CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: diclofenac
Accession: CHEBI:47381
browse the term
Definition: A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
Synonyms: exact_synonym: {2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid
related_synonym: 2-[2,6-DICHLOROPHENYL)AMINO]BENZENEACETIC ACID; Formula=C14H11Cl2NO2; InChI=1S/C14H11Cl2NO2/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19/h1-7,17H,8H2,(H,18,19); InChIKey=DCOPUUMXTXDBNB-UHFFFAOYSA-N; SMILES=C1(Cl)=CC=CC(=C1NC2=CC=CC=C2CC(=O)O)Cl; [2-(2,6-dichloroanilino)phenyl]acetic acid; diclofenac acid; diclofenaco; diclofenacum; diclofenamic acid
alt_id: CHEBI:4507; CHEBI:47380
xref: Beilstein:2146636; CAS:15307-86-5; DrugBank:DB00586; Drug_Central:865; HMDB:HMDB0014724; KEGG:C01690; KEGG:D07816; LINCS:LSM-2160
xref_mesh: MESH:D004008
xref: PDBeChem:DIF; PMID:11322639; PMID:1502708; PMID:23777257; PMID:27967303; PMID:7838674; Patent:NL6604752; Patent:US3558690; Reaxys:2146636; VSDB:1933; Wikipedia:Diclofenac
cyclic_relationship: is_conjugate_acid_of CHEBI:48311
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A2M
alpha-2-macroglobulin
increases expression
ISO
Diclofenac results in increased expression of A2M mRNA
CTD
PMID:26934552
NCBI chr12:9,067,708...9,116,229
Ensembl chr12:9,067,664...9,116,229
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AACS
acetoacetyl-CoA synthetase
decreases expression
ISO
Diclofenac results in decreased expression of AACS mRNA
CTD
PMID:26934552
NCBI chr12:125,065,435...125,143,316
Ensembl chr12:125,065,434...125,143,333
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AARS1
alanyl-tRNA synthetase 1
decreases expression
ISO
Diclofenac results in decreased expression of AARS1 mRNA
CTD
PMID:35537566
NCBI chr16:70,252,298...70,289,506
Ensembl chr16:70,251,983...70,289,707
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ABCB1
ATP binding cassette subfamily B member 1
decreases activity increases expression decreases response to substance
ISO EXP
Diclofenac results in decreased activity of ABCB1A protein Diclofenac results in increased expression of ABCB1B mRNA ABCB1A gene mutant form results in decreased susceptibility to Diclofenac
CTD
PMID:15458769 PMID:19022234 PMID:28193520
NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
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ABCB11
ATP binding cassette subfamily B member 11
multiple interactions decreases activity
EXP
Diclofenac inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid] Diclofenac results in decreased activity of ABCB11 protein
CTD
PMID:24014644 PMID:28437613
NCBI chr 2:168,915,390...169,031,324
Ensembl chr 2:168,915,498...169,031,324
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ABCB4
ATP binding cassette subfamily B member 4
decreases expression decreases activity
EXP
Diclofenac results in decreased expression of ABCB4 mRNA Diclofenac results in decreased activity of ABCB4 protein
CTD
PMID:19022234 PMID:28437613
NCBI chr 7:87,365,896...87,476,027
Ensembl chr 7:87,401,696...87,480,435
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ABCC2
ATP binding cassette subfamily C member 2
decreases activity multiple interactions increases expression
EXP ISO
Diclofenac results in decreased activity of ABCC2 protein ABCC2 protein results in increased transport of and results in increased metabolism of and results in increased susceptibility to Diclofenac Diclofenac results in increased expression of ABCC2 mRNA
CTD
PMID:19022234 PMID:22646477 PMID:25450747
NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594
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ABCC4
ATP binding cassette subfamily C member 4 (PEL blood group)
affects expression
EXP
Diclofenac affects the expression of ABCC4 mRNA
CTD
PMID:24752500
NCBI chr13:95,019,835...95,301,451
Ensembl chr13:95,019,835...95,301,475
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ABL2
ABL proto-oncogene 2, non-receptor tyrosine kinase
affects expression
EXP
Diclofenac affects the expression of ABL2 mRNA
CTD
PMID:24752500
NCBI chr 1:179,099,330...179,229,677
Ensembl chr 1:179,099,330...179,229,684
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AC024940.1
ovostatin 2
increases expression
ISO
Diclofenac results in increased expression of A2ML1 mRNA
CTD
PMID:26934552
NCBI chr12:31,111,652...31,201,235
Ensembl chr12:31,111,652...31,201,235
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ACE2
angiotensin converting enzyme 2
decreases expression
EXP
Diclofenac results in decreased expression of ACE2 mRNA
CTD
PMID:32808185
NCBI chr X:15,518,197...15,607,211
Ensembl chr X:15,494,566...15,607,236
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ACIN1
apoptotic chromatin condensation inducer 1
affects expression
EXP
Diclofenac affects the expression of ACIN1 mRNA
CTD
PMID:24752500
NCBI chr14:23,058,564...23,095,614
Ensembl chr14:23,058,564...23,095,614
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ACKR3
atypical chemokine receptor 3
decreases expression
EXP
Diclofenac results in decreased expression of ACKR3 mRNA
CTD
PMID:19192274
NCBI chr 2:236,537,122...236,582,354
Ensembl chr 2:236,567,787...236,582,354
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ACOT2
acyl-CoA thioesterase 2
decreases expression
ISO
Diclofenac results in decreased expression of ACOT2 mRNA
CTD
PMID:26934552
NCBI chr14:73,567,620...73,575,658
Ensembl chr14:73,567,620...73,575,658
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ACOX1
acyl-CoA oxidase 1
increases expression
ISO
Diclofenac results in increased expression of ACOX1 mRNA
CTD
PMID:19022234
NCBI chr17:75,941,507...75,979,166
Ensembl chr17:75,941,507...75,979,177
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ACP3
acid phosphatase 3
increases expression
ISO
Diclofenac results in increased expression of ACP3 mRNA
CTD
PMID:26934552
NCBI chr 3:132,317,407...132,368,302
Ensembl chr 3:132,317,369...132,368,302
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ACTA1
actin alpha 1, skeletal muscle
affects expression
EXP
Diclofenac affects the expression of ACTA1 mRNA
CTD
PMID:24752500
NCBI chr 1:229,431,245...229,434,094
Ensembl chr 1:229,430,365...229,434,104
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ACTN1
actinin alpha 1
affects expression
ISO
Diclofenac affects the expression of ACTN1 mRNA
CTD
PMID:19022234
NCBI chr14:68,874,128...68,979,302
Ensembl chr14:68,874,128...68,979,440
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ACVR1
activin A receptor type 1
affects expression
EXP
Diclofenac affects the expression of ACVR1 mRNA
CTD
PMID:24752500
NCBI chr 2:157,736,446...157,876,330
Ensembl chr 2:157,736,251...157,876,330
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ACVR1B
activin A receptor type 1B
affects expression
EXP
Diclofenac affects the expression of ACVR1B mRNA
CTD
PMID:24752500
NCBI chr12:51,951,699...51,997,078
Ensembl chr12:51,951,699...51,997,078
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ACVR2B
activin A receptor type 2B
affects expression
EXP
Diclofenac affects the expression of ACVR2B mRNA
CTD
PMID:24752500
NCBI chr 3:38,453,890...38,493,142
Ensembl chr 3:38,453,890...38,493,142
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ADAMDEC1
ADAM like decysin 1
increases expression
ISO
Diclofenac results in increased expression of ADAMDEC1 mRNA
CTD
PMID:26934552
NCBI chr 8:24,384,285...24,406,013
Ensembl chr 8:24,384,285...24,406,013
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ADCY6
adenylate cyclase 6
affects expression
EXP
Diclofenac affects the expression of ADCY6 mRNA
CTD
PMID:24752500
NCBI chr12:48,766,194...48,789,974
Ensembl chr12:48,766,194...48,789,089
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ADCY9
adenylate cyclase 9
affects expression decreases expression
EXP ISO
Diclofenac affects the expression of ADCY9 mRNA Diclofenac results in decreased expression of ADCY9 mRNA
CTD
PMID:24752500 PMID:26934552
NCBI chr16:3,953,387...4,116,442
Ensembl chr16:3,953,387...4,116,442
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ADH1C
alcohol dehydrogenase 1C (class I), gamma polypeptide
increases expression
ISO
Diclofenac results in increased expression of ADH1 protein
CTD
PMID:25772430
NCBI chr 4:99,336,497...99,352,746
Ensembl chr 4:99,336,497...99,352,746
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ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
decreases expression
ISO
Diclofenac results in decreased expression of ADH7 mRNA
CTD
PMID:35537566
NCBI chr 4:99,412,263...99,435,342
Ensembl chr 4:99,412,261...99,435,510
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ADK
adenosine kinase
increases expression decreases expression
EXP ISO
Diclofenac results in increased expression of ADK mRNA Diclofenac results in decreased expression of ADK mRNA
CTD
PMID:19022234
NCBI chr10:74,151,221...74,709,290
Ensembl chr10:74,151,202...74,709,963
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ADORA2A
adenosine A2a receptor
increases expression
ISO
Diclofenac results in increased expression of ADORA2A mRNA
CTD
PMID:26934552
NCBI chr22:24,423,597...24,442,357
Ensembl chr22:24,417,879...24,442,357
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ADORA2B
adenosine A2b receptor
increases expression
ISO
Diclofenac results in increased expression of ADORA2B mRNA
CTD
PMID:26934552
NCBI chr17:15,850,362...15,975,746
Ensembl chr17:15,945,130...15,975,746
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ADRB2
adrenoceptor beta 2
increases expression
ISO
Diclofenac results in increased expression of ADRB2 mRNA
CTD
PMID:26934552
NCBI chr 5:148,826,611...148,828,623
Ensembl chr 5:148,826,611...148,828,623
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AEN
apoptosis enhancing nuclease
increases expression
ISO
Diclofenac results in increased expression of AEN mRNA
CTD
PMID:35537566
NCBI chr15:88,604,683...88,632,281
Ensembl chr15:88,621,337...88,632,281
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AGER
advanced glycosylation end-product specific receptor
increases expression
ISO EXP
Diclofenac results in increased expression of AGER mRNA
CTD
PMID:24747151 PMID:28138970
NCBI chr 6:32,180,969...32,184,253
Ensembl chr 6:32,180,968...32,184,322
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AGGF1
angiogenic factor with G-patch and FHA domains 1
affects expression
EXP
Diclofenac affects the expression of AGGF1 mRNA
CTD
PMID:24752500
NCBI chr 5:77,030,404...77,065,234
Ensembl chr 5:77,029,251...77,065,234
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AGO2
argonaute RISC catalytic component 2
affects expression
EXP
Diclofenac affects the expression of AGO2 mRNA
CTD
PMID:24752500
NCBI chr 8:140,520,156...140,642,313
Ensembl chr 8:140,520,156...140,635,633
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AGO3
argonaute RISC catalytic component 3
affects expression
EXP
Diclofenac affects the expression of AGO3 mRNA
CTD
PMID:24752500
NCBI chr 1:35,930,718...36,072,500
Ensembl chr 1:35,930,718...36,072,500
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AGO4
argonaute RISC component 4
affects expression
EXP
Diclofenac affects the expression of AGO4 mRNA
CTD
PMID:24752500
NCBI chr 1:35,807,636...35,857,890
Ensembl chr 1:35,808,016...35,857,890
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AGRP
agouti related neuropeptide
increases expression
ISO
Diclofenac results in increased expression of AGRP mRNA
CTD
PMID:30723492
NCBI chr16:67,482,571...67,483,547
Ensembl chr16:67,482,571...67,483,547
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AHR
aryl hydrocarbon receptor
increases expression
ISO
Diclofenac results in increased expression of AHR mRNA
CTD
PMID:26934552
NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
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AHSG
alpha 2-HS glycoprotein
multiple interactions
ISO
[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of AHSG protein
CTD
PMID:25772430
NCBI chr 3:186,613,060...186,621,318
Ensembl chr 3:186,613,060...186,621,318
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AIFM1
apoptosis inducing factor mitochondria associated 1
affects expression
EXP
Diclofenac affects the expression of AIFM1 mRNA
CTD
PMID:24752500
NCBI chr X:130,129,362...130,165,841
Ensembl chr X:130,124,666...130,165,879
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AIM2
absent in melanoma 2
increases expression
ISO
Diclofenac results in increased expression of AIM2 mRNA
CTD
PMID:26934552
NCBI chr 1:159,055,051...159,147,132
Ensembl chr 1:159,061,599...159,187,843
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AKNA
AT-hook transcription factor
decreases expression
ISO
Diclofenac results in decreased expression of AKNA mRNA
CTD
PMID:35537566
NCBI chr 9:114,330,504...114,398,472
Ensembl chr 9:114,334,156...114,394,405
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AKT1
AKT serine/threonine kinase 1
affects expression
EXP
Diclofenac affects the expression of AKT1 mRNA
CTD
PMID:24752500
NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,759
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AKT2
AKT serine/threonine kinase 2
affects expression
EXP
Diclofenac affects the expression of AKT2 mRNA
CTD
PMID:24752500
NCBI chr19:40,230,317...40,285,345
Ensembl chr19:40,230,317...40,285,536
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ALAS1
5'-aminolevulinate synthase 1
decreases expression
ISO
Diclofenac results in decreased expression of ALAS1 mRNA
CTD
PMID:26934552
NCBI chr 3:52,198,083...52,214,327
Ensembl chr 3:52,198,086...52,214,327
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ALAS2
5'-aminolevulinate synthase 2
affects expression
EXP
Diclofenac affects the expression of ALAS2 mRNA
CTD
PMID:24752500
NCBI chr X:55,009,055...55,030,977
Ensembl chr X:55,009,055...55,030,977
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ALB
albumin
affects binding decreases secretion multiple interactions decreases expression increases expression
EXP ISO
Diclofenac binds to ALB protein Diclofenac results in decreased secretion of ALB protein [Ranitidine co-treated with Diclofenac] results in decreased expression of ALB protein; Quercetin inhibits the reaction [[Ranitidine co-treated with Diclofenac] results in decreased expression of ALB protein] Diclofenac results in decreased expression of ALB protein Diclofenac results in increased expression of ALB mRNA
CTD
PMID:9353694 PMID:19022234 PMID:28400101 PMID:36442613
NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482
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ALDH18A1
aldehyde dehydrogenase 18 family member A1
increases expression decreases expression
ISO
Diclofenac results in increased expression of ALDH18A1 mRNA Diclofenac results in decreased expression of ALDH18A1 mRNA
CTD
PMID:26934552 PMID:35537566
NCBI chr10:95,605,941...95,656,711
Ensembl chr10:95,605,941...95,656,711
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ALDH1B1
aldehyde dehydrogenase 1 family member B1
increases expression
ISO
Diclofenac results in increased expression of ALDH1B1 mRNA
CTD
PMID:26934552
NCBI chr 9:38,392,702...38,398,661
Ensembl chr 9:38,392,702...38,398,661
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ALDH1L2
aldehyde dehydrogenase 1 family member L2
decreases expression
ISO
Diclofenac results in decreased expression of ALDH1L2 mRNA
CTD
PMID:26934552
NCBI chr12:105,019,790...105,084,458
Ensembl chr12:105,019,784...105,107,643
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ALDH3A2
aldehyde dehydrogenase 3 family member A2
decreases expression
ISO
Diclofenac results in decreased expression of ALDH3A2 mRNA
CTD
PMID:26934552
NCBI chr17:19,648,136...19,677,596
Ensembl chr17:19,648,136...19,685,760
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ALDOC
aldolase, fructose-bisphosphate C
increases expression
ISO
Diclofenac results in increased expression of ALDOC mRNA
CTD
PMID:30723492
NCBI chr17:28,573,120...28,576,895
Ensembl chr17:28,573,115...28,576,948
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ALOX15
arachidonate 15-lipoxygenase
increases expression
ISO
Diclofenac results in increased expression of ALOX15 mRNA
CTD
PMID:23939143
NCBI chr17:4,630,919...4,641,678
Ensembl chr17:4,630,919...4,642,294
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AMH
anti-Mullerian hormone
increases expression
ISO
Diclofenac results in increased expression of AMH mRNA
CTD
PMID:35537566
NCBI chr19:2,249,323...2,252,073
Ensembl chr19:2,249,309...2,252,073
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AMOTL2
angiomotin like 2
decreases expression
ISO
Diclofenac results in decreased expression of AMOTL2 mRNA
CTD
PMID:35537566
NCBI chr 3:134,355,345...134,375,417
Ensembl chr 3:134,355,347...134,375,479
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ANG
angiogenin
increases expression
ISO
Diclofenac results in increased expression of ANG mRNA
CTD
PMID:26934552
NCBI chr14:20,684,177...20,694,186
Ensembl chr14:20,684,177...20,698,971
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AOC3
amine oxidase copper containing 3
decreases expression
ISO
Diclofenac results in decreased expression of AOC3 mRNA
CTD
PMID:26934552
NCBI chr17:42,851,199...42,858,124
Ensembl chr17:42,851,184...42,858,130
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APAF1
apoptotic peptidase activating factor 1
affects expression
EXP
Diclofenac affects the expression of APAF1 mRNA
CTD
PMID:24752500
NCBI chr12:98,645,290...98,735,433
Ensembl chr12:98,645,149...98,735,433
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APCS
amyloid P component, serum
multiple interactions increases expression
ISO
[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of APCS protein Diclofenac results in increased expression of APCS mRNA; Diclofenac results in increased expression of APCS protein
CTD
PMID:25772430 PMID:26934552
NCBI chr 1:159,587,826...159,588,865
Ensembl chr 1:159,587,826...159,588,865
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APOA4
apolipoprotein A4
affects expression
ISO
Diclofenac affects the expression of APOA4 mRNA
CTD
PMID:26934552
NCBI chr11:116,820,700...116,823,304
Ensembl chr11:116,820,700...116,823,304
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AQP2
aquaporin 2
decreases expression
ISO
Diclofenac results in decreased expression of AQP2 protein
CTD
PMID:15579502
NCBI chr12:49,950,737...49,958,878
Ensembl chr12:49,950,737...49,958,878
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AQP9
aquaporin 9
decreases expression
ISO
Diclofenac results in decreased expression of AQP9 mRNA
CTD
PMID:35537566
NCBI chr15:58,138,169...58,185,911
Ensembl chr15:58,138,169...58,185,911
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AQR
aquarius intron-binding spliceosomal factor
affects expression
EXP
Diclofenac affects the expression of AQR mRNA
CTD
PMID:24752500
NCBI chr15:34,851,782...34,969,742
Ensembl chr15:34,851,782...34,969,742
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AR
androgen receptor
affects activity
EXP
Diclofenac affects the activity of AR protein
CTD
PMID:29777833
NCBI chr X:67,544,021...67,730,619
Ensembl chr X:67,544,021...67,730,619
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ARAF
A-Raf proto-oncogene, serine/threonine kinase
affects expression
EXP
Diclofenac affects the expression of ARAF mRNA
CTD
PMID:24752500
NCBI chr X:47,561,205...47,571,908
Ensembl chr X:47,561,205...47,571,908
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ARHGAP20
Rho GTPase activating protein 20
increases expression
ISO
Diclofenac results in increased expression of ARHGAP20 mRNA
CTD
PMID:30723492
NCBI chr11:110,577,043...110,713,189
Ensembl chr11:110,577,042...110,713,189
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ARHGAP26
Rho GTPase activating protein 26
affects expression
EXP
Diclofenac affects the expression of ARHGAP26 mRNA
CTD
PMID:24752500
NCBI chr 5:142,770,377...143,229,011
Ensembl chr 5:142,770,377...143,229,011
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ARHGEF2
Rho/Rac guanine nucleotide exchange factor 2
affects expression
EXP
Diclofenac affects the expression of ARHGEF2 mRNA
CTD
PMID:24752500
NCBI chr 1:155,946,854...155,979,617
Ensembl chr 1:155,946,851...156,007,070
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ARHGEF3
Rho guanine nucleotide exchange factor 3
affects expression decreases expression
EXP ISO
Diclofenac affects the expression of ARHGEF3 mRNA Diclofenac results in decreased expression of ARHGEF3 mRNA
CTD
PMID:24752500 PMID:35537566
NCBI chr 3:56,727,420...57,079,268
Ensembl chr 3:56,727,418...57,079,329
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ARHGEF7
Rho guanine nucleotide exchange factor 7
affects expression
EXP
Diclofenac affects the expression of ARHGEF7 mRNA
CTD
PMID:24752500
NCBI chr13:111,114,619...111,305,734
Ensembl chr13:111,114,559...111,305,737
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ARID5A
AT-rich interaction domain 5A
decreases expression
ISO
Diclofenac results in decreased expression of ARID5A mRNA
CTD
PMID:35537566
NCBI chr 2:96,536,752...96,552,638
Ensembl chr 2:96,536,743...96,552,634
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ARID5B
AT-rich interaction domain 5B
decreases expression
ISO
Diclofenac results in decreased expression of ARID5B mRNA
CTD
PMID:26934552
NCBI chr10:61,901,699...62,096,944
Ensembl chr10:61,901,684...62,096,944
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ARL11
ADP ribosylation factor like GTPase 11
decreases expression
ISO
Diclofenac results in decreased expression of ARL11 mRNA
CTD
PMID:35537566
NCBI chr13:49,628,507...49,633,872
Ensembl chr13:49,628,507...49,633,872
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ARMCX1
armadillo repeat containing X-linked 1
increases expression
ISO
Diclofenac results in increased expression of ARMCX1 mRNA
CTD
PMID:30723492
NCBI chr X:101,550,547...101,554,700
Ensembl chr X:101,550,547...101,554,700
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ARNT
aryl hydrocarbon receptor nuclear translocator
affects expression
EXP
Diclofenac affects the expression of ARNT mRNA
CTD
PMID:24752500
NCBI chr 1:150,809,713...150,876,599
Ensembl chr 1:150,809,713...150,876,708
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ARRDC3
arrestin domain containing 3
increases expression
ISO
Diclofenac results in increased expression of ARRDC3 mRNA
CTD
PMID:35537566
NCBI chr 5:91,368,631...91,383,317
Ensembl chr 5:91,368,631...91,383,317
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ASAP1
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
affects expression
EXP
Diclofenac affects the expression of ASAP1 mRNA
CTD
PMID:24752500
NCBI chr 8:130,052,104...130,443,674
Ensembl chr 8:130,052,104...130,443,674
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ASH2L
ASH2 like, histone lysine methyltransferase complex subunit
affects expression
EXP
Diclofenac affects the expression of ASH2L mRNA
CTD
PMID:24752500
NCBI chr 8:38,105,493...38,140,080
Ensembl chr 8:38,105,493...38,144,076
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ASIC1
acid sensing ion channel subunit 1
decreases expression
ISO
Diclofenac results in decreased expression of ASIC1 mRNA
CTD
