Spi1 (spleen focus forming virus (SFFV) proviral integration oncogene) - Rat Genome Database

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Gene: Spi1 (spleen focus forming virus (SFFV) proviral integration oncogene) Mus musculus
Symbol: Spi1
Name: spleen focus forming virus (SFFV) proviral integration oncogene
RGD ID: 1553307
Description: Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; NFAT protein binding activity; and histone deacetylase binding activity. Involved in several processes, including lymphocyte differentiation; regulation of gene expression; and regulation of myeloid leukocyte mediated immunity. Acts upstream of or within several processes, including apoptotic process involved in blood vessel morphogenesis; hemopoiesis; and regulation of transcription, DNA-templated. Located in chromatin and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and respiratory system. Used to study acute myeloid leukemia. Orthologous to human SPI1 (Spi-1 proto-oncogene); PARTICIPATES IN DNA modification pathway; interleukin-4 signaling pathway; acute myeloid leukemia pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 31 kDa-transforming protein; Dis; Dis-1; Dis1; hematopoietic transcription factor PU.1; PU.; PU.1; Sf; SFFV proviral integration 1 protein; Sfp; Sfpi-1; Sfpi1; Sp; Spi-1; Tcfpu; Tcfpu1; Tfpu.; Tfpu.1; transcription factor PU.1
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39290,912,750 - 90,946,104 (+)NCBIGRCm39mm39
GRCm39 Ensembl290,912,735 - 90,946,101 (+)Ensembl
GRCm38291,082,374 - 91,115,759 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl291,082,390 - 91,115,756 (+)EnsemblGRCm38mm10GRCm38
MGSCv37290,936,954 - 90,955,913 (+)NCBIGRCm37mm9NCBIm37
MGSCv36290,897,636 - 90,916,595 (+)NCBImm8
Celera292,481,297 - 92,500,928 (+)NCBICelera
Cytogenetic Map2E1NCBI
cM Map250.44NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anatomical structure regression  (IMP)
apoptotic process involved in blood vessel morphogenesis  (IMP)
cell differentiation  (IBA)
cellular response to ethanol  (ISO)
chromatin organization involved in regulation of transcription  (IMP)
defense response to tumor cell  (ISO)
endothelial to hematopoietic transition  (IEP)
erythrocyte differentiation  (IMP)
follicular B cell differentiation  (IGI)
germinal center B cell differentiation  (IGI)
granulocyte differentiation  (IDA)
histone H3 acetylation  (ISO)
hypermethylation of CpG island  (ISO)
immature B cell differentiation  (IGI)
interleukin-6-mediated signaling pathway  (ISO)
lipopolysaccharide-mediated signaling pathway  (IMP)
lymphocyte differentiation  (IDA)
lymphoid progenitor cell differentiation  (IMP)
macrophage differentiation  (IDA)
myeloid dendritic cell differentiation  (IMP)
myeloid leukocyte differentiation  (IMP,ISO)
negative regulation of adipose tissue development  (IMP)
negative regulation of gene expression  (IMP,ISO)
negative regulation of gene expression, epigenetic  (ISO)
negative regulation of histone H4 acetylation  (ISO)
negative regulation of MHC class II biosynthetic process  (IDA)
negative regulation of neutrophil degranulation  (IMP)
negative regulation of NF-kappaB transcription factor activity  (ISO)
negative regulation of NIK/NF-kappaB signaling  (ISO)
negative regulation of protein localization to chromatin  (IMP)
negative regulation of transcription by RNA polymerase II  (IDA,IMP,ISO)
negative regulation of transcription, DNA-templated  (IMP,ISO)
oncogene-induced cell senescence  (IDA)
pericyte cell differentiation  (IMP)
positive regulation of antifungal innate immune response  (IMP)
positive regulation of gene expression  (IMP)
positive regulation of microglial cell mediated cytotoxicity  (IMP)
positive regulation of myeloid dendritic cell chemotaxis  (IMP)
positive regulation of p38MAPK cascade  (IDA)
positive regulation of pri-miRNA transcription by RNA polymerase II  (IDA,ISO)
