| 1,4-phenylenediamine | affects response to substance | ISO | RGD:732527 | 6480464 | NAT2 gene polymorphism affects the susceptibility to 4-phenylenediamine | CTD | PMID:16533241 |
| 17beta-estradiol | decreases expression | ISO | RGD:732527 | 6480464 | Estradiol results in decreased expression of NAT2 mRNA | CTD | PMID:20106945 |
| 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:732527 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of NAT2 mRNA | CTD | PMID:19684285 |
| 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:735739 | 6480464 | Tetrachlorodibenzodioxin affects the expression of NAT2 mRNA | CTD | PMID:21570461 |
| 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:735739 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of NAT2 mRNA | CTD | PMID:18434241 PMID:19933214 |
| 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:735739 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of NAT2 mRNA | CTD | PMID:19933214 PMID:18434241 |
| 2-acetamidofluorene | increases activity | ISO | RGD:732527 | 6480464 | NAT2 protein results in increased activity of 2-Acetylaminofluorene | CTD | PMID:15450435 |
| 2-naphthylamine | increases activity | ISO | RGD:732527 | 6480464 | NAT2 protein results in increased activity of 2-Naphthylamine | CTD | PMID:15450435 |
| 3'-phospho-5'-adenylyl sulfate | multiple interactions | ISO | RGD:732527 | 6480464 | [NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[SULT1A2 protein co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone] | CTD | PMID:20545351 |
| 3,4-dichloroaniline | increases acetylation | ISO | RGD:732527 | 6480464 | NAT2 protein results in increased acetylation of 3,4-dichloroaniline | CTD | PMID:15627487 |
| 4,4'-diaminodiphenylmethane | affects acetylation | EXP | | 6480464 | NAT2 gene polymorphism affects the acetylation of 4,4'-diaminodiphenylmethane | CTD | PMID:16192314 |
| 4,4'-diaminodiphenylmethane | increases acetylation | EXP | | 6480464 | NAT2 protein results in increased acetylation of 4,4'-diaminodiphenylmethane | CTD | PMID:16192314 |
| 4,4'-diaminodiphenylmethane | increases response to substance | EXP | | 6480464 | NAT2 gene polymorphism results in increased susceptibility to 4,4'-diaminodiphenylmethane | CTD | PMID:16192314 |
| 4-aminobenzoic acid | increases acetylation | ISO | RGD:735739 | 6480464 | NAT2 protein results in increased acetylation of 4-Aminobenzoic Acid | CTD | PMID:15627487 |
| 4-aminobenzoic acid | increases acetylation | EXP | | 6480464 | NAT2 protein results in increased acetylation of 4-Aminobenzoic Acid | CTD | PMID:18842621 |
| 4-aminobenzoic acid | multiple interactions | EXP | | 6480464 | 4-biphenylamine inhibits the reaction [NAT2 protein results in increased acetylation of 4-Aminobenzoic Acid] | CTD | PMID:18842621 |
| 4-aminosalicylic acid | multiple interactions | ISO | RGD:735739 | 6480464 | [Peroxynitrous Acid results in decreased activity of NAT2 protein] which results in decreased acetylation of Aminosalicylic Acid | CTD | PMID:19248797 |
| 4-chloroaniline | increases acetylation | ISO | RGD:732527 | 6480464 | NAT2 protein results in increased acetylation of 4-chloroaniline | CTD | PMID:15627487 |
| acetyl-CoA | multiple interactions | ISO | RGD:732527 | 6480464 | [NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[SULT1A2 protein co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone]; more ... | CTD | PMID:20545351 |
| acetylsalicylic acid | affects response to substance | ISO | RGD:732527 | 6480464 | NAT2 polymorphism affects the susceptibility to Aspirin | CTD | PMID:20602614 |
