Rassf6 (Ras association domain family member 6) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Rassf6 (Ras association domain family member 6) Rattus norvegicus
Analyze
Symbol: Rassf6
Name: Ras association domain family member 6
RGD ID: 1566082
Description: Predicted to be involved in regulation of apoptotic process and signal transduction. Predicted to act upstream of or within positive regulation of apoptotic process. Orthologous to human RASSF6 (Ras association domain family member 6); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC114410; Ras association (RalGDS/AF-6) domain family member 6; ras association domain-containing protein 6; similar to Ras association (RalGDS/AF-6) domain family 6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81417,717,505 - 17,757,507 (+)NCBIGRCr8
mRatBN7.21417,433,328 - 17,473,565 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1417,442,789 - 17,473,330 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1417,433,546 - 17,473,289 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01418,752,468 - 18,792,218 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01417,444,891 - 17,484,198 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01418,983,852 - 19,023,921 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1418,983,853 - 19,025,971 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01418,892,843 - 18,932,798 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41418,947,511 - 18,987,703 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1416,808,441 - 16,848,145 (+)NCBICelera
Cytogenetic Map14p22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:15489334   PMID:17404571   PMID:24003224  


Genomics

Comparative Map Data
Rassf6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81417,717,505 - 17,757,507 (+)NCBIGRCr8
mRatBN7.21417,433,328 - 17,473,565 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1417,442,789 - 17,473,330 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1417,433,546 - 17,473,289 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01418,752,468 - 18,792,218 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01417,444,891 - 17,484,198 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01418,983,852 - 19,023,921 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1418,983,853 - 19,025,971 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01418,892,843 - 18,932,798 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41418,947,511 - 18,987,703 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1416,808,441 - 16,848,145 (+)NCBICelera
Cytogenetic Map14p22NCBI
RASSF6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38473,571,550 - 73,620,631 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl473,571,550 - 73,620,631 (-)EnsemblGRCh38hg38GRCh38
GRCh37474,437,267 - 74,486,348 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36474,657,726 - 74,705,204 (-)NCBINCBI36Build 36hg18NCBI36
Celera471,798,579 - 71,846,099 (-)NCBICelera
Cytogenetic Map4q13.3NCBI
HuRef470,248,608 - 70,297,731 (-)NCBIHuRef
CHM1_1474,473,102 - 74,522,188 (-)NCBICHM1_1
T2T-CHM13v2.0476,915,192 - 76,964,307 (-)NCBIT2T-CHM13v2.0
Rassf6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39590,750,933 - 90,788,594 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl590,750,935 - 90,788,516 (-)EnsemblGRCm39 Ensembl
GRCm38590,603,076 - 90,640,734 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl590,603,076 - 90,640,657 (-)EnsemblGRCm38mm10GRCm38
MGSCv37591,032,102 - 91,069,513 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36591,678,286 - 91,715,667 (-)NCBIMGSCv36mm8
Celera588,754,754 - 88,792,170 (-)NCBICelera
Cytogenetic Map5E1NCBI
cM Map544.78NCBI
Rassf6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495565749,115 - 59,237 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495565749,115 - 59,237 (-)NCBIChiLan1.0ChiLan1.0
RASSF6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2356,443,998 - 56,492,909 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1456,633,021 - 56,681,918 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0450,575,973 - 50,624,901 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1456,408,103 - 56,457,055 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl456,408,042 - 56,457,055 (+)Ensemblpanpan1.1panPan2
RASSF6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11362,299,717 - 62,344,698 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1362,300,876 - 62,345,372 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1361,969,307 - 62,014,186 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01363,109,864 - 63,154,572 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1363,111,015 - 63,154,670 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11362,720,894 - 62,765,418 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01362,210,231 - 62,255,168 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01363,350,110 - 63,395,236 (-)NCBIUU_Cfam_GSD_1.0
Rassf6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528513,414,677 - 13,456,123 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365981,875,618 - 1,905,202 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365981,866,732 - 1,907,949 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RASSF6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl869,771,934 - 69,831,364 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1869,773,526 - 69,832,158 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2873,873,634 - 73,931,317 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RASSF6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1722,036,965 - 22,086,414 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl722,040,648 - 22,085,148 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666084710,796 - 759,242 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rassf6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473533,872,745 - 33,899,516 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473533,850,506 - 33,900,227 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rassf6
290 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:85
Count of miRNA genes:74
Interacting mature miRNAs:80
Transcripts:ENSRNOT00000003836
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300159Bmd61Bone mineral density QTL 615.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
2300183Bmd60Bone mineral density QTL 605.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
619619Rf4Renal disease susceptibility QTL 44.10.002urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)14381307418274691Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)14381307418274691Rat
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14381307421217635Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14381307424531477Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14381307430767156Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14826709053267090Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14826709053267090Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14908897839057237Rat
2302277Gluco38Glucose level QTL 385.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062228035204Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
631212Bw5Body weight QTL55.43retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)141103081230320092Rat
1300140Srn3Serum renin concentration QTL 33.19blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)141487516830883947Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 11 11 11 16
Low 1 32 46 30 19 30 8 10 68 19 38 11 8
Below cutoff 11 1 6 2

