Gata2 (GATA binding protein 2) - Rat Genome Database
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Gene: Gata2 (GATA binding protein 2) Mus musculus
Analyze
Symbol: Gata2
Name: GATA binding protein 2
RGD ID: 69110
MGI Page MGI
Description: Exhibits DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including animal organ development; regulation of myeloid cell differentiation; and regulation of transcription by RNA polymerase II. Localizes to nucleus and transcription regulator complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; hemolymphoid system; and sensory organ. Human ortholog(s) of this gene implicated in acute myeloid leukemia; immunodeficiency 21; mental depression; myelodysplastic syndrome; and myeloid leukemia. Orthologous to human GATA2 (GATA binding protein 2); PARTICIPATES IN hypoxia inducible factor pathway; INTERACTS WITH 1,1-dichloroethene; 1,2-dimethylhydrazine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: endothelial transcription factor GATA-2; Gata; Gata-2; GATA-binding protein 2; MGC129339
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39688,170,873 - 88,184,014 (+)NCBIGRCm39mm39
GRCm39 Ensembl688,170,873 - 88,184,014 (+)Ensembl
GRCm38688,193,891 - 88,207,032 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl688,193,891 - 88,207,032 (+)EnsemblGRCm38mm10GRCm38
MGSCv37688,148,658 - 88,157,026 (+)NCBIGRCm37mm9NCBIm37
MGSCv36688,164,309 - 88,172,670 (+)NCBImm8
Celera690,136,051 - 90,144,243 (+)NCBICelera
Cytogenetic Map6D1NCBI
cM Map639.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
5-fluorouracil  (ISO)
aflatoxin B2  (ISO)
all-trans-retinoic acid  (EXP,ISO)
aluminium sulfate (anhydrous)  (ISO)
amiodarone  (ISO)
ammonium chloride  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
arsenous acid  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
butanal  (ISO)
butyric acid  (ISO)
calcitriol  (ISO)
carbon nanotube  (EXP)
Chebulinic acid  (ISO)
chloroprene  (EXP)
chlorpyrifos  (ISO)
choline  (EXP)
chrysene  (EXP)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
curcumin  (ISO)
cypermethrin  (ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (EXP)
dicrotophos  (ISO)
digitonin  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
fluoranthene  (EXP)
folic acid  (EXP)
furan  (ISO)
hemin  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
L-methionine  (EXP)
lead diacetate  (EXP)
lipopolysaccharide  (EXP)
Manumycin A  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (ISO)
methapyrilene  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
nicotine  (ISO)
nitrofen  (ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP)
phenol  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pomalidomide  (ISO)
potassium chromate  (ISO)
progesterone  (EXP)
raloxifene  (ISO)
SB 203580  (EXP)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
tamibarotene  (ISO)
tamoxifen  (EXP,ISO)
Tellimagrandin I  (ISO)
tetracycline  (EXP)
tetraphene  (EXP)
thapsigargin  (ISO)
titanium dioxide  (EXP)
toluene  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triptonide  (EXP)
troglitazone  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell differentiation  (IMP)
cell differentiation in hindbrain  (IMP)
cell fate commitment  (IBA)
cell fate determination  (IDA)
cell maturation  (IMP)
central nervous system neuron development  (IMP)
cochlea development  (ISO)
commitment of neuronal cell to specific neuron type in forebrain  (IMP)
definitive hemopoiesis  (IMP)
embryonic placenta development  (IMP)
eosinophil fate commitment  (ISO)
GABAergic neuron differentiation  (IMP)
hemopoiesis  (IEA)
homeostasis of number of cells within a tissue  (IGI,IMP)
inner ear morphogenesis  (IMP)
negative regulation of endothelial cell apoptotic process  (ISO)
