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RGD uses the Human Disease Ontology (DO, for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Primary Graft Dysfunction
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Accession:DOID:9006709 term browser browse the term
Definition:A form of ischemia-reperfusion injury occurring in the early period following transplantation. Significant pathophysiological changes in MITOCHONDRIA are the main cause of the dysfunction. It is most often seen in the transplanted lung, liver, or kidney and can lead to GRAFT REJECTION.
Synonyms:primary_id: MESH:D055031;   RDO:0007696
For additional species annotation, visit the Alliance of Genome Resources.

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Primary Graft Dysfunction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccn2 cellular communication network factor 2 exacerbates IEP protein:increased expression:urine (rat) RGD PMID:19921985 RGD:150517553 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Cd40lg CD40 ligand treatment ISO RGD PMID:12244161 RGD:7248713 NCBI chr  X:135,127,119...135,138,302
Ensembl chr  X:135,126,969...135,138,306
JBrowse link
G Gata2 GATA binding protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28569748 NCBI chr 4:120,654,205...120,667,763
Ensembl chr 4:120,658,986...120,667,761
JBrowse link
G Icam1 intercellular adhesion molecule 1 treatment IMP RGD PMID:22617707 PMID:10666412 RGD:8547722, RGD:11520779 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Il10 interleukin 10 treatment IDA RGD PMID:21911153 RGD:11049478 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Npy neuropeptide Y IEP mRNA, protein:decreased expression:blood, mononuclear cell RGD PMID:18981110 RGD:10448956 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
JBrowse link
G Selp selectin P ISO CTD Direct Evidence: marker/mechanism CTD PMID:28569748 NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845
JBrowse link
G Senp1 SUMO specific peptidase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28569748 NCBI chr 7:129,163,173...129,226,766
Ensembl chr 7:129,165,774...129,221,598
JBrowse link
G Tnf tumor necrosis factor treatment IEP liver RGD PMID:18972563 RGD:15023490 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28569748 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18109
    disease of anatomical entity 17480
      immune system disease 4479
        Transplant Rejection 117
          Primary Graft Dysfunction 10
Path 2
Term Annotations click to browse term
  disease 18109
    disease of anatomical entity 17480
      cardiovascular system disease 4822
        vascular disease 3604
          ischemia 1326
            Reperfusion Injury 723
              Primary Graft Dysfunction 10
paths to the root