PMID:11588175
NCBI chr12:50,057,596...50,083,622
Ensembl chr12:50,057,548...50,083,611
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ASIC2
acid sensing ion channel subunit 2
decreases expression
ISO
Diclofenac results in decreased expression of ASIC2 mRNA
CTD
PMID:11588175
NCBI chr17:33,013,087...34,156,768
Ensembl chr17:33,013,087...34,174,964
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ASIC3
acid sensing ion channel subunit 3
decreases expression decreases activity
ISO
Diclofenac results in decreased expression of ASIC3 mRNA Diclofenac results in decreased activity of ASIC3 protein
CTD
PMID:11588175
NCBI chr 7:151,048,292...151,052,756
Ensembl chr 7:151,048,292...151,052,756
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ASL
argininosuccinate lyase
affects expression
EXP
Diclofenac affects the expression of ASL mRNA
CTD
PMID:24752500
NCBI chr 7:66,075,819...66,093,576
Ensembl chr 7:66,075,800...66,094,697
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ASNS
asparagine synthetase (glutamine-hydrolyzing)
decreases expression increases expression
EXP ISO
Diclofenac results in decreased expression of ASNS mRNA Diclofenac results in increased expression of ASNS mRNA
CTD
PMID:19192274 PMID:26934552 PMID:35537566
NCBI chr 7:97,851,677...97,928,441
Ensembl chr 7:97,851,677...97,872,542
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ASS1
argininosuccinate synthase 1
decreases expression
ISO
Diclofenac results in decreased expression of ASS1 mRNA
CTD
PMID:26934552
NCBI chr 9:130,444,707...130,501,274
Ensembl chr 9:130,444,961...130,501,274
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ATF2
activating transcription factor 2
affects expression
EXP
Diclofenac affects the expression of ATF2 mRNA
CTD
PMID:24752500
NCBI chr 2:175,072,259...175,168,203
Ensembl chr 2:175,072,250...175,168,382
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ATF4
activating transcription factor 4
affects expression decreases expression increases expression
EXP ISO
Diclofenac affects the expression of ATF4 mRNA Diclofenac results in decreased expression of ATF4 mRNA Diclofenac results in increased expression of ATF4 mRNA
CTD
PMID:24752500 PMID:27313093 PMID:35537566
NCBI chr22:39,520,559...39,522,686
Ensembl chr22:39,519,695...39,522,683
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ATF5
activating transcription factor 5
decreases expression
ISO
Diclofenac results in decreased expression of ATF5 mRNA
CTD
PMID:35537566
NCBI chr19:49,928,906...49,933,935
Ensembl chr19:49,928,702...49,933,935
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ATP11A
ATPase phospholipid transporting 11A
increases expression
ISO
Diclofenac results in increased expression of ATP11A mRNA
CTD
PMID:26934552
NCBI chr13:112,690,038...112,887,168
Ensembl chr13:112,690,038...112,887,168
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ATP5F1A
ATP synthase F1 subunit alpha
multiple interactions increases expression
ISO
[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of ATP5F1A protein Diclofenac results in increased expression of ATP5F1A protein
CTD
PMID:25772430
NCBI chr18:46,080,248...46,104,227
Ensembl chr18:46,080,248...46,104,334
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ATP5F1B
ATP synthase F1 subunit beta
multiple interactions increases expression
ISO
[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of ATP5F1B protein Diclofenac results in increased expression of ATP5F1B protein
CTD
PMID:25772430
NCBI chr12:56,638,175...56,645,984
Ensembl chr12:56,638,175...56,645,984
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ATP5PF
ATP synthase peripheral stalk subunit F6
multiple interactions increases expression
ISO
[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of ATP5PF protein Diclofenac results in increased expression of ATP5PF protein
CTD
PMID:25772430
NCBI chr21:25,724,500...25,735,653
Ensembl chr21:25,716,503...25,735,673
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AZIN1
antizyme inhibitor 1
affects expression
EXP
Diclofenac affects the expression of AZIN1 mRNA
CTD
PMID:24752500
NCBI chr 8:102,826,302...102,864,200
Ensembl chr 8:102,826,111...102,893,864
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B3GALT1
beta-1,3-galactosyltransferase 1
increases expression
ISO
Diclofenac results in increased expression of B3GALT1 mRNA
CTD
PMID:26934552
NCBI chr 2:167,293,001...167,874,045
Ensembl chr 2:167,293,001...167,874,045
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BACH1
BTB domain and CNC homolog 1
affects expression
EXP
Diclofenac affects the expression of BACH1 mRNA
CTD
PMID:24752500
NCBI chr21:29,298,922...29,361,894
Ensembl chr21:29,194,071...29,630,751
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BAK1
BCL2 antagonist/killer 1
increases activity
EXP
Diclofenac results in increased activity of BAK1 protein
CTD
PMID:18191430
NCBI chr 6:33,572,552...33,580,276
Ensembl chr 6:33,572,547...33,580,293
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BARD1
BRCA1 associated RING domain 1
affects expression
EXP
Diclofenac affects the expression of BARD1 mRNA
CTD
PMID:24752500
NCBI chr 2:214,725,646...214,809,683
Ensembl chr 2:214,725,646...214,809,683
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BAX
BCL2 associated X, apoptosis regulator
increases activity affects localization increases expression
EXP ISO
Diclofenac results in increased activity of BAX protein Diclofenac affects the localization of BAX protein Diclofenac results in increased expression of BAX mRNA
CTD
PMID:18191430 PMID:29027214
NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798
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BCAR3
BCAR3 adaptor protein, NSP family member
decreases expression
ISO
Diclofenac results in decreased expression of BCAR3 mRNA
CTD
PMID:35537566
NCBI chr 1:93,561,741...93,848,151
Ensembl chr 1:93,561,741...93,847,150
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BCL2
BCL2 apoptosis regulator
increases expression
EXP ISO
Diclofenac results in increased expression of BCL2 mRNA
CTD
PMID:29027214
NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
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BCL2A1
BCL2 related protein A1
decreases expression
EXP
Diclofenac results in decreased expression of BCL2A1 mRNA
CTD
PMID:19192274
NCBI chr15:79,960,892...79,971,196
Ensembl chr15:79,960,892...79,971,196
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BCL2L1
BCL2 like 1
increases expression affects expression
EXP
Diclofenac results in increased expression of BCL2L1 mRNA alternative form Diclofenac affects the expression of BCL2L1 mRNA
CTD
PMID:14609740 PMID:24752500
NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989
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BCL2L11
BCL2 like 11
affects expression
EXP
Diclofenac affects the expression of BCL2L11 mRNA
CTD
PMID:24752500
NCBI chr 2:111,120,914...111,168,445
Ensembl chr 2:111,119,378...111,168,444
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BCL3
BCL3 transcription coactivator
increases expression
ISO
Diclofenac results in increased expression of BCL3 mRNA
CTD
PMID:26934552
NCBI chr19:44,747,705...44,760,044
Ensembl chr19:44,747,705...44,760,044
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BCL6
BCL6 transcription repressor
decreases expression
ISO
Diclofenac results in decreased expression of BCL6 mRNA
CTD
PMID:26934552
NCBI chr 3:187,721,377...187,745,468
Ensembl chr 3:187,721,377...187,745,725
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BDH1
3-hydroxybutyrate dehydrogenase 1
decreases expression
ISO
Diclofenac results in decreased expression of BDH1 mRNA
CTD
PMID:26934552
NCBI chr 3:197,509,783...197,573,343
Ensembl chr 3:197,509,783...197,573,323
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BID
BH3 interacting domain death agonist
multiple interactions affects expression increases activity
EXP
1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Diclofenac results in increased activity of BID protein] Diclofenac affects the expression of BID mRNA
CTD
PMID:18191430 PMID:24752500
NCBI chr22:17,734,138...17,774,665
Ensembl chr22:17,734,138...17,774,770
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BMP4
bone morphogenetic protein 4
affects expression
EXP
Diclofenac affects the expression of BMP4 mRNA
CTD
PMID:24752500
NCBI chr14:53,949,736...53,956,891
Ensembl chr14:53,949,736...53,958,761
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BMP6
bone morphogenetic protein 6
decreases expression increases expression
ISO EXP
Diclofenac results in decreased expression of BMP6 mRNA Diclofenac results in increased expression of BMP6 mRNA
CTD
PMID:26934552 PMID:32816093
NCBI chr 6:7,726,099...7,881,728
Ensembl chr 6:7,726,099...7,881,728
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BRAF
B-Raf proto-oncogene, serine/threonine kinase
affects expression
EXP
Diclofenac affects the expression of BRAF mRNA
CTD
PMID:24752500
NCBI chr 7:140,713,328...140,924,929
Ensembl chr 7:140,719,327...140,924,929
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BRCA1
BRCA1 DNA repair associated
increases expression
ISO
Diclofenac results in increased expression of BRCA1 mRNA
CTD
PMID:26934552
NCBI chr17:43,044,295...43,170,327
Ensembl chr17:43,044,295...43,170,245
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BRD3OS
BRD3 opposite strand
decreases expression
ISO
Diclofenac results in decreased expression of BRD3OS mRNA
CTD
PMID:35537566
NCBI chr 9:134,025,481...134,031,587
Ensembl chr 9:134,025,481...134,034,666
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BRDT
bromodomain testis associated
decreases expression
ISO
Diclofenac results in decreased expression of BRDT mRNA
CTD
PMID:35537566
NCBI chr 1:91,949,371...92,014,428
Ensembl chr 1:91,949,343...92,014,426
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BRIP1
BRCA1 interacting helicase 1
affects expression
EXP
Diclofenac affects the expression of BRIP1 mRNA
CTD
PMID:24752500
NCBI chr17:61,679,139...61,863,528
Ensembl chr17:61,679,139...61,863,559
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BTG1
BTG anti-proliferation factor 1
decreases expression
ISO
Diclofenac results in decreased expression of BTG1 mRNA
CTD
PMID:26934552
NCBI chr12:92,140,278...92,145,846
Ensembl chr12:92,140,278...92,145,846
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C1QA
complement C1q A chain
increases expression
ISO
Diclofenac results in increased expression of C1QA mRNA
CTD
PMID:26934552
NCBI chr 1:22,636,463...22,639,678
Ensembl chr 1:22,635,077...22,639,678
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C1QB
complement C1q B chain
increases expression
ISO
Diclofenac results in increased expression of C1QB mRNA
CTD
PMID:26934552
NCBI chr 1:22,653,236...22,661,637
Ensembl chr 1:22,652,762...22,661,637
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C1QC
complement C1q C chain
increases expression
ISO
Diclofenac results in increased expression of C1QC mRNA
CTD
PMID:26934552
NCBI chr 1:22,643,633...22,648,108
Ensembl chr 1:22,643,014...22,648,110
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C2
complement C2
increases expression
ISO
Diclofenac results in increased expression of C2 mRNA
CTD
PMID:26934552
NCBI chr 6:31,897,783...31,945,672
Ensembl chr 6:31,897,785...31,945,673
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C4B
complement C4B (Chido/Rodgers blood group)
increases expression
ISO
Diclofenac results in increased expression of C4B mRNA
CTD
PMID:26934552
NCBI chr 6:32,014,795...32,035,418
Ensembl chr 6:32,014,795...32,035,418
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CA1
carbonic anhydrase 1
decreases expression
ISO
Diclofenac results in decreased expression of CAR1 mRNA
CTD
PMID:26934552
NCBI chr 8:85,327,608...85,378,113
Ensembl chr 8:85,327,608...85,379,014
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CA13
carbonic anhydrase 13
decreases expression
ISO
Diclofenac results in decreased expression of CAR13 mRNA
CTD
PMID:26934552
NCBI chr 8:85,245,458...85,284,073
Ensembl chr 8:85,220,587...85,284,073
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CA3
carbonic anhydrase 3
decreases expression increases secretion
ISO
Diclofenac results in decreased expression of CAR3 mRNA Diclofenac results in increased secretion of CAR3 protein
CTD
PMID:24038040 PMID:26934552
NCBI chr 8:85,438,859...85,449,040
Ensembl chr 8:85,373,436...85,449,040
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CACNA1B
calcium voltage-gated channel subunit alpha1 B
decreases expression
ISO
Diclofenac results in decreased expression of CACNA1B mRNA
CTD
PMID:26934552
NCBI chr 9:137,877,782...138,124,619
Ensembl chr 9:137,877,782...138,124,624
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CALCA
calcitonin related polypeptide alpha
decreases expression
ISO
Diclofenac results in decreased expression of CALCA mRNA
CTD
PMID:11588175
NCBI chr11:14,966,668...14,972,351
Ensembl chr11:14,966,622...14,972,354
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CALM1
calmodulin 1
affects expression
EXP
Diclofenac affects the expression of CALM1 mRNA
CTD
PMID:24752500
NCBI chr14:90,396,502...90,408,268
Ensembl chr14:90,396,502...90,408,268
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CALML3
calmodulin like 3
increases expression
ISO
Diclofenac results in increased expression of CALML3 mRNA
CTD
PMID:30723492
NCBI chr10:5,524,961...5,526,771
Ensembl chr10:5,524,961...5,526,771
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CALR
calreticulin
affects expression decreases expression
ISO
Diclofenac affects the expression of CALR mRNA Diclofenac results in decreased expression of CALR mRNA
CTD
PMID:18246545
NCBI chr19:12,938,609...12,944,489
Ensembl chr19:12,938,578...12,944,489
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CAMK1D
calcium/calmodulin dependent protein kinase ID
increases expression
ISO
Diclofenac results in increased expression of CAMK1D mRNA
CTD
PMID:26934552
NCBI chr10:12,349,547...12,835,545
Ensembl chr10:12,349,547...12,835,545
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CAMK2B
calcium/calmodulin dependent protein kinase II beta
increases expression
ISO
Diclofenac results in increased expression of CAMK2B mRNA
CTD
PMID:30723492
NCBI chr 7:44,217,154...44,326,013
Ensembl chr 7:44,210,019...44,334,577
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CAMP
cathelicidin antimicrobial peptide
increases expression
ISO
Diclofenac results in increased expression of CAMP mRNA
CTD
PMID:26934552
NCBI chr 3:48,223,495...48,225,485
Ensembl chr 3:48,223,347...48,225,491
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CAPN10
calpain 10
affects expression
EXP
Diclofenac affects the expression of CAPN10 mRNA
CTD
PMID:24752500
NCBI chr 2:240,586,734...240,599,104
Ensembl chr 2:240,586,734...240,617,705
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CARS1
cysteinyl-tRNA synthetase 1
decreases expression
ISO
Diclofenac results in decreased expression of CARS1 mRNA
CTD
PMID:35537566
NCBI chr11:3,000,929...3,057,423
Ensembl chr11:3,000,922...3,057,613
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CASP1
caspase 1
multiple interactions
ISO
Diclofenac inhibits the reaction [Freund's Adjuvant results in increased cleavage of CASP1 protein]
CTD
PMID:25450234
NCBI chr11:105,025,443...105,036,686
Ensembl chr11:105,025,397...105,035,250
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CASP10
caspase 10
multiple interactions affects expression
EXP
[Diclofenac co-treated with Hyaluronic Acid] results in increased activity of CASP10 protein Diclofenac affects the expression of CASP10 mRNA
CTD
PMID:20237495 PMID:24752500
NCBI chr 2:201,183,141...201,229,406
Ensembl chr 2:201,182,872...201,229,428
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CASP2
caspase 2
multiple interactions affects expression
EXP
Diclofenac inhibits the reaction [Thapsigargin results in increased activity of CASP2 protein]; Diclofenac inhibits the reaction [Tunicamycin results in increased activity of CASP2 protein] Diclofenac affects the expression of CASP2 mRNA
CTD
PMID:16388830 PMID:24752500
NCBI chr 7:143,288,351...143,307,696
Ensembl chr 7:143,288,215...143,307,696
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CASP3
caspase 3
increases activity multiple interactions
ISO EXP
Diclofenac results in increased activity of CASP3 protein 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Diclofenac results in increased activity of CASP3 protein]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [IFNG protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [TNF protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 2-aminoethoxydiphenyl borate inhibits the reaction [[TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 2-aminoethoxydiphenyl borate inhibits the reaction [TNF protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; [TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac results in increased activity of CASP3 protein]; Diclofenac inhibits the reaction [Thapsigargin results in increased activity of CASP3 protein]; Diclofenac inhibits the reaction [Tunicamycin results in increased activity of CASP3 protein]; IFNG protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]; TNF protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein] 2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone inhibits the reaction [Diclofenac results in increased activity of CASP3 protein]; [Water deficiency co-treated with Diclofenac] results in increased expression of CASP3 protein; alpha-Tocopherol inhibits the reaction [Diclofenac results in increased activity of CASP3 protein]; Cyclosporine inhibits the reaction [Diclofenac results in increased activity of CASP3 protein]; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in increased expression of CASP3 protein]; Thiourea analog inhibits the reaction [Diclofenac results in increased activity of CASP3 protein]
CTD
PMID:12826271 PMID:14599462 PMID:14609740 PMID:16388830 PMID:24770551 PMID:26609140 PMID:27313093 PMID:31042592 More...
NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
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CASP6
caspase 6
affects expression
EXP
Diclofenac affects the expression of CASP6 mRNA
CTD
PMID:24752500
NCBI chr 4:109,664,388...109,709,767
Ensembl chr 4:109,688,622...109,703,583
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CASP8
caspase 8
increases activity multiple interactions affects expression
ISO EXP
Diclofenac results in increased activity of CASP8 protein [Diclofenac co-treated with Hyaluronic Acid] results in increased activity of CASP8 protein; [TNF protein co-treated with Diclofenac] results in increased activity of CASP8 protein; Acetylcysteine inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [Diclofenac results in increased activity of CASP8 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP8 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [Diclofenac results in increased activity of CASP8 protein] Diclofenac affects the expression of CASP8 mRNA
CTD
PMID:14609740 PMID:20237495 PMID:24752500 PMID:27313093
NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836
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CASP9
caspase 9
multiple interactions increases activity increases expression
EXP ISO
[TNF protein co-treated with Diclofenac] results in increased activity of CASP9 protein; Acetylcysteine inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [Diclofenac results in increased activity of CASP9 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP9 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [Diclofenac results in increased activity of CASP9 protein]; Diclofenac inhibits the reaction [Thapsigargin results in increased activity of CASP9 protein]; Diclofenac inhibits the reaction [Tunicamycin results in increased activity of CASP9 protein] Diclofenac results in increased expression of CASP9 mRNA
CTD
PMID:14609740 PMID:16388830 PMID:25014874 PMID:27313093 PMID:29027214
NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
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CAT
catalase
increases activity decreases activity multiple interactions
ISO
Diclofenac results in increased activity of CAT protein Diclofenac results in decreased activity of CAT protein Ondansetron promotes the reaction [Diclofenac results in decreased activity of CAT protein] [Water deficiency co-treated with Diclofenac] results in decreased activity of CAT protein; Acetylcysteine inhibits the reaction [Diclofenac results in decreased activity of CAT protein]; Diclofenac inhibits the reaction [Freund's Adjuvant results in decreased activity of CAT protein]; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in decreased activity of CAT protein]; Silymarin inhibits the reaction [Diclofenac results in decreased activity of CAT protein]
CTD
PMID:17274466 PMID:23994749 PMID:28535741 PMID:31042592 PMID:31332906
NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
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CBL
Cbl proto-oncogene
affects expression
EXP
Diclofenac affects the expression of CBL mRNA
CTD
PMID:24752500
NCBI chr11:119,206,339...119,308,149
Ensembl chr11:119,206,298...119,313,926
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CBR1
carbonyl reductase 1
affects expression
EXP
Diclofenac affects the expression of CBR1 mRNA
CTD
PMID:24752500
NCBI chr21:36,070,024...36,073,164
Ensembl chr21:36,069,941...36,073,166
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CBS
cystathionine beta-synthase
affects expression
EXP
Diclofenac affects the expression of CBS mRNA
CTD
PMID:24752500
NCBI chr21:43,053,191...43,076,873
Ensembl chr21:43,053,191...43,076,943
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CCDC137
coiled-coil domain containing 137
increases expression
ISO
Diclofenac results in increased expression of CCDC137 mRNA
CTD
PMID:35537566
NCBI chr17:81,666,737...81,673,899
Ensembl chr17:81,666,737...81,673,904
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CCL15
C-C motif chemokine ligand 15
increases expression
ISO
Diclofenac results in increased expression of CCL6 mRNA
CTD
PMID:26934552
NCBI chr17:35,997,582...36,001,553
Ensembl chr17:35,996,440...36,001,553
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CCL2
C-C motif chemokine ligand 2
multiple interactions increases secretion increases expression affects expression
ISO EXP
[Water deficiency co-treated with Diclofenac] results in increased expression of CCL2 protein; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 mRNA]; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in increased expression of CCL2 protein] Diclofenac analog results in increased secretion of CCL2 protein SB 203580 inhibits the reaction [Diclofenac analog results in increased expression of CCL2 mRNA]; U 0126 inhibits the reaction [Diclofenac analog results in increased expression of CCL2 mRNA] Diclofenac results in increased expression of CCL2 protein Diclofenac affects the expression of CCL2 mRNA Diclofenac results in increased expression of CCL2 mRNA
CTD
PMID:22285467 PMID:23939143 PMID:24104198 PMID:25051504 PMID:27671914 PMID:31042592 More...
NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208
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CCL23
C-C motif chemokine ligand 23
increases expression
ISO
Diclofenac results in increased expression of CCL9 mRNA
CTD
PMID:26934552
NCBI chr17:36,013,058...36,017,972
Ensembl chr17:36,013,056...36,017,972
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CCL3
C-C motif chemokine ligand 3
multiple interactions decreases expression
ISO
Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL3 mRNA] Diclofenac results in decreased expression of CCL3 mRNA
CTD
PMID:23939143 PMID:35537566
NCBI chr17:36,088,256...36,090,143
Ensembl chr17:36,088,256...36,090,169
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CCN1
cellular communication network factor 1
affects expression increases expression
EXP
Diclofenac affects the expression of CCN1 mRNA Diclofenac results in increased expression of CCN1 mRNA
CTD
PMID:19192274 PMID:24752500
NCBI chr 1:85,580,761...85,583,950
Ensembl chr 1:85,580,761...85,584,589
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CCND1
cyclin D1
multiple interactions decreases expression increases expression affects expression
EXP ISO
Diclofenac inhibits the reaction [TNF protein results in increased expression of CCND1 protein] Diclofenac results in decreased expression of CCND1 protein Diclofenac results in increased expression of CCND1 mRNA Diclofenac results in decreased expression of CCND1 mRNA Diclofenac affects the expression of CCND1 mRNA
CTD
PMID:15188006 PMID:15489888 PMID:19022234 PMID:26934552
NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
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CCND3
cyclin D3
affects expression
EXP
Diclofenac affects the expression of CCND3 mRNA
CTD
PMID:24752500
NCBI chr 6:41,934,933...42,050,035
Ensembl chr 6:41,934,934...42,050,357
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CCNE1
cyclin E1
affects expression
EXP
Diclofenac affects the expression of CCNE1 mRNA
CTD
PMID:24752500
NCBI chr19:29,811,991...29,824,312
Ensembl chr19:29,811,991...29,824,312
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CCNE2
cyclin E2
affects expression
EXP
Diclofenac affects the expression of CCNE2 mRNA
CTD
PMID:24752500
NCBI chr 8:94,880,224...94,896,693
Ensembl chr 8:94,879,770...94,896,678
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CCNF
cyclin F
affects expression
EXP
Diclofenac affects the expression of CCNF mRNA
CTD
PMID:24752500
NCBI chr16:2,429,447...2,458,854
Ensembl chr16:2,429,394...2,458,854
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CCNG1
cyclin G1
increases expression
ISO
Diclofenac results in increased expression of CCNG1 mRNA
CTD
PMID:19022234
NCBI chr 5:163,437,571...163,457,640
Ensembl chr 5:163,437,569...163,446,151
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CCNH
cyclin H
affects expression
EXP
Diclofenac affects the expression of CCNH mRNA
CTD
PMID:24752500
NCBI chr 5:87,311,471...87,412,930
Ensembl chr 5:87,318,416...87,413,029
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CCR1
C-C motif chemokine receptor 1
increases expression
ISO
Diclofenac results in increased expression of CCR1 mRNA
CTD
PMID:26934552
NCBI chr 3:46,201,711...46,208,313
Ensembl chr 3:46,201,711...46,208,313
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CCR5
C-C motif chemokine receptor 5
increases expression
ISO
Diclofenac results in increased expression of CCR5 mRNA
CTD
PMID:26934552
NCBI chr 3:46,370,142...46,376,206
Ensembl chr 3:46,370,946...46,376,206
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CD14
CD14 molecule
increases expression
ISO
Diclofenac results in increased expression of CD14 mRNA
CTD
PMID:26934552
NCBI chr 5:140,631,732...140,633,701
Ensembl chr 5:140,631,728...140,633,700
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CD163
CD163 molecule
increases expression
ISO
Diclofenac results in increased expression of CD163 mRNA
CTD
PMID:26934552
NCBI chr12:7,470,811...7,503,777
Ensembl chr12:7,470,811...7,503,893
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CD200R1L
CD200 receptor 1 like
decreases expression
ISO
Diclofenac results in decreased expression of CD200R4 mRNA
CTD
PMID:35537566
NCBI chr 3:112,815,711...112,846,864
Ensembl chr 3:112,815,709...112,846,864
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CD244
CD244 molecule
decreases expression
ISO
Diclofenac results in decreased expression of CD244 mRNA
CTD
PMID:35537566
NCBI chr 1:160,830,160...160,862,887
Ensembl chr 1:160,830,160...160,862,887
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CD28
CD28 molecule
increases expression
ISO
Diclofenac results in increased expression of CD28 mRNA
CTD
PMID:26934552
NCBI chr 2:203,706,482...203,738,912
Ensembl chr 2:203,706,475...203,738,912
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CD44
CD44 molecule (IN blood group)
increases expression
ISO
Diclofenac results in increased expression of CD44 mRNA
CTD
PMID:26934552
NCBI chr11:35,139,171...35,232,402
Ensembl chr11:35,138,882...35,232,402
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CD55
CD55 molecule (Cromer blood group)
increases expression
ISO
Diclofenac results in increased expression of CD55 mRNA
CTD
PMID:26934552
NCBI chr 1:207,321,678...207,360,966
Ensembl chr 1:207,321,519...207,386,804
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CD5L
CD5 molecule like
increases expression
ISO
Diclofenac results in increased expression of CD5L mRNA
CTD
PMID:26934552
NCBI chr 1:157,827,068...157,841,808
Ensembl chr 1:157,830,911...157,898,256
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CD9
CD9 molecule
increases expression
ISO
Diclofenac results in increased expression of CD9 mRNA
CTD
PMID:26934552
NCBI chr12:6,199,946...6,238,266
Ensembl chr12:6,199,715...6,238,271
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CDC42EP5
CDC42 effector protein 5
decreases expression
ISO
Diclofenac results in decreased expression of CDC42EP5 mRNA
CTD
PMID:26934552
NCBI chr19:54,465,026...54,473,296
Ensembl chr19:54,465,026...54,473,296
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CDC6
cell division cycle 6
affects expression
EXP
Diclofenac affects the expression of CDC6 mRNA
CTD
PMID:24752500
NCBI chr17:40,287,879...40,304,657
Ensembl chr17:40,287,879...40,304,657
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CDC7
cell division cycle 7
affects expression
EXP
Diclofenac affects the expression of CDC7 mRNA
CTD
PMID:24752500
NCBI chr 1:91,500,851...91,525,764
Ensembl chr 1:91,500,851...91,525,764
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CDCA5
cell division cycle associated 5
increases expression
ISO
Diclofenac results in increased expression of CDCA5 mRNA
CTD
PMID:26934552
NCBI chr11:65,061,093...65,084,040
Ensembl chr11:65,066,300...65,084,164
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CDH1
cadherin 1
increases expression affects expression decreases expression
EXP ISO
Diclofenac results in increased expression of CDH1 protein Diclofenac affects the expression of CDH1 mRNA Diclofenac results in decreased expression of CDH1 mRNA
CTD
PMID:19022234 PMID:19628293 PMID:24752500
NCBI chr16:68,737,292...68,835,537
Ensembl chr16:68,737,292...68,835,537
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CDK2
cyclin dependent kinase 2
affects expression
EXP
Diclofenac affects the expression of CDK2 mRNA
CTD
PMID:24752500
NCBI chr12:55,966,830...55,972,789
Ensembl chr12:55,966,781...55,972,789
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CDK5
cyclin dependent kinase 5
affects expression
EXP
Diclofenac affects the expression of CDK5 mRNA
CTD
PMID:24752500
NCBI chr 7:151,053,815...151,057,897
Ensembl chr 7:151,053,815...151,057,897
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CDK5R1
cyclin dependent kinase 5 regulatory subunit 1
increases expression
ISO
Diclofenac results in increased expression of CDK5R1 mRNA
CTD
PMID:30723492
NCBI chr17:32,486,993...32,491,253
Ensembl chr17:32,486,993...32,491,253
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CDK6
cyclin dependent kinase 6
affects expression
EXP
Diclofenac affects the expression of CDK6 mRNA
CTD
PMID:24752500
NCBI chr 7:92,604,921...92,836,573
Ensembl chr 7:92,604,921...92,836,573
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CDK7
cyclin dependent kinase 7
affects expression
EXP
Diclofenac affects the expression of CDK7 mRNA
CTD
PMID:24752500
NCBI chr 5:69,234,795...69,277,430
Ensembl chr 5:69,234,795...69,277,430
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CDKN1A
cyclin dependent kinase inhibitor 1A
increases expression
EXP ISO
Diclofenac results in increased expression of CDKN1A mRNA
CTD
PMID:19022234 PMID:26934552
NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337
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CDKN1B
cyclin dependent kinase inhibitor 1B
affects expression
EXP
Diclofenac affects the expression of CDKN1B mRNA
CTD
PMID:24752500
NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,685,498...12,722,369
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CDT1
chromatin licensing and DNA replication factor 1
affects expression
EXP
Diclofenac affects the expression of CDT1 mRNA
CTD
PMID:24752500
NCBI chr16:88,803,789...88,809,258
Ensembl chr16:88,803,789...88,809,258
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CEBPB
CCAAT enhancer binding protein beta
increases expression affects expression
EXP ISO
Diclofenac results in increased expression of CEBPB mRNA Diclofenac affects the expression of CEBPB mRNA
CTD
PMID:19022234 PMID:24752500
NCBI chr20:50,190,583...50,192,690
Ensembl chr20:50,190,830...50,192,668
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CEBPG
CCAAT enhancer binding protein gamma
decreases expression
ISO
Diclofenac results in decreased expression of CEBPG mRNA
CTD
PMID:35537566
NCBI chr19:33,373,709...33,382,686
Ensembl chr19:33,373,685...33,382,686
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CEP162
centrosomal protein 162
decreases expression
ISO
Diclofenac results in decreased expression of CEP162 mRNA
CTD
PMID:35537566
NCBI chr 6:84,124,250...84,227,643
Ensembl chr 6:84,124,241...84,227,643
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CERS6
ceramide synthase 6
increases expression
ISO
Diclofenac results in increased expression of CERS6 mRNA
CTD
PMID:26934552
NCBI chr 2:168,456,272...168,775,134
Ensembl chr 2:168,456,249...168,775,134
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CES1
carboxylesterase 1
decreases expression
ISO
Diclofenac results in decreased expression of CES1D mRNA
CTD
PMID:26934552
NCBI chr16:55,802,851...55,833,096
Ensembl chr16:55,802,851...55,833,337
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CFH
complement factor H
increases expression
ISO
Diclofenac results in increased expression of CFH mRNA
CTD
PMID:26934552
NCBI chr 1:196,652,043...196,747,504
Ensembl chr 1:196,651,754...196,752,476
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CFLAR
CASP8 and FADD like apoptosis regulator
multiple interactions affects expression
EXP
[Diclofenac co-treated with Hyaluronic Acid] results in decreased expression of CFLAR protein Diclofenac affects the expression of CFLAR mRNA
CTD
PMID:20237495 PMID:24752500
NCBI chr 2:201,116,164...201,176,687
Ensembl chr 2:201,116,154...201,176,687
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CGREF1
cell growth regulator with EF-hand domain 1
decreases expression
ISO
Diclofenac results in decreased expression of CGREF1 mRNA
CTD
PMID:26934552
NCBI chr 2:27,099,353...27,119,128
Ensembl chr 2:27,098,889...27,119,128
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CHAC1
ChaC glutathione specific gamma-glutamylcyclotransferase 1
increases expression decreases expression
ISO
Diclofenac results in increased expression of CHAC1 mRNA Diclofenac results in decreased expression of CHAC1 mRNA
CTD
PMID:26934552 PMID:35537566
NCBI chr15:40,953,471...40,956,512
Ensembl chr15:40,952,962...40,956,512
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CHDH
choline dehydrogenase
affects expression
EXP
Diclofenac affects the expression of CHDH mRNA
CTD
PMID:24752500
NCBI chr 3:53,812,335...53,846,419
Ensembl chr 3:53,812,335...53,846,419
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CHEK1
checkpoint kinase 1
affects expression
EXP
Diclofenac affects the expression of CHEK1 mRNA
CTD
PMID:24752500
NCBI chr11:125,625,136...125,681,124
Ensembl chr11:125,625,163...125,676,255
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CHKA
choline kinase alpha
affects expression
EXP
Diclofenac affects the expression of CHKA mRNA
CTD
PMID:24752500
NCBI chr11:68,052,859...68,121,388
Ensembl chr11:68,052,859...68,121,444
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CHKB
choline kinase beta
affects expression
EXP
Diclofenac affects the expression of CHKB mRNA
CTD
PMID:24752500
NCBI chr22:50,578,963...50,582,849
Ensembl chr22:50,578,959...50,601,455
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CHL1
cell adhesion molecule L1 like
increases expression
ISO
Diclofenac results in increased expression of CHL1 mRNA
CTD
PMID:26934552
NCBI chr 3:196,763...409,417
Ensembl chr 3:196,763...409,417
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CHST4
carbohydrate sulfotransferase 4
decreases expression
ISO
Diclofenac results in decreased expression of CHST4 mRNA
CTD
PMID:26934552
NCBI chr16:71,526,120...71,538,748
Ensembl chr16:71,525,233...71,538,748
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CHUK
component of inhibitor of nuclear factor kappa B kinase complex
multiple interactions
EXP ISO
Diclofenac inhibits the reaction [TNF protein results in increased activity of CHUK protein] Diclofenac inhibits the reaction [Freund's Adjuvant results in increased phosphorylation of CHUK protein]
CTD
PMID:15489888 PMID:25935278
NCBI chr10:100,186,319...100,229,596
Ensembl chr10:100,188,300...100,229,596
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CLEC2D
C-type lectin domain family 2 member D
decreases expression
ISO
Diclofenac results in decreased expression of CLEC2H mRNA
CTD
PMID:26934552
NCBI chr12:9,669,713...9,699,553
Ensembl chr12:9,664,969...9,699,553
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CLEC6A
C-type lectin domain containing 6A
increases expression
ISO
Diclofenac results in increased expression of CLEC4N mRNA
CTD
PMID:26934552
NCBI chr12:8,455,962...8,478,330
Ensembl chr12:8,455,962...8,478,330
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CLU
clusterin
increases expression multiple interactions
ISO
Diclofenac results in increased expression of CLU protein [Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of CLU protein
CTD
PMID:23506792 PMID:25772430
NCBI chr 8:27,596,917...27,614,700
Ensembl chr 8:27,596,917...27,614,700
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CMPK2
cytidine/uridine monophosphate kinase 2
affects expression
EXP
Diclofenac affects the expression of CMPK2 mRNA
CTD
PMID:24752500
NCBI chr 2:6,840,553...6,866,635
Ensembl chr 2:6,840,570...6,866,635
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COL3A1
collagen type III alpha 1 chain
decreases expression multiple interactions
ISO
Diclofenac results in decreased expression of COL3A1 mRNA [Water deficiency co-treated with Diclofenac] results in increased expression of COL3A1 protein; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in increased expression of COL3A1 protein]
CTD
PMID:26934552 PMID:31042592
NCBI chr 2:188,974,373...189,012,746
Ensembl chr 2:188,974,373...189,012,746
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COTL1
coactosin like F-actin binding protein 1
increases expression
ISO
Diclofenac results in increased expression of COTL1 mRNA
CTD
PMID:26934552
NCBI chr16:84,565,596...84,618,078
Ensembl chr16:84,565,596...84,618,078
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COX4I2
cytochrome c oxidase subunit 4I2
increases expression
ISO
Diclofenac results in increased expression of COX4I2 mRNA
CTD
PMID:35537566
NCBI chr20:31,637,912...31,645,006
Ensembl chr20:31,637,912...31,645,006
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COX6A2
cytochrome c oxidase subunit 6A2
decreases expression
ISO
Diclofenac results in decreased expression of COX6A2 mRNA
CTD
PMID:35537566
NCBI chr16:31,427,731...31,428,360
Ensembl chr16:31,427,731...31,428,360
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CPB2
carboxypeptidase B2
increases expression
ISO
Diclofenac results in increased expression of CPB2 mRNA
CTD
PMID:26934552
NCBI chr13:46,053,186...46,105,033
Ensembl chr13:46,053,186...46,105,033
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CPLX1
complexin 1
increases expression
ISO
Diclofenac results in increased expression of CPLX1 mRNA
CTD
PMID:30723492
NCBI chr 4:784,957...826,129
Ensembl chr 4:784,957...826,129
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CPLX4
complexin 4
increases expression
ISO
Diclofenac results in increased expression of CPLX4 mRNA
CTD
PMID:30723492
NCBI chr18:59,295,402...59,318,649
Ensembl chr18:59,275,156...59,318,649
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CPNE8
copine 8
increases expression
ISO
Diclofenac results in increased expression of CPNE8 mRNA
CTD
PMID:26934552
NCBI chr12:38,652,203...38,906,835
Ensembl chr12:38,646,822...38,907,430
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CPSF6
cleavage and polyadenylation specific factor 6
affects expression
EXP
Diclofenac affects the expression of CPSF6 mRNA
CTD
PMID:24752500
NCBI chr12:69,239,569...69,274,358
Ensembl chr12:69,239,569...69,274,358
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CPT1A
carnitine palmitoyltransferase 1A
increases expression
EXP ISO
Diclofenac results in increased expression of CPT1A mRNA
CTD
PMID:19022234
NCBI chr11:68,754,620...68,844,277
Ensembl chr11:68,754,620...68,844,410
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CR1L
complement C3b/C4b receptor 1 like
multiple interactions
ISO
[Water deficiency co-treated with Diclofenac] results in decreased expression of CR1L protein; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in decreased expression of CR1L protein]
CTD
PMID:31042592
NCBI chr 1:207,645,133...207,723,703
Ensembl chr 1:207,645,113...207,738,416
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CR2
complement C3d receptor 2
affects expression
ISO
Diclofenac affects the expression of CR2 mRNA
CTD
PMID:26934552
NCBI chr 1:207,454,328...207,489,892
Ensembl chr 1:207,453,024...207,489,895
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CREB3L2
cAMP responsive element binding protein 3 like 2
increases expression
ISO
Diclofenac results in increased expression of CREB3L2 mRNA
CTD
PMID:26934552
NCBI chr 7:137,874,979...138,002,086
Ensembl chr 7:137,874,979...138,002,086
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CREB3L4
cAMP responsive element binding protein 3 like 4
affects expression
EXP
Diclofenac affects the expression of CREB3L4 mRNA
CTD
PMID:24752500
NCBI chr 1:153,967,487...153,974,359
Ensembl chr 1:153,967,534...153,974,361
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CRP
C-reactive protein
multiple interactions decreases expression
ISO EXP
[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of CRP protein; Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CRP protein]; lipopolysaccharide, E coli O55-B5 inhibits the reaction [Diclofenac results in decreased expression of CRP protein] Diclofenac inhibits the reaction [TNF protein results in increased expression of CRP mRNA]; Diclofenac inhibits the reaction [TNF protein results in increased secretion of CRP protein]
CTD
PMID:25772430 PMID:27313093
NCBI chr 1:159,712,289...159,714,589
Ensembl chr 1:159,712,289...159,714,589
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CRY1
cryptochrome circadian regulator 1
decreases expression
ISO
Diclofenac results in decreased expression of CRY1 mRNA
CTD
PMID:26934552
NCBI chr12:106,991,364...107,093,549
Ensembl chr12:106,991,364...107,093,549
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CSF1
colony stimulating factor 1
decreases expression
ISO
Diclofenac results in decreased expression of CSF1 mRNA
CTD
PMID:26934552 PMID:35537566
NCBI chr 1:109,910,506...109,930,992
Ensembl chr 1:109,910,242...109,930,992
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CSF1R
colony stimulating factor 1 receptor
increases secretion increases expression
ISO
Diclofenac results in increased secretion of CSF1R protein Diclofenac results in increased expression of CSF1R mRNA
CTD
PMID:26934552
NCBI chr 5:150,053,295...150,113,365
Ensembl chr 5:150,053,291...150,113,372
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CSF2RB
colony stimulating factor 2 receptor subunit beta
increases expression
ISO
Diclofenac results in increased expression of CSF2RB mRNA; Diclofenac results in increased expression of CSF2RB2 mRNA
CTD
PMID:26934552
NCBI chr22:36,913,628...36,940,439
Ensembl chr22:36,913,628...36,940,439
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CSNK2A1
casein kinase 2 alpha 1
affects expression
EXP
Diclofenac affects the expression of CSNK2A1 mRNA
CTD
PMID:24752500
NCBI chr20:472,498...543,790
Ensembl chr20:472,498...543,835
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CSNK2A2
casein kinase 2 alpha 2
affects expression
EXP
Diclofenac affects the expression of CSNK2A2 mRNA
CTD
PMID:24752500
NCBI chr16:58,157,907...58,198,106
Ensembl chr16:58,157,907...58,198,106
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CSRNP3
cysteine and serine rich nuclear protein 3
increases expression
ISO
Diclofenac results in increased expression of CSRNP3 mRNA
CTD
PMID:30723492
NCBI chr 2:165,469,698...165,689,407
Ensembl chr 2:165,469,647...165,689,407
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CSTF2
cleavage stimulation factor subunit 2
affects expression
EXP
Diclofenac affects the expression of CSTF2 mRNA
CTD
PMID:24752500
NCBI chr X:100,820,391...100,841,520
Ensembl chr X:100,820,391...100,841,520
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CSTF3
cleavage stimulation factor subunit 3
affects expression
EXP
Diclofenac affects the expression of CSTF3 mRNA
CTD
PMID:24752500
NCBI chr11:33,084,584...33,161,480
Ensembl chr11:33,077,188...33,162,371
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CTBP2
C-terminal binding protein 2
affects expression
EXP
Diclofenac affects the expression of CTBP2 mRNA
CTD
PMID:24752500
NCBI chr10:124,984,317...125,162,463
Ensembl chr10:124,984,317...125,161,170
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CTH
cystathionine gamma-lyase
affects expression decreases expression
EXP ISO
Diclofenac affects the expression of CTH mRNA Diclofenac results in decreased expression of CTH mRNA
CTD
PMID:24752500 PMID:35537566
NCBI chr 1:70,411,268...70,439,851
Ensembl chr 1:70,411,218...70,439,851
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CTLA4
cytotoxic T-lymphocyte associated protein 4
increases expression
ISO
Diclofenac results in increased expression of CTLA4 protein
CTD
PMID:26934552
NCBI chr 2:203,867,771...203,873,965
Ensembl chr 2:203,853,888...203,873,965
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CTNNB1
catenin beta 1
affects expression
EXP
Diclofenac affects the expression of CTNNB1 mRNA
CTD
PMID:24752500
NCBI chr 3:41,199,505...41,240,443
Ensembl chr 3:41,194,741...41,260,096
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CTPS1
CTP synthase 1
affects expression
EXP
Diclofenac affects the expression of CTPS1 mRNA
CTD
PMID:24752500
NCBI chr 1:40,979,696...41,012,565
Ensembl chr 1:40,979,300...41,012,565
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CTPS2
CTP synthase 2
affects expression
EXP
Diclofenac affects the expression of CTPS2 mRNA
CTD
PMID:24752500
NCBI chr X:16,587,999...16,712,910
Ensembl chr X:16,587,999...16,712,936
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CTSC
cathepsin C
increases expression
ISO
Diclofenac results in increased expression of CTSC mRNA
CTD
PMID:26934552
NCBI chr11:88,293,592...88,337,736
Ensembl chr11:88,265,069...88,359,684
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CTSE
cathepsin E
decreases expression
ISO
Diclofenac results in decreased expression of CTSE mRNA
CTD
PMID:35537566
NCBI chr 1:206,009,264...206,023,895
Ensembl chr 1:206,008,535...206,023,909
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CTSS
cathepsin S
increases expression
ISO
Diclofenac results in increased expression of CTSS mRNA
CTD
PMID:26934552
NCBI chr 1:150,730,188...150,765,778
Ensembl chr 1:150,730,079...150,765,957
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CUL3
cullin 3
affects expression
EXP
Diclofenac affects the expression of CUL3 mRNA
CTD
PMID:24752500
NCBI chr 2:224,470,150...224,585,363
Ensembl chr 2:224,470,150...224,585,397
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CUL7
cullin 7
decreases expression
ISO
Diclofenac results in decreased expression of CUL7 mRNA
CTD
PMID:26934552
NCBI chr 6:43,037,617...43,053,851
Ensembl chr 6:43,037,617...43,053,943
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CXCL1
C-X-C motif chemokine ligand 1
multiple interactions decreases expression increases expression
ISO
Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CXCL1 mRNA]; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CXCL1 protein] Diclofenac results in decreased expression of CXCL1 mRNA Diclofenac results in increased expression of CXCL1 mRNA; Diclofenac results in increased expression of CXCL1 protein
CTD
PMID:23939143 PMID:26934552 PMID:27671914
NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308
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CXCL13
C-X-C motif chemokine ligand 13
increases expression
ISO
Diclofenac results in increased expression of CXCL13 mRNA
CTD
PMID:26934552
NCBI chr 4:77,511,753...77,611,834
Ensembl chr 4:77,511,753...77,611,834
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CXCL14
C-X-C motif chemokine ligand 14
increases expression
ISO
Diclofenac results in increased expression of CXCL14 mRNA
CTD
PMID:26934552
NCBI chr 5:135,570,679...135,578,991
Ensembl chr 5:135,570,679...135,579,279
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CXCL2
C-X-C motif chemokine ligand 2
multiple interactions increases expression
ISO
Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CXCL2 mRNA] Diclofenac results in increased expression of CXCL2 mRNA; Diclofenac results in increased expression of CXCL2 protein
CTD
PMID:22285467 PMID:23939143 PMID:24747151 PMID:26934552 PMID:27671914
NCBI chr 4:74,097,040...74,099,195
Ensembl chr 4:74,097,040...74,099,196
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CXCL8
C-X-C motif chemokine ligand 8
affects expression increases secretion increases expression multiple interactions decreases expression
EXP
Diclofenac affects the expression of CXCL8 mRNA Diclofenac analog results in increased secretion of CXCL8 protein Diclofenac analog results in increased expression of CXCL8 mRNA; Diclofenac results in increased expression of CXCL8 mRNA Diclofenac inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; Diclofenac inhibits the reaction [TNF protein results in increased secretion of CXCL8 protein]; Diclofenac promotes the reaction [Mustard Gas results in increased secretion of CXCL8 protein]; pyrazolanthrone inhibits the reaction [Diclofenac analog results in increased expression of CXCL8 mRNA]; SB 203580 inhibits the reaction [Diclofenac analog results in increased expression of CXCL8 mRNA] Diclofenac results in decreased expression of CXCL8 mRNA; Diclofenac results in decreased expression of CXCL8 protein
CTD
PMID:17379860 PMID:19192274 PMID:24104198 PMID:24752500 PMID:27313093 PMID:31048000 PMID:32816093 More...
NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716
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CXCR4
C-X-C motif chemokine receptor 4
decreases expression
EXP ISO
Diclofenac results in decreased expression of CXCR4 mRNA
CTD
PMID:19192274 PMID:35537566
NCBI chr 2:136,114,349...136,118,149
Ensembl chr 2:136,114,349...136,119,177
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CYB561
cytochrome b561
increases expression
ISO
Diclofenac results in increased expression of CYB561 mRNA
CTD
PMID:26934552
NCBI chr17:63,432,304...63,446,639
Ensembl chr17:63,432,304...63,446,354
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CYBA
cytochrome b-245 alpha chain
increases expression
ISO
Diclofenac results in increased expression of CYBA mRNA
CTD
PMID:26934552
NCBI chr16:88,643,289...88,651,053
Ensembl chr16:88,643,275...88,651,083
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CYBB
cytochrome b-245 beta chain
increases expression
ISO
Diclofenac results in increased expression of CYBB mRNA
CTD
PMID:26934552
NCBI chr X:37,780,059...37,813,461
Ensembl chr X:37,780,018...37,813,461
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CYCS
cytochrome c, somatic
affects expression
EXP
Diclofenac affects the expression of CYCS mRNA
CTD
PMID:24752500
NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
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CYP17A1
cytochrome P450 family 17 subfamily A member 1
increases expression
ISO
Diclofenac results in increased expression of CYP17A1 mRNA
CTD
PMID:26934552
NCBI chr10:102,830,531...102,837,413
Ensembl chr10:102,830,531...102,837,472
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CYP1A1
cytochrome P450 family 1 subfamily A member 1
increases expression decreases activity
EXP ISO
Diclofenac results in increased expression of CYP1A1 mRNA; Diclofenac results in increased expression of CYP1A1 protein Diclofenac results in decreased activity of CYP1A1 protein
CTD
PMID:18420780 PMID:21784029
NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
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CYP1A2
cytochrome P450 family 1 subfamily A member 2
increases expression decreases activity multiple interactions
EXP
Diclofenac results in increased expression of CYP1A2 mRNA; Diclofenac results in increased expression of CYP1A2 protein Diclofenac metabolite results in decreased activity of CYP1A2 protein [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Diclofenac
CTD
PMID:21784029 PMID:23397584 PMID:28960974
NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
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CYP1B1
cytochrome P450 family 1 subfamily B member 1
decreases activity
ISO
Diclofenac results in decreased activity of CYP1B1 protein
CTD
PMID:18420780
NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902
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CYP26A1
cytochrome P450 family 26 subfamily A member 1
decreases expression
ISO
Diclofenac results in decreased expression of CYP26A1 mRNA
CTD
PMID:26934552
NCBI chr10:93,073,475...93,077,885
Ensembl chr10:93,073,475...93,077,885
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CYP2A6
cytochrome P450 family 2 subfamily A member 6
affects expression
ISO
Diclofenac affects the expression of CYP2A5 mRNA
CTD
PMID:26934552
NCBI chr19:40,843,541...40,850,447
Ensembl chr19:40,843,541...40,850,447
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CYP2A7
cytochrome P450 family 2 subfamily A member 7
affects expression decreases activity
ISO
Diclofenac affects the expression of CYP2A4 mRNA Diclofenac results in decreased activity of CYP2A4 protein
CTD
PMID:18420780 PMID:26934552
NCBI chr19:40,875,439...40,882,231
Ensembl chr19:40,875,439...40,882,752
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CYP2B6
cytochrome P450 family 2 subfamily B member 6
decreases activity
ISO
Diclofenac results in decreased activity of CYP2B10 protein
CTD
PMID:18420780
NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398
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CYP2C19
cytochrome P450 family 2 subfamily C member 19
multiple interactions increases response to substance increases hydroxylation
EXP ISO
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Diclofenac; [CYP2C19 protein co-treated with CYP2C9 protein] results in increased hydroxylation of Diclofenac CYP2C19 protein results in increased susceptibility to Diclofenac CYP2C6 protein results in increased hydroxylation of Diclofenac CYP2C19 protein results in increased hydroxylation of Diclofenac
CTD
PMID:11911841 PMID:15486075 PMID:18511451 PMID:23397584 PMID:28762043
NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547
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CYP2C23P
cytochrome P450 family 2 subfamily C member 23, pseudogene
decreases expression
ISO
Diclofenac results in decreased expression of CYP2C23 mRNA
CTD
PMID:26934552
NCBI chr10:100,105,754...100,140,151
Ensembl chr10:100,105,754...100,140,151
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CYP2C8
cytochrome P450 family 2 subfamily C member 8
decreases activity
ISO
Diclofenac results in decreased activity of CYP2C29 protein
CTD
PMID:18420780
NCBI chr10:95,036,772...95,069,497
Ensembl chr10:95,036,772...95,069,497
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CYP2C9
cytochrome P450 family 2 subfamily C member 9
decreases hydroxylation decreases activity increases hydroxylation increases metabolic processing multiple interactions increases hydrolysis affects hydrolysis increases activity increases oxidation affects binding affects metabolic processing
EXP ISO
CYP2C9 gene polymorphism results in decreased hydroxylation of Diclofenac Diclofenac results in decreased activity of CYP2C9 protein CYP2C9 protein results in increased hydroxylation of Diclofenac CYP2C9 mRNA results in increased metabolism of Diclofenac; CYP2C9 protein results in increased metabolism of Diclofenac 1-aminobenzotriazole inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Diclofenac]; 4-methylimidazole inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]; [5-bromotryptamine analog results in decreased activity of CYP2C9 protein] which results in decreased metabolism of Diclofenac; [5-chlorotryptamine analog results in decreased activity of CYP2C9 protein] which results in decreased metabolism of Diclofenac; [5-fluoro-alpha-methyltryptamine results in decreased activity of CYP2C9 protein] which results in decreased metabolism of Diclofenac; [5-fluorotryptamine analog results in decreased activity of CYP2C9 protein] which results in decreased metabolism of Diclofenac; [5-methyltryptamine analog results in decreased activity of CYP2C9 protein] which results in decreased metabolism of Diclofenac; [7-methyltryptamine analog results in decreased activity of CYP2C9 protein] which results in decreased metabolism of Diclofenac; [[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [[Ticrynafen results in decreased activity of CYP2C9 protein] which affects the metabolism of Diclofenac] which affects the abundance of 4'-hydroxydiclofenac; [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Diclofenac; [CYP2C19 protein co-treated with CYP2C9 protein] results in increased hydroxylation of Diclofenac; [CYP2C9 mRNA results in increased metabolism of Diclofenac] which results in increased chemical synthesis of 4'-hydroxydiclofenac; [CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac; [CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased metabolism of Diclofenac; [CYP2C9 protein results in increased hydroxylation of Diclofenac] which results in increased chemical synthesis of 4'-hydroxydiclofenac; [CYP2C9 protein results in increased metabolism of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [CYP2C9 protein results in increased metabolism of Diclofenac] which results in increased chemical synthesis of 4'-hydroxydiclofenac; [CYP3A4 protein co-treated with CYP2C9 protein co-treated with UGT2B7 protein] results in increased susceptibility to Diclofenac; [CYP3A4 protein co-treated with CYP2C9 protein] results in increased susceptibility to Diclofenac; [Fluconazole results in decreased activity of CYP2C9 protein] which results in decreased metabolism of Diclofenac; [Sulfaphenazole results in decreased activity of CYP2C9 protein] which results in decreased metabolism of Diclofenac; [Ticrynafen results in decreased activity of CYP2C9 protein] which affects the metabolism of Diclofenac; [Tryptamines analog results in decreased activity of CYP2C9 protein] which results in decreased metabolism of Diclofenac; Amiodarone inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]; Benzbromarone inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]; Clotrimazole inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]; Cyclohexenes analog inhibits the reaction [CYP2C9 protein results in increased metabolism of Diclofenac]; CYP2C9 gene mutant form inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Diclofenac]; CYP2C9 protein results in increased hydroxylation of and results in increased susceptibility to Diclofenac; Fluconazole inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]; Fluvastatin inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]; Ibuprofen inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]; Ketoconazole inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]; Lansoprazole inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Diclofenac]; methysticin inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Diclofenac]; Miconazole inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]; Omeprazole inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Diclofenac]; Pantoprazole inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Diclofenac]; perfluorooctane sulfonic acid inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Diclofenac]; Piroxicam inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]; Quinine inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]; rabeprazole-thioether inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Diclofenac]; Sertraline inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]; sitaxsentan inhibits the reaction [CYP2C9 protein results in increased metabolism of Diclofenac]; Sulfaphenazole inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]; Sulfaphenazole inhibits the reaction [CYP2C9 protein results in increased metabolism of Diclofenac]; Sulfinpyrazone inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]; Ticrynafen inhibits the reaction [CYP2C9 protein results in increased metabolism of Diclofenac]; Tolbutamide inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]; Warfarin inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]; zafirlukast inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac] CYP2C9 protein results in increased hydrolysis of Diclofenac CYP2C9 gene polymorphism affects the hydrolysis of Diclofenac Diclofenac results in increased activity of CYP2C9 protein CYP2C9 protein results in increased oxidation of Diclofenac CYP2C9 protein binds to Diclofenac
CTD
PMID:9110362 PMID:9241660 PMID:9698079 PMID:10975605 PMID:10991840 PMID:11455026 PMID:12401345 PMID:12464242 PMID:12569440 PMID:15039296 PMID:15135088 PMID:15155557 PMID:15258107 PMID:15486075 PMID:15618748 PMID:15801540 PMID:15802386 PMID:15860655 PMID:16049126 PMID:16081671 PMID:17418993 PMID:17478480 PMID:17681167 PMID:17994679 PMID:18420780 PMID:19082874 PMID:19309152 PMID:20452209 PMID:21964418 PMID:22447115 PMID:23397584 PMID:23721565 PMID:24104198 PMID:24246759 PMID:25084468 PMID:25994031 PMID:26255664 PMID:26599973 PMID:27590069 PMID:28119166 PMID:28762043 PMID:29445054 PMID:29555536 PMID:31854189 PMID:33259822 PMID:35366062 PMID:35583123 PMID:35748891 More...
NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091
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CYP2D6
cytochrome P450 family 2 subfamily D member 6
multiple interactions
EXP
[[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Diclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac
CTD
PMID:23397584 PMID:24246759
NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,865
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CYP2E1
cytochrome P450 family 2 subfamily E member 1
decreases activity
EXP
Diclofenac metabolite results in decreased activity of CYP2E1 protein
CTD
PMID:28960974
NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
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CYP39A1
cytochrome P450 family 39 subfamily A member 1
increases expression
ISO
Diclofenac results in increased expression of CYP39A1 mRNA
CTD
PMID:26934552
NCBI chr 6:46,549,580...46,652,818
Ensembl chr 6:46,549,580...46,652,830
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CYP3A4
cytochrome P450 family 3 subfamily A member 4
increases expression increases response to substance increases metabolic processing multiple interactions decreases activity
EXP
Diclofenac results in increased expression of CYP3A4 mRNA CYP3A4 protein results in increased susceptibility to Diclofenac CYP3A4 protein results in increased metabolism of Diclofenac [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 5-hydroxydiclofenac; [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Diclofenac; [CYP3A4 protein co-treated with CYP2C9 protein co-treated with UGT2B7 protein] results in increased susceptibility to Diclofenac; [CYP3A4 protein co-treated with CYP2C9 protein] results in increased susceptibility to Diclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of Diclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac Diclofenac metabolite results in decreased activity of CYP3A4 protein; Diclofenac results in decreased activity of CYP3A4 protein
CTD
PMID:15135088 PMID:19022234 PMID:23397584 PMID:24104198 PMID:24246759 PMID:28762043 PMID:28960974 PMID:29027214 PMID:33259822 More...
NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
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CYP3A5
cytochrome P450 family 3 subfamily A member 5
increases expression decreases activity
ISO
Diclofenac results in increased expression of CYP3A13 mRNA Diclofenac metabolite results in decreased activity of CYP3A13 protein
CTD
PMID:26934552 PMID:28960974
NCBI chr 7:99,648,194...99,679,996
Ensembl chr 7:99,648,194...99,679,996
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CYP3A7
cytochrome P450 family 3 subfamily A member 7
increases expression decreases activity
ISO
Diclofenac results in increased expression of CYP3A13 mRNA Diclofenac metabolite results in decreased activity of CYP3A13 protein
CTD
PMID:26934552 PMID:28960974
NCBI chr 7:99,705,036...99,735,196
Ensembl chr 7:99,705,036...99,735,196
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CYP46A1
cytochrome P450 family 46 subfamily A member 1
increases hydroxylation
EXP
CYP46A1 protein results in increased hydroxylation of Diclofenac
CTD
PMID:14640697
NCBI chr14:99,684,298...99,727,301
Ensembl chr14:99,684,298...99,727,301
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CYP4A11
cytochrome P450 family 4 subfamily A member 11
affects activity
EXP
Diclofenac affects the activity of CYP4A11 protein
CTD
PMID:37499995
NCBI chr 1:46,929,188...46,941,476
Ensembl chr 1:46,929,177...46,941,484
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CYP4A22
cytochrome P450 family 4 subfamily A member 22
decreases expression
ISO
Diclofenac results in decreased expression of CYP4A31 mRNA
CTD
PMID:26934552
NCBI chr 1:47,137,441...47,149,727
Ensembl chr 1:47,137,435...47,149,727
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CYP4F22
cytochrome P450 family 4 subfamily F member 22
decreases expression
ISO
Diclofenac results in decreased expression of CYP4F39 mRNA
CTD
PMID:35537566
NCBI chr19:15,508,525...15,552,317
Ensembl chr19:15,508,525...15,552,317
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CYP4V2
cytochrome P450 family 4 subfamily V member 2
decreases expression
ISO
Diclofenac results in decreased expression of CYP4V3 mRNA
CTD
PMID:26934552
NCBI chr 4:186,191,567...186,213,463
Ensembl chr 4:186,191,567...186,213,463
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CYP51A1
cytochrome P450 family 51 subfamily A member 1
decreases activity increases expression
ISO
Diclofenac metabolite results in decreased activity of CYP51A1 protein Diclofenac results in increased expression of CYP51 mRNA
CTD
PMID:26934552 PMID:28960974
NCBI chr 7:92,112,153...92,134,803
Ensembl chr 7:92,084,987...92,134,803
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CYP7A1
cytochrome P450 family 7 subfamily A member 1
increases expression
ISO
Diclofenac results in increased expression of CYP7A1 mRNA
CTD
PMID:26934552
NCBI chr 8:58,490,178...58,500,163
Ensembl chr 8:58,490,178...58,500,163
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CYP8B1
cytochrome P450 family 8 subfamily B member 1
decreases expression
ISO
Diclofenac results in decreased expression of CYP8B1 mRNA
CTD
PMID:26934552
NCBI chr 3:42,872,192...42,875,879
Ensembl chr 3:42,856,005...42,875,898
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DAP
death associated protein
increases expression
ISO
Diclofenac results in increased expression of DAP mRNA
CTD
PMID:26934552
NCBI chr 5:10,679,230...10,761,234
Ensembl chr 5:10,679,230...10,761,234
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DBT
dihydrolipoamide branched chain transacylase E2
affects expression
EXP
Diclofenac affects the expression of DBT mRNA
CTD
PMID:24752500
NCBI chr 1:100,186,919...100,249,834
Ensembl chr 1:100,186,919...100,249,834
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DCTPP1
dCTP pyrophosphatase 1
affects expression
EXP
Diclofenac affects the expression of DCTPP1 mRNA
CTD
PMID:24752500
NCBI chr16:30,423,615...30,430,030
Ensembl chr16:30,423,615...30,430,030
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DDIT3
DNA damage inducible transcript 3
increases response to substance increases expression decreases expression
ISO EXP
DDIT3 results in increased susceptibility to Diclofenac Diclofenac results in increased expression of DDIT3 protein Diclofenac results in increased expression of DDIT3 mRNA Diclofenac results in increased expression of DDIT3 mRNA; Diclofenac results in increased expression of DDIT3 protein Diclofenac results in decreased expression of DDIT3 mRNA
CTD
PMID:18172885 PMID:20668000 PMID:24752500 PMID:27313093 PMID:27358234 PMID:35537566 More...
NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737
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DDIT4
DNA damage inducible transcript 4
increases expression
ISO
Diclofenac results in increased expression of DDIT4 mRNA
CTD
PMID:26934552
NCBI chr10:72,273,924...72,276,036
Ensembl chr10:72,273,919...72,276,036
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DDR1
discoidin domain receptor tyrosine kinase 1
affects expression
EXP
Diclofenac affects the expression of DDR1 mRNA
CTD
PMID:24752500
NCBI chr 6:30,880,970...30,900,156
Ensembl chr 6:30,876,421...30,900,156
G
DDT
D-dopachrome tautomerase
decreases expression
ISO
Diclofenac results in decreased expression of DDT mRNA
CTD
PMID:26934552
NCBI chr22:23,971,370...23,980,504
Ensembl chr22:23,970,542...23,980,525
G
DDX5
DEAD-box helicase 5
affects expression
EXP
Diclofenac affects the expression of DDX5 mRNA
CTD
PMID:24752500
NCBI chr17:64,498,254...64,506,866
Ensembl chr17:64,498,254...64,508,199
G
DECR1
2,4-dienoyl-CoA reductase 1
increases expression
ISO
Diclofenac results in increased expression of DECR1 protein
CTD
PMID:25772430
NCBI chr 8:90,001,477...90,053,633
Ensembl chr 8:90,001,405...90,053,633
G
DENND2D
DENN domain containing 2D
decreases expression
ISO
Diclofenac results in decreased expression of DENND2D mRNA
CTD
PMID:35537566
NCBI chr 1:111,185,969...111,204,578
Ensembl chr 1:111,185,969...111,204,535
G
DERL1
derlin 1
increases expression
ISO
Diclofenac results in increased expression of DERL1 mRNA
CTD
PMID:26934552
NCBI chr 8:123,013,170...123,042,302
Ensembl chr 8:123,013,170...123,042,302
G
DERL3
derlin 3
increases expression
ISO
Diclofenac results in increased expression of DERL3 mRNA
CTD
PMID:26934552
NCBI chr22:23,834,503...23,839,006
Ensembl chr22:23,834,503...23,839,128
G
DFFA
DNA fragmentation factor subunit alpha
affects expression
EXP
Diclofenac affects the expression of DFFA mRNA
CTD
PMID:24752500
NCBI chr 1:10,456,522...10,472,529
Ensembl chr 1:10,456,522...10,472,529
G
DHCR24
24-dehydrocholesterol reductase
increases expression
ISO
Diclofenac results in increased expression of DHCR24 mRNA
CTD
PMID:26934552
NCBI chr 1:54,849,627...54,887,195
Ensembl chr 1:54,849,627...54,887,195
G
DHFR
dihydrofolate reductase
affects expression
EXP
Diclofenac affects the expression of DHFR mRNA
CTD
PMID:24752500
NCBI chr 5:80,626,226...80,654,983
Ensembl chr 5:80,626,226...80,654,983
G
DHRS3
dehydrogenase/reductase 3
decreases expression
ISO
Diclofenac results in decreased expression of DHRS3 mRNA
CTD
PMID:35537566
NCBI chr 1:12,567,910...12,618,210
Ensembl chr 1:12,567,909...12,620,133
G
DKK1
dickkopf WNT signaling pathway inhibitor 1
affects expression
EXP
Diclofenac affects the expression of DKK1 mRNA
CTD
PMID:24752500
NCBI chr10:52,314,281...52,317,657
Ensembl chr10:52,314,281...52,318,042
G
DNAJA1
DnaJ heat shock protein family (Hsp40) member A1
affects expression
EXP
Diclofenac affects the expression of DNAJA1 mRNA
CTD
PMID:24752500
NCBI chr 9:33,025,273...33,039,907
Ensembl chr 9:33,025,273...33,039,907
G
DNAJA2
DnaJ heat shock protein family (Hsp40) member A2
affects expression
EXP
Diclofenac affects the expression of DNAJA2 mRNA
CTD
PMID:24752500
NCBI chr16:46,955,362...46,973,674
Ensembl chr16:46,955,362...46,973,674
G
DNAJA3
DnaJ heat shock protein family (Hsp40) member A3
affects expression decreases expression
EXP ISO
Diclofenac affects the expression of DNAJA3 mRNA Diclofenac results in decreased expression of DNAJA3 mRNA
CTD
PMID:24752500 PMID:26934552
NCBI chr16:4,425,868...4,456,775
Ensembl chr16:4,425,805...4,456,775
G
DNAJB1
DnaJ heat shock protein family (Hsp40) member B1
affects expression
EXP
Diclofenac affects the expression of DNAJB1 mRNA
CTD
PMID:24752500
NCBI chr19:14,514,769...14,560,391
Ensembl chr19:14,514,769...14,560,391
G
DNAJB14
DnaJ heat shock protein family (Hsp40) member B14
affects expression
EXP
Diclofenac affects the expression of DNAJB14 mRNA
CTD
PMID:24752500
NCBI chr 4:99,896,248...99,946,618
Ensembl chr 4:99,896,248...99,946,618
G
DNAJB4
DnaJ heat shock protein family (Hsp40) member B4
affects expression
EXP
Diclofenac affects the expression of DNAJB4 mRNA
CTD
PMID:24752500
NCBI chr 1:77,979,175...78,017,964
Ensembl chr 1:77,979,175...78,017,964
G
DNAJB6
DnaJ heat shock protein family (Hsp40) member B6
affects expression
EXP
Diclofenac affects the expression of DNAJB6 mRNA
CTD
PMID:24752500
NCBI chr 7:157,337,004...157,417,439
Ensembl chr 7:157,335,381...157,417,439
G
DNAJB7
DnaJ heat shock protein family (Hsp40) member B7
increases expression
ISO
Diclofenac results in increased expression of DNAJB7 mRNA
CTD
PMID:30723492
NCBI chr22:40,859,549...40,862,113
Ensembl chr22:40,859,549...40,862,113
G
DNAJB9
DnaJ heat shock protein family (Hsp40) member B9
affects expression increases expression
EXP ISO
Diclofenac affects the expression of DNAJB9 mRNA Diclofenac results in increased expression of DNAJB9 mRNA
CTD
PMID:24752500 PMID:26934552
NCBI chr 7:108,569,874...108,574,850
Ensembl chr 7:108,569,867...108,574,850
G
DNAJC10
DnaJ heat shock protein family (Hsp40) member C10
affects expression increases expression
EXP ISO
Diclofenac affects the expression of DNAJC10 mRNA Diclofenac results in increased expression of DNAJC10 mRNA
CTD
PMID:24752500 PMID:26934552
NCBI chr 2:182,716,257...182,794,464
Ensembl chr 2:182,716,255...182,794,464
G
DNAJC11
DnaJ heat shock protein family (Hsp40) member C11
affects expression
EXP
Diclofenac affects the expression of DNAJC11 mRNA
CTD
PMID:24752500
NCBI chr 1:6,634,170...6,701,816
Ensembl chr 1:6,634,168...6,701,924
G
DNAJC12
DnaJ heat shock protein family (Hsp40) member C12
increases expression decreases expression
ISO
Diclofenac results in increased expression of DNAJC12 mRNA Diclofenac results in decreased expression of DNAJC12 mRNA
CTD
PMID:26934552
NCBI chr10:67,796,669...67,838,188
Ensembl chr10:67,796,669...67,838,188
G
DNAJC15
DnaJ heat shock protein family (Hsp40) member C15
affects expression
EXP
Diclofenac affects the expression of DNAJC15 mRNA
CTD
PMID:24752500
NCBI chr13:43,023,586...43,114,213
Ensembl chr13:43,023,203...43,114,213
G
DNAJC18
DnaJ heat shock protein family (Hsp40) member C18
