Cnot6 (CCR4-NOT transcription complex, subunit 6) - Rat Genome Database

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Gene: Cnot6 (CCR4-NOT transcription complex, subunit 6) Rattus norvegicus
Analyze
Symbol: Cnot6
Name: CCR4-NOT transcription complex, subunit 6
RGD ID: 1310783
Description: Predicted to enable nuclear receptor coactivator activity and poly(A)-specific ribonuclease activity. Predicted to be involved in nuclear-transcribed mRNA catabolic process; positive regulation of cell population proliferation; and positive regulation of cytoplasmic mRNA processing body assembly. Predicted to be part of CCR4-NOT complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human CNOT6 (CCR4-NOT transcription complex subunit 6); PARTICIPATES IN microRNA pathway; RNA degradation pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2-methoxyethanol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: carbon catabolite repressor protein 4 homolog; CCR4; CCR4 carbon catabolite repression 4-like; CCR4-NOT transcription complex subunit 6; cytoplasmic deadenylase; LOC287249; RGD1310783; similar to CCR4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81034,479,892 - 34,532,166 (-)NCBIGRCr8
mRatBN7.21033,978,785 - 34,031,025 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1033,980,831 - 34,031,025 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1038,654,389 - 38,706,577 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0107,192,793 - 7,244,987 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01033,648,051 - 33,700,236 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01035,144,291 - 35,195,126 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1035,146,337 - 35,187,416 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01034,916,148 - 34,967,236 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41035,139,386 - 35,192,631 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11035,140,437 - 35,193,680 (-)NCBI
Celera1033,337,338 - 33,387,801 (-)NCBICelera
Cytogenetic Map10q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
CCR4-NOT complex  (IBA,IEA,ISO,ISS)
cytoplasm  (IBA,IEA)
nucleus  (IBA,IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Comprehensive gene review and curation RGD comprehensive gene curation
6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
7. RNA decay machines: deadenylation by the Ccr4-not and Pan2-Pan3 complexes. Wahle E and Winkler GS, Biochim Biophys Acta. 2013 Jun-Jul;1829(6-7):561-70. doi: 10.1016/j.bbagrm.2013.01.003. Epub 2013 Jan 19.
Additional References at PubMed
PMID:11889047   PMID:15314026   PMID:15489334   PMID:18180299   PMID:18377426   PMID:19558367   PMID:19946888   PMID:20065043   PMID:20595389   PMID:21233283  


Genomics

Comparative Map Data
Cnot6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81034,479,892 - 34,532,166 (-)NCBIGRCr8
mRatBN7.21033,978,785 - 34,031,025 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1033,980,831 - 34,031,025 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1038,654,389 - 38,706,577 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0107,192,793 - 7,244,987 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01033,648,051 - 33,700,236 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01035,144,291 - 35,195,126 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1035,146,337 - 35,187,416 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01034,916,148 - 34,967,236 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41035,139,386 - 35,192,631 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11035,140,437 - 35,193,680 (-)NCBI
Celera1033,337,338 - 33,387,801 (-)NCBICelera
Cytogenetic Map10q21NCBI
CNOT6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385180,494,379 - 180,578,358 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5180,494,379 - 180,578,358 (+)EnsemblGRCh38hg38GRCh38
GRCh375179,921,379 - 180,005,358 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365179,854,023 - 179,937,959 (+)NCBINCBI36Build 36hg18NCBI36
Build 345179,854,022 - 179,937,959NCBI
Celera5175,544,212 - 175,628,139 (+)NCBICelera
Cytogenetic Map5q35.3NCBI
HuRef5174,644,736 - 174,728,395 (+)NCBIHuRef
CHM1_15179,353,628 - 179,437,772 (+)NCBICHM1_1
T2T-CHM13v2.05181,050,244 - 181,134,238 (+)NCBIT2T-CHM13v2.0
Cnot6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391149,562,324 - 49,604,227 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1149,562,330 - 49,603,550 (-)EnsemblGRCm39 Ensembl
GRCm381149,671,497 - 49,713,401 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1149,671,503 - 49,712,723 (-)EnsemblGRCm38mm10GRCm38
