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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | RGD:1353304 | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ZNF354A mRNA | CTD | PMID:22079256 | 17alpha-ethynylestradiol | decreases expression | ISO | RGD:10838 | 6480464 | Ethinyl Estradiol results in decreased expression of ZFP354A mRNA | CTD | PMID:17555576 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:10838 | 6480464 | Tetrachlorodibenzodioxin affects the expression of ZFP354A mRNA | CTD | PMID:16962184 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of ZFP354A mRNA | CTD | PMID:20959002 more ... | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of ZFP354A mRNA | CTD | PMID:21215274 PMID:21724226 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of ZFP354A mRNA | CTD | PMID:21215274 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of ZFP354A mRNA | CTD | PMID:22298810 | 3,3',4,4',5-pentachlorobiphenyl | decreases expression | EXP | | 6480464 | 3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of ZFP354A mRNA | CTD | PMID:20959002 | 3H-1,2-dithiole-3-thione | decreases expression | EXP | | 6480464 | 1,2-dithiol-3-thione results in decreased expression of ZFP354A mRNA | CTD | PMID:19162173 | 4,4'-diaminodiphenylmethane | decreases expression | ISO | RGD:10838 | 6480464 | 4,4'-diaminodiphenylmethane results in decreased expression of ZFP354A mRNA | CTD | PMID:18648102 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of ZFP354A mRNA | CTD | PMID:16483693 | benzo[a]pyrene | multiple interactions | ISO | RGD:10838 | 6480464 | [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in decreased expression of ZFP354A mRNA | CTD | PMID:21715664 | benzo[a]pyrene | increases expression | ISO | RGD:10838 | 6480464 | Benzo(a)pyrene results in increased expression of ZFP354A mRNA | CTD | PMID:22228805 | cadmium dichloride | increases methylation | EXP | | 6480464 | Cadmium Chloride results in increased methylation of ZFP354A promoter | CTD | PMID:22457795 | coumestrol | decreases expression | ISO | RGD:1353304 | 6480464 | Coumestrol results in decreased expression of ZNF354A mRNA | CTD | PMID:19167446 | coumestrol | multiple interactions | ISO | RGD:1353304 | 6480464 | [Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of ZNF354A mRNA | CTD | PMID:19167446 | cyclosporin A | increases expression | ISO | RGD:1353304 | 6480464 | Cyclosporine results in increased expression of ZNF354A mRNA | CTD | PMID:20106945 | formaldehyde | decreases expression | ISO | RGD:1353304 | 6480464 | Formaldehyde results in decreased expression of ZNF354A mRNA | CTD | PMID:20655997 | furan | increases methylation | EXP | | 6480464 | furan results in increased methylation of ZFP354A gene | CTD | PMID:22079235 | gamma-hexachlorocyclohexane | increases expression | EXP | | 6480464 | Lindane results in increased expression of ZFP354A mRNA | CTD | PMID:17785943 | genistein | decreases expression | EXP | | 6480464 | Genistein results in decreased expression of ZFP354A mRNA | CTD | PMID:15901920 | hydrogen peroxide | multiple interactions | ISO | RGD:1353304 | 6480464 | [Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ZNF354A protein | CTD | PMID:18951874 | N-nitrosodiethylamine | decreases expression | EXP | | 6480464 | Diethylnitrosamine results in decreased expression of ZFP354A mRNA | CTD | PMID:19638242 | N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ZNF354A mRNA | CTD | PMID:18164116 | paracetamol | affects expression | ISO | RGD:10838 | 6480464 | Acetaminophen affects the expression of ZFP354A mRNA | CTD | PMID:17562736 | perfluorooctanoic acid | increases expression | EXP | | 6480464 | perfluorooctanoic acid results in increased expression of ZFP354A mRNA | CTD | PMID:19162173 | phenobarbital | affects expression | ISO | RGD:10838 | 6480464 | Phenobarbital affects the expression of ZFP354A mRNA | CTD | PMID:19136022 | phenobarbital | affects expression | ISO | RGD:1353304 | 6480464 | Phenobarbital affects the expression of ZNF354A mRNA | CTD | PMID:19159669 | phenobarbital | affects expression | EXP | | 6480464 | Phenobarbital affects the expression of ZFP354A mRNA | CTD | PMID:19162173 | pirinixic acid | multiple interactions | ISO | RGD:1353304 | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ZNF354A mRNA | CTD | PMID:19710929 | pirinixic acid | increases expression | EXP | | 6480464 | pirinixic acid results in increased expression of ZFP354A mRNA | CTD | PMID:19162173 | pirinixic acid | affects expression | ISO | RGD:10838 | 6480464 | pirinixic acid affects the expression of ZFP354A mRNA | CTD | PMID:19136022 | pregnenolone 16alpha-carbonitrile | decreases expression | EXP | | 6480464 | Pregnenolone Carbonitrile results in decreased expression of ZFP354A mRNA | CTD | PMID:19162173 | rosiglitazone | increases expression | EXP | | 6480464 | rosiglitazone