Cxcr1 (C-X-C motif chemokine receptor 1) - Rat Genome Database

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Gene: Cxcr1 (C-X-C motif chemokine receptor 1) Mus musculus
Analyze
Symbol: Cxcr1
Name: C-X-C motif chemokine receptor 1
RGD ID: 733954
MGI Page MGI
Description: Predicted to enable chemokine binding activity and chemokine receptor activity. Predicted to be involved in several processes, including calcium-mediated signaling; neutrophil chemotaxis; and receptor internalization. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. Is expressed in bone marrow and lung. Human ortholog(s) of this gene implicated in human immunodeficiency virus infectious disease; pyelonephritis; and urinary tract infection. Orthologous to human CXCR1 (C-X-C motif chemokine receptor 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C-X-C chemokine receptor type 1; chemokine (C-X-C motif) receptor 1; CXC chemokine receptor 1; CXC chemokine receptor 1-like; CXC-R1; CXCR-1; high affinity interleukin-8 receptor A; I; IL-8R A; Il8ra; interleukin 8 receptor, alpha
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39174,228,862 - 74,233,867 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl174,230,944 - 74,233,790 (-)EnsemblGRCm39 Ensembl
GRCm38174,191,785 - 74,194,708 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl174,191,785 - 74,194,631 (-)EnsemblGRCm38mm10GRCm38
MGSCv37174,238,359 - 74,241,205 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36174,124,992 - 74,126,442 (-)NCBIMGSCv36mm8
Celera174,753,154 - 74,755,998 (-)NCBICelera
Cytogenetic Map1C3NCBI
cM Map138.44NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Genetic variations of interleukin-8, CXCR1 and CXCR2 genes and risk of acute pyelonephritis in children. Javor J, etal., Int J Immunogenet. 2012 Aug;39(4):338-45. doi: 10.1111/j.1744-313X.2012.01096.x. Epub 2012 Feb 10.
2. A genetic basis of susceptibility to acute pyelonephritis. Lundstedt AC, etal., PLoS One. 2007 Sep 5;2(9):e825.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. MGD IEA MGD IEA
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. Role of CXCR1 (CKR-1) in Inflammation of Experimental Mesangioproliferative Glomerulonephritis. Ozaltin F, etal., Ren Fail. 2013 Jan 22.
7. Neutrophil and monocyte activation in chronic kidney disease patients under hemodialysis and its relationship with resistance to recombinant human erythropoietin and to the hemodialysis procedure. Pereira R, etal., Hemodial Int. 2010 Jul;14(3):295-301. doi: 10.1111/j.1542-4758.2010.00450.x.
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. Mouse MP Annotation Import Pipeline RGD automated import pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Association of polymorphisms of interleukin-8, CXCR1, CXCR2, and selectin with allograft outcomes in kidney transplantation. Ro H, etal., Transplantation. 2011 Jan 15;91(1):57-64.
13. Association of Toll-like receptor 4 gene polymorphism and expression with urinary tract infection types in adults. Yin X, etal., PLoS One. 2010 Dec 3;5(12):e14223. doi: 10.1371/journal.pone.0014223.
Additional References at PubMed
PMID:14610273   PMID:15967374   PMID:16084593   PMID:17062627   PMID:17197447   PMID:17704296   PMID:18059279   PMID:18668539   PMID:20082763   PMID:20335311   PMID:21254176   PMID:21267068  
PMID:21677750   PMID:21693308   PMID:21873635   PMID:22277947   PMID:22869904   PMID:22996693   PMID:23550035   PMID:24651866   PMID:25129059   PMID:25891236   PMID:26230114   PMID:26791948  
PMID:26950764   PMID:27551720   PMID:28341702   PMID:28504723   PMID:29445180   PMID:30218547   PMID:30799265   PMID:30973865   PMID:31058213   PMID:31231364   PMID:31573846   PMID:32289253  
PMID:34120407   PMID:36325326   PMID:37207443   PMID:37709757   PMID:38355793  


Genomics

Comparative Map Data
Cxcr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39174,228,862 - 74,233,867 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl174,230,944 - 74,233,790 (-)EnsemblGRCm39 Ensembl
GRCm38174,191,785 - 74,194,708 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl174,191,785 - 74,194,631 (-)EnsemblGRCm38mm10GRCm38
MGSCv37174,238,359 - 74,241,205 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36174,124,992 - 74,126,442 (-)NCBIMGSCv36mm8
Celera174,753,154 - 74,755,998 (-)NCBICelera
Cytogenetic Map1C3NCBI
cM Map138.44NCBI
CXCR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382218,162,841 - 218,166,962 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2218,162,841 - 218,166,962 (-)EnsemblGRCh38hg38GRCh38
GRCh372219,027,564 - 219,031,685 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362218,735,813 - 218,739,961 (-)NCBINCBI36Build 36hg18NCBI36