| aflatoxin B1 | multiple interactions | ISO | RGD:732527 | 6480464 | [CYP3A7 co-treated with NAT2] results in increased susceptibility to Aflatoxin B1 | CTD | PMID:7625840 |
| aflatoxin B1 | decreases expression | ISO | RGD:732527 | 6480464 | Aflatoxin B1 results in decreased expression of NAT2 mRNA | CTD | PMID:22100608 |
| ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of NAT2 mRNA | CTD | PMID:16483693 |
| aniline | increases acetylation | ISO | RGD:732527 | 6480464 | NAT2 protein results in increased acetylation of aniline | CTD | PMID:15627487 |
| asbestos | affects response to substance | ISO | RGD:732527 | 6480464 | NAT2 protein polymorphism affects the susceptibility to Asbestos | CTD | PMID:15993904 |
| benzene | increases response to substance | ISO | RGD:732527 | 6480464 | NAT2 gene polymorphism results in increased susceptibility to Benzene | CTD | PMID:15226677 |
| benzene | affects response to substance | ISO | RGD:732527 | 6480464 | NAT2 gene polymorphism affects the susceptibility to Benzene | CTD | PMID:15226677 |
| benzene | affects metabolic processing | ISO | RGD:732527 | 6480464 | NAT2 protein affects the metabolism of Benzene | CTD | PMID:15226677 |
| benzo[a]pyrene | multiple interactions | ISO | RGD:735739 | 6480464 | [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in increased expression of NAT2 mRNA | CTD | PMID:21715664 |
| benzo[a]pyrene | increases expression | ISO | RGD:735739 | 6480464 | Benzo(a)pyrene results in increased expression of NAT2 mRNA | CTD | PMID:21715664 |
| biphenyl-4-amine | multiple interactions | EXP | | 6480464 | 4-biphenylamine inhibits the reaction [NAT2 protein results in increased acetylation of 2-aminofluorene]; more ... | CTD | PMID:18842621 |
| biphenyl-4-amine | increases acetylation | ISO | RGD:732527 | 6480464 | NAT2 protein results in increased acetylation of 4-biphenylamine | CTD | PMID:12222688 |
| biphenyl-4-amine | increases metabolic processing | ISO | RGD:735739 | 6480464 | NAT2 protein results in increased metabolism of 4-biphenylamine | CTD | PMID:16857729 PMID:16815960 |
| biphenyl-4-amine | increases activity | ISO | RGD:732527 | 6480464 | NAT2 protein results in increased activity of 4-biphenylamine | CTD | PMID:15450435 |
| biphenyl-4-amine | increases metabolic processing | ISO | RGD:735739 | 6480464 | NAT2 protein results in increased metabolism of 4-biphenylamine | CTD | PMID:16815960 PMID:16857729 |
| biphenyl-4-amine | decreases activity | EXP | | 6480464 | 4-biphenylamine results in decreased activity of NAT2 protein | CTD | PMID:18842621 |
| biphenyl-4-amine | increases acetylation | EXP | | 6480464 | NAT2 protein results in increased acetylation of 4-biphenylamine | CTD | PMID:18842621 |
| bisphenol A | multiple interactions | ISO | RGD:735739 | 6480464 | bisphenol A binds to and results in decreased activity of NAT2 protein | CTD | PMID:18280460 |
| cadmium dichloride | multiple interactions | ISO | RGD:732527 | 6480464 | Cadmium Chloride binds to and results in decreased activity of NAT2 protein | CTD | PMID:20810355 |
| cadmium dichloride | multiple interactions | ISO | RGD:735739 | 6480464 | [Cadmium Chloride results in decreased activity of NAT2 protein] which affects the acetylation of 2-aminofluorene | CTD | PMID:20810355 |
| cadmium dichloride | decreases activity | ISO | RGD:735739 | 6480464 | Cadmium Chloride results in decreased activity of NAT2 protein | CTD | PMID:20810355 |