MGSCv371149,488,200 - 49,526,212 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361149,518,121 - 49,556,133 (-)NCBIMGSCv36mm8
Celera1154,236,493 - 54,264,486 (-)NCBICelera
Cytogenetic Map11B1.2NCBI
cM Map1129.76NCBI
Cnot6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955408170,399 - 218,040 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955408170,399 - 239,492 (-)NCBIChiLan1.0ChiLan1.0
CNOT6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24175,515,935 - 175,600,656 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15173,680,001 - 173,764,349 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05175,695,802 - 175,780,534 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15183,007,081 - 183,089,997 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5183,007,081 - 183,089,997 (+)Ensemblpanpan1.1panPan2
CNOT6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1111,209,732 - 1,277,435 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl111,212,546 - 1,270,997 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha111,269,212 - 1,339,152 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0111,178,390 - 1,248,363 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl111,180,825 - 1,248,445 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1111,131,330 - 1,201,268 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0111,229,391 - 1,299,325 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0111,469,405 - 1,539,355 (-)NCBIUU_Cfam_GSD_1.0
Cnot6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213119,100,828 - 119,174,587 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936739307,916 - 385,145 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936739308,117 - 384,600 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CNOT6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl278,132,939 - 78,202,492 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1278,131,236 - 78,202,518 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2279,564,705 - 79,635,537 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CNOT6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12382,218,170 - 82,303,552 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2382,218,180 - 82,303,849 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607513,637,452 - 13,723,808 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cnot6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473343,138,758 - 43,187,791 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473343,137,751 - 43,195,004 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cnot6
221 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:176
Count of miRNA genes:136
Interacting mature miRNAs:150
Transcripts:ENSRNOT00000003752
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101790711351786432Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
631531Iresp2Immunoglobin response QTL26.3blood immunoglobulin E amount (VT:0002492)serum immunoglobulin E level (CMO:0002101)102291826836400810Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)102795762634490668Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102887565052200160Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat

Markers in Region
RH142065  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21034,026,710 - 34,026,914 (+)MAPPERmRatBN7.2
Rnor_6.01035,190,812 - 35,191,015NCBIRnor6.0
Rnor_5.01034,962,922 - 34,963,125UniSTSRnor5.0
RGSC_v3.41035,188,317 - 35,188,520UniSTSRGSC3.4
Celera1033,383,481 - 33,383,684UniSTS
RH 3.4 Map10356.4UniSTS
Cytogenetic Map10q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 35 57 41 19 41 2 2 74 35 41 11 2
Low 8 6 9 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000078960   ⟹   ENSRNOP00000075273
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1033,980,831 - 34,015,180 (-)Ensembl
Rnor_6.0 Ensembl1035,148,022 - 35,175,647 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000084509   ⟹   ENSRNOP00000074431
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1033,980,831 - 34,031,025 (-)Ensembl
Rnor_6.0 Ensembl1035,146,337 - 35,187,416 (-)Ensembl
RefSeq Acc Id: NM_001393878   ⟹   NP_001380807
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81034,479,894 - 34,532,126 (-)NCBI
mRatBN7.21033,978,787 - 34,031,025 (-)NCBI
RefSeq Acc Id: NR_172026
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81034,479,894 - 34,532,126 (-)NCBI
mRatBN7.21033,978,787 - 34,031,025 (-)NCBI
RefSeq Acc Id: XM_039085374   ⟹   XP_038941302
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81034,479,892 - 34,522,479 (-)NCBI
mRatBN7.21033,978,785 - 34,021,378 (-)NCBI
