Zfp354a (zinc finger protein 354A)

Gene: Zfp354a (zinc finger protein 354A) Rattus norvegicus

Analyze

Symbol:

Zfp354a

Name:

zinc finger protein 354A

RGD ID:

2967

Description:

Enables DNA-binding transcription factor activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; nucleolus organization; and response to folic acid. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be active in nucleus. Orthologous to human ZNF354A (zinc finger protein 354A); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Kid1; Kidney 1; kidney, ischemia, and developmentally-regulated protein 1; renal transcription factor Kid-1; TCF-17; Tcf17; transcription factor 17; Znf354a

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ZNF354A (zinc finger protein 354A)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB
Mus musculus (house mouse):	Zfp354a (zinc finger protein 354A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ZNF354A (zinc finger protein 354A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ZNF354A (zinc finger protein 354A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Znf354a (zinc finger protein 354A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ZNF354B (zinc finger protein 354B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ZNF354A (zinc finger protein 354A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	ZNF354B (zinc finger protein 354B)	HGNC	OrthoDB, Treefam
Homo sapiens (human):	ZNF599 (zinc finger protein 599)	HGNC	PhylomeDB
Alliance orthologs ³
Mus musculus (house mouse):	Zfp354a (zinc finger protein 354A)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	ZNF354A (zinc finger protein 354A)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	ZAP1	Alliance	DIOPT (Hieranoid\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	35,897,217 - 35,909,063 (+)	NCBI		GRCr8
mRatBN7.2	10	35,396,242 - 35,408,069 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	35,396,231 - 35,408,068 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	40,090,257 - 40,102,066 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	39,580,564 - 39,592,373 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	35,083,940 - 35,095,749 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	36,586,495 - 36,600,172 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	36,589,181 - 36,600,469 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	36,356,854 - 36,370,682 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	36,654,406 - 36,665,659 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	36,655,454 - 36,666,708 (+)	NCBI
Celera	10	34,753,775 - 34,765,028 (+)	NCBI		Celera
Cytogenetic Map	10	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Ehlers-Danlos syndrome dermatosparaxis type (ISO)

Ehlers-Danlos syndrome spondylodysplastic type 2 (ISO)

genetic disease (ISO)

in situ carcinoma (ISO)

Reperfusion Injury (IEP)

seminoma (ISO)

Sotos syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

1,2-dimethylhydrazine (ISO)

1-naphthyl isothiocyanate (EXP)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP,ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,3,4,7,8-Pentachlorodibenzofuran (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3,4-methylenedioxymethamphetamine (ISO)

3-chloropropane-1,2-diol (EXP)

3H-1,2-dithiole-3-thione (EXP)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (EXP)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

Actein (EXP)

aflatoxin M1 (ISO)

ammonium chloride (EXP)

benzo[a]pyrene (ISO)

beta-naphthoflavone (EXP)

bisphenol A (EXP)

bisphenol F (EXP)

bromobenzene (EXP)

buspirone (EXP)

cadmium dichloride (EXP)

chlorpyrifos (ISO)

cobalt dichloride (EXP)

coumestrol (ISO)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

doxorubicin (ISO)

Enterolactone (ISO)

epoxiconazole (ISO)

erythromycin estolate (EXP)

ethanol (ISO)

ethyl methanesulfonate (ISO)

flavonoids (EXP)

formaldehyde (ISO)

furan (EXP)

gamma-hexachlorocyclohexane (EXP)

genistein (EXP)

geraniol (ISO)

hydrogen peroxide (ISO)

isoflurane (ISO)

levofloxacin (EXP)

mercury dichloride (EXP)

metformin (EXP)

methamphetamine (EXP)

methapyrilene (EXP)

methimazole (EXP)

methotrexate (EXP)

Muraglitazar (EXP)

N-nitrosodiethylamine (EXP)

orphenadrine (EXP)

oxycodone (EXP)

paracetamol (EXP,ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP)

phenformin (EXP)

phenobarbital (EXP,ISO)

pirinixic acid (EXP,ISO)

potassium chromate (ISO)

pregnenolone 16alpha-carbonitrile (EXP)

resveratrol (EXP)

sevoflurane (EXP)

sodium arsenite (ISO)

sulfadimethoxine (EXP)

sulindac (ISO)

tamoxifen (ISO)

Tesaglitazar (EXP)

theophylline (ISO)

thioacetamide (EXP)

trimellitic anhydride (ISO)

triphenyl phosphate (EXP)

triptonide (ISO)

troglitazone (EXP)

urethane (ISO)

valdecoxib (EXP)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

kidney development (IEP)

negative regulation of transcription by RNA polymerase II (IMP)

nucleolus organization (IMP)

regulation of DNA-templated transcription (IEA)

regulation of transcription by RNA polymerase II (IBA)

response to folic acid (IEP)

response to hypoxia (IEP)