| caffeine | affects metabolic processing | ISO | RGD:732527 | 6480464 | NAT2 protein affects the metabolism of Caffeine | CTD | PMID:15199075 more ... |
| caffeine | affects metabolic processing | ISO | RGD:732527 | 6480464 | NAT2 protein affects the metabolism of Caffeine | CTD | PMID:14586384 more ... |
| caffeine | affects metabolic processing | ISO | RGD:732527 | 6480464 | NAT2 protein affects the metabolism of Caffeine | CTD | PMID:15327588 more ... |
| caffeine | affects metabolic processing | ISO | RGD:732527 | 6480464 | NAT2 protein affects the metabolism of Caffeine | CTD | PMID:14747882 more ... |
| caffeine | affects metabolic processing | ISO | RGD:732527 | 6480464 | NAT2 protein affects the metabolism of Caffeine | CTD | PMID:14747882 more ... |
| caffeine | increases acetylation | ISO | RGD:732527 | 6480464 | NAT2 protein results in increased acetylation of Caffeine | CTD | PMID:15558239 |
| caffeine | affects metabolic processing | ISO | RGD:732527 | 6480464 | NAT2 protein affects the metabolism of Caffeine | CTD | PMID:14747882 more ... |
| caffeine | affects metabolic processing | ISO | RGD:732527 | 6480464 | NAT2 protein affects the metabolism of Caffeine | CTD | PMID:14747882 more ... |
| calcitriol | increases expression | ISO | RGD:732527 | 6480464 | Calcitriol results in increased expression of NAT2 mRNA | CTD | PMID:21592394 |
| calcitriol | multiple interactions | ISO | RGD:732527 | 6480464 | [Testosterone co-treated with Calcitriol] results in increased expression of NAT2 mRNA | CTD | PMID:21592394 |
| carbamazepine | increases expression | ISO | RGD:732527 | 6480464 | Carbamazepine results in increased expression of NAT2 mRNA | CTD | PMID:17112801 |
| carotenoid | affects response to substance | ISO | RGD:732527 | 6480464 | NAT2 protein polymorphism affects the susceptibility to Carotenoids | CTD | PMID:15095308 |
| chlorzoxazone | affects metabolic processing | ISO | RGD:732527 | 6480464 | NAT2 protein affects the metabolism of Chlorzoxazone | CTD | PMID:14586387 |
| cyclosporin A | decreases expression | ISO | RGD:732527 | 6480464 | Cyclosporine results in decreased expression of NAT2 mRNA | CTD | PMID:20106945 |
| cyclosporin A | decreases expression | ISO | RGD:735739 | 6480464 | Cyclosporine results in decreased expression of NAT2 mRNA | CTD | PMID:19770486 |
| dapsone | increases acetylation | ISO | RGD:732527 | 6480464 | NAT2 protein results in increased acetylation of Dapsone | CTD | PMID:14528063 |
| dextromethorphan | affects metabolic processing | ISO | RGD:732527 | 6480464 | NAT2 protein affects the metabolism of Dextromethorphan | CTD | PMID:15199075 |
| diepoxybutane | decreases response to substance | ISO | RGD:732527 | 6480464 | NAT2 gene polymorphism results in decreased susceptibility to erythritol anhydride | CTD | PMID:17078101 |
| diethylstilbestrol | decreases activity | ISO | RGD:735739 | 6480464 | Diethylstilbestrol results in decreased activity of NAT2 protein | CTD | PMID:18280460 |
| diphenylmethane-4,4'-diisocyanate | increases response to substance | ISO | RGD:732527 | 6480464 | NAT2 protein polymorphism results in increased susceptibility to 4,4'-diphenylmethane diisocyanate | CTD | PMID:11927838 |
| genistein | decreases activity | ISO | RGD:735739 | 6480464 | Genistein results in decreased activity of NAT2 protein | CTD | PMID:18280460 |
| hexamethylene diisocyanate | increases response to substance | ISO | RGD:732527 | 6480464 | NAT2 protein polymorphism results in increased susceptibility to 1,6-hexamethylene diisocyanate | CTD | PMID:11927838 |
