Mark3 (microtubule affinity regulating kinase 3) - Rat Genome Database

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Gene: Mark3 (microtubule affinity regulating kinase 3) Rattus norvegicus
Analyze
Symbol: Mark3
Name: microtubule affinity regulating kinase 3
RGD ID: 619883
Description: Predicted to enable protein serine/threonine kinase activity and tau-protein kinase activity. Predicted to be involved in intracellular signal transduction; negative regulation of hippo signaling; and negative regulation of protein localization to nucleus. Predicted to be located in dendrite. Predicted to be active in cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in visual impairment and progressive phthisis bulbi. Orthologous to human MARK3 (microtubule affinity regulating kinase 3); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MAP/microtubule affinity-regulating kinase 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86136,447,327 - 136,537,409 (+)NCBIGRCr8
mRatBN7.26130,626,612 - 130,716,245 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6130,627,482 - 130,716,647 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6130,794,704 - 130,882,984 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06131,090,690 - 131,178,967 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06130,457,578 - 130,545,967 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06136,040,957 - 136,129,780 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6136,041,777 - 136,129,661 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06144,286,952 - 144,375,010 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46136,348,832 - 136,438,667 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16136,355,018 - 136,444,854 (+)NCBI
Celera6128,183,127 - 128,271,232 (+)NCBICelera
Cytogenetic Map6q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cell projection  (IEA)
cytoplasm  (IBA,IEA,ISO,ISS)
dendrite  (IEA,ISO,ISS)
plasma membrane  (IBA,IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
3. C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding. Peng CY, etal., Cell Growth Differ. 1998 Mar;9(3):197-208.
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Information Derived from GenBank Report RGD, Sept. 2003
Additional References at PubMed
PMID:16980613   PMID:18570454   PMID:21145462   PMID:23666762   PMID:25931508   PMID:28087714  


Genomics

Comparative Map Data
Mark3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86136,447,327 - 136,537,409 (+)NCBIGRCr8
mRatBN7.26130,626,612 - 130,716,245 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6130,627,482 - 130,716,647 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6130,794,704 - 130,882,984 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06131,090,690 - 131,178,967 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06130,457,578 - 130,545,967 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06136,040,957 - 136,129,780 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6136,041,777 - 136,129,661 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06144,286,952 - 144,375,010 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46136,348,832 - 136,438,667 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16136,355,018 - 136,444,854 (+)NCBI
Celera6128,183,127 - 128,271,232 (+)NCBICelera
Cytogenetic Map6q32NCBI
MARK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814103,385,415 - 103,503,831 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14103,385,377 - 103,503,831 (+)EnsemblGRCh38hg38GRCh38
GRCh3714103,851,752 - 103,970,168 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3614102,921,524 - 103,039,921 (+)NCBINCBI36Build 36hg18NCBI36
Build 3414102,921,523 - 103,039,917NCBI
Celera1483,905,890 - 84,024,379 (+)NCBICelera
Cytogenetic Map14q32.32-q32.33NCBI
HuRef1484,029,889 - 84,148,541 (+)NCBIHuRef
CHM1_114103,789,889 - 103,908,361 (+)NCBICHM1_1
T2T-CHM13v2.01497,621,350 - 97,739,863 (+)NCBIT2T-CHM13v2.0
Mark3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912111,540,929 - 111,622,661 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12111,540,957 - 111,622,655 (+)EnsemblGRCm39 Ensembl
GRCm3812111,574,505 - 111,656,227 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12111,574,523 - 111,656,221 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712112,812,721 - 112,894,438 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612112,022,777 - 112,104,031 (+)NCBIMGSCv36mm8
Celera12112,768,826 - 112,852,637 (+)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1261.05NCBI
Mark3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555382,273,221 - 2,371,154 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555382,273,221 - 2,370,204 (+)NCBIChiLan1.0ChiLan1.0
MARK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v215104,544,746 - 104,663,152 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan114103,761,598 - 103,879,656 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01484,012,076 - 84,130,136 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.114103,823,900 - 103,941,529 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl14103,823,900 - 103,941,529 (+)Ensemblpanpan1.1panPan2
MARK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1871,148,263 - 71,269,717 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl871,102,690 - 71,270,399 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha870,659,869 - 70,780,993 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0871,424,060 - 71,545,499 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl871,424,234 - 71,545,424 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1871,113,816 - 71,234,630 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0871,153,195 - 71,274,345 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0871,552,492 - 71,673,590 (+)NCBIUU_Cfam_GSD_1.0
Mark3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086402,798,889 - 2,904,084 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366211,627,431 - 1,733,047 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366211,627,846 - 1,733,041 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MARK3
(Sus scrofa - pig)		 No map positions available.
