Tlr2 (toll-like receptor 2) - Rat Genome Database

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Gene: Tlr2 (toll-like receptor 2) Rattus norvegicus
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Symbol: Tlr2
Name: toll-like receptor 2
RGD ID: 735138
Description: Enables lipopeptide binding activity. Involved in several processes, including central nervous system myelin formation; positive regulation of interleukin-10 production; and response to molecule of bacterial origin. Located in cell body; cell projection; and cell surface. Used to study carotid stenosis; ileitis; keratitis; lung disease (multiple); and renal fibrosis. Biomarker of acute necrotizing pancreatitis; kidney failure; lung disease; pancreatitis; and perinatal necrotizing enterocolitis. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); dermatitis (multiple); gastrointestinal system cancer (multiple); lung disease (multiple); and rhinitis (multiple). Orthologous to human TLR2 (toll like receptor 2); PARTICIPATES IN Toll-like receptor signaling pathway; Chagas disease pathway; Entamoebiasis pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrobenzenesulfonic acid.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: toll-like receptor 2 variant 1; toll-like receptor 2 variant 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Iddm54
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82171,499,189 - 171,504,831 (-)NCBIGRCr8
mRatBN7.22169,200,620 - 169,206,819 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2169,197,419 - 169,206,630 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2176,379,970 - 176,385,353 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02174,399,903 - 174,405,286 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02169,001,363 - 169,006,752 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02182,840,171 - 182,846,061 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2182,840,727 - 182,846,061 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02202,252,701 - 202,258,962 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42175,607,990 - 175,613,992 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12175,558,096 - 175,564,098 (-)NCBI
Celera2163,202,040 - 163,207,399 (-)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal obesity-metabolic syndrome 1  (ISO)
acne  (ISO)
acute kidney failure  (ISO)
acute necrotizing pancreatitis  (IEP)
Acute Tubulointerstitial Nephritis  (ISO)
allergic conjunctivitis  (ISO)
allergic rhinitis  (ISO)
alveolar echinococcosis  (ISO)
anogenital venereal wart  (ISO)
anterior uveitis  (ISO)
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis  (ISO)
aspergillosis  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
atopic dermatitis  (ISO)
atrial fibrillation  (ISO)
Bacterial Eye Infections  (ISO)
Bacterial Keratitis  (ISO)
bacterial pneumonia  (IDA,ISO)
Behcet's disease  (ISO)
Brain Abscess  (ISO)
Brain Hypoxia-Ischemia  (ISO)
Brain Injuries  (IEP,ISO)
breast cancer  (ISO)
cardiomyopathy  (ISO)
Cardiotoxicity  (ISO)
carotid artery thrombosis  (ISO)
carotid stenosis  (IDA)
cholangitis  (ISO)
cholestasis  (ISO)
cholesteatoma  (ISO)
cholesteatoma of middle ear  (ISO)
Choroidal Neovascularization  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Pain  (ISO)
Chronic Periodontitis  (ISO)
clonorchiasis  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
congestive heart failure  (ISO)
Cough  (ISO)
cutaneous leishmaniasis  (ISO)
cystic echinococcosis  (ISO)
dermatomyositis  (ISO)
Diabetic Nephropathies  (ISO)
diffuse scleroderma  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
dry eye syndrome  (ISO)
Dyslipidemias  (IGI)
end stage renal disease  (ISO)
endophthalmitis  (ISO)
Endotoxemia  (IDA)
Eosinophilia  (ISO)
Escherichia Coli Meningitis  (ISO)
essential hypertension  (ISO)
eumycotic mycetoma  (ISO)
Experimental Arthritis  (IEP,ISO)
Experimental Autoimmune Encephalomyelitis  (IEP)
Experimental Autoimmune Neuritis  (IEP)
Experimental Diabetes Mellitus  (IEP,ISO)
Experimental Liver Cirrhosis  (IDA,ISO)
eye disease  (ISO)
Fever  (ISO)
Fungal Eye Infections  (IEP)
gastroesophageal reflux disease  (ISO)
genetic disease  (ISO)
glomerulonephritis  (ISO)
Gram-Positive Bacterial Infections  (ISO)
Hearing Loss  (ISO)
hepatitis B  (ISO)
hepatocellular carcinoma  (ISO)
Herpes Simplex Encephalitis  (IEP,ISO)
herpes simplex virus keratitis  (ISO)
Human Influenza  (ISO)
Hyperalgesia  (IDA,ISO)
ileitis  (IMP)
Inflammation  (IDA,ISO)
invasive aspergillosis  (ISO)
keratitis  (IMP,ISO)
keratoconjunctivitis  (ISO)
kidney failure  (IEP)
Kidney Reperfusion Injury  (IDA,ISO)
Kuhnt-Junius degeneration  (ISO)
leprosy  (ISO)
leptospirosis  (ISO)
liver cirrhosis  (ISO)
Liver Reperfusion Injury  (IEP,ISO)
lung disease  (IDA,IEP,ISO)
mastoiditis  (ISO)
membranoproliferative glomerulonephritis  (ISO)
meningococcal meningitis  (ISO)
metabolic dysfunction-associated steatohepatitis  (ISO)
mite infestation  (ISO)
molluscum contagiosum  (ISO)
myelodysplastic syndrome  (ISO)
Myocardial Reperfusion Injury  (IEP)
Nasal Polyps  (ISO)
obesity  (ISO)
obstructive jaundice  (ISO)
Oral Lichen Planus  (ISO)
otitis media  (ISO)
Otitis Media with Effusion  (ISO)
Pain  (IDA)
pancreatitis  (IEP)
perinatal necrotizing enterocolitis  (IEP)
Plaque, Atherosclerotic  (ISO)
Pneumococcal Meningitis  (ISO)
Pneumococcal Pneumonia  (ISO)
pneumocystosis  (ISO)
pneumonia  (ISO)
prostate cancer  (ISO)
Pseudomonas Aeruginosa Keratitis  (ISO)
psoriasis  (ISO)
pulmonary emphysema  (ISO)
pulmonary fibrosis  (ISO)
pulmonary sarcoidosis  (ISO)
pulmonary tuberculosis  (ISO)
renal fibrosis  (IMP)
Reperfusion Injury  (IEP,ISO)
respiratory syncytial virus infectious disease  (ISO)
rheumatoid arthritis  (ISO)
rhinitis  (ISO)
Rhinosinusitis  (ISO)
sciatic neuropathy  (ISO)
seborrheic dermatitis  (ISO)
Sepsis  (IEP)
severe acute respiratory syndrome  (ISO)
sinusitis  (ISO)
skin papilloma  (ISO)
Staphylococcal Infections  (ISO)
Streptococcal Infections  (ISO)
suppurative otitis media  (ISO)
Transplant Rejection  (IEP,ISO)
tuberculosis  (ISO)
type 1 diabetes mellitus  (ISO)
typhoid fever  (ISO)
urinary bladder cancer  (ISO)
urinary tract infection  (ISO)
visceral leishmaniasis  (ISO)
vitiligo  (ISO)
Wallerian Degeneration  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(-)-citrinin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4,6-trinitrobenzene  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2,2-trichloroethanol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-mercaptopropanoic acid  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
adapalene  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
Aflatoxin G1  (ISO)
aldehydo-D-glucose  (ISO)
alfacalcidol  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
alpha-D-galactose  (EXP)
ammonium hexachloroplatinate  (ISO)
amphetamine  (EXP)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
astaxanthin  (ISO)
astemizole  (EXP)
atorvastatin calcium  (ISO)
azathioprine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisdemethoxycurcumin  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
bortezomib  (ISO)
butanal  (ISO)
butyric acid  (ISO)
cadmium dichloride  (EXP,ISO)
cannabidiol  (ISO)
carbon atom  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
cefoxitin  (ISO)
ceftaroline  (ISO)
cerium trichloride  (ISO)
CGP 52608  (ISO)
chitosan  (ISO)
chlorpyrifos  (EXP)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clothianidin  (ISO)
cobalt atom  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cordycepin  (ISO)
corilagin  (ISO)
cortisol  (ISO)
crocidolite asbestos  (ISO)
curcumin  (EXP,ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cyproconazole  (ISO)
D-glucose  (ISO)
deoxynivalenol  (ISO)
diarsenic trioxide  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (EXP,ISO)
dioxygen  (EXP,ISO)
disodium selenite  (ISO)
dopamine  (EXP)
doxorubicin  (EXP,ISO)
elemental carbon  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethylparaben  (ISO)
fenoldopam  (EXP)
ferric oxide  (ISO)
ferulic acid  (ISO)
fipronil  (EXP)
folic acid  (ISO)
fonofos  (ISO)
fructose  (ISO)
furan  (EXP)
galactose  (EXP)
genistein  (ISO)
gentamycin  (EXP,ISO)
glucose  (ISO)
glutathione  (ISO)
glycidol  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
graphene oxide  (ISO)
hexamethylene diisocyanate  (ISO)
histamine  (ISO)
hyaluronic acid  (ISO)
