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Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17alpha-ethynylestradiol | affects expression | EXP | | 6480464 | Ethinyl Estradiol affects the expression of MUC1 mRNA | CTD | PMID:16079270 | 17alpha-ethynylestradiol | increases expression | EXP | | 6480464 | Ethinyl Estradiol results in increased expression of MUC1 mRNA | CTD | PMID:17557909 | 17beta-estradiol | affects expression | ISO | RGD:10927 | 6480464 | Estradiol affects the expression of MUC1 mRNA | CTD | PMID:15598610 | 17beta-estradiol | multiple interactions | ISO | RGD:737252 | 6480464 | [Estradiol binds to ESR2 protein] which results in increased expression of MUC1 mRNA | CTD | PMID:20404318 | 17beta-estradiol | increases expression | ISO | RGD:10927 | 6480464 | Estradiol results in increased expression of MUC1 mRNA | CTD | PMID:15289156 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:10927 | 6480464 | Tetrachlorodibenzodioxin affects the expression of MUC1 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:737252 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of MUC1 protein | CTD | PMID:21410761 | 2-acetamidofluorene | increases expression | EXP | | 6480464 | 2-Acetylaminofluorene results in increased expression of MUC1 mRNA | CTD | PMID:17187413 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | RGD:737252 | 6480464 | [Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of MUC1 mRNA | CTD | PMID:16997883 | 5-aza-2'-deoxycytidine | multiple interactions | ISO | RGD:737252 | 6480464 | decitabine inhibits the reaction [Smoke results in decreased expression of MUC1 mRNA] | CTD | PMID:21095227 | 8-bromo-3',5'-cyclic AMP | multiple interactions | ISO | RGD:737252 | 6480464 | [Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of MUC1 mRNA | CTD | PMID:16997883 | aflatoxin B1 | increases expression | EXP | | 6480464 | Aflatoxin B1 results in increased expression of MUC1 mRNA | CTD | PMID:22484513 | alendronic acid | affects expression | EXP | | 6480464 | Alendronate affects the expression of MUC1 mRNA | CTD | PMID:16079270 | all-trans-retinoic acid | increases expression | ISO | RGD:737252 | 6480464 | Tretinoin results in increased expression of MUC1 protein | CTD | PMID:16473924 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of MUC1 mRNA | CTD | PMID:16483693 | benzo[a]pyrene | decreases expression | ISO | RGD:10927 | 6480464 | Benzo(a)pyrene results in decreased expression of MUC1 mRNA | CTD | PMID:22228805 | bisphenol A | increases expression | ISO | RGD:737252 | 6480464 | bisphenol A results in increased expression of MUC1 mRNA | CTD | PMID:22576693 | cadmium atom | decreases expression | ISO | RGD:10927 | 6480464 | Cadmium results in decreased expression of MUC1 mRNA | CTD | PMID:22666406 | chloroquine | multiple interactions | ISO | RGD:737252 | 6480464 | Chloroquine inhibits the reaction [MUC1 affects the expression of EGFR protein] | CTD | PMID:22457794 | choline | multiple interactions | ISO | RGD:10927 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MUC1 mRNA | CTD | PMID:20938992 | cyclosporin A | decreases expression | EXP | | 6480464 | Cyclosporine results in decreased expression of MUC1 mRNA | CTD | PMID:21865292 | dexamethasone | increases expression | ISO | RGD:737252 | 6480464 | Dexamethasone results in increased expression of MUC1 protein | CTD | PMID:9949172 | dexamethasone | multiple interactions | ISO | RGD:737252 | 6480464 | [Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of MUC1 mRNA | CTD | PMID:16997883 | dexamethasone | multiple interactions | ISO | RGD:737252 | 6480464 | Mifepristone inhibits the reaction [Dexamethasone results in increased expression of MUC1 protein] | CTD | PMID:9949172 | diethylstilbestrol | increases expression | ISO | RGD:10927 | 6480464 | Diethylstilbestrol results in increased expression of MUC1 mRNA | CTD | PMID:15171707 PMID:15289156 | diethylstilbestrol | increases expression | EXP | | 6480464 | Diethylstilbestrol results in increased expression of MUC1 mRNA | CTD | PMID:21658437 | diethylstilbestrol | increases expression | ISO | RGD:10927 | 6480464 | Diethylstilbestrol results in increased expression of MUC1 mRNA | CTD | PMID:15289156 PMID:15171707 | folic acid | affects expression | ISO | RGD:737252 | 6480464 | Folic Acid affects the expression of MUC1 mRNA | CTD | PMID:17320366 | folic acid | multiple interactions | ISO | RGD:10927 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MUC1 mRNA | CTD | PMID:20938992 | genistein | increases expression | ISO | RGD:10927 | 6480464 | Genistein results in increased expression of MUC1 mRNA | CTD | PMID:15289156 | genistein | increases expression | ISO | RGD:737252 | 6480464 | Genistein results in increased expression of MUC1 protein | CTD | PMID:20884965 | genistein | multiple interactions | ISO | RGD:737252 | 6480464 | ESR2 promotes the reaction [Genistein results in increased expression of MUC1 protein] | CTD | PMID:20884965 | hydralazine | multiple interactions | ISO | RGD:737252 | 6480464 | [Hydralazine co-treated with Valproic Acid] results in increased expression of MUC1 mRNA | CTD | PMID:17183730 | indole-3-methanol | decreases expression | ISO | RGD:737252 | 6480464 | indole-3-carbinol results in decreased expression of MUC1 mRNA; more ... | CTD | PMID:15027113 | indole-3-methanol | affects expression | EXP | | 6480464 | indole-3-carbinol affects the expression of MUC1 mRNA | CTD | PMID:21396975 | isotretinoin | decreases expression | ISO | RGD:737252 | 6480464 | Isotretinoin results in decreased expression of MUC1 mRNA | CTD | PMID:20436886 | L-methionine | multiple interactions | ISO | RGD:10927 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MUC1 mRNA | CTD | PMID:20938992 | mifepristone | multiple interactions | ISO | RGD:737252 | 6480464 | Mifepristone inhibits the reaction [Dexamethasone results in increased expression of MUC1 protein] | CTD | PMID:9949172 | N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of MUC1 mRNA | CTD | PMID:20360939 | paracetamol | affects expression | ISO | RGD:10927 | 6480464 | Acetaminophen affects the expression of MUC1 mRNA | CTD | PMID:17562736 | phorbol 13-acetate 12-myristate | multiple interactions | ISO | RGD:737252 | 6480464 | [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of MUC1 mRNA | CTD | PMID:16979875 | pirinixic acid | multiple interactions | ISO | RGD:10927 | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of MUC1 mRNA | CTD | PMID:19710929 | progesterone | affects expression | ISO | RGD:737252 | 6480464 | Progesterone affects the expression of MUC1 protein | CTD | PMID:15971251 | prostaglandin E2 | multiple interactions | ISO | RGD:737252 | 6480464 | [IL4 protein co-treated with CSF2 protein co-treated with TNF protein co-treated with Dinoprostone co-treated with IL1B protein co-treated with IL6 protein] results in increased expression of MUC1 protein | CTD | PMID:18952292 | raloxifene | increases expression | ISO | RGD:737252 | 6480464 | Raloxifene results in increased expression of MUC1 protein | CTD | PMID:16012748 | raloxifene | affects expression | EXP | | 6480464 | Raloxifene affects the expression of MUC1 mRNA | CTD | PMID:16079270 | resveratrol | decreases expression | ISO | RGD:737252 | 6480464 | resveratrol results in decreased expression of MUC1 mRNA | CTD | PMID:15280659 | tamoxifen | affects response to substance | ISO | RGD:737252 | 6480464 | MUC1 protein affects the susceptibility to Tamoxifen | CTD | PMID:19289846 | tert-butyl hydroperoxide | decreases expression | ISO | RGD:737252 | 6480464 | tert-Butylhydroperoxide