positive regulation of transcription by RNA polymerase II  (IDA,IGI,IMP,ISO)
positive regulation of transcription, DNA-templated  (IDA,ISO)
pro-T cell differentiation  (IMP)
regulation of DNA-binding transcription factor activity  (IMP)
regulation of erythrocyte differentiation  (ISO)
regulation of histone H3-K27 acetylation  (IDA)
regulation of myeloid progenitor cell differentiation  (IMP)
regulation of transcription by RNA polymerase II  (IBA,IDA)
regulation of transcription, DNA-templated  (IDA,ISO)
somatic stem cell population maintenance  (IDA)
TRAIL-activated apoptotic signaling pathway  (ISO)
transforming growth factor beta receptor signaling pathway  (IMP)
vasculature development  (IMP)

Cellular Component
chromatin  (IDA,ISO)
nucleoplasm  (ISO,TAS)
nucleus  (IBA,IDA,ISO)
transcription regulator complex  (IC,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal astrocyte morphology  (IAGP)
abnormal B cell differentiation  (IAGP)
abnormal B cell number  (IAGP)
abnormal blood cell morphology/development  (IAGP)
abnormal bone marrow cell morphology/development  (IAGP)
abnormal bone marrow morphology  (IAGP)
abnormal cell cycle  (IAGP)
abnormal chromosome number  (IAGP)
abnormal common myeloid progenitor cell morphology  (IAGP)
abnormal definitive hematopoiesis  (IAGP)
abnormal double-negative T cell morphology  (IAGP)
abnormal erythrocyte cell number  (IAGP)
abnormal erythropoiesis  (IAGP)
abnormal eye development  (IAGP)
abnormal fetal derived definitive erythrocyte cell number  (IAGP)
abnormal granulocyte differentiation  (IAGP)
abnormal granulocyte morphology  (IAGP)
abnormal hematopoietic stem cell physiology  (IAGP)
abnormal hematopoietic system physiology  (IAGP)
abnormal immature B cell morphology  (IAGP)
abnormal leukopoiesis  (IAGP)
abnormal liver morphology  (IAGP)
abnormal macrophage differentiation  (IAGP)
abnormal microglial cell morphology  (IAGP)
abnormal monocyte morphology  (IAGP)
abnormal myelopoiesis  (IAGP)
abnormal neutrophil differentiation  (IAGP)
abnormal proerythroblast morphology  (IAGP)
abnormal spleen germinal center morphology  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal T cell differentiation  (IAGP)
abnormal T cell number  (IAGP)
abnormal T cell subpopulation ratio  (IAGP)
absent B cells  (IAGP)
absent common myeloid progenitor cells  (IAGP)
absent erythrocytes  (IAGP)
absent mature B cells  (IAGP)
absent spleen germinal center  (IAGP)
anemia  (IAGP)
arrested B cell differentiation  (IAGP)
decreased B cell number  (IAGP)
decreased B cell proliferation  (IAGP)
decreased B-1a cell number  (IAGP)
decreased body size  (IAGP)
decreased CD4-positive, alpha beta T cell number  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased double-negative T cell number  (IAGP)
decreased double-positive T cell number  (IAGP)
decreased granulocyte number  (IAGP)
decreased hematocrit  (IAGP)
decreased hematopoietic stem cell number  (IAGP)
decreased macrophage cell number  (IAGP)
decreased mature B cell number  (IAGP)
decreased motor neuron number  (IAGP)
decreased neutrophil cell number  (IAGP)
decreased pre-B cell number  (IAGP)
decreased pro-B cell number  (IAGP)
decreased spleen red pulp amount  (IAGP)
decreased T cell number  (IAGP)
decreased thymocyte number  (IAGP)
decreased thymus weight  (IAGP)
enlarged liver  (IAGP)
enlarged spleen  (IAGP)
extramedullary hematopoiesis  (IAGP)
failure of myelopoiesis  (IAGP)
failure of tooth eruption  (IAGP)
hemorrhage  (IEA)
impaired myelopoiesis  (IAGP)
increased B cell apoptosis  (IAGP)
increased B-1 B cell number  (IAGP)
increased B-1b cell number  (IAGP)
increased bone marrow cell number  (IAGP)
increased double-negative T cell number  (IAGP)
increased granulocyte number  (IAGP)
increased hematopoietic stem cell number  (IAGP)
increased hematopoietic stem cell proliferation  (IAGP)