MARK3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12481,364,316 - 81,452,115 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2481,364,361 - 81,455,070 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605368,632,588 - 68,747,799 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mark3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247341,362,263 - 1,469,930 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mark3
264 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:33
Count of miRNA genes:32
Interacting mature miRNAs:33
Transcripts:ENSRNOT00000014395
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
1300076Glom8Glomerulus QTL 870.000000009kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6100671796132340886Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6105156861140994061Rat
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6106752656132339866Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6112636280140994061Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)6122549046137801795Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6122549046140286318Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)6122549046140994061Rat
2312560Pur20Proteinuria QTL 202.10.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)6125628133137801795Rat

Markers in Region
BE120426  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26130,706,394 - 130,706,552 (+)MAPPERmRatBN7.2
Rnor_6.06136,119,992 - 136,120,149NCBIRnor6.0
Rnor_5.06144,296,583 - 144,296,740UniSTSRnor5.0
RGSC_v3.46136,429,586 - 136,429,743UniSTSRGSC3.4
Celera6128,261,857 - 128,262,014UniSTS
RH 3.4 Map6780.11UniSTS
Cytogenetic Map6q32UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_130749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111718 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111720 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111725 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261495 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261496 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261497 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261498 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261499 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF465412 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235189 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000014395   ⟹   ENSRNOP00000014395
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6130,636,043 - 130,715,874 (+)Ensembl
Rnor_6.0 Ensembl6136,041,777 - 136,129,409 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000080304   ⟹   ENSRNOP00000068972
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6130,627,482 - 130,716,115 (+)Ensembl
Rnor_6.0 Ensembl6136,050,422 - 136,129,661 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000088784   ⟹   ENSRNOP00000073297
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6130,627,482 - 130,715,874 (+)Ensembl
Rnor_6.0 Ensembl6136,042,059 - 136,129,409 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000092806   ⟹   ENSRNOP00000075961
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6130,644,820 - 130,715,874 (+)Ensembl
Rnor_6.0 Ensembl6136,084,605 - 136,129,631 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000094828   ⟹   ENSRNOP00000091306
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6130,627,482 - 130,716,647 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000105097   ⟹   ENSRNOP00000082974
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6130,645,056 - 130,716,647 (+)Ensembl
RefSeq Acc Id: NM_130749   ⟹   NP_570105
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86136,448,651 - 136,537,038 (+)NCBI
mRatBN7.26130,627,482 - 130,715,874 (+)NCBI
Rnor_6.06136,042,059 - 136,129,409 (+)NCBI
Rnor_5.06144,286,952 - 144,375,010 (-)NCBI
RGSC_v3.46136,348,832 - 136,438,667 (+)RGD
Celera6128,183,127 - 128,271,232 (+)RGD
Sequence:
RefSeq Acc Id: XM_006240563   ⟹   XP_006240625
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86136,448,193 - 136,537,409 (+)NCBI
mRatBN7.26130,627,035 - 130,716,245 (+)NCBI
Rnor_6.06136,041,926 - 136,129,780 (+)NCBI
Rnor_5.06144,286,952 - 144,375,010 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017594010   ⟹   XP_017449499
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86136,466,266 - 136,537,409 (+)NCBI
mRatBN7.26130,627,030 - 130,716,245 (+)NCBI
Rnor_6.06136,040,957 - 136,129,780 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594011   ⟹   XP_017449500
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86136,466,266 - 136,537,409 (+)NCBI
mRatBN7.26130,627,031 - 130,716,245 (+)NCBI