Cellular Component

cytosol (ISO)

nucleolus (ISO)

nucleoplasm (ISO)

nucleus (IBA,IEA,ISO)

Molecular Function

DNA-binding transcription factor activity (IMP)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA,IEA)

metal ion binding (IEA)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA,IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Expression of the transcriptional repressor protein Kid-1 leads to the disintegration of the nucleolus.	Huang Z, etal., J Biol Chem 1999 Mar 19;274(12):7640-8.
4.	Differential expression of the zinc finger gene TCF17 in testicular tumors.	Przyborski SA, etal., Cancer Res. 1998 Oct 15;58(20):4598-601.
5.	GOA pipeline	RGD automated data pipeline
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Proteomics profiling of nuclear proteins for kidney fibroblasts suggests hypoxia, meiosis, and cancer may meet in the nucleus.	Shakib K, etal., Proteomics. 2005 Jul;5(11):2819-38.
9.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
10.	Kid-1, a putative renal transcription factor: regulation during ontogeny and in response to ischemia and toxic injury.	Witzgall R, etal., Mol Cell Biol 1993 Mar;13(3):1933-42.

Additional References at PubMed

PMID:8020966	PMID:19519174	PMID:21630459	PMID:23665872

Genomics

Comparative Map Data

Zfp354a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	35,897,217 - 35,909,063 (+)	NCBI		GRCr8
mRatBN7.2	10	35,396,242 - 35,408,069 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	35,396,231 - 35,408,068 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	40,090,257 - 40,102,066 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	39,580,564 - 39,592,373 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	35,083,940 - 35,095,749 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	36,586,495 - 36,600,172 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	36,589,181 - 36,600,469 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	36,356,854 - 36,370,682 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	36,654,406 - 36,665,659 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	36,655,454 - 36,666,708 (+)	NCBI
Celera	10	34,753,775 - 34,765,028 (+)	NCBI		Celera
Cytogenetic Map	10	q22	NCBI

ZNF354A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	178,711,512 - 178,730,659 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	178,711,512 - 178,730,659 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	178,138,513 - 178,157,660 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	178,071,128 - 178,090,309 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	178,071,127 - 178,090,309	NCBI
Celera	5	173,765,092 - 173,784,470 (-)	NCBI		Celera
Cytogenetic Map	5	q35.3	NCBI
HuRef	5	172,864,540 - 172,883,740 (-)	NCBI		HuRef
CHM1_1	5	177,570,885 - 177,590,072 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	5	179,263,543 - 179,282,761 (-)	NCBI		T2T-CHM13v2.0

Zfp354a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	50,950,052 - 50,963,626 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	50,950,084 - 50,963,626 (+)	Ensembl		GRCm39 Ensembl
GRCm38	11	51,059,225 - 51,072,799 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	51,059,257 - 51,072,799 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	50,872,759 - 50,886,301 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	50,902,680 - 50,914,687 (+)	NCBI		MGSCv36	mm8
Celera	11	55,618,339 - 55,632,502 (+)	NCBI		Celera
Cytogenetic Map	11	B1.3	NCBI
cM Map	11	30.97	NCBI

ZNF354A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	173,652,871 - 173,716,286 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	171,792,413 - 171,855,824 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	173,869,993 - 173,931,852 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	181,126,400 - 181,145,294 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	181,126,400 - 181,141,632 (-)	Ensembl	panpan1.1		panPan2

ZNF354A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	11	2,897,998 - 2,918,304 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	11	2,898,234 - 2,917,725 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	11	3,041,879 - 3,062,266 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	11	2,874,551 - 2,894,729 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	11	2,767,184 - 2,894,724 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	11	2,845,270 - 2,865,424 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	11	2,923,862 - 2,944,209 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	11	3,164,893 - 3,185,279 (+)	NCBI		UU_Cfam_GSD_1.0

Znf354a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	113,011,386 - 113,015,649 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936647	15,966 - 17,935 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936647	16,233 - 18,411 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ZNF354B
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	79,579,753 - 79,601,137 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	79,579,737 - 79,602,080 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	81,245,570 - 81,272,296 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ZNF354A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	80,407,134 - 80,425,920 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	23	80,407,085 - 80,423,055 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666075	11,722,320 - 11,741,404 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Variants