increased IgM level  (IAGP)
increased leukemia incidence  (IAGP)
increased liver weight  (IAGP)
increased lymphocyte cell number  (IAGP)
increased neutrophil cell number  (IAGP)
increased spleen weight  (IAGP)
increased T cell derived lymphoma incidence  (IAGP)
increased T cell number  (IAGP)
increased tumor incidence  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
liver hyperplasia  (IAGP)
motor neuron degeneration  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
osteopetrosis  (IAGP)
persistence of hyaloid vascular system  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
preweaning lethality, complete penetrance  (IEA)
sepsis  (IAGP)
small thymus  (IAGP)
spleen hyperplasia  (IAGP)

Additional References at PubMed
PMID:1406622   PMID:1409581   PMID:1571554   PMID:1985210   PMID:2180582   PMID:2338340   PMID:2594367   PMID:2827041   PMID:2835657   PMID:7558020   PMID:7592651   PMID:7624372  
PMID:7750469   PMID:7769664   PMID:7822329   PMID:7835084   PMID:8034327   PMID:8079170   PMID:8093609   PMID:8242633   PMID:8268661   PMID:8570653   PMID:8602247   PMID:8626664  
PMID:8631753   PMID:8662221   PMID:8777716   PMID:8786144   PMID:8808291   PMID:8896458   PMID:9052784   PMID:9096311   PMID:9133423   PMID:9545490   PMID:9545497   PMID:9573007  
PMID:9590129   PMID:9611252   PMID:9618756   PMID:9687512   PMID:9716585   PMID:9811459   PMID:9885975   PMID:10050886   PMID:10203717   PMID:10216079   PMID:10229183   PMID:10349636  
PMID:10438716   PMID:10441734   PMID:10453009   PMID:10453070   PMID:10498603   PMID:10501973   PMID:10502132   PMID:10577501   PMID:10594242   PMID:10648399   PMID:10657634   PMID:10840049  
PMID:11027604   PMID:11042159   PMID:11076747   PMID:11076861   PMID:11133986   PMID:11217851   PMID:11481336   PMID:11672537   PMID:11829488   PMID:11841229   PMID:11861656   PMID:11869689  
PMID:11980719   PMID:11997509   PMID:12027437   PMID:12051816   PMID:12130514   PMID:12393686   PMID:12444140   PMID:12453417   PMID:12459275   PMID:12466851   PMID:12477932   PMID:12515729  
PMID:12543105   PMID:12612065   PMID:12695521   PMID:12729756   PMID:12739003   PMID:12842011   PMID:14610273   PMID:14635793   PMID:14644098   PMID:14647452   PMID:14659744   PMID:14662861  
PMID:14681479   PMID:14688320   PMID:14697219   PMID:14739214   PMID:14960357   PMID:14962802   PMID:14962908   PMID:14966110   PMID:14976051   PMID:14998994   PMID:15013752   PMID:15064749  
PMID:15100295   PMID:15146183   PMID:15187136   PMID:15304324   PMID:15304397   PMID:15304486   PMID:15328162   PMID:15361867   PMID:15469848   PMID:15489334   PMID:15611261   PMID:15616565  
PMID:15618518   PMID:15642097   PMID:15657291   PMID:15728493   PMID:15766566   PMID:15781329   PMID:15867096   PMID:15882585   PMID:15914556   PMID:15914564   PMID:15933053   PMID:15963784  
PMID:16002702   PMID:16051608   PMID:16083856   PMID:16093364   PMID:16098914   PMID:16113082   PMID:16139904   PMID:16141072   PMID:16141073   PMID:16141339   PMID:16163358   PMID:16183743  
PMID:16210620   PMID:16222338   PMID:16292344   PMID:16301746   PMID:16311598   PMID:16313959   PMID:16365419   PMID:16432184   PMID:16616894   PMID:16680826   PMID:16702405   PMID:16707500  
PMID:16709844   PMID:16709865   PMID:16735694   PMID:16861236   PMID:16880393   PMID:16887979   PMID:16917076   PMID:16925795   PMID:16951689   PMID:17041602   PMID:17043238   PMID:17064678  
PMID:17088084   PMID:17116688   PMID:17132716   PMID:17197705   PMID:17277151   PMID:17309818   PMID:17360957   PMID:17403683   PMID:17403896   PMID:17476283   PMID:17562868   PMID:17586044  
PMID:17588474   PMID:17623651   PMID:17629523   PMID:17641192   PMID:17644741   PMID:17694175   PMID:17785440   PMID:17827340   PMID:17907201   PMID:17913791   PMID:17923506   PMID:17977828  
