NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430 		JBrowse link
G Prkcsh PRKCSH beta subunit of glucosidase II decreases expression ISO sulindac sulfide results in decreased expression of PRKCSH mRNA CTD PMID:16184548 NCBI chr 8:20,534,787...20,546,493
Ensembl chr 8:20,534,880...20,546,492 		JBrowse link
G Prrx1 paired related homeobox 1 decreases expression ISO sulindac sulfide results in decreased expression of PRRX1 mRNA CTD PMID:16184548 NCBI chr13:75,600,777...75,671,896
Ensembl chr13:75,601,706...75,670,866 		JBrowse link
G Prss23 serine protease 23 decreases expression ISO sulindac sulfide results in decreased expression of PRSS23 mRNA CTD PMID:12734198 NCBI chr 1:143,402,725...143,422,182
Ensembl chr 1:143,401,396...143,422,091 		JBrowse link
G Psen1 presenilin 1 decreases response to substance
decreases activity
multiple interactions		 ISO PSEN1 gene mutant form results in decreased susceptibility to sulindac sulfide
sulindac sulfide results in decreased activity of PSEN1 protein
[sulindac sulfide results in decreased activity of PSEN1 protein] which affects the cleavage of APP protein; PSEN1 protein affects the reaction [sulindac sulfide affects the cleavage of APP protein]; PSEN1 protein mutant form promotes the reaction [sulindac sulfide affects the cleavage of APP protein]; sulindac sulfide affects the reaction [PSEN1 protein affects the cleavage of APP protein]		 CTD PMID:12805356 PMID:17573346 PMID:17962197 NCBI chr 6:103,323,052...103,375,088
Ensembl chr 6:103,323,120...103,371,650 		JBrowse link
G Psmc2 proteasome 26S subunit, ATPase 2 decreases expression ISO sulindac sulfide results in decreased expression of PSMC2 mRNA CTD PMID:16184548 NCBI chr 4:13,255,850...13,270,160
Ensembl chr 4:13,255,856...13,270,185 		JBrowse link
G Ptgdr2 prostaglandin D2 receptor 2 affects binding
multiple interactions		 ISO sulindac sulfide binds to PTGDR2 protein
[sulindac sulfide binds to PTGDR2 protein] which results in decreased abundance of Cyclic AMP; sulindac sulfide inhibits the reaction [Prostaglandin D2 binds to PTGDR2 protein]		 CTD PMID:15563582 NCBI chr 1:207,585,088...207,590,275
Ensembl chr 1:207,587,917...207,589,213 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases activity ISO sulindac sulfide results in decreased activity of PTGS1 protein CTD PMID:11245490 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
decreases activity
increases response to substance		 ISO [sulindac sulfide results in increased activity of PPARG protein] which results in increased expression of PTGS2 protein; PTGS2 protein inhibits the reaction [sulindac sulfide results in increased activity of CASP3 protein]; PTGS2 protein inhibits the reaction [sulindac sulfide results in increased activity of CASP8 protein]; PTGS2 protein inhibits the reaction [sulindac sulfide results in increased activity of CASP9 protein]; sulindac sulfide inhibits the reaction [PTGS2 protein results in decreased expression of TNFRSF10B mRNA]; sulindac sulfide inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]
sulindac sulfide results in increased expression of PTGS2 mRNA; sulindac sulfide results in increased expression of PTGS2 protein
sulindac sulfide results in decreased activity of PTGS2 protein
PTGS2 protein results in increased susceptibility to sulindac sulfide		 CTD PMID:10485483 PMID:10866999 PMID:11245490 PMID:11948457 PMID:12208739 More... NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ptk2 protein tyrosine kinase 2 decreases phosphorylation ISO sulindac sulfide results in decreased phosphorylation of PTK2 protein CTD PMID:10741720 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783 		JBrowse link
G Ptprf protein tyrosine phosphatase, receptor type, F decreases expression ISO sulindac sulfide results in decreased expression of PTPRF mRNA CTD PMID:16184548 NCBI chr 5:131,741,959...131,824,000
Ensembl chr 5:131,742,754...131,810,023 		JBrowse link
G Pvt1 Pvt1 oncogene increases expression ISO sulindac sulfide results in increased expression of PVT1 mRNA CTD PMID:12734198 NCBI chr 7:93,656,528...93,879,938 JBrowse link
G Ranbp1 RAN binding protein 1 increases expression ISO sulindac sulfide results in increased expression of RANBP1 mRNA CTD PMID:12734198 NCBI chr11:82,742,603...82,750,836
Ensembl chr11:82,742,600...82,750,838 		JBrowse link
G Rap1gap Rap1 GTPase-activating protein increases expression ISO sulindac sulfide results in increased expression of RAP1GAP mRNA CTD PMID:12734198 NCBI chr 5:149,873,987...149,939,254
Ensembl chr 5:149,892,019...149,939,253 		JBrowse link
