Gene: Entpd1 (ectonucleoside triphosphate diphosphohydrolase 1) Mus musculus
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Symbol:
Entpd1
Name:
ectonucleoside triphosphate diphosphohydrolase 1
Description:
Exhibits nucleoside-diphosphatase activity and nucleoside-triphosphatase activity. Involved in G protein-coupled receptor signaling pathway; platelet activation; and purine ribonucleoside diphosphate catabolic process. Localizes to the basement membrane. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 64. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and respiratory system. Orthologous to human ENTPD1 (ectonucleoside triphosphate diphosphohydrolase 1); PARTICIPATES IN purine metabolic pathway; pyrimidine metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine; aldehydo-D-glucose.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
2610206B08Rik; AA408691; Cd39; CD39 antigen; E130009M23Rik; ecto-apyrase; ecto-ATP diphosphohydrolase 1; ecto-ATPase 1; ecto-ATPDase 1; ectoapyrase; lymphoid cell activation antigen; NTPDase 1; NTPDase-1
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
ENTPD1 (ectonucleoside triphosphate diphosphohydrolase 1) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Entpd1 (ectonucleoside triphosphate diphosphohydrolase 1) HGNC
EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Entpd1 (ectonucleoside triphosphate diphosphohydrolase 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
ENTPD1 (ectonucleoside triphosphate diphosphohydrolase 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
ENTPD1 (ectonucleoside triphosphate diphosphohydrolase 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
ENTPD1 (ectonucleoside triphosphate diphosphohydrolase 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Entpd1 (ectonucleoside triphosphate diphosphohydrolase 1)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Homo sapiens (human):
ENTPD1 (ectonucleoside triphosphate diphosphohydrolase 1)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Danio rerio (zebrafish):
entpd1 (ectonucleoside triphosphate diphosphohydrolase 1)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38 Ensembl 19 40,612,366 - 40,741,602 (+) Ensembl GRCm38 19 40,612,366 - 40,741,602 (+) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 19 40,734,284 - 40,816,092 (+) NCBI GRCm37 mm9 NCBIm37 MGSCv36 19 40,751,297 - 40,794,913 (+) NCBI mm8 Celera 19 41,460,982 - 41,543,158 (+) NCBI Celera Cytogenetic Map 19 C3 NCBI cM Map 19 34.25 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
Developmental Disabilities ISO RGD:733329 8554872 ClinVar Annotator: match by term: Global developmental delay ClinVar PMID:25741868 , PMID:28492532 hereditary spastic paraplegia 64 ISO RGD:733329 8554872 ClinVar Annotator: match by term: Spastic paraplegia 64, autosomal recessive ClinVar PMID:28492532 hereditary spastic paraplegia 64 ISO RGD:733329 8554872 ClinVar Annotator: match by term: Spastic paraplegia 64, autosomal recessive ClinVar PMID:30652007 hereditary spastic paraplegia 64 ISO RGD:733329 8554872 ClinVar Annotator: match by term: Spastic paraplegia 64, autosomal recessive ClinVar PMID:25741868 hereditary spastic paraplegia 64 ISO RGD:733329 8554872 ClinVar Annotator: match by term: Spastic paraplegia 64, autosomal recessive ClinVar PMID:25741868 , PMID:28492532 hereditary spastic paraplegia 64 ISO RGD:733329 8554872 ClinVar Annotator: match by OMIM:615683 ClinVar PMID:24482476 Polymicrogyria ISO RGD:733329 8554872 ClinVar Annotator: match by term: Polymicrogyria ClinVar PMID:25741868 , PMID:28492532
Imported Annotations - CTD
intellectual disability ISO RGD:733329 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:21937992 Imported Annotations - OMIM
hereditary spastic paraplegia 64 ISO RGD:733329 7240710 OMIM
17beta-estradiol multiple interactions ISO RGD:733329 6480464 [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of ENTPD1 mRNA CTD PMID:19619570 17beta-estradiol decreases expression ISO RGD:733329 6480464 Estradiol results in decreased expression of ENTPD1 mRNA CTD PMID:21185374 17beta-estradiol increases expression ISO RGD:733329 6480464 Estradiol results in increased expression of ENTPD1 mRNA CTD PMID:19619570 2,2',4,4'-Tetrabromodiphenyl ether increases expression ISO RGD:69265 6480464 2 more ... CTD PMID:20566336 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:733329 6480464 Tetrachlorodibenzodioxin results in decreased expression of ENTPD1 mRNA CTD PMID:17101203 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of ENTPD1 mRNA CTD PMID:26377647 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:733329 6480464 Tetrachlorodibenzodioxin results in increased expression of ENTPD1 mRNA CTD PMID:19619570 , PMID:27783946 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:733329 6480464 [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of ENTPD1 mRNA, [Tetrachlorodibenzodioxin co-treated with TGFB1 protein] results in increased expression of ENTPD1 mRNA CTD PMID:19619570 , PMID:27783946 2,4-dinitrotoluene affects expression ISO RGD:69265 6480464 2, 4-dinitrotoluene affects the expression of ENTPD1 mRNA CTD PMID:21346803 3,4-methylenedioxymethamphetamine increases expression EXP 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in increased expression of ENTPD1 mRNA CTD PMID:20188158 5-azacytidine increases expression ISO RGD:733329 6480464 Azacitidine results in increased expression of ENTPD1 mRNA CTD PMID:20823114 5-fluorouracil decreases expression ISO RGD:733329 6480464 Fluorouracil results in decreased expression of ENTPD1 mRNA CTD PMID:19219653 aflatoxin B1 increases methylation ISO RGD:733329 6480464 Aflatoxin B1 results in increased methylation of ENTPD1 intron CTD PMID:30157460 aldehydo-D-glucose increases expression EXP 6480464 Glucose results in increased expression of ENTPD1 mRNA CTD PMID:31525975 ammonium chloride affects expression ISO RGD:69265 6480464 Ammonium Chloride affects the expression of ENTPD1 mRNA CTD PMID:16483693 amphetamine increases expression ISO RGD:69265 6480464 Amphetamine results in increased expression of ENTPD1 mRNA CTD PMID:30779732 antirheumatic drug decreases expression ISO RGD:733329 6480464 Antirheumatic Agents results in decreased expression of ENTPD1 mRNA CTD PMID:24449571 arsane affects methylation ISO RGD:733329 6480464 Arsenic affects the methylation of ENTPD1 gene CTD PMID:25304211 arsenic atom affects methylation ISO RGD:733329 6480464 Arsenic affects the methylation of ENTPD1 gene CTD PMID:25304211 bisphenol A decreases expression ISO RGD:69265 6480464 bisphenol A results in decreased expression of ENTPD1 mRNA CTD PMID:25181051 , PMID:30816183 bisphenol A increases expression ISO RGD:733329 6480464 bisphenol A results in increased expression of ENTPD1 mRNA CTD PMID:29275510 carbon nanotube increases expression EXP 6480464 Nanotubes, Carbon analog results in increased expression of ENTPD1 mRNA, Nanotubes, Carbon results in increased expression of ENTPD1 mRNA CTD PMID:25554681 cerivastatin multiple interactions ISO RGD:733329 6480464 cerivastatin inhibits the reaction [F2 protein results in decreased expression of ENTPD1 protein] CTD PMID:12067895 cisplatin increases expression ISO RGD:733329 6480464 Cisplatin results in increased expression of ENTPD1 mRNA CTD PMID:27392435 cisplatin multiple interactions ISO RGD:733329 6480464 [Cisplatin co-treated with jinfukang] results in increased expression of ENTPD1 mRNA CTD PMID:27392435 cobalt dichloride increases expression ISO RGD:733329 6480464 cobaltous chloride results in increased expression of ENTPD1 protein CTD PMID:27899277 cyhalothrin increases expression ISO RGD:69265 6480464 cyhalothrin results in increased expression of ENTPD1 mRNA CTD PMID:31421116 cytarabine increases expression ISO RGD:733329 6480464 Cytarabine results in increased expression of ENTPD1 mRNA CTD PMID:19194470 D-glucose increases expression EXP 6480464 Glucose results in increased expression of ENTPD1 mRNA CTD PMID:31525975 Deguelin multiple interactions ISO RGD:733329 6480464 deguelin inhibits the reaction [Oxygen deficiency results in increased expression of ENTPD1 protein] CTD PMID:27899277 dibenzofuran increases expression ISO RGD:69265 6480464 dibenzofuran analog results in increased expression of ENTPD1 mRNA CTD PMID:20566336 dibutyl phthalate increases expression EXP 6480464 Dibutyl Phthalate results in increased expression of ENTPD1 mRNA CTD PMID:21266533 dibutyl phthalate decreases expression EXP 6480464 Dibutyl Phthalate results in decreased expression of ENTPD1 mRNA CTD PMID:21266533 dioxygen increases expression EXP 6480464 Oxygen deficiency results in increased expression of ENTPD1 mRNA, Oxygen deficiency results in increased expression of ENTPD1 protein CTD PMID:23437309 dioxygen multiple interactions EXP 6480464 [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of ENTPD1 mRNA CTD PMID:30529165 dioxygen increases expression ISO RGD:733329 6480464 Oxygen deficiency results in increased expression of ENTPD1 mRNA, Oxygen deficiency results in increased expression of ENTPD1 protein CTD PMID:27899277 dioxygen multiple interactions ISO RGD:733329 6480464 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin inhibits the reaction [Oxygen deficiency results in increased expression of ENTPD1 protein] more ... CTD PMID:27899277 diuron decreases expression ISO RGD:69265 6480464 Diuron results in decreased expression of ENTPD1 mRNA CTD PMID:25152437 diuron increases expression ISO RGD:69265 6480464 Diuron results in increased expression of ENTPD1 mRNA CTD PMID:21551480 dorsomorphin multiple interactions ISO RGD:733329 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ENTPD1 mRNA CTD PMID:27188386 endosulfan decreases expression ISO RGD:69265 6480464 Endosulfan results in decreased expression of ENTPD1 mRNA CTD PMID:29391264 entinostat multiple interactions ISO RGD:733329 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ENTPD1 mRNA CTD PMID:27188386 entinostat increases expression ISO RGD:733329 6480464 entinostat results in increased expression of ENTPD1 mRNA CTD PMID:26272509 , PMID:27188386 ethanol multiple interactions EXP 6480464 [Carbon Tetrachloride co-treated with Ethanol] results in increased expression of ENTPD1 mRNA CTD PMID:30517762 ethanol increases expression EXP 6480464 Ethanol results in increased expression of ENTPD1 mRNA CTD PMID:30319688 ethyl methanesulfonate decreases expression ISO RGD:733329 6480464 Ethyl Methanesulfonate results in decreased expression of ENTPD1 mRNA CTD PMID:23649840 ethylbenzene multiple interactions ISO RGD:733329 6480464 [Toluene co-treated with ethylbenzene co-treated with Xylenes] results in decreased methylation of ENTPD1 gene, [Toluene co-treated with ethylbenzene co-treated with Xylenes] results in increased expression of ENTPD1 mRNA CTD PMID:26018793 flavonoids increases expression ISO RGD:69265 6480464 Flavonoids results in increased expression of ENTPD1 mRNA CTD PMID:18035473 formaldehyde decreases expression ISO RGD:733329 6480464 Formaldehyde results in decreased expression of ENTPD1 mRNA CTD PMID:23649840 glucose increases expression EXP 6480464 Glucose results in increased expression of ENTPD1 mRNA CTD PMID:31525975 isoprenaline increases expression EXP 6480464 Isoproterenol results in increased expression of ENTPD1 mRNA CTD PMID:20003209 lead(0) increases expression ISO RGD:733329 6480464 Lead results in increased expression of ENTPD1 mRNA CTD PMID:19921347 lead(2+) increases expression ISO RGD:733329 6480464 Lead results in increased expression of ENTPD1 mRNA CTD PMID:19921347 lipopolysaccharide multiple interactions EXP 6480464 ENTPD1 protein inhibits the reaction [Silicon Dioxide analog promotes the reaction [Lipopolysaccharides results in increased expression of IL1B protein]] CTD PMID:24685903 methyl methanesulfonate decreases expression ISO RGD:733329 6480464 Methyl Methanesulfonate results in decreased expression of ENTPD1 mRNA CTD PMID:23649840 nickel atom increases expression ISO RGD:733329 6480464 Nickel results in increased expression of ENTPD1 mRNA CTD PMID:24768652 , PMID:25583101 nickel sulfate increases expression ISO RGD:733329 6480464 nickel sulfate results in increased expression of ENTPD1 mRNA CTD PMID:16780908 paracetamol affects expression EXP 6480464 Acetaminophen affects the expression of ENTPD1 mRNA CTD PMID:17562736 pentanal increases expression ISO RGD:733329 6480464 pentanal results in increased expression of ENTPD1 mRNA CTD PMID:26079696 pirinixic acid decreases expression EXP 6480464 pirinixic acid results in decreased expression of ENTPD1 mRNA CTD PMID:20813756 pirinixic acid increases expression EXP 6480464 pirinixic acid results in increased expression of ENTPD1 mRNA CTD PMID:17690133 SB 431542 multiple interactions ISO RGD:733329 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ENTPD1 mRNA CTD PMID:27188386 silicon dioxide multiple interactions ISO RGD:733329 6480464 ENTPD1 protein inhibits the reaction [Silicon Dioxide analog results in increased expression of IL6 protein] CTD PMID:24793913 silicon dioxide multiple interactions EXP 6480464 ENTPD1 protein inhibits the reaction [Silicon Dioxide analog promotes the reaction [Lipopolysaccharides results in increased expression of IL1B protein]] CTD PMID:24685903 simvastatin multiple interactions ISO RGD:733329 6480464 Simvastatin inhibits the reaction [F2 protein results in decreased expression of ENTPD1 protein] CTD PMID:12067895 sodium arsenite decreases methylation ISO RGD:733329 6480464 sodium arsenite results in decreased methylation of ENTPD1 gene CTD PMID:24570342 Soman increases expression ISO RGD:69265 6480464 Soman results in increased expression of ENTPD1 mRNA CTD PMID:19281266 testosterone enanthate affects expression ISO RGD:733329 6480464 testosterone enanthate affects the expression of ENTPD1 mRNA CTD PMID:17440010 tetrachloromethane multiple interactions EXP 6480464 [Carbon Tetrachloride co-treated with Ethanol] results in increased expression of ENTPD1 mRNA CTD PMID:30517762 thioacetamide increases expression EXP 6480464 Thioacetamide results in increased expression of ENTPD1 mRNA, Thioacetamide results in increased expression of ENTPD1 protein CTD PMID:27899277 thioacetamide decreases response to substance EXP 6480464 ENTPD1 protein results in decreased susceptibility to Thioacetamide CTD PMID:27899277 toluene multiple interactions ISO RGD:733329 6480464 [Toluene co-treated with ethylbenzene co-treated with Xylenes] results in decreased methylation of ENTPD1 gene, [Toluene co-treated with ethylbenzene co-treated with Xylenes] results in increased expression of ENTPD1 mRNA CTD PMID:26018793 tungsten decreases expression EXP 6480464 Tungsten results in decreased expression of ENTPD1 mRNA CTD PMID:30912803 valproic acid decreases expression ISO RGD:733329 6480464 Valproic Acid results in decreased expression of ENTPD1 mRNA CTD PMID:23179753 valproic acid increases expression ISO RGD:733329 6480464 Valproic Acid results in increased expression of ENTPD1 mRNA CTD PMID:28001369 vitamin E increases expression ISO RGD:733329 6480464 Vitamin E results in increased expression of ENTPD1 mRNA CTD PMID:19244175 vorinostat increases expression ISO RGD:69265 6480464 vorinostat results in increased expression of ENTPD1 mRNA CTD PMID:20060208
Biological Process G protein-coupled receptor signaling pathway IDA 2290270 (MGI:MGI:2178511, PMID:11929769) MGI MGI:MGI:2178511 , PMID:11929769 negative regulation of ATP biosynthetic process ISO RGD:69265 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 negative regulation of dopamine secretion ISO RGD:69265 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 platelet activation IDA 2290270 (MGI:MGI:2178511, PMID:11929769) MGI MGI:MGI:2178511 , PMID:11929769 protein homooligomerization ISO RGD:69265 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 purine ribonucleoside diphosphate catabolic process IDA 2290270 (MGI:MGI:2178511, PMID:11929769) MGI MGI:MGI:2178511 , PMID:11929769 Cellular Component basement membrane IDA 2290270 (MGI:MGI:2178511, PMID:11929769) MGI MGI:MGI:2178511 , PMID:11929769 basolateral plasma membrane ISO RGD:69265 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 cell surface ISO RGD:69265 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 extracellular space ISO RGD:69265 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 integral component of membrane IEA UniProtKB-KW:KW-0812 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 membrane IEA UniProtKB-KW:KW-0472 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 neuron projection ISO RGD:69265 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 neuronal cell body ISO RGD:69265 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 postsynaptic density ISO RGD:69265 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 synaptic membrane ISO RGD:69265 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 synaptic vesicle ISO RGD:69265 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 Molecular Function 8-oxo-dGTP phosphohydrolase activity IEA EC:3.6.1.5 2290270 UniProtKB GO_REF:0000003, MGI:MGI:2152096 adenosine-diphosphatase activity ISO RGD:69265 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 ATP binding IEA UniProtKB-KW:KW-0067 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 ATPase activity ISO RGD:69265 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 hydrolase activity IEA InterPro:IPR000407 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 hydrolase activity IEA UniProtKB-KW:KW-0378 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 identical protein binding ISO RGD:69265 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 nucleoside-diphosphatase activity IDA 2290270 (MGI:MGI:2178511, PMID:11929769) MGI MGI:MGI:2178511 , PMID:11929769 nucleoside-triphosphatase activity IDA 2290270 (MGI:MGI:2178511, PMID:11929769) MGI MGI:MGI:2178511 , PMID:11929769 nucleotide binding IEA UniProtKB-KW:KW-0547 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194
Gene-Chemical Interaction Annotations
