Acvr2b (activin receptor IIB) - Rat Genome Database
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Pathways
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Gene: Acvr2b (activin receptor IIB) Mus musculus
Analyze
Symbol: Acvr2b
Name: activin receptor IIB
RGD ID: 10078
MGI Page MGI
Description: Exhibits activin binding activity; growth factor binding activity; and protein kinase activity. Involved in several processes, including animal organ development; circulatory system development; and embryonic morphogenesis. Predicted to localize to activin receptor complex and cytoplasm. Is expressed in several structures, including alimentary system; egg cylinder; genitourinary system; nervous system; and sensory organ. Used to study right atrial isomerism and visceral heterotaxy. Human ortholog(s) of this gene implicated in visceral heterotaxy. Orthologous to human ACVR2B (activin A receptor type 2B); PARTICIPATES IN activin signaling pathway; transforming growth factor-beta superfamily mediated signaling pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 4930516B21Rik; AA432611; Act; activin receptor type IIB; activin receptor type-2B; ACTR-IIB; ActRIIB; AI047905; AI850658; hypothetical protein LOC75114; MGC118477; RIKEN cDNA 4930516B21 gene; uncharacterized protein LOC75114
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399119,231,081 - 119,271,214 (+)NCBIGRCm39mm39
GRCm389119,401,583 - 119,442,148 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9119,402,118 - 119,434,995 (+)EnsemblGRCm38mm10GRCm38
MGSCv379119,311,619 - 119,342,633 (+)NCBIGRCm37mm9NCBIm37
MGSCv369119,251,199 - 119,282,213 (+)NCBImm8
Celera9119,872,378 - 119,903,791 (+)NCBICelera
Cytogenetic Map9F3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase activity  (IDA)
activin receptor signaling pathway  (IBA,ISO)
adrenal gland development  (ISO)
anterior/posterior pattern specification  (IGI,IMP,ISO)
artery development  (IMP)
blood vessel remodeling  (IMP)
BMP signaling pathway  (ISO)
cellular response to growth factor stimulus  (IBA)
determination of left/right symmetry  (IGI,IMP)
embryonic foregut morphogenesis  (IMP)
gastrulation with mouth forming second  (IGI)
heart development  (IGI,IMP)
insulin secretion  (IGI)
kidney development  (IGI,IMP)
lung development  (IGI)
lymphangiogenesis  (IMP)
lymphatic endothelial cell differentiation  (IMP)
mesoderm development  (IGI)
negative regulation of cold-induced thermogenesis  (IMP)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of transforming growth factor beta activation  (ISO)
odontogenesis of dentin-containing tooth  (IGI,IMP)
organ growth  (IGI)
pancreas development  (IGI)
pattern specification process  (IGI)
phosphorylation  (IEA)
positive regulation of activin receptor signaling pathway  (ISO)
positive regulation of bone mineralization  (ISO)
positive regulation of osteoblast differentiation  (ISO)
post-embryonic development  (IGI,IMP)
protein phosphorylation  (IBA)
regulation of signal transduction  (IDA)
regulation of transcription, DNA-templated  (ISO)
response to glucose  (IGI)
retina vasculature development in camera-type eye  (IMP)
roof of mouth development  (IGI,IMP)
signal transduction  (ISO)
skeletal system development  (IGI,IMP)
skeletal system morphogenesis  (IGI,IMP)
transmembrane receptor protein serine/threonine kinase signaling pathway  (IEA)
venous blood vessel development  (IMP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal bronchus morphology  (IAGP)
abnormal cardiac outflow tract development  (IAGP)
abnormal direction of heart looping  (IAGP)
abnormal embryo size  (IEA)
abnormal embryonic tissue morphology  (IAGP)
abnormal eye morphology  (IEA)
abnormal gastrulation  (IAGP)
abnormal heart development  (IAGP)
abnormal heart position or orientation  (IAGP)
abnormal hindbrain morphology  (IEA)
abnormal left-right axis patterning  (IAGP)
abnormal liver morphology  (IAGP)
abnormal mesoderm development  (IAGP)
abnormal neural tube closure  (IEA)
abnormal primitive streak elongation  (IAGP)
abnormal rib morphology  (IAGP)
abnormal rostral-caudal axis patterning  (IAGP)
abnormal spleen morphology  (IAGP)
absent allantois  (IAGP)
absent amnion  (IAGP)
absent head fold  (IAGP)
absent heart tube  (IAGP)
absent kidney  (IAGP)
absent mesoderm  (IAGP)
atrial septal defect  (IAGP)
cyanosis  (IAGP)
decreased startle reflex  (IEA)
dextrocardia  (IAGP)
embryonic growth arrest  (IAGP)
embryonic lethality between implantation and somite formation, complete penetrance  (IAGP)
embryonic lethality between somite formation and embryo turning  (IAGP)
embryonic-extraembryonic boundary constriction  (IAGP)
failure to gastrulate  (IAGP)
increased embryonic epiblast cell apoptosis  (IAGP)
increased skeletal muscle weight  (IAGP)
increased thoracic vertebrae number  (IAGP)
lumbar vertebral transformation  (IAGP)
mesocardia  (IAGP)
pallor  (IEA)
perinatal lethality, complete penetrance  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
preweaning lethality, incomplete penetrance  (IEA)
renal hypoplasia  (IAGP)
rib fusion  (IAGP)
right atrial isomerism  (IAGP)
right pulmonary isomerism  (IAGP)
sacral vertebral transformation  (IAGP)
single kidney  (IAGP)
small spleen  (IAGP)
thoracic vertebral transformation  (IAGP)
transposition of great arteries  (IAGP)
ventricular septal defect  (IAGP)
vertebral transformation  (IAGP)
References