affects expression
EXP
Diclofenac affects the expression of DNAJC18 mRNA
CTD
PMID:24752500
NCBI chr 5:139,410,203...139,439,525
Ensembl chr 5:139,408,588...139,444,491
G
DNAJC21
DnaJ heat shock protein family (Hsp40) member C21
affects expression
EXP
Diclofenac affects the expression of DNAJC21 mRNA
CTD
PMID:24752500
NCBI chr 5:34,929,559...34,958,964
Ensembl chr 5:34,929,559...34,958,964
G
DNAJC3
DnaJ heat shock protein family (Hsp40) member C3
increases expression
ISO
Diclofenac results in increased expression of DNAJC3 mRNA
CTD
PMID:26934552
NCBI chr13:95,677,139...95,794,988
Ensembl chr13:95,677,139...95,794,988
G
DNAJC5
DnaJ heat shock protein family (Hsp40) member C5
affects expression
EXP
Diclofenac affects the expression of DNAJC5 mRNA
CTD
PMID:24752500
NCBI chr20:63,895,126...63,936,011
Ensembl chr20:63,895,126...63,936,031
G
DNAJC6
DnaJ heat shock protein family (Hsp40) member C6
affects expression
EXP
Diclofenac affects the expression of DNAJC6 mRNA
CTD
PMID:24752500
NCBI chr 1:65,264,749...65,415,871
Ensembl chr 1:65,248,219...65,415,871
G
DNAJC7
DnaJ heat shock protein family (Hsp40) member C7
affects expression
EXP
Diclofenac affects the expression of DNAJC7 mRNA
CTD
PMID:24752500
NCBI chr17:41,976,435...42,017,439
Ensembl chr17:41,976,421...42,021,376
G
DNAJC8
DnaJ heat shock protein family (Hsp40) member C8
affects expression
EXP
Diclofenac affects the expression of DNAJC8 mRNA
CTD
PMID:24752500
NCBI chr 1:28,200,278...28,233,029
Ensembl chr 1:28,199,456...28,233,029
G
DNAJC9
DnaJ heat shock protein family (Hsp40) member C9
affects expression
EXP
Diclofenac affects the expression of DNAJC9 mRNA
CTD
PMID:24752500
NCBI chr10:73,232,272...73,247,255
Ensembl chr10:73,183,362...73,247,255
G
DND1
DND microRNA-mediated repression inhibitor 1
increases expression
ISO
Diclofenac results in increased expression of DND1 mRNA
CTD
PMID:35537566
NCBI chr 5:140,670,794...140,673,576
Ensembl chr 5:140,670,794...140,673,576
G
DNER
delta/notch like EGF repeat containing
decreases expression
ISO
Diclofenac results in decreased expression of DNER mRNA
CTD
PMID:35537566
NCBI chr 2:229,357,629...229,714,555
Ensembl chr 2:229,357,629...229,714,555
G
DPYSL2
dihydropyrimidinase like 2
affects expression
EXP
Diclofenac affects the expression of DPYSL2 mRNA
CTD
PMID:24752500
NCBI chr 8:26,514,031...26,658,175
Ensembl chr 8:26,514,031...26,658,178
G
DRD1
dopamine receptor D1
increases expression
ISO
Diclofenac results in increased expression of DRD1 mRNA
CTD
PMID:26934552
NCBI chr 5:175,440,036...175,444,182
Ensembl chr 5:175,440,036...175,444,182
G
DTYMK
deoxythymidylate kinase
affects expression
EXP
Diclofenac affects the expression of DTYMK mRNA
CTD
PMID:24752500
NCBI chr 2:241,675,747...241,686,815
Ensembl chr 2:241,675,747...241,686,944
G
DUSP1
dual specificity phosphatase 1
affects expression decreases expression
EXP ISO
Diclofenac affects the expression of DUSP1 mRNA Diclofenac results in decreased expression of DUSP1 mRNA
CTD
PMID:24752500 PMID:26934552
NCBI chr 5:172,768,096...172,771,195
Ensembl chr 5:172,768,096...172,771,195
G
DUT
deoxyuridine triphosphatase
affects expression
EXP
Diclofenac affects the expression of DUT mRNA
CTD
PMID:24752500
NCBI chr15:48,331,095...48,343,373
Ensembl chr15:48,331,011...48,343,373
G
DYNC1I1
dynein cytoplasmic 1 intermediate chain 1
increases expression
ISO
Diclofenac results in increased expression of DYNC1I1 mRNA
CTD
PMID:30723492
NCBI chr 7:95,772,554...96,110,322
Ensembl chr 7:95,772,506...96,110,322
G
E2F1
E2F transcription factor 1
affects expression
EXP
Diclofenac affects the expression of E2F1 mRNA
CTD
PMID:24752500
NCBI chr20:33,675,477...33,686,385
Ensembl chr20:33,675,477...33,686,385
G
E2F2
E2F transcription factor 2
affects expression
EXP
Diclofenac affects the expression of E2F2 mRNA
CTD
PMID:24752500
NCBI chr 1:23,505,212...23,531,233
Ensembl chr 1:23,506,438...23,531,233
G
E2F5
E2F transcription factor 5
affects expression
EXP
Diclofenac affects the expression of E2F5 mRNA
CTD
PMID:24752500
NCBI chr 8:85,177,154...85,214,518
Ensembl chr 8:85,177,154...85,217,158
G
EBLN1
endogenous Bornavirus like nucleoprotein 1
increases expression
ISO
Diclofenac results in increased expression of IGKV8-24 mRNA
CTD
PMID:30723492
NCBI chr10:22,208,475...22,218,015
Ensembl chr10:22,208,475...22,218,015
G
ECM1
extracellular matrix protein 1
decreases expression
ISO
Diclofenac results in decreased expression of ECM1 mRNA
CTD
PMID:26934552
NCBI chr 1:150,508,109...150,513,789
Ensembl chr 1:150,508,062...150,513,789
G
ECT2
epithelial cell transforming 2
increases expression
ISO
Diclofenac results in increased expression of ECT2 mRNA
CTD
PMID:26934552
NCBI chr 3:172,750,726...172,829,265
Ensembl chr 3:172,750,682...172,821,474
G
EDEM1
ER degradation enhancing alpha-mannosidase like protein 1
increases expression
ISO
Diclofenac results in increased expression of EDEM1 mRNA
CTD
PMID:26934552
NCBI chr 3:5,187,707...5,219,958
Ensembl chr 3:5,187,646...5,219,958
G
EDIL3
EGF like repeats and discoidin domains 3
decreases expression
ISO
Diclofenac results in decreased expression of EDIL3 mRNA
CTD
PMID:26934552
NCBI chr 5:83,940,554...84,384,880
Ensembl chr 5:83,940,554...84,384,880
G
EDN1
endothelin 1
multiple interactions
ISO
Diclofenac inhibits the reaction [EDN1 protein results in decreased transport of Potassium]
CTD
PMID:15083534
NCBI chr 6:12,230,516...12,297,194
Ensembl chr 6:12,290,361...12,297,194
G
EEF2K
eukaryotic elongation factor 2 kinase
decreases expression
ISO
Diclofenac results in decreased expression of EEF2K mRNA
CTD
PMID:35537566
NCBI chr16:22,206,278...22,288,738
Ensembl chr16:22,206,278...22,288,738
G
EGF
epidermal growth factor
increases expression
ISO
Diclofenac results in increased expression of EGF protein
CTD
PMID:23506792
NCBI chr 4:109,912,883...110,013,766
Ensembl chr 4:109,912,883...110,013,766
G
EGFR
epidermal growth factor receptor
increases expression
ISO
Diclofenac results in increased expression of EGFR mRNA
CTD
PMID:26934552
NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628
G
EGR1
early growth response 1
increases expression affects expression
EXP ISO
Diclofenac results in increased expression of EGR1 mRNA Diclofenac affects the expression of EGR1 mRNA
CTD
PMID:15509713 PMID:26934552
NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303
G
EIF1
eukaryotic translation initiation factor 1
affects expression
EXP
Diclofenac affects the expression of EIF1 mRNA
CTD
PMID:24752500
NCBI chr17:41,688,885...41,692,668
Ensembl chr17:41,688,885...41,692,668
G
EIF1AX
eukaryotic translation initiation factor 1A X-linked
affects expression
EXP
Diclofenac affects the expression of EIF1AX mRNA
CTD
PMID:24752500
NCBI chr X:20,124,525...20,141,838
Ensembl chr X:20,124,525...20,141,838
G
EIF2A
eukaryotic translation initiation factor 2A
affects expression
EXP
Diclofenac affects the expression of EIF2A mRNA
CTD
PMID:24752500
NCBI chr 3:150,546,787...150,586,016
Ensembl chr 3:150,546,678...150,586,016
G
EIF2AK1
eukaryotic translation initiation factor 2 alpha kinase 1
affects expression decreases expression
EXP ISO
Diclofenac affects the expression of EIF2AK1 mRNA Diclofenac results in decreased expression of EIF2AK1 mRNA
CTD
PMID:24752500 PMID:26934552
NCBI chr 7:6,022,247...6,059,175
Ensembl chr 7:6,022,247...6,059,175
G
EIF2AK3
eukaryotic translation initiation factor 2 alpha kinase 3
affects expression increases expression increases phosphorylation multiple interactions increases activity
EXP ISO
Diclofenac affects the expression of EIF2AK3 mRNA Diclofenac results in increased expression of EIF2AK3 mRNA Diclofenac results in increased phosphorylation of EIF2AK3 protein 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Diclofenac results in increased phosphorylation of EIF2AK3 protein]; 2-aminoethoxydiphenyl borate inhibits the reaction [Diclofenac results in increased phosphorylation of EIF2AK3 protein]; Calcium promotes the reaction [Diclofenac results in increased phosphorylation of EIF2AK3 protein] Diclofenac results in increased activity of EIF2AK3 protein
CTD
PMID:24752500 PMID:26609140 PMID:26934552
NCBI chr 2:88,556,741...88,628,145
Ensembl chr 2:88,556,741...88,691,518
G
EIF2AK4
eukaryotic translation initiation factor 2 alpha kinase 4
affects expression
EXP
Diclofenac affects the expression of EIF2AK4 mRNA
CTD
PMID:24752500
NCBI chr15:39,934,115...40,035,591
Ensembl chr15:39,934,115...40,035,591
G
EIF2B1
eukaryotic translation initiation factor 2B subunit alpha
affects expression
EXP
Diclofenac affects the expression of EIF2B1 mRNA
CTD
PMID:24752500
NCBI chr12:123,620,406...123,633,686
Ensembl chr12:123,620,406...123,633,766
G
EIF2S1
eukaryotic translation initiation factor 2 subunit alpha
affects expression multiple interactions
EXP
Diclofenac affects the expression of EIF2S1 mRNA [TNF protein co-treated with Diclofenac] results in increased phosphorylation of EIF2S1 protein
CTD
PMID:24752500 PMID:27313093
NCBI chr14:67,360,328...67,386,516
Ensembl chr14:67,360,328...67,386,516
G
EIF2S2
eukaryotic translation initiation factor 2 subunit beta
affects expression
EXP
Diclofenac affects the expression of EIF2S2 mRNA
CTD
PMID:24752500
NCBI chr20:34,088,309...34,112,243
Ensembl chr20:34,088,309...34,112,243
G
EIF3A
eukaryotic translation initiation factor 3 subunit A
affects expression
EXP
Diclofenac affects the expression of EIF3A mRNA
CTD
PMID:24752500
NCBI chr10:119,033,670...119,080,817
Ensembl chr10:119,033,670...119,080,817
G
EIF3B
eukaryotic translation initiation factor 3 subunit B
affects expression
EXP
Diclofenac affects the expression of EIF3B mRNA
CTD
PMID:24752500
NCBI chr 7:2,354,086...2,380,745
Ensembl chr 7:2,354,086...2,380,745
G
EIF3C
eukaryotic translation initiation factor 3 subunit C
affects expression
EXP
Diclofenac affects the expression of EIF3C mRNA
CTD
PMID:24752500
NCBI chr16:28,688,558...28,735,730
Ensembl chr16:28,688,558...28,735,727
G
EIF4A1
eukaryotic translation initiation factor 4A1
affects expression
EXP
Diclofenac affects the expression of EIF4A1 mRNA
CTD
PMID:24752500
NCBI chr17:7,572,825...7,579,006
Ensembl chr17:7,572,824...7,579,006
G
EIF4A2
eukaryotic translation initiation factor 4A2
affects expression
EXP
Diclofenac affects the expression of EIF4A2 mRNA
CTD
PMID:24752500
NCBI chr 3:186,783,577...186,789,897
Ensembl chr 3:186,783,205...186,789,897
G
EIF4EBP1
eukaryotic translation initiation factor 4E binding protein 1
increases expression decreases expression affects expression
ISO EXP
Diclofenac results in increased expression of EIF4EBP1 mRNA Diclofenac results in decreased expression of EIF4EBP1 mRNA Diclofenac affects the expression of EIF4EBP1 mRNA
CTD
PMID:18172885 PMID:24752500 PMID:35537566
NCBI chr 8:38,030,534...38,060,365
Ensembl chr 8:38,030,534...38,060,365
G
EIF4G1
eukaryotic translation initiation factor 4 gamma 1
affects expression
EXP
Diclofenac affects the expression of EIF4G1 mRNA
CTD
PMID:24752500
NCBI chr 3:184,314,606...184,335,358
Ensembl chr 3:184,314,495...184,335,358
G
EIF4G3
eukaryotic translation initiation factor 4 gamma 3
affects expression
EXP
Diclofenac affects the expression of EIF4G3 mRNA
CTD
PMID:24752500
NCBI chr 1:20,806,292...21,176,897
Ensembl chr 1:20,806,292...21,177,285
G
EIF5
eukaryotic translation initiation factor 5
affects expression
EXP
Diclofenac affects the expression of EIF5 mRNA
CTD
PMID:24752500
NCBI chr14:103,334,237...103,345,025
Ensembl chr14:103,333,544...103,345,025
G
ELF2
E74 like ETS transcription factor 2
affects expression
EXP
Diclofenac affects the expression of ELF2 mRNA
CTD
PMID:24752500
NCBI chr 4:139,057,220...139,177,915
Ensembl chr 4:139,028,112...139,177,218
G
ELF3
E74 like ETS transcription factor 3
affects expression
EXP
Diclofenac affects the expression of ELF3 mRNA
CTD
PMID:24752500
NCBI chr 1:202,010,587...202,017,183
Ensembl chr 1:202,007,945...202,017,183
G
ELOVL2
ELOVL fatty acid elongase 2
affects expression
EXP
Diclofenac affects the expression of ELOVL2 mRNA
CTD
PMID:24752500
NCBI chr 6:10,980,759...11,044,305
Ensembl chr 6:10,980,759...11,044,305
G
ELOVL6
ELOVL fatty acid elongase 6
increases expression
ISO
Diclofenac results in increased expression of ELOVL6 mRNA
CTD
PMID:35537566
NCBI chr 4:110,045,846...110,199,202
Ensembl chr 4:110,045,846...110,199,199
G
EME2
essential meiotic structure-specific endonuclease subunit 2
increases expression
ISO
Diclofenac results in increased expression of EME2 mRNA
CTD
PMID:26934552
NCBI chr16:1,772,810...1,781,702
Ensembl chr16:1,772,810...1,781,708
G
ENDOG
endonuclease G
affects expression
EXP
Diclofenac affects the expression of ENDOG mRNA
CTD
PMID:24752500
NCBI chr 9:128,818,500...128,822,676
Ensembl chr 9:128,818,500...128,822,676
G
ENO1
enolase 1
increases expression
ISO
Diclofenac results in increased expression of ENO1 mRNA
CTD
PMID:26934552
NCBI chr 1:8,861,000...8,878,686
Ensembl chr 1:8,861,000...8,879,190
G
ENPP1
ectonucleotide pyrophosphatase/phosphodiesterase 1
affects expression
EXP
Diclofenac affects the expression of ENPP1 mRNA
CTD
PMID:24752500
NCBI chr 6:131,808,020...131,895,155
Ensembl chr 6:131,808,016...131,895,155
G
ENPP2
ectonucleotide pyrophosphatase/phosphodiesterase 2
increases expression
ISO
Diclofenac results in increased expression of ENPP2 mRNA
CTD
PMID:26934552
NCBI chr 8:119,557,086...119,673,390
Ensembl chr 8:119,557,086...119,673,453
G
ENTPD4
ectonucleoside triphosphate diphosphohydrolase 4
affects expression
EXP
Diclofenac affects the expression of ENTPD4 mRNA
CTD
PMID:24752500
NCBI chr 8:23,429,162...23,457,647
Ensembl chr 8:23,385,783...23,457,695
G
ENTPD5
ectonucleoside triphosphate diphosphohydrolase 5 (inactive)
affects expression
EXP
Diclofenac affects the expression of ENTPD5 mRNA
CTD
PMID:24752500
NCBI chr14:73,955,329...74,019,288
Ensembl chr14:73,958,010...74,019,399
G
ENTPD7
ectonucleoside triphosphate diphosphohydrolase 7
affects expression
EXP
Diclofenac affects the expression of ENTPD7 mRNA
CTD
PMID:24752500
NCBI chr10:99,659,509...99,711,241
Ensembl chr10:99,659,509...99,711,241
G
EPAS1
endothelial PAS domain protein 1
decreases expression
EXP
Diclofenac results in decreased expression of EPAS1 protein
CTD
PMID:12912967
NCBI chr 2:46,297,407...46,386,697
Ensembl chr 2:46,293,667...46,386,697
G
EPHX1
epoxide hydrolase 1
decreases expression
ISO
Diclofenac results in decreased expression of EPHX1 mRNA
CTD
PMID:17202759
NCBI chr 1:225,810,124...225,845,563
Ensembl chr 1:225,810,124...225,845,563
G
EPN2
epsin 2
affects expression
EXP
Diclofenac affects the expression of EPN2 mRNA
CTD
PMID:24752500
NCBI chr17:19,237,366...19,336,715
Ensembl chr17:19,215,615...19,336,715
G
EPN3
epsin 3
affects expression
EXP
Diclofenac affects the expression of EPN3 mRNA
CTD
PMID:24752500
NCBI chr17:50,532,735...50,543,750
Ensembl chr17:50,532,682...50,543,750
G
EPO
erythropoietin
affects expression
EXP
Diclofenac affects the expression of EPO mRNA
CTD
PMID:24752500
NCBI chr 7:100,720,468...100,723,700
Ensembl chr 7:100,720,468...100,723,700
G
EREG
epiregulin
increases expression
EXP
Diclofenac results in increased expression of EREG mRNA
CTD
PMID:32816093
NCBI chr 4:74,365,145...74,388,749
Ensembl chr 4:74,365,145...74,388,749
G
ERN1
endoplasmic reticulum to nucleus signaling 1
affects expression
EXP
Diclofenac affects the expression of ERN1 mRNA
CTD
PMID:24752500
NCBI chr17:64,039,142...64,130,144
Ensembl chr17:64,039,080...64,130,819
G
ERO1A
endoplasmic reticulum oxidoreductase 1 alpha
increases expression
ISO
Diclofenac results in increased expression of ERO1A mRNA
CTD
PMID:26934552
NCBI chr14:52,639,915...52,695,558
Ensembl chr14:52,639,915...52,695,900
G
ESR1
estrogen receptor 1
affects activity
EXP
Diclofenac affects the activity of ESR1 protein
CTD
PMID:29777833
NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619
G
ETNPPL
ethanolamine-phosphate phospho-lyase
decreases expression
ISO
Diclofenac results in decreased expression of ETNPPL mRNA
CTD
PMID:26934552
NCBI chr 4:108,742,053...108,763,053
Ensembl chr 4:108,742,048...108,763,054
G
EVI5
ecotropic viral integration site 5
decreases expression
ISO
Diclofenac results in decreased expression of EVI5 mRNA
CTD
PMID:35537566
NCBI chr 1:92,508,696...92,792,410
Ensembl chr 1:92,508,696...92,792,404
G
EXTL1
exostosin like glycosyltransferase 1
decreases expression
ISO
Diclofenac results in decreased expression of EXTL1 mRNA
CTD
PMID:35537566
NCBI chr 1:26,021,775...26,036,464
Ensembl chr 1:26,019,884...26,036,464
G
EYA4
EYA transcriptional coactivator and phosphatase 4
decreases expression
ISO
Diclofenac results in decreased expression of EYA4 mRNA
CTD
PMID:26934552
NCBI chr 6:133,240,593...133,532,128
Ensembl chr 6:133,240,514...133,532,128
G
F13A1
coagulation factor XIII A chain
increases expression
ISO
Diclofenac results in increased expression of F13A1 mRNA
CTD
PMID:26934552
NCBI chr 6:6,144,084...6,320,662
Ensembl chr 6:6,144,084...6,321,013
G
FAAP24
FA core complex associated protein 24
increases expression
ISO
Diclofenac results in increased expression of FAAP24 mRNA
CTD
PMID:26934552
NCBI chr19:32,972,242...32,978,229
Ensembl chr19:32,972,209...32,978,229
G
FABP1
fatty acid binding protein 1
decreases expression increases expression
EXP ISO
Diclofenac results in decreased expression of FABP1 mRNA Diclofenac results in increased expression of FABP1 protein
CTD
PMID:19022234 PMID:23506792
NCBI chr 2:88,122,982...88,128,062
Ensembl chr 2:88,122,982...88,128,062
G
FABP2
fatty acid binding protein 2
decreases expression
ISO
Diclofenac results in decreased expression of FABP2 mRNA
CTD
PMID:19022234 PMID:26934552
NCBI chr 4:119,317,250...119,322,138
Ensembl chr 4:119,317,250...119,322,138
G
FABP4
fatty acid binding protein 4
decreases expression
ISO
Diclofenac results in decreased expression of FABP4 mRNA
CTD
PMID:35537566
NCBI chr 8:81,478,419...81,483,233
Ensembl chr 8:81,478,419...81,483,236
G
FABP5
fatty acid binding protein 5
increases expression
ISO
Diclofenac results in increased expression of FABP5 mRNA
CTD
PMID:26934552
NCBI chr 8:81,280,536...81,284,775
Ensembl chr 8:81,280,536...81,284,777
G
FADS1
fatty acid desaturase 1
decreases expression
ISO
Diclofenac results in decreased expression of FADS1 mRNA
CTD
PMID:26934552
NCBI chr11:61,799,627...61,817,003
Ensembl chr11:61,799,627...61,829,318
G
FANCB
FA complementation group B
affects expression
EXP
Diclofenac affects the expression of FANCB mRNA
CTD
PMID:24752500
NCBI chr X:14,689,524...14,873,069
Ensembl chr X:14,690,388...14,873,255
G
FANCC
FA complementation group C
affects expression
EXP
Diclofenac affects the expression of FANCC mRNA
CTD
PMID:24752500
NCBI chr 9:95,099,054...95,317,709
Ensembl chr 9:95,099,054...95,426,796
G
FANCE
FA complementation group E
increases expression
ISO
Diclofenac results in increased expression of FANCE mRNA
CTD
PMID:26934552
NCBI chr 6:35,452,338...35,467,102
Ensembl chr 6:35,452,338...35,467,104
G
FANCF
FA complementation group F
affects expression
EXP
Diclofenac affects the expression of FANCF mRNA
CTD
PMID:24752500
NCBI chr11:22,622,533...22,625,823
Ensembl chr11:22,622,533...22,625,823
G
FANCG
FA complementation group G
affects expression
EXP
Diclofenac affects the expression of FANCG mRNA
CTD
PMID:24752500
NCBI chr 9:35,073,839...35,079,942
Ensembl chr 9:35,073,835...35,080,004
G
FANCL
FA complementation group L
affects expression
EXP
Diclofenac affects the expression of FANCL mRNA
CTD
PMID:24752500
NCBI chr 2:58,159,243...58,241,380
Ensembl chr 2:58,159,243...58,241,410
G
FANCM
FA complementation group M
affects expression
EXP
Diclofenac affects the expression of FANCM mRNA
CTD
PMID:24752500
NCBI chr14:45,135,930...45,200,890
Ensembl chr14:45,135,930...45,200,890
G
FAS
Fas cell surface death receptor
affects expression increases expression
EXP ISO
Diclofenac affects the expression of FAS mRNA Diclofenac results in increased expression of FAS mRNA
CTD
PMID:24752500 PMID:26934552
NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605
G
FASLG
Fas ligand
increases expression
ISO
Diclofenac results in increased expression of FASL mRNA
CTD
PMID:22285467
NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876
G
FASN
fatty acid synthase
decreases expression
ISO
Diclofenac results in decreased expression of FASN mRNA
CTD
PMID:19022234
NCBI chr17:82,078,338...82,098,236
Ensembl chr17:82,078,338...82,098,294
G
FBXO33
F-box protein 33
increases expression
ISO
Diclofenac results in increased expression of FBXO33 mRNA
CTD
PMID:35537566
NCBI chr14:39,397,684...39,432,433
Ensembl chr14:39,397,684...39,432,466
G
FBXO5
F-box protein 5
decreases expression
ISO
Diclofenac results in decreased expression of FBXO5 mRNA
CTD
PMID:35537566
NCBI chr 6:152,970,535...152,983,579
Ensembl chr 6:152,970,519...152,983,579
G
FCER1G
Fc epsilon receptor Ig
increases expression
ISO
Diclofenac results in increased expression of FCER1G mRNA
CTD
PMID:26934552
NCBI chr 1:161,215,295...161,219,245
Ensembl chr 1:161,215,234...161,220,699
G
FCGR2B
Fc gamma receptor IIb
decreases expression
ISO
Diclofenac results in decreased expression of FCGR2B mRNA
CTD
PMID:35537566
NCBI chr 1:161,647,243...161,678,654
Ensembl chr 1:161,663,143...161,678,654
G
FEN1
flap structure-specific endonuclease 1
increases expression
ISO
Diclofenac results in increased expression of FEN1 mRNA
CTD
PMID:26934552
NCBI chr11:61,792,911...61,797,238
Ensembl chr11:61,792,911...61,797,238
G
FER
FER tyrosine kinase
affects expression
EXP
Diclofenac affects the expression of FER mRNA
CTD
PMID:24752500
NCBI chr 5:108,747,897...109,196,841
Ensembl chr 5:108,747,841...109,196,841
G
FERMT1
FERM domain containing kindlin 1
increases expression
ISO
Diclofenac results in increased expression of FERMT1 mRNA
CTD
PMID:30723492
NCBI chr20:6,074,845...6,123,030
Ensembl chr20:6,074,845...6,123,214
G
FGB
fibrinogen beta chain
multiple interactions increases expression
ISO
[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of FGB protein Diclofenac results in increased expression of FGB mRNA
CTD
PMID:25772430 PMID:26934552
NCBI chr 4:154,562,980...154,572,807
Ensembl chr 4:154,563,011...154,572,807
G
FGF1
fibroblast growth factor 1
decreases expression
ISO
Diclofenac results in decreased expression of FGF1 mRNA
CTD
PMID:26934552
NCBI chr 5:142,592,178...142,698,070
Ensembl chr 5:142,592,178...142,698,070
G
FGF3
fibroblast growth factor 3
increases expression
ISO
Diclofenac results in increased expression of FGF3 mRNA
CTD
PMID:26934552
NCBI chr11:69,809,968...69,819,416
Ensembl chr11:69,809,968...69,819,416
G
FGFR1
fibroblast growth factor receptor 1
affects expression
EXP
Diclofenac affects the expression of FGFR1 mRNA
CTD
PMID:24752500
NCBI chr 8:38,411,143...38,468,635
Ensembl chr 8:38,400,215...38,468,834
G
FGFR1OP2
FGFR1 oncogene partner 2
decreases expression
ISO
Diclofenac results in decreased expression of FGFR1OP2 mRNA
CTD
PMID:26934552
NCBI chr12:26,938,470...26,966,648
Ensembl chr12:26,938,470...26,966,650
G
FGG
fibrinogen gamma chain
multiple interactions decreases expression
ISO
[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of FGG protein; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of FGG protein]; lipopolysaccharide, E coli O55-B5 promotes the reaction [Diclofenac results in decreased expression of FGG protein]
CTD
PMID:25772430
NCBI chr 4:154,604,136...154,612,656
Ensembl chr 4:154,604,134...154,612,967
G
FGL1
fibrinogen like 1
increases expression
ISO
Diclofenac results in increased expression of FGL1 mRNA
CTD
PMID:26934552
NCBI chr 8:17,864,389...17,895,538
Ensembl chr 8:17,864,380...17,910,365
G
FMOD
fibromodulin
decreases expression
ISO
Diclofenac results in decreased expression of FMOD mRNA
CTD
PMID:26934552
NCBI chr 1:203,340,628...203,351,122
Ensembl chr 1:203,340,628...203,351,758
G
FN1
fibronectin 1
increases expression
ISO
Diclofenac results in increased expression of FN1 mRNA; Diclofenac results in increased expression of FN1 protein
CTD
PMID:26934552
NCBI chr 2:215,360,865...215,436,068
Ensembl chr 2:215,360,440...215,436,073
G
FNBP1
formin binding protein 1
affects expression
EXP
Diclofenac affects the expression of FNBP1 mRNA
CTD
PMID:24752500
NCBI chr 9:129,887,187...130,053,879
Ensembl chr 9:129,887,187...130,043,189
G
FNDC3B
fibronectin type III domain containing 3B
increases expression
ISO
Diclofenac results in increased expression of FNDC3B mRNA
CTD
PMID:26934552
NCBI chr 3:172,039,578...172,401,669
Ensembl chr 3:172,039,578...172,401,669
G
FNIP1
folliculin interacting protein 1
decreases expression
ISO
Diclofenac results in decreased expression of FNIP1 mRNA
CTD
PMID:26934552
NCBI chr 5:131,641,714...131,797,017
Ensembl chr 5:131,641,714...131,797,017
G
FNIP2
folliculin interacting protein 2
