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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Transplant Rejection
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Accession:DOID:9004283 term browser browse the term
Definition:A process in which a transplant recipient's immune system attacks the transplanted organ or tissue. The rejection can be hyperacute (occurring within a few minutes), acute (occurring within days to months), or chronic (occurring over many years).


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Transplant Rejection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr2b activin receptor IIB treatment ISO human construct in rat model RGD PMID:27732750 RGD:329322881 NCBI chr 9:119,231,081...119,271,214
Ensembl chr 9:119,231,184...119,264,061 		JBrowse link
G Apoa1 apolipoprotein A-I ISO protein:decreased expression:plasma RGD PMID:21730889 RGD:7241209 NCBI chr 9:46,139,928...46,141,767
Ensembl chr 9:46,139,878...46,141,764 		JBrowse link
G Arrb1 arrestin, beta 1 ISO mRNA:decreased expression:blood, leukocyte RGD PMID:21193245 RGD:13506894 NCBI chr 7:99,184,356...99,255,979
Ensembl chr 7:99,184,673...99,255,978 		JBrowse link
G Arrb2 arrestin, beta 2 ISO mRNA, protein:decreased expression:blood, leukocyte, monocyte RGD PMID:21193245 RGD:13506894 NCBI chr11:70,323,051...70,331,654
Ensembl chr11:70,323,461...70,331,654 		JBrowse link
G Bag6 BCL2-associated athanogene 6 susceptibility ISO DNA:haplotype: :rs10484558(human) RGD PMID:25111513 RGD:14390152 NCBI chr17:35,354,132...35,366,297
Ensembl chr17:35,354,154...35,366,298 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 susceptibility ISO
IMP		 kidney;DNA:snp:promoter:g.-2518A>G (human) RGD PMID:12239249 PMID:14662900 RGD:8548879, RGD:8657367 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 ISO RGD PMID:20688906 RGD:7241797 NCBI chr11:83,538,669...83,540,204
Ensembl chr11:83,538,670...83,540,181 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 IMP RGD PMID:14662900 RGD:8657367 NCBI chr 9:123,901,954...123,913,594
Ensembl chr 9:123,901,987...123,913,594 		JBrowse link
G Ccr5 C-C motif chemokine receptor 5 treatment ISO RGD PMID:23498802 PMID:23446583 RGD:8552228, RGD:8552231 NCBI chr 9:123,921,557...123,934,153
Ensembl chr 9:123,921,580...123,947,736 		JBrowse link
G Cd274 CD274 antigen IMP RGD PMID:14662900 RGD:8657367 NCBI chr19:29,339,428...29,365,495
Ensembl chr19:29,344,855...29,365,495 		JBrowse link
G Cd4 CD4 antigen treatment ISO
IMP		 RGD PMID:1704648 PMID:11081762 RGD:10058956, RGD:10058974 NCBI chr 6:124,841,656...124,865,210
Ensembl chr 6:124,841,655...124,865,184 		JBrowse link
G Cd40 CD40 antigen disease_progression
treatment		 ISO associated with Diabetes Mellitus, Experimental RGD PMID:15221125 PMID:14698004 PMID:21472009 RGD:7248441, RGD:8547788, RGD:7248755 NCBI chr 2:164,897,535...164,913,574
Ensembl chr 2:164,897,547...164,914,868 		JBrowse link
G Cd40lg CD40 ligand treatment ISO
IMP		 protein:increased expression:blood, T cell
associated with Diabetes Mellitus		 RGD PMID:22948742 PMID:15808676 PMID:10949194 PMID:15016184 RGD:7248420, RGD:8547783, RGD:7248719, RGD:7248598 NCBI chr  X:56,257,448...56,269,402
Ensembl chr  X:56,257,503...56,269,402 		JBrowse link
G Chrna3 cholinergic receptor, nicotinic, alpha polypeptide 3 ISO RGD PMID:25121092 RGD:151347544 NCBI chr 9:54,917,401...54,933,846
Ensembl chr 9:54,917,395...54,933,846 		JBrowse link