negative regulation of fat cell differentiation  (IMP,ISO)
negative regulation of fat cell proliferation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of macrophage differentiation  (IDA)
negative regulation of myeloid cell differentiation  (IMP)
negative regulation of neural precursor cell proliferation  (IMP,ISO)
negative regulation of Notch signaling pathway  (ISO)
negative regulation of transcription by RNA polymerase II  (IDA)
neuron differentiation  (IMP)
neuron fate commitment  (IMP)
neuron migration  (ISO)
phagocytosis  (IEA)
pituitary gland development  (IMP)
positive regulation of angiogenesis  (IBA,IMP,ISO)
positive regulation of blood vessel endothelial cell migration  (ISO)
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (ISO)
positive regulation of cell migration involved in sprouting angiogenesis  (ISO)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of erythrocyte differentiation  (IDA)
positive regulation of gene expression  (ISO)
positive regulation of mast cell degranulation  (ISO)
positive regulation of megakaryocyte differentiation  (IDA)
positive regulation of neuron differentiation  (ISO)
positive regulation of phagocytosis  (ISO)
positive regulation of phagocytosis, engulfment  (ISO)
positive regulation of pri-miRNA transcription by RNA polymerase II  (IBA,ISO)
positive regulation of transcription by RNA polymerase II  (IDA,IGI,IMP,ISO)
regulation of forebrain neuron differentiation  (IMP)
regulation of histone acetylation  (IDA)
regulation of primitive erythrocyte differentiation  (IGI)
regulation of transcription by RNA polymerase II  (IBA)
regulation of transcription, DNA-templated  (IEA)
response to lipid  (ISO)
semicircular canal development  (IMP)
somatic stem cell population maintenance  (IMP)
urogenital system development  (IMP)
vascular wound healing  (ISO)
ventral spinal cord interneuron differentiation  (IMP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal auditory brainstem response  (IEA)
abnormal blood cell morphology/development  (IAGP)
abnormal blood vessel endothelium morphology  (IAGP)
abnormal definitive hematopoiesis  (IAGP)
abnormal embryonic hematopoiesis  (IAGP)
abnormal epididymis morphology  (IEA)
abnormal erythropoiesis  (IAGP)
abnormal GABAergic neuron morphology  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal megakaryocyte progenitor cell morphology  (IAGP)
abnormal neuron differentiation  (IAGP)
abnormal ovary morphology  (IEA)
abnormal pituitary gland development  (IAGP)
abnormal pituitary secretion  (IAGP)
abnormal renal/urinary system morphology  (IAGP)
abnormal serotonergic neuron morphology  (IAGP)
abnormal ureter development  (IAGP)
abnormal ureter morphology  (IAGP)
absent epididymis  (IEA)
absent vitelline blood vessels  (IAGP)
anemia  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased circulating follicle stimulating hormone level  (IAGP)
decreased circulating thyroid-stimulating hormone level  (IAGP)
decreased common myeloid progenitor cell number  (IAGP)
decreased erythroid progenitor cell number  (IAGP)
decreased hematopoietic stem cell number  (IAGP)
decreased seminal vesicle weight  (IAGP)
decreased survivor rate  (IAGP)
edema  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
enlarged epididymis  (IEA)
enlarged pericardium  (IAGP)
hemorrhage  (IAGP)
hydronephrosis  (IAGP)
impaired hematopoiesis  (IAGP)
increased erythroid progenitor cell number  (IAGP)
increased prepulse inhibition  (IEA)
increased vascular permeability  (IAGP)
large ureter  (IAGP)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
liver hypoplasia  (IAGP)
no abnormal phenotype detected  (IAGP)
pale yolk sac  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
preweaning lethality, complete penetrance  (IEA)
renal hypoplasia  (IAGP)
small liver  (IAGP)
References

