Gene: Acvr2b (activin receptor IIB) Mus musculus
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Symbol:
Acvr2b
Name:
activin receptor IIB
Description:
ENCODES a protein that exhibits activin binding; growth factor binding; protein serine/threonine kinase activity; INVOLVED IN activation of protein kinase activity; anterior/posterior pattern specification; artery development; PARTICIPATES IN activin signaling pathway; transforming growth factor-beta superfamily mediated signaling pathway; ASSOCIATED WITH abnormal bronchus morphology; abnormal cardiac outflow tract development; abnormal direction of heart looping; ASSOCIATED WITH Brugada syndrome (ortholog); situs inversus (ortholog); visceral heterotaxy (ortholog); FOUND IN cytoplasm (ortholog); protein-containing complex (ortholog); receptor complex (ortholog); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,2',4,4',5,5'-hexachlorobiphenyl
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
4930516B21Rik; AA432611; activin receptor type IIB; activin receptor type-2B; ACTR-IIB; ActRIIB; AI047905; AI850658; hypothetical protein LOC75114; MGC118477; RIKEN cDNA 4930516B21 gene; uncharacterized protein LOC75114
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
ACVR2B (activin A receptor type 2B) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Acvr2b (activin A receptor type 2B) HGNC
EggNOG, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Acvr2b (activin A receptor type 2B) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
ACVR2B (activin A receptor type 2B) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
ACVR2B (activin A receptor type 2B) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Acvr2b (activin A receptor type 2B) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
ACVR2B (activin A receptor type 2B) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
ACVR2A (activin A receptor type 2A) HGNC
OrthoDB, OrthoMCL
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Acvr2b (activin A receptor type 2B)
Alliance
DIOPT (Ensembl Compara, InParanoid, OMA, OrthoFinder, PANTHER)
Homo sapiens (human):
ACVR2B (activin A receptor type 2B)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Caenorhabditis elegans (roundworm):
daf-4
Alliance
DIOPT (Hieranoid, InParanoid, OrthoInspector, PANTHER, Roundup)
Drosophila melanogaster (fruit fly):
put
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup)
Danio rerio (zebrafish):
acvr2ba
Alliance
DIOPT (Ensembl Compara, OMA, OrthoFinder, PANTHER, PhylomeDB, TreeFam, ZFIN)
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38 9 119,401,583 - 119,442,148 (+) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 9 119,311,619 - 119,342,633 (+) NCBI GRCm37 mm9 NCBIm37 MGSCv36 9 119,251,199 - 119,282,213 (+) NCBI mm8 Celera 9 119,872,380 - 119,903,791 (+) NCBI Celera Cytogenetic Map 9 F3 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
Imported Annotations - ClinVar
Brugada syndrome ISO RGD:737613 8554872 ClinVar Annotator: match by term: Brugada syndrome ClinVar PMID:28492532 Brugada syndrome ISO RGD:737613 8554872 ClinVar Annotator: match by term: Brugada syndrome ClinVar PMID:20129283 more ... visceral heterotaxy ISO RGD:737613 8554872 ClinVar Annotator: match by term: Heterotaxy syndrome ClinVar PMID:25741868 , PMID:28492532 visceral heterotaxy ISO RGD:737613 8554872 ClinVar Annotator: match by term: Heterotaxy syndrome ClinVar PMID:28492532 visceral heterotaxy ISO RGD:737613 8554872 ClinVar Annotator: match by term: Heterotaxy syndrome ClinVar PMID:25741868 more ... visceral heterotaxy ISO RGD:737613 8554872 ClinVar Annotator: match by term: Heterotaxy syndrome ClinVar PMID:24033266 , PMID:25741868 visceral heterotaxy ISO RGD:737613 8554872 ClinVar Annotator: match by term: Heterotaxy syndrome ClinVar Visceral Heterotaxy 4, Autosomal ISO RGD:737613 8554872 ClinVar Annotator: match by term: Heterotaxy, visceral, 4, autosomal ClinVar Visceral Heterotaxy 4, Autosomal ISO RGD:737613 8554872 ClinVar Annotator: match by term: Heterotaxy, visceral, 4, autosomal ClinVar