RGD Reference Report - Advantages of promoting interleukin-10 by silence of histone deacetylase 11 in inducing tolerance in orthotopic liver transplantation in rats. - Rat Genome Database

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Advantages of promoting interleukin-10 by silence of histone deacetylase 11 in inducing tolerance in orthotopic liver transplantation in rats.

Authors: Lai, X  Li, JZ  Lian, ZR  Niu, BL  Chen, Y  Liao, WY  Liu, ZJ  Gong, JP 
Citation: Lai X, etal., Transplant Proc. 2011 Sep;43(7):2728-32. doi: 10.1016/j.transproceed.2011.05.044.
RGD ID: 11049478
Pubmed: PMID:21911153   (View Abstract at PubMed)
DOI: DOI:10.1016/j.transproceed.2011.05.044   (Journal Full-text)

AIMS: The aims of this study were to study the role of histone deacetylase 11 (HDAC11) in tolerance induction in orthotopic liver transplantation (OLT) in rats and to assess the advantages of gene therapy over the immunosuppressant FK506. METHODS: Recipients were assigned to an acute rejection group (AcR; group I), an FK506 intervention group (group II), and a tolerance group (group III). Acute rejection (AcR) was graded by the Banff scheme and we examined postoperative survival. The messenger RNA (mRNA) and protein expressions of histone deacetylase 11 (HDAC11) and interleukin (IL) 10 in liver tissue were detected using real-time polymerase chain reaction (PCR) and Western blots, respectively. Plasma levels of tumor necrosis factor (TNF)-alpha, IL-2, and IL-10 were measured using enzyme-linked immunosorbent Assays. RESULTS: Group I displayed severe, Group II had less, and Group III had no evidence of AR. The survivals among Group III were longer than those in Group I and Group II. IL-10 expression was promoted by HDAC11-shRNA at 7 days after OLT. Serum IL-2 and TNF-alpha levels were significantly lower among Group III compared with Groups I and II, whereas IL-10 showed the opposite result. CONCLUSIONS: Silence of HDAC11 promotes IL-10 expression and leads to tolerance following OLT in rats. Thus HDAC11 is a promising target for gene therapy to induce tolerance with advantages over immunosuppressive drugs.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IL10HumanPrimary Graft Dysfunction treatmentISOIl10 (Rattus norvegicus) RGD 
Il10RatPrimary Graft Dysfunction treatmentIDA  RGD 
Il10MousePrimary Graft Dysfunction treatmentISOIl10 (Rattus norvegicus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il10  (interleukin 10)

Genes (Mus musculus)
Il10  (interleukin 10)

Genes (Homo sapiens)
IL10  (interleukin 10)


Additional Information