References - curated
1. Barbieri AM, etal., Proc Natl Acad Sci U S A 1999 Sep 14;96(19):10729-34.
2. Celton M, etal., Leukemia. 2014 Aug;28(8):1617-26. doi: 10.1038/leu.2014.67. Epub 2014 Feb 11.
3. Choi M, etal., PLoS One. 2014 Oct 23;9(10):e109253. doi: 10.1371/journal.pone.0109253. eCollection 2014.
4. Fadilah SA, etal., Leukemia. 2002 Aug;16(8):1563-5.
5. Fujimaki S, etal., Br J Haematol. 2001 Apr;113(1):52-7.
6. Hou HA, etal., Ann Hematol. 2015 Feb;94(2):211-21. doi: 10.1007/s00277-014-2208-8. Epub 2014 Sep 21.
7. Hsu AP, etal., Blood. 2011 Sep 8;118(10):2653-5. doi: 10.1182/blood-2011-05-356352. Epub 2011 Jun 13.
8. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
9. Lim KC, etal., J Clin Invest. 2012 Oct;122(10):3705-17. doi: 10.1172/JCI61619. Epub 2012 Sep 10.
10. Luesink M, etal., Blood. 2012 Sep 6;120(10):2064-75. doi: 10.1182/blood-2011-12-397083. Epub 2012 Jul 11.
11. MGD and Homologene mouse data transfer
12. MGD data from the GO Consortium
13. MGD IEA
14. OMIM Disease Annotation Pipeline
15. Parganas E, etal., Cell 1998 May 1;93(3):385-95.
16. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
17. RGD automated import pipeline
18. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. RGD automated import pipeline for gene-chemical interactions
20. Tang X, etal., Biotechniques. 2006 Jun;40(6):759-63.
21. Zhang SJ, etal., Leuk Res. 2009 Aug;33(8):1141-3. doi: 10.1016/j.leukres.2009.02.025. Epub 2009 Mar 21.
Additional References at PubMed
PMID:1419907   PMID:1744088   PMID:7624372   PMID:7720565   PMID:7926723   PMID:8078582   PMID:8562971   PMID:8777716   PMID:8799165   PMID:8889548   PMID:9021157   PMID:9028937  
PMID:9043071   PMID:9159135   PMID:9160668   PMID:9305891   PMID:9324354   PMID:9452491   PMID:9620855   PMID:9680380   PMID:9769172   PMID:9790776   PMID:9811459   PMID:9822612  
PMID:10198162   PMID:10208738   PMID:10349636   PMID:10357893   PMID:10361117   PMID:10367888   PMID:10402672   PMID:10447238   PMID:10499586   PMID:10556076   PMID:10588713   PMID:10662546  
PMID:10922068   PMID:10934027   PMID:11042159   PMID:11076861   PMID:11152636   PMID:11420609   PMID:11447259   PMID:11724781   PMID:11804789   PMID:11807026   PMID:11956331   PMID:12023274  
PMID:12041667   PMID:12045236   PMID:12065417   PMID:12065419   PMID:12077323   PMID:12100886   PMID:12112475   PMID:12385825   PMID:12393444   PMID:12466851   PMID:12477932   PMID:12689939  
PMID:12857954   PMID:12885554   PMID:14504093   PMID:14522873   PMID:14534138   PMID:14681479   PMID:14973276   PMID:15133515   PMID:15215894   PMID:15254248   PMID:15329349   PMID:15466621  
PMID:15494394   PMID:15499560   PMID:15533830   PMID:15542836   PMID:15618518   PMID:15673499   PMID:15689374   PMID:15737933   PMID:15739164   PMID:15811962   PMID:15837948   PMID:15889140  
PMID:15929941   PMID:16020526   PMID:16055713   PMID:16082385   PMID:16141072   PMID:16141073   PMID:16151640   PMID:16254139   PMID:16292344   PMID:16384867   PMID:16396960   PMID:16461905  
PMID:16543408   PMID:16571633   PMID:16621992   PMID:16628252   PMID:16672344   PMID:16840533   PMID:16887115   PMID:17119020   PMID:17131407   PMID:17166922   PMID:17255359   PMID:17277741  
PMID:17327407   PMID:17347142   PMID:17359917   PMID:17374603   PMID:17395646   PMID:17431131   PMID:17476283   PMID:17531968   PMID:17535249   PMID:17537790   PMID:17823307   PMID:17922007  
PMID:17950250   PMID:17962413   PMID:18154321   PMID:18184866   PMID:18202227   PMID:18211891   PMID:18212046   PMID:18233958   PMID:18243117   PMID:18246306   PMID:18287559   PMID:18299398  
PMID:18495683   PMID:18528438   PMID:18653622   PMID:18684862   PMID:18755693   PMID:18779319   PMID:18799693   PMID:18805961   PMID:18840712   PMID:19036901   PMID:19036967   PMID:19075112  
PMID:19088086   PMID:19106099   PMID:19120268   PMID:19136559   PMID:19208226   PMID:19242469   PMID:19323994   PMID:19371385   PMID:19491391   PMID:19528235   PMID:19542360   PMID:19607821  