PMID:25741868 more ... Visceral Heterotaxy 4, Autosomal ISO RGD:737613 8554872 ClinVar Annotator: match by term: Heterotaxy, visceral, 4, autosomal ClinVar PMID:24033266 , PMID:25741868 Visceral Heterotaxy 4, Autosomal ISO RGD:737613 8554872 ClinVar Annotator: match by OMIM:613751 ClinVar PMID:25741868 Visceral Heterotaxy 4, Autosomal ISO RGD:737613 8554872 ClinVar Annotator: match by term: Heterotaxy, visceral, 4, autosomal ClinVar PMID:25741868 , PMID:28492532 Visceral Heterotaxy 4, Autosomal ISO RGD:737613 8554872 ClinVar Annotator: match by OMIM:613751 ClinVar PMID:9916847 Visceral Heterotaxy 4, Autosomal ISO RGD:737613 8554872 ClinVar Annotator: match by term: Heterotaxy, visceral, 4, autosomal ClinVar PMID:28492532
Imported Annotations - CTD
situs inversus ISO RGD:737613 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:9916847 visceral heterotaxy ISO RGD:737613 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:9916847
Imported Annotations - MGI
right atrial isomerism IEA 13592920 OMIM:208530 MouseDO visceral heterotaxy IEA 13592920 OMIM:306955 more ... MouseDO Imported Annotations - OMIM
Visceral Heterotaxy 4, Autosomal ISO RGD:737613 7240710 OMIM
17alpha-ethynylestradiol increases expression ISO RGD:2028 6480464 Ethinyl Estradiol results in increased expression of ACVR2B mRNA CTD PMID:29097150 17beta-estradiol decreases expression ISO RGD:737613 6480464 Estradiol results in decreased expression of ACVR2B mRNA CTD PMID:14994273 17beta-estradiol decreases expression EXP 6480464 Estradiol results in decreased expression of ACVR2B mRNA CTD PMID:14994273 17beta-estradiol 3-benzoate decreases expression EXP 6480464 estradiol 3-benzoate results in decreased expression of ACVR2B mRNA CTD PMID:14994273 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions EXP 6480464 [2 more ... CTD PMID:25510870 2,2',5,5'-tetrachlorobiphenyl multiple interactions EXP 6480464 [2 more ... CTD PMID:25510870 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:737613 6480464 Tetrachlorodibenzodioxin results in increased expression of ACVR2B mRNA CTD PMID:12377990 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of ACVR2B mRNA CTD PMID:21570461 4,4'-diaminodiphenylmethane decreases expression EXP 6480464 4, 4'-diaminodiphenylmethane results in decreased expression of ACVR2B mRNA CTD PMID:18648102 6-propyl-2-thiouracil increases expression ISO RGD:2028 6480464 Propylthiouracil results in increased expression of ACVR2B mRNA CTD PMID:24780913 acrylamide decreases expression ISO RGD:2028 6480464 Acrylamide results in decreased expression of ACVR2B mRNA CTD PMID:28959563 ammonium chloride affects expression ISO RGD:2028 6480464 Ammonium Chloride affects the expression of ACVR2B mRNA CTD PMID:16483693 antirheumatic drug increases expression ISO RGD:737613 6480464 Antirheumatic Agents results in increased expression of ACVR2B mRNA CTD PMID:24449571 arsane affects expression ISO RGD:737613 6480464 Arsenic affects the expression of ACVR2B protein CTD PMID:24675094 arsenic atom affects expression ISO RGD:737613 6480464 Arsenic affects the expression of ACVR2B protein CTD PMID:24675094 arsenic(3+) affects expression ISO RGD:737613 6480464 Arsenic affects the expression of ACVR2B protein CTD PMID:24675094 bexarotene increases expression ISO RGD:2028 6480464 bexarotene results in increased expression of ACVR2B mRNA CTD PMID:16648578 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of ACVR2B mRNA CTD PMID:14994273 bisphenol A decreases methylation EXP 6480464 bisphenol A results in decreased methylation of ACVR2B promoter CTD PMID:27312807 bisphenol A increases methylation ISO RGD:2028 6480464 bisphenol A results in increased methylation of ACVR2B gene CTD PMID:28505145 bisphenol A increases expression ISO RGD:2028 6480464 bisphenol A results in increased expression of ACVR2B mRNA CTD PMID:29097150 bisphenol A affects expression ISO RGD:2028 6480464 bisphenol A affects the expression of ACVR2B mRNA CTD PMID:25181051 bisphenol A multiple interactions EXP 6480464 fulvestrant inhibits the reaction [bisphenol A results