hydroxycitronellal  (ISO)
icosanoid  (ISO)
indometacin  (EXP,ISO)
indoprofen  (ISO)
irinotecan  (ISO)
iron(2+) sulfate (anhydrous)  (ISO)
isoeugenol  (ISO)
ivermectin  (ISO)
kaempferol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside  (ISO)
L-ascorbic acid  (ISO)
lead(0)  (ISO)
levamisole  (ISO)
lipophosphoglycan  (ISO)
lipopolysaccharide  (EXP,ISO)
lipoteichoic acid  (ISO)
lycopene  (ISO)
metformin  (ISO)
methamphetamine  (EXP,ISO)
methotrexate  (EXP,ISO)
methylseleninic acid  (ISO)
metronidazole  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
morphine  (ISO)
muramyl dipeptide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nitrites  (ISO)
nitroprusside  (ISO)
o-anisidine  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
parathion  (ISO)
pentachlorophenol  (ISO)
pentanal  (ISO)
pentane-2,3-dione  (EXP)
peptidoglycan  (ISO)
phenobarbital  (ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
poly(I:C)  (ISO)
prednisolone  (ISO)
progesterone  (ISO)
propanal  (ISO)
propiconazole  (ISO)
prostaglandin E2  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 203580  (ISO)
SCH 23390  (EXP)
silicon dioxide  (EXP,ISO)
simvastatin  (ISO)
sodium acetate trihydrate  (ISO)
sodium aurothiomalate  (ISO)
sodium dichromate  (EXP)
sodium dodecyl sulfate  (ISO)
sodium propionate  (ISO)
sulfasalazine  (ISO)
sulfur dioxide  (ISO)
sulindac  (EXP)
tacrolimus hydrate  (ISO)
terbufos  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thymoquinone  (EXP)
tibolone  (ISO)
Timosaponin b ii  (ISO)
titanium atom  (EXP)
titanium dioxide  (EXP,ISO)
topotecan  (EXP)
trans-isoeugenol  (ISO)
tributyrin  (EXP)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
Tungsten carbide  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vitamin D  (ISO)
vorinostat  (ISO)
zinc oxide  (ISO)
zinc protoporphyrin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell surface pattern recognition receptor signaling pathway  (ISO)
cellular response to bacterial lipopeptide  (ISO)
cellular response to diacyl bacterial lipopeptide  (ISO)
cellular response to lipoteichoic acid  (ISO)
cellular response to peptidoglycan  (ISO)
cellular response to triacyl bacterial lipopeptide  (ISO)
cellular response to type II interferon  (ISO)
central nervous system myelin formation  (IDA)
defense response  (ISO)
defense response to Gram-positive bacterium  (ISO)
defense response to virus  (IEA)
detection of diacyl bacterial lipopeptide  (ISO)
detection of triacyl bacterial lipopeptide  (ISO)
ERK1 and ERK2 cascade  (ISO)
immune response  (NAS)
inflammatory response  (IBA)
learning  (ISO)
leukocyte migration  (ISO)
leukotriene metabolic process  (IDA)
microglia development  (ISO)
microglial cell activation  (IDA)
MyD88-dependent toll-like receptor signaling pathway  (ISO)
negative regulation of actin filament polymerization  (ISO)
negative regulation of cell population proliferation  (IDA)
negative regulation of interleukin-12 production  (ISO)
negative regulation of interleukin-17 production  (ISO)
negative regulation of phagocytosis  (ISO)
negative regulation of synapse assembly  (ISO)
neutrophil migration  (ISO)
nitric oxide biosynthetic process  (ISO)
nitric oxide metabolic process  (IDA)
positive regulation of cellular response to macrophage colony-stimulating factor stimulus  (ISO)
positive regulation of chemokine production  (ISO)
positive regulation of cytokine production  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of inflammatory response  (ISO)
positive regulation of interferon-beta production  (ISO)
positive regulation of interleukin-1 beta production  (ISO)
positive regulation of interleukin-10 production  (IDA)
positive regulation of interleukin-12 production  (ISO)
positive regulation of interleukin-18 production  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of interleukin-8 production  (ISO)
positive regulation of intracellular signal transduction  (ISO)
positive regulation of leukocyte migration  (ISO)
positive regulation of macrophage cytokine production  (ISO)
positive regulation of matrix metallopeptidase secretion  (ISO)
positive regulation of neutrophil migration  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of nitric-oxide synthase biosynthetic process  (ISO)
positive regulation of non-canonical NF-kappaB signal transduction  (ISO)
positive regulation of oligodendrocyte differentiation  (IDA)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of Wnt signaling pathway  (ISO)
positive regulation of xenophagy  (ISO)
regulation of dendritic cell cytokine production  (ISO)
response to bacterial lipoprotein  (IDA)
response to bacterium  (ISO)
response to fatty acid  (IDA)
response to hypoxia  (IEP)
response to insulin  (IEP)
response to lipopolysaccharide  (IEP)
response to molecule of fungal origin  (ISO)
response to peptidoglycan  (ISO)
response to progesterone  (IEP)
response to toxic substance  (IEP)
toll-like receptor 2 signaling pathway  (ISO)
toll-like receptor signaling pathway  (IBA,IDA,IMP,ISO)
toll-like receptor TLR6:TLR2 signaling pathway  (ISO)
xenophagy  (ISO)

References

References - curated
# Reference Title Reference Citation
1. [Changes of Toll-like Receptor mRNA and Related Cytokines in Patients with Hepatic Alveolar Echinococcosis]. Abudusalamu A, etal., Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2016 Dec;34(6):542-6.
2. Serum Toll-Like Receptor-2, Toll-Like Receptor-4 Levels in Patients with HBeAg-Negative Chronic Viral Hepatitis B. Akbal E, etal., Viral Immunol. 2017 May;30(4):278-282. doi: 10.1089/vim.2016.0131. Epub 2017 Apr 17.
3. Complement activation and toll-like receptor-2 signaling contribute to cytokine production after renal ischemia/reperfusion. Amura CR, etal., Mol Immunol. 2012 Oct;52(3-4):249-57. doi: 10.1016/j.molimm.2012.05.020. Epub 2012 Jun 27.
4. Pivotal advance: HMGB1 expression in active lesions of human and experimental multiple sclerosis. Andersson A, etal., J Leukoc Biol. 2008 Nov;84(5):1248-55. Epub 2008 Jul 21.
5. Immunolocalization of toll-like receptor 2 in viral warts and molluscum contagiosum. Bakry OA, etal., Anal Quant Cytol Histol. 2013 Dec;35(6):316-23.
6. Involvement of toll-like receptor 2 in experimental invasive pulmonary aspergillosis. Balloy V, etal., Infect Immun. 2005 Sep;73(9):5420-5.
7. TLR4 links podocytes with the innate immune system to mediate glomerular injury. Banas MC, etal., J Am Soc Nephrol. 2008 Apr;19(4):704-13. doi: 10.1681/ASN.2007040395. Epub 2008 Feb 6.
8. Toll-like-receptor gene polymorphisms in a Tunisian population with Behcet's disease. Ben Dhifallah I, etal., Clin Exp Rheumatol. 2009 Mar-Apr;27(2 Suppl 53):S58-62.
9. Influence of perineurial cells and Toll-like receptors 2 and 9 on Herpes simplex type 1 entry to the central nervous system in rat encephalitis. Bereczky-Veress B, etal., PLoS One. 2010 Aug 27;5(8):e12350.
10. A TLR2 polymorphism is associated with type 1 diabetes and allergic asthma. Bjornvold M, etal., Genes Immun. 2009 Mar;10(2):181-7. Epub 2009 Jan 15.
11. Toll-like receptor 2 (TLR2) polymorphisms are associated with reversal reaction in leprosy. Bochud PY, etal., J Infect Dis. 2008 Jan 15;197(2):253-61. doi: 10.1086/524688.
12. Toll-like receptor signaling is critical for Wallerian degeneration and functional recovery after peripheral nerve injury. Boivin A, etal., J Neurosci. 2007 Nov 14;27(46):12565-76.
13. Differential regulation of Toll-like receptor mRNAs in experimental murine central nervous system infections. Bottcher T, etal., Neurosci Lett. 2003 Jun 19;344(1):17-20.
14. MyD88 signaling pathway is involved in renal fibrosis by favoring a TH2 immune response and activating alternative M2 macrophages. Braga TT, etal., Mol Med. 2012 Oct 24;18:1231-9. doi: 10.2119/molmed.2012.00131.
15. A rare polymorphism in the gene for Toll-like receptor 2 is associated with systemic sclerosis phenotype and increases the production of inflammatory mediators. Broen JC, etal., Arthritis Rheum. 2012 Jan;64(1):264-71. doi: 10.1002/art.33325.
16. TLR2 stimulation of intrinsic renal cells in the induction of immune-mediated glomerulonephritis. Brown HJ, etal., J Immunol. 2006 Aug 1;177(3):1925-31.
17. R753Q single-nucleotide polymorphism impairs toll-like receptor 2 recognition of hepatitis C virus core and nonstructural 3 proteins. Brown RA, etal., Transplantation. 2010 Apr 15;89(7):811-5. doi: 10.1097/TP.0b013e3181cbac18.