Variants in Zfp354a
41 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	357
Count of miRNA genes:	223
Interacting mature miRNAs:	254
Transcripts:	ENSRNOT00000045596
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
634327	Hc4	Hypercalciuria QTL 4	2.4		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	10	1	38328221	Rat
7411611	Foco17	Food consumption QTL 17	18.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	10	1	42315980	Rat
70223	Bp57	Blood pressure QTL 57	5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	1	80676123	Rat
10401803	Kidm50	Kidney mass QTL 50			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	10	418344	45418344	Rat
631554	Bp133	Blood pressure QTL 133		0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	743364	63851208	Rat
2313064	Bmd71	Bone mineral density QTL 71	0.9	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	10	5387014	50387014	Rat
2313066	Bss63	Bone structure and strength QTL 63	1.4	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	10	5387014	50387014	Rat
2313081	Bss64	Bone structure and strength QTL 64	1.3	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	10	5387014	50387014	Rat
2313095	Bss62	Bone structure and strength QTL 62	1.5	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	10	5387014	50387014	Rat
2313104	Bss61	Bone structure and strength QTL 61	0.9	0.0001	tibia area (VT:1000281)	tibia midshaft cross-sectional area (CMO:0001717)	10	5387014	50387014	Rat
2298544	Neuinf9	Neuroinflammation QTL 9	4.6		nervous system integrity trait (VT:0010566)	spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)	10	5801990	62146030	Rat
8662860	Vetf10	Vascular elastic tissue fragility QTL 10			artery integrity trait (VT:0010639)	number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)	10	6154182	73453136	Rat
61427	Cia16	Collagen induced arthritis QTL 16	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	6357896	96121100	Rat
1578761	Stresp21	Stress response QTL 21	3.3		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	10	6375746	51375746	Rat
2303118	Mamtr7	Mammary tumor resistance QTL 7		0.003	mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	10	9658275	104670812	Rat
9590310	Scort19	Serum corticosterone level QTL 19	6.3	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	11474010	56474010	Rat
9590268	Scort13	Serum corticosterone level QTL 13	3.26	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	11474010	56474010	Rat
9589136	Insul27	Insulin level QTL 27	10.46	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	10	11474010	56474010	Rat
2301967	Cm73	Cardiac mass QTL 73	4.55		heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	10	14487011	89062041	Rat
631268	Cia21	Collagen induced arthritis QTL 21	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	14487011	104060283	Rat
2316949	Gluco60	Glucose level QTL 60	3.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	10	14487011	107057807	Rat
1354587	Kidm21	Kidney mass QTL 21	3.3		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	10	15028513	60430477	Rat
631564	Apr3	Acute phase response QTL 3	3.9		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	10	15275955	60275955	Rat
6893350	Bw99	Body weight QTL 99	0.87	0.16	body mass (VT:0001259)	body weight (CMO:0000012)	1	15906665	60906665	Rat
6893352	Bw100	Body weight QTL 100	0.33	0.6	body mass (VT:0001259)	body weight (CMO:0000012)	1	15906665	60906665	Rat
631532	Cm50	Cardiac mass QTL 50	6.6		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	10	17907113	51786432	Rat
1598852	Anxrr19	Anxiety related response QTL 19	5.07		body movement coordination trait (VT:0005424)	number of rearing movements in an experimental apparatus (CMO:0001752)	10	18167841	63167841	Rat
2313055	Bw96	Body weight QTL 96	3.6	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	10	19606483	64606483	Rat
2313087	Bmd80	Bone mineral density QTL 80	3.2	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	10	19606483	64606483	Rat
1554317	Bmd4	Bone mineral density QTL 4	9.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	10	19816042	99406971	Rat
1581497	Esta1	Estrogen-induced thymic atrophy QTL 1			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	10	21329805	61345413	Rat
724556	Pur2	Proteinuria QTL 2	5.5		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	10	22427500	90627625	Rat
631531	Iresp2	Immunoglobin response QTL2	6.3		blood immunoglobulin E amount (VT:0002492)	serum immunoglobulin E level (CMO:0002101)	10	22918268	36400810	Rat
61354	Pia10	Pristane induced arthritis QTL 10		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
631267	Cia20	Collagen induced arthritis QTL 20	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
61325	Aia5	Adjuvant induced arthritis QTL 5		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
70224	Eae3	Experimental allergic encephalomyelitis QTL 3	4.1		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	10	26521957	61345413	Rat
1298069	Bp168	Blood pressure QTL 168	5.5		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	10	26521957	98003205	Rat
631542	Bp82	Blood pressure QTL 82	6.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	26521957	98952741	Rat
2300171	Bmd58	Bone mineral density QTL 58	4.9	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	10	26944628	71944628	Rat
10402859	Bp381	Blood pressure QTL 381		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	27606468	72606468	Rat
2292441	Bp308	Blood pressure QTL 308			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	27606468	72606468	Rat
724527	Bp148	Blood pressure QTL 148		0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	28453136	73453136	Rat
1600371	Mcs21	Mammary carcinoma susceptibility QTL 21	3		mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	10	28875650	52200160	Rat
1331762	Rf40	Renal function QTL 40	3.873		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	10	29299504	64155584	Rat
1331791	Cm31	Cardiac mass QTL 31	3.84606		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	10	29299504	107211142	Rat
631557	Bp136	Blood pressure QTL 136		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	30632053	75632053	Rat
1576311	Pia26	Pristane induced arthritis QTL 26			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	31224026	75632053	Rat
1578779	Tcas10	Tongue tumor susceptibility QTL 10	3.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	10	31297439	76297439	Rat
1576319	Cia29	Collagen induced arthritis QTL 29			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	33973921	78973921	Rat
61332	Eau3	Experimental allergic uveoretinitis QTL 3		0.004	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	10	34490559	45579777	Rat
1354614	Hpcl1	Hepatic cholesterol level QTL 1	3.3		liver cholesterol amount (VT:0010498)	liver cholesterol level (CMO:0001597)	10	35392267	51793994	Rat
1358897	Stresp6	Stress response QTL 6	4.17	0.022	blood norepinephrine amount (VT:0005663)	plasma norepinephrine level (CMO:0001010)	10	35392267	64155584	Rat
61441	Btemp1	Thermal response to stress QTL 1	4		body temperature trait (VT:0005535)	core body temperature (CMO:0001036)	10	35392457	63642539	Rat