PMID:19620289   PMID:19666821   PMID:19801444   PMID:20059953   PMID:20412781   PMID:20417196   PMID:20457756   PMID:20554972   PMID:20652952   PMID:20660741   PMID:20806357   PMID:20808444  
PMID:20818386   PMID:20833840   PMID:20838598   PMID:20887958   PMID:20934421   PMID:21245044   PMID:21246650   PMID:21267068   PMID:21320481   PMID:21321116   PMID:21345367   PMID:21356387  
PMID:21398579   PMID:21472823   PMID:21677750   PMID:21731673   PMID:21775418   PMID:21873635   PMID:21905163   PMID:21911838   PMID:21925604   PMID:21943603   PMID:21947280   PMID:22219353  
PMID:22278924   PMID:22315408   PMID:22325351   PMID:22383799   PMID:22390417   PMID:22476030   PMID:22493062   PMID:22499991   PMID:22535663   PMID:22541434   PMID:22627282   PMID:22745311  
PMID:22844247   PMID:22988301   PMID:22988430   PMID:22991444   PMID:22996659   PMID:23065276   PMID:23122290   PMID:23322776   PMID:23329048   PMID:23334579   PMID:23408898   PMID:23475960  
PMID:23524953   PMID:23536097   PMID:23592430   PMID:23614009   PMID:23637192   PMID:23648511   PMID:23674600   PMID:23732910   PMID:23840778   PMID:23892628   PMID:23911012   PMID:23940812  
PMID:24146773   PMID:24167708   PMID:24194600   PMID:24244860   PMID:24257627   PMID:24297994   PMID:24297996   PMID:24335253   PMID:24415953   PMID:24553180   PMID:24583263   PMID:24615013  
PMID:24616499   PMID:24636993   PMID:24698273   PMID:24807155   PMID:24952961   PMID:25139858   PMID:25150255   PMID:25179941   PMID:25305367   PMID:25369423   PMID:25392491   PMID:25398936  
PMID:25512300   PMID:25516969   PMID:25535330   PMID:25670854   PMID:25801432   PMID:25848090   PMID:25855601   PMID:25870109   PMID:25870111   PMID:25907033   PMID:25993409   PMID:26073540  
PMID:26124638   PMID:26147683   PMID:26166573   PMID:26187199   PMID:26204127   PMID:26214525   PMID:26542011   PMID:26601269   PMID:26660446   PMID:26718003   PMID:26812161   PMID:26834239  
PMID:26839365   PMID:26876150   PMID:27131743   PMID:27133822   PMID:27239041   PMID:27259979   PMID:27313318   PMID:27321927   PMID:27374105   PMID:27443289   PMID:27543859   PMID:27570068  
PMID:27681176   PMID:27693352   PMID:27780851   PMID:27783953   PMID:27789623   PMID:27929058   PMID:28082412   PMID:28219675   PMID:28232602   PMID:28334937   PMID:28569748   PMID:28630119  
PMID:28685891   PMID:28743859   PMID:28787589   PMID:28807932   PMID:28866324   PMID:28930689   PMID:28943250   PMID:29035278   PMID:29197504   PMID:29217535   PMID:29277702   PMID:29581184  
PMID:29666442   PMID:29689292   PMID:29773646   PMID:30010246   PMID:30044048   PMID:30088690   PMID:30615908   PMID:30620726   PMID:30635555   PMID:30710465   PMID:30916783   PMID:31112136  
PMID:31378673   PMID:31409672   PMID:31461644   PMID:31461654   PMID:31501274   PMID:31582413   PMID:31619968   PMID:31624376   PMID:31710307   PMID:31729420   PMID:31913463   PMID:32492250  
PMID:32513715   PMID:32562431   PMID:33046550   PMID:33060128   PMID:33479210  


Genomics

Comparative Map Data
Gata2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39688,170,873 - 88,184,014 (+)NCBIGRCm39mm39
GRCm39 Ensembl688,170,873 - 88,184,014 (+)Ensembl
GRCm38688,193,891 - 88,207,032 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl688,193,891 - 88,207,032 (+)EnsemblGRCm38mm10GRCm38
MGSCv37688,148,658 - 88,157,026 (+)NCBIGRCm37mm9NCBIm37
MGSCv36688,164,309 - 88,172,670 (+)NCBImm8
Celera690,136,051 - 90,144,243 (+)NCBICelera
Cytogenetic Map6D1NCBI
cM Map639.2NCBI
GATA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3128,479,427 - 128,493,185 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl3128,479,427 - 128,493,201 (-)EnsemblGRCh38hg38GRCh38
GRCh383128,479,422 - 128,493,201 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373128,198,265 - 128,212,044 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363129,680,960 - 129,694,718 (-)NCBINCBI36hg18NCBI36
Build 343129,680,969 - 129,694,726NCBI
Celera3126,626,234 - 126,639,997 (-)NCBI
