Havcr2 (hepatitis A virus cellular receptor 2) - Rat Genome Database

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Gene: Havcr2 (hepatitis A virus cellular receptor 2) Mus musculus
Analyze
Symbol: Havcr2
Name: hepatitis A virus cellular receptor 2
RGD ID: 1313141
MGI Page MGI
Description: Predicted to enable metal ion binding activity. Involved in several processes, including regulation of cytokine production; regulation of defense response; and regulation of leukocyte activation. Located in cell surface; early endosome; and immunological synapse. Is expressed in several structures, including aorta-gonad-mesonephros; gut; liver; lung; and reproductive system. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and renal cell carcinoma. Orthologous to human HAVCR2 (hepatitis A virus cellular receptor 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: HAVcr-2; hepatitis A virus cellular receptor 2 homolog; MGC124149; MGC124150; T-cell immunoglobulin and mucin domain containing 3; T-cell immunoglobulin and mucin domain-containing protein 3; T-cell immunoglobulin mucin receptor 3; T-cell membrane protein 3; Tim; TIM-; TIM-3; Tim3; Timd; TIMD-3; Timd3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391146,345,758 - 46,372,082 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1146,345,762 - 46,372,082 (+)EnsemblGRCm39 Ensembl
GRCm381146,454,931 - 46,481,255 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1146,454,935 - 46,481,255 (+)EnsemblGRCm38mm10GRCm38
MGSCv371146,268,433 - 46,294,757 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361146,298,358 - 46,324,678 (+)NCBIMGSCv36mm8
Celera1151,038,900 - 51,067,047 (+)NCBICelera
Cytogenetic Map11B1.1NCBI
cM Map1127.9NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adaptive immune response  (IEA)
cellular response to lipopolysaccharide  (IDA)
defense response to Gram-positive bacterium  (IMP)
immune system process  (IEA)
inflammatory response  (IEA)
innate immune response  (IEA)
macrophage activation involved in immune response  (IMP)
maternal process involved in female pregnancy  (IDA,ISO)
natural killer cell tolerance induction  (ISO)
negative regulation of defense response to bacterium  (IMP)
negative regulation of gene expression  (ISO)
negative regulation of granulocyte colony-stimulating factor production  (ISO)
negative regulation of immune response to tumor cell  (IMP)
negative regulation of immunological synapse formation  (IMP)
negative regulation of innate immune response  (IMP)
negative regulation of interferon-alpha production  (ISO)
negative regulation of interleukin-2 production  (IMP,ISO)
negative regulation of interleukin-3 production  (ISO)
negative regulation of interleukin-6 production  (IMP)
negative regulation of myeloid dendritic cell activation  (ISO)
negative regulation of natural killer cell activation  (IMP)
negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target  (IMP)
negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell  (ISO)
negative regulation of T cell proliferation  (IMP)
negative regulation of T-helper 1 type immune response  (IMP)
negative regulation of tumor necrosis factor production  (ISO)
negative regulation of type I interferon production  (IMP)
negative regulation of type II interferon production  (IMP,ISO)
positive regulation of chemokine production  (IMP)
positive regulation of cytokine production  (IMP)
positive regulation of defense response to bacterium  (IMP)
positive regulation of ERK1 and ERK2 cascade  (IDA)
positive regulation of innate immune response  (IMP)
positive regulation of interleukin-1 production  (IMP)
positive regulation of interleukin-4 production  (ISO)
positive regulation of macrophage activation  (IMP)
positive regulation of non-canonical NF-kappaB signal transduction  (IDA)
positive regulation of T cell proliferation  (IMP)
positive regulation of tumor necrosis factor production  (IMP,ISO)
positive regulation of type II interferon production  (IMP)
regulation of tolerance induction dependent upon immune response  (IMP)
regulation of transcription by RNA polymerase II  (IBA)
toll-like receptor 3 signaling pathway  (IMP)
toll-like receptor 7 signaling pathway  (IMP)
toll-like receptor 9 signaling pathway  (IMP)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. T-cell immunoglobulin- and mucin-domain-containing molecule 3 gene polymorphisms and renal cell carcinoma. Cai C, etal., DNA Cell Biol. 2012 Jul;31(7):1285-9. doi: 10.1089/dna.2012.1625. Epub 2012 Apr 3.