Markers in Region

RH137320

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	35,407,774 - 35,407,957 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	36,599,878 - 36,600,060	NCBI	Rnor6.0
Rnor_5.0	10	36,370,388 - 36,370,570	UniSTS	Rnor5.0
RGSC_v3.4	10	36,665,412 - 36,665,594	UniSTS	RGSC3.4
Celera	10	34,764,781 - 34,764,963	UniSTS
RH 3.4 Map	10	385.0	UniSTS
Cytogenetic Map	10	q21	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium			7	5	1	5			7	29	14	10
Low	3	43	50	36	18	36	8	11	67	6	27	1	8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_052798	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008767660	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008767661	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039085190	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC141334	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC078777	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M96548	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000045596 ⟹ ENSRNOP00000049437

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	35,396,278 - 35,407,610 (+)	Ensembl
Rnor_6.0 Ensembl	10	36,589,181 - 36,599,618 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000085203 ⟹ ENSRNOP00000070798

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	35,396,968 - 35,408,068 (+)	Ensembl
Rnor_6.0 Ensembl	10	36,590,325 - 36,600,469 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000097835 ⟹ ENSRNOP00000092943

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	35,396,231 - 35,408,068 (+)	Ensembl

RefSeq Acc Id:

NM_052798 ⟹ NP_434685

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	35,897,263 - 35,909,063 (+)	NCBI
mRatBN7.2	10	35,396,269 - 35,408,069 (+)	NCBI
Rnor_6.0	10	36,588,872 - 36,600,125 (+)	NCBI
Rnor_5.0	10	36,356,854 - 36,370,682 (+)	NCBI
RGSC_v3.4	10	36,654,406 - 36,665,659 (+)	RGD
Celera	10	34,753,775 - 34,765,028 (+)	RGD

Sequence:

show sequence

GAACAGTCTAAGGGTGTTCACTTTGGGGACTCAGTGAGTCCCCCTCTGTTATGGAGTACAGTGT
CTCTTGAATCTTACTTCTGGAAATCCACGGACAAGAAGACTGGTGACCTATCGATTTTGTGATG
CCCACCCCTGGCTCCTGGTTCCCTCTCTAGAGGCAGAAGAGCCAGGCGCAGCTAATGGGACGCT
TTCGGAGATGCTGCGTCTGACAGGTGCGAAGCAACATGTGCAACTCCTTTCTTCTTCCTCCCCT
CAGATCCTCCTCCATCTTCACCCATCTTTAGAGGAAGAGCCTACAGAAAGAAGATGGCTCCTGA
GCAAAGAGAAGGGGCCTCTCAGGTGTCAGTGACATTTGAAGATGTGGCTGTGCTCTTTACTCGG
GACGAGTGGAAGAAGCTGGATCTGTCTCAGAGAAGCCTGTACCGTGAGGTGATGCTGGAGAATT
ACAGCAACCTGGCCTCCATGGCAGGATTCCTGTTTACCAAACCAAAGGTGATCTCCCTGTTGCA
GCAAGGAGAGGATCCCTGGCAGGTGGAGAAAGAGGGCCCCAGATACTTCTCTCTCGGATTGAAG
TGCAGTCATAGAACCACTAAGTCAACTCAAACACAAGACTCTTCATTTCAGGAACTGATTGTAA
GAAAATCTAAAAGAACCTTTGCCTTCGAACCTTTGAACATGAAGTCAGAAAATCTTTTCATACA
TGAAGGCAAATTAGAGGAAAAGTGGGATAAGAATACTTTGACTGTAGAAAGAAGCCATAAAAAC
AATGAATTTAGCCCAAAGTCCCATAGAGAAAAACGGTCCTCAGAATGTAAAAAGCAGATATCTT
ATTTATCTAACCCACCAGGAATCACACCGGATAAACGCTATAAATGTAGCATGTGTGAGAAAAC
CTTCATTAACACCTCATCTCTTCGCAAACATGAGAAAAACCATAGTGGAGAGAAATTATTTAAA
TGTAAAGAATGTTCAAAAGCCTTCAGCCAAAGTTCAGCCCTTATTCAACATCAAATAACTCACA
CTGGAGAGAAGCCTTACGTATGTAAAGAATGTGGGAAGGCCTTCACTCTCAGTACGTCCCTGTA
TAAACATCTCAGAACCCACACTGTGGAGAAATCCTACAGATGTAAGGAATGTGGTAAATCCTTT
GGCCAAAGGTCAGGTCTTTTTATACACCAGAAGATCCATGCCCGAGAAAACCCTCATAGATATA
ACCCAGGAAGGAAGGCATCCGCTTCCCTCTCTGGATGCCAGAGAGCTCATTCCAGGAAGAAGAC
CTACTTGTGTAATGAATGTGGCAACACCTTCAAGTCTAGCTCCTCCCTCCGTTACCATCAGAGA
ATCCACACCGGAGAGAAACCTTTCAGATGTAGCGAATGCGGCAGAGCCTTCAGTCAGAGCGCAT
CACTTATTCAGCACGAAAGAATCCACACGGGAGAAAAGCCCTACAGGTGTGGCGAGTGTGGGAA
AGGCTTCACTTCTATCTCAAGACTCAATAGACACCGGATAATTCATACAGGAGAGAAATTGTAT
AATTGCAATGAGTGTGGCAAAGCCTTAAGTTCCCACTCAACTCTTATTATTCACGAACGAATCC
ACACTGGAGAGAAACCGTGTAAATGTAAAGTTTGTGGGAAAGCCTTCAGACAGAGTTCAGCTCT
GATCCAACATCAGAGAATGCACACTGGGGAAAGACCCTATAAATGTAATGAGTGCGGGAAAACA
TTCAGGTGTAACTCATCCCTAAGTAACCACCAGCGAATCCACACTGGAGAGAAACCTTATCAAT
GTATAGAATGTGGGATGTCGTTTGGACAAAGTTCTGCTCTTATTCAGCACCGAAGGATTCACAC
GGGAGAGAAACCGTTTAAATGTAACACATGCGGAAAGACCTTTAGGCAGAGCTCCTCACGTATA
GCACATCAGCGAATTCATACTGGGGAGAAACCCTACGAATGTAACACGTGTGGGAAACTTTTCA
ACTATAGGTCATCCCTTACCAATCATTATAAAATCCATGTGGATGAGGACCCTTAAAAAGTAAA
TTTGCATGTAAAAAAGCCTTAAACCAAAGCTCTTCAGAGAATGGGCTTGAGAGCTGTAATAAAC
ATACTATGGCGTCCCTGTAGTCATTTAGTTACTGTCAACTAAATTCCATGGATAAATCCTGTGT
AACAGGTAGGAGTGAAATATTCATGCCTGTCCAACACTTTAAAAAAATTGCTTGAAATCCGGTG
GTTATGTGTAGTCCTGGCTACCGGGGACCCTGAGGATTGCTTGACTCCACAAGTTTGAAGAGCA
AATGTTATGGAGCTTTCCATCTCAGAAGATTAGTGACCTGAAATGAAGAATTCACAGCTGAAGG
CCTTGACTTCAGGTATTTGGAAAATGGTGCTTTTCTCTCTGCAACAGTGTGTGCTAGATACAAT
TGTAATCATAGGCATCTAAGTGAACAGAGGAGTGGGATGGACTTAGCAAAACACAAAACTCTAC
TGTTGTGATACTTTTATACTATTTTAATAATATCCAAAAGGGATCAACACAAATCAAAAAAAAA
A

hide sequence

RefSeq Acc Id:

XM_008767660 ⟹ XP_008765882

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	35,897,217 - 35,909,059 (+)	NCBI
mRatBN7.2	10	35,396,242 - 35,408,065 (+)	NCBI
Rnor_6.0	10	36,587,889 - 36,600,172 (+)	NCBI