G Chrnb4 cholinergic receptor, nicotinic, beta polypeptide 4 ISO RGD PMID:25121092 RGD:151347544 NCBI chr 9:54,935,438...54,956,236
Ensembl chr 9:54,935,438...54,956,063 		JBrowse link
G Col1a2 collagen, type I, alpha 2 ISO mRNA:increased expression:kidney RGD PMID:20150539 RGD:7248773 NCBI chr 6:4,505,618...4,541,543
Ensembl chr 6:4,504,814...4,541,544 		JBrowse link
G Col3a1 collagen, type III, alpha 1 ISO mRNA:increased expression:kidney RGD PMID:20150539 RGD:7248773 NCBI chr 1:45,350,698...45,388,866
Ensembl chr 1:45,350,698...45,388,866 		JBrowse link
G Csf1 colony stimulating factor 1 (macrophage) ISO mRNA:increased expression:kidney RGD PMID:19196448 PMID:11981428 RGD:7257570, RGD:7257590 NCBI chr 3:107,648,364...107,668,048
Ensembl chr 3:107,648,364...107,667,785 		JBrowse link
G Csf1r colony stimulating factor 1 receptor ISO RGD PMID:24056626 RGD:151665812 NCBI chr18:61,238,644...61,264,211
Ensembl chr18:61,233,670...61,265,221 		JBrowse link
G Csf3 colony stimulating factor 3 (granulocyte) treatment ISO RGD PMID:18589159 RGD:11039422 NCBI chr11:98,591,287...98,594,457
Ensembl chr11:98,592,089...98,594,455 		JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 susceptibility IMP
ISO		 DNA:SNP: :rs231775, korean(human)
DNA:SNP: :rs733618, chinese(human)		 RGD PMID:12096784 PMID:20940051 PMID:22418270 PMID:18074399 PMID:14551031 RGD:7204515, RGD:7204678, RGD:7204671, RGD:7204518, RGD:7204516 NCBI chr 1:60,948,184...60,954,991
Ensembl chr 1:60,926,159...60,954,991 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 severity ISO RGD PMID:28245475 RGD:27095950 NCBI chr 5:92,494,497...92,496,748
Ensembl chr 5:92,494,497...92,496,748 		JBrowse link
G Cxcr1 C-X-C motif chemokine receptor 1 ISO DNA:SNP:promoter:g.-2668G>A (rs2671222) (human) RGD PMID:21452410 RGD:7257676 NCBI chr 1:74,228,862...74,233,867
Ensembl chr 1:74,230,944...74,233,790 		JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 ISO RGD PMID:15840022 PMID:22882432 RGD:7257683, RGD:7257690 NCBI chr 1:74,193,153...74,200,405
Ensembl chr 1:74,193,150...74,200,405 		JBrowse link
G Dhodh dihydroorotate dehydrogenase treatment ISO RGD PMID:8443191 RGD:11040447 NCBI chr 8:110,319,876...110,335,330
Ensembl chr 8:110,317,975...110,335,305 		JBrowse link
G Ece1 endothelin converting enzyme 1 ISO RGD PMID:10401760 RGD:7244165 NCBI chr 4:137,589,548...137,692,540
Ensembl chr 4:137,589,548...137,692,540 		JBrowse link
G Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 IMP RGD PMID:10656876 RGD:9685445 NCBI chr19:40,600,810...40,730,046
Ensembl chr19:40,600,810...40,730,046 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signalling 1 treatment ISO RGD PMID:31828147 RGD:35316072 NCBI chr11:106,285,474...106,378,701
Ensembl chr11:106,285,476...106,378,678 		JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit treatment ISO RGD PMID:27784285 RGD:126781722 NCBI chr 6:47,507,208...47,613,843
Ensembl chr 6:47,507,073...47,572,275 		JBrowse link
G Fasl Fas ligand ISO mRNA, protein:increased expression:liver RGD PMID:10357921 RGD:14700698 NCBI chr 1:161,608,260...161,616,064
Ensembl chr 1:161,608,258...161,616,064 		JBrowse link
G Fcgr3 Fc receptor, IgG, low affinity III treatment ISO RGD PMID:10762218 RGD:9588604 NCBI chr 1:170,878,738...170,893,477
Ensembl chr 1:170,878,743...170,892,504 		JBrowse link
G Foxp3 forkhead box P3 treatment ISO