2. Expression of T cell immunoglobulin- and mucin-domain-containing molecules-1 and -3 (TIM-1 and -3) in the rat nervous and immune systems. Gielen AW, etal., J Neuroimmunol. 2005 Jul;164(1-2):93-104.
3. Association of atopy and eczema with polymorphisms in T-cell immunoglobulin domain and mucin domain-IL-2-inducible T-cell kinase gene cluster in chromosome 5 q 33. Graves PE, etal., J Allergy Clin Immunol. 2005 Sep;116(3):650-6.
4. Th2-driven, allergen-induced airway inflammation is reduced after treatment with anti-Tim-3 antibody in vivo. Kearley J, etal., J Exp Med. 2007 Jun 11;204(6):1289-94. Epub 2007 May 21.
5. Genetic polymorphisms of immune checkpoint proteins PD-1 and TIM-3 are associated with survival of patients with hepatitis B virus-related hepatocellular carcinoma. Li Z, etal., Oncotarget. 2016 May 3;7(18):26168-80. doi: 10.18632/oncotarget.8435.
6. Sequential monitoring of TIM-3 gene expression in peripheral blood for diagnostic and prognostic evaluation of acute rejection in renal graft recipients. Luo Y, etal., Transplant Proc. 2011 Dec;43(10):3669-74. doi: 10.1016/j.transproceed.2011.08.106.
7. MGDs mouse GO annotations MGD data from the GO Consortium
8. MGD IEA MGD IEA
9. Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. Monney L, etal., Nature. 2002 Jan 31;415(6871):536-41.
10. Regulation of osteoclastogenesis through Tim-3: possible involvement of the Tim-3/galectin-9 system in the modulation of inflammatory bone destruction. Moriyama K, etal., Lab Invest. 2014 Nov;94(11):1200-11. doi: 10.1038/labinvest.2014.107. Epub 2014 Sep 29.
11. Increased expression of Tim-3 and its ligand Galectin-9 in rat allografts during acute rejection episodes. Qiao X, etal., Biochem Biophys Res Commun. 2014 Mar 14;445(3):542-8. doi: 10.1016/j.bbrc.2014.01.167. Epub 2014 Feb 4.
12. Mouse MP Annotation Import Pipeline RGD automated import pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Dysregulation of TIM-3-galectin-9 pathway in the cystic fibrosis airways. Vega-Carrascal I, etal., J Immunol. 2011 Mar 1;186(5):2897-909. Epub 2011 Jan 24.
15. Elevated expression of Tim-3 on CD8 T cells correlates with disease severity of pulmonary tuberculosis. Wang X, etal., J Infect. 2011 Apr;62(4):292-300. Epub 2011 Mar 5.
16. Tim-3 cell signaling and iNOS are involved in the protective effects of ischemic postconditioning against focal ischemia in rats. Wei D, etal., Metab Brain Dis. 2014 Apr 29.
17. Distinct expression of Tim-3 during different stages of rat experimental autoimmune neuritis. Zhang ZY, etal., Brain Res Bull. 2011 Oct 10;86(3-4):229-34. doi: 10.1016/j.brainresbull.2011.07.005. Epub 2011 Jul 18.
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11725301   PMID:12466851   PMID:12477932   PMID:14556005   PMID:14556006   PMID:15514019   PMID:15989777   PMID:16141072  
PMID:16141073   PMID:16286920   PMID:16424168   PMID:16709797   PMID:16766398   PMID:17145500   PMID:17363302   PMID:17513715   PMID:17513880   PMID:17620455   PMID:17660555   PMID:18006747  
PMID:18346632   PMID:19017954   PMID:19224762   PMID:19234217   PMID:19254478   PMID:19362679   PMID:19905911   PMID:19913460   PMID:20049876   PMID:20083673   PMID:20133006   PMID:20167865  
PMID:20463811   PMID:20574007   PMID:20637206   PMID:20664975   PMID:20679213   PMID:20937702   PMID:20956339   PMID:21187321   PMID:21385853   PMID:21470319   PMID:21519864   PMID:21575348  
PMID:21677750   PMID:21858045   PMID:21873635   PMID:21923683   PMID:22021615   PMID:22038354   PMID:22168579   PMID:22438246   PMID:22677125   PMID:22684103   PMID:22842346   PMID:22863785  
PMID:22875804   PMID:23117395   PMID:23232962   PMID:23296703   PMID:23562810   PMID:23595213   PMID:23653017   PMID:23904364   PMID:23990206   PMID:24194600   PMID:24289479   PMID:24316337  
PMID:24333756   PMID:24337741   PMID:24486565   PMID:24561184   PMID:24567532   PMID:24945079   PMID:25065622   PMID:25172495   PMID:25270237   PMID:25337993   PMID:25363763   PMID:25450716  
PMID:25557503   PMID:25578313   PMID:25608525   PMID:25614966   PMID:25653440   PMID:25676534   PMID:25790768   PMID:25897749   PMID:25987707   PMID:26208474   PMID:26214042   PMID:26278059  
PMID:26403707   PMID:26561949   PMID:26598760   PMID:26750587   PMID:26890332   PMID:26967901   PMID:27209052   PMID:27439518   PMID:28205579   PMID:28253997   PMID:28331165   PMID:28686578  