Cytogenetic Map3q21.3NCBI
HuRef3125,582,307 - 125,596,070 (-)NCBIHuRef
CHM1_13128,161,207 - 128,175,078 (-)NCBICHM1_1
Gata2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24120,654,205 - 120,667,763 (+)NCBI
Rnor_6.0 Ensembl4120,133,713 - 120,142,488 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.04120,129,028 - 120,142,490 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04185,369,926 - 185,383,944 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44122,279,753 - 122,288,528 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14122,524,233 - 122,533,009 (+)NCBI
Celera4109,615,354 - 109,624,129 (+)NCBICelera
Cytogenetic Map4q34NCBI
Gata2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542915,327,113 - 15,336,460 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542915,326,551 - 15,334,774 (+)NCBIChiLan1.0ChiLan1.0
GATA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13132,890,508 - 132,899,035 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3132,890,508 - 132,899,035 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03125,526,537 - 125,535,649 (-)NCBIMhudiblu_PPA_v0panPan3
GATA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1202,472,251 - 2,488,380 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl202,473,912 - 2,480,991 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha202,508,307 - 2,517,105 (-)NCBI
ROS_Cfam_1.0202,492,701 - 2,501,504 (-)NCBI
UMICH_Zoey_3.1202,213,473 - 2,222,266 (-)NCBI
UNSW_CanFamBas_1.0202,540,074 - 2,548,847 (-)NCBI
UU_Cfam_GSD_1.0202,500,417 - 2,509,217 (-)NCBI
Gata2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494220,364,390 - 20,372,921 (+)NCBI
SpeTri2.0NW_004936798406,258 - 414,785 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GATA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1371,984,063 - 71,997,622 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11371,981,139 - 71,997,626 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21379,606,930 - 79,613,715 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GATA2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12252,549,112 - 52,562,911 (+)NCBI
ChlSab1.1 Ensembl2252,555,738 - 52,562,909 (+)Ensembl
Gata2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624961147,685 - 155,614 (+)NCBI

Position Markers
Gata2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38688,205,565 - 88,206,528UniSTSGRCm38
MGSCv37688,155,559 - 88,156,522UniSTSGRCm37
Celera690,142,776 - 90,143,739UniSTS
Cytogenetic Map6D1UniSTS
cM Map638.5UniSTS
cM Map638.5UniSTS
AB000096  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38688,206,783 - 88,206,873UniSTSGRCm38
MGSCv37688,156,777 - 88,156,867UniSTSGRCm37
Celera690,143,994 - 90,144,084UniSTS
Cytogenetic Map6D1UniSTS
cM Map638.5UniSTS
Whitehead/MRC_RH6909.82UniSTS
PMC123124P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38688,201,295 - 88,201,707UniSTSGRCm38
MGSCv37688,151,289 - 88,151,701UniSTSGRCm37
Celera690,138,736 - 90,139,148UniSTS
Cytogenetic Map6D1UniSTS
cM Map638.5UniSTS
PMC58532P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38688,204,597 - 88,205,326UniSTSGRCm38
MGSCv37688,154,591 - 88,155,320UniSTSGRCm37
Celera690,141,808 - 90,142,537UniSTS
Cytogenetic Map6D1UniSTS
cM Map638.5UniSTS
Gata2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38688,205,212 - 88,205,331UniSTSGRCm38
MGSCv37688,155,206 - 88,155,325UniSTSGRCm37
Celera690,142,423 - 90,142,542UniSTS
Cytogenetic Map6D1UniSTS
Gata2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38688,193,244 - 88,193,426UniSTSGRCm38
MGSCv37688,143,238 - 88,143,420UniSTSGRCm37
Celera690,130,631 - 90,130,813UniSTS
Cytogenetic Map6D1UniSTS
Gata2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6D1UniSTS
cM Map638.5UniSTS
Gata2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38688,198,759 - 88,199,676UniSTSGRCm38
MGSCv37688,148,753 - 88,149,670UniSTSGRCm37
Cytogenetic Map6D1UniSTS
Gata2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6D1UniSTS