IEP		 mRNA:increased expression:liver RGD PMID:17414718 PMID:21199671 PMID:28457422 RGD:38456005, RGD:38599144, RGD:38549577 NCBI chr  X:7,445,915...7,461,482
Ensembl chr  X:7,439,883...7,461,484 		JBrowse link
G Gfer growth factor, augmenter of liver regeneration ISO RGD PMID:22819311 RGD:9685732 NCBI chr17:24,912,164...24,915,065
Ensembl chr17:24,912,161...24,915,130 		JBrowse link
G Got2 glutamatic-oxaloacetic transaminase 2, mitochondrial treatment ISO RGD PMID:28596681 RGD:13504864 NCBI chr 8:96,590,761...96,615,029
Ensembl chr 8:96,590,762...96,615,175 		JBrowse link
G Gstt1 glutathione S-transferase, theta 1 ISO associated with Hemoglobinopathies;DNA:deletion:: (human) RGD PMID:20348973 RGD:10450792 NCBI chr10:75,619,647...75,634,418
Ensembl chr10:75,619,647...75,634,418 		JBrowse link
G H2-Ab1 histocompatibility 2, class II antigen A, beta 1 ISO RGD PMID:1547813 RGD:7421554 NCBI chr17:34,482,201...34,488,392
Ensembl chr17:34,476,663...34,488,393 		JBrowse link
G H2-M2 histocompatibility 2, M region locus 2 treatment ISO human peptide in rat model; HLA-B7 RGD PMID:9233694 RGD:7387273 NCBI chr17:37,791,742...37,794,445
Ensembl chr17:37,791,742...37,794,443 		JBrowse link
G H2-Q4 histocompatibility 2, Q region locus 4 treatment ISO human peptide in rat model; HLA-B7 RGD PMID:9233694 RGD:7387273 NCBI chr17:35,598,593...35,603,650
Ensembl chr17:35,598,593...35,604,266 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 ISO RGD PMID:23435265 RGD:7244382 NCBI chr11:46,630,644...46,670,405
Ensembl chr11:46,625,907...46,670,405 		JBrowse link
G Havcr2 hepatitis A virus cellular receptor 2 ISO mRNA:increased expression:Leukocytes, Mononuclear:
mRNA,protein:increased expression:lung:		 RGD PMID:22172823 PMID:24508263 RGD:7245954, RGD:9686116 NCBI chr11:46,345,758...46,372,082
Ensembl chr11:46,345,762...46,372,082 		JBrowse link
G Hspd1 heat shock protein 1 (chaperonin) ISO RGD PMID:23953577 RGD:12910541 NCBI chr 1:55,116,992...55,127,402
Ensembl chr 1:55,116,994...55,127,402 		JBrowse link
G Ifng interferon gamma IDA RGD PMID:22564629 RGD:7364833 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Ikbkb inhibitor of kappaB kinase beta treatment ISO mRNA:increased expression:kidney RGD PMID:19249479 PMID:20500684 RGD:7495769, RGD:4892204 NCBI chr 8:23,149,228...23,196,605
Ensembl chr 8:23,149,228...23,196,605 		JBrowse link
G Il10 interleukin 10 treatment IDA
ISO		 RGD PMID:22564629 PMID:17275523 PMID:23870834 RGD:7364833, RGD:11049523, RGD:7364994 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Il13 interleukin 13 treatment ISO mRNA:increased expression:liver RGD PMID:17902182 PMID:17532783 PMID:17331844 RGD:8549629, RGD:10402939, RGD:8549647 NCBI chr11:53,522,150...53,525,529
Ensembl chr11:53,522,151...53,525,529 		JBrowse link
G Il15 interleukin 15 ISO mRNA:increased expression:liver RGD PMID:17532783 RGD:10402939 NCBI chr 8:83,058,253...83,129,883
Ensembl chr 8:83,058,261...83,129,851 		JBrowse link
G Il17a interleukin 17A treatment IMP
ISO		 protein:increased expression:liver, serum (rat) RGD PMID:20651239 PMID:23429965 PMID:21043049 RGD:9068426, RGD:9068938, RGD:4781440 NCBI chr 1:20,801,129...20,804,720
Ensembl chr 1:20,801,129...20,804,720 		JBrowse link
G Il18 interleukin 18 ISO RGD PMID:21962809 RGD:8655943 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140 		JBrowse link
G Il18bp interleukin 18 binding protein ISO RGD PMID:21962809 RGD:8655943 NCBI chr 7:101,664,281...101,669,699