in decreased expression of ACVR2B mRNA] CTD PMID:14994273 butanal decreases expression ISO RGD:737613 6480464 butyraldehyde results in decreased expression of ACVR2B mRNA CTD PMID:26079696 cadmium sulfate increases expression EXP 6480464 cadmium sulfate results in increased expression of ACVR2B mRNA CTD PMID:19274763 carbamazepine affects expression ISO RGD:737613 6480464 Carbamazepine affects the expression of ACVR2B mRNA CTD PMID:24752500 carbon nanotube decreases expression EXP 6480464 Nanotubes, Carbon analog results in decreased expression of ACVR2B mRNA, Nanotubes, Carbon results in decreased expression of ACVR2B mRNA CTD PMID:25554681 choline multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ACVR2B gene CTD PMID:20938992 cisplatin increases expression ISO RGD:737613 6480464 Cisplatin results in increased expression of ACVR2B mRNA CTD PMID:27594783 cyclosporin A increases expression ISO RGD:737613 6480464 Cyclosporine results in increased expression of ACVR2B mRNA CTD PMID:25562108 dibenz[a,h]anthracene increases expression EXP 6480464 1 more ... CTD PMID:26377693 diclofenac affects expression ISO RGD:737613 6480464 Diclofenac affects the expression of ACVR2B mRNA CTD PMID:24752500 dorsomorphin multiple interactions ISO RGD:737613 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ACVR2B mRNA CTD PMID:27188386 endosulfan increases expression ISO RGD:2028 6480464 Endosulfan results in increased expression of ACVR2B mRNA CTD PMID:29391264 entinostat decreases expression ISO RGD:737613 6480464 entinostat results in decreased expression of ACVR2B mRNA CTD PMID:27188386 folic acid multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ACVR2B gene CTD PMID:20938992 formaldehyde increases expression ISO RGD:737613 6480464 Formaldehyde results in increased expression of ACVR2B mRNA CTD PMID:23649840 fulvestrant multiple interactions EXP 6480464 fulvestrant inhibits the reaction [bisphenol A results in decreased expression of ACVR2B mRNA] CTD PMID:14994273 L-methionine multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ACVR2B gene CTD PMID:20938992 LY294002 multiple interactions ISO RGD:737613 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of ACVR2B mRNA] CTD PMID:12710931 methyl methanesulfonate increases expression ISO RGD:737613 6480464 Methyl Methanesulfonate results in increased expression of ACVR2B mRNA CTD PMID:23649840 N-methyl-4-phenylpyridinium multiple interactions ISO RGD:737613 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of ACVR2B mRNA] CTD PMID:12710931 phenylmercury acetate decreases expression ISO RGD:737613 6480464 Phenylmercuric Acetate results in decreased expression of ACVR2B mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO RGD:737613 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ACVR2B mRNA CTD PMID:27188386 phorone affects expression ISO RGD:2028 6480464 phorone affects the expression of ACVR2B mRNA CTD PMID:18198479 progesterone affects expression EXP 6480464 Progesterone affects the expression of ACVR2B mRNA CTD PMID:17251523 propiconazole decreases expression EXP 6480464 propiconazole results in decreased expression of ACVR2B mRNA CTD PMID:21278054 retinyl acetate increases expression EXP 6480464 retinol acetate results in increased expression of ACVR2B mRNA CTD PMID:16772331 SB 431542 multiple interactions ISO RGD:737613 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ACVR2B mRNA CTD PMID:27188386 tamoxifen decreases expression EXP 6480464 Tamoxifen results in decreased expression of ACVR2B mRNA CTD PMID:25123088 testosterone enanthate affects expression ISO RGD:737613 6480464 testosterone enanthate affects the expression of ACVR2B mRNA CTD PMID:17440010 troglitazone decreases expression EXP 6480464 troglitazone results in decreased expression of ACVR2B mRNA CTD PMID:28973697 valproic acid affects expression EXP 6480464 Valproic Acid affects the expression of ACVR2B mRNA CTD PMID:17963808 valproic acid affects expression ISO RGD:737613 6480464 Valproic Acid affects the expression of ACVR2B mRNA CTD PMID:25979313 valproic acid decreases expression ISO RGD:737613 6480464 Valproic Acid results in decreased expression of ACVR2B mRNA CTD PMID:23179753 , PMID:28001369 vorinostat decreases expression ISO RGD:737613 6480464 vorinostat results in decreased expression of ACVR2B mRNA CTD PMID:27188386