Sequence


RefSeq Acc Id: ENSRNOT00000003836   ⟹   ENSRNOP00000003836
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1417,442,789 - 17,473,330 (+)Ensembl
Rnor_6.0 Ensembl1418,983,853 - 19,025,971 (+)Ensembl
RefSeq Acc Id: NM_001025671   ⟹   NP_001020842
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81417,717,767 - 17,757,507 (+)NCBI
mRatBN7.21417,433,590 - 17,473,333 (+)NCBI
Rnor_6.01418,984,096 - 19,023,706 (+)NCBI
Rnor_5.01418,892,843 - 18,932,798 (+)NCBI
RGSC_v3.41418,947,511 - 18,987,703 (+)RGD
Celera1416,808,441 - 16,848,145 (+)RGD
Sequence:
RefSeq Acc Id: XM_006250745   ⟹   XP_006250807
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81417,717,505 - 17,757,507 (+)NCBI
mRatBN7.21417,433,328 - 17,473,326 (+)NCBI
Rnor_6.01418,983,853 - 19,023,921 (+)NCBI
Rnor_5.01418,892,843 - 18,932,798 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006250747   ⟹   XP_006250809
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81417,717,517 - 17,757,507 (+)NCBI
mRatBN7.21417,433,340 - 17,473,326 (+)NCBI
Rnor_6.01418,983,852 - 19,023,921 (+)NCBI
Rnor_5.01418,892,843 - 18,932,798 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008770036   ⟹   XP_008768258
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81417,720,572 - 17,757,507 (+)NCBI
mRatBN7.21417,442,116 - 17,473,565 (+)NCBI
Rnor_6.01418,992,583 - 19,023,921 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039091869   ⟹   XP_038947797
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81417,746,515 - 17,757,507 (+)NCBI
mRatBN7.21417,462,343 - 17,473,326 (+)NCBI
RefSeq Acc Id: XM_039091870   ⟹   XP_038947798
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81417,720,527 - 17,751,815 (+)NCBI
mRatBN7.21417,442,113 - 17,467,641 (+)NCBI
RefSeq Acc Id: NP_001020842   ⟸   NM_001025671
- UniProtKB: Q4QR82 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006250807   ⟸   XM_006250745
- Peptide Label: isoform X2
- UniProtKB: Q4QR82 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006250809   ⟸   XM_006250747
- Peptide Label: isoform X2
- UniProtKB: Q4QR82 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008768258   ⟸   XM_008770036
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000003836   ⟸   ENSRNOT00000003836
RefSeq Acc Id: XP_038947798   ⟸   XM_039091870
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038947797   ⟸   XM_039091869
- Peptide Label: isoform X4
Protein Domains
Ras-associating   SARAH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4QR82-F1-model_v2 AlphaFold Q4QR82 1-341 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699231
Promoter ID:EPDNEW_R9755
Type:initiation region
Name:Rassf6_1
Description:Ras association domain family member 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01418,983,925 - 18,983,985EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1566082 AgrOrtholog
BioCyc Gene G2FUF-16193 BioCyc
Ensembl Genes ENSRNOG00000002866 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055006140 UniProtKB/Swiss-Prot
  ENSRNOG00060018728 UniProtKB/Swiss-Prot
  ENSRNOG00065017578 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000003836 ENTREZGENE
  ENSRNOT00000003836.7 UniProtKB/Swiss-Prot
  ENSRNOT00055009954 UniProtKB/Swiss-Prot
  ENSRNOT00060032267 UniProtKB/Swiss-Prot
  ENSRNOT00065029397 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7444629 IMAGE-MGC_LOAD
InterPro C-RASSF UniProtKB/Swiss-Prot
  RA_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RASSF1-6 UniProtKB/TrEMBL
  SARAH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SARAH_RASSF6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:305251 UniProtKB/Swiss-Prot
MGC_CLONE MGC:114410 IMAGE-MGC_LOAD
NCBI Gene 305251 ENTREZGENE
PANTHER PTHR22738 UniProtKB/Swiss-Prot
  PTHR22738:SF3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RASSF UniProtKB/TrEMBL
Pfam Nore1-SARAH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00788 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rassf6 PhenoGen
PROSITE PS50200 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SARAH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002866 RatGTEx
  ENSRNOG00055006140 RatGTEx
  ENSRNOG00060018728 RatGTEx
  ENSRNOG00065017578 RatGTEx
SMART SM00314 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54236 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6KKE8_RAT UniProtKB/TrEMBL
  Q4QR82 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-03 Rassf6  Ras association domain family member 6  Rassf6  Ras association (RalGDS/AF-6) domain family member 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-06-27     Rassf6  Ras association (RalGDS/AF-6) domain family member 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Rassf6  Ras association (RalGDS/AF-6) domain family member 6  MGC114410  similar to Ras association (RalGDS/AF-6) domain family 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 MGC114410  similar to Ras association (RalGDS/AF-6) domain family 6      Symbol and Name status set to provisional 70820 PROVISIONAL