Ensembl chr 7:101,664,092...101,667,897 		JBrowse link
G Il1b interleukin 1 beta severity ISO DNA:snp:intron:g.3962C>T (human) RGD PMID:22663993 PMID:8094579 RGD:7175098, RGD:7401188 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il1rn interleukin 1 receptor antagonist treatment ISO cornea transplant; human protein in a mouse model RGD PMID:9175817 RGD:8549799 NCBI chr 2:24,226,872...24,241,503
Ensembl chr 2:24,226,865...24,241,506 		JBrowse link
G Il2 interleukin 2 treatment IDA
IMP
ISO		 RGD PMID:22564629 PMID:18089405 PMID:3291556 RGD:7364833, RGD:10047078, RGD:8662936 NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108 		JBrowse link
G Il21 interleukin 21 ISO associated with hepatitis B;DNA:SNPs, haplotype:intron, CDS:1472G>T, 5250C>T (rs2055979, rs4833837) (human) RGD PMID:23656167 RGD:127285550 NCBI chr 3:37,276,908...37,286,785
Ensembl chr 3:37,276,908...37,286,785 		JBrowse link
G Il2rb interleukin 2 receptor, beta chain ameliorates IMP RGD PMID:9293878 RGD:42733040 NCBI chr15:78,363,456...78,396,569
Ensembl chr15:78,363,456...78,379,471 		JBrowse link
G Il5 interleukin 5 treatment ISO RGD PMID:11267027 RGD:11354977 NCBI chr11:53,611,621...53,615,930
Ensembl chr11:53,611,621...53,615,933 		JBrowse link
G Il7 interleukin 7 ISO mRNA:increased expression:liver RGD PMID:17532783 RGD:10402939 NCBI chr 3:7,637,088...7,678,820
Ensembl chr 3:7,635,054...7,678,820 		JBrowse link
G Itga4 integrin alpha 4 treatment IMP RGD PMID:9721793 RGD:9698437 NCBI chr 2:79,084,767...79,163,458
Ensembl chr 2:79,085,770...79,163,467 		JBrowse link
G Kdr kinase insert domain protein receptor IMP RGD PMID:22997228 RGD:8549738 NCBI chr 5:76,093,487...76,139,880
Ensembl chr 5:76,093,487...76,139,118 		JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase ISO mRNA:increased expression:liver: RGD PMID:9862859 RGD:12910749 NCBI chr 5:75,735,647...75,817,382
Ensembl chr 5:75,735,576...75,817,382 		JBrowse link
G Klrk1 killer cell lectin-like receptor subfamily K, member 1 ISO RGD PMID:20306467 RGD:9685184 NCBI chr 6:129,587,286...129,600,863
Ensembl chr 6:129,587,286...129,600,827 		JBrowse link
G Lta lymphotoxin A treatment ISO RGD PMID:8356596 PMID:2338821 RGD:8548835, RGD:8548836 NCBI chr17:35,422,141...35,424,568
Ensembl chr17:35,422,141...35,424,327 		JBrowse link
G Mmp3 matrix metallopeptidase 3 ISO RGD PMID:22845765 RGD:7241226 NCBI chr 9:7,445,845...7,455,975
Ensembl chr 9:7,445,822...7,455,975 		JBrowse link
G Muc2 mucin 2 ISO RGD PMID:12717211 RGD:7349372 NCBI chr 7:141,276,583...141,308,428
Ensembl chr 7:141,276,583...141,308,430 		JBrowse link
G Muc4 mucin 4 ISO RGD PMID:12717211 RGD:7349372 NCBI chr16:32,555,089...32,602,786
Ensembl chr16:32,555,015...32,602,754 		JBrowse link
G Myc myelocytomatosis oncogene ISO cornea RGD PMID:22149555 RGD:7240566 NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223 		JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha treatment IEP
ISO		 RGD PMID:19399405 PMID:31828147 RGD:10413870, RGD:35316072 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432 		JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell treatment ISO RGD PMID:29218089 RGD:13504718 NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472 		JBrowse link
G Nppa natriuretic peptide type A treatment ISO RGD PMID:23826817 RGD:7297054 NCBI chr 4:148,085,179...148,086,531