| hydralazine | affects metabolic processing | ISO | RGD:732527 | 6480464 | NAT2 protein affects the metabolism of Hydralazine | CTD | PMID:15627487 |
| hydralazine | increases acetylation | ISO | RGD:732527 | 6480464 | NAT2 protein results in increased acetylation of Hydralazine | CTD | PMID:15627487 |
| hydrogen peroxide | decreases activity | ISO | RGD:732527 | 6480464 | Hydrogen Peroxide results in decreased activity of NAT2 protein | CTD | PMID:15644493 |
| hydrogen peroxide | decreases activity | ISO | RGD:735739 | 6480464 | Hydrogen Peroxide results in decreased activity of NAT2 protein | CTD | PMID:19248797 |
| isoniazide | affects response to substance | ISO | RGD:732527 | 6480464 | NAT2 gene polymorphism affects the susceptibility to Isoniazid | CTD | PMID:20485159 more ... |
| isoniazide | increases metabolic processing | ISO | RGD:732527 | 6480464 | NAT2 protein results in increased metabolism of Isoniazid | CTD | PMID:16531626 more ... |
| isoniazide | affects response to substance | ISO | RGD:732527 | 6480464 | NAT2 gene polymorphism affects the susceptibility to Isoniazid | CTD | PMID:11379777 more ... |
| isoniazide | affects response to substance | ISO | RGD:732527 | 6480464 | NAT2 gene polymorphism affects the susceptibility to Isoniazid | CTD | PMID:11915035 more ... |
| isoniazide | affects response to substance | ISO | RGD:732527 | 6480464 | NAT2 gene polymorphism affects the susceptibility to Isoniazid | CTD | PMID:11915035 more ... |
| isoniazide | increases metabolic processing | ISO | RGD:732527 | 6480464 | NAT2 protein results in increased metabolism of Isoniazid | CTD | PMID:17509624 more ... |
| isoniazide | affects response to substance | ISO | RGD:732527 | 6480464 | NAT2 gene polymorphism affects the susceptibility to Isoniazid | CTD | PMID:11915035 more ... |
| isoniazide | increases acetylation | ISO | RGD:732527 | 6480464 | NAT2 protein results in increased acetylation of Isoniazid | CTD | PMID:11379777 more ... |
| isoniazide | affects response to substance | ISO | RGD:732527 | 6480464 | NAT2 gene polymorphism affects the susceptibility to Isoniazid | CTD | PMID:15618686 more ... |
| isoniazide | increases acetylation | ISO | RGD:732527 | 6480464 | NAT2 protein results in increased acetylation of Isoniazid | CTD | PMID:11379777 more ... |
| isoniazide | increases metabolic processing | ISO | RGD:732527 | 6480464 | NAT2 protein results in increased metabolism of Isoniazid | CTD | PMID:16847467 more ... |
| isoniazide | affects metabolic processing | ISO | RGD:732527 | 6480464 | NAT2 protein polymorphism affects the metabolism of Isoniazid | CTD | PMID:15908628 PMID:15546075 |
| isoniazide | affects response to substance | ISO | RGD:732527 | 6480464 | NAT2 gene polymorphism affects the susceptibility to Isoniazid | CTD | PMID:15618686 more ... |
| isoniazide | increases metabolic processing | ISO | RGD:732527 | 6480464 | NAT2 protein results in increased metabolism of Isoniazid | CTD | PMID:16847467 more ... |
| isoniazide | increases acetylation | ISO | RGD:732527 | 6480464 | NAT2 protein results in increased acetylation of Isoniazid | CTD | PMID:15565348 more ... |
| isoniazide | affects metabolic processing | ISO | RGD:732527 | 6480464 | NAT2 protein polymorphism affects the metabolism of Isoniazid | CTD | PMID:15546075 PMID:15908628 |
| isoniazide | increases acetylation | ISO | RGD:732527 | 6480464 | NAT2 protein polymorphism results in increased acetylation of Isoniazid | CTD | PMID:17973219 |
| isoniazide | affects metabolic processing | ISO | RGD:732527 | 6480464 | NAT2 protein affects the metabolism of Isoniazid | CTD | PMID:15627487 |
