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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2543
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Egfr
Name: epidermal growth factor receptor
Acc ID: CHEBI:64212
Term: sulindac sulfone
Definition: A sulfone metabolite of sulindac that inhibits cell growth by inducing apoptosis independently of cyclooxygenase inhibition. It inhibits the development and induces regression of premalignant adenomatous polyps. Lipoxygenase and Cox-2 inhibitor.
Chemical ID: MESH:C025463
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Egfrmultiple interactionsEXP 6480464CTD[Celecoxib co-treated with sulindac sulfone] results in decreased expression of EGFR protein; [Celecoxib co-treated with sulindac sulfone] results in decreased expression of EGFR protein modified formPMID:17908994
Egfrdecreases expressionISOEGFR (Homo sapiens)6480464CTDsulindac sulfone results in decreased expression of EGFR proteinPMID:20332299
Egfrdecreases phosphorylationISOEGFR (Homo sapiens)6480464CTDsulindac sulfone results in decreased phosphorylation of EGFR proteinPMID:20332299
Egfrincreases phosphorylationISOEGFR (Homo sapiens)6480464CTDsulindac sulfone results in increased phosphorylation of EGFR proteinPMID:20332299
Egfrincreases ubiquitinationISOEGFR (Homo sapiens)6480464CTDsulindac sulfone results in increased ubiquitination of EGFR proteinPMID:20332299
Egfrmultiple interactionsISOEGFR (Homo sapiens)6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sulindac sulfone results in decreased expression of EGFR protein]; Chloroquine inhibits the reaction [sulindac sulfone results in decreased expression of EGFR protein]PMID:20332299
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