G Rb1 RB transcriptional corepressor 1 affects activity ISO sulindac sulfide affects the activity of RB1 protein CTD PMID:15694660 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Recql4 RecQ like helicase 4 decreases expression ISO sulindac sulfide results in decreased expression of RECQL4 mRNA CTD PMID:16184548 NCBI chr 7:108,423,453...108,430,790
Ensembl chr 7:108,423,455...108,430,619 		JBrowse link
G Reg1a regenerating family member 1 alpha decreases expression ISO sulindac sulfide results in decreased expression of REG1A mRNA CTD PMID:16184548 NCBI chr 4:110,892,451...110,895,115
Ensembl chr 4:110,892,453...110,895,570 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases activity ISO sulindac sulfide results in decreased activity of RELA protein CTD PMID:11912124 PMID:12085227 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rere arginine-glutamic acid dipeptide repeats decreases expression ISO sulindac sulfide results in decreased expression of RERE mRNA CTD PMID:12734198 NCBI chr 5:160,765,855...161,097,678
Ensembl chr 5:160,765,934...161,097,677 		JBrowse link
G Rgs16 regulator of G-protein signaling 16 increases expression ISO sulindac sulfide results in increased expression of RGS16 mRNA CTD PMID:16184548 NCBI chr13:65,887,668...65,892,862
Ensembl chr13:65,887,530...65,892,857 		JBrowse link
G Rhoa ras homolog family member A multiple interactions ISO [sulindac sulfide results in increased activity of RHOA protein] which results in increased expression of THBS1 protein; RHOA protein promotes the reaction [sulindac sulfide results in increased expression of THBS1 protein] CTD PMID:18261746 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746 		JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 decreases expression ISO sulindac sulfide results in decreased expression of RRM2 mRNA CTD PMID:12734198 NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773 		JBrowse link
G Rrs1 ribosome biogenesis regulator 1 homolog increases expression ISO sulindac sulfide results in increased expression of RRS1 mRNA CTD PMID:12734198 NCBI chr 5:9,733,486...9,735,119
Ensembl chr 5:9,733,091...9,735,140 		JBrowse link
G Serpinb5 serpin family B member 5 decreases expression ISO sulindac sulfide results in decreased expression of SERPINB5 mRNA CTD PMID:15897233 NCBI chr13:22,985,557...23,005,756
Ensembl chr13:22,985,557...23,005,756 		JBrowse link
G Serpine1 serpin family E member 1 increases expression ISO sulindac sulfide results in increased expression of SERPINE1 mRNA CTD PMID:15897233 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Skp2 S-phase kinase associated protein 2 decreases expression ISO sulindac sulfide results in decreased expression of SKP2 mRNA CTD PMID:16184548 NCBI chr 2:58,161,226...58,189,293
Ensembl chr 2:58,161,229...58,189,338 		JBrowse link
G Slc25a1 solute carrier family 25 member 1 decreases expression ISO sulindac sulfide results in decreased expression of SLC25A1 mRNA CTD PMID:16184548 NCBI chr11:83,055,764...83,058,781
Ensembl chr11:83,055,748...83,058,781 		JBrowse link
G Slc25a45 solute carrier family 25, member 45 increases expression ISO sulindac sulfide results in increased expression of SLC25A45 mRNA CTD PMID:12734198 NCBI chr 1:203,166,362...203,174,473
Ensembl chr 1:203,166,683...203,174,473 		JBrowse link
G Slc3a2 solute carrier family 3 member 2 increases expression ISO sulindac sulfide results in increased expression of SLC3A2 mRNA CTD PMID:16184548 NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931 		JBrowse link
G Sprr1b small proline-rich protein 1B increases expression ISO sulindac sulfide results in increased expression of SPRR1B mRNA CTD PMID:16184548 NCBI chr 2:178,008,844...178,010,742
Ensembl chr 2:178,009,130...178,009,567 		JBrowse link
G Sptbn1 spectrin, beta, non-erythrocytic 1 decreases expression ISO sulindac sulfide results in decreased expression of SPTBN1 mRNA CTD PMID:12734198 NCBI chr14:103,841,713...104,016,900
Ensembl chr14:103,842,684...104,008,507 		JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO sulindac sulfide results in increased expression of SQSTM1 mRNA CTD PMID:16184548 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 decreases expression ISO sulindac sulfide results in decreased expression of SREBF2 mRNA CTD PMID:16184548 NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
decreases expression		 ISO sulindac sulfide results in decreased expression of and results in decreased phosphorylation of STAT3 protein
sulindac sulfide results in decreased expression of STAT3 mRNA		 CTD PMID:17566705 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Stc2 stanniocalcin 2 increases expression ISO sulindac sulfide results in increased expression of STC2 mRNA CTD PMID:12734198 NCBI chr10:16,251,046...16,260,815