PMID:17989716   PMID:17994017   PMID:18063754   PMID:18173740   PMID:18287559   PMID:18354487   PMID:18371378   PMID:18375040   PMID:18384814   PMID:18404378   PMID:18463231   PMID:18485892  
PMID:18523151   PMID:18560381   PMID:18680724   PMID:18692240   PMID:18759249   PMID:18787208   PMID:18800919   PMID:18805961   PMID:18809917   PMID:19046990   PMID:19104054   PMID:19167354  
PMID:19181746   PMID:19288495   PMID:19289502   PMID:19339695   PMID:19379700   PMID:19397448   PMID:19397449   PMID:19422845   PMID:19491391   PMID:19564417   PMID:19592658   PMID:19646961  
PMID:19796622   PMID:19801513   PMID:19818654   PMID:19955566   PMID:20035012   PMID:20059953   PMID:20064451   PMID:20065023   PMID:20142327   PMID:20190819   PMID:20206554   PMID:20211142  
PMID:20304827   PMID:20363966   PMID:20404134   PMID:20418886   PMID:20431622   PMID:20510871   PMID:20513432   PMID:20525788   PMID:20554972   PMID:20638124   PMID:20647008   PMID:20660370  
PMID:20696839   PMID:20932939   PMID:20978081   PMID:21057087   PMID:21119111   PMID:21216962   PMID:21239694   PMID:21267068   PMID:21308778   PMID:21474105   PMID:21518930   PMID:21555536  
PMID:21571370   PMID:21677750   PMID:21695229   PMID:21725055   PMID:21730352   PMID:21757649   PMID:21768304   PMID:21779390   PMID:21873635   PMID:21878674   PMID:21897363   PMID:21937699  
PMID:22056786   PMID:22083997   PMID:22096565   PMID:22112519   PMID:22158964   PMID:22167804   PMID:22231443   PMID:22279106   PMID:22284677   PMID:22308484   PMID:22357756   PMID:22426104  
PMID:22454293   PMID:22510988   PMID:22533913   PMID:22696442   PMID:22842344   PMID:22897850   PMID:22904310   PMID:22956576   PMID:23056458   PMID:23284905   PMID:23334579   PMID:23340137  
PMID:23376058   PMID:23395001   PMID:23416556   PMID:23444353   PMID:23509362   PMID:23575636   PMID:23623495   PMID:23727242   PMID:23775123   PMID:23852375   PMID:23868921   PMID:23936136  
PMID:23980096   PMID:24037986   PMID:24086757   PMID:24121269   PMID:24194600   PMID:24216482   PMID:24249112   PMID:24278366   PMID:24316397   PMID:24445817   PMID:24813947   PMID:24908389  
PMID:25076114   PMID:25094047   PMID:25185713   PMID:25252941   PMID:25288398   PMID:25288399   PMID:25331958   PMID:25409310   PMID:25505273   PMID:25529853   PMID:25733685   PMID:25765478  
PMID:25846797   PMID:25870109   PMID:25912686   PMID:26012552   PMID:26097038   PMID:26101328   PMID:26117255   PMID:26147683   PMID:26343801   PMID:26361334   PMID:26363052   PMID:26447946  
PMID:26546825   PMID:26754935   PMID:26779602   PMID:26932576   PMID:27001747   PMID:27111842   PMID:27135602   PMID:27270080   PMID:27411635   PMID:27506447   PMID:27566938   PMID:27607579  
PMID:27705792   PMID:27708417   PMID:28002729   PMID:28062693   PMID:28325862   PMID:28329690   PMID:28338898   PMID:28347818   PMID:28628103   PMID:28790174   PMID:28912174   PMID:29083320  
PMID:29127283   PMID:29138493   PMID:29162670   PMID:29386516   PMID:29436414   PMID:29453291   PMID:29704636   PMID:29847803   PMID:29924977   PMID:29942304   PMID:30061199   PMID:30171019  
PMID:30171089   PMID:30252950   PMID:30258231   PMID:30301719   PMID:30315161   PMID:30355733   PMID:30412053   PMID:30413670   PMID:30484118   PMID:30571485   PMID:30611612   PMID:30700907  
PMID:30718772   PMID:30721543   PMID:30911105   PMID:30986495   PMID:31000603   PMID:31314592   PMID:31501274   PMID:31560640   PMID:31586032   PMID:31611602   PMID:31644907   PMID:31646336  
PMID:31729420   PMID:31932499   PMID:32369453   PMID:32611724   PMID:32633839   PMID:32661179   PMID:32756905   PMID:33052238   PMID:33462113   PMID:33932339  


Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39290,912,750 - 90,946,104 (+)NCBIGRCm39mm39
GRCm39 Ensembl290,912,735 - 90,946,101 (+)Ensembl
GRCm38291,082,374 - 91,115,759 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl291,082,390 - 91,115,756 (+)EnsemblGRCm38mm10GRCm38
MGSCv37290,936,954 - 90,955,913 (+)NCBIGRCm37mm9NCBIm37