Ensembl chr 4:148,085,179...148,086,536 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 ISO protein:decreased activity:blood, mononuclear cell RGD PMID:10959477 RGD:7174721 NCBI chr18:39,543,598...39,652,485
Ensembl chr18:39,543,598...39,652,474 		JBrowse link
G Pdcd1 programmed cell death 1 severity ISO
IMP		 mRNA:increased expression:leukocytes, Mononuclear: RGD PMID:21518556 PMID:17198268 PMID:17489865 RGD:7248673, RGD:9589063, RGD:9589060 NCBI chr 1:93,966,027...93,980,278
Ensembl chr 1:93,966,027...93,980,278 		JBrowse link
G Pdgfd platelet-derived growth factor, D polypeptide ISO RGD PMID:19213942 RGD:9854642 NCBI chr 9:6,168,377...6,534,284
Ensembl chr 9:6,168,584...6,378,850 		JBrowse link
G Pdgfrb platelet derived growth factor receptor, beta polypeptide ISO RGD PMID:10458478 RGD:1625382 NCBI chr18:61,178,194...61,218,139
Ensembl chr18:61,178,222...61,218,133 		JBrowse link
G Pin1 peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1 ISO RGD PMID:17311089 RGD:8693431 NCBI chr 9:20,563,335...20,575,008
Ensembl chr 9:20,563,391...20,577,880 		JBrowse link
G Plat plasminogen activator, tissue susceptibility ISO protein:increased expression:plasma (human) RGD PMID:11423054 RGD:11541079 NCBI chr 8:23,247,655...23,272,864
Ensembl chr 8:23,247,743...23,272,860 		JBrowse link
G Plau plasminogen activator, urokinase ISO mRNA, protein:increased expression:kidney (human) RGD PMID:14531820 RGD:7241140 NCBI chr14:20,886,730...20,893,456
Ensembl chr14:20,886,728...20,893,453 		JBrowse link
G Prrc2a proline-rich coiled-coil 2A susceptibility ISO DNA:haplotype: :rs11538264(human) RGD PMID:25111513 RGD:14390152 NCBI chr17:35,368,052...35,384,877
Ensembl chr17:35,368,052...35,383,873 		JBrowse link
G Psmb9 proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) severity ISO protein:increased expression:liver, kidney (rat) RGD PMID:22834313 RGD:9854627 NCBI chr17:34,401,006...34,406,347
Ensembl chr17:34,400,961...34,406,738 		JBrowse link
G Rapgef3 Rap guanine nucleotide exchange factor (GEF) 3 treatment ISO RGD PMID:18178058 RGD:9835362 NCBI chr15:97,637,886...97,666,300
Ensembl chr15:97,642,651...97,665,853 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) treatment ISO RGD PMID:31828147 RGD:35316072 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Relb avian reticuloendotheliosis viral (v-rel) oncogene related B treatment ISO RGD PMID:23196258 RGD:7777161 NCBI chr 7:19,340,142...19,363,352
Ensembl chr 7:19,340,142...19,363,363 		JBrowse link
G Sell selectin, lymphocyte ISO RGD PMID:11095659 RGD:7175511 NCBI chr 1:163,889,556...163,908,354
Ensembl chr 1:163,889,551...163,911,750 		JBrowse link
G Slc5a7 solute carrier family 5 (choline transporter), member 7 ISO protein:increased expression:kidney, mononuclear cell RGD PMID:19201987 RGD:9999387 NCBI chr17:54,580,618...54,606,071
Ensembl chr17:54,580,618...54,606,062 		JBrowse link
G Spi1 Spi-1 proto-oncogene treatment ISO RGD PMID:24282365 RGD:9586451 NCBI chr 2:90,912,750...90,946,104
Ensembl chr 2:90,912,735...90,946,101 		JBrowse link
G Stat4 signal transducer and activator of transcription 4 ISO DNA:SNP: :rs7574865 (human) RGD PMID:21237270 RGD:7207871 NCBI chr 1:52,026,265...52,146,348
Ensembl chr 1:52,026,307...52,146,348 		JBrowse link
G Tbxa2r thromboxane A2 receptor ISO RGD PMID:7964472 RGD:11059606 NCBI chr10:81,164,102...81,171,008
Ensembl chr10:81,164,565...81,171,006 		JBrowse link
G Tlr2 toll-like receptor 2 IMP
ISO		 liver;DNA:SNP: :p.R753Q (human)