| mesalamine | increases acetylation | ISO | RGD:732527 | 6480464 | NAT2 protein results in increased acetylation of Mesalamine | CTD | PMID:15627487 |
| N-hydroxy-2-acetamidofluorene | decreases activity | ISO | RGD:732527 | 6480464 | Hydroxyacetylaminofluorene results in decreased activity of NAT2 protein | CTD | PMID:19842618 |
| N-hydroxy-4-acetylaminobiphenyl | decreases activity | ISO | RGD:732527 | 6480464 | N-hydroxy-4-acetylaminobiphenyl results in decreased activity of NAT2 protein | CTD | PMID:19842618 |
| N-hydroxy-4-aminobiphenyl | increases metabolic processing | ISO | RGD:735739 | 6480464 | NAT2 protein results in increased metabolism of N-hydroxy-4-aminobiphenyl | CTD | PMID:16857729 |
| N-nitrosodiethylamine | increases expression | EXP | | 6480464 | Diethylnitrosamine results in increased expression of NAT2 mRNA | CTD | PMID:11323195 |
| NADP zwitterion | multiple interactions | ISO | RGD:732527 | 6480464 | [NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[NQO1 protein co-treated with NADP] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone] | CTD | PMID:20545351 |
| NADP(+) | multiple interactions | ISO | RGD:732527 | 6480464 | [NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[NQO1 protein co-treated with NADP] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone] | CTD | PMID:20545351 |
| paracetamol | affects expression | ISO | RGD:735739 | 6480464 | Acetaminophen affects the expression of NAT2 mRNA | CTD | PMID:17562736 |
| paracetamol | decreases expression | ISO | RGD:732527 | 6480464 | Acetaminophen results in decreased expression of NAT2 mRNA | CTD | PMID:21420995 |
| paracetamol | decreases expression | ISO | RGD:735739 | 6480464 | Acetaminophen results in decreased expression of NAT2 mRNA | CTD | PMID:18544908 |
| perfluorooctanoic acid | multiple interactions | ISO | RGD:735739 | 6480464 | [perfluorooctanoic acid co-treated with PPARA] results in increased expression of NAT2 mRNA | CTD | PMID:20118188 |
| perfluorooctanoic acid | decreases expression | ISO | RGD:735739 | 6480464 | perfluorooctanoic acid results in decreased expression of NAT2 mRNA | CTD | PMID:20118188 |
| peroxynitrous acid | decreases activity | ISO | RGD:732527 | 6480464 | Peroxynitrous Acid results in decreased activity of NAT2 protein | CTD | PMID:15644493 |
| peroxynitrous acid | multiple interactions | ISO | RGD:735739 | 6480464 | [Peroxynitrous Acid results in decreased activity of NAT2 protein] which results in decreased acetylation of Aminosalicylic Acid | CTD | PMID:19248797 |
| peroxynitrous acid | decreases activity | ISO | RGD:735739 | 6480464 | Peroxynitrous Acid results in decreased activity of NAT2 protein | CTD | PMID:19248797 |
| phenylhydrazine | increases acetylation | ISO | RGD:732527 | 6480464 | NAT2 protein results in increased acetylation of phenylhydrazine | CTD | PMID:15627487 |
| procainamide | affects acetylation | ISO | RGD:732527 | 6480464 | NAT2 protein affects the acetylation of Procainamide | CTD | PMID:15930747 |
| silicon dioxide | decreases expression | ISO | RGD:735739 | 6480464 | Silicon Dioxide results in decreased expression of NAT2 mRNA | CTD | PMID:19073995 |
| sulfadiazine | increases acetylation | ISO | RGD:732527 | 6480464 | NAT2 protein results in increased acetylation of Sulfadiazine | CTD | PMID:15843491 |
| sulfamethazine | increases acetylation | ISO | RGD:732527 | 6480464 | NAT2 protein results in increased acetylation of Sulfamethazine | CTD | PMID:15627487 PMID:15880531 |