MGSCv36290,897,636 - 90,916,595 (+)NCBImm8
Celera292,481,297 - 92,500,928 (+)NCBICelera
Cytogenetic Map2E1NCBI
cM Map250.44NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1147,354,860 - 47,378,547 (-)EnsemblGRCh38hg38GRCh38
GRCh381147,354,859 - 47,395,640 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371147,376,411 - 47,400,098 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361147,332,985 - 47,356,703 (-)NCBINCBI36hg18NCBI36
Build 341147,332,987 - 47,356,674NCBI
Celera1147,515,686 - 47,541,505 (-)NCBI
Cytogenetic Map11p11.2NCBI
HuRef1147,075,532 - 47,099,721 (-)NCBIHuRef
CHM1_11147,375,652 - 47,399,367 (-)NCBICHM1_1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2377,059,744 - 77,093,730 (+)NCBI
Rnor_6.0 Ensembl379,918,969 - 79,938,301 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0379,918,127 - 79,937,708 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0386,627,684 - 86,646,468 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4375,456,353 - 75,475,722 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1375,352,724 - 75,372,093 (+)NCBI
Celera376,282,068 - 76,300,680 (+)NCBICelera
Cytogenetic Map3q24NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_004955422873,735 - 886,560 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955422873,735 - 886,560 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.11147,853,991 - 47,880,259 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1147,853,991 - 47,880,259 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01147,301,245 - 47,326,891 (-)NCBIMhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11842,253,849 - 42,269,497 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1842,253,811 - 42,269,727 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1840,983,530 - 40,999,141 (+)NCBI
ROS_Cfam_1.01842,908,919 - 42,924,536 (+)NCBI
UMICH_Zoey_3.11842,395,271 - 42,410,877 (+)NCBI
UNSW_CanFamBas_1.01841,950,490 - 41,966,095 (+)NCBI
UU_Cfam_GSD_1.01842,679,725 - 42,695,395 (+)NCBI
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494719,741,101 - 19,757,903 (+)NCBI
SpeTri2.0NW_0049365621,852,759 - 1,870,647 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl215,227,829 - 15,245,667 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1215,227,850 - 15,245,679 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2216,434,712 - 16,452,518 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1117,935,037 - 17,961,638 (+)NCBI
ChlSab1.1 Ensembl117,935,922 - 17,961,717 (+)Ensembl
Vero_WHO_p1.0NW_023666038115,237,583 - 115,263,142 (+)NCBI
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_0046247671,376,649 - 1,404,382 (+)NCBI

Position Markers
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38291,115,608 - 91,115,705UniSTSGRCm38
MGSCv37290,955,765 - 90,955,862UniSTSGRCm37
Celera292,500,780 - 92,500,877UniSTS
Cytogenetic Map2E3UniSTS
cM Map247.5UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38291,115,547 - 91,115,626UniSTSGRCm38
MGSCv37290,955,704 - 90,955,783UniSTSGRCm37
Celera292,500,719 - 92,500,798UniSTS
Cytogenetic Map2E3UniSTS
cM Map247.5UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2E3UniSTS
cM Map247.5UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2E3UniSTS

QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301769Orgwq2_morgan weight QTL 2 (mouse)Not determined2388608993591306Mouse
1357454Kidq1_mkidney weight QTL 1 (mouse)Not determined220892967119064359Mouse
1357436Splq1_mspleen weight QTL 1 (mouse)Not determined220892967119064359Mouse
1357829Lvrq1_mliver weight QTL 1 (mouse)Not determined220892967119064359Mouse
1558899Egq1_mearly growth QTL 1 (mouse)Not determined220892967119064359Mouse
1558738W6q1_mweight 6 weeks QTL 1 (mouse)Not determined220892967119064359Mouse
1558966W10q9_mweight 10 weeks QTL 9 (mouse)Not determined220892967119064359Mouse
