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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3371
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pparg
Name: peroxisome proliferator-activated receptor gamma
Acc ID: CHEBI:64212
Term: sulindac sulfone
Definition: A sulfone metabolite of sulindac that inhibits cell growth by inducing apoptosis independently of cyclooxygenase inhibition. It inhibits the development and induces regression of premalignant adenomatous polyps. Lipoxygenase and Cox-2 inhibitor.
Chemical ID: MESH:C025463
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppargincreases expressionISOPPARG (Homo sapiens)6480464CTDsulindac sulfone results in increased expression of PPARG mRNAPMID:11948457
Ppargmultiple interactionsISOPPARG (Homo sapiens)6480464CTD[sulindac sulfone results in increased activity of PPARG protein] promotes the reaction [PPARG protein binds to SAT1 enhancer]; PPARG protein promotes the reaction [sulindac sulfone results in increased expression of SAT1 mRNA]PMID:14506281
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