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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2200 Species: Rattus norvegicus RGD Object: Gene Symbol: Bcl2l1 Name: Bcl2-like 1

Acc ID: CHEBI:9352 Term: sulindac Definition: A sulfoxide that has formula C20H17FO3S. CasRN: 38194-50-2 Chemical ID: MESH:D013467

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:735516	6480464	CTD	Acetylcysteine inhibits the reaction [[Sulindac co-treated with arsenic trioxide] results in increased phosphorylation of BCL2L1 protein] anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [[Sulindac co-treated with arsenic trioxide] results in increased phosphorylation of BCL2L1 protein] MAPK8 affects the reaction [[Sulindac co-treated with arsenic trioxide] results in increased phosphorylation of BCL2L1 protein]	PMID:18281123
decreases expression	ISO	RGD:735516	6480464	CTD	Sulindac results in decreased expression of BCL2L1 protein	PMID:11062132