Additional References at PubMed
PMID:1310075   PMID:1318045   PMID:1326537   PMID:7577669   PMID:7619733   PMID:7748787   PMID:7821227   PMID:8049070   PMID:8161782   PMID:8286599   PMID:8889548   PMID:9260931  
PMID:9707328   PMID:10349636   PMID:10452853   PMID:10772805   PMID:10921901   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11459935   PMID:11714685   PMID:11882656  
PMID:12112458   PMID:12414726   PMID:12477932   PMID:12514121   PMID:12546816   PMID:12666204   PMID:12729564   PMID:14610273   PMID:14966532   PMID:15239668   PMID:15277382   PMID:15304227  
PMID:15342483   PMID:15542835   PMID:15615879   PMID:15913604   PMID:15963767   PMID:15963972   PMID:15976303   PMID:16141072   PMID:16141073   PMID:16330774   PMID:16384867   PMID:16477644  
PMID:16602821   PMID:16806156   PMID:16845371   PMID:16991118   PMID:17849440   PMID:17913787   PMID:17936261   PMID:18334608   PMID:18453534   PMID:18621057   PMID:18799693   PMID:18927151  
PMID:18973680   PMID:18974875   PMID:19148298   PMID:19153222   PMID:19653325   PMID:19716815   PMID:19903896   PMID:20801112   PMID:20856813   PMID:21267068   PMID:21281811   PMID:21503889  
PMID:21538804   PMID:21731673   PMID:21873635   PMID:22074949   PMID:22485132   PMID:22586266   PMID:22869749   PMID:23034635   PMID:23342175   PMID:24019467   PMID:24194600   PMID:24726641  
PMID:24859004   PMID:24917498   PMID:24952961   PMID:26083127   PMID:27030100   PMID:27554968   PMID:27626380   PMID:27897407   PMID:28324027   PMID:28659341   PMID:28844842   PMID:29688375  
PMID:31311865   PMID:31419601   PMID:31666509   PMID:32270195   PMID:32325033  


Genomics

Comparative Map Data
Acvr2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399119,231,081 - 119,271,214 (+)NCBIGRCm39mm39
GRCm389119,401,583 - 119,442,148 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9119,402,118 - 119,434,995 (+)EnsemblGRCm38mm10GRCm38
MGSCv379119,311,619 - 119,342,633 (+)NCBIGRCm37mm9NCBIm37
MGSCv369119,251,199 - 119,282,213 (+)NCBImm8
Celera9119,872,378 - 119,903,791 (+)NCBICelera
Cytogenetic Map9F3NCBI
ACVR2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl338,453,890 - 38,493,142 (+)EnsemblGRCh38hg38GRCh38
GRCh38338,453,890 - 38,493,142 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37338,495,790 - 38,534,633 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36338,470,794 - 38,509,637 (+)NCBINCBI36hg18NCBI36
Build 34338,470,813 - 38,499,868NCBI
Celera338,431,705 - 38,470,515 (+)NCBI
Cytogenetic Map3p22.2NCBI
HuRef338,561,058 - 38,576,879 (+)NCBIHuRef
CHM1_1338,447,458 - 38,486,272 (+)NCBICHM1_1
Acvr2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08128,087,308 - 128,126,776 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8128,087,345 - 128,118,746 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08127,294,071 - 127,331,625 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48124,364,330 - 124,395,748 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18124,383,832 - 124,415,475 (+)NCBI
Celera8118,290,038 - 118,321,362 (+)NCBICelera
Cytogenetic Map8q32NCBI
Acvr2b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542725,438,652 - 25,467,360 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542725,438,652 - 25,467,360 (-)NCBIChiLan1.0ChiLan1.0
ACVR2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1338,633,097 - 38,671,843 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl338,633,093 - 38,662,063 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0338,350,838 - 38,389,839 (+)NCBIMhudiblu_PPA_v0panPan3
ACVR2B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl238,192,483 - 8,218,894 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1238,211,555 - 8,225,596 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Acvr2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493647327,816,366 - 27,822,555 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACVR2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1323,237,699 - 23,267,382 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11323,237,699 - 23,276,086 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21325,422,228 - 25,450,766 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ACVR2B
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.115923,222 - 962,438 (-)NCBI
Acvr2b
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247312,557,993 - 2,600,250 (-)NCBI

