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Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17alpha-ethynylestradiol | decreases expression | ISO | RGD:736553 | 6480464 | Ethinyl Estradiol results in decreased expression of PPT1 mRNA | CTD | PMID:17555576 | 3H-1,2-dithiole-3-thione | decreases expression | EXP | | 6480464 | 1,2-dithiol-3-thione results in decreased expression of PPT1 mRNA | CTD | PMID:19162173 | 4,4'-diaminodiphenylmethane | increases expression | ISO | RGD:736553 | 6480464 | 4,4'-diaminodiphenylmethane results in increased expression of PPT1 mRNA | CTD | PMID:18648102 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of PPT1 mRNA | CTD | PMID:16483693 | benzo[a]pyrene | multiple interactions | ISO | RGD:736553 | 6480464 | [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in increased expression of PPT1 mRNA | CTD | PMID:21715664 | benzo[a]pyrene | increases expression | ISO | RGD:736553 | 6480464 | Benzo(a)pyrene results in increased expression of PPT1 mRNA | CTD | PMID:22228805 | bisphenol A | increases expression | ISO | RGD:736552 | 6480464 | bisphenol A results in increased expression of PPT1 mRNA | CTD | PMID:20678512 | choline | multiple interactions | ISO | RGD:736553 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PPT1 mRNA | CTD | PMID:20938992 | cobalt dichloride | decreases expression | ISO | RGD:736552 | 6480464 | cobaltous chloride results in decreased expression of PPT1 mRNA | CTD | PMID:19320972 | cyclosporin A | decreases expression | ISO | RGD:736552 | 6480464 | Cyclosporine results in decreased expression of PPT1 mRNA | CTD | PMID:20106945 | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of PPT1 mRNA | CTD | PMID:21266533 | dibutyl phthalate | decreases expression | ISO | RGD:736553 | 6480464 | Dibutyl Phthalate results in decreased expression of PPT1 mRNA | CTD | PMID:17361019 PMID:21266533 | dibutyl phthalate | decreases expression | ISO | RGD:736553 | 6480464 | Dibutyl Phthalate results in decreased expression of PPT1 mRNA | CTD | PMID:21266533 | folic acid | multiple interactions | ISO | RGD:736553 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PPT1 mRNA | CTD | PMID:20938992 | furan | increases methylation | EXP | | 6480464 | furan results in increased methylation of PPT1 gene | CTD | PMID:22079235 | L-methionine | multiple interactions | ISO | RGD:736553 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PPT1 mRNA | CTD | PMID:20938992 | NAD zwitterion | affects abundance | ISO | RGD:736553 | 6480464 | PPT1 gene mutant form affects the abundance of NAD | CTD | PMID:21224254 | NAD(+) | affects abundance | ISO | RGD:736553 | 6480464 | PPT1 gene mutant form affects the abundance of NAD | CTD | PMID:21224254 | paracetamol | increases expression | ISO | RGD:736552 | 6480464 | Acetaminophen results in increased expression of PPT1 mRNA | CTD | PMID:22230336 | resveratrol | multiple interactions | ISO | RGD:736553 | 6480464 | resveratrol inhibits the reaction [PPT1 gene mutant form results in decreased expression of SYP protein]; more ... | CTD | PMID:21224254 | tamoxifen | affects expression | ISO | RGD:736553 | 6480464 | Tamoxifen affects the expression of PPT1 mRNA | CTD | PMID:17555576 | tetrachloromethane | affects expression | ISO | RGD:736553 | 6480464 | Carbon Tetrachloride affects the expression of PPT1 mRNA | CTD | PMID:17484886 | trans-resveratrol | multiple interactions | ISO | RGD:736553 | 6480464 | resveratrol inhibits the reaction [PPT1 gene mutant form results in decreased expression of SYP protein]; more ... | CTD | PMID:21224254 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Fatty acid elongation |
| Lysosome | |
| Metabolic pathways | |
Disease AnnotationsGene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Fatty acid elongation |
| Lysosome | |
| Metabolic pathways | |
References - curated| 1. |
Camp LA, etal., J Biol Chem 1994 Sep 16;269(37):23212-9. |
| 2. |
GOA data from the GO Consortium |
| 3. |
Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7 |
| 4. |
MGD data from the GO Consortium |
| 5. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 6. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 7. |
RGD automated data pipeline |
| 8. |
RGD automated import pipeline for gene-chemical interactions |
| 9. |
RGD Automated Pipelines |
| 10. |
Suopanki J, etal., Neurobiol Dis 2002 Aug;10(3):247-57. |
| 11. |
Suopanki J, etal., Neurosci Lett. 1999 Apr 9;265(1):53-6. |
| 12. |
Tentative Sequence Data IDs. TIGR Gene Index, Rat Data |
References - uncuratedRGD Disease Portals| Ppt1 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Ppt1 (Rattus norvegicus) |
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| PPT1 (Homo sapiens) |
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| Ppt1 (Mus musculus) |
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Position Markers| Ppt |
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| RH142418 |
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| RH127550 |
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| AA851880 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_022502 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06039768 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01039546 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC126089 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473968 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ213474 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ213911 | (Get FASTA) | Search GEO for Microarray Profiles | |
| L34262 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_022502 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_071947 | ||||||||||||||||||||
| Peptide Label: | precursor | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_071947 | (Get FASTA) |
| GenBank Protein | AAA59358 | (Get FASTA) |
| AAI26090 | (Get FASTA) | |
| EDL80359 | (Get FASTA) | |
| EDL80360 | (Get FASTA) | |
| P45479 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000012616 | UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000017998 | UniProtKB/Swiss-Prot |
| Ensembl Transcript | ENSRNOT00000017998 | UniProtKB/Swiss-Prot |
| Entrez Gene | 29411 | ENTREZGENE |
| Germonline | ENSRNOG00000012616 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 7488 | ENTREZGENE |
| IMAGE_CLONE | IMAGE:8361877 | IMAGE-MGC_LOAD |
| InterPro | Palm_thioest | UniProtKB/Swiss-Prot |
| IPI | IPI00208382 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:29411 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGC_CLONE | MGC:156647 | IMAGE-MGC_LOAD |
| Pfam | Palm_thioest | UniProtKB/Swiss-Prot |
| PRINTS | PPTHIESTRASE | UniProtKB/Swiss-Prot |
| TIGR | TC217109 | |
| UniGene | Rn.1574 | ENTREZGENE |
| UniProt | PPT1_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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| 2006-03-30 | Ppt1 | palmitoyl-protein thioesterase 1 | Ppt | palmitoyl-protein thioesterase | Name updated | 10779 | APPROVED |
| 2002-06-10 | Ppt | palmitoyl-protein thioesterase | Name updated | 1488 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
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| gene_regulation | induced by epileptic seizures | 633701 |
| More on Ppt1 | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 61994 |
| Created: | 2001-04-11 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.