kidney		 RGD PMID:22042224 PMID:20038715 PMID:20090572 PMID:20628182 PMID:20628182 RGD:7207901, RGD:7240555, RGD:7240554, RGD:7240551, RGD:7240551 NCBI chr 3:83,743,579...83,749,045
Ensembl chr 3:83,743,579...83,749,074 		JBrowse link
G Tlr4 toll-like receptor 4 IMP pancreatic islet RGD PMID:20642685 PMID:20038715 RGD:7240548, RGD:7240555 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521 		JBrowse link
G Tlr9 toll-like receptor 9 susceptibility ISO kidney; DNA:snp:exon:g.+2848G>A rs352140 (human, North Indian) RGD PMID:22251233 RGD:7246885 NCBI chr 9:106,099,797...106,104,075
Ensembl chr 9:106,099,797...106,104,082 		JBrowse link
G Tnf tumor necrosis factor treatment ISO protein:increased expression:heart,serum: RGD PMID:2038191 PMID:2338821 PMID:8094579 RGD:7394793, RGD:8548836, RGD:7401188 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b ISO RGD PMID:19298452 RGD:7245520 NCBI chr 4:144,938,938...144,973,453
Ensembl chr 4:144,940,033...144,973,440 		JBrowse link
G Tpmt thiopurine methyltransferase ISO RGD PMID:24121523 RGD:11038722 NCBI chr13:47,175,463...47,196,833
Ensembl chr13:47,175,958...47,198,213 		JBrowse link
G Tpo thyroid peroxidase ISO RGD PMID:19506389 RGD:7207487 NCBI chr12:30,104,658...30,182,983
Ensembl chr12:30,104,658...30,182,623 		JBrowse link
G Traf2 TNF receptor-associated factor 2 treatment ISO RGD PMID:31828147 RGD:35316072 NCBI chr 2:25,407,994...25,436,952
Ensembl chr 2:25,407,994...25,436,952 		JBrowse link
G Xdh xanthine dehydrogenase treatment ISO RGD PMID:24768926 RGD:13209011 NCBI chr17:74,190,890...74,257,191
Ensembl chr17:74,190,890...74,257,191 		JBrowse link
Cardiac Allograft Vasculopathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F3 coagulation factor III ISO RGD PMID:9916935 RGD:11341701 NCBI chr 3:121,517,186...121,528,701
Ensembl chr 3:121,517,186...121,528,697 		JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K ISO RGD PMID:21489814 RGD:155260371 NCBI chr13:58,538,946...58,551,157
Ensembl chr13:58,538,956...58,551,157 		JBrowse link
G Pdgfd platelet-derived growth factor, D polypeptide ISO RGD PMID:19213942 RGD:9854642 NCBI chr 9:6,168,377...6,534,284
Ensembl chr 9:6,168,584...6,378,850 		JBrowse link
Chronic Allograft Dysfunction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor treatment ISO RGD PMID:22217518 PMID:23769041 RGD:7245568, RGD:8695995 NCBI chr17:34,816,545...34,819,911
Ensembl chr17:34,816,836...34,819,910 		JBrowse link
G C3 complement component 3 treatment ISO RGD PMID:25122638 RGD:11040803 NCBI chr17:57,510,967...57,535,136
Ensembl chr17:57,510,970...57,535,136 		JBrowse link
G Cd40 CD40 antigen treatment ISO RGD PMID:22826618 RGD:11352297 NCBI chr 2:164,897,535...164,913,574
Ensembl chr 2:164,897,547...164,914,868 		JBrowse link
G Cd40lg CD40 ligand treatment ISO liver RGD PMID:22826618 RGD:11352297 NCBI chr  X:56,257,448...56,269,402
Ensembl chr  X:56,257,503...56,269,402 		JBrowse link
G F7 coagulation factor VII treatment ISO human protein in a rat model RGD PMID:12095034 RGD:11049508 NCBI chr 8:13,075,499...13,085,809
Ensembl chr 8:13,076,034...13,085,809 		JBrowse link
G Hmgb1 high mobility group box 1 treatment ISO RGD PMID:22217518 RGD:7245568 NCBI chr 5:148,983,512...148,989,867
Ensembl chr 5:148,983,512...149,121,299 		JBrowse link
G Kcnn4 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 ameliorates ISO RGD PMID:24312257 RGD:401700379 NCBI chr 7:24,069,750...24,084,635