1558915W3q1_mweight 3 weeks QTL 1 (mouse)Not determined220892967119064359Mouse
1357681Hrtq1_mheart weight QTL 1 (mouse)Not determined220892967119064359Mouse
1357881Estoq1_membryo survival total QTL 1 (mouse)Not determined220892967119064359Mouse
39128209Lwq14_mliver weight QTL 14 (mouse)220892967119064359Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224334620148858457Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229417935148533014Mouse
4141236Hbnr5_mHeligmosomoides bakeri nematode resistance 5 (mouse)Not determined31324555105313225Mouse
1301109Dntcs2_mdental caries susceptibility 2 (mouse)Not determined240995481115079684Mouse
1301344Lith1_mlithogenic gene 1 (mouse)Not determined245457623145470727Mouse
4141406Alpq2_malcohol preference QTL 2 (mouse)Not determined25769377391693944Mouse
12738429Lfibq18_mliver fibrosis QTL 18 (mouse)25808964792089647Mouse
1357577Trmq3_mT cell ratio modifier QTL 3 (mouse)Not determined260690268119525037Mouse
13824983Vclq1_mcurvilinear velocity QTL 1 (mouse)262000000137000000Mouse
1300662Etohila_methanol induced locomotor activity (mouse)Not determined26317561097175769Mouse
1301405Etohr_methanol response acute (mouse)Not determined26317561097175769Mouse
1301703Bomd3_mbone mineral density 3 (mouse)Not determined26317561097175769Mouse
10044002Hdl7_mHDL level 7 (mouse)Not determined26317561097175769Mouse
10053681Lith24_mlithogenic gene 24 (mouse)Not determined26317561097175769Mouse
1301048Actre2_mactivity response to ethanol 2 (mouse)Not determined26317561097175769Mouse
1301873Hsl1_mhyperoxia susceptibility locus 1 (mouse)Not determined26373981097739957Mouse
5491197Mobq5_mmultigenic obesity QTL 5 (mouse)Not determined265439402162677006Mouse
1301660Iba1_minduction of brown adipocytes 1 (mouse)Not determined267817543101817798Mouse
13463482Mchq17_mmean corpuscular hemoglobin QTL 17 (mouse)267817543101817798Mouse
1301948Elsgp3_melevated serum gp70 3 (mouse)Not determined268893925102894063Mouse
1301882Etohc2_methanol consumption 2 (mouse)Not determined268893925102894063Mouse
4142088Parms1_mpatched associated RMS 1 (mouse)Not determined74693773114293051Mouse
11528549Sluc31_msusceptibility to lung cancer 31 (mouse)274693773129371085Mouse
1301374Cplaq7_mcircadian period of locomotor activity 7 (mouse)Not determined276591138110591306Mouse
4141657Mohg1_mmodifier of hg 1 (mouse)Not determined276848414103265478Mouse
10043894Bw22_mbody weight QTL 22 (mouse)Not determined281064989115064989Mouse
1558901Skmw8_mskeletal muscle weight 8 (mouse)Not determined284178143118178248Mouse
4141155Plast2b_mplasma plant sterol 2b (mouse)Not determined284182854148680255Mouse
10412082Hylaq1_mHyperlocomotor activity related QTL 1 (mouse)Not determined284182854148825550Mouse
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285893925181254801Mouse
11038697Ltpr2d_mLeishmania tropica response 2d (mouse)286265371120265478Mouse
11038698Ltpr2c_mLeishmania tropica response 2c (mouse)286265371120265478Mouse
1300852Lmr14_mleishmaniasis resistance 14 (mouse)Not determined286265371120265478Mouse
11049565Lmr28g_mleishmaniasis resistance 28g (mouse)286265371120265478Mouse
1301834Bits1_mbitterness sensitivity 1 (mouse)Not determined287610298121610433Mouse
11532731Sluc31a_msusceptibility to lung cancer 31a (mouse)288184658122184825Mouse
4142223Femwf4_mfemur work to failure 4 (mouse)Not determined88313078122313225Mouse

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir155mmu-miR-155-5pMirtarbaseexternal_infoReporter assay;OtherFunctional MTI18055230
Mir126ammu-miR-126a-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI21163928

Predicted Target Of
Summary Value
Count of predictions:731
Count of miRNA genes:459
Interacting mature miRNAs:527
Transcripts:ENSMUST00000002180, ENSMUST00000131400, ENSMUST00000132741, ENSMUST00000169852
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.