Biological Process activation of protein kinase activity IDA 2290270 (MGI:MGI:3701721, PMID:16806156) MGI MGI:MGI:3701721 , PMID:16806156 activin receptor signaling pathway ISO UniProtKB:Q13705 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 activin receptor signaling pathway IBA PANTHER:PTN001147373 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 anterior/posterior pattern specification IGI MGI:MGI:1095407 2290270 (MGI:MGI:3525050, PMID:15542835) MGI MGI:MGI:3525050 , PMID:15542835 anterior/posterior pattern specification IMP MGI:MGI:1857709 2290270 (MGI:MGI:3689276 more ... MGI MGI:MGI:3689276 more ... anterior/posterior pattern specification ISO UniProtKB:Q13705 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 anterior/posterior pattern specification IGI MGI:MGI:1857709 , MGI:MGI:2179547 2290270 (MGI:MGI:1344152, PMID:10452853) MGI MGI:MGI:1344152 , PMID:10452853 anterior/posterior pattern specification IGI MGI:MGI:98728 2290270 (MGI:MGI:3695190, PMID:16845371) MGI MGI:MGI:3695190 , PMID:16845371 anterior/posterior pattern specification IGI MGI:MGI:102806 2290270 (MGI:MGI:3689276, PMID:16991118) MGI MGI:MGI:3689276 , PMID:16991118 artery development IMP 2290270 (MGI:MGI:4436974, PMID:19903896) BHF-UCL MGI:MGI:4436974 , PMID:19903896 blood vessel remodeling IMP 2290270 (MGI:MGI:4436974, PMID:19903896) BHF-UCL MGI:MGI:4436974 , PMID:19903896 BMP signaling pathway ISO UniProtKB:Q13705 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 cellular response to growth factor stimulus IBA FB:FBgn0003716 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 determination of left/right symmetry IGI MGI:MGI:102806 2290270 (MGI:MGI:3689276, PMID:16991118) MGI MGI:MGI:3689276 , PMID:16991118 determination of left/right symmetry IMP MGI:MGI:1857709 2290270 (MGI:MGI:894948, PMID:9242489) MGI MGI:MGI:894948 , PMID:9242489 embryonic foregut morphogenesis IMP MGI:MGI:1857709 2290270 (MGI:MGI:1861876, PMID:10921901) MGI MGI:MGI:1861876 , PMID:10921901 gastrulation with mouth forming second IGI MGI:MGI:1857709 , MGI:MGI:2179547 2290270 (MGI:MGI:1344152, PMID:10452853) MGI MGI:MGI:1344152 , PMID:10452853 heart development IMP MGI:MGI:1857709 2290270 (MGI:MGI:894948, PMID:9242489) MGI MGI:MGI:894948 , PMID:9242489 heart development IGI MGI:MGI:108051 2290270 (MGI:MGI:3758991, PMID:17849440) MGI MGI:MGI:3758991 , PMID:17849440 insulin secretion IGI MGI:MGI:108051 2290270 (MGI:MGI:3758991, PMID:17849440) MGI MGI:MGI:3758991 , PMID:17849440 kidney development IGI MGI:MGI:98728 2290270 (MGI:MGI:3695190, PMID:16845371) MGI MGI:MGI:3695190 , PMID:16845371 kidney development IMP MGI:MGI:1857709 2290270 (MGI:MGI:3695190, PMID:16845371) MGI MGI:MGI:3695190 , PMID:16845371 lung development IGI MGI:MGI:108051 2290270 (MGI:MGI:3758991, PMID:17849440) MGI MGI:MGI:3758991 , PMID:17849440 lymphangiogenesis IMP 2290270 (MGI:MGI:4436974, PMID:19903896) BHF-UCL MGI:MGI:4436974 , PMID:19903896 lymphatic endothelial cell differentiation IMP 2290270 (MGI:MGI:4436974, PMID:19903896) BHF-UCL MGI:MGI:4436974 , PMID:19903896 mesoderm development IGI MGI:MGI:1857709 , MGI:MGI:2179547 2290270 (MGI:MGI:1344152, PMID:10452853) MGI MGI:MGI:1344152 , PMID:10452853 negative regulation of cold-induced thermogenesis IMP 2290270 (MGI:MGI:5432851, PMID:22586266) YuBioLab MGI:MGI:5432851 , PMID:22586266 negative regulation of transcription by RNA polymerase II ISO UniProtKB:Q13705 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 odontogenesis of dentin-containing tooth IMP MGI:MGI:1857709 2290270 (MGI:MGI:3611711, PMID:16330774) MGI MGI:MGI:3611711 , PMID:16330774 odontogenesis of dentin-containing tooth IGI MGI:MGI:1857709 , MGI:MGI:2179547 2290270 (MGI:MGI:3611711, PMID:16330774) MGI MGI:MGI:3611711 , PMID:16330774 odontogenesis of dentin-containing