Gene: Map2k4 (mitogen activated protein kinase kinase 4) Rattus norvegicus
Symbol: Map2k4
Name: mitogen activated protein kinase kinase 4
Description: ENCODES a protein that exhibits ATP binding; JUN kinase kinase activity; MAP kinase kinase activity; INVOLVED IN activation of JUN kinase activity; cell growth involved in cardiac muscle cell development; cellular response to sorbitol; PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; Rho/Rac/Cdc42 mediated signaling pathway; ceramide signaling pathway; ASSOCIATED WITH Brain Death; Ischemic Attack, Transient; Retina Reperfusion Injury; FOUND IN axon; cytosol; dendrite cytoplasm; INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; cadmium dichloride
Type: protein-coding
Also known as: dual specificity mitogen-activated protein kinase kinase 4; LOC287398; MAP2K4delta; MKK4; SAPK/ERK kinase 1; Sek1
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01052,196,121 - 52,301,887 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_5.01051,951,707 - 52,054,098 (-)NCBIRnor5.0rn5Rnor5.0
RGSC_v3.41052,009,149 - 52,041,599 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11052,020,408 - 52,055,249 (-)NCBI
Celera1049,553,065 - 49,624,419 (-)NCBI
Cytogenetic Map10q24NCBImapview

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
More on Map2k4
Entrez Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Map Viewer
Vista + UCSC

RGD Object Information
RGD ID: 1307040
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2016-09-02
Status: ACTIVE