Gata2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6D1UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25440480Moaq2_mmodifier of alien QTL 2 (mouse)61117500000Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139100000Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396656149Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396656149Mouse
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396656149Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396656149Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63866962592607450Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645314059128835032Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46935985136423692Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648720000125360000Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648720000148450000Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648726556125356785Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652161713116155267Mouse
4141028Mclr_mmethylcholanthrene lymphoma resistance (mouse)Not determined5437342788379171Mouse
15039373Adip28_madiposity 28 (mouse)65630821190308211Mouse
15039375Bw41_mbody weight QTL 41 (mouse)65630821190308211Mouse
1558977Skmw10_mskeletal muscle weight 10 (mouse)Not determined65844758392447710Mouse
10043972Obq28_mobesity QTL 28 (mouse)Not determined65854043392540433Mouse
1301740Bwq2_mbody weight QTL 2 (mouse)Not determined66005768094057799Mouse
1301369Im4_mimmunoregulatory 4 (mouse)Not determined66348473897484905Mouse
1300650Bw18_mbody weight QTL 18 (mouse)Not determined666713869100714031Mouse
1301876Bits2_mbitterness sensitivity 2 (mouse)Not determined670425898104426034Mouse
1301813Skl3_mskeletal size (tail length) 3 (mouse)Not determined670425898104426034Mouse
1301034Egrm2_mearly growth rate (mouse)Not determined670425898104426034Mouse
1302020Bbaa20_mB.burgdorferi-associated arthritis 20 (mouse)Not determined67132262193464093Mouse
1300869Stheal5_msoft tissue heal 5 (mouse)Not determined671575060105575178Mouse
1300954Fcsa1_mfemoral cross-sectional area 1 (mouse)Not determined671981024105981170Mouse
1301521Pas1c_mpulmonary adenoma susceptibility 1c (mouse)Not determined671981024105981170Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673500000134700000Mouse
1301320Ots1_movarian teratoma susceptibility 1 (mouse)Not determined675447583104503555Mouse
1301571Arrd1_mage-related retinal degeneration 1 (mouse)Not determined67554435692607450Mouse
1300674Nidd3n_mnon-insulin-dependent diabetes mellitus 3 in NSY (mouse)Not determined67554435694225955Mouse
10412195Efw_mepididymal fat weight (mouse)Not determined67554435694225955Mouse
10043901Pfat5_mpredicted fat percentage 5 (mouse)Not determined675607306109607450Mouse
10412208Cypr4_mcytokine production 4 (mouse)Not determined675716503109716697Mouse
1357875Pfat2_mpredicted fat percentage 2 (mouse)Not determined676463949110464093Mouse
14697704Stsl4_mSalmonella typhimurium susceptibility locus 4 (mouse)67710000090000000Mouse
13824985Alh1_mamplitude of lateral head displacement 1 (mouse)67800000097000000Mouse
4141376Dbm1_mdiabetes modifier 1 (mouse)Not determined678629504121115387Mouse
14696731Pairq1_mP. aeruginosa infection resistance QTL 1 (mouse)681500000102200000Mouse
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683713869147052561Mouse
11251720Ewc4_methanol withdrawal and consumption 4 (mouse)684122513118122513Mouse
1301687Mnic2_mmacronutrient intake (mouse)Not determined686806805113544602Mouse
1301744Hdlq11_mHDL QTL 11 (mouse)Not determined687503360121503555Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:972
Count of miRNA genes:363
Interacting mature miRNAs:412
Transcripts:ENSMUST00000015197, ENSMUST00000170089
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000015197   ⟹   ENSMUSP00000015197
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl688,198,334 - 88,207,030 (+)Ensembl
RefSeq Acc Id: ENSMUST00000170089   ⟹   ENSMUSP00000128198