Build 342218,853,075 - 218,857,222NCBI
Celera2212,794,153 - 212,798,301 (-)NCBICelera
Cytogenetic Map2q35NCBI
HuRef2210,880,311 - 210,884,459 (-)NCBIHuRef
CHM1_12219,034,054 - 219,038,202 (-)NCBICHM1_1
T2T-CHM13v2.02218,648,531 - 218,652,652 (-)NCBIT2T-CHM13v2.0
Cxcr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8983,216,040 - 83,220,225 (-)NCBIGRCr8
mRatBN7.2975,766,894 - 75,771,079 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl975,766,770 - 75,771,084 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx984,221,913 - 84,222,962 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0989,350,842 - 89,351,891 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0987,737,061 - 87,738,110 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0981,466,430 - 81,469,299 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl981,466,332 - 81,469,274 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0981,232,019 - 81,235,417 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4973,510,488 - 73,511,537 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1973,657,469 - 73,658,519 (-)NCBI
Celera973,345,732 - 73,346,781 (-)NCBICelera
Cytogenetic Map9q33NCBI
Cxcr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545315,194,205 - 15,195,272 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545315,181,027 - 15,196,224 (+)NCBIChiLan1.0ChiLan1.0
CXCR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213120,802,384 - 120,862,522 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B120,817,351 - 120,877,489 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B105,429,576 - 105,433,243 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B224,027,533 - 224,031,675 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B224,028,838 - 224,029,890 (-)Ensemblpanpan1.1panPan2
Cxcr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303174,371,818 - 174,373,425 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936569715,129 - 716,181 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936569715,129 - 716,187 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CXCR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110104,052,709 - 104,056,388 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10104,053,544 - 104,054,620 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604095,344,477 - 95,348,616 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cxcr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248236,859,356 - 6,860,426 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248236,857,649 - 6,861,219 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cxcr1
323 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:82
Count of miRNA genes:74
Interacting mature miRNAs:76
Transcripts:ENSMUST00000053389
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
1301714Vertcling_mvertical clinging (mouse)Not determined14293803176938167Mouse
4142394Mssq1_mmandible size and shape QTL 1 (mouse)Not determined73615692107615830Mouse
18182931Metl1_mmetabolite locus 1, pyridoxate (mouse)14127539975275399Mouse
4141305Tgq9_mtriglyceride QTL 9 (mouse)Not determined5142160585421605Mouse
4141625Emo4_memotionality 4 (mouse)Not determined6807134586235027Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163854690189303617Mouse
1301211Bbaa11_mB.burgdorferi-associated arthritis 11 (mouse)Not determined14888900682889210Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145783900189303617Mouse
14697705Stsl3b_mSalmonella typhimurium susceptibility locus 3b (mouse)17413915981777715Mouse
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
1357721Sle17_msystematic lupus erythematosus susceptibility 17 (mouse)Not determined139132808126445310Mouse
1301954Lrnx11_mlearning-contextual 11 (mouse)Not determined13913280874516365Mouse
1302146Cocrb1_mcocaine related behavior 1 (mouse)Not determined170133533104139557Mouse
1357505Vtbt1_mvertebral trabecular bone trait 1 (mouse)Not determined15626621490266360Mouse
4141032Wbcc1_mwhite blood cell count 1 (mouse)Not determined4225966776259667Mouse
14746998Mancz1_mmandible centroid size 1 (mouse)15794135191941351Mouse
1301444Alcw5_malcohol withdrawal 5 (mouse)Not determined15854919192549443Mouse
1300746Skl1_mskeletal size (tail length) 1 (mouse)Not determined15799197791992080Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134760138150193871Mouse
14747009Manh49_mmandible shape 49 (mouse)15794135191941351Mouse
1301616Yaa2_mY-linked autoimmune acceleration 2 (mouse)Not determined14685469080854839Mouse
1300976Bmd19_mbone mineral density 19 (mouse)Not determined173266214108838414Mouse
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134760138150193871Mouse