Sequence:

show sequence

GAAAAGAAGTTTAAAGACATTTATTGTTTGTGTATATGAAATGAGTGTGTATGAGCATGGAATG
TATGCACTGACCTGAGATGCCAGAAGGGGATGTTGGAACCCAGGCGCTGCAGTTACAGGCCATT
GTGAGCAACCTGATATGGGTAGTGGGGATTGAACCTAAGTCCTCAGCAAGAACAGTAAGGATTC
TTAACCGCTGAGCACTTCTTCAGTCCTACTAATACCTCATAATAAAGCTCTTCTGAAGGGCACT
TCGTGTCAGCTTCCTTTCCACGAACCTGCGACATCGTTTATTATTTACCTACCAAGCAGGTGTT
CAGTTACTAGTGTCCACTCTCAGCTTCCAAGCAATCTGTGCATAAGAAGAGTCCCAGACAAACC
GAAGAACTTCAAATCCCAGAATCCCTGGGTCTCAGAGTGGACTACATTTCCCAGAGGCCTCCTC
AGTCATTACCCTCGAACCTCAAGTTCTGAGCCCCCGTGAGCCTTCGCGGATCATAGGGAGTCTG
TGGCACCGCTAGAGACTCGGGGCCAAGGTCCTAAGACAGACTTCTCACAGGCGCGGAGGTTCAG
AGCGTATGTGAGGTGCGGCGGGAGCCGGGGAAAAGATCCTCCTCCATCTTCACCCATCTTTAGA
GGAAGAGCCTACAGAAAGAAGATGGCTCCTGAGCAAAGAGAAGGGGCCTCTCAGGTGTCAGTGA
CATTTGAAGATGTGGCTGTGCTCTTTACTCGGGACGAGTGGAAGAAGCTGGATCTGTCTCAGAG
AAGCCTGTACCGTGAGGTGATGCTGGAGAATTACAGCAACCTGGCCTCCATGGGATTCCTGTTT
ACCAAACCAAAGGTGATCTCCCTGTTGCAGCAAGGAGAGGATCCCTGGCAGGTGGAGAAAGAGG
GCCCCAGATACTTCTCTCTCGGATTGAAGTGCAGTCATAGAACCACTAAGTCAACTCAAACACA
AGACTCTTCATTTCAGGAACTGATTGTAAGAAAATCTAAAAGAACCTTTGCCTTCGAACCTTTG
AACATGAAGTCAGAAAATCTTTTCATACATGAAGGCAAATTAGAGGAAAAGTGGGATAAGAATA
CTTTGACTGTAGAAAGAAGCCATAAAAACAATGAATTTAGCCCAAAGTCCCATAGAGAAAAACG
GTCCTCAGAATGTAAAAAGCAGATATCTTATTTATCTAACCCACCAGGAATCACACCGGATAAA
CGCTATAAATGTAGCATGTGTGAGAAAACCTTCATTAACACCTCATCTCTTCGCAAACATGAGA
AAAACCATAGTGGAGAGAAATTATTTAAATGTAAAGAATGTTCAAAAGCCTTCAGCCAAAGTTC
AGCCCTTATTCAACATCAAATAACTCACACTGGAGAGAAGCCTTACGTATGTAAAGAATGTGGG
AAGGCCTTCACTCTCAGTACGTCCCTGTATAAACATCTCAGAACCCACACTGTGGAGAAATCCT
ACAGATGTAAGGAATGTGGTAAATCCTTTGGCCAAAGGTCAGGTCTTTTTATACACCAGAAGAT
CCATGCCCGAGAAAACCCTCATAGATATAACCCAGGAAGGAAGGCATCCGCTTCCCTCTCTGGA
TGCCAGAGAGCTCATTCCAGGAAGAAGACCTACTTGTGTAATGAATGTGGCAACACCTTCAAGT
CTAGCTCCTCCCTCCGTTACCATCAGAGAATCCACACCGGAGAGAAACCTTTCAGATGTAGCGA
ATGCGGCAGAGCCTTCAGTCAGAGCGCATCACTTATTCAGCACGAAAGAATCCACACGGGAGAA
AAGCCCTACAGGTGTGGCGAGTGTGGGAAAGGCTTCACTTCTATCTCAAGACTCAATAGACACC
GGATAATTCATACAGGAGAGAAATTGTATAATTGCAATGAGTGTGGCAAAGCCTTAAGTTCCCA
CTCAACTCTTATTATTCACGAACGAATCCACACTGGAGAGAAACCGTGTAAATGTAAAGTTTGT
GGGAAAGCCTTCAGACAGAGTTCAGCTCTGATCCAACATCAGAGAATGCACACTGGGGAAAGAC
CCTATAAATGTAATGAGTGCGGGAAAACATTCAGGTGTAACTCATCCCTAAGTAACCACCAGCG
AATCCACACTGGAGAGAAACCTTATCAATGTATAGAATGTGGGATGTCGTTTGGACAAAGTTCT
GCTCTTATTCAGCACCGAAGGATTCACACGGGAGAGAAACCGTTTAAATGTAACACATGCGGAA
AGACCTTTAGGCAGAGCTCCTCACGTATAGCACATCAGCGAATTCATACTGGGGAGAAACCCTA
CGAATGTAACACGTGTGGGAAACTTTTCAACTATAGGTCATCCCTTACCAATCATTATAAAATC
CATGTGGATGAGGACCCTTAAAAAGTAAATTTGCATGTAAAAAAGCCTTAAACCAAAGCTCTTC
AGAGAATGGGCTTGAGAGCTGTAATAAACATACTATGGCGTCCCTGTAGTCATTTAGTTACTGT
CAACTAAATTCCATGGATAAATCCTGTGTAACAGGTAGGAGTGAAATATTCATGCCTGTCCAAC
ACTTTAAAAAAATTGCTTGAAATCCGGTGGTTATGTGTAGTCCTGGCTACCGGGGACCCTGAGG
ATTGCTTGACTCCACAAGTTTGAAGAGCAAATGTTATGGAGCTTTCCATCTCAGAAGATTAGTG
ACCTGAAATGAAGAATTCACAGCTGAAGGCCTTGACTTCAGGTATTTGGAAAATGGTGCTTTTC
TCTCTGCAACAGTGTGTGCTAGATACAATTGTAATCATAGGCATCTAAGTGAACAGAGGAGTGG
GATGGACTTAGCAAAACACAAAACTCTACTGTTGTGATACTTTTATACTATTTTAATAATATCC
AAAAGGGATCAACACATTTAAAAAAAAAAGCCGAAATAAAAGATTTAAATGAACTGTAATCTA