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl688,193,891 - 88,207,032 (+)Ensembl
RefSeq Acc Id: ENSMUST00000203480   ⟹   ENSMUSP00000145503
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl688,198,334 - 88,199,663 (+)Ensembl
RefSeq Acc Id: ENSMUST00000203579
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl688,204,445 - 88,205,771 (+)Ensembl
RefSeq Acc Id: ENSMUST00000205151
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl688,200,919 - 88,202,641 (+)Ensembl
RefSeq Acc Id: NM_001355253   ⟹   NP_001342182
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39688,170,873 - 88,184,014 (+)NCBI
GRCm38688,193,891 - 88,207,032 (+)NCBI
Sequence:
RefSeq Acc Id: NM_008090   ⟹   NP_032116
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39688,175,646 - 88,184,014 (+)NCBI
GRCm38688,198,664 - 88,207,032 (+)NCBI
MGSCv37688,148,658 - 88,157,026 (+)RGD
Celera690,136,051 - 90,144,243 (+)RGD
cM Map6 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_032116   ⟸   NM_008090
- UniProtKB: O09100 (UniProtKB/Swiss-Prot),   Q3U320 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001342182   ⟸   NM_001355253
RefSeq Acc Id: ENSMUSP00000128198   ⟸   ENSMUST00000170089
RefSeq Acc Id: ENSMUSP00000145503   ⟸   ENSMUST00000203480
RefSeq Acc Id: ENSMUSP00000015197   ⟸   ENSMUST00000015197
Protein Domains
GATA-type

Promoters
RGD ID:6839333
Promoter ID:MM_KWN:46812
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Lung
Transcripts:UC009CVC.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36688,143,516 - 88,144,016 (+)MPROMDB
RGD ID:6839331
Promoter ID:MM_KWN:46813
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000015197
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36688,148,501 - 88,149,001 (+)MPROMDB
RGD ID:6847997
Promoter ID:MM_ACW:41927
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Lung
Transcripts:GATA2.CSEP07,   GATA2.DSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36688,154,511 - 88,155,011 (+)MPROMDB
RGD ID:6890366
Promoter ID:EPDNEW_M8634
Type:multiple initiation site
Name:Gata2_1
Description:Mus musculus GATA binding protein 2 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38688,198,668 - 88,198,728EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:95662 AgrOrtholog
Ensembl Genes ENSMUSG00000015053 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000015197 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000128198 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000145503 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000015197 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000170089 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000203480 UniProtKB/TrEMBL
Gene3D-CATH 3.30.50.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GATA-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TF_GATA-2/3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transcription_factor_GATA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_GATA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_NHR/GATA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:14461 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:95662 ENTREZGENE
NCBI Gene 14461 ENTREZGENE
PANTHER PTHR10071 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10071:SF149 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GATA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gata2 PhenoGen
PIRSF TF_GATA-1/2/3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS GATAZNFINGER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GATA_ZN_FINGER_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GATA_ZN_FINGER_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ZnF_GATA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0N4SWF9_MOUSE UniProtKB/TrEMBL
  GATA2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3B845_MOUSE UniProtKB/TrEMBL
  Q3U320 ENTREZGENE, UniProtKB/TrEMBL
  Q9DBY9_MOUSE UniProtKB/TrEMBL
  Q9DC59_MOUSE UniProtKB/TrEMBL