Rnor_6.06136,040,957 - 136,129,780 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039111715   ⟹   XP_038967643
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86136,466,266 - 136,537,409 (+)NCBI
mRatBN7.26130,645,098 - 130,716,245 (+)NCBI
RefSeq Acc Id: XM_039111717   ⟹   XP_038967645
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86136,466,266 - 136,537,409 (+)NCBI
mRatBN7.26130,645,098 - 130,716,245 (+)NCBI
RefSeq Acc Id: XM_039111718   ⟹   XP_038967646
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86136,455,789 - 136,537,409 (+)NCBI
mRatBN7.26130,634,574 - 130,716,245 (+)NCBI
RefSeq Acc Id: XM_039111720   ⟹   XP_038967648
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86136,466,266 - 136,537,409 (+)NCBI
mRatBN7.26130,645,098 - 130,716,245 (+)NCBI
RefSeq Acc Id: XM_039111721   ⟹   XP_038967649
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86136,448,193 - 136,537,409 (+)NCBI
mRatBN7.26130,627,035 - 130,716,245 (+)NCBI
RefSeq Acc Id: XM_039111723   ⟹   XP_038967651
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86136,447,327 - 136,509,851 (+)NCBI
mRatBN7.26130,626,612 - 130,688,688 (+)NCBI
RefSeq Acc Id: XM_039111724   ⟹   XP_038967652
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86136,503,818 - 136,537,409 (+)NCBI
mRatBN7.26130,671,150 - 130,716,245 (+)NCBI
RefSeq Acc Id: XM_039111725   ⟹   XP_038967653
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86136,503,818 - 136,537,409 (+)NCBI
mRatBN7.26130,671,150 - 130,716,245 (+)NCBI
RefSeq Acc Id: XM_063261495   ⟹   XP_063117565
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86136,448,163 - 136,537,409 (+)NCBI
RefSeq Acc Id: XM_063261496   ⟹   XP_063117566
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86136,448,177 - 136,537,409 (+)NCBI
RefSeq Acc Id: XM_063261497   ⟹   XP_063117567
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86136,448,193 - 136,537,409 (+)NCBI
RefSeq Acc Id: XM_063261498   ⟹   XP_063117568
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86136,448,193 - 136,537,409 (+)NCBI
RefSeq Acc Id: XM_063261499   ⟹   XP_063117569
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86136,455,845 - 136,537,409 (+)NCBI
RefSeq Acc Id: XM_063261500   ⟹   XP_063117570
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86136,448,193 - 136,537,409 (+)NCBI
RefSeq Acc Id: XM_063261501   ⟹   XP_063117571
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86136,452,173 - 136,537,409 (+)NCBI
RefSeq Acc Id: XM_063261502   ⟹   XP_063117572
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86136,448,193 - 136,537,409 (+)NCBI
RefSeq Acc Id: XM_063261503   ⟹   XP_063117573
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86136,448,193 - 136,537,409 (+)NCBI
Protein Sequences
Protein RefSeqs NP_570105 (Get FASTA)   NCBI Sequence Viewer  
  XP_006240625 (Get FASTA)   NCBI Sequence Viewer  
  XP_017449499 (Get FASTA)   NCBI Sequence Viewer  
  XP_017449500 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967643 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967645 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967646 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967648 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967649 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967651 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967652 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967653 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117565 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117566 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117567 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117568 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117569 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117570 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117571 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117572 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117573 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAL69981 (Get FASTA)   NCBI Sequence Viewer  
  EDL97458 (Get FASTA)   NCBI Sequence Viewer  
  EDL97459 (Get FASTA)   NCBI Sequence Viewer  
  EDL97460 (Get FASTA)   NCBI Sequence Viewer  
  EDL97461 (Get FASTA)   NCBI Sequence Viewer  
  EDL97462 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000014395
  ENSRNOP00000014395.4
  ENSRNOP00000068972
  ENSRNOP00000068972.2
  ENSRNOP00000073297
  ENSRNOP00000073297.1
  ENSRNOP00000075961.2
  ENSRNOP00000082974.1
  ENSRNOP00000091306.1
GenBank Protein Q8VHF0 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_570105   ⟸   NM_130749