Ensembl chr 7:24,069,688...24,086,115 		JBrowse link
G Mtor mechanistic target of rapamycin kinase treatment ISO RGD PMID:23985719 RGD:10041002 NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140 		JBrowse link
G Tnf tumor necrosis factor treatment ISO RGD PMID:24598936 RGD:10450586 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
Chronic Allograft Nephropathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aco1 aconitase 1 ISO RGD PMID:20176611 RGD:11541086 NCBI chr 4:40,143,429...40,199,011
Ensembl chr 4:40,143,081...40,198,338 		JBrowse link
G Alb albumin disease_progression ISO RGD PMID:24370342 RGD:11035281 NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 ISO RGD PMID:17298994 RGD:7241819 NCBI chr11:83,538,669...83,540,204
Ensembl chr11:83,538,670...83,540,181 		JBrowse link
G Ccn2 cellular communication network factor 2 disease_progression ISO mRNA, protein:increased expression:kidney (rat) RGD PMID:19921985 RGD:150517553 NCBI chr10:24,471,340...24,474,581
Ensembl chr10:24,471,340...24,474,581 		JBrowse link
G Clu clusterin treatment ISO RGD PMID:22494435 RGD:9068431 NCBI chr14:66,206,093...66,218,992
Ensembl chr14:66,205,932...66,218,996 		JBrowse link
G Cs citrate synthase treatment ISO RGD PMID:20005400 RGD:243048470 NCBI chr10:128,173,596...128,198,351
Ensembl chr10:128,173,603...128,198,348 		JBrowse link
G Mmp3 matrix metallopeptidase 3 ISO RGD PMID:22845765 RGD:7241226 NCBI chr 9:7,445,845...7,455,975
Ensembl chr 9:7,445,822...7,455,975 		JBrowse link
G Mmp7 matrix metallopeptidase 7 treatment ISO RGD PMID:18209025 RGD:9685339 NCBI chr 9:7,692,095...7,699,587
Ensembl chr 9:7,692,091...7,699,586 		JBrowse link
G Pdgfa platelet derived growth factor, alpha ISO RGD PMID:11889420 RGD:11080974 NCBI chr 5:138,961,761...138,986,336
Ensembl chr 5:138,961,769...138,983,125 		JBrowse link
G Pdgfb platelet derived growth factor, B polypeptide ISO mRNA:increased expression:kidney: RGD PMID:15785371 PMID:11889420 RGD:10449491, RGD:11080974 NCBI chr15:79,880,066...79,899,178
Ensembl chr15:79,880,075...79,899,178 		JBrowse link
G Pdgfra platelet derived growth factor receptor, alpha polypeptide ISO RGD PMID:11889420 RGD:11080974 NCBI chr 5:75,311,988...75,358,867
Ensembl chr 5:75,312,953...75,358,876 		JBrowse link
G Pdgfrb platelet derived growth factor receptor, beta polypeptide ISO RGD PMID:11889420 RGD:11080974 NCBI chr18:61,178,194...61,218,139
Ensembl chr18:61,178,222...61,218,133 		JBrowse link
G Plau plasminogen activator, urokinase ISO protein:increased secretion:T lymphocyte (human) RGD PMID:16387096 RGD:7241259 NCBI chr14:20,886,730...20,893,456
Ensembl chr14:20,886,728...20,893,453 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma ISO protein:increased expression:kidney: RGD PMID:16221712 RGD:13208600 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 treatment ISO protein:increased expression:kidney: RGD PMID:16221712 PMID:18192922 RGD:13208600, RGD:13208601 NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122 		JBrowse link
Chronic Lung Allograft Dysfunction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Epas1 endothelial PAS domain protein 1 ISO mRNA:increased expression:lung RGD PMID:22305384 RGD:10395369 NCBI chr17:87,061,292...87,140,838
Ensembl chr17:87,061,128...87,140,838 		JBrowse link
Corneal Graft Rejection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd274 CD274 antigen treatment ISO RGD PMID:22300371 RGD:41412184 NCBI chr19:29,339,428...29,365,495