PMID:28799242   PMID:28951537   PMID:29083087   PMID:29107214   PMID:29315553   PMID:29316433   PMID:29449693   PMID:29463725   PMID:29570768   PMID:29602251   PMID:29712685   PMID:29735977  
PMID:29844236   PMID:30622243   PMID:30763585   PMID:30862474   PMID:31162951   PMID:31329823   PMID:31351483   PMID:31354713   PMID:31586389   PMID:31676858   PMID:31711531   PMID:31733121  
PMID:31848194   PMID:32094297   PMID:32306409   PMID:32377751   PMID:33031600   PMID:33107565   PMID:33139903   PMID:33244787   PMID:33718261   PMID:33822811   PMID:33979578   PMID:33984607  
PMID:34053493   PMID:34108686   PMID:34110282   PMID:34223915   PMID:34525351   PMID:34968777   PMID:35095844   PMID:35550500   PMID:35715604   PMID:35777268   PMID:35980306   PMID:35997714  
PMID:36007392   PMID:36303229   PMID:36480166   PMID:36675047   PMID:36736642   PMID:36883358   PMID:37058540   PMID:37202419   PMID:37691941   PMID:37806131   PMID:37926471   PMID:38108417  
PMID:38330550  


Genomics

Comparative Map Data
Havcr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391146,345,758 - 46,372,082 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1146,345,762 - 46,372,082 (+)EnsemblGRCm39 Ensembl
GRCm381146,454,931 - 46,481,255 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1146,454,935 - 46,481,255 (+)EnsemblGRCm38mm10GRCm38
MGSCv371146,268,433 - 46,294,757 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361146,298,358 - 46,324,678 (+)NCBIMGSCv36mm8
Celera1151,038,900 - 51,067,047 (+)NCBICelera
Cytogenetic Map11B1.1NCBI
cM Map1127.9NCBI
HAVCR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385157,085,832 - 157,109,044 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5157,085,422 - 157,142,869 (-)EnsemblGRCh38hg38GRCh38
GRCh375156,512,843 - 156,536,055 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365156,445,421 - 156,468,716 (-)NCBINCBI36Build 36hg18NCBI36
Build 345156,445,420 - 156,468,716NCBI
Celera5152,539,374 - 152,562,664 (-)NCBICelera
Cytogenetic Map5q33.3NCBI
HuRef5151,601,069 - 151,624,237 (-)NCBIHuRef
CHM1_15155,945,610 - 155,968,997 (-)NCBICHM1_1
T2T-CHM13v2.05157,604,811 - 157,627,988 (-)NCBIT2T-CHM13v2.0
Havcr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81031,383,801 - 31,415,334 (+)NCBIGRCr8
mRatBN7.21030,882,484 - 30,914,018 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1030,882,606 - 30,909,137 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1035,610,204 - 35,636,731 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0104,148,656 - 4,175,185 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01030,585,018 - 30,612,066 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01031,561,838 - 31,590,624 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1031,561,895 - 31,588,943 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01031,376,989 - 31,404,231 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41031,585,703 - 31,610,825 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11031,579,175 - 31,610,030 (+)NCBI
Celera1030,333,452 - 30,358,912 (+)NCBICelera
Cytogenetic Map10q21NCBI
Havcr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540811,291,937 - 11,311,320 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540811,289,920 - 11,311,216 (-)NCBIChiLan1.0ChiLan1.0
HAVCR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24152,280,537 - 152,312,503 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15150,420,084 - 150,447,697 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05152,486,125 - 152,514,004 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15159,107,938 - 159,134,973 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5159,108,915 - 159,131,007 (-)Ensemblpanpan1.1panPan2
HAVCR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1453,018,990 - 53,032,035 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl453,012,234 - 53,033,393 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha452,911,200 - 52,924,236 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0453,440,445 - 53,471,049 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl453,455,568 - 53,500,924 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1453,281,860 - 53,294,897 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0453,388,880 - 53,401,897 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0453,905,760 - 53,918,797 (+)NCBIUU_Cfam_GSD_1.0