Ensembl chr10:16,250,853...16,262,973 		JBrowse link
G Stk17b serine/threonine kinase 17b increases expression ISO sulindac sulfide results in increased expression of STK17B mRNA CTD PMID:16184548 NCBI chr 9:55,307,485...55,338,085
Ensembl chr 9:55,307,668...55,338,031 		JBrowse link
G Syde1 synapse defective Rho GTPase homolog 1 increases expression ISO sulindac sulfide results in increased expression of SYDE1 mRNA CTD PMID:12734198 NCBI chr 7:11,032,931...11,038,917
Ensembl chr 7:11,032,898...11,039,869 		JBrowse link
G Tfap2b transcription factor AP-2 beta increases expression ISO sulindac sulfide results in increased expression of TFAP2B mRNA CTD PMID:16184548 NCBI chr 9:21,786,251...21,816,054
Ensembl chr 9:21,786,258...21,814,520 		JBrowse link
G Tff3 trefoil factor 3 decreases expression ISO sulindac sulfide results in decreased expression of TFF3 mRNA CTD PMID:16184548 NCBI chr20:9,193,259...9,197,969
Ensembl chr20:9,193,262...9,198,054 		JBrowse link
G Thbs1 thrombospondin 1 multiple interactions
increases expression		 ISO [sulindac sulfide results in increased activity of RHOA protein] which results in increased expression of THBS1 protein; [sulindac sulfide results in increased phosphorylation of MAPK1 protein] which results in increased expression of THBS1 protein; [sulindac sulfide results in increased phosphorylation of MAPK3 protein] which results in increased expression of THBS1 protein; EGR1 protein affects the reaction [sulindac sulfide results in increased expression of THBS1 mRNA]; RHOA protein promotes the reaction [sulindac sulfide results in increased expression of THBS1 protein]; U 0126 inhibits the reaction [sulindac sulfide results in increased expression of THBS1 mRNA]; U 0126 inhibits the reaction [sulindac sulfide results in increased expression of THBS1 protein]
sulindac sulfide results in increased expression of THBS1 mRNA; sulindac sulfide results in increased expression of THBS1 protein		 CTD PMID:16227405 PMID:18261746 NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440 		JBrowse link
G Tk1 thymidine kinase 1 decreases expression ISO sulindac sulfide results in decreased expression of TK1 mRNA CTD PMID:16184548 NCBI chr10:103,034,755...103,046,125
Ensembl chr10:103,031,521...103,046,920 		JBrowse link
G Tmpo thymopoietin decreases expression ISO sulindac sulfide results in decreased expression of TMPO mRNA CTD PMID:16184548 NCBI chr 7:25,642,752...25,667,756
Ensembl chr 7:25,586,725...25,667,727 		JBrowse link
G Tmsb4x thymosin beta 4, X-linked decreases expression ISO sulindac sulfide results in decreased expression of TMSB4X mRNA CTD PMID:15292456 NCBI chr  X:27,144,666...27,146,667
Ensembl chr  X:27,128,610...27,146,667 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [sulindac sulfide co-treated with TNF protein] results in increased activity of CASP3 protein; [sulindac sulfide co-treated with TNF protein] results in increased activity of CASP7 protein; sulindac sulfide inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; tempol inhibits the reaction [[sulindac sulfide co-treated with TNF protein] results in increased activity of CASP3 protein]; tempol inhibits the reaction [[sulindac sulfide co-treated with TNF protein] results in increased activity of CASP7 protein] CTD PMID:10866999 PMID:20371263 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b increases expression ISO sulindac sulfide results in increased expression of TNFRSF10A mRNA; sulindac sulfide results in increased expression of TNFRSF10A protein CTD PMID:15180942 NCBI chr15:44,840,386...44,868,318
Ensembl chr15:44,840,386...44,867,467 		JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO BAX protein affects the reaction [TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP3 protein]]; BAX protein affects the reaction [TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP8 protein]]; BAX protein affects the reaction [TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP9 protein]]; TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP3 protein]; TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP8 protein]; TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP9 protein] CTD PMID:12203115 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135 		JBrowse link
G Tp53 tumor protein p53 decreases expression ISO sulindac sulfide results in decreased expression of TP53 protein CTD PMID:9192825 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Trip4 thyroid hormone receptor interactor 4 increases expression ISO sulindac sulfide results in increased expression of TRIP4 mRNA CTD PMID:16184548 NCBI chr 8:66,351,861...66,439,679