Ensembl chr19:29,344,855...29,365,495 		JBrowse link
G Cd4 CD4 antigen treatment ISO RGD PMID:1358194 RGD:10059315 NCBI chr 6:124,841,656...124,865,210
Ensembl chr 6:124,841,655...124,865,184 		JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO human gene in a rat model RGD PMID:23723965 RGD:9684950 NCBI chr 2:24,226,872...24,241,503
Ensembl chr 2:24,226,865...24,241,506 		JBrowse link
heart transplant rejection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fto FTO alpha-ketoglutarate dependent dioxygenase ISO DNA:SNP: :rs17817449 (human) RGD PMID:30408245 RGD:329845888 NCBI chr 8:92,039,995...92,395,061
Ensembl chr 8:92,040,153...92,395,067 		JBrowse link
Primary Graft Dysfunction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccn2 cellular communication network factor 2 exacerbates ISO protein:increased expression:urine (rat) RGD PMID:19921985 RGD:150517553 NCBI chr10:24,471,340...24,474,581
Ensembl chr10:24,471,340...24,474,581 		JBrowse link
G Cd40lg CD40 ligand treatment IMP RGD PMID:12244161 RGD:7248713 NCBI chr  X:56,257,448...56,269,402
Ensembl chr  X:56,257,503...56,269,402 		JBrowse link
G Gata2 GATA binding protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28569748 NCBI chr 6:88,170,873...88,184,014
Ensembl chr 6:88,170,873...88,184,014 		JBrowse link
G Gpx3 glutathione peroxidase 3 treatment ISO RGD PMID:29290803 RGD:401827126 NCBI chr11:54,793,680...54,801,213
Ensembl chr11:54,793,279...54,801,203 		JBrowse link
G Icam1 intercellular adhesion molecule 1 treatment ISO RGD PMID:22617707 PMID:10666412 RGD:8547722, RGD:11520779 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113 		JBrowse link
G Il10 interleukin 10 treatment ISO RGD PMID:21911153 RGD:11049478 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Npy neuropeptide Y ISO mRNA, protein:decreased expression:blood, mononuclear cell RGD PMID:18981110 RGD:10448956 NCBI chr 6:49,799,690...49,806,487
Ensembl chr 6:49,799,690...49,806,487 		JBrowse link
G Pf4 platelet factor 4 ameliorates ISO RGD PMID:24986443 RGD:329901907 NCBI chr 5:90,920,362...90,921,242
Ensembl chr 5:90,920,294...90,921,242 		JBrowse link
G Selp selectin, platelet ISO CTD Direct Evidence: marker/mechanism CTD PMID:28569748 NCBI chr 1:163,942,833...163,977,595
Ensembl chr 1:163,942,833...163,977,595 		JBrowse link
G Senp1 SUMO1/sentrin specific peptidase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28569748 NCBI chr15:97,936,625...97,991,625
Ensembl chr15:97,936,625...97,991,625 		JBrowse link
G Tnf tumor necrosis factor treatment ISO liver RGD PMID:18972563 RGD:15023490 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28569748 NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18301
    disease of anatomical entity 15631
      immune system disease 4464
        Transplant Rejection 123
          Chronic Allograft Dysfunction + 28
          Corneal Graft Rejection 3
          Primary Graft Dysfunction 12
          heart transplant rejection 1
Path 2
Term Annotations click to browse term
  disease 18301
    disease of anatomical entity 15631
      Immune & Inflammatory Diseases 5172
        immune system disease 4464
          Transplant Rejection 123
            Chronic Allograft Dysfunction + 28
            Corneal Graft Rejection 3
            Primary Graft Dysfunction 12
            heart transplant rejection 1
paths to the root