results in decreased expression of MUC1 mRNA | CTD | PMID:15336504 | trans-resveratrol | decreases expression | ISO | RGD:737252 | 6480464 | resveratrol results in decreased expression of MUC1 mRNA | CTD | PMID:15280659 | valproic acid | multiple interactions | ISO | RGD:737252 | 6480464 | [Hydralazine co-treated with Valproic Acid] results in increased expression of MUC1 mRNA | CTD | PMID:17183730 | vancomycin | decreases expression | ISO | RGD:10927 | 6480464 | Vancomycin results in decreased expression of MUC1 mRNA | CTD | PMID:18930951 | zinc atom | multiple interactions | ISO | RGD:737252 | 6480464 | [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of MUC1 mRNA | CTD | PMID:16979875 | zinc atom | increases expression | ISO | RGD:10927 | 6480464 | Zinc deficiency results in increased expression of MUC1 mRNA | CTD | PMID:20857495 | zinc(0) | multiple interactions | ISO | RGD:737252 | 6480464 | [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of MUC1 mRNA | CTD | PMID:16979875 | zinc(0) | increases expression | ISO | RGD:10927 | 6480464 | Zinc deficiency results in increased expression of MUC1 mRNA | CTD | PMID:20857495 | | 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Gene Ontology AnnotationsDisease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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References - curated| 1. |
Al-Salmi QA, etal., Chest. 2005 Jan;127(1):403-7. |
| 2. |
Aubert S, etal., Cancer Res. 2009 Jul 15;69(14):5707-15. Epub 2009 Jun 23. |
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Briassoulis G, etal., Pediatr Pulmonol. 2006 Aug;41(8):790-5. |
| 4. |
Chang HJ, etal., Pathol Int. 2004 Aug;54(8):576-84. |
| 5. |
Chhieng DC, etal., Cancer. 2003 Dec 25;99(6):365-71. |
| 6. |
de Paiva Haddad LB, etal., J Gastrointest Surg. 2010 Apr;14(4):719-28. Epub 2010 Jan 27. |
| 7. |
DeSouza MM, etal., Biol Reprod 1998 Jun;58(6):1503-7. |
| 8. |
Farina A, etal., J Proteome Res. 2009 Jan;8(1):159-69. |
| 9. |
Guzman K, etal., Am J Physiol 1996 May;270(5 Pt 1):L846-53. |
| 10. |
Hamada H, etal., Intern Med. 1998 Mar;37(3):307-10. |
| 11. |
Hant FN, etal., J Rheumatol. 2009 Apr;36(4):773-80. Epub 2009 Mar 13. |
| 12. |
Ho SB, etal., Cancer Res. 1993 Feb 1;53(3):641-51. |
| 13. |
Imai T, etal., Pediatr Pulmonol. 2002 Feb;33(2):135-41. |
| 14. |
Isaacs J and Murphy CR, Acta Histochem. 2003;105(3):239-43. |
| 15. |
Ishikawa N, etal., Respiration. 2011 Apr 7. |
| 16. |
Jan YY, etal., Ann Surg. 2004 Jul;240(1):89-94. |
| 17. |
Janssen R, etal., Chest. 2003 Dec;124(6):2119-25. |
| 18. |
Janssen R, etal., Sarcoidosis Vasc Diffuse Lung Dis. 2005 Mar;22(1):51-7. |
| 19. |
Kashiwagi H, etal., Oncol Rep. 2001 May-Jun;8(3):485-9. |
| 20. |
Kaufman HL, etal., J Transl Med. 2007 Nov 26;5:60. |
| 21. |
Kawamoto T, etal., Clin Exp Metastasis. 2004;21(4):353-62. |
| 22. |
Kawaoka T, etal., Oncol Rep. 2008 Jul;20(1):155-63. |
| 23. |
Kawasaki Y, etal., J Med Virol. 2009 Dec;81(12):2104-8. |
| 24. |
Kim DH, etal., Neonatology. 2008;93(4):223-9. Epub 2007 Nov 16. |
| 25. |
Kinoshita F, etal., Respir Med. 2004 Nov;98(11):1131-7. |
| 26. |
Kitamura H, etal., Jpn J Cancer Res. 1996 Jun;87(6):631-40. |
| 27. |
Kohlgraf KG, etal., Cancer Res. 2003 Aug 15;63(16):5011-20. |
| 28. |
Kondo H, etal., Anticancer Res. 2008 Jan-Feb;28(1B):379-87. |
| 29. |
Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7 |
| 30. |
Laes JF, etal., Cytogenet Cell Genet 2001;92(1-2):130-3. |
| 31. |
Lederer DJ, etal., Eur Respir J. 2009 Apr;33(4):793-6. |
| 32. |
Lepisto AJ, etal., Cancer Ther. 2008;6(B):955-964. |
| 33. |
MGD data from the GO Consortium |
| 34. |
Mukherjee P, etal., J Immunol. 2009 Jan 1;182(1):216-24. |
| 35. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 36. |
Ogihara T, etal., J Pediatr. 2000 Aug;137(2):280-2. |