Ensembl chr 8:66,353,248...66,439,774 		JBrowse link
G Tspan8 tetraspanin 8 decreases expression ISO sulindac sulfide results in decreased expression of TSPAN8 mRNA CTD PMID:16184548 NCBI chr 7:51,444,946...51,479,360
Ensembl chr 7:51,445,074...51,479,356 		JBrowse link
G Tuba4a tubulin, alpha 4A decreases expression ISO sulindac sulfide results in decreased expression of TUBA4A mRNA CTD PMID:12734198 NCBI chr 9:76,709,617...76,714,327
Ensembl chr 9:76,709,614...76,713,918 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO sulindac sulfide results in increased expression of TXNRD1 mRNA CTD PMID:16184548 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
G Uba7 ubiquitin-like modifier activating enzyme 7 decreases expression ISO sulindac sulfide results in decreased expression of UBA7 mRNA CTD PMID:16184548 NCBI chr 8:108,665,289...108,674,097
Ensembl chr 8:108,665,292...108,674,099 		JBrowse link
G Ube2d1 ubiquitin-conjugating enzyme E2D 1 increases expression ISO sulindac sulfide results in increased expression of UBE2D1 mRNA CTD PMID:16184548 NCBI chr20:17,309,315...17,343,770
Ensembl chr20:17,309,315...17,342,295 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases activity
increases expression		 ISO sulindac sulfide results in increased activity of UGT1A1 protein
sulindac sulfide results in increased expression of UGT1A1 mRNA		 CTD PMID:17985343 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Upp1 uridine phosphorylase 1 increases expression ISO sulindac sulfide results in increased expression of UPP1 mRNA CTD PMID:16184548 NCBI chr14:83,809,495...83,829,299
Ensembl chr14:83,809,960...83,829,462 		JBrowse link
G Vmp1 vacuole membrane protein 1 increases expression ISO sulindac sulfide results in increased expression of VMP1 mRNA CTD PMID:12734198 NCBI chr10:71,405,058...71,505,045
Ensembl chr10:71,405,452...71,505,007 		JBrowse link
G Xrcc6 X-ray repair cross complementing 6 increases expression ISO sulindac sulfide results in increased expression of XRCC6 mRNA CTD PMID:12734198 NCBI chr 7:113,542,992...113,563,762
Ensembl chr 7:113,543,057...113,563,762 		JBrowse link
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon multiple interactions
decreases expression		 ISO [sulindac sulfide results in decreased expression of YWHAE protein] which results in increased localization of BAD protein; PPARD protein affects the reaction [sulindac sulfide results in decreased expression of YWHAE protein]; sulindac sulfide promotes the reaction [BAD protein binds to YWHAE protein]
sulindac sulfide results in decreased expression of YWHAE mRNA; sulindac sulfide results in decreased expression of YWHAE protein		 CTD PMID:17409426 PMID:18678619 NCBI chr10:60,584,665...60,622,352
Ensembl chr10:60,584,652...60,671,589 		JBrowse link
sulindac sulfone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b1 aldo-keto reductase family 1 member B1 multiple interactions ISO sulindac sulfone binds to and results in decreased activity of AKR1B1 protein CTD PMID:25532697 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157 		JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 multiple interactions ISO sulindac sulfone binds to and results in decreased activity of AKR1B10 protein CTD PMID:25532697 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 affects phosphorylation
multiple interactions		 ISO
EXP		 sulindac sulfone affects the phosphorylation of AKT1 protein
[Celecoxib co-treated with sulindac sulfone] results in decreased expression of AKT1 protein; [Celecoxib co-treated with sulindac sulfone] results in decreased expression of AKT1 protein modified form		 CTD PMID:15570007 PMID:17908994 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alox15 arachidonate 15-lipoxygenase multiple interactions
increases expression		 ISO 8-(4-chlorophenylthio)guanosine 3',5'-cyclic monophosphorothioate inhibits the reaction [sulindac sulfone results in increased phosphorylation of ALOX15 protein]; GATA6 protein inhibits the reaction [sulindac sulfone results in increased expression of ALOX15 protein]
sulindac sulfone results in increased expression of ALOX15 mRNA; sulindac sulfone results in increased expression of ALOX15 protein		 CTD PMID:11861401 PMID:16166323 NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874 		JBrowse link
G Ar androgen receptor multiple interactions ISO
EXP		 AR protein affects the reaction [sulindac sulfone results in decreased expression of KLK3 protein]; sulindac sulfone results in decreased expression of and results in decreased activity of AR protein
