Akr1b1 (aldo-keto reductase family 1, member B1 (aldose reductase))

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Keyword

Gene: Akr1b1 (aldo-keto reductase family 1, member B1 (aldose reductase)) Rattus norvegicus

Symbol:

Akr1b1

Name:

aldo-keto reductase family 1, member B1 (aldose reductase)

Description:

ENCODES a protein that exhibits alditol:NADP+ 1-oxidoreductase activity; glyceraldehyde oxidoreductase activity (ortholog); INVOLVED IN positive regulation of JAK-STAT cascade; positive regulation of smooth muscle cell proliferation; response to organic substance; PARTICIPATES IN altered galactose metabolic pathway; diabetic nephropathy pathway; fructose and mannose metabolic pathway; ASSOCIATED WITH Arteriosclerosis; Cataract; Diabetic Neuropathies; FOUND IN extracellular space; cytoplasm (ortholog); nucleus (ortholog); INTERACTS WITH (+)-alpha-tocopherol; 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

Akr1b3; Akr1b4; Aldehyde reductase 1 (low Km aldose reductase) (5.8 kb PstI fragment, probably the functional gene); aldo-keto reductase family 1 member B1; aldo-keto reductase family 1 member B1 (aldose reductase); aldo-keto reductase family 1, member B4 (aldose reductase); aldose reductase; Aldr1; ALDRED; Alr; ALR-P-I; AR; RATALDRED

Orthologs:

Homo sapiens : AKR1B1 (aldo-keto reductase family 1, member B1 (aldose reductase)) HGNC
Mus musculus : Akr1b3 (aldo-keto reductase family 1, member B3 (aldose reductase)) MGI

Related Pseudogenes:

Akr1b1-ps1 Akr1b1-ps2 Akr1b1-ps3

Latest Assembly:

RGSC Genome Assembly v3.4

Position:

Map	Chr	Position	Strand	Source
Rat Cytogenetic Map	4	q22		NCBI
RGSC Genome Assembly v5.0	4	61,426,190 - 61,440,279	-	NCBI
RGSC Genome Assembly v3.4	4	61,645,438 - 61,659,530	-	NCBI
Rat Celera Assembly	4	57,984,561 - 57,998,653	-	NCBI
Genome Assembly 3.1	4	61,921,567 - 61,935,660	-	NCBI
RH 3.4	4	393.32		RGD