tooth IMP MGI:MGI:1857709 , MGI:MGI:2179547 2290270 (MGI:MGI:2155628, PMID:11714685) MGI MGI:MGI:2155628 , PMID:11714685 organ growth IGI MGI:MGI:108051 2290270 (MGI:MGI:3758991, PMID:17849440) MGI MGI:MGI:3758991 , PMID:17849440 pancreas development IGI MGI:MGI:108051 2290270 (MGI:MGI:3758991, PMID:17849440) MGI MGI:MGI:3758991 , PMID:17849440 pattern specification process IGI MGI:MGI:108051 2290270 (MGI:MGI:3758991, PMID:17849440) MGI MGI:MGI:3758991 , PMID:17849440 pattern specification process IBA MGI:MGI:1338938 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 phosphorylation IEA UniProtKB-KW:KW-0418 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 positive regulation of activin receptor signaling pathway ISO UniProtKB:Q13705 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 positive regulation of bone mineralization ISO UniProtKB:Q13705 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 positive regulation of osteoblast differentiation ISO UniProtKB:Q13705 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 post-embryonic development IGI MGI:MGI:108051 2290270 (MGI:MGI:3758991, PMID:17849440) MGI MGI:MGI:3758991 , PMID:17849440 post-embryonic development IMP MGI:MGI:1857709 2290270 (MGI:MGI:3758991, PMID:17849440) MGI MGI:MGI:3758991 , PMID:17849440 protein phosphorylation IEA InterPro:IPR000719 , InterPro:IPR008271 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 protein phosphorylation IBA MGI:MGI:1338944 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 regulation of signal transduction IDA 2290270 (MGI:MGI:3763867, PMID:17936261) MGI MGI:MGI:3763867 , PMID:17936261 regulation of transcription, DNA-templated ISO UniProtKB:Q13705 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 response to glucose IGI MGI:MGI:108051 2290270 (MGI:MGI:3758991, PMID:17849440) MGI MGI:MGI:3758991 , PMID:17849440 retina vasculature development in camera-type eye IMP 2290270 (MGI:MGI:4436974, PMID:19903896) BHF-UCL MGI:MGI:4436974 , PMID:19903896 roof of mouth development IGI MGI:MGI:98728 2290270 (MGI:MGI:3695190, PMID:16845371) MGI MGI:MGI:3695190 , PMID:16845371 roof of mouth development IMP MGI:MGI:1857709 2290270 (MGI:MGI:3695190, PMID:16845371) MGI MGI:MGI:3695190 , PMID:16845371 signal transduction ISO UniProtKB:Q13705 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 skeletal system development IMP MGI:MGI:1857709 2290270 (MGI:MGI:3695190, PMID:16845371) MGI MGI:MGI:3695190 , PMID:16845371 skeletal system development IGI MGI:MGI:98728 2290270 (MGI:MGI:3695190, PMID:16845371) MGI MGI:MGI:3695190 , PMID:16845371 skeletal system morphogenesis IMP MGI:MGI:1857709 2290270 (MGI:MGI:3689276, PMID:16991118) MGI MGI:MGI:3689276 , PMID:16991118 skeletal system morphogenesis IGI MGI:MGI:98728 2290270 (MGI:MGI:3695190, PMID:16845371) MGI MGI:MGI:3695190 , PMID:16845371 transforming growth factor beta receptor signaling pathway IBA FB:FBgn0003716 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 transmembrane receptor protein serine/threonine kinase signaling pathway IEA InterPro:IPR000333 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 venous blood vessel development IMP 2290270 (MGI:MGI:4436974, PMID:19903896) BHF-UCL MGI:MGI:4436974 , PMID:19903896 Cellular Component activin receptor complex IBA PANTHER:PTN001147373 , UniProtKB:A0A0B4KG59 2290270 (PMID:21873635) GO_Central PMID:21873635 cytoplasm ISO UniProtKB:Q13705 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 integral component of membrane IEA UniProtKB-KW:KW-0812 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 integral component of plasma membrane IBA MGI:MGI:87911 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 membrane IEA UniProtKB-KW:KW-0472 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 membrane IEA InterPro:IPR000333 , InterPro:IPR000472 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 plasma membrane IEA UniProtKB-KW:KW-1003 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 plasma membrane IBA FB:FBgn0011300 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 protein-containing complex ISO UniProtKB:Q13705 2290270 (MGI:MGI:5511086, PMID:24019467) MGI MGI:MGI:5511086 , PMID:24019467 receptor complex ISO UniProtKB:Q13705 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 receptor complex IBA PANTHER:PTN000583675 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 receptor complex IBA FB:FBgn0011300 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 Molecular Function activin binding IDA 2290270 (MGI:MGI:3050899, PMID:15304227) MGI MGI:MGI:3050899 , PMID:15304227 activin binding IBA MGI:MGI:102806 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 activin binding IBA MGI:MGI:102806 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 activin binding IBA MGI:MGI:87912 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 activin binding IPI UniProtKB:P08476 2290270 (MGI:MGI:50828 more ... MGI MGI:MGI:50828 more ... activin binding ISO RGD:2028 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 activin-activated receptor activity IBA PANTHER:PTN001147373 , UniProtKB:A0A0B4KG59 2290270 (PMID:21873635) GO_Central PMID:21873635 ATP binding IEA InterPro:IPR000333 , InterPro:IPR000719 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 ATP binding IEA UniProtKB-KW:KW-0067 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 growth factor binding IPI UniProtKB:O08689 2290270 (MGI:MGI:2137985, PMID:11459935) MGI MGI:MGI:2137985 , PMID:11459935 growth factor binding IBA MGI:MGI:102806 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 growth factor binding ISO UniProtKB:Q13705 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 growth factor binding IMP UniProtKB:O95390 2290270 (MGI:MGI:2389524, PMID:12414726) MGI MGI:MGI:2389524 , PMID:12414726 inhibin binding ISO RGD:2028 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 kinase activity IEA UniProtKB-KW:KW-0418 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 metal ion binding IEA UniProtKB-KW:KW-0479 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 nucleotide binding IEA UniProtKB-KW:KW-0547 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 protein binding IPI UniProtKB:Q6Y642 2290270 (MGI:MGI:2180417, PMID:11882656) MGI MGI:MGI:2180417 , PMID:11882656 protein binding IPI UniProtKB:P36896 2290270 (MGI:MGI:5918418, PMID:14966532) IntAct MGI:MGI:5918418 , PMID:14966532 protein binding IPI UniProtKB:Q922H7 2290270 (MGI:MGI:3505646, PMID:15239668) MGI MGI:MGI:3505646 , PMID:15239668 protein binding IPI UniProtKB:Q9Z1W4 2290270 (MGI:MGI:3695190, PMID:16845371) MGI MGI:MGI:3695190 , PMID:16845371 protein kinase activity IEA InterPro:IPR000719 , InterPro:IPR008271 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 protein serine/threonine kinase activity IDA 2290270 (MGI:MGI:51043, PMID:1326537) MGI MGI:MGI:51043 , PMID:1326537 protein serine/threonine kinase activity IBA MGI:MGI:102806 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 protein serine/threonine kinase activity ISO UniProtKB:Q13705 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 protein serine/threonine/tyrosine kinase activity IDA 2290270 (MGI:MGI:51043, PMID:1326537) MGI MGI:MGI:51043 , PMID:1326537 SMAD binding IBA MGI:MGI:98728 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 transferase activity IEA UniProtKB-KW:KW-0808 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 transforming growth factor beta binding NOT IDA 2290270 (MGI:MGI:51043, PMID:1326537) MGI MGI:MGI:51043 , PMID:1326537 transforming growth factor beta receptor activity, type II IBA PANTHER:PTN001147373 , RGD:69651 2290270 (PMID:21873635) GO_Central PMID:21873635 transforming growth factor beta-activated receptor activity IBA MGI:MGI:98728 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 transmembrane receptor protein serine/threonine kinase activity IEA InterPro:IPR000333 , InterPro:IPR000472 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 type I transforming growth factor beta receptor binding IBA PANTHER:PTN001147373 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635
Gene-Chemical Interaction Annotations