[Celecoxib co-treated with sulindac sulfone] results in decreased expression of AR protein		 CTD PMID:14581372 PMID:17908994 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases response to substance EXP BAK1 results in increased susceptibility to sulindac sulfone CTD PMID:18349538 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 ISO MAP2K1 protein inhibits the reaction [sulindac sulfone results in increased cleavage of and results in increased activity of CASP3 protein]; sulindac sulfone results in increased cleavage of and results in increased activity of CASP3 protein
sulindac sulfone results in increased activity of CASP3 protein		 CTD PMID:11051267 PMID:14555707 PMID:15548677 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 increases activity ISO sulindac sulfone results in increased activity of CASP8 protein CTD PMID:11559570 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions		 ISO
EXP		 sulindac sulfone results in decreased expression of CCND1 mRNA; sulindac sulfone results in decreased expression of CCND1 protein
[Celecoxib co-treated with sulindac sulfone] results in decreased expression of CCND1 protein		 CTD PMID:12392815 PMID:15188006 PMID:17908994 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO sulindac sulfone results in increased expression of CDKN1A mRNA; sulindac sulfone results in increased expression of CDKN1A protein CTD PMID:18593937 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO sulindac sulfone results in increased expression of CDKN1B mRNA; sulindac sulfone results in increased expression of CDKN1B protein CTD PMID:18593937 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
increases expression
decreases expression		 ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sulindac sulfone results in decreased expression of CTNNB1 protein]
sulindac sulfone results in increased expression of CTNNB1 protein		 CTD PMID:10910034 PMID:11602670 PMID:12392815 PMID:14555707 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
increases ubiquitination
increases phosphorylation
decreases phosphorylation
decreases expression		 ISO
EXP		 benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sulindac sulfone results in decreased expression of EGFR protein]; Chloroquine inhibits the reaction [sulindac sulfone results in decreased expression of EGFR protein]
sulindac sulfone results in increased ubiquitination of EGFR protein
[Celecoxib co-treated with sulindac sulfone] results in decreased expression of EGFR protein; [Celecoxib co-treated with sulindac sulfone] results in decreased expression of EGFR protein modified form
sulindac sulfone results in increased phosphorylation of EGFR protein
sulindac sulfone results in decreased phosphorylation of EGFR protein		 CTD PMID:17908994 PMID:20332299 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 decreases expression ISO sulindac sulfone results in decreased expression of ERBB2 protein CTD PMID:20332299 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078 		JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 multiple interactions
decreases expression		 ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sulindac sulfone results in decreased expression of ERBB3 protein] CTD PMID:20332299 NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525 		JBrowse link
G Esr1 estrogen receptor 1 decreases expression ISO sulindac sulfone results in decreased expression of ESR1 mRNA; sulindac sulfone results in decreased expression of ESR1 protein CTD PMID:16740773 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Gata6 GATA binding protein 6 multiple interactions
decreases expression		 ISO GATA6 protein inhibits the reaction [sulindac sulfone results in increased expression of ALOX15 protein]
sulindac sulfone results in decreased expression of GATA6 protein		 CTD PMID:11861401 NCBI chr18:2,188,121...2,219,532
Ensembl chr18:2,188,121...2,219,532 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO sulindac sulfone binds to and results in decreased activity of GSTP1 protein CTD PMID:15300575 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Hint1 histidine triad nucleotide binding protein 1 increases expression ISO sulindac sulfone results in increased expression of HINT1 mRNA; sulindac sulfone results in increased expression of HINT1 protein CTD PMID:18593937 NCBI chr10:38,989,516...38,993,259
Ensembl chr 4:92,100,973...92,101,568 		JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase increases activity
increases expression		 ISO sulindac sulfone results in increased activity of HPGD protein
sulindac sulfone results in increased expression of HPGD mRNA		 CTD PMID:19501039 NCBI chr16:33,986,265...34,024,228