| sulfamethazine | increases acetylation | ISO | RGD:732527 | 6480464 | NAT2 protein results in increased acetylation of Sulfamethazine | CTD | PMID:12222688 more ... |
| sulfamethazine | increases acetylation | ISO | RGD:732527 | 6480464 | NAT2 protein results in increased acetylation of Sulfamethazine | CTD | PMID:15627487 more ... |
| sulfamethazine | increases acetylation | ISO | RGD:732527 | 6480464 | NAT2 protein results in increased acetylation of Sulfamethazine | CTD | PMID:15880531 PMID:15627487 |
| sulfamethoxazole | increases metabolic processing | ISO | RGD:732527 | 6480464 | NAT2 protein results in increased metabolism of Sulfamethoxazole | CTD | PMID:16847467 |
| sulfapyridine | affects acetylation | ISO | RGD:732527 | 6480464 | NAT2 gene polymorphism affects the acetylation of Sulfapyridine | CTD | PMID:18167504 |
| sulfapyridine | increases acetylation | ISO | RGD:732527 | 6480464 | NAT2 protein results in increased acetylation of Sulfapyridine | CTD | PMID:18167504 |
| sulfasalazine | affects metabolic processing | ISO | RGD:732527 | 6480464 | NAT2 gene polymorphism affects the metabolism of Sulfasalazine | CTD | PMID:19560446 |
| sulfasalazine | affects response to substance | ISO | RGD:732527 | 6480464 | NAT2 protein affects the susceptibility to Sulfasalazine | CTD | PMID:17377643 more ... |
| sulfasalazine | affects response to substance | ISO | RGD:732527 | 6480464 | NAT2 protein affects the susceptibility to Sulfasalazine | CTD | PMID:15032315 more ... |
| sulfasalazine | affects response to substance | ISO | RGD:732527 | 6480464 | NAT2 protein affects the susceptibility to Sulfasalazine | CTD | PMID:17502830 more ... |
| sulfasalazine | affects response to substance | ISO | RGD:732527 | 6480464 | NAT2 protein affects the susceptibility to Sulfasalazine | CTD | PMID:15032315 more ... |
| sulfasalazine | increases acetylation | ISO | RGD:732527 | 6480464 | NAT2 protein results in increased acetylation of Sulfasalazine | CTD | PMID:12465141 |
| sulfasalazine | increases metabolic processing | ISO | RGD:732527 | 6480464 | NAT2 protein results in increased metabolism of Sulfasalazine | CTD | PMID:19560446 |
| sulfasalazine | affects response to substance | ISO | RGD:732527 | 6480464 | NAT2 protein affects the susceptibility to Sulfasalazine | CTD | PMID:17502830 more ... |
| sulfasalazine | affects metabolic processing | ISO | RGD:732527 | 6480464 | NAT2 protein affects the metabolism of Sulfasalazine; more ... | CTD | PMID:15032315 |
| tamoxifen | decreases activity | ISO | RGD:735739 | 6480464 | Tamoxifen results in decreased activity of NAT2 protein | CTD | PMID:18280460 |
| testosterone | increases expression | ISO | RGD:732527 | 6480464 | Testosterone results in increased expression of NAT2 mRNA | CTD | PMID:21592394 |
| testosterone | multiple interactions | ISO | RGD:732527 | 6480464 | [Testosterone co-treated with Calcitriol] results in increased expression of NAT2 mRNA | CTD | PMID:21592394 |
| toluene 2,4-diisocyanate | increases response to substance | ISO | RGD:732527 | 6480464 | NAT2 protein polymorphism results in increased susceptibility to Toluene 2,4-Diisocyanate | CTD | PMID:11927838 |
| trichloroethene | increases response to substance | ISO | RGD:732527 | 6480464 | NAT2 gene polymorphism results in increased susceptibility to Trichloroethylene | CTD | PMID:19834256 |
| trichloroethene | decreases expression | ISO | RGD:735739 | 6480464 | Trichloroethylene results in decreased expression of NAT2 mRNA | CTD | PMID:19448997 |