Position Markers
Acvr2b  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389119,428,714 - 119,429,693UniSTSGRCm38
MGSCv379119,337,832 - 119,338,811UniSTSGRCm37
Celera9119,898,562 - 119,899,539UniSTS
Cytogenetic Map9F3UniSTS
cM Map9 UniSTS
MARC_4816-4817:991938566:3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389119,429,869 - 119,430,257UniSTSGRCm38
MGSCv379119,338,987 - 119,339,375UniSTSGRCm37
Celera9119,899,715 - 119,900,103UniSTS
Cytogenetic Map9F3UniSTS
PMC202382P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389119,432,719 - 119,432,840UniSTSGRCm38
MGSCv379119,341,837 - 119,341,958UniSTSGRCm37
Celera9119,902,995 - 119,903,116UniSTS
Cytogenetic Map9F3UniSTS
Acvr2b  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9F3UniSTS
Cytogenetic Map2C1.1UniSTS
cM Map9 UniSTS
Acvr2b  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389119,432,532 - 119,433,446UniSTSGRCm38
MGSCv379119,341,650 - 119,342,564UniSTSGRCm37
Celera9119,902,808 - 119,903,722UniSTS
Cytogenetic Map9F3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63332429120362868Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63332429120362868Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963332429120362868Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986230401120230530Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986239845120289624Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986748483120748483Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987800000121800000Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989284925123284925Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989412277123412396Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989563342123563342Mouse
12910770Splic1_mspleen iron content 1 (mouse)991413879124595110Mouse
12910772Lvic6_mliver iron content 6 (mouse)991413879124595110Mouse
12910773Splic3_mspleen iron content 3 (mouse)991413879124595110Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991641084124595110Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991641084124595110Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991641084124595110Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991641084124595110Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991641084124595110Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991641084124595110Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991683173124595110Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991683173124595110Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991683173124595110Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993762590124595110Mouse
1301484Bwq6_mbody weight (mouse)Not determined993762590124595110Mouse
14746992Manh67_mmandible shape 67 (mouse)994036768124595110Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996917590124595110Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9101060861124595110Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9102000187124595110Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9102000187124595110Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103289445124595110Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103289445124595110Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103289445124595110Mouse

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir141mmu-miR-141-3pOncomiRDBexternal_infoNANA22431721
Mir215mmu-miR-215-5pOncomiRDBexternal_infoNANA22431721
Mir194-1mmu-miR-194-5pOncomiRDBexternal_infoNANA22431721
Mir200cmmu-miR-200c-3pOncomiRDBexternal_infoNANA22431721
Mir194-2mmu-miR-194-5pOncomiRDBexternal_infoNANA22431721
Mir192mmu-miR-192-5pOncomiRDBexternal_infoNANA22431721