RefSeq Acc Id: XM_039085376   ⟹   XP_038941304
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81034,479,892 - 34,522,479 (-)NCBI
mRatBN7.21033,978,785 - 34,021,378 (-)NCBI
RefSeq Acc Id: XM_063268575   ⟹   XP_063124645
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81034,479,892 - 34,532,147 (-)NCBI
RefSeq Acc Id: XM_063268576   ⟹   XP_063124646
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81034,479,892 - 34,532,166 (-)NCBI
RefSeq Acc Id: XM_063268577   ⟹   XP_063124647
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81034,479,892 - 34,532,149 (-)NCBI
RefSeq Acc Id: XM_063268578   ⟹   XP_063124648
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81034,479,892 - 34,497,099 (-)NCBI
RefSeq Acc Id: XM_063268580   ⟹   XP_063124650
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81034,479,892 - 34,497,099 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000074431   ⟸   ENSRNOT00000084509
RefSeq Acc Id: ENSRNOP00000075273   ⟸   ENSRNOT00000078960
RefSeq Acc Id: XP_038941304   ⟸   XM_039085376
- Peptide Label: isoform X2
- UniProtKB: A6HDX6 (UniProtKB/TrEMBL),   A0A0G2KA59 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038941302   ⟸   XM_039085374
- Peptide Label: isoform X1
- UniProtKB: Q6AXU9 (UniProtKB/Swiss-Prot),   A0A0G2K816 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001380807   ⟸   NM_001393878
- UniProtKB: Q6AXU9 (UniProtKB/Swiss-Prot),   A0A0G2K816 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063124646   ⟸   XM_063268576
- Peptide Label: isoform X2
- UniProtKB: A6HDX6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063124647   ⟸   XM_063268577
- Peptide Label: isoform X2
- UniProtKB: A6HDX6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063124645   ⟸   XM_063268575
- Peptide Label: isoform X1
- UniProtKB: Q6AXU9 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063124648   ⟸   XM_063268578
- Peptide Label: isoform X3
- UniProtKB: A6HDX8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063124650   ⟸   XM_063268580
- Peptide Label: isoform X3
- UniProtKB: A6HDX8 (UniProtKB/TrEMBL)
Protein Domains
Endonuclease/exonuclease/phosphatase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6AXU9-F1-model_v2 AlphaFold Q6AXU9 1-557 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310783 AgrOrtholog
BioCyc Gene G2FUF-25279 BioCyc
Ensembl Genes ENSRNOG00000054891 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055018479 UniProtKB/Swiss-Prot
  ENSRNOG00060018615 UniProtKB/Swiss-Prot
  ENSRNOG00065006026 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000078960 ENTREZGENE
  ENSRNOT00000078960.2 UniProtKB/TrEMBL
  ENSRNOT00000084509 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000084509.2 UniProtKB/Swiss-Prot
  ENSRNOT00055031424 UniProtKB/Swiss-Prot
  ENSRNOT00060032075 UniProtKB/Swiss-Prot
  ENSRNOT00065009118 UniProtKB/Swiss-Prot
Gene3D-CATH 3.60.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7134677 IMAGE-MGC_LOAD
InterPro Cnot6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Endo/exonu/phosph_ase_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Endo/exonuclease/phosphatase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt_4 UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:287249 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94449 IMAGE-MGC_LOAD
NCBI Gene 287249 ENTREZGENE
PANTHER CARBON CATABOLITE REPRESSOR PROTEIN 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Exo_endo_phos UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_4 UniProtKB/TrEMBL
  LRR_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cnot6 PhenoGen
PROSITE LRR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000054891 RatGTEx
  ENSRNOG00055018479 RatGTEx
  ENSRNOG00060018615 RatGTEx
  ENSRNOG00065006026 RatGTEx
SMART LRR_TYP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56219 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K816 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2KA59 ENTREZGENE, UniProtKB/TrEMBL
  A6HDX5_RAT UniProtKB/TrEMBL
  A6HDX6 ENTREZGENE, UniProtKB/TrEMBL
  A6HDX8 ENTREZGENE, UniProtKB/TrEMBL
  CNOT6_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-27 Cnot6  CCR4-NOT transcription complex, subunit 6  RGD1310783  similar to CCR4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1310783  similar to CCR4  RGD1310783_predicted  similar to CCR4 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1310783_predicted  similar to CCR4 (predicted)  LOC287249_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC287249_predicted  similar to CCR4 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL