Mrps9 (mitochondrial ribosomal protein S9) - Rat Genome Database

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Gene: Mrps9 (mitochondrial ribosomal protein S9) Rattus norvegicus
Analyze
Symbol: Mrps9
Name: mitochondrial ribosomal protein S9
RGD ID: 1306558
Description: Predicted to enable RNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in mitochondrion and nucleolus. Predicted to be part of mitochondrial small ribosomal subunit. Orthologous to human MRPS9 (mitochondrial ribosomal protein S9); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 28S ribosomal protein S9, mitochondrial; small ribosomal subunit protein uS9m
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8952,605,678 - 52,664,499 (+)NCBIGRCr8
mRatBN7.2945,113,554 - 45,172,375 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl945,113,554 - 45,172,375 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx953,609,944 - 53,668,782 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0958,732,742 - 58,791,582 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0957,011,402 - 57,070,223 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0949,647,257 - 49,704,828 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl949,647,257 - 49,704,828 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0949,317,820 - 49,375,391 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4942,043,450 - 42,102,684 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1942,044,863 - 42,104,091 (+)NCBI
Celera942,831,629 - 42,890,556 (+)NCBICelera
Cytogenetic Map9q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
translation  (IEA)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:18614015   PMID:22681889  


Genomics

Comparative Map Data
Mrps9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8952,605,678 - 52,664,499 (+)NCBIGRCr8
mRatBN7.2945,113,554 - 45,172,375 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl945,113,554 - 45,172,375 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx953,609,944 - 53,668,782 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0958,732,742 - 58,791,582 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0957,011,402 - 57,070,223 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0949,647,257 - 49,704,828 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl949,647,257 - 49,704,828 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0949,317,820 - 49,375,391 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4942,043,450 - 42,102,684 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1942,044,863 - 42,104,091 (+)NCBI
Celera942,831,629 - 42,890,556 (+)NCBICelera
Cytogenetic Map9q22NCBI
MRPS9
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382105,038,069 - 105,099,960 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2105,038,069 - 105,099,960 (+)EnsemblGRCh38hg38GRCh38
GRCh372105,654,527 - 105,716,418 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362105,020,938 - 105,082,850 (+)NCBINCBI36Build 36hg18NCBI36
Build 342105,113,023 - 105,174,935NCBI
Celera299,857,577 - 99,919,512 (+)NCBICelera
Cytogenetic Map2q12.1NCBI
HuRef299,424,216 - 99,487,359 (+)NCBIHuRef
CHM1_12105,659,619 - 105,720,891 (+)NCBICHM1_1
T2T-CHM13v2.02105,499,329 - 105,561,123 (+)NCBIT2T-CHM13v2.0
Mrps9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39142,890,393 - 42,944,843 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl142,890,393 - 42,944,843 (+)EnsemblGRCm39 Ensembl
GRCm38142,851,233 - 42,905,683 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl142,851,233 - 42,905,683 (+)EnsemblGRCm38mm10GRCm38
MGSCv37142,908,078 - 42,962,528 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36142,795,829 - 42,850,226 (+)NCBIMGSCv36mm8
Celera143,190,035 - 43,244,491 (+)NCBICelera
Cytogenetic Map1BNCBI
cM Map121.62NCBI
Mrps9
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547010,033,028 - 10,087,361 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495547010,033,685 - 10,166,113 (+)NCBIChiLan1.0ChiLan1.0
MRPS9
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21222,613,301 - 22,677,437 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A22,616,066 - 22,677,076 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A96,725,292 - 96,786,113 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A106,129,381 - 106,190,167 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A106,129,381 - 106,194,057 (+)Ensemblpanpan1.1panPan2
MRPS9
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11038,307,233 - 38,369,987 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1038,307,235 - 38,369,885 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1038,232,442 - 38,295,726 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01039,163,383 - 39,226,852 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1039,162,432 - 39,226,264 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11038,887,389 - 38,950,528 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01039,166,715 - 39,230,140 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01039,358,527 - 39,421,975 (-)NCBIUU_Cfam_GSD_1.0
Mrps9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629287,479,252 - 87,536,218 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936764902,316 - 959,120 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936764902,156 - 959,154 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MRPS9
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl349,625,248 - 49,681,440 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1349,626,796 - 49,681,437 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2352,083,605 - 52,092,083 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.2351,870,434 - 51,891,406 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MRPS9
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1148,694,469 - 8,749,754 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl148,694,520 - 8,750,792 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041176,412,092 - 176,467,884 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mrps9
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247499,220,950 - 9,275,953 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247499,220,880 - 9,275,836 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mrps9
384 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:110
Count of miRNA genes:91
Interacting mature miRNAs:96
Transcripts:ENSRNOT00000021899
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9728325252283252Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)9895256053952560Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat
631680Cm11Cardiac mass QTL 113.10.00089heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)92043051965430519Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92207120067071200Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)92213332249968732Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)92375402458157242Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)92375402461381613Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)92746863972468639Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94249534379271511Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat

Markers in Region
BI274476  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2945,166,189 - 45,166,303 (+)MAPPERmRatBN7.2
Rnor_6.0949,698,643 - 49,698,756NCBIRnor6.0
Rnor_5.0949,369,206 - 49,369,319UniSTSRnor5.0
RGSC_v3.4942,096,499 - 42,096,612UniSTSRGSC3.4
Celera942,884,371 - 42,884,484UniSTS
RH 3.4 Map9399.0UniSTS
Cytogenetic Map9q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000021899   ⟹   ENSRNOP00000021899
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl945,113,554 - 45,172,375 (+)Ensembl
Rnor_6.0 Ensembl949,647,257 - 49,704,828 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000094384   ⟹   ENSRNOP00000081112
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl945,113,554 - 45,172,375 (+)Ensembl
RefSeq Acc Id: NM_001100549   ⟹   NP_001094019
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8952,605,678 - 52,664,499 (+)NCBI
mRatBN7.2945,113,554 - 45,172,375 (+)NCBI
Rnor_6.0949,647,257 - 49,704,828 (+)NCBI
Rnor_5.0949,317,820 - 49,375,391 (+)NCBI
RGSC_v3.4942,043,450 - 42,102,684 (+)RGD
Celera942,831,629 - 42,890,556 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001094019 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH88242 (Get FASTA)   NCBI Sequence Viewer  
  AAI58705 (Get FASTA)   NCBI Sequence Viewer  
  EDL99153 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000021899
  ENSRNOP00000021899.5
  ENSRNOP00000081112.1
Reference Protein Sequences
RefSeq Acc Id: NP_001094019   ⟸   NM_001100549
- UniProtKB: B0BN68 (UniProtKB/TrEMBL),   A6INQ7 (UniProtKB/TrEMBL),   A0A8I5ZRA7 (UniProtKB/TrEMBL),   F7FN10 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000021899   ⟸   ENSRNOT00000021899
RefSeq Acc Id: ENSRNOP00000081112   ⟸   ENSRNOT00000094384

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B0BN68-F1-model_v2 AlphaFold B0BN68 1-390 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696637
Promoter ID:EPDNEW_R7162
Type:multiple initiation site
Name:Mrps9_1
Description:mitochondrial ribosomal protein S9
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0949,647,274 - 49,647,334EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306558 AgrOrtholog
BioCyc Gene G2FUF-27679 BioCyc
Ensembl Genes ENSRNOG00000016201 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000021899 ENTREZGENE
  ENSRNOT00000021899.6 UniProtKB/TrEMBL
  ENSRNOT00000094384.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.230.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7366193 IMAGE-MGC_LOAD
  IMAGE:9030006 IMAGE-MGC_LOAD
InterPro Ribosomal_S5_D2-typ_fold UniProtKB/TrEMBL
  Ribosomal_S5_D2-typ_fold_subgr UniProtKB/TrEMBL
  Ribosomal_S9 UniProtKB/TrEMBL
  Ribosomal_S9_CS UniProtKB/TrEMBL
KEGG Report rno:301371 UniProtKB/TrEMBL
MGC_CLONE MGC:109027 IMAGE-MGC_LOAD
  MGC:187794 IMAGE-MGC_LOAD
NCBI Gene 301371 ENTREZGENE
PANTHER 28S RIBOSOMAL PROTEIN S9, MITOCHONDRIAL UniProtKB/TrEMBL
  Ribosomal_S9 UniProtKB/TrEMBL
Pfam Ribosomal_S9 UniProtKB/TrEMBL
PhenoGen Mrps9 PhenoGen
PROSITE RIBOSOMAL_S9 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016201 RatGTEx
Superfamily-SCOP Ribosomal_S5_D2-typ_fold UniProtKB/TrEMBL
UniProt A0A8I5ZRA7 ENTREZGENE, UniProtKB/TrEMBL
  A6INQ7 ENTREZGENE, UniProtKB/TrEMBL
  B0BN68 ENTREZGENE
  F7FN10 ENTREZGENE, UniProtKB/TrEMBL
  Q5I0K4_RAT UniProtKB/TrEMBL
UniProt Secondary B0BN68 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Mrps9  mitochondrial ribosomal protein S9  Mrps9_predicted  mitochondrial ribosomal protein S9 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Mrps9_predicted  mitochondrial ribosomal protein S9 (predicted)      Symbol and Name status set to approved 70820 APPROVED