Havcr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213107,551,249 - 107,566,118 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365156,001,324 - 6,015,407 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HAVCR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1666,139,535 - 66,160,538 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11666,138,157 - 66,160,568 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21671,988,583 - 72,008,100 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HAVCR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12359,479,794 - 59,501,532 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2359,475,826 - 59,500,836 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603418,129,105 - 18,151,966 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Havcr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473332,521,318 - 32,527,499 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Havcr2
1039 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:962
Count of miRNA genes:370
Interacting mature miRNAs:403
Transcripts:ENSMUST00000020668, ENSMUST00000109229
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226798Scvln18_msacral vertebrae length 2, 16 week (mouse)11325000060690826Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11325000062890826Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
27226738Metcl11_mmetatarsal-calcaneal length 11, 10 week (mouse)11885000061390826Mouse
26884401Huml4_mhumerus length 4, 10 week (mouse)111155000068490826Mouse
27226762Feml21_mfemur length 21, 16 week (mouse)111175000065990826Mouse
1357640Orq2_movulation rate QTL 2 (mouse)Not determined111226863768500330Mouse
4141127W3q4_mweight 3 weeks QTL 4 (mouse)Not determined1226863768500330Mouse
4141470Egq4_mearly growth QTL 4 (mouse)Not determined1226863768500330Mouse
4142109W10q2_mweight 10 weeks QTL 2 (mouse)Not determined1226863768500330Mouse
4141582Lgaq1_mlate growth adjusted QTL 1 (mouse)Not determined1226863768500330Mouse
4142308W6q3_mweight 6 weeks QTL 3 (mouse)Not determined111226863768500330Mouse
4142216Lgq1_mlate growth QTL 1 (mouse)Not determined1226863768500330Mouse
4141966Tailq1_mtail length QTL 1 (mouse)Not determined1226863768500330Mouse
1357851Scfq3_msubcutaneous fat pad weight QTL 3 (mouse)Not determined111226863768500330Mouse
1357720Kidpq1_mkidney weight percentage QTL 1 (mouse)Not determined111226863768500330Mouse
1357437Epfq4_mepididymal fat pad weight QTL 4 (mouse)Not determined111226863768500330Mouse
1559002Lmrq4_mLeishmania major resistance QTL 4 (mouse)Not determined111226863769684947Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
1558945Orgwq8_morgan weight QTL 8 (mouse)Not determined111705617567078411Mouse
10053687Eae6_msusceptibility to experimental allergic encephalomyelitis 6 (mouse)Not determined111778196668500330Mouse
12801459Leuf1_mleukocyte filtration 1 (mouse)111857861652578716Mouse
12801460Intim2_mintima modifier 2 (mouse)111857861652578716Mouse
12801457Intmrm2_mintima/media ratio modifier 2 (mouse)111857861652578716Mouse
1300938Bulb3_mbulb size 3 (mouse)Not determined111857861652578716Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
1300579Thypr1_mthymocyte proliferative response 1 (mouse)Not determined111928257753282715Mouse
14746971Manh70_mmandible shape 70 (mouse)111990589053905890Mouse
4141398Tgq22_mtriglyceride QTL 22 (mouse)Not determined2116340655163406Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
10044006Hbnr13_mHeligmosomoides bakeri nematode resistance 13 (mouse)Not determined112577262659772741Mouse
12910801Pwbwq14_mpost-weaning body weight QTL 14 (mouse)112719805750636094Mouse
12910804Pwbwq16_mpost-weaning body weight QTL 16 (mouse)112719805750636094Mouse
12910806Pwbwq15_mpost-weaning body weight QTL 15 (mouse)112719805750636094Mouse
12910817Pwgrq20_mpost-weaning growth rate QTL 20 (mouse)112719805750636094Mouse
12910818Ogrq5_moverall growth rate QTL 5 (mouse)112719805750636094Mouse
1357844Si5lq5_mserum IGFBP-5 level QTL 5 (mouse)Not determined112816587362165976Mouse
13524848Ppiq7_mprepulse inhibition QTL 7 (mouse)112856914762569147Mouse
1301426Desp2_mdespair 2 (mouse)Not determined112870858162708700Mouse
11522752Cocia18_mcocaine-induced activity, QTL 18 (mouse)113100820965008209Mouse
11059563Lmr31_mleishmaniasis resistance 31 (mouse)113210057766100694Mouse
1357782Char8_mP. chabaudi malaria resistance QTL 8 (mouse)Not determined113557861669684987Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113589082784890826Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113628257783481356Mouse
1301788Lbw8_mlupus NZB x NZW 8 (mouse)Not determined113650328770509492Mouse
1301896Tria1_mT-cell receptor induced activation 1 (mouse)Not determined113661356570613855Mouse
4141853Skmw17_mskeletal muscle weight 17 (mouse)Not determined113708094171081064Mouse
4142475Ity2a_mimmunity to S. typhimurium 2a (mouse)Not determined113776858060402716Mouse
10766457Nwa3_mNew Zealand White autoimmunity 3 (mouse)113801611572016209Mouse
10053675Eae44b_mexperimental allergic encephalomyelitis susceptibility 44b (mouse)Not determined113995072854094448Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114225661776256730Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114225661776256730Mouse
1300713Vmbic10_mventral midbrain iron content 10 (mouse)Not determined114277262654081064Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114463003876854757Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114516587379978324Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114570858189818733Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114618516780185262Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114631940780319522Mouse

Markers in Region
Havcr2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381146,480,536 - 46,480,900UniSTSGRCm38
MGSCv371146,294,038 - 46,294,402UniSTSGRCm37
Celera1151,066,328 - 51,066,692UniSTS
Cytogenetic Map11B1.1UniSTS
cM Map11 UniSTS
Havcr2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11B1.1UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000020668   ⟹   ENSMUSP00000020668
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1146,345,762 - 46,372,082 (+)Ensembl
GRCm38.p6 Ensembl1146,454,935 - 46,481,255 (+)Ensembl
RefSeq Acc Id: ENSMUST00000109229   ⟹   ENSMUSP00000104852
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1146,345,796 - 46,372,073 (+)Ensembl
GRCm38.p6 Ensembl1146,454,969 - 46,481,246 (+)Ensembl
RefSeq Acc Id: NM_134250   ⟹   NP_599011
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391146,345,758 - 46,372,082 (+)NCBI
GRCm381146,454,931 - 46,481,255 (+)NCBI
MGSCv371146,268,433 - 46,294,757 (+)RGD
Celera1151,038,900 - 51,067,047 (+)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_599011   ⟸   NM_134250
- Peptide Label: precursor
- UniProtKB: Q8VIM0 (UniProtKB/Swiss-Prot),   Q3KP82 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000020668   ⟸   ENSMUST00000020668
RefSeq Acc Id: ENSMUSP00000104852   ⟸   ENSMUST00000109229
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8VIM0-F1-model_v2 AlphaFold Q8VIM0 1-281 view protein structure

Promoters
RGD ID:6821043
Promoter ID:MM_KWN:7104
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour
Transcripts:ENSMUST00000109229,   OTTMUST00000012247,   UC007ION.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361146,268,136 - 46,268,636 (+)MPROMDB
RGD ID:8674408
Promoter ID:EPDNEW_M15235
Type:initiation region
Name:Havcr2_1
Description:Mus musculus hepatitis A virus cellular receptor 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381146,454,967 - 46,455,027EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2159682 AgrOrtholog
Ensembl Genes ENSMUSG00000020399 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000020668 ENTREZGENE
  ENSMUST00000020668.15 UniProtKB/Swiss-Prot
  ENSMUST00000109229.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_V-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:171285 UniProtKB/Swiss-Prot
MGD MGI:2159682 ENTREZGENE
NCBI Gene 171285 ENTREZGENE
PANTHER HEPATITIS A VIRUS CELLULAR RECEPTOR 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  T-CELL IMMUNOGLOBULIN AND MUCIN DOMAIN CONTAINING TIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam V-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Havcr2 PhenoGen
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D3Z3I4_MOUSE UniProtKB/TrEMBL
  HAVR2_MOUSE UniProtKB/Swiss-Prot
  Q3KP82 ENTREZGENE, UniProtKB/TrEMBL
  Q8VIM0 ENTREZGENE