Predicted Target Of
Summary Value
Count of predictions:202
Count of miRNA genes:88
Interacting mature miRNAs:92
Transcripts:ENSMUST00000035093, ENSMUST00000165044
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001313757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_007397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006511926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030244026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036154567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036154568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036154569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004935309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA432611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC166052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI850658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK135803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK137432 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB700113 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC106189 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M84119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M84120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000035093   ⟹   ENSMUSP00000035093
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9119,402,444 - 119,433,501 (+)Ensembl
RefSeq Acc Id: ENSMUST00000165044   ⟹   ENSMUSP00000126108
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9119,402,118 - 119,433,515 (+)Ensembl
RefSeq Acc Id: ENSMUST00000213389
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9119,432,410 - 119,433,461 (+)Ensembl
RefSeq Acc Id: ENSMUST00000213431
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9119,432,438 - 119,433,374 (+)Ensembl
RefSeq Acc Id: ENSMUST00000215746   ⟹   ENSMUSP00000150566
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9119,402,444 - 119,434,995 (+)Ensembl
RefSeq Acc Id: ENSMUST00000217621
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9119,430,346 - 119,433,034 (+)Ensembl
RefSeq Acc Id: NM_001313757   ⟹   NP_001300686
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399119,231,244 - 119,271,214 (+)NCBI
GRCm389119,402,178 - 119,442,148 (+)NCBI
Sequence:
RefSeq Acc Id: NM_007397   ⟹   NP_031423
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399119,231,244 - 119,271,214 (+)NCBI
GRCm389119,402,178 - 119,442,148 (+)NCBI
MGSCv379119,311,619 - 119,342,633 (+)RGD
Celera9119,872,380 - 119,903,791 (+)ENTREZGENE
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006511926   ⟹   XP_006511989
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399119,231,081 - 119,271,200 (+)NCBI
GRCm389119,401,583 - 119,442,134 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030244026   ⟹   XP_030099886
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399119,231,718 - 119,271,200 (+)NCBI
GRCm389119,402,650 - 119,442,134 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036154567   ⟹   XP_036010460
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399119,236,071 - 119,271,200 (+)NCBI
RefSeq Acc Id: XM_036154568   ⟹   XP_036010461
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399119,236,072 - 119,271,200 (+)NCBI
RefSeq Acc Id: XM_036154569   ⟹   XP_036010462
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399119,236,072 - 119,271,200 (+)NCBI
RefSeq Acc Id: XR_004935309
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399119,236,071 - 119,271,200 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_031423   ⟸   NM_007397
- Peptide Label: precursor
- UniProtKB: P27040 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006511989   ⟸   XM_006511926
- Peptide Label: isoform X4
- UniProtKB: P27040 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001300686   ⟸   NM_001313757
- Peptide Label: isoform 2 precursor
- UniProtKB: P27040 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_030099886   ⟸   XM_030244026
- Peptide Label: isoform X5
RefSeq Acc Id: ENSMUSP00000035093   ⟸   ENSMUST00000035093
RefSeq Acc Id: ENSMUSP00000126108   ⟸   ENSMUST00000165044
RefSeq Acc Id: ENSMUSP00000150566   ⟸   ENSMUST00000215746
RefSeq Acc Id: XP_036010460   ⟸   XM_036154567
- Peptide Label: isoform X1
RefSeq Acc Id: XP_036010461   ⟸   XM_036154568
- Peptide Label: isoform X2
RefSeq Acc Id: XP_036010462   ⟸   XM_036154569
- Peptide Label: isoform X3
Protein Domains
Protein kinase

Promoters
RGD ID:6844070
Promoter ID:MM_KWN:59135
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Liver,   Lung
Transcripts:ENSMUST00000035093,   UC009SAY.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369119,310,881 - 119,311,677 (+)MPROMDB
RGD ID:8671196
Promoter ID:EPDNEW_M13629
Type:initiation region
Name:Acvr2b_1
Description:Mus musculus activin receptor IIB , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389119,402,128 - 119,402,188EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:87912 AgrOrtholog
Ensembl Genes ENSMUSG00000061393 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000035093 UniProtKB/Swiss-Prot
  ENSMUSP00000126108 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000150566 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000035093 UniProtKB/Swiss-Prot
  ENSMUST00000165044 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000215746 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Activin_recp UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
  TGFB_receptor UniProtKB/Swiss-Prot
KEGG Report mmu:11481 UniProtKB/Swiss-Prot
MGD MGI:87912 ENTREZGENE
NCBI Gene 11481 ENTREZGENE
PANTHER PTHR23255 UniProtKB/Swiss-Prot
Pfam Activin_recp UniProtKB/Swiss-Prot
  Pkinase UniProtKB/Swiss-Prot
PharmGKB ACVR2B RGD
PhenoGen Acvr2b PhenoGen
PRINTS ACTIVIN2R UniProtKB/Swiss-Prot
PROSITE PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
UniGene Mm.390239 ENTREZGENE
  Mm.8940 ENTREZGENE
UniProt AVR2B_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q3KQI1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-05 Acvr2b  activin receptor IIB  4930516B21Rik  RIKEN cDNA 4930516B21 gene  Data Merged 737654 PROVISIONAL