Ensembl chr16:33,986,266...34,024,228 		JBrowse link
G Il24 interleukin 24 increases expression ISO sulindac sulfone results in increased expression of IL24 protein CTD PMID:15713900 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487 		JBrowse link
G Klk1c10 kallikrein 1-related peptidase C10 multiple interactions
decreases expression		 ISO AR protein affects the reaction [sulindac sulfone results in decreased expression of KLK3 protein] CTD PMID:11490238 PMID:14581372 NCBI chr 1:94,402,993...94,407,052
Ensembl chr 1:94,402,993...94,407,052 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 multiple interactions ISO MAP2K1 protein inhibits the reaction [sulindac sulfone results in decreased phosphorylation of MAPK1 protein]; MAP2K1 protein inhibits the reaction [sulindac sulfone results in decreased phosphorylation of MAPK3 protein]; MAP2K1 protein inhibits the reaction [sulindac sulfone results in increased cleavage of and results in increased activity of CASP3 protein] CTD PMID:15548677 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147 		JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 multiple interactions ISO sulindac sulfone results in increased phosphorylation of and results in increased activity of MAP2K4 protein CTD PMID:11051267 NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation		 ISO MAP2K1 protein inhibits the reaction [sulindac sulfone results in decreased phosphorylation of MAPK1 protein] CTD PMID:15548677 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation		 ISO MAP2K1 protein inhibits the reaction [sulindac sulfone results in decreased phosphorylation of MAPK3 protein] CTD PMID:15548677 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases activity ISO sulindac sulfone results in increased activity of MAPK8 protein CTD PMID:11051267 PMID:11278263 PMID:15970671 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mmp7 matrix metallopeptidase 7 decreases expression ISO sulindac sulfone results in decreased expression of MMP7 protein CTD PMID:15725655 NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO sulindac sulfone results in increased degradation of and results in decreased expression of NFKBIA protein CTD PMID:18059344 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Ngfr nerve growth factor receptor increases expression ISO sulindac sulfone results in increased expression of NGFR mRNA; sulindac sulfone results in increased expression of NGFR protein CTD PMID:17447067 NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity
increases expression		 ISO sulindac sulfone results in increased activity of NQO1 protein
sulindac sulfone results in increased expression of NQO1 mRNA		 CTD PMID:17985343 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO sulindac sulfone results in decreased expression of PCNA protein CTD PMID:15570007 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pde2a phosphodiesterase 2A decreases activity
multiple interactions		 ISO sulindac sulfone results in decreased activity of PDE2A protein
sulindac sulfone binds to and results in decreased activity of PDE2A protein		 CTD PMID:10910034 PMID:11602670 NCBI chr 1:155,823,590...155,915,434
Ensembl chr 1:155,813,180...155,915,434 		JBrowse link
G Pde5a phosphodiesterase 5A multiple interactions
decreases activity		 ISO sulindac sulfone binds to and results in decreased activity of PDE5A protein
sulindac sulfone results in decreased activity of PDE5A protein		 CTD PMID:10910034 PMID:11602670 NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701 		JBrowse link
G Pgr progesterone receptor decreases expression ISO sulindac sulfone results in decreased expression of PGR mRNA; sulindac sulfone results in decreased expression of PGR protein CTD PMID:16740773 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression ISO sulindac sulfone results in increased expression of PPARA mRNA CTD PMID:11948457 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Ppard peroxisome proliferator-activated receptor delta increases expression ISO sulindac sulfone results in increased expression of PPARD mRNA CTD PMID:11948457 NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases expression		 ISO [sulindac sulfone results in increased activity of PPARG protein] promotes the reaction [PPARG protein binds to SAT1 enhancer]; PPARG protein promotes the reaction [sulindac sulfone results in increased expression of SAT1 mRNA]
sulindac sulfone results in increased expression of PPARG mRNA		 CTD PMID:11948457 PMID:14506281 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 increases expression ISO sulindac sulfone results in increased expression of PRKG1 protein CTD PMID:11602670 PMID:16731751 NCBI chr 1:228,409,605...229,638,794