Nucleotide Sequences
RefSeq Transcripts NM_001378898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001378899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_011355 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA239990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AA789819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK142246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154945 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL691450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC003815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ187167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L03215 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M32370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M38252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X17463 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000002180   ⟹   ENSMUSP00000002180
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl291,096,096 - 91,115,756 (+)Ensembl
RefSeq Acc Id: ENSMUST00000131400
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl291,082,408 - 91,090,310 (+)Ensembl
RefSeq Acc Id: ENSMUST00000132741   ⟹   ENSMUSP00000128457
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl291,096,780 - 91,113,315 (+)Ensembl
RefSeq Acc Id: ENSMUST00000169852   ⟹   ENSMUSP00000130368
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl291,082,390 - 91,114,366 (+)Ensembl
RefSeq Acc Id: NM_001378898   ⟹   NP_001365827
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm39290,927,045 - 90,946,102 (+)NCBI
GRCm38291,096,700 - 91,115,757 (+)NCBI
RefSeq Acc Id: NM_001378899   ⟹   NP_001365828
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm39290,912,750 - 90,946,102 (+)NCBI
GRCm38291,082,405 - 91,115,757 (+)NCBI
RefSeq Acc Id: NM_011355   ⟹   NP_035485
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm39290,927,023 - 90,946,104 (+)NCBI
GRCm38291,096,678 - 91,115,759 (+)NCBI
MGSCv37290,936,954 - 90,955,913 (+)RGD
Celera292,481,297 - 92,500,928 (+)RGD
Reference Sequences
RefSeq Acc Id: NP_035485   ⟸   NM_011355
- Peptide Label: isoform 2
- UniProtKB: P17433 (UniProtKB/Swiss-Prot),   Q3U5L4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001365828   ⟸   NM_001378899
- Peptide Label: isoform 3
RefSeq Acc Id: NP_001365827   ⟸   NM_001378898
- Peptide Label: isoform 1
RefSeq Acc Id: ENSMUSP00000128457   ⟸   ENSMUST00000132741
RefSeq Acc Id: ENSMUSP00000002180   ⟸   ENSMUST00000002180
RefSeq Acc Id: ENSMUSP00000130368   ⟸   ENSMUST00000169852
Protein Domains

RGD ID:6832687
Promoter ID:MM_KWN:30445
SO ACC ID:SO:0000170
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Lung,   Spleen
Transcripts:OTTMUST00000033994,   OTTMUST00000033995
Mouse AssemblyChrPosition (strand)Source
MGSCv36290,935,286 - 90,937,147 (+)MPROMDB
RGD ID:6877884
Promoter ID:EPDNEW_M2393
Type:initiation region
Description:Mus musculus spleen focus forming virus proviral integrationoncogene , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm38291,096,760 - 91,096,820EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:98282 AgrOrtholog
Ensembl Genes ENSMUSG00000002111 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000002180 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000128457 UniProtKB/TrEMBL
  ENSMUSP00000130368 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000002180 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000132741 UniProtKB/TrEMBL
  ENSMUST00000169852 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ets_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:20375 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ets UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Spi1 PhenoGen
  ETS_DOMAIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ETS_DOMAIN_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ETS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPI1_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q99L57 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-06 Spi1  spleen focus forming virus (SFFV) proviral integration oncogene  Sfpi1  SFFV proviral integration 1  Symbol and/or name change 5135510 APPROVED