10043965Obq24_mobesity QTL 24 (mouse)Not determined15089021684890216Mouse
1301430Cdcs2_mcytokine deficiency colitis susceptibility 2 (mouse)Not determined14889234582892485Mouse
1301748Abbp1_mA/J and C57BL/6 blood pressure 1 (mouse)Not determined162946755120529678Mouse
1558717Ses1a_msalmonella enteritidis susceptibility 1a (mouse)Not determined15672692290727077Mouse
1301304Hrq3_mheart rate quantitative locus 3 (mouse)Not determined173615692107615830Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52457737182250592Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134760138150193871Mouse
1558905Gct7_mgranulosa cell tumorigenesis 7 (mouse)Not determined14734989481350013Mouse
4141393Mol2_mmodifier of LPS-response 2 (mouse)Not determined7162467978183144Mouse
1300989Lrdg1_mlight induced retinal degeneration 1 (mouse)Not determined173755175147125370Mouse
1301667Lxw5_mlupus BXSB x NZW 5 (mouse)Not determined15854919192549443Mouse
1558822Vas1_mautoimmune vasitis resistance 1 (mouse)Not determined14888900682889210Mouse
27095918Ulnl1_mulna length 1, 5 week (mouse)167339159129727737Mouse
1302119Cia15_mcollagen induced arthritis 15 (mouse)Not determined16588900688496101Mouse
1301670Ssta1_msusceptibility to Salmonella typhimurium antigens 1 (mouse)Not determined14594675579946882Mouse
1357741Nidd5k_mNidd5 on KK-A<y> (mouse)Not determined15597494889975057Mouse
1301162Skull1_mskull morphology 1 (mouse)Not determined15799197791992080Mouse
1301225Sle7_msystematic lupus erythematosus susceptibility 7 (mouse)Not determined14685469080854839Mouse
1300841Ssial1_msusceptibility to sialadenitis 1 (mouse)Not determined163920002153557562Mouse
1357679Egrm1_mearly growth rate, maternal effect 1 (mouse)Not determined15799197791992080Mouse
4142467Wbcq1_mwhite blood cell quantitative locus 1 (mouse)Not determined15626621490266360Mouse
1301166Thypr2_mthymocyte proliferative response 2 (mouse)Not determined14127312475273271Mouse
1301933Insq6_minsulin QTL 6 (mouse)Not determined15672692290727077Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000053389   ⟹   ENSMUSP00000049714
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl174,230,944 - 74,233,790 (-)Ensembl
GRCm38.p6 Ensembl174,191,785 - 74,194,631 (-)Ensembl
Ensembl Acc Id: ENSMUST00000190313   ⟹   ENSMUSP00000139555
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl174,230,944 - 74,232,394 (-)Ensembl
GRCm38.p6 Ensembl174,191,785 - 74,193,235 (-)Ensembl
RefSeq Acc Id: NM_178241   ⟹   NP_839972
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39174,228,862 - 74,233,813 (-)NCBI
GRCm38174,191,785 - 74,194,631 (-)NCBI
MGSCv37174,238,359 - 74,241,205 (-)RGD
Celera174,753,154 - 74,755,998 (-)RGD
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006495956   ⟹   XP_006496019
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39174,230,944 - 74,232,003 (-)NCBI
GRCm38174,191,785 - 74,192,844 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030253700   ⟹   XP_030109560
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39174,230,962 - 74,233,867 (-)NCBI
GRCm38174,191,785 - 74,194,708 (-)NCBI
Sequence:
RefSeq Acc Id: NP_839972   ⟸   NM_178241
- UniProtKB: Q810W6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006496019   ⟸   XM_006495956
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_030109560   ⟸   XM_030253700
- Peptide Label: isoform X1
- UniProtKB: Q810W6 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSMUSP00000049714   ⟸   ENSMUST00000053389
Ensembl Acc Id: ENSMUSP00000139555   ⟸   ENSMUST00000190313
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q810W6-F1-model_v2 AlphaFold Q810W6 1-351 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2448715 AgrOrtholog
Ensembl Genes ENSMUSG00000048480 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000053389 ENTREZGENE
  ENSMUST00000053389.5 UniProtKB/Swiss-Prot
  ENSMUST00000190313 ENTREZGENE
  ENSMUST00000190313.2 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Chemokine_CXCR_1/2 UniProtKB/Swiss-Prot
  GPCR1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:227288 UniProtKB/Swiss-Prot
MGD MGI:2448715 ENTREZGENE
NCBI Gene 227288 ENTREZGENE
PANTHER C-X-C CHEMOKINE RECEPTOR TYPE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CELL ADHESION MOLECULE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cxcr1 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INTRLEUKIN8R UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CXCR1_MOUSE UniProtKB/Swiss-Prot
  Q5ZGW9_MOUSE UniProtKB/TrEMBL
  Q810W6 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-06-27 Cxcr1  C-X-C motif chemokine receptor 1  Cxcr1  chemokine (C-X-C motif) receptor 1  Symbol and/or name change 5135510 APPROVED