Ensembl chr 1:228,408,947...229,639,080 		JBrowse link
G Psca prostate stem cell antigen increases expression ISO sulindac sulfone results in increased expression of PSCA mRNA CTD PMID:16949054 NCBI chr 7:106,598,203...106,603,114
Ensembl chr 7:106,595,284...106,609,746 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases expression EXP sulindac sulfone results in decreased expression of PTGS1 mRNA alternative form CTD PMID:11375891 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression
multiple interactions
increases expression		 ISO
EXP		 sulindac sulfone results in decreased expression of PTGS2 protein
sulindac sulfone results in decreased expression of PTGS2 mRNA
[Celecoxib co-treated with sulindac sulfone] results in decreased expression of PTGS2 protein; Celecoxib promotes the reaction [sulindac sulfone results in decreased expression of PTGS2 protein]
[sulindac sulfone results in decreased expression of PTGS2 protein] which results in decreased chemical synthesis of Dinoprostone
sulindac sulfone results in increased expression of PTGS2 mRNA		 CTD PMID:11118042 PMID:11375891 PMID:11948457 PMID:17908994 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects localization ISO sulindac sulfone affects the localization of RELA protein CTD PMID:18059344 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Sat1 spermidine/spermine N1-acetyl transferase 1 multiple interactions
increases expression		 ISO [sulindac sulfone results in increased activity of PPARG protein] promotes the reaction [PPARG protein binds to SAT1 enhancer]; PPARG protein promotes the reaction [sulindac sulfone results in increased expression of SAT1 mRNA] CTD PMID:14506281 PMID:16262603 NCBI chr  X:40,158,354...40,161,641
Ensembl chr  X:40,157,046...40,196,813 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Celecoxib promotes the reaction [sulindac sulfone results in decreased expression of TNF protein] CTD PMID:17908994 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases activity
increases glucuronidation
increases expression		 ISO sulindac sulfone results in increased activity of UGT1A1 protein
UGT1A1 protein results in increased glucuronidation of sulindac sulfone
sulindac sulfone results in increased expression of UGT1A1 mRNA		 CTD PMID:15843492 PMID:17985343 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of sulindac sulfone CTD PMID:15843492 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases glucuronidation ISO UGT1A4 protein results in increased glucuronidation of sulindac sulfone CTD PMID:15843492 NCBI chr 9:88,762,250...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 increases glucuronidation ISO UGT2B7 protein results in increased glucuronidation of sulindac sulfone CTD PMID:15843492 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604 		JBrowse link
G Vasp vasodilator-stimulated phosphoprotein increases phosphorylation ISO sulindac sulfone results in increased phosphorylation of VASP protein CTD PMID:16166323 NCBI chr 1:78,910,009...78,925,791
Ensembl chr 1:78,910,011...78,925,061 		JBrowse link
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon decreases expression ISO sulindac sulfone results in decreased expression of YWHAE protein CTD PMID:17409426 NCBI chr10:60,584,665...60,622,352
Ensembl chr10:60,584,652...60,671,589 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19817
      biological role 19815
        pharmacological role 19058
          analgesic 14740
            sulindac 787
              nitrosulindac 0
              sulindac sulfide 219
              sulindac sulfone 51
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19789
                    p-block element atom 19789
                      carbon group element atom 19737
                        carbon atom 19733
                          organic molecular entity 19733
                            heteroorganic entity 19492
                              organochalcogen compound 19255
                                organooxygen compound 19172
                                  carbon oxoacid 18641
                                    carboxylic acid 18638
                                      monocarboxylic acid 18008
                                        acetic acid 11055
                                          sulindac 787
                                            nitrosulindac 0
                                            sulindac sulfide 219
                                            sulindac sulfone 51
paths to the root