- UniProtKB: Q8VHF0 (UniProtKB/Swiss-Prot),   A0A0G2K554 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240625   ⟸   XM_006240563
- Peptide Label: isoform X6
- UniProtKB: A0A0G2K554 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017449500   ⟸   XM_017594011
- Peptide Label: isoform X2
- UniProtKB: A6KBR9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017449499   ⟸   XM_017594010
- Peptide Label: isoform X1
- UniProtKB: A6KBR9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000068972   ⟸   ENSRNOT00000080304
RefSeq Acc Id: ENSRNOP00000075961   ⟸   ENSRNOT00000092806
RefSeq Acc Id: ENSRNOP00000014395   ⟸   ENSRNOT00000014395
RefSeq Acc Id: ENSRNOP00000073297   ⟸   ENSRNOT00000088784
RefSeq Acc Id: XP_038967651   ⟸   XM_039111723
- Peptide Label: isoform X18
RefSeq Acc Id: XP_038967649   ⟸   XM_039111721
- Peptide Label: isoform X12
- UniProtKB: A0A0G2K554 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038967646   ⟸   XM_039111718
- Peptide Label: isoform X7
- UniProtKB: F1M836 (UniProtKB/TrEMBL),   A0A0G2K554 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038967643   ⟸   XM_039111715
- Peptide Label: isoform X4
- UniProtKB: A0A0G2JU56 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038967645   ⟸   XM_039111717
- Peptide Label: isoform X5
- UniProtKB: A0A0G2JU56 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038967648   ⟸   XM_039111720
- Peptide Label: isoform X9
RefSeq Acc Id: XP_038967652   ⟸   XM_039111724
- Peptide Label: isoform X19
RefSeq Acc Id: XP_038967653   ⟸   XM_039111725
- Peptide Label: isoform X20
RefSeq Acc Id: ENSRNOP00000091306   ⟸   ENSRNOT00000094828
RefSeq Acc Id: ENSRNOP00000082974   ⟸   ENSRNOT00000105097
RefSeq Acc Id: XP_063117565   ⟸   XM_063261495
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063117566   ⟸   XM_063261496
- Peptide Label: isoform X8
RefSeq Acc Id: XP_063117567   ⟸   XM_063261497
- Peptide Label: isoform X10
RefSeq Acc Id: XP_063117568   ⟸   XM_063261498
- Peptide Label: isoform X11
RefSeq Acc Id: XP_063117570   ⟸   XM_063261500
- Peptide Label: isoform X14
RefSeq Acc Id: XP_063117572   ⟸   XM_063261502
- Peptide Label: isoform X16
RefSeq Acc Id: XP_063117573   ⟸   XM_063261503
- Peptide Label: isoform X17
RefSeq Acc Id: XP_063117571   ⟸   XM_063261501
- Peptide Label: isoform X15
RefSeq Acc Id: XP_063117569   ⟸   XM_063261499
- Peptide Label: isoform X13
Protein Domains
KA1   Protein kinase   UBA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8VHF0-F1-model_v2 AlphaFold Q8VHF0 1-797 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619883 AgrOrtholog
BioCyc Gene G2FUF-35837 BioCyc
Ensembl Genes ENSRNOG00000010330 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000014395.5 UniProtKB/TrEMBL
  ENSRNOT00000080304.2 UniProtKB/TrEMBL
  ENSRNOT00000088784 ENTREZGENE
  ENSRNOT00000088784.3 UniProtKB/TrEMBL
  ENSRNOT00000092806.2 UniProtKB/TrEMBL
  ENSRNOT00000094828.1 UniProtKB/TrEMBL
  ENSRNOT00000105097.1 UniProtKB/TrEMBL
Gene3D-CATH DNA helicase RuvA subunit, C-terminal domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase associated domain 1, KA1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro KA1/Ssp2_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KA1_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MARK1-4_cat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:170577 UniProtKB/Swiss-Prot
NCBI Gene 170577 ENTREZGENE
PANTHER MAP/MICROTUBULE AFFINITY-REGULATING KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24346:SF1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERINE_THREONINE-PROTEIN KINASE MARK2 UniProtKB/TrEMBL
Pfam KA1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mark3 PhenoGen
PROSITE KA1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010330 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF103243 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JU56 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K554 ENTREZGENE, UniProtKB/TrEMBL
  A0A1B0GWN5_RAT UniProtKB/TrEMBL
  A0A8I5ZV33_RAT UniProtKB/TrEMBL
  A0A8I6GIW6_RAT UniProtKB/TrEMBL
  A6KBR9 ENTREZGENE, UniProtKB/TrEMBL
  A6KBS0_RAT UniProtKB/TrEMBL
  A6KBS3_RAT UniProtKB/TrEMBL
  F1M836 ENTREZGENE, UniProtKB/TrEMBL
  MARK3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Mark3  microtubule affinity regulating kinase 3  Mark3  MAP/microtubule affinity-regulating kinase 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Mark3  MAP/microtubule affinity-regulating kinase 3      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Mark3  MAP/microtubule affinity-regulating kinase 3      Symbol and Name status set to provisional 70820 PROVISIONAL