| 37. |
Ohshimo S, etal., Sarcoidosis Vasc Diffuse Lung Dis. 2009 Jul;26(1):47-53. |
| 38. |
Park SY, etal., Oncol Rep. 2009 Sep;22(3):649-57. |
| 39. |
RGD automated import pipeline for gene-chemical interactions |
| 40. |
RGD comprehensive gene curation |
| 41. |
Seregni E, etal., Anticancer Res. 1996 Jul-Aug;16(4B):2209-13. |
| 42. |
Shimamoto T, etal., Pancreas. 2010 Mar 30. |
| 43. |
Sirica AE, etal., Hepatology. 2008 Apr;47(4):1178-90. |
| 44. |
Tanaka M, etal., Hematology. 2002 Apr;7(2):105-8. |
| 45. |
Tang W, etal., World J Gastroenterol. 2005 Sep 21;11(35):5450-4. |
| 46. |
Tentative Sequence Data IDs. TIGR Gene Index, Rat Data |
| 47. |
Tinder TL, etal., J Immunol. 2008 Sep 1;181(5):3116-25. |
| 48. |
Tsuboi Y, etal., Int J Pediatr Otorhinolaryngol. 2001 Oct 19;61(1):23-30. |
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Xu H, etal., Hepatogastroenterology. 2008 Nov-Dec;55(88):2000-4. |
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Yamasaki H, etal., Int J Oncol. 2004 Jan;24(1):107-13. |
| 54. |
Yamato T, etal., J Pathol. 1999 May;188(1):30-7. |
References - uncuratedRGD Disease Portals| Muc1 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Muc1 (Rattus norvegicus) |
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| MUC1 (Homo sapiens) |
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| Muc1 (Mus musculus) |
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Position Markers| RH94427 |
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| AU047994 |
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| Muc1 |
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| Muc1 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_012602 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06018797 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01018584 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF007554 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC166505 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_012602 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_036734 | ||||||||||||||||||||
| Peptide Label: | precursor | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_036734 | (Get FASTA) |
| GenBank Protein | AAB62948 | (Get FASTA) |
| AAI66505 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000020539 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000027850 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000027850 | ENTREZGENE, UniProtKB/TrEMBL |
| Entrez Gene | 24571 | ENTREZGENE |
| HomoloGene Group ID | 8416 | ENTREZGENE |
| IMAGE_CLONE | IMAGE:7122817 | IMAGE-MGC_LOAD |
| InterPro | Mucin-1 | UniProtKB/TrEMBL |
| SEA | UniProtKB/TrEMBL | |
| IPI | IPI00373230 | UniProtKB/TrEMBL |
| KEGG Report | rno:24571 | ENTREZGENE, UniProtKB/TrEMBL |
| MGC_CLONE | MGC:188069 | IMAGE-MGC_LOAD |
| PANTHER | Mucin-1 | UniProtKB/TrEMBL |
| Pfam | SEA | UniProtKB/TrEMBL |
| PROSITE | SEA | UniProtKB/TrEMBL |
| SMART | SEA | UniProtKB/TrEMBL |
| TIGR | TC219475 | |
| UniGene | Rn.10779 | ENTREZGENE |
| UniProt | B2GV31_RAT | UniProtKB/TrEMBL |
| O35770_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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| 2008-08-29 | Muc1 | mucin 1, cell surface associated | Muc1 | mucin 1, transmembrane | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2004-09-10 | Muc1 | mucin 1, transmembrane | mucin 1 | Name updated | 10779 | APPROVED | |
| 2002-06-10 | Muc1 | Mucin1 | Symbol and Name status set to approved | 1490 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_expression | expression is decreased at Day 5 of pregnancy in the uterine epithelium | 633409 |
| More on Muc1 | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 3122 |
| Created: | 2000-05-25 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.