18. Toll-like receptors 2 and 3 agonists differentially affect oligodendrocyte survival, differentiation, and myelin membrane formation. Bsibsi M, etal., J Neurosci Res. 2012 Feb;90(2):388-98. doi: 10.1002/jnr.22767. Epub 2011 Oct 4.
19. Toll like receptor-2 modulates both innate and adaptive immune responses during chronic fungal asthma in mice. Buckland KF, etal., Inflamm Res. 2008 Aug;57(8):379-87.
20. Inhibition of toll-like receptor 2 expression improves insulin sensitivity and signaling in muscle and white adipose tissue of mice fed a high-fat diet. Caricilli AM, etal., J Endocrinol. 2008 Dec;199(3):399-406. Epub 2008 Sep 11.
21. TLR2, TLR4 and the MYD88 signaling pathway are crucial for neutrophil migration in acute kidney injury induced by sepsis. Castoldi A, etal., PLoS One. 2012;7(5):e37584. doi: 10.1371/journal.pone.0037584. Epub 2012 May 24.
22. Changes in Toll-like receptor (TLR)-2 and TLR4 expression and function but not polymorphisms are associated with acute anterior uveitis. Chang JH, etal., Invest Ophthalmol Vis Sci. 2007 Apr;48(4):1711-7.
23. TLR4- and TLR2-mediated B cell responses control the clearance of the bacterial pathogen, Leptospira interrogans. Chassin C, etal., J Immunol. 2009 Aug 15;183(4):2669-77. doi: 10.4049/jimmunol.0900506. Epub 2009 Jul 27.
24. Progesterone administration modulates TLRs/NF-kappaB signaling pathway in rat brain after cortical contusion. Chen G, etal., Ann Clin Lab Sci. 2008 Winter;38(1):65-74.
25. Engagement of Toll-like receptor 2 on CD4(+) T cells facilitates local immune responses in patients with tuberculous pleurisy. Chen X, etal., J Infect Dis. 2009 Aug 1;200(3):399-408.
26. Toll-like receptor 2 gene polymorphisms, pulmonary tuberculosis, and natural killer cell counts. Chen YC, etal., BMC Med Genet. 2010 Jan 30;11:17.
27. Staphylococcus aureus accelerates an experimental allergic conjunctivitis by Toll-like receptor 2-dependent manner. Chung SH, etal., Clin Immunol. 2009 Apr;131(1):170-7.
28. Nasal polyps in patients with and without cystic fibrosis: a differentiation by innate markers and inflammatory mediators. Claeys S, etal., Clin Exp Allergy. 2005 Apr;35(4):467-72.
29. Toll-like receptor 2 expression on human conjunctival epithelial cells: a pathway for Staphylococcus aureus involvement in chronic ocular proinflammatory responses. Cook EB, etal., Ann Allergy Asthma Immunol. 2005 Apr;94(4):486-97.
30. Pivotal role of Toll-like receptors 2 and 4, its adaptor molecule MyD88, and inflammasome complex in experimental tubule-interstitial nephritis. Correa-Costa M, etal., PLoS One. 2011;6(12):e29004. doi: 10.1371/journal.pone.0029004. Epub 2011 Dec 14.
31. HCV-related liver and lymphoproliferative diseases: association with polymorphisms of IL28B and TLR2. De Re V, etal., Oncotarget. 2016 Jun 21;7(25):37487-37497. doi: 10.18632/oncotarget.9303.
32. Role of Toll-like receptors 2 and 4 in pulmonary inflammation and injury induced by pneumolysin in mice. Dessing MC, etal., PLoS One. 2009 Nov 24;4(11):e7993.
33. Knockout of toll-like receptor-2 attenuates both the proinflammatory state of diabetes and incipient diabetic nephropathy. Devaraj S, etal., Arterioscler Thromb Vasc Biol. 2011 Aug;31(8):1796-804. doi: 10.1161/ATVBAHA.111.228924. Epub 2011 May 26.
34. Increased toll-like receptor (TLR) 2 and TLR4 expression in monocytes from patients with type 1 diabetes: further evidence of a proinflammatory state. Devaraj S, etal., J Clin Endocrinol Metab. 2008 Feb;93(2):578-83. Epub 2007 Nov 20.
35. Systemic up-regulation of TLR4 causes lipopolysaccharide-induced augmentation of nasal cytokine release in allergic rhinitis. Ekman AK, etal., Int Arch Allergy Immunol. 2012;159(1):6-14. doi: 10.1159/000335196. Epub 2012 Apr 27.
36. Association of TLR2 gene polymorphisms with ocular Behcet's disease in a Chinese Han population. Fang J, etal., Invest Ophthalmol Vis Sci. 2013 Dec 30;54(13):8384-92. doi: 10.1167/iovs.13-12878.
37. Inhibition of TLR2 promotes graft function in a murine model of renal transplant ischemia-reperfusion injury. Farrar CA, etal., FASEB J. 2012 Feb;26(2):799-807. doi: 10.1096/fj.11-195396. Epub 2011 Oct 31.
38. Expression of toll-like receptor 2 on peripheral blood monocytes of patients with inflammatory and noninflammatory acne vulgaris. Fathy A, etal., Egypt J Immunol. 2009;16(1):127-34.
39. Stem cell therapy for arterial restenosis: potential parameters contributing to the success of bone marrow-derived mesenchymal stromal cells. Forte A, etal., Cardiovasc Drugs Ther. 2012 Feb;26(1):9-21. doi: 10.1007/s10557-011-6359-8.
40. Up-regulation of Toll-like receptors 2, 3 and 4 in allergic rhinitis. Fransson M, etal., Respir Res. 2005 Sep 7;6:100.
41. Differential effect of insulin treatment on decreased levels of beta-defensins and Toll-like receptors in diabetic rats. Froy O, etal., Mol Immunol. 2007 Feb;44(5):796-802. Epub 2006 Jun 5.
42. A Toll-like receptor 2/6 agonist reduces allergic airway inflammation in chronic respiratory sensitisation to Timothy grass pollen antigens. Fuchs B, etal., Int Arch Allergy Immunol. 2010;152(2):131-9. Epub 2009 Dec 16.
43. Choroidal neovascularization enhanced by Chlamydia pneumoniae via Toll-like receptor 2 in the retinal pigment epithelium. Fujimoto T, etal., Invest Ophthalmol Vis Sci. 2010 Sep;51(9):4694-702. doi: 10.1167/iovs.09-4464. Epub 2010 Apr 14.
44. Disordered Toll-like receptor 2 responses in the pathogenesis of pulmonary sarcoidosis. Gabrilovich MI, etal., Clin Exp Immunol. 2013 Sep;173(3):512-22. doi: 10.1111/cei.12138.
45. GSK-3beta inhibitor modulates TLR2/NF-kappaB signaling following myocardial ischemia-reperfusion. Gao HK, etal., Inflamm Res. 2009 Mar 10.
46. Increased gene expression of Toll-like receptor 4 on peripheral blood mononuclear cells in patients with psoriasis. Garcia-Rodriguez S, etal., J Eur Acad Dermatol Venereol. 2013 Feb;27(2):242-50.
47. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
48. Toll-like receptor 2 regulates CXC chemokine production and neutrophil recruitment to the cornea in Onchocerca volvulus/Wolbachia-induced keratitis. Gillette-Ferguson I, etal., Infect Immun. 2007 Dec;75(12):5908-15. Epub 2007 Sep 17.
49. Toll-like receptor 2 siRNA suppresses corneal inflammation and attenuates Aspergillus fumigatus keratitis in rats. Guo H, etal., Immunol Cell Biol. 2012 Mar;90(3):352-7. doi: 10.1038/icb.2011.49. Epub 2011 Jun 7.
50. Combinations of TLR and NOD2 ligands stimulate rat microglial P2X4R expression. Guo LH, etal., Biochem Biophys Res Commun. 2006 Oct 27;349(3):1156-62. Epub 2006 Sep 1.
51. Importance of TLR2 in early innate immune response to acute pulmonary infection with Porphyromonas gingivalis in mice. Hajishengallis G, etal., J Immunol. 2008 Sep 15;181(6):4141-9.
52. Role for Toll-like receptor 2 in the immune response to Streptococcus pneumoniae infection in mouse otitis media. Han F, etal., Infect Immun. 2009 Jul;77(7):3100-8. doi: 10.1128/IAI.00204-09. Epub 2009 May 4.
53. Selective impairment of Toll-like receptor 2-mediated proinflammatory cytokine production by monocytes from patients with atopic dermatitis. Hasannejad H, etal., J Allergy Clin Immunol. 2007 Jul;120(1):69-75. Epub 2007 May 25.
54. Toll-like receptor 2-mediated NF-kappaB inflammatory responses in dry eye associated with cGVHD. He C, etal., Mol Vis. 2011;17:2605-11. Epub 2011 Oct 5.
55. Tlr2 is critical for diet-induced metabolic syndrome in a murine model. Himes RW and Smith CW, FASEB J. 2010 Mar;24(3):731-9. doi: 10.1096/fj.09-141929. Epub 2009 Oct 19.