hide sequence

RefSeq Acc Id:

XM_039085190 ⟹ XP_038941118

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	35,897,217 - 35,909,059 (+)	NCBI
mRatBN7.2	10	35,396,242 - 35,408,065 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_434685	(Get FASTA)	NCBI Sequence Viewer
	XP_008765882	(Get FASTA)	NCBI Sequence Viewer
	XP_038941118	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB07673	(Get FASTA)	NCBI Sequence Viewer
	AAH78777	(Get FASTA)	NCBI Sequence Viewer
	EDM04296	(Get FASTA)	NCBI Sequence Viewer
	EDM04298	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000049437
	ENSRNOP00000049437.4
	ENSRNOP00000070798.2
	ENSRNOP00000092943
	ENSRNOP00000092943.1
	ENSRNOP00055006183
	ENSRNOP00060025424
	ENSRNOP00065005379
GenBank Protein	Q02975	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_434685 ⟸ NM_052798

- UniProtKB:

Q02975 (UniProtKB/Swiss-Prot), A6HE43 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAPEQREGASQVSVTFEDVAVLFTRDEWKKLDLSQRSLYREVMLENYSNLASMAGFLFTKPKVI
SLLQQGEDPWQVEKEGPRYFSLGLKCSHRTTKSTQTQDSSFQELIVRKSKRTFAFEPLNMKSEN
LFIHEGKLEEKWDKNTLTVERSHKNNEFSPKSHREKRSSECKKQISYLSNPPGITPDKRYKCSM
CEKTFINTSSLRKHEKNHSGEKLFKCKECSKAFSQSSALIQHQITHTGEKPYVCKECGKAFTLS
TSLYKHLRTHTVEKSYRCKECGKSFGQRSGLFIHQKIHARENPHRYNPGRKASASLSGCQRAHS
RKKTYLCNECGNTFKSSSSLRYHQRIHTGEKPFRCSECGRAFSQSASLIQHERIHTGEKPYRCG
ECGKGFTSISRLNRHRIIHTGEKLYNCNECGKALSSHSTLIIHERIHTGEKPCKCKVCGKAFRQ
SSALIQHQRMHTGERPYKCNECGKTFRCNSSLSNHQRIHTGEKPYQCIECGMSFGQSSALIQHR
RIHTGEKPFKCNTCGKTFRQSSSRIAHQRIHTGEKPYECNTCGKLFNYRSSLTNHYKIHVDEDP