results in increased expression of ZFP354A mRNA | CTD | PMID:21515302 | sevoflurane | affects expression | EXP | | 6480464 | sevoflurane affects the expression of ZFP354A mRNA | CTD | PMID:15967596 | sulindac | increases expression | ISO | RGD:1353304 | 6480464 | Sulindac results in increased expression of ZNF354A mRNA | CTD | PMID:11906190 | tamoxifen | affects expression | ISO | RGD:10838 | 6480464 | Tamoxifen affects the expression of ZFP354A mRNA | CTD | PMID:17555576 | theophylline | multiple interactions | ISO | RGD:1353304 | 6480464 | [Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ZNF354A protein | CTD | PMID:18951874 | trimellitic anhydride | decreases expression | ISO | RGD:10838 | 6480464 | trimellitic anhydride results in decreased expression of ZFP354A mRNA | CTD | PMID:19042947 | troglitazone | increases expression | EXP | | 6480464 | troglitazone results in increased expression of ZFP354A mRNA | CTD | PMID:21515302 | valproic acid | affects expression | ISO | RGD:10838 | 6480464 | Valproic Acid affects the expression of ZFP354A mRNA | CTD | PMID:17963808 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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References - curated| 1. |
GOA data from the GO Consortium |
| 2. |
Huang Z, etal., J Biol Chem 1999 Mar 19;274(12):7640-8. |
| 3. |
Przyborski SA, etal., Cancer Res. 1998 Oct 15;58(20):4598-601. |
| 4. |
RGD automated data pipeline |
| 5. |
RGD automated import pipeline for gene-chemical interactions |
| 6. |
Shakib K, etal., Proteomics. 2005 Jul;5(11):2819-38. |
| 7. |
Strausberg RL, etal., Proc Natl Acad Sci U S A 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11. |
| 8. |
Witzgall R, etal., Mol Cell Biol 1993 Mar;13(3):1933-42. |
References - uncurated
RGD Disease Portals| Zfp354a has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Zfp354a (Rattus norvegicus) |
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| ZNF354A (Homo sapiens) |
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| Zfp354a (Mus musculus) |
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Position Markers| RH137320 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_052798 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06063796 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01063802 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC078777 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473948 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M96548 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_052798 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_434685 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_434685 | (Get FASTA) |
| GenBank Protein | AAB07673 | (Get FASTA) |
| AAH78777 | (Get FASTA) | |
| EDM04296 | (Get FASTA) | |
| EDM04298 | (Get FASTA) | |
| Q02975 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000003634 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000049437 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Transcript | ENSRNOT00000045596 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Entrez Gene | 24522 | ENTREZGENE |
| Gene3D-CATH | Znf_C2H2/integrase_DNA-bd | UniProtKB/Swiss-Prot |
| Germonline | ENSRNOG00000003634 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 55921 | ENTREZGENE |
| IMAGE_CLONE | IMAGE:7127868 | IMAGE-MGC_LOAD |
| InterPro | Krueppel-associated_box | UniProtKB/Swiss-Prot |
| Znf_C2H2 | UniProtKB/Swiss-Prot | |
| Znf_C2H2-like | UniProtKB/Swiss-Prot | |
| Znf_C2H2/integrase_DNA-bd | UniProtKB/Swiss-Prot | |
| IPI | IPI00211992 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:24522 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGC_CLONE | MGC:93316 | IMAGE-MGC_LOAD |
| Pfam | KRAB | UniProtKB/Swiss-Prot |
| PROSITE | KRAB | UniProtKB/Swiss-Prot |
| ZINC_FINGER_C2H2_1 | UniProtKB/Swiss-Prot | |
| ZINC_FINGER_C2H2_2 | UniProtKB/Swiss-Prot | |
| SMART | KRAB | UniProtKB/Swiss-Prot |
| ZnF_C2H2 | UniProtKB/Swiss-Prot | |
| Superfamily-SCOP | Krueppel-associated_box | UniProtKB/Swiss-Prot |
| UniGene | Rn.11049 | ENTREZGENE |
| UniProt | Q6AZ27_RAT | UniProtKB/TrEMBL |
| Z354A_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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| 2005-11-17 | Zfp354a | zinc finger protein 354A | Symbol updated | 10779 | APPROVED | ||
| 2002-02-20 | Znf354a | zinc finger protein 354A | Symbol and Name updated to reflect Human and Mouse nomenclature | 1320 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_expression | expressed predominantly in the kidney | 1300202 |
| gene_expression | mRNA accumulates with age in postnatal renal development | 1300202 |
| More on Zfp354a | |
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Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 2967 |
| Created: | 2000-05-25 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