56. Expression of toll-like receptors in chronic otitis media and cholesteatoma. Hirai H, etal., Int J Pediatr Otorhinolaryngol. 2013 May;77(5):674-6. doi: 10.1016/j.ijporl.2013.01.010. Epub 2013 Feb 4.
57. Impact of Toll-like receptor 2 expression in renal allograft rejection. Hoffmann U, etal., Nephrol Dial Transplant. 2011 Mar;26(3):1080-7. doi: 10.1093/ndt/gfq420. Epub 2010 Jul 13.
58. Aberrant expression and dysfunction of TLR2 and its soluble form in chronic HBV infection and its regulation by antiviral therapy. Huang Z, etal., Antiviral Res. 2015 Jun;118:10-9. doi: 10.1016/j.antiviral.2015.03.004. Epub 2015 Mar 12.
59. Pyrexia, anorexia, adipsia, and depressed motor activity in rats during systemic inflammation induced by the Toll-like receptors-2 and -6 agonists MALP-2 and FSL-1. Hubschle T, etal., Am J Physiol Regul Integr Comp Physiol. 2006 Jan;290(1):R180-7. Epub 2005 Sep 8.
60. Toll-like receptor 2 is highly expressed in lesions of acne inversa and colocalizes with C-type lectin receptor. Hunger RE, etal., Br J Dermatol. 2008 Apr;158(4):691-7. doi: 10.1111/j.1365-2133.2007.08425.x. Epub 2008 Jan 30.
61. Toll-like receptor 2 and Toll-like receptor 4 polymorphisms and susceptibility to asthma and allergic rhinitis: a case-control analysis. Hussein YM, etal., Cell Immunol. 2012;274(1-2):34-8. doi: 10.1016/j.cellimm.2012.02.006. Epub 2012 Feb 17.
62. The role of infection in the development of non-valvular atrial fibrillation: up-regulation of Toll-like receptor 2 expression levels on monocytes. Ichiki H, etal., J Cardiol. 2009 Feb;53(1):127-35. doi: 10.1016/j.jjcc.2008.09.008. Epub 2008 Nov 25.
63. Double blind clinical trial in a series of 115 patients with seborrheic dermatitis: prevention of relapses using a topical modulator of Toll like receptor 2. Ionescu MA, etal., G Ital Dermatol Venereol. 2011 Jun;146(3):185-9.
64. Expression of Toll-Like Receptors 2, 4 and Nuclear Factor Kappa B in Mucosal Lesions of Human Otitis: Pattern and Relationship in a Clinical Immunohistochemical Study. Jesic S, etal., Ann Otol Rhinol Laryngol. 2014 Apr 1.
65. Toll like receptor 2 knock-out attenuates carbon tetrachloride (CCl4)-induced liver fibrosis by downregulating MAPK and NF-κB signaling pathways. Ji L, etal., FEBS Lett. 2014 Jun 5;588(12):2095-100. doi: 10.1016/j.febslet.2014.04.042. Epub 2014 May 8.
66. Activation of Toll-like receptors 2 and 4 in Aspergillus fumigatus keratitis. Jie Zhao, etal., Innate Immun. 2009 Jun;15(3):155-68.
67. Expression of toll-like receptors in the Fusarium solani infected cornea. Jin X, etal., Curr Eye Res. 2008 Apr;33(4):319-24. doi: 10.1080/02713680802008238.
68. The delayed response of Toll-like receptors may relate to Pseudomonas aeruginosa keratitis exacerbating rapidly at the early stages of infection. Jin X, etal., Eur J Clin Microbiol Infect Dis. 2010 Feb;29(2):231-8. doi: 10.1007/s10096-009-0844-z. Epub 2009 Dec 13.
69. [Effects of intestinal trefoil factor on Toll-like receptors 2 and 4 expression in intestinal tissue in young rats with endotoxemia]. Jing K and Sun M, Zhongguo Dang Dai Er Ke Za Zhi. 2011 Dec;13(12):985-8.
70. Gut microbiota regulate hepatic von Willebrand factor synthesis and arterial thrombus formation via Toll-like receptor-2. Jäckel S, etal., Blood. 2017 Jul 27;130(4):542-553. doi: 10.1182/blood-2016-11-754416. Epub 2017 Jun 1.
71. Toll-like receptor 2 expression level on monocytes in patients with viral infections: monitoring infection severity. Kajiya T, etal., J Infect. 2008 Sep;57(3):249-59. Epub 2008 Jul 26.
72. Identification of polymorphisms in the Toll-like receptor gene and the association with allergic rhinitis. Kang I, etal., Eur Arch Otorhinolaryngol. 2010 Mar;267(3):385-9. Epub 2009 Sep 18.
73. TLR2 and TLR4 gene polymorphisms in Turkish vitiligo patients. Karaca N, etal., J Eur Acad Dermatol Venereol. 2013 Jan;27(1):e85-90. doi: 10.1111/j.1468-3083.2012.04514.x. Epub 2012 Mar 16.
74. Beneficial effects of TLR-2/6 ligation in pulmonary bacterial infection and immunization with Pseudomonas aeruginosa. Kerber-Momot T, etal., Inflammation. 2010 Feb;33(1):58-64.
75. Toll-like receptor 2 and 4 genes influence susceptibility to adverse effects of traffic-related air pollution on childhood asthma. Kerkhof M, etal., Thorax. 2010 Aug;65(8):690-7.
76. Delayed administration of pituitary adenylate cyclase-activating polypeptide 38 ameliorates renal ischemia/reperfusion injury in mice by modulating Toll-like receptors. Khan AM, etal., Peptides. 2012 Dec;38(2):395-403. doi: 10.1016/j.peptides.2012.09.023. Epub 2012 Sep 28.
77. Toll-like receptor 2 modulates the proinflammatory milieu in Staphylococcus aureus-induced brain abscess. Kielian T, etal., Infect Immun. 2005 Nov;73(11):7428-35.
78. Ischemia-reperfusion injury activates innate immunity in rat kidneys. Kim BS, etal., Transplantation. 2005 May 27;79(10):1370-7.
79. A critical role of toll-like receptor 2 in nerve injury-induced spinal cord glial cell activation and pain hypersensitivity. Kim D, etal., J Biol Chem. 2007 May 18;282(20):14975-83. Epub 2007 Mar 13.
80. Expression of TLR2, TLR4, and TLR9 in dermatomyositis and polymyositis. Kim GT, etal., Clin Rheumatol. 2010 Mar;29(3):273-9. doi: 10.1007/s10067-009-1316-7. Epub 2009 Dec 2.
81. Toll-like receptor 2 senses beta-cell death and contributes to the initiation of autoimmune diabetes. Kim HS, etal., Immunity. 2007 Aug;27(2):321-33. Epub 2007 Aug 16.
82. Macrophage-activating lipopeptide-2 (MALP-2) induces a localized inflammatory response in rats resulting in activation of brain sites implicated in fever. Knorr C, etal., Brain Res. 2008 Apr 18;1205:36-46. Epub 2008 Feb 21.
83. Toll-like receptor expression in monocytes in patients with chronic kidney disease and haemodialysis: relation with inflammation. Koc M, etal., Nephrol Dial Transplant. 2011 Mar;26(3):955-63. doi: 10.1093/ndt/gfq500. Epub 2010 Aug 20.
84. Elucidating the molecular physiopathology of acute respiratory distress syndrome in severe acute respiratory syndrome patients. Kong SL, etal., Virus Res. 2009 Nov;145(2):260-9. Epub 2009 Jul 25.
85. Toll-like receptor 2 ligand-induced protection against bacterial endophthalmitis. Kumar A, etal., J Infect Dis. 2010 Jan 15;201(2):255-63. doi: 10.1086/649589.
86. Pathogen recognition by the innate immune system. Kumar H, etal., Int Rev Immunol. 2011 Feb;30(1):16-34.
87. Herpes simplex virus 1 interaction with Toll-like receptor 2 contributes to lethal encephalitis. Kurt-Jones EA, etal., Proc Natl Acad Sci U S A. 2004 Feb 3;101(5):1315-20. Epub 2004 Jan 22.
88. TLR 2 and 4 responsiveness from isolated peripheral blood mononuclear cells from rats and humans as potential chronic pain biomarkers. Kwok YH, etal., PLoS One. 2013 Oct 30;8(10):e77799. doi: 10.1371/journal.pone.0077799. eCollection 2013.
89. The role of Toll-like receptor 2 in inflammation and fibrosis during progressive renal injury. Leemans JC, etal., PLoS One. 2009 May 27;4(5):e5704. doi: 10.1371/journal.pone.0005704.
90. TLR2-dependent MyD88 signaling contributes to early host defense in murine Enterococcus faecium peritonitis. Leendertse M, etal., J Immunol. 2008 Apr 1;180(7):4865-74.
91. TLR4-mediated induction of TLR2 signaling is critical in the pathogenesis and resolution of otitis media. Leichtle A, etal., Innate Immun. 2009 Aug;15(4):205-15. doi: 10.1177/1753425909103170. Epub 2009 Jul 8.
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93. [Toll-like receptor 2 and Toll-like receptor 4 participates in mediation of acute otitis media and mortality in pneumococcal infections in mice]. Li SL, etal., Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2011 Dec;46(12):1009-18.
94. Quercetin attenuates the activation of hepatic stellate cells and liver fibrosis in mice through modulation of HMGB1-TLR2/4-NF-κB signaling pathways. Li X, etal., Toxicol Lett. 2016 Nov 2;261:1-12. doi: 10.1016/j.toxlet.2016.09.002. Epub 2016 Sep 4.
95. Cyclosporine-induced renal injury induces toll-like receptor and maturation of dendritic cells. Lim SW, etal., Transplantation. 2005 Sep 15;80(5):691-9.
96. Loss of immunity-supported senescence enhances susceptibility to hepatocellular carcinogenesis and progression in Toll-like receptor 2-deficient mice. Lin H, etal., Hepatology. 2013 Jan;57(1):171-82. doi: 10.1002/hep.25991.
97. Pre-Activation of Toll-Like Receptor 2 Enhances CD8+ T-Cell Responses and Accelerates Hepatitis B Virus Clearance in the Mouse Models. Lin Y, etal., Front Immunol. 2018 Jun 29;9:1495. doi: 10.3389/fimmu.2018.01495. eCollection 2018.
98. MicroRNA-29a mitigation of toll-like receptor 2 and 4 signaling and alleviation of obstructive jaundice-induced fibrosis in mice. Lin YC, etal., Biochem Biophys Res Commun. 2018 Feb 12;496(3):880-886. doi: 10.1016/j.bbrc.2018.01.132. Epub 2018 Jan 31.
99. Erythropoietin pretreatment exerts anti-inflammatory effects in hepatic ischemia/reperfusion-injured rats via suppression of the TLR2/NF-κB pathway. Liu QS, etal., Transplant Proc. 2015 Mar;47(2):283-9. doi: 10.1016/j.transproceed.2014.10.045.
100. Hepatocyte toll-like receptor 2 expression in vivo and in vitro: role of cytokines in induction of rat TLR2 gene expression by lipopolysaccharide. Liu S, etal., Shock. 2000 Sep;14(3):361-5.
101. Toll-like receptor 2 plays a critical role in the progression of atherosclerosis that is independent of dietary lipids. Liu X, etal., Atherosclerosis. 2008 Jan;196(1):146-54. Epub 2007 Apr 26.
102. Higher expression of Toll-like receptors 2, 3, 4, and 8 in ocular Behcet's disease. Liu X, etal., Invest Ophthalmol Vis Sci. 2013 Sep 5;54(9):6012-7. doi: 10.1167/iovs.13-12159.
103. Changes in intestinal Toll-like receptors and cytokines precede histological injury in a rat model of necrotizing enterocolitis. Liu Y, etal., Am J Physiol Gastrointest Liver Physiol. 2009 Sep;297(3):G442-50. Epub 2009 Jul 16.
104. Relationship between expression of toll-like receptors 2/4 in dendritic cells and chronic hepatitis B virus infection. Lu X, etal., Int J Clin Exp Pathol. 2014 Aug 15;7(9):6048-55. eCollection 2014.
105. [Effects of antimicrobial agents on the Toll like receptors and myeloid differentiation protein-2 in liver tissue of alcohol-induced liver disease: experiment with rats] Lu ZQ, etal., Zhonghua Yi Xue Za Zhi. 2009 Jan 13;89(2):138-41.
106. Gut microbiota translocation promotes autoimmune cholangitis. Ma HD, etal., J Autoimmun. 2018 Dec;95:47-57. doi: 10.1016/j.jaut.2018.09.010. Epub 2018 Oct 17.
107. Association of Toll-like receptor (TLR) 2, 3 and 9 genes polymorphism with prostate cancer risk in North Indian population. Mandal RK, etal., Mol Biol Rep. 2012 Jul;39(7):7263-9. doi: 10.1007/s11033-012-1556-5. Epub 2012 Feb 6.
108. Toll-like receptors in rat brains injured by hypoxic-ischaemia or exposed to staphylococcal alpha-toxin. Maslinska D, etal., Folia Neuropathol. 2004;42(3):125-32.
109. Temperature- and time-dependent changes in TLR2-activated microglial NF-kappaB activity and concentrations of inflammatory and anti-inflammatory factors. Matsui T, etal., Intensive Care Med. 2012 Aug;38(8):1392-9. doi: 10.1007/s00134-012-2591-3. Epub 2012 Jun 1.
110. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
111. Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity. Milanski M, etal., J Neurosci. 2009 Jan 14;29(2):359-70.
112. In situ TLR2 and TLR4 expression in a murine model of mycetoma caused by Nocardia brasiliensis. Millan-Chiu BE, etal., FEMS Immunol Med Microbiol. 2011 Apr;61(3):278-87. doi: 10.1111/j.1574-695X.2010.00775.x. Epub 2011 Jan 31.
113. Deletion of Thioredoxin-interacting protein ameliorates high fat diet-induced non-alcoholic steatohepatitis through modulation of Toll-like receptor 2-NLRP3-inflammasome axis: Histological and immunohistochemical study. Mohamed IN, etal., Acta Histochem. 2018 Apr;120(3):242-254. doi: 10.1016/j.acthis.2018.02.006. Epub 2018 Feb 23.
114. A clinical association between Toll-like receptor 2 Arg753Gln polymorphism with recurrent cystic echinococcosis in postsurgery patients: A case control study. Moradkhani MA, etal., Comp Immunol Microbiol Infect Dis. 2019 Oct;66:101336. doi: 10.1016/j.cimid.2019.101336. Epub 2019 Jul 24.
115. Systemic activation of Toll-like receptor 2 suppresses mitochondrial respiration and exacerbates hypoxic-ischemic injury in the developing brain. Mottahedin A, etal., J Cereb Blood Flow Metab. 2017 Apr;37(4):1192-1198. doi: 10.1177/0271678X17691292. Epub 2017 Jan 1.
116. Respiratory syncytial virus activates innate immunity through Toll-like receptor 2. Murawski MR, etal., J Virol. 2009 Feb;83(3):1492-500. Epub 2008 Nov 19.
117. Regulatory actions of Toll-like receptor 2 (TLR2) and TLR4 in Leishmania donovani infection in the liver. Murray HW, etal., Infect Immun. 2013 Jul;81(7):2318-26. doi: 10.1128/IAI.01468-12. Epub 2013 Apr 15.
118. Involvement of innate immunity in the pathogenesis of intestinal Behcet's disease. Nara K, etal., Clin Exp Immunol. 2008 May;152(2):245-51. doi: 10.1111/j.1365-2249.2008.03626.x. Epub 2008 Mar 10.
119. The toll-like receptor 2 (TLR2) -196 to -174 del/ins polymorphism affects viral loads and susceptibility to hepatocellular carcinoma in chronic hepatitis C. Nischalke HD, etal., Int J Cancer. 2012 Mar 15;130(6):1470-5. doi: 10.1002/ijc.26143. Epub 2011 Jun 18.
120. Role of Toll-like receptor (TLR) 2 in experimental Bacillus cereus endophthalmitis. Novosad BD, etal., PLoS One. 2011;6(12):e28619. doi: 10.1371/journal.pone.0028619. Epub 2011 Dec 6.
121. Association of the toll-like receptor 2 A-16934T promoter polymorphism with severe atopic dermatitis. Oh DY, etal., Allergy. 2009 Nov;64(11):1608-15. doi: 10.1111/j.1398-9995.2009.02066.x. Epub 2009 Jul 21.
122. Enhanced expression of Toll-like receptor 2 in lesional tissues and peripheral blood monocytes of patients with oral lichen planus. Ohno S, etal., J Dermatol. 2011 Apr;38(4):335-44.
123. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
124. Toll-like receptor 2 gene polymorphisms in a Korean population: association with chronic rhinosinusitis. Park CS, etal., Otolaryngol Head Neck Surg. 2011 Jan;144(1):96-100. doi: 10.1177/0194599810390881.
125. Association of the polymorphism for Toll-like receptor 2 with type 1 diabetes susceptibility. Park Y, etal., Ann N Y Acad Sci. 2004 Dec;1037:170-4.
126. Toll-like receptor 2 is essential for the sensing of oxidants during inflammation. Paul-Clark MJ, etal., Am J Respir Crit Care Med. 2009 Feb 15;179(4):299-306. Epub 2008 Nov 14.
127. Combined Tlr2 and Tlr4 deficiency increases radiation-induced pulmonary fibrosis in mice. Paun A, etal., Int J Radiat Oncol Biol Phys. 2010 Jul 15;77(4):1198-205.
128. Surface TLR2 and TLR4 expression on mature rat mast cells can be affected by some bacterial components and proinflammatory cytokines. Pietrzak A, etal., Mediators Inflamm. 2011;2011:427473. doi: 10.1155/2011/427473. Epub 2011 May 2.
129. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
130. Toll-like receptor 2 deficiency is associated with enhanced severity of group B streptococcal disease. Puliti M, etal., Infect Immun. 2009 Apr;77(4):1524-31. doi: 10.1128/IAI.00965-08. Epub 2009 Jan 29.
131. Polymorphisms in the toll-like receptor 2 subfamily and risk of asthma: a case-control analysis in a Chinese population. Qian FH, etal., J Investig Allergol Clin Immunol. 2010;20(4):340-6.
132. Toll-like receptor expression and activation in mice with experimental dry eye. Redfern RL, etal., Invest Ophthalmol Vis Sci. 2013 Feb 28;54(2):1554-63. doi: 10.1167/iovs.12-10739.
133. GOA pipeline RGD automated data pipeline
134. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
135. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
136. Expression of toll-like receptors 2, 4 and 9 is increased in gingival tissue from patients with type 2 diabetes and chronic periodontitis. Rojo-Botello NR, etal., J Periodontal Res. 2012 Feb;47(1):62-73. doi: 10.1111/j.1600-0765.2011.01405.x. Epub 2011 Aug 17.
137. Nucleotide-binding oligomerization domain 2 and Toll-like receptor 2 function independently in a murine model of arthritis triggered by intraarticular peptidoglycan. Rosenzweig HL, etal., Arthritis Rheum. 2010 Apr;62(4):1051-9. doi: 10.1002/art.27335.
138. Toll-like receptors 2 and 4 in renal ischemia/reperfusion injury. Rusai K, etal., Pediatr Nephrol. 2010 May;25(5):853-60. doi: 10.1007/s00467-009-1422-4. Epub 2010 Feb 4.
139. TLR2 and TLR4 gene polymorphisms and atopic dermatitis in Italian children: a multicenter study. Salpietro C, etal., Int J Immunopathol Pharmacol. 2011 Oct;24(4 Suppl):33-40.
140. No association of TLR2 and TLR4 polymorphisms with type I diabetes mellitus in the Basque population. Santin I, etal., Ann N Y Acad Sci. 2006 Oct;1079:268-72.
141. Innate recognition network driving herpes simplex virus-induced corneal immunopathology: role of the toll pathway in early inflammatory events in stromal keratitis. Sarangi PP, etal., J Virol. 2007 Oct;81(20):11128-38. Epub 2007 Aug 8.
142. Expression of toll-like receptor 2 and 4 in intestinal mucosa in experimental severe acute pancreatitis. Sawa H, etal., Hepatogastroenterology. 2008 Nov-Dec;55(88):2247-51.
143. TLR2 and TLR4 expression in peripheral blood mononuclear cells of patients with chronic cystic echinococcosis and its relationship with IL-10. Shan JY, etal., Parasite Immunol. 2011 Dec;33(12):692-6. doi: 10.1111/j.1365-3024.2011.01335.x.
144. The role of TLR2 in nerve injury-induced neuropathic pain is essentially mediated through macrophages in peripheral inflammatory response. Shi XQ, etal., Glia. 2011 Feb;59(2):231-41. doi: 10.1002/glia.21093.
145. Mechanistic investigation of immunosuppression in patients with condyloma acuminata. Shi YJ, etal., Mol Med Rep. 2013 Aug;8(2):480-6. doi: 10.3892/mmr.2013.1511. Epub 2013 Jun 6.
146. [Differential expression of toll-like receptors in chronic suppurative otitis media and cholesteatoma]. Si Y, etal., Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2012 May;47(5):388-93.
147. Intestinal epithelial barrier dysfunction and dendritic cell redistribution during early stages of inflammation in the rat: role for TLR-2 and -4 blockage. Silva MA, etal., Inflamm Bowel Dis. 2008 May;14(5):632-44.
148. Single-nucleotide Polymorphisms in Genes Encoding Toll-like Receptor -2, -3, -4, and -9 in a Case-Control Study with Bladder Cancer Susceptibility in a North Indian Population. Singh V, etal., Arch Med Res. 2013 Jan;44(1):54-61. doi: 10.1016/j.arcmed.2012.10.008. Epub 2012 Nov 6.
149. CD14 and toll-like receptor gene polymorphisms, country living, and asthma in adults. Smit LA, etal., Am J Respir Crit Care Med. 2009 Mar 1;179(5):363-8. Epub 2008 Dec 18.
150. Toll-like receptor 2 induces Th17 myeloperoxidase autoimmunity while Toll-like receptor 9 drives Th1 autoimmunity in murine vasculitis. Summers SA, etal., Arthritis Rheum. 2011 Apr;63(4):1124-35. doi: 10.1002/art.30208.
151. Biofilm formation and Toll-like receptor 2, Toll-like receptor 4, and NF-kappaB expression in sinus tissues of patients with chronic rhinosinusitis. Sun Y, etal., Am J Rhinol Allergy. 2012 Mar-Apr;26(2):104-9. doi: 10.2500/ajra.2012.26.3718. Epub 2011 Dec 16.
152. Staphylococcus aureus-induced corneal inflammation is dependent on Toll-like receptor 2 and myeloid differentiation factor 88. Sun Y, etal., Infect Immun. 2006 Sep;74(9):5325-32.
153. Association of TLR2 gene Arg753Gln polymorphism with urinary tract infection in children. Tabel Y, etal., Int J Immunogenet. 2007 Dec;34(6):399-405.
154. [Methylprednisolone enhances the expression of Toll-like receptor 2 on macrophages in induced sputum from patients with chronic cough]. Tang CW, etal., Zhonghua Jie He He Hu Xi Za Zhi. 2011 Feb;34(2):123-7.
155. Assessment of Toll-like receptor 2 gene polymorphisms in severe chronic rhinosinusitis. Tewfik MA, etal., J Otolaryngol Head Neck Surg. 2008 Aug;37(4):552-8.
156. Toll-like receptors gene polymorphisms may confer increased susceptibility to breast cancer development. Theodoropoulos GE, etal., Breast. 2012 Aug;21(4):534-8. doi: 10.1016/j.breast.2012.04.001. Epub 2012 May 2.
157. Association study of tumor necrosis factor receptor type 2 M196R and toll-like receptor 2 Arg753Gln polymorphisms with acne vulgaris in a Chinese Han ethnic group. Tian LM, etal., Dermatology. 2010;221(3):276-84. doi: 10.1159/000319851.
158. Enhanced immediate inflammatory response to Streptococcus pneumoniae in the lungs of mice with pulmonary emphysema. Tokairin Y, etal., Respirology. 2008 May;13(3):324-32.
159. Involvement of toll-like receptor 2 and 4 in association between dyslipidemia and osteoclast differentiation in apolipoprotein E deficient rat periodontium. Tomofuji T, etal., Lipids Health Dis. 2013 Jan 8;12(1):1.
160. Protective effects of curcumin against hepatic fibrosis induced by carbon tetrachloride: modulation of high-mobility group box 1, Toll-like receptor 4 and 2 expression. Tu CT, etal., Food Chem Toxicol. 2012 Sep;50(9):3343-51. doi: 10.1016/j.fct.2012.05.050. Epub 2012 Jun 7.
161. Modulation of immune signaling, bacterial clearance, and corneal integrity by toll-like receptors during streptococcus pneumoniae keratitis. Tullos NA, etal., Curr Eye Res. 2013 Oct;38(10):1036-48. doi: 10.3109/02713683.2013.804094. Epub 2013 Jul 10.
162. The expression of TLR2, TLR4 and TLR9 in the epidermis of patients with cutaneous leishmaniasis. Tuon FF, etal., J Dermatol Sci. 2010 Jul;59(1):55-7. doi: 10.1016/j.jdermsci.2010.04.009. Epub 2010 May 20.
163. Polymorphisms in Toll-like receptors 2, 4, and 9 are highly associated with hearing loss in survivors of bacterial meningitis. van Well GT, etal., PLoS One. 2012;7(5):e35837. doi: 10.1371/journal.pone.0035837. Epub 2012 May 25.
164. Single nucleotide polymorphisms in pathogen recognition receptor genes are associated with susceptibility to meningococcal meningitis in a pediatric cohort. van Well GT, etal., PLoS One. 2013 May 14;8(5):e64252. doi: 10.1371/journal.pone.0064252. Print 2013.
165. Reduction of TLR2 gene expression in allergic and nonallergic rhinitis. Vanhinsbergh LJ, etal., Ann Allergy Asthma Immunol. 2007 Dec;99(6):509-16. doi: 10.1016/S1081-1206(10)60379-1.
166. Association of SLC11A1 with tuberculosis and interactions with NOS2A and TLR2 in African-Americans and Caucasians. Velez DR, etal., Int J Tuberc Lung Dis. 2009 Sep;13(9):1068-76.
167. [Expression of toll-like receptor mRNA in epithelial cell of nasal mucosa]. Wang CS and Dong Z, Zhonghua Er Bi Yan Hou Ke Za Zhi. 2003 Aug;38(4):243-6.
168. Recipient Toll-like receptors contribute to chronic graft dysfunction by both MyD88- and TRIF-dependent signaling. Wang S, etal., Dis Model Mech. 2010 Jan-Feb;3(1-2):92-103. doi: 10.1242/dmm.003533. Epub 2009 Dec 28.
169. Decreased inflammatory response in Toll-like receptor 2 knockout mice is associated with exacerbated Pneumocystis pneumonia. Wang SH, etal., Microbes Infect. 2008 Apr;10(4):334-41. Epub 2007 Dec 28.
170. Fever induction by systemic stimulation with macrophage-activating lipopeptide-2 depends upon TLR2 but not CD36. Welsch J, etal., Innate Immun. 2012 Jun;18(3):541-59. doi: 10.1177/1753425911426892. Epub 2011 Oct 31.
171. No evidence of altered alveolar macrophage polarization, but reduced expression of TLR2, in bronchoalveolar lavage cells in sarcoidosis. Wiken M, etal., Respir Res. 2010 Sep 2;11:121.
172. In vivo expression of Toll-like receptor 2 and 4 by renal epithelial cells: IFN-gamma and TNF-alpha mediated up-regulation during inflammation. Wolfs TG, etal., J Immunol. 2002 Feb 1;168(3):1286-93.
173. Effect of nitric oxide on toll-like receptor 2 and 4 gene expression in rats with acute lung injury complicated by acute hemorrhage necrotizing pancreatitis. Wu HS, etal., Hepatobiliary Pancreat Dis Int. 2005 Nov;4(4):609-13.
174. Toll-like receptor 2 down-regulation in established mouse allergic lungs contributes to decreased mycoplasma clearance. Wu Q, etal., Am J Respir Crit Care Med. 2008 Apr 1;177(7):720-9. Epub 2008 Jan 17.
175. Microsatellite polymorphisms in intron 2 of the toll-like receptor 2 gene and their association with susceptibility to pulmonary tuberculosis in Han Chinese. Xue Y, etal., Clin Chem Lab Med. 2010 Jun;48(6):785-9.
176. Targeting TLR2 attenuates pulmonary inflammation and fibrosis by reversion of suppressive immune microenvironment. Yang HZ, etal., J Immunol. 2009 Jan 1;182(1):692-702.
177. Different expression of dectin-1 and Toll-like receptor 2 in the lungs of different immune status mice infected with Aspergillus fumigatus. Yang JX, etal., Chin Med J (Engl). 2009 Sep 5;122(17):2017-21.
178. TLR2 signal influences the iNOS/NO responses and worm development in C57BL/6J mice infected with Clonorchis sinensis. Yang QL, etal., Parasit Vectors. 2017 Aug 7;10(1):379. doi: 10.1186/s13071-017-2318-y.
179. [Changes in Toll-like receptor 2 and 4 gene expression in vital organs in septic rats and their regulation mechanisms] Yao YM, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2003 Nov;15(11):646-50.
180. Association between microsatellite polymorphisms in intron II of the human Toll-like receptor 2 gene and nontuberculous mycobacterial lung disease in a Korean population. Yim JJ, etal., Hum Immunol. 2008 Sep;69(9):572-6. Epub 2008 Jul 3.
181. Toll-Like receptor 2 (TLR2) and TLR9 play opposing roles in host innate immunity against Salmonella enterica serovar Typhimurium infection. Zhan R, etal., Infect Immun. 2015 Apr;83(4):1641-9. doi: 10.1128/IAI.02870-14. Epub 2015 Feb 9.
182. Protection against hepatic ischemia/reperfusion injury via downregulation of toll-like receptor 2 expression by inhibition of Kupffer cell function. Zhang JX, etal., World J Gastroenterol. 2005 Jul 28;11(28):4423-6. doi: 10.3748/wjg.v11.i28.4423.
183. [Effect of nitric oxide on Toll-like receptor 2/4 gene expression in the liver in acute hemorrhagic necrotizing pancreatitis in rats] Zhang L, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2006 Mar;18(3):161-4.
184. Toll-like receptor-2, CD14 and heat-shock protein 70 in inflammatory lesions of rat experimental autoimmune neuritis. Zhang ZY, etal., Neuroscience. 2009 Mar 3;159(1):136-42. Epub 2009 Jan 1.
185. Effects of Fufang Shenhua Tablet on the expression of toll-like receptors during acute kidney injury induced by ischemia-reperfusion in rats. Zheng XY, etal., Chin J Integr Med. 2012 Dec;18(12):918-24. doi: 10.1007/s11655-012-1295-1. Epub 2012 Dec 13.
186. A synthetic Toll-like receptor 2 ligand decreases allergic immune responses in a mouse rhinitis model sensitized to mite allergen. Zhou C, etal., J Zhejiang Univ Sci B. 2008 Apr;9(4):279-85. doi: 10.1631/jzus.B0730029.
187. Induction of toll-like receptor 2 positive antigen-presenting cells in spleen of pristane-induced arthritis in rats. Zhu W, etal., Mol Biol Rep. 2012 Apr;39(4):3667-73. doi: 10.1007/s11033-011-1141-3. Epub 2011 Jul 3.
188. Increase in peripheral blood mononuclear cell Toll-like receptor 2/3 expression and reactivity to their ligands in a cohort of patients with wet age-related macular degeneration. Zhu Y, etal., Mol Vis. 2013 Aug 6;19:1826-33. eCollection 2013.
189. [Effects of vasoactive intestinal peptide on Toll-like receptor (TLR) 2 mRNA and TLR4 mRNA expression on acute lung injury induced by lipopolysach aride in rat] Zuo WQ, etal., Zhonghua Er Ke Za Zhi. 2010 Jan;48(1):19-23.
Additional References at PubMed
PMID:10384090   PMID:10549626   PMID:11067888   PMID:11274165   PMID:11521063   PMID:11672593   PMID:11986301   PMID:12091878   PMID:12443841   PMID:12594207   PMID:12719478   PMID:15220916  
PMID:15294986   PMID:15356140   PMID:15690042   PMID:16177377   PMID:16489656   PMID:16601243   PMID:16879708   PMID:16880211   PMID:16949315   PMID:16954392   PMID:17027917   PMID:17053043  
PMID:17114491   PMID:17128265   PMID:17417665   PMID:17460566   PMID:17600044   PMID:17889651   PMID:17971865   PMID:18204298   PMID:18261938   PMID:18319620   PMID:18592153   PMID:19047410  
PMID:19115402   PMID:19139201   PMID:19326394   PMID:19454685   PMID:19509287   PMID:19527807   PMID:19740627   PMID:19770268   PMID:19861264   PMID:19930876   PMID:19931471   PMID:20020500  
PMID:20023008   PMID:20113783   PMID:20421349   PMID:20441518   PMID:20534434   PMID:20628242   PMID:20665543   PMID:20717659   PMID:20945380   PMID:21109260   PMID:21343866   PMID:21618349  
PMID:21870333   PMID:21875662   PMID:22033934   PMID:22067617   PMID:22099754   PMID:22198949   PMID:22242189   PMID:22402367   PMID:22523073   PMID:23155421   PMID:23447644   PMID:23656243  
PMID:23817958   PMID:23826189   PMID:24082081   PMID:24091496   PMID:24423688   PMID:24660535   PMID:24846408   PMID:24871424   PMID:24966901   PMID:25224460   PMID:25465639   PMID:25530127  
PMID:25534427   PMID:25780291   PMID:25800037   PMID:25931256   PMID:25990971   PMID:26436391   PMID:26475712   PMID:26477714   PMID:26649771   PMID:26744383   PMID:26898123   PMID:26962463  
PMID:27107801   PMID:27108485   PMID:27312383   PMID:27391866   PMID:28078022   PMID:28243080   PMID:28257481   PMID:28293064   PMID:28432060   PMID:28822965   PMID:28889066   PMID:29536648  
PMID:30031930   PMID:30107238   PMID:30222725   PMID:30480410   PMID:31002842   PMID:31678237   PMID:32377693   PMID:32384574   PMID:32634389   PMID:32879625   PMID:33652137   PMID:34015428  
PMID:35322444   PMID:36972303  


Genomics

Comparative Map Data
Tlr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82171,499,189 - 171,504,831 (-)NCBIGRCr8
mRatBN7.22169,200,620 - 169,206,819 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2169,197,419 - 169,206,630 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2176,379,970 - 176,385,353 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02174,399,903 - 174,405,286 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02169,001,363 - 169,006,752 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02182,840,171 - 182,846,061 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2182,840,727 - 182,846,061 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02202,252,701 - 202,258,962 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42175,607,990 - 175,613,992 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12175,558,096 - 175,564,098 (-)NCBI
Celera2163,202,040 - 163,207,399 (-)NCBICelera
Cytogenetic Map2q34NCBI
TLR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384153,684,280 - 153,710,637 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4153,684,070 - 153,706,260 (+)EnsemblGRCh38hg38GRCh38
GRCh374154,605,432 - 154,627,412 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364154,824,891 - 154,846,693 (+)NCBINCBI36Build 36hg18NCBI36
Build 344154,966,670 - 154,984,135NCBI
Celera4151,929,928 - 151,951,730 (+)NCBICelera
Cytogenetic Map4q31.3NCBI
HuRef4150,336,457 - 150,358,268 (+)NCBIHuRef
CHM1_14154,583,811 - 154,605,614 (+)NCBICHM1_1
T2T-CHM13v2.04157,008,777 - 157,030,716 (+)NCBIT2T-CHM13v2.0
Tlr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39383,743,579 - 83,749,045 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl383,743,579 - 83,749,074 (-)EnsemblGRCm39 Ensembl
GRCm38383,836,272 - 83,841,824 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl383,836,272 - 83,841,767 (-)EnsemblGRCm38mm10GRCm38
MGSCv37383,640,194 - 83,645,530 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36383,922,199 - 83,927,694 (-)NCBIMGSCv36mm8
Celera383,852,064 - 83,857,400 (-)NCBICelera
Cytogenetic Map3E3NCBI
cM Map337.4NCBI
Tlr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554718,014,910 - 8,017,258 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554718,011,710 - 8,019,063 (+)NCBIChiLan1.0ChiLan1.0
TLR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23151,528,318 - 151,594,177 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14151,924,943 - 151,949,250 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04146,024,653 - 146,091,388 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14157,848,058 - 157,870,324 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4157,866,977 - 157,869,331 (+)Ensemblpanpan1.1panPan2
TLR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11551,454,557 - 51,465,429 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1551,454,695 - 51,465,241 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1551,808,717 - 51,811,083 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01552,140,775 - 52,151,566 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11551,404,786 - 51,407,152 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01551,510,608 - 51,512,974 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01551,821,784 - 51,824,151 (+)NCBIUU_Cfam_GSD_1.0
Tlr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530139,016,995 - 39,024,812 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936576527,434 - 529,788 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936576522,234 - 531,660 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TLR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl875,411,993 - 75,428,330 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1875,416,257 - 75,428,370 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2879,823,867 - 79,834,881 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TLR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17100,239,533 - 100,565,955 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7100,258,441 - 100,260,795 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603779,891,761 - 79,956,832 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tlr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248584,979,485 - 4,981,833 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248584,931,820 - 4,984,175 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tlr2
49 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:121
Count of miRNA genes:103
Interacting mature miRNAs:108
Transcripts:ENSRNOT00000013025
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527185876470Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
6907363Bp357Blood pressure QTL 3574.10.002arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2129540907174540907Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2143657411190602963Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2143657411190602963Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2143657569184114274Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2144599348189599348Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147798556192798556Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150341585189039377Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
12879845Cm89Cardiac mass QTL 890.008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072175950118Rat
12879846Cm90Cardiac mass QTL 900.011heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)2152413072175950118Rat
12879847Am4Aortic mass QTL 40.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072175950118Rat
11565180Kidm56Kidney mass QTL 560.003kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072175950118Rat
11565181Bw176Body weight QTL 1760.002body mass (VT:0001259)body weight (CMO:0000012)2152413072175950118Rat
2301415Cm67Cardiac mass QTL 670.003heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072175950118Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072185122374Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072185122374Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072185122374Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072185122374Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2152413072185122374Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2157142078192625452Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168354880185122374Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat

Markers in Region
RH144365  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22169,201,531 - 169,201,724 (+)MAPPERmRatBN7.2
Rnor_6.02182,841,083 - 182,841,275NCBIRnor6.0
Rnor_5.02202,253,613 - 202,253,805UniSTSRnor5.0
RGSC_v3.42175,608,347 - 175,608,539UniSTSRGSC3.4
Celera2163,202,397 - 163,202,589UniSTS
RH 3.4 Map21105.2UniSTS
Cytogenetic Map2q34UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 8 19 3 5
Low 3 43 45 37 37 8 10 74 35 34 6 8
Below cutoff 4 4 4 1 3

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_198769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AY151255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY151256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF127847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF127848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730131 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730134 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730136 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730137 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730138 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730141 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730146 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730148 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730155 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730173 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730176 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730178 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730179 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730189 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730193 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730194 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730196 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730206 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730207 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730209 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730212 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730215 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730218 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730219 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730223 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730225 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730227 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730230 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730233 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730234 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730235 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730236 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730237 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730238 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730239 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730240 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000013025   ⟹   ENSRNOP00000013025
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2169,198,149 - 169,206,630 (-)Ensembl
Rnor_6.0 Ensembl2182,840,727 - 182,846,061 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000097289   ⟹   ENSRNOP00000095767
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2169,197,419 - 169,206,630 (-)Ensembl
RefSeq Acc Id: NM_198769   ⟹   NP_942064
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82171,499,189 - 171,504,557 (-)NCBI
mRatBN7.22169,201,175 - 169,206,545 (-)NCBI
Rnor_6.02182,840,726 - 182,846,061 (-)NCBI
Rnor_5.02202,252,701 - 202,258,962 (-)NCBI
RGSC_v3.42175,607,990 - 175,613,992 (-)RGD
Celera2163,202,040 - 163,207,399 (-)RGD
Sequence:
RefSeq Acc Id: XM_008761102   ⟹   XP_008759324
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82171,499,189 - 171,504,831 (-)NCBI
mRatBN7.22169,200,620 - 169,206,819 (-)NCBI
Rnor_6.02182,840,171 - 182,846,006 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_942064 (Get FASTA)   NCBI Sequence Viewer  
  XP_008759324 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAN86524 (Get FASTA)   NCBI Sequence Viewer  
  AAN86525 (Get FASTA)   NCBI Sequence Viewer  
  ABL75415 (Get FASTA)   NCBI Sequence Viewer  
  ABL75416 (Get FASTA)   NCBI Sequence Viewer  
  EDM00832 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000013025.3
  ENSRNOP00000095767
  ENSRNOP00000095767.1
GenBank Protein QQJ42660 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42661 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42662 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42663 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42664 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42665 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42666 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42667 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42668 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42669 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42670 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42671 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42672 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42673 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42674 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42675 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42676 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42677 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42678 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42679 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42680 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42681 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42682 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42683 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42684 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42685 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42686 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42687 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42688 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42689 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42690 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42691 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42692 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42693 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42694 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42695 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42696 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42697 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42698 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42699 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42700 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42701 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42702 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42703 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42704 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42705 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42706 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42707 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42708 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42709 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42710 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42711 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42712 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42713 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42714 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42715 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42716 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42717 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42718 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42719 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42720 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42721 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42722 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42723 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42724 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42725 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42726 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42727 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42728 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42729 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42730 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42731 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42732 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42733 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42734 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42735 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42736 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42737 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42738 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42739 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42740 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42741 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42742 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42743 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42744 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42745 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42746 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42747 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42748 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42749 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42750 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42751 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42752 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42753 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42754 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42755 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42756 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42757 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42758 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42759 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42760 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42761 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42762 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42763 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42764 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42765 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42766 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42767 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42768 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42769 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42770 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42771 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42772 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42773 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_942064   ⟸   NM_198769
- Peptide Label: precursor
- UniProtKB: Q6YGU2 (UniProtKB/TrEMBL),   A6J5V7 (UniProtKB/TrEMBL),   E9PTD9 (UniProtKB/TrEMBL),   A0A8K0ZGH5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008759324   ⟸   XM_008761102
- Peptide Label: isoform X1
- UniProtKB: E9PTD9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000013025   ⟸   ENSRNOT00000013025
RefSeq Acc Id: ENSRNOP00000095767   ⟸   ENSRNOT00000097289
Protein Domains
TIR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-E9PTD9-F1-model_v2 AlphaFold E9PTD9 1-784 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691399
Promoter ID:EPDNEW_R1924
Type:initiation region
Name:Tlr2_1
Description:toll-like receptor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02182,846,087 - 182,846,147EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:735138 AgrOrtholog
BioCyc Gene G2FUF-52648 BioCyc
Ensembl Genes ENSRNOG00000009822 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000013025.5 UniProtKB/TrEMBL
  ENSRNOT00000097289 ENTREZGENE
  ENSRNOT00000097289.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.10140 UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/TrEMBL
InterPro Cys-rich_flank_reg_C UniProtKB/TrEMBL
  L_dom-like UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/TrEMBL
  Toll-Interleukin_rcpt UniProtKB/TrEMBL
  Toll-like_receptor UniProtKB/TrEMBL
  Toll_tir_struct_dom_sf UniProtKB/TrEMBL
KEGG Report rno:310553 UniProtKB/TrEMBL
NCBI Gene 310553 ENTREZGENE
PANTHER PTHR24365 UniProtKB/TrEMBL
  PTHR24365:SF17 UniProtKB/TrEMBL
Pfam LRR_8 UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
PhenoGen Tlr2 PhenoGen
PIRSF Toll-like_receptor UniProtKB/TrEMBL
PRINTS INTRLKN1R1F UniProtKB/TrEMBL
  LEURICHRPT UniProtKB/TrEMBL
PROSITE LRR UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009822 RatGTEx
SMART LRR_BAC UniProtKB/TrEMBL
  LRR_TYP UniProtKB/TrEMBL
  LRRCT UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/TrEMBL
  RNI-like UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
UniProt A0A8K0ZGH5 ENTREZGENE, UniProtKB/TrEMBL
  A6J5V7 ENTREZGENE
  E9PTD9 ENTREZGENE, UniProtKB/TrEMBL
  Q6YGU2 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A6J5V7 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Tlr2  toll-like receptor 2    toll-like receptor 2 variant 1  Name updated 1299863 APPROVED