hide sequence

RefSeq Acc Id:	XP_008765882 ⟸ XM_008767660
- Peptide Label:	isoform X1
- UniProtKB:	Q6AZ27 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAPEQREGASQVSVTFEDVAVLFTRDEWKKLDLSQRSLYREVMLENYSNLASMGFLFTKPKVIS LLQQGEDPWQVEKEGPRYFSLGLKCSHRTTKSTQTQDSSFQELIVRKSKRTFAFEPLNMKSENL FIHEGKLEEKWDKNTLTVERSHKNNEFSPKSHREKRSSECKKQISYLSNPPGITPDKRYKCSMC EKTFINTSSLRKHEKNHSGEKLFKCKECSKAFSQSSALIQHQITHTGEKPYVCKECGKAFTLST SLYKHLRTHTVEKSYRCKECGKSFGQRSGLFIHQKIHARENPHRYNPGRKASASLSGCQRAHSR KKTYLCNECGNTFKSSSSLRYHQRIHTGEKPFRCSECGRAFSQSASLIQHERIHTGEKPYRCGE CGKGFTSISRLNRHRIIHTGEKLYNCNECGKALSSHSTLIIHERIHTGEKPCKCKVCGKAFRQS SALIQHQRMHTGERPYKCNECGKTFRCNSSLSNHQRIHTGEKPYQCIECGMSFGQSSALIQHRR IHTGEKPFKCNTCGKTFRQSSSRIAHQRIHTGEKPYECNTCGKLFNYRSSLTNHYKIHVDEDP hide sequence

RefSeq Acc Id:

ENSRNOP00000049437 ⟸ ENSRNOT00000045596

RefSeq Acc Id:

ENSRNOP00000070798 ⟸ ENSRNOT00000085203

RefSeq Acc Id:	XP_038941118 ⟸ XM_039085190
- Peptide Label:	isoform X2
- UniProtKB:	A0A8L2QNR3 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSRNOP00000092943 ⟸ ENSRNOT00000097835

Protein Domains

C2H2-type KRAB

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q02975-F1-model_v2	AlphaFold	Q02975	1-576	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2967	AgrOrtholog
BioCyc Gene	G2FUF-25210	BioCyc
Ensembl Genes	ENSRNOG00000003634	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSRNOG00055005114	UniProtKB/Swiss-Prot
	ENSRNOG00060018223	UniProtKB/Swiss-Prot
	ENSRNOG00065005260	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000045596.5	UniProtKB/TrEMBL
	ENSRNOT00000085203.2	UniProtKB/TrEMBL
	ENSRNOT00000097835.1	UniProtKB/TrEMBL
	ENSRNOT00055008209	UniProtKB/Swiss-Prot
	ENSRNOT00060031333	UniProtKB/Swiss-Prot
	ENSRNOT00065007748	UniProtKB/Swiss-Prot
Gene3D-CATH	6.10.140.140	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Classic Zinc Finger	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7127868	IMAGE-MGC_LOAD
InterPro	KRAB	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	KRAB_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Znf_C2H2_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Znf_C2H2_type	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:24522	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:93316	IMAGE-MGC_LOAD
NCBI Gene	24522	ENTREZGENE
PANTHER	GENE 10130-RELATED	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	IP01015P-RELATED	UniProtKB/TrEMBL
	KRAB DOMAIN C2H2 ZINC FINGER	UniProtKB/TrEMBL
	KRAB DOMAIN-CONTAINING PROTEIN	UniProtKB/TrEMBL
	REDUCED EXPRESSION 2-RELATED	UniProtKB/TrEMBL
	ZINC FINGER PROTEIN 200	UniProtKB/TrEMBL
	ZINC FINGER PROTEIN 354B	UniProtKB/TrEMBL
	ZNF44 PROTEIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	KRAB	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	zf-C2H2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Zfp354a	PhenoGen
PROSITE	KRAB	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ZINC_FINGER_C2H2_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ZINC_FINGER_C2H2_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000003634	RatGTEx
	ENSRNOG00055005114	RatGTEx
	ENSRNOG00060018223	RatGTEx
	ENSRNOG00065005260	RatGTEx
SMART	KRAB	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ZnF_C2H2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF109640	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF57667	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0G2JYU9_RAT	UniProtKB/TrEMBL
	A0A8I6AIY2_RAT	UniProtKB/TrEMBL
	A0A8L2QNR3	ENTREZGENE, UniProtKB/TrEMBL
	A6HE43	ENTREZGENE, UniProtKB/TrEMBL
	Q02975	ENTREZGENE
	Q6AZ27	ENTREZGENE, UniProtKB/TrEMBL
	Z354A_RAT	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-11-17	Zfp354a	zinc finger protein 354A			Symbol updated	1299863	APPROVED
2002-02-20	Znf354a	zinc finger protein 354A			Symbol and Name updated to reflect Human and Mouse nomenclature	70282	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed predominantly in the kidney	1300202
gene_expression	mRNA accumulates with age in postnatal renal development	1300202

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar