RGD Reference Report - Platelet factor 4 protects kidney allograft in a rat kidney transplantation model. - Rat Genome Database

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Platelet factor 4 protects kidney allograft in a rat kidney transplantation model.

Authors: Zhang, Lei  Zhu, Yichen  Zhang, Dong  Zhang, Jian  Tian, Ye 
Citation: Zhang L, etal., Inflammation. 2015 Apr;38(2):520-6. doi: 10.1007/s10753-014-9958-2.
RGD ID: 329901907
Pubmed: PMID:24986443   (View Abstract at PubMed)
DOI: DOI:10.1007/s10753-014-9958-2   (Journal Full-text)

Platelets are the cellular mediator of thrombosis, but it is becoming increasingly evident that platelets actively participate in inflammation and immune responses. A recent paper indicated that platelet factor 4 (PF4) alleviated cardiac allograft rejection in mice. But the role of PF4 on kidney transplantation has never been investigated. In our current experiment, PF4 administration alleviates immune responses to kidney transplantation. PF4 significantly alleviates vascular and glomerular changes, as well as interstitial inflammation, fibrosis, and tubular atrophy at day 56 after transplantation. PF4 decreases interleukin (IL)-17 production in vivo and also limits Th17 differentiation in vitro. Furthermore, the alleviated chronic vasculopathy and tubulointerstitial inflammation induced by PF4 were abolished with additional IL-17 administration. Meanwhile, decreased serum creatinine and urea induced by PF4 were also reversed by recombinant mouse IL-17 (rmIL-17). In conclusion, PF4 plays a protective role in chronic kidney allograft and this was associated with inhibition of IL-17 production.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Primary Graft Dysfunction amelioratesISOPf4 (Rattus norvegicus)329901907; 329901907 RGD 
Primary Graft Dysfunction amelioratesIDA 329901907 RGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
negative regulation of inflammatory response  IDA 329901907 RGD 
negative regulation of T-helper 17 cell differentiation  IDA 329901907 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Pf4  (platelet factor 4)

Genes (Mus musculus)
Pf4  (platelet factor 4)

Genes (Homo sapiens)
PF4  (platelet factor 4)


Additional Information