decreases expression
ISO
Diclofenac results in decreased expression of FNIP2 mRNA
CTD
PMID:26934552
NCBI chr 4:158,769,026...158,908,050
Ensembl chr 4:158,769,026...158,908,050
G
FOS
Fos proto-oncogene, AP-1 transcription factor subunit
increases expression affects expression
EXP
Diclofenac results in increased expression of FOS mRNA Diclofenac affects the expression of FOS mRNA
CTD
PMID:12730611 PMID:24752500
NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
G
FOSL2
FOS like 2, AP-1 transcription factor subunit
increases expression
ISO
Diclofenac results in increased expression of FOSL2 mRNA
CTD
PMID:26934552
NCBI chr 2:28,392,858...28,417,317
Ensembl chr 2:28,392,448...28,417,317
G
FOXA1
forkhead box A1
affects expression
EXP
Diclofenac affects the expression of FOXA1 mRNA
CTD
PMID:24752500
NCBI chr14:37,589,552...37,595,249
Ensembl chr14:37,589,552...37,596,059
G
FOXA3
forkhead box A3
increases expression
ISO
Diclofenac results in increased expression of FOXA3 mRNA
CTD
PMID:26934552
NCBI chr19:45,864,326...45,873,797
Ensembl chr19:45,863,989...45,873,797
G
FOXO1
forkhead box O1
affects expression
EXP
Diclofenac affects the expression of FOXO1 mRNA
CTD
PMID:24752500
NCBI chr13:40,555,667...40,666,641
Ensembl chr13:40,555,667...40,666,641
G
FOXO3
forkhead box O3
affects expression decreases expression
EXP ISO
Diclofenac affects the expression of FOXO3 mRNA Diclofenac results in decreased expression of FOXO3 mRNA
CTD
PMID:24752500 PMID:26934552
NCBI chr 6:108,559,825...108,684,774
Ensembl chr 6:108,559,835...108,684,774
G
FPR2
formyl peptide receptor 2
increases expression
ISO
Diclofenac results in increased expression of FPR2 mRNA
CTD
PMID:26934552
NCBI chr19:51,761,180...51,770,531
Ensembl chr19:51,752,026...51,770,531
G
FRAT2
FRAT regulator of WNT signaling pathway 2
decreases expression
ISO
Diclofenac results in decreased expression of FRAT2 mRNA
CTD
PMID:35537566
NCBI chr10:97,332,497...97,334,729
Ensembl chr10:97,332,497...97,334,729
G
FRS2
fibroblast growth factor receptor substrate 2
affects expression
EXP
Diclofenac affects the expression of FRS2 mRNA
CTD
PMID:24752500
NCBI chr12:69,470,388...69,579,793
Ensembl chr12:69,470,349...69,579,793
G
FTCD
formimidoyltransferase cyclodeaminase
affects expression
EXP
Diclofenac affects the expression of FTCD mRNA
CTD
PMID:24752500
NCBI chr21:46,136,262...46,155,579
Ensembl chr21:46,136,160...46,155,579
G
FYB1
FYN binding protein 1
increases expression
ISO
Diclofenac results in increased expression of FYB1 mRNA
CTD
PMID:26934552
NCBI chr 5:39,105,252...39,274,528
Ensembl chr 5:39,105,252...39,274,528
G
FZD3
frizzled class receptor 3
affects expression
EXP
Diclofenac affects the expression of FZD3 mRNA
CTD
PMID:24752500
NCBI chr 8:28,494,212...28,574,258
Ensembl chr 8:28,494,205...28,574,267
G
FZD4
frizzled class receptor 4
affects expression
EXP
Diclofenac affects the expression of FZD4 mRNA
CTD
PMID:24752500
NCBI chr11:86,945,679...86,955,395
Ensembl chr11:86,945,679...86,955,395
G
FZD5
frizzled class receptor 5
affects expression
EXP
Diclofenac affects the expression of FZD5 mRNA
CTD
PMID:24752500
NCBI chr 2:207,762,598...207,769,906
Ensembl chr 2:207,762,598...207,769,906
G
FZD6
frizzled class receptor 6
affects expression
EXP
Diclofenac affects the expression of FZD6 mRNA
CTD
PMID:24752500
NCBI chr 8:103,298,494...103,332,866
Ensembl chr 8:103,298,433...103,332,866
G
FZD7
frizzled class receptor 7
affects expression
EXP
Diclofenac affects the expression of FZD7 mRNA
CTD
PMID:24752500
NCBI chr 2:202,033,855...202,038,441
Ensembl chr 2:202,033,855...202,038,441
G
GAB1
GRB2 associated binding protein 1
affects expression
EXP
Diclofenac affects the expression of GAB1 mRNA
CTD
PMID:24752500
NCBI chr 4:143,336,876...143,474,565
Ensembl chr 4:143,336,876...143,474,565
G
GAB2
GRB2 associated binding protein 2
affects expression
EXP
Diclofenac affects the expression of GAB2 mRNA
CTD
PMID:24752500
NCBI chr11:78,215,293...78,417,820
Ensembl chr11:78,215,293...78,418,348
G
GABRA5
gamma-aminobutyric acid type A receptor subunit alpha5
decreases expression
ISO
Diclofenac results in decreased expression of GABRA5 mRNA
CTD
PMID:26934552
NCBI chr15:26,866,719...26,949,208
Ensembl chr15:26,866,911...26,949,208
G
GADD45A
growth arrest and DNA damage inducible alpha
increases expression decreases expression affects expression
EXP ISO
Diclofenac results in increased expression of GADD45A mRNA Diclofenac results in decreased expression of GADD45A mRNA Diclofenac affects the expression of GADD45A mRNA
CTD
PMID:18172885 PMID:19022234 PMID:24752500 PMID:26934552 PMID:35537566
NCBI chr 1:67,685,201...67,688,334
Ensembl chr 1:67,685,201...67,688,334
G
GADD45G
growth arrest and DNA damage inducible gamma
increases expression
ISO
Diclofenac results in increased expression of GADD45G mRNA
CTD
PMID:26934552
NCBI chr 9:89,605,012...89,606,555
Ensembl chr 9:89,605,012...89,606,555
G
GALNT3
polypeptide N-acetylgalactosaminyltransferase 3
increases expression
ISO
Diclofenac results in increased expression of GALNT3 mRNA
CTD
PMID:30723492
NCBI chr 2:165,747,588...165,794,692
Ensembl chr 2:165,747,588...165,846,201
G
GARS1
glycyl-tRNA synthetase 1
affects expression decreases expression
EXP ISO
Diclofenac affects the expression of GARS1 mRNA Diclofenac results in decreased expression of GARS1 mRNA
CTD
PMID:24752500 PMID:35537566
NCBI chr 7:30,594,735...30,634,033
Ensembl chr 7:30,580,533...30,634,033
G
GART
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
affects expression
EXP
Diclofenac affects the expression of GART mRNA
CTD
PMID:24752500
NCBI chr21:33,503,931...33,542,893
Ensembl chr21:33,503,931...33,543,491
G
GAS1
growth arrest specific 1
decreases expression
ISO
Diclofenac results in decreased expression of GAS1 mRNA
CTD
PMID:26934552
NCBI chr 9:86,944,362...86,947,506
Ensembl chr 9:86,944,362...86,947,506
G
GATA4
GATA binding protein 4
affects expression
EXP
Diclofenac affects the expression of GATA4 mRNA
CTD
PMID:24752500
NCBI chr 8:11,676,935...11,760,002
Ensembl chr 8:11,676,959...11,760,002
G
GATA6
GATA binding protein 6
increases expression
ISO
Diclofenac results in increased expression of GATA6 mRNA
CTD
PMID:26934552
NCBI chr18:22,169,589...22,202,528
Ensembl chr18:22,169,589...22,202,528
G
GBP1
guanylate binding protein 1
decreases expression
EXP
Diclofenac results in decreased expression of GBP1 mRNA
CTD
PMID:19192274
NCBI chr 1:89,052,319...89,065,208
Ensembl chr 1:89,051,882...89,065,360
G
GBP4
guanylate binding protein 4
increases expression
ISO
Diclofenac results in increased expression of GBP3 mRNA
CTD
PMID:26934552
NCBI chr 1:89,181,144...89,198,942
Ensembl chr 1:89,181,144...89,198,942
G
GC
GC vitamin D binding protein
multiple interactions
ISO
[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of GC protein
CTD
PMID:25772430
NCBI chr 4:71,741,693...71,805,520
Ensembl chr 4:71,741,696...71,804,041
G
GCK
glucokinase
affects expression
ISO
Diclofenac affects the expression of GCK mRNA
CTD
PMID:26934552
NCBI chr 7:44,143,213...44,189,439
Ensembl chr 7:44,143,213...44,198,170
G
GCLC
glutamate-cysteine ligase catalytic subunit
decreases expression affects expression affects response to substance
ISO EXP
Diclofenac results in decreased expression of GCLC mRNA Diclofenac affects the expression of GCLC mRNA GCLC protein affects the susceptibility to Diclofenac
CTD
PMID:17202759 PMID:19481141 PMID:24752500
NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970
G
GCLM
glutamate-cysteine ligase modifier subunit
affects expression
EXP
Diclofenac affects the expression of GCLM mRNA
CTD
PMID:24752500
NCBI chr 1:93,885,199...93,909,430
Ensembl chr 1:93,885,199...93,909,456
G
GDF15
growth differentiation factor 15
increases expression
ISO EXP
Diclofenac results in increased expression of GDF15 mRNA Diclofenac results in increased expression of GDF15 protein
CTD
PMID:15555568 PMID:18076062
NCBI chr19:18,386,158...18,389,176
Ensembl chr19:18,374,731...18,389,176
G
GDF6
growth differentiation factor 6
increases expression
ISO
Diclofenac results in increased expression of GDF6 mRNA
CTD
PMID:30723492
NCBI chr 8:96,142,333...96,160,806
Ensembl chr 8:96,142,333...96,160,806
G
GFPT1
glutamine--fructose-6-phosphate transaminase 1
increases expression
ISO
Diclofenac results in increased expression of GFPT1 mRNA
CTD
PMID:26934552
NCBI chr 2:69,319,780...69,387,227
Ensembl chr 2:69,319,780...69,387,250
G
GGT1
gamma-glutamyltransferase 1
multiple interactions
ISO
[lipopolysaccharide, E coli O55-B5 co-treated with Diclofenac] results in increased activity of GGT1 protein
CTD
PMID:23939143
NCBI chr22:24,583,750...24,628,996
Ensembl chr22:24,594,811...24,629,005
G
GHR
growth hormone receptor
affects expression
ISO
Diclofenac affects the expression of GHR protein
CTD
PMID:26934552
NCBI chr 5:42,423,439...42,721,878
Ensembl chr 5:42,423,439...42,721,878
G
GIT2
GIT ArfGAP 2
affects expression
EXP
Diclofenac affects the expression of GIT2 mRNA
CTD
PMID:24752500
NCBI chr12:109,929,804...110,000,164
Ensembl chr12:109,929,804...109,996,389
G
GJA1
gap junction protein alpha 1
increases expression
ISO
Diclofenac results in increased expression of GJA1 mRNA
CTD
PMID:26934552 PMID:35537566
NCBI chr 6:121,435,646...121,449,727
Ensembl chr 6:121,435,595...121,449,727
G
GJA3
gap junction protein alpha 3
increases expression
ISO
Diclofenac results in increased expression of GJA3 mRNA
CTD
PMID:26934552
NCBI chr13:20,138,255...20,161,565
Ensembl chr13:20,138,255...20,161,052
G
GLDC
glycine decarboxylase
affects expression
EXP
Diclofenac affects the expression of GLDC mRNA
CTD
PMID:24752500
NCBI chr 9:6,532,467...6,645,729
Ensembl chr 9:6,532,467...6,645,729
G
GLYCTK
glycerate kinase
affects expression
EXP
Diclofenac affects the expression of GLYCTK mRNA
CTD
PMID:24752500
NCBI chr 3:52,287,828...52,295,257
Ensembl chr 3:52,287,089...52,295,257
G
GNA13
G protein subunit alpha 13
affects expression
EXP
Diclofenac affects the expression of GNA13 mRNA
CTD
PMID:24752500
NCBI chr17:65,009,289...65,056,740
Ensembl chr17:65,009,289...65,056,740
G
GNAQ
G protein subunit alpha q
affects expression
EXP
Diclofenac affects the expression of GNAQ mRNA
CTD
PMID:24752500
NCBI chr 9:77,716,097...78,031,811
Ensembl chr 9:77,716,097...78,031,811
G
GNAS
GNAS complex locus
affects expression
EXP
Diclofenac affects the expression of GNAS mRNA
CTD
PMID:24752500
NCBI chr20:58,839,748...58,911,192
Ensembl chr20:58,839,718...58,911,192
G
GNAT1
G protein subunit alpha transducin 1
increases expression
ISO
Diclofenac results in increased expression of GNAT1 mRNA
CTD
PMID:26934552
NCBI chr 3:50,191,610...50,197,696
Ensembl chr 3:50,191,610...50,197,696
G
GNB5
G protein subunit beta 5
affects expression
EXP
Diclofenac affects the expression of GNB5 mRNA
CTD
PMID:24752500
NCBI chr15:52,115,100...52,191,392
Ensembl chr15:52,115,100...52,191,392
G
GNG4
G protein subunit gamma 4
affects expression
EXP
Diclofenac affects the expression of GNG4 mRNA
CTD
PMID:24752500
NCBI chr 1:235,547,685...235,650,608
Ensembl chr 1:235,547,685...235,650,754
G
GOT1
glutamic-oxaloacetic transaminase 1
affects expression increases secretion
EXP
Diclofenac affects the expression of GOT1 mRNA Diclofenac results in increased secretion of GOT1 protein
CTD
PMID:24752500 PMID:36442613
NCBI chr10:99,396,870...99,430,624
Ensembl chr10:99,396,870...99,430,624
G
GPD1
glycerol-3-phosphate dehydrogenase 1
multiple interactions
ISO
Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of GPD1 protein]
CTD
PMID:25772430
NCBI chr12:50,104,008...50,111,313
Ensembl chr12:50,103,982...50,111,313
G
GPLD1
glycosylphosphatidylinositol specific phospholipase D1
affects expression
EXP
Diclofenac affects the expression of GPLD1 mRNA
CTD
PMID:24752500
NCBI chr 6:24,423,969...24,495,287
Ensembl chr 6:24,424,565...24,495,205
G
GPR176
G protein-coupled receptor 176
decreases expression
ISO
Diclofenac results in decreased expression of GPR176 mRNA
CTD
PMID:35537566
NCBI chr15:39,799,008...39,920,266
Ensembl chr15:39,799,008...39,920,936
G
GPR20
G protein-coupled receptor 20
decreases expression
ISO
Diclofenac results in decreased expression of GPR20 mRNA
CTD
PMID:30723492
NCBI chr 8:141,356,470...141,367,286
Ensembl chr 8:141,356,470...141,367,286
G
GPT
glutamic--pyruvic transaminase
multiple interactions increases secretion increases expression increases activity
ISO EXP
[lipopolysaccharide, E coli O55-B5 co-treated with Diclofenac] results in increased activity of GPT protein; Diclofenac promotes the reaction [endotoxin, Escherichia coli results in increased activity of GPT protein]; Heparin inhibits the reaction [Diclofenac promotes the reaction [endotoxin, Escherichia coli results in increased activity of GPT protein]] Diclofenac results in increased secretion of GPT protein Diclofenac results in increased expression of GPT protein Diclofenac results in increased activity of GPT protein eritoran inhibits the reaction [Diclofenac results in increased expression of GPT protein]
CTD
PMID:23939143 PMID:24747151 PMID:26934552 PMID:27671914 PMID:30925002 PMID:31813902 PMID:36442613 More...
NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174
G
GPT2
glutamic--pyruvic transaminase 2
decreases expression
ISO
Diclofenac results in decreased expression of GPT2 mRNA
CTD
PMID:35537566
NCBI chr16:46,884,362...46,931,289
Ensembl chr16:46,884,362...46,931,289
G
GPX1
glutathione peroxidase 1
increases expression
ISO EXP
Diclofenac results in increased expression of GPX1 mRNA; Diclofenac results in increased expression of GPX1 protein
CTD
PMID:25772430 PMID:29027214
NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,174...49,358,605
G
GPX2
glutathione peroxidase 2
affects expression
EXP
Diclofenac affects the expression of GPX2 mRNA
CTD
PMID:24752500
NCBI chr14:64,939,158...64,942,745
Ensembl chr14:64,939,152...64,942,746
G
GRB10
growth factor receptor bound protein 10
affects expression
EXP
Diclofenac affects the expression of GRB10 mRNA
CTD
PMID:24752500
NCBI chr 7:50,590,068...50,793,453
Ensembl chr 7:50,590,063...50,793,462
G
GRM7
glutamate metabotropic receptor 7
increases expression
ISO
Diclofenac results in increased expression of GRM7 mRNA
CTD
PMID:26934552
NCBI chr 3:6,861,115...7,741,533
Ensembl chr 3:6,770,001...7,741,533
G
GSK3B
glycogen synthase kinase 3 beta
affects expression
EXP
Diclofenac affects the expression of GSK3B mRNA
CTD
PMID:24752500
NCBI chr 3:119,821,321...120,094,447
Ensembl chr 3:119,821,321...120,094,994
G
GSN
gelsolin
decreases expression
ISO
Diclofenac results in decreased expression of GSN mRNA
CTD
PMID:26934552
NCBI chr 9:121,201,483...121,332,842
Ensembl chr 9:121,207,794...121,332,843
G
GSTA1
glutathione S-transferase alpha 1
decreases activity
EXP
Diclofenac results in decreased activity of GSTA1 protein
CTD
PMID:27183920
NCBI chr 6:52,791,371...52,803,816
Ensembl chr 6:52,791,371...52,803,860
G
GSTA3
glutathione S-transferase alpha 3
decreases activity
EXP
Diclofenac results in decreased activity of GSTA3 protein
CTD
PMID:27183920
NCBI chr 6:52,896,646...52,909,698
Ensembl chr 6:52,896,639...52,909,698
G
GSTA4
glutathione S-transferase alpha 4
decreases activity
EXP
Diclofenac results in decreased activity of GSTA4 protein
CTD
PMID:27183920
NCBI chr 6:52,977,953...52,995,284
Ensembl chr 6:52,977,948...52,995,304
G
GSTA5
glutathione S-transferase alpha 5
increases expression multiple interactions
ISO
Diclofenac results in increased expression of GSTA5 protein [Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of GSTA5 protein
CTD
PMID:25772430
NCBI chr 6:52,831,692...52,846,245
Ensembl chr 6:52,831,655...52,840,843
G
GSTM1
glutathione S-transferase mu 1
decreases activity decreases expression
EXP ISO
Diclofenac results in decreased activity of GSTM1 protein Diclofenac results in decreased expression of GSTM1 mRNA
CTD
PMID:26934552 PMID:27183920
NCBI chr 1:109,687,817...109,693,745
Ensembl chr 1:109,687,814...109,709,039
G
GSTM2
glutathione S-transferase mu 2
decreases activity
EXP
Diclofenac results in decreased activity of GSTM2 protein
CTD
PMID:27183920
NCBI chr 1:109,668,057...109,683,997
Ensembl chr 1:109,668,022...109,709,551
G
GSTM3
glutathione S-transferase mu 3
increases expression
ISO
Diclofenac results in increased expression of GSTM3 mRNA
CTD
PMID:26934552
NCBI chr 1:109,733,937...109,741,038
Ensembl chr 1:109,733,932...109,741,038
G
GSTM4
glutathione S-transferase mu 4
affects activity
EXP
Diclofenac affects the activity of GSTM4 protein
CTD
PMID:27183920
NCBI chr 1:109,656,099...109,667,727
Ensembl chr 1:109,656,099...109,665,496
G
GSTP1
glutathione S-transferase pi 1
multiple interactions affects activity affects metabolic processing
EXP
[[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 5-hydroxydiclofenac; [CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac; [CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased metabolism of Diclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of Diclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac Diclofenac affects the activity of GSTP1 protein GSTP1 protein affects the metabolism of Diclofenac metabolite; GSTP1 protein polymorphism affects the metabolism of Diclofenac metabolite
CTD
PMID:24185126 PMID:24246759 PMID:27183920
NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656
G
GSTT1
glutathione S-transferase theta 1
affects expression affects activity
EXP
Diclofenac affects the expression of GSTT1 mRNA Diclofenac affects the activity of GSTT1 protein
CTD
PMID:24752500 PMID:27183920
G
GSTT3P
glutathione S-transferase theta 3, pseudogene
decreases expression
ISO
Diclofenac results in decreased expression of GSTT3 mRNA
CTD
PMID:26934552
G
GTF2H4
general transcription factor IIH subunit 4
affects expression
EXP
Diclofenac affects the expression of GTF2H4 mRNA
CTD
PMID:24752500
NCBI chr 6:30,908,207...30,914,106
Ensembl chr 6:30,908,207...30,914,106
G
GTF2H5
general transcription factor IIH subunit 5
affects expression
EXP
Diclofenac affects the expression of GTF2H5 mRNA
CTD
PMID:24752500
NCBI chr 6:158,168,350...158,199,344
Ensembl chr 6:158,168,350...158,199,344
G
GTPBP2
GTP binding protein 2
decreases expression
ISO
Diclofenac results in decreased expression of GTPBP2 mRNA
CTD
PMID:35537566
NCBI chr 6:43,620,494...43,631,333
Ensembl chr 6:43,605,316...43,629,264
G
H2AX
H2A.X variant histone
increases expression
EXP
Diclofenac results in increased expression of H2AX protein
CTD
PMID:32087850
NCBI chr11:119,093,874...119,095,465
Ensembl chr11:119,093,874...119,095,465
G
H2BC11
H2B clustered histone 11
decreases expression
ISO
Diclofenac results in decreased expression of H2BC21 mRNA
CTD
PMID:26934552
NCBI chr 6:27,132,316...27,132,795
Ensembl chr 6:27,125,897...27,132,795
G
HAMP
hepcidin antimicrobial peptide
affects expression decreases secretion
ISO
Diclofenac affects the expression of HAMP mRNA Diclofenac results in decreased secretion of HAMP protein
CTD
PMID:24038040 PMID:26934552
NCBI chr19:35,282,528...35,285,143
Ensembl chr19:35,280,716...35,285,143
G
HAT1
histone acetyltransferase 1
affects expression
EXP
Diclofenac affects the expression of HAT1 mRNA
CTD
PMID:24752500
NCBI chr 2:171,922,461...171,983,686
Ensembl chr 2:171,922,448...171,983,686
G
HAVCR1
hepatitis A virus cellular receptor 1
increases expression
EXP
Diclofenac results in increased expression of HAVCR1 mRNA
CTD
PMID:23506792
NCBI chr 5:157,029,413...157,069,407
Ensembl chr 5:157,026,742...157,069,396
G
HBA1
hemoglobin subunit alpha 1
increases expression
ISO
Diclofenac results in increased expression of HBA-A2 protein
CTD
PMID:14565772
NCBI chr16:176,680...177,522
Ensembl chr16:176,680...177,522
G
HBB
hemoglobin subunit beta
increases expression
ISO
Diclofenac results in increased expression of HBB protein
CTD
PMID:14565772
NCBI chr11:5,225,464...5,227,071
Ensembl chr11:5,225,464...5,229,395
G
HBEGF
heparin binding EGF like growth factor
affects expression decreases expression increases expression
EXP ISO
Diclofenac affects the expression of HBEGF mRNA Diclofenac results in decreased expression of HBEGF mRNA Diclofenac results in increased expression of HBEGF mRNA
CTD
PMID:24752500 PMID:26934552 PMID:35537566
NCBI chr 5:140,332,843...140,346,603
Ensembl chr 5:140,332,843...140,346,603
G
HCK
HCK proto-oncogene, Src family tyrosine kinase
increases expression
ISO
Diclofenac results in increased expression of HCK mRNA
CTD
PMID:26934552
NCBI chr20:32,052,242...32,101,856
Ensembl chr20:32,052,197...32,101,856
G
HERC5
HECT and RLD domain containing E3 ubiquitin protein ligase 5
decreases expression
EXP
Diclofenac results in decreased expression of HERC5 mRNA
CTD
PMID:19192274
NCBI chr 4:88,457,119...88,506,163
Ensembl chr 4:88,457,119...88,506,163
G
HERC6
HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
decreases expression increases expression
EXP ISO
Diclofenac results in decreased expression of HERC6 mRNA Diclofenac results in increased expression of HERC6 mRNA
CTD
PMID:19192274 PMID:26934552
NCBI chr 4:88,378,852...88,443,097
Ensembl chr 4:88,378,739...88,443,097
G
HERPUD1
homocysteine inducible ER protein with ubiquitin like domain 1
affects expression decreases expression
EXP ISO
Diclofenac affects the expression of HERPUD1 mRNA Diclofenac results in decreased expression of HERPUD1 mRNA
CTD
PMID:24752500 PMID:26934552 PMID:35537566
NCBI chr16:56,932,142...56,944,864
Ensembl chr16:56,932,142...56,944,864
G
HES6
hes family bHLH transcription factor 6
decreases expression
ISO
Diclofenac results in decreased expression of HES6 mRNA
CTD
PMID:26934552
NCBI chr 2:238,238,267...238,240,038
Ensembl chr 2:238,238,267...238,240,662
G
HHEX
hematopoietically expressed homeobox
decreases expression
ISO
Diclofenac results in decreased expression of HHEX mRNA
CTD
PMID:26934552
NCBI chr10:92,689,955...92,695,647
Ensembl chr10:92,689,955...92,695,647
G
HIF1A
hypoxia inducible factor 1 subunit alpha
decreases expression
EXP
Diclofenac results in decreased expression of HIF1A protein
CTD
PMID:12912967
NCBI chr14:61,695,513...61,748,258
Ensembl chr14:61,695,513...61,748,259
G
HK1
hexokinase 1
increases expression
ISO
Diclofenac results in increased expression of HK1 mRNA
CTD
PMID:26934552
NCBI chr10:69,270,000...69,401,882
Ensembl chr10:69,269,984...69,401,884
G
HLA-DQB1
major histocompatibility complex, class II, DQ beta 1
decreases expression
ISO
Diclofenac results in decreased expression of RT1-BB mRNA
CTD
PMID:17202759
NCBI chr 6:32,659,467...32,666,657
Ensembl chr 6:32,659,467...32,668,383
G
HLA-DRB1
major histocompatibility complex, class II, DR beta 1
affects expression
EXP
Diclofenac affects the expression of HLA-DRB1 mRNA
CTD
PMID:25811541
NCBI chr 6:32,578,775...32,589,848
Ensembl chr 6:32,577,902...32,589,848
G
HMGB1
high mobility group box 1
multiple interactions increases expression affects expression
ISO EXP
Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HMGB1 protein] Diclofenac results in increased expression of HMGB1 mRNA; Diclofenac results in increased expression of HMGB1 protein Diclofenac affects the expression of HMGB1 mRNA
CTD
PMID:23939143 PMID:24747151 PMID:24752500 PMID:26934552
NCBI chr13:30,456,704...30,617,597
Ensembl chr13:30,456,704...30,617,597
G
HMGCS2
3-hydroxy-3-methylglutaryl-CoA synthase 2
decreases expression
ISO
Diclofenac results in decreased expression of HMGCS2 mRNA
CTD
PMID:26934552
NCBI chr 1:119,747,996...119,768,932
Ensembl chr 1:119,748,002...119,768,905
G
HMOX1
heme oxygenase 1
multiple interactions increases expression affects expression
EXP ISO
1-aminobenzotriazole inhibits the reaction [[Diclofenac co-treated with Buthionine Sulfoximine] results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [Diclofenac results in increased expression of HMOX1 mRNA] Diclofenac results in increased expression of HMOX1 mRNA; Diclofenac results in increased expression of HMOX1 protein Acetylcysteine inhibits the reaction [Diclofenac results in increased expression of HMOX1 protein]; Buthionine Sulfoximine promotes the reaction [Diclofenac results in increased expression of HMOX1 protein]; Diclofenac promotes the reaction [Buthionine Sulfoximine results in increased expression of HMOX1 protein] Acetylcysteine inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA]; Diclofenac promotes the reaction [Poly I-C results in increased expression of HMOX1 mRNA]; Ketoconazole inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA]; Sulfaphenazole inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA]; Tranylcypromine inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA] Diclofenac affects the expression of HMOX1 protein
CTD
PMID:12763371 PMID:18172885 PMID:18227147 PMID:19022234 PMID:19952508 PMID:23939143 PMID:27313093 PMID:29027214 More...
NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
G
HMX3
H6 family homeobox 3
decreases expression
ISO
Diclofenac results in decreased expression of HMX3 mRNA
CTD
PMID:35537566
NCBI chr10:123,135,970...123,139,423
Ensembl chr10:123,135,970...123,139,423
G
HNF1A
HNF1 homeobox A
affects expression
EXP
Diclofenac affects the expression of HNF1A mRNA
CTD
PMID:24752500
NCBI chr12:120,978,543...121,002,512
Ensembl chr12:120,978,543...121,002,512
G
HNF4A
hepatocyte nuclear factor 4 alpha
decreases expression
ISO
Diclofenac results in decreased expression of HNF4A mRNA
CTD
PMID:19022234
NCBI chr20:44,355,699...44,434,596
Ensembl chr20:44,355,699...44,432,845
G
HNRNPD
heterogeneous nuclear ribonucleoprotein D
affects expression
EXP
Diclofenac affects the expression of HNRNPD mRNA
CTD
PMID:24752500
NCBI chr 4:82,352,498...82,373,991
Ensembl chr 4:82,352,498...82,374,503
G
HP
haptoglobin
increases expression decreases expression
ISO
Diclofenac results in increased expression of HP mRNA Diclofenac results in decreased expression of HP mRNA
CTD
PMID:26934552
NCBI chr16:72,054,505...72,061,055
Ensembl chr16:72,054,505...72,061,055
G
HPGD
15-hydroxyprostaglandin dehydrogenase
increases activity multiple interactions increases expression
EXP
Diclofenac results in increased activity of HPGD protein [Diclofenac co-treated with NAD] binds to HPGD protein Diclofenac results in increased expression of HPGD mRNA
CTD
PMID:19501039 PMID:25526675
NCBI chr 4:174,490,175...174,522,893
Ensembl chr 4:174,490,175...174,523,154
G
HRAS
HRas proto-oncogene, GTPase
affects expression
EXP
Diclofenac affects the expression of HRAS mRNA
CTD
PMID:24752500
NCBI chr11:532,242...535,576
Ensembl chr11:532,242...537,321
G
HS3ST3B1
heparan sulfate-glucosamine 3-sulfotransferase 3B1
decreases expression
ISO
Diclofenac results in decreased expression of HS3ST3B1 mRNA
CTD
PMID:35537566
NCBI chr17:14,301,081...14,349,404
Ensembl chr17:14,301,081...14,349,404
G
HS6ST2
heparan sulfate 6-O-sulfotransferase 2
increases expression
ISO
Diclofenac results in increased expression of HS6ST2 mRNA
CTD
PMID:26934552
NCBI chr X:132,626,015...132,961,370
Ensembl chr X:132,626,015...132,961,395
G
HSF1
heat shock transcription factor 1
increases activity
EXP
Diclofenac results in increased activity of HSF1 protein
CTD
PMID:34170685
NCBI chr 8:144,291,604...144,314,720
Ensembl chr 8:144,291,591...144,314,720
G
HSP90AA1
heat shock protein 90 alpha family class A member 1
multiple interactions
ISO
Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HSP90AA1 mRNA]
CTD
PMID:23939143
NCBI chr14:102,080,742...102,139,749
Ensembl chr14:102,080,742...102,139,699
G
HSPA1A
heat shock protein family A (Hsp70) member 1A
multiple interactions affects expression increases expression
ISO
Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HSPA1A mRNA] Diclofenac affects the expression of HSPA1A mRNA Diclofenac results in increased expression of HSPA1A mRNA
CTD
PMID:19022234 PMID:23939143 PMID:25014874 PMID:26934552
NCBI chr 6:31,815,543...31,817,942
Ensembl chr 6:31,815,543...31,817,946
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HSPA1B
heat shock protein family A (Hsp70) member 1B
increases expression
ISO
Diclofenac results in increased expression of HSPA1B mRNA
CTD
PMID:26934552
NCBI chr 6:31,827,738...31,830,254
Ensembl chr 6:31,827,738...31,830,254
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HSPA5
heat shock protein family A (Hsp70) member 5
increases expression multiple interactions
ISO EXP
Diclofenac results in increased expression of HSPA5 mRNA [Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of HSPA5 protein
CTD
PMID:25014874 PMID:25772430 PMID:27313093
NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382
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HSPA8
heat shock protein family A (Hsp70) member 8
multiple interactions increases expression
ISO
Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HSPA8 mRNA] Diclofenac results in increased expression of HSPA8 mRNA
CTD
PMID:23939143 PMID:26934552
NCBI chr11:123,057,489...123,062,462
Ensembl chr11:123,057,489...123,063,230
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HSPB1
heat shock protein family B (small) member 1
decreases expression
ISO
Diclofenac results in decreased expression of HSPB1 mRNA
CTD
PMID:26934552
NCBI chr 7:76,302,673...76,304,292
Ensembl chr 7:76,302,673...76,304,295
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HSPB8
heat shock protein family B (small) member 8
increases expression
ISO
Diclofenac results in increased expression of HSPB8 mRNA
CTD
PMID:26934552
NCBI chr12:119,178,931...119,194,746
Ensembl chr12:119,171,555...119,224,855
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IARS1
isoleucyl-tRNA synthetase 1
decreases expression
ISO
Diclofenac results in decreased expression of IARS1 mRNA
CTD
PMID:35537566
NCBI chr 9:92,210,207...92,293,697
Ensembl chr 9:92,210,207...92,293,854
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IBTK
inhibitor of Bruton tyrosine kinase
increases expression
ISO
Diclofenac results in increased expression of IBTK mRNA
CTD
PMID:26934552
NCBI chr 6:82,169,987...82,247,744
Ensembl chr 6:82,169,986...82,247,754
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ICAM1
intercellular adhesion molecule 1
multiple interactions decreases expression affects expression increases expression
ISO EXP
Amlodipine inhibits the reaction [Diclofenac results in decreased expression of ICAM1 protein] Diclofenac affects the expression of ICAM1 mRNA Diclofenac results in decreased expression of ICAM1 mRNA Diclofenac results in increased expression of ICAM1 mRNA
CTD
PMID:14716214 PMID:18460984 PMID:24752500 PMID:26934552
NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615
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ID2
inhibitor of DNA binding 2
increases expression
ISO
Diclofenac results in increased expression of ID2 mRNA
CTD
PMID:26934552
NCBI chr 2:8,682,056...8,684,461
Ensembl chr 2:8,678,845...8,684,461
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ID3
inhibitor of DNA binding 3
increases expression
ISO
Diclofenac results in increased expression of ID3 mRNA
CTD
PMID:26934552
NCBI chr 1:23,557,926...23,559,501
Ensembl chr 1:23,557,926...23,559,501
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IDH2
isocitrate dehydrogenase (NADP(+)) 2
decreases expression
ISO
Diclofenac results in decreased expression of IDH2 mRNA
CTD
PMID:26934552
NCBI chr15:90,083,045...90,102,468
Ensembl chr15:90,083,045...90,102,477
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IER3
immediate early response 3
increases expression
ISO
Diclofenac results in increased expression of IER3 mRNA
CTD
PMID:26934552
NCBI chr 6:30,743,199...30,744,547
Ensembl chr 6:30,743,199...30,744,548
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IFI27
interferon alpha inducible protein 27
decreases expression
EXP
Diclofenac results in decreased expression of IFI27 mRNA
CTD
PMID:19192274
NCBI chr14:94,105,894...94,116,690
Ensembl chr14:94,104,836...94,116,695
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IFI35
interferon induced protein 35
decreases expression
EXP
Diclofenac results in decreased expression of IFI35 mRNA
CTD
PMID:19192274
NCBI chr17:43,006,784...43,014,456
Ensembl chr17:43,006,740...43,014,456
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IFI44
interferon induced protein 44
decreases expression
EXP ISO
Diclofenac results in decreased expression of IFI44 mRNA
CTD
PMID:19192274 PMID:35537566
NCBI chr 1:78,649,789...78,664,078
Ensembl chr 1:78,649,796...78,664,078
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IFI44L
interferon induced protein 44 like
decreases expression
EXP
Diclofenac results in decreased expression of IFI44L mRNA
CTD
PMID:19192274
NCBI chr 1:78,620,448...78,646,145
Ensembl chr 1:78,619,902...78,646,145
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IFI6
interferon alpha inducible protein 6
decreases expression
EXP
Diclofenac results in decreased expression of IFI6 mRNA
CTD
PMID:19192274
NCBI chr 1:27,666,064...27,672,192
Ensembl chr 1:27,666,064...27,672,212
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IFIH1
interferon induced with helicase C domain 1
decreases expression
EXP
Diclofenac results in decreased expression of IFIH1 mRNA
CTD
PMID:19192274
NCBI chr 2:162,267,074...162,318,684
Ensembl chr 2:162,267,074...162,318,684
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IFIT1
interferon induced protein with tetratricopeptide repeats 1
decreases expression
EXP
Diclofenac results in decreased expression of IFIT1 mRNA
CTD
PMID:19192274
NCBI chr10:89,392,623...89,406,487
Ensembl chr10:89,392,546...89,406,487
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IFIT3
interferon induced protein with tetratricopeptide repeats 3
decreases expression
EXP
Diclofenac results in decreased expression of IFIT3 mRNA
CTD
PMID:19192274
NCBI chr10:89,327,997...89,340,968
Ensembl chr10:89,327,307...89,377,473
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IFITM2
interferon induced transmembrane protein 2
increases expression
ISO
Diclofenac results in increased expression of IFITM2 mRNA
CTD
PMID:26934552
NCBI chr11:307,816...309,395
Ensembl chr11:303,655...309,397
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IFITM3
interferon induced transmembrane protein 3
increases expression
ISO
Diclofenac results in increased expression of IFITM3 mRNA
CTD
PMID:26934552
NCBI chr11:319,676...320,860
Ensembl chr11:319,676...329,475
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IFNA13
interferon alpha 13
increases expression
ISO
Diclofenac results in increased expression of IFNA9 mRNA
CTD
PMID:26934552
NCBI chr 9:21,367,372...21,368,057
Ensembl chr 9:21,367,372...21,368,057
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IFNG
interferon gamma
multiple interactions decreases expression
ISO EXP
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IFNG protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in decreased expression of NFKBIA protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IFNG mRNA]; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IFNG protein]; RELA mutant form inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; SN50 peptide inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]] 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [IFNG protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 2-aminoethoxydiphenyl borate inhibits the reaction [[Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein]; 2-aminoethoxydiphenyl borate inhibits the reaction [[TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; [Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein; [TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac affects the abundance of Calcium]; [TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac results in increased activity of CASP3 protein]; Calcium promotes the reaction [[Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein]; IFNG protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [[Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein] Diclofenac results in decreased expression of IFNG mRNA
CTD
PMID:19393675 PMID:22285467 PMID:23395999 PMID:23939143 PMID:26609140
NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
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IFRD1
interferon related developmental regulator 1
decreases expression
ISO
Diclofenac results in decreased expression of IFRD1 mRNA
CTD
PMID:35537566
NCBI chr 7:112,423,174...112,477,203
Ensembl chr 7:112,422,887...112,481,017
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IGF1R
insulin like growth factor 1 receptor
affects expression
EXP
Diclofenac affects the expression of IGF1R mRNA
CTD
PMID:24752500
NCBI chr15:98,648,539...98,964,530
Ensembl chr15:98,648,539...98,964,530
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IGFBP1
insulin like growth factor binding protein 1
affects expression increases expression
EXP ISO
Diclofenac affects the expression of IGFBP1 mRNA Diclofenac results in increased expression of IGFBP1 mRNA
CTD
PMID:24752500 PMID:26934552
NCBI chr 7:45,888,488...45,893,660
Ensembl chr 7:45,888,360...45,893,660
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IGFBP2
insulin like growth factor binding protein 2
decreases expression
ISO
Diclofenac results in decreased expression of IGFBP2 mRNA
CTD
PMID:26934552
NCBI chr 2:216,632,828...216,664,436
Ensembl chr 2:216,632,828...216,664,436
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IGFBP3
insulin like growth factor binding protein 3
affects expression
EXP
Diclofenac affects the expression of IGFBP3 mRNA
CTD
PMID:24752500
NCBI chr 7:45,912,245...45,921,272
Ensembl chr 7:45,912,245...45,921,874
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IKBKB
inhibitor of nuclear factor kappa B kinase subunit beta
multiple interactions
ISO
Diclofenac inhibits the reaction [Freund's Adjuvant results in increased phosphorylation of IKBKB protein]
CTD
PMID:25935278
NCBI chr 8:42,271,302...42,332,460
Ensembl chr 8:42,271,302...42,332,460
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IKBKE
inhibitor of nuclear factor kappa B kinase subunit epsilon
increases expression
ISO
Diclofenac results in increased expression of IKBKE mRNA
CTD
PMID:26934552
NCBI chr 1:206,470,476...206,496,889
Ensembl chr 1:206,470,476...206,496,889
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IKBKG
inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
affects expression
EXP
Diclofenac affects the expression of IKBKG mRNA
CTD
PMID:24752500
NCBI chr X:154,541,238...154,565,046
Ensembl chr X:154,541,199...154,565,046
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IL10
interleukin 10
increases response to substance multiple interactions
EXP ISO
IL10 gene polymorphism results in increased susceptibility to Diclofenac [Gum Arabic co-treated with Water deficiency co-treated with Diclofenac] results in increased expression of IL10 protein; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL10 protein]
CTD
PMID:15122773 PMID:23939143 PMID:31042592
NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
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IL12RB1
interleukin 12 receptor subunit beta 1
increases expression
ISO
Diclofenac results in increased expression of IL12RB1 mRNA
CTD
PMID:30723492
NCBI chr19:18,058,995...18,098,816
Ensembl chr19:18,058,995...18,098,944
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IL13RA1
interleukin 13 receptor subunit alpha 1
increases expression
ISO
Diclofenac results in increased expression of IL13RA1 mRNA
CTD
PMID:26934552
NCBI chr X:118,727,606...118,805,228
Ensembl chr X:118,727,133...118,794,535
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IL16
interleukin 16
decreases expression
ISO
Diclofenac results in decreased expression of IL16 mRNA
CTD
PMID:35537566
NCBI chr15:81,182,712...81,314,058
Ensembl chr15:81,159,575...81,314,058
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IL17A
interleukin 17A
increases expression multiple interactions
ISO
Diclofenac results in increased expression of IL17A protein Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of IL17A protein]
CTD
PMID:22285467 PMID:25450234
NCBI chr 6:52,186,375...52,190,638
Ensembl chr 6:52,186,375...52,190,638
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IL18BP
interleukin 18 binding protein
increases expression
ISO
Diclofenac results in increased expression of IL18BP mRNA
CTD
PMID:26934552
NCBI chr11:71,998,909...72,008,200
Ensembl chr11:71,998,613...72,007,315
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IL1A
interleukin 1 alpha
multiple interactions increases expression
EXP
[IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Diclofenac Diclofenac results in increased expression of IL1A mRNA
CTD
PMID:19362101 PMID:32816093
NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
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IL1B
interleukin 1 beta
multiple interactions increases expression
EXP ISO
Diclofenac inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein] Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of IL1B protein] Diclofenac results in increased expression of IL1B mRNA Diclofenac results in increased expression of IL1B mRNA; Diclofenac results in increased expression of IL1B protein 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; [Water deficiency co-treated with Diclofenac] results in increased expression of IL1B protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of IL1B protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in decreased expression of NFKBIA protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B mRNA]; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B protein]; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in increased expression of IL1B protein]; RELA mutant form inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; SN50 peptide inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]
CTD
PMID:15135310 PMID:15705740 PMID:19393675 PMID:22285467 PMID:23395999 PMID:23939143 PMID:24747151 PMID:25051504 PMID:25450234 PMID:25935278 PMID:28138970 PMID:29027214 PMID:31042592 PMID:31926916 PMID:32816093 More...
NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816
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IL1R1
interleukin 1 receptor type 1
affects expression increases expression
EXP ISO
Diclofenac affects the expression of IL1R1 mRNA Diclofenac results in increased expression of IL1R1 mRNA
CTD
PMID:24752500 PMID:26934552
NCBI chr 2:102,070,390...102,179,874
Ensembl chr 2:102,064,544...102,179,874
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IL1R2
interleukin 1 receptor type 2
increases expression
ISO
Diclofenac results in increased expression of IL1R2 mRNA
CTD
PMID:26934552 PMID:30723492
NCBI chr 2:101,991,960...102,028,544
Ensembl chr 2:101,991,960...102,028,544
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IL1RN
interleukin 1 receptor antagonist
increases secretion decreases expression increases expression multiple interactions
EXP ISO
Diclofenac results in increased secretion of IL1RN protein Diclofenac results in decreased expression of IL1RN mRNA Diclofenac results in increased expression of IL1RN mRNA Lipopolysaccharides inhibits the reaction [Diclofenac results in increased secretion of IL1RN protein]
CTD
PMID:9491209 PMID:26934552 PMID:35537566
NCBI chr 2:113,099,360...113,134,014
Ensembl chr 2:113,099,315...113,134,016
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IL2
interleukin 2
multiple interactions
EXP
Diclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL2 protein]
CTD
PMID:29777833
NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725
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IL23A
interleukin 23 subunit alpha
decreases expression
EXP
Diclofenac results in decreased expression of IL23A mRNA
CTD
PMID:19192274
NCBI chr12:56,338,884...56,340,410
Ensembl chr12:56,334,174...56,340,410
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IL24
interleukin 24
increases expression
EXP
Diclofenac results in increased expression of IL24 mRNA
CTD
PMID:32816093
NCBI chr 1:206,897,443...206,904,139
Ensembl chr 1:206,897,443...206,904,139
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IL2RG
interleukin 2 receptor subunit gamma
increases expression
ISO
Diclofenac results in increased expression of IL2RG mRNA
CTD
PMID:26934552
NCBI chr X:71,107,404...71,111,577
Ensembl chr X:71,107,404...71,112,108
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IL33
interleukin 33
decreases expression increases expression
ISO
Diclofenac results in decreased expression of IL33 mRNA Diclofenac results in increased expression of IL33 mRNA
CTD
PMID:26934552
NCBI chr 9:6,215,149...6,257,983
Ensembl chr 9:6,215,786...6,257,983
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IL4
interleukin 4
increases response to substance
EXP
IL4 gene polymorphism results in increased susceptibility to Diclofenac
CTD
PMID:15122773
NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678
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IL5
interleukin 5
multiple interactions
EXP
Diclofenac inhibits the reaction [nickel sulfate results in increased secretion of IL5 protein]
CTD
PMID:15663561
NCBI chr 5:132,541,445...132,556,815
Ensembl chr 5:132,541,445...132,556,838
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IL6
interleukin 6
multiple interactions increases expression decreases expression
EXP ISO
[IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Diclofenac; Diclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL6 protein]; Diclofenac inhibits the reaction [Mustard Gas results in increased secretion of IL6 protein]; lipopolysaccharide, Escherichia coli O111 B4 inhibits the reaction [Diclofenac results in increased expression of IL6 protein] Diclofenac results in increased expression of IL6 mRNA Diclofenac results in decreased expression of IL6 mRNA; Diclofenac results in decreased expression of IL6 protein Diclofenac results in increased expression of IL6 mRNA; Diclofenac results in increased expression of IL6 protein Diclofenac inhibits the reaction [Carrageenan results in increased expression of IL6 protein]; Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of IL6 protein]; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 protein]
CTD
PMID:19192274 PMID:19362101 PMID:23506792 PMID:23939143 PMID:24412305 PMID:25450234 PMID:25935278 PMID:27671914 PMID:29777833 PMID:31048000 More...
NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002
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IMMT
inner membrane mitochondrial protein
affects expression
ISO
Diclofenac affects the expression of IMMT mRNA
CTD
PMID:26934552
NCBI chr 2:86,143,936...86,195,462
Ensembl chr 2:86,143,932...86,195,472
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INHBB
inhibin subunit beta B
increases expression
ISO
Diclofenac results in increased expression of INHBB mRNA
CTD
PMID:26934552 PMID:30723492
NCBI chr 2:120,346,136...120,351,803
Ensembl chr 2:120,346,136...120,351,803
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INKA2
inka box actin regulator 2
increases expression
ISO
Diclofenac results in increased expression of FAM212B mRNA
CTD
PMID:35537566
NCBI chr 1:111,722,064...111,755,797
Ensembl chr 1:111,680,630...111,755,824
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INMT
indolethylamine N-methyltransferase
decreases expression
ISO
Diclofenac results in decreased expression of INMT mRNA
CTD
PMID:26934552
NCBI chr 7:30,752,135...30,757,602
Ensembl chr 7:30,697,985...30,757,602
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INSR
insulin receptor
affects expression
EXP
Diclofenac affects the expression of INSR mRNA
CTD
PMID:24752500
NCBI chr19:7,112,265...7,294,414
Ensembl chr19:7,112,255...7,294,414
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IRAK4
interleukin 1 receptor associated kinase 4
increases expression
ISO
Diclofenac results in increased expression of IRAK4 mRNA
CTD
PMID:26934552
NCBI chr12:43,758,951...43,789,541
Ensembl chr12:43,758,944...43,798,307
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IRF7
interferon regulatory factor 7
decreases expression
EXP
Diclofenac results in decreased expression of IRF7 mRNA
CTD
PMID:19192274
NCBI chr11:612,555...615,950
Ensembl chr11:612,553...615,983
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IRGM
immunity related GTPase M
increases expression
ISO
Diclofenac results in increased expression of IRGM1 mRNA
CTD
PMID:26934552
NCBI chr 5:150,846,521...150,902,402
Ensembl chr 5:150,846,521...150,900,736
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IRS1
insulin receptor substrate 1
affects expression
EXP ISO
Diclofenac affects the expression of IRS1 mRNA
CTD
PMID:24752500 PMID:26934552
NCBI chr 2:226,731,312...226,799,820
Ensembl chr 2:226,731,312...226,799,820
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ISG15
ISG15 ubiquitin like modifier
decreases expression
EXP
Diclofenac results in decreased expression of ISG15 mRNA
CTD
PMID:19192274
NCBI chr 1:1,013,497...1,014,540
Ensembl chr 1:1,001,138...1,014,540
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ISG20
interferon stimulated exonuclease gene 20
decreases expression
EXP
Diclofenac results in decreased expression of ISG20 mRNA
CTD
PMID:19192274
NCBI chr15:88,635,632...88,656,483
Ensembl chr15:88,635,670...88,656,483
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ISYNA1
inositol-3-phosphate synthase 1
increases expression
ISO
Diclofenac results in increased expression of ISYNA1 mRNA
CTD
PMID:26934552
NCBI chr19:18,434,388...18,438,133
Ensembl chr19:18,434,388...18,438,167
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ITGA2
integrin subunit alpha 2
affects expression
EXP
Diclofenac affects the expression of ITGA2 mRNA
CTD
PMID:24752500
NCBI chr 5:52,989,352...53,094,779
Ensembl chr 5:52,989,340...53,094,779
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ITGAL
integrin subunit alpha L
increases expression
ISO
Diclofenac results in increased expression of ITGAL mRNA
CTD
PMID:26934552
NCBI chr16:30,472,742...30,523,185
Ensembl chr16:30,472,658...30,523,567
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ITGAM
integrin subunit alpha M
increases expression
ISO
Diclofenac results in increased expression of ITGAM mRNA
CTD
PMID:27671914
NCBI chr16:31,259,975...31,332,877
Ensembl chr16:31,259,967...31,332,892
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ITGAX
integrin subunit alpha X
decreases expression
ISO
Diclofenac results in decreased expression of ITGAX mRNA
CTD
PMID:35537566
NCBI chr16:31,355,176...31,382,999
Ensembl chr16:31,355,134...31,382,999
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ITGB1
integrin subunit beta 1
affects expression
EXP
Diclofenac affects the expression of ITGB1 mRNA
CTD
PMID:24752500
NCBI chr10:32,900,318...32,958,230
Ensembl chr10:32,887,273...33,005,792
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ITGB2
integrin subunit beta 2
increases expression
ISO
Diclofenac results in increased expression of ITGB2 mRNA
CTD
PMID:26934552
NCBI chr21:44,885,953...44,928,815
Ensembl chr21:44,885,953...44,931,989
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ITGB3
integrin subunit beta 3
multiple interactions
EXP
Diclofenac inhibits the reaction [TNF protein results in increased expression of ITGB3 protein]
CTD
PMID:19691487
NCBI chr17:47,253,827...47,313,743
Ensembl chr17:47,253,827...47,313,743
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ITIH3
inter-alpha-trypsin inhibitor heavy chain 3
increases expression
ISO
Diclofenac results in increased expression of ITIH3 mRNA
CTD
PMID:26934552
NCBI chr 3:52,794,796...52,808,797
Ensembl chr 3:52,794,768...52,808,799
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ITIH4
inter-alpha-trypsin inhibitor heavy chain 4
increases expression
ISO
Diclofenac results in increased expression of ITIH4 mRNA
CTD
PMID:26934552
NCBI chr 3:52,812,962...52,830,672
Ensembl chr 3:52,812,962...52,830,688
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ITM2A
integral membrane protein 2A
increases expression
EXP
Diclofenac results in increased expression of ITM2A mRNA
CTD
PMID:17379860
NCBI chr X:79,360,384...79,367,334
Ensembl chr X:79,360,384...79,367,667
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JDP2
Jun dimerization protein 2
decreases expression
ISO
Diclofenac results in decreased expression of JDP2 mRNA
CTD
PMID:35537566
NCBI chr14:75,426,943...75,474,107
Ensembl chr14:75,427,716...75,474,111
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JUN
Jun proto-oncogene, AP-1 transcription factor subunit
affects expression increases expression
EXP ISO
Diclofenac affects the expression of JUN mRNA Diclofenac results in increased expression of JUN mRNA
CTD
PMID:24752500 PMID:26934552
NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048
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JUND
JunD proto-oncogene, AP-1 transcription factor subunit
increases expression
EXP ISO
Diclofenac results in increased expression of JUND mRNA
CTD
PMID:19022234
NCBI chr19:18,279,694...18,281,622
Ensembl chr19:18,279,694...18,281,622
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KAT6B
lysine acetyltransferase 6B
affects expression
EXP
Diclofenac affects the expression of KAT6B mRNA
CTD
PMID:24752500
NCBI chr10:74,824,936...75,032,624
Ensembl chr10:74,824,927...75,032,624
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KBTBD11
kelch repeat and BTB domain containing 11
increases expression
ISO
Diclofenac results in increased expression of KBTBD11 mRNA
CTD
PMID:30723492
NCBI chr 8:1,973,677...2,006,936
Ensembl chr 8:1,973,677...2,006,936
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KHDC3L
KH domain containing 3 like, subcortical maternal complex member
increases expression
ISO
Diclofenac results in increased expression of KHDC3 mRNA
CTD
PMID:30723492
NCBI chr 6:73,362,658...73,364,171
Ensembl chr 6:73,362,658...73,364,171
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KIF5C
kinesin family member 5C
increases expression
ISO
Diclofenac results in increased expression of KIF5C mRNA
CTD
PMID:30723492
NCBI chr 2:148,875,227...149,026,759
Ensembl chr 2:148,875,227...149,026,759
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KLF4
KLF transcription factor 4
decreases expression
ISO
Diclofenac results in decreased expression of KLF4 mRNA
CTD
PMID:35537566
NCBI chr 9:107,484,852...107,489,769
Ensembl chr 9:107,484,852...107,490,482
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KLHL33
kelch like family member 33
decreases expression
ISO
Diclofenac results in decreased expression of KLHL33 mRNA
CTD
PMID:35537566
NCBI chr14:20,425,852...20,436,166
Ensembl chr14:20,425,852...20,436,166
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KLK1
kallikrein 1
increases expression
ISO
Diclofenac results in increased expression of KLK1 protein
CTD
PMID:23506792
NCBI chr19:50,819,146...50,823,787
Ensembl chr19:50,819,146...50,823,787
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KNDC1
kinase non-catalytic C-lobe domain containing 1
increases expression
ISO
Diclofenac results in increased expression of KNDC1 mRNA
CTD
PMID:30723492
NCBI chr10:133,160,219...133,226,412
Ensembl chr10:133,160,219...133,226,412
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KNG1
kininogen 1
multiple interactions increases expression
ISO
[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of KNG1 protein; lipopolysaccharide, E coli O55-B5 promotes the reaction [Diclofenac results in increased expression of KNG1 protein]
CTD
PMID:25772430
NCBI chr 3:186,717,359...186,744,410
Ensembl chr 3:186,717,348...186,744,410
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KRAS
KRAS proto-oncogene, GTPase
affects expression
EXP
Diclofenac affects the expression of KRAS mRNA
CTD
PMID:24752500
NCBI chr12:25,205,246...25,250,929
Ensembl chr12:25,205,246...25,250,936
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LAX1
lymphocyte transmembrane adaptor 1
decreases expression
ISO
Diclofenac results in decreased expression of LAX1 mRNA
CTD
PMID:26934552
NCBI chr 1:203,765,183...203,776,372
Ensembl chr 1:203,765,177...203,776,372
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LBP
lipopolysaccharide binding protein
increases expression affects expression decreases expression
ISO
Diclofenac results in increased expression of LBP protein Diclofenac affects the expression of LBP mRNA Diclofenac results in decreased expression of LBP mRNA
CTD
PMID:26934552
NCBI chr20:38,346,482...38,377,013
Ensembl chr20:38,346,482...38,377,013
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LCE1D
late cornified envelope 1D
decreases expression
ISO
Diclofenac results in decreased expression of LCE1D mRNA
CTD
PMID:26934552
NCBI chr 1:152,796,721...152,798,181
Ensembl chr 1:152,796,721...152,798,181
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LCN2
lipocalin 2
increases expression multiple interactions
ISO
Diclofenac results in increased expression of LCN2 mRNA Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of LCN2 protein]; Diclofenac promotes the reaction [Buthionine Sulfoximine results in increased expression of LCN2 mRNA]
CTD
PMID:23939143 PMID:26934552
NCBI chr 9:128,149,453...128,153,453
Ensembl chr 9:128,149,071...128,153,453
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LCP2
lymphocyte cytosolic protein 2
increases expression
ISO
Diclofenac results in increased expression of LCP2 mRNA
CTD
PMID:26934552
NCBI chr 5:170,246,233...170,297,777
Ensembl chr 5:170,246,233...170,297,815
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LDHA
lactate dehydrogenase A
increases expression
ISO
Diclofenac results in increased expression of LDHA protein
CTD
PMID:25772430
NCBI chr11:18,394,563...18,408,425
Ensembl chr11:18,394,560...18,408,425
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LEAP2
liver enriched antimicrobial peptide 2
increases expression
ISO
Diclofenac results in increased expression of LEAP2 mRNA
CTD
PMID:26934552
NCBI chr 5:132,873,668...132,875,046
Ensembl chr 5:132,873,444...132,875,046
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LEPR
leptin receptor
affects expression increases expression
ISO
Diclofenac affects the expression of LEPR mRNA Diclofenac results in increased expression of LEPR protein
CTD
PMID:26934552
NCBI chr 1:65,420,652...65,641,559
Ensembl chr 1:65,420,652...65,641,559
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LGALS3
galectin 3
increases expression
ISO
Diclofenac results in increased expression of LGALS3 mRNA
CTD
PMID:26934552
NCBI chr14:55,129,252...55,145,430
Ensembl chr14:55,124,110...55,145,423
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LGMN
legumain
increases expression
ISO
Diclofenac results in increased expression of LGMN mRNA
CTD
PMID:26934552
NCBI chr14:92,703,809...92,748,627
Ensembl chr14:92,703,807...92,748,679
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LGR4
leucine rich repeat containing G protein-coupled receptor 4
increases expression
ISO
Diclofenac results in increased expression of LGR4 mRNA
CTD
PMID:35537566
NCBI chr11:27,365,961...27,472,790
Ensembl chr11:27,365,961...27,472,790
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LHX2
LIM homeobox 2
decreases expression
ISO
Diclofenac results in decreased expression of LHX2 mRNA
CTD
PMID:35537566
NCBI chr 9:124,011,768...124,033,301
Ensembl chr 9:124,001,670...124,033,301
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LIFR
LIF receptor subunit alpha
decreases expression
ISO
Diclofenac results in decreased expression of LIFR mRNA
CTD
PMID:26934552
NCBI chr 5:38,474,668...38,608,403
Ensembl chr 5:38,474,668...38,608,354
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LILRB3
leukocyte immunoglobulin like receptor B3
increases expression
ISO
Diclofenac results in increased expression of PIRB mRNA
CTD
PMID:26934552 PMID:30723492
NCBI chr19:54,216,278...54,223,007
Ensembl chr19:54,216,278...54,223,506
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LIPC
lipase C, hepatic type
decreases expression
ISO
Diclofenac results in decreased expression of LIPC mRNA
CTD
PMID:26934552
NCBI chr15:58,431,991...58,569,844
Ensembl chr15:58,410,569...58,569,844
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LITAF
lipopolysaccharide induced TNF factor
increases expression
ISO
Diclofenac results in increased expression of LITAF mRNA
CTD
PMID:26934552
NCBI chr16:11,547,722...11,640,317
Ensembl chr16:11,547,722...11,636,381
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LMNB1
lamin B1
increases expression
ISO
Diclofenac results in increased expression of LMNB1 mRNA
CTD
PMID:35537566
NCBI chr 5:126,776,623...126,837,020
Ensembl chr 5:126,776,623...126,837,020
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LMO4
LIM domain only 4
decreases expression
ISO
Diclofenac results in decreased expression of LMO4 mRNA
CTD
PMID:35537566
NCBI chr 1:87,328,880...87,348,923
Ensembl chr 1:87,328,880...87,348,923
G
LPAR4
lysophosphatidic acid receptor 4
decreases expression
ISO
Diclofenac results in decreased expression of LPAR4 mRNA
CTD
PMID:26934552
NCBI chr X:78,747,720...78,758,714
Ensembl chr X:78,747,709...78,758,714
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LPL
lipoprotein lipase
increases expression
ISO
Diclofenac results in increased expression of LPL mRNA
CTD
PMID:26934552
NCBI chr 8:19,939,253...19,967,259
Ensembl chr 8:19,901,717...19,967,259
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LRG1
leucine rich alpha-2-glycoprotein 1
increases expression
ISO
Diclofenac results in increased expression of LRG1 mRNA
CTD
PMID:26934552
NCBI chr19:4,536,402...4,540,036
Ensembl chr19:4,536,402...4,540,036
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LRP8
LDL receptor related protein 8
increases expression
ISO
Diclofenac results in increased expression of LRP8 mRNA
CTD
PMID:35537566
NCBI chr 1:53,242,364...53,328,070
Ensembl chr 1:53,242,364...53,328,469
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LTC4S
leukotriene C4 synthase
increases expression
ISO
Diclofenac results in increased expression of LTC4S mRNA
CTD
PMID:30723492
NCBI chr 5:179,793,986...179,796,647
Ensembl chr 5:179,793,980...179,796,647
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LXN
latexin
increases expression
EXP
Diclofenac results in increased expression of LXN mRNA
CTD
PMID:19192274
NCBI chr 3:158,666,414...158,672,648
Ensembl chr 3:158,645,822...158,672,648
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LY6E
lymphocyte antigen 6 family member E
decreases expression increases expression
EXP ISO
Diclofenac results in decreased expression of LY6E mRNA Diclofenac results in increased expression of LY6E mRNA
CTD
PMID:19192274 PMID:26934552
NCBI chr 8:143,018,529...143,022,409
Ensembl chr 8:143,017,982...143,023,832
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LY75
lymphocyte antigen 75
increases expression
ISO
Diclofenac results in increased expression of LY75 mRNA
CTD
PMID:26934552
NCBI chr 2:159,803,355...159,904,756
Ensembl chr 2:159,803,355...159,904,756
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LYZ
lysozyme
increases expression
ISO
Diclofenac results in increased expression of LYZ2 mRNA
CTD
PMID:26934552
NCBI chr12:69,348,381...69,354,234
Ensembl chr12:69,348,381...69,354,234
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MAGI1
membrane associated guanylate kinase, WW and PDZ domain containing 1
affects expression
EXP
Diclofenac affects the expression of MAGI1 mRNA
CTD
PMID:24752500
NCBI chr 3:65,353,526...66,038,918
Ensembl chr 3:65,353,525...66,038,918
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MAOA
monoamine oxidase A
affects expression
EXP
Diclofenac affects the expression of MAOA mRNA
CTD
PMID:24752500
NCBI chr X:43,655,006...43,746,817
Ensembl chr X:43,654,907...43,746,817
G
MAOB
monoamine oxidase B
affects expression
EXP
Diclofenac affects the expression of MAOB mRNA
CTD
PMID:24752500
NCBI chr X:43,766,610...43,882,450
Ensembl chr X:43,766,610...43,882,450
G
MAP2K3
mitogen-activated protein kinase kinase 3
affects expression
EXP
Diclofenac affects the expression of MAP2K3 mRNA
CTD
PMID:24752500
NCBI chr17:21,284,711...21,315,240
Ensembl chr17:21,284,672...21,315,232
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MAP2K5
mitogen-activated protein kinase kinase 5
affects expression
EXP
Diclofenac affects the expression of MAP2K5 mRNA
CTD
PMID:24752500
NCBI chr15:67,542,703...67,807,114
Ensembl chr15:67,542,703...67,807,117
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MAP2K6
mitogen-activated protein kinase kinase 6
affects expression
EXP
Diclofenac affects the expression of MAP2K6 mRNA
CTD
PMID:24752500
NCBI chr17:69,414,697...69,553,865
Ensembl chr17:69,414,697...69,553,865
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MAP3K1
mitogen-activated protein kinase kinase kinase 1
increases expression
ISO
Diclofenac results in increased expression of MAP3K1 mRNA
CTD
PMID:26934552
NCBI chr 5:56,815,549...56,896,152
Ensembl chr 5:56,815,549...56,896,152
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MAP3K12
mitogen-activated protein kinase kinase kinase 12
decreases expression
ISO
Diclofenac results in decreased expression of MAP3K12 mRNA
CTD
PMID:18172885
NCBI chr12:53,479,669...53,501,539
Ensembl chr12:53,479,669...53,500,063
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MAP3K7
mitogen-activated protein kinase kinase kinase 7
affects expression
EXP
Diclofenac affects the expression of MAP3K7 mRNA
CTD
PMID:24752500
NCBI chr 6:90,513,579...90,587,072
Ensembl chr 6:90,513,573...90,587,086
G
MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
affects expression
EXP
Diclofenac affects the expression of MAP4K4 mRNA
CTD
PMID:24752500
NCBI chr 2:101,697,707...101,894,690
Ensembl chr 2:101,696,850...101,894,690
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MAP7D1
MAP7 domain containing 1
increases expression
ISO
Diclofenac results in increased expression of MAP7D1 mRNA
CTD
PMID:26934552
NCBI chr 1:36,156,160...36,180,849
Ensembl chr 1:36,155,579...36,180,849
G
MAPK1
mitogen-activated protein kinase 1
multiple interactions increases phosphorylation
EXP
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Diclofenac results in increased phosphorylation of MAPK1 protein]; 2-aminoethoxydiphenyl borate inhibits the reaction [Diclofenac results in increased phosphorylation of MAPK1 protein]; Calcium promotes the reaction [Diclofenac results in increased phosphorylation of MAPK1 protein]; pyrazolanthrone inhibits the reaction [Diclofenac results in increased phosphorylation of MAPK1 protein] Diclofenac analog results in increased phosphorylation of MAPK1 protein; Diclofenac results in increased phosphorylation of MAPK1 protein
CTD
PMID:24104198 PMID:26609140
NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
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MAPK13
mitogen-activated protein kinase 13
affects expression
EXP
Diclofenac affects the expression of MAPK13 mRNA
CTD
PMID:24752500
NCBI chr 6:36,130,513...36,144,521
Ensembl chr 6:36,127,809...36,144,524
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MAPK14
mitogen-activated protein kinase 14
affects expression
EXP
Diclofenac affects the expression of MAPK14 mRNA
CTD
PMID:24752500
NCBI chr 6:36,027,808...36,124,214
Ensembl chr 6:36,027,782...36,111,236
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MAPK3
mitogen-activated protein kinase 3
multiple interactions increases phosphorylation
EXP
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Diclofenac results in increased phosphorylation of MAPK3 protein]; 2-aminoethoxydiphenyl borate inhibits the reaction [Diclofenac results in increased phosphorylation of MAPK3 protein]; Calcium promotes the reaction [Diclofenac results in increased phosphorylation of MAPK3 protein]; pyrazolanthrone inhibits the reaction [Diclofenac results in increased phosphorylation of MAPK3 protein] Diclofenac analog results in increased phosphorylation of MAPK3 protein; Diclofenac results in increased phosphorylation of MAPK3 protein
CTD
PMID:24104198 PMID:26609140
NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506
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MAPK8
mitogen-activated protein kinase 8
affects expression
EXP
Diclofenac affects the expression of MAPK8 mRNA
CTD
PMID:24752500
NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360
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MAPK8IP3
mitogen-activated protein kinase 8 interacting protein 3
increases expression
ISO
Diclofenac results in increased expression of MAPK8IP3 mRNA
CTD
PMID:26934552
NCBI chr16:1,706,195...1,770,351
Ensembl chr16:1,706,166...1,770,351
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MAPKAPK3
MAPK activated protein kinase 3
increases expression
ISO
Diclofenac results in increased expression of MAPKAPK3 mRNA
CTD
PMID:26934552
NCBI chr 3:50,611,520...50,649,291
Ensembl chr 3:50,611,520...50,649,291
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MARCHF1
membrane associated ring-CH-type finger 1
increases expression
ISO
Diclofenac results in increased expression of MARCHF1 mRNA
CTD
PMID:26934552 PMID:35537566
NCBI chr 4:163,524,298...164,384,019
Ensembl chr 4:163,524,298...164,384,050
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MARCO
macrophage receptor with collagenous structure
increases expression decreases expression
ISO
Diclofenac results in increased expression of MARCO mRNA Diclofenac results in decreased expression of MARCO mRNA
CTD
PMID:26934552
NCBI chr 2:118,942,194...118,994,660
Ensembl chr 2:118,942,194...118,994,660
G
MASTL
microtubule associated serine/threonine kinase like
decreases expression
ISO
Diclofenac results in decreased expression of MASTL mRNA
CTD
PMID:26934552 PMID:35537566
NCBI chr10:27,154,479...27,187,953
Ensembl chr10:27,154,824...27,187,953
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MBL1P
mannose binding lectin 1, pseudogene
increases expression
ISO
Diclofenac results in increased expression of MBL1 mRNA
CTD
PMID:26934552
NCBI chr10:79,920,178...79,923,119
Ensembl chr10:79,920,327...79,923,032 Ensembl chr10:79,920,327...79,923,032
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MCAM
melanoma cell adhesion molecule
decreases expression
ISO
Diclofenac results in decreased expression of MCAM mRNA
CTD
PMID:35537566
NCBI chr11:119,308,529...119,317,130
Ensembl chr11:119,308,529...119,321,521
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MCM7
minichromosome maintenance complex component 7
affects expression
EXP
Diclofenac affects the expression of MCM7 mRNA
CTD
PMID:24752500
NCBI chr 7:100,092,728...100,101,397
Ensembl chr 7:100,092,233...100,101,940
G
MCTP1
multiple C2 and transmembrane domain containing 1
increases expression
ISO
Diclofenac results in increased expression of MCTP1 mRNA
CTD
PMID:30723492
NCBI chr 5:94,703,690...95,285,094
Ensembl chr 5:94,703,690...95,285,094
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MDM2
MDM2 proto-oncogene
decreases expression
ISO
Diclofenac results in decreased expression of MDM2 mRNA
CTD
PMID:17202759
NCBI chr12:68,808,172...68,850,686
Ensembl chr12:68,808,177...68,845,544
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MECOM
MDS1 and EVI1 complex locus
decreases expression
ISO
Diclofenac results in decreased expression of MECOM mRNA
CTD
PMID:26934552
NCBI chr 3:169,083,507...169,663,712
Ensembl chr 3:169,083,499...169,663,775
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MED10
mediator complex subunit 10
affects expression
EXP
Diclofenac affects the expression of MED10 mRNA
CTD
PMID:24752500
NCBI chr 5:6,371,874...6,378,547
Ensembl chr 5:6,371,874...6,378,571
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MED13
mediator complex subunit 13
affects expression
EXP
Diclofenac affects the expression of MED13 mRNA
CTD
PMID:24752500
NCBI chr17:61,942,605...62,065,278
Ensembl chr17:61,942,605...62,065,278
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MED13L
mediator complex subunit 13L
affects expression
EXP
Diclofenac affects the expression of MED13L mRNA
CTD
PMID:24752500
NCBI chr12:115,958,576...116,277,693
Ensembl chr12:115,957,905...116,277,693
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MED14
mediator complex subunit 14
affects expression
EXP
Diclofenac affects the expression of MED14 mRNA
CTD
PMID:24752500
NCBI chr X:40,648,305...40,736,159
Ensembl chr X:40,648,305...40,735,858
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MED17
mediator complex subunit 17
affects expression
EXP
Diclofenac affects the expression of MED17 mRNA
CTD
PMID:24752500
NCBI chr11:93,784,282...93,814,963
Ensembl chr11:93,784,227...93,814,963
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MED30
mediator complex subunit 30
affects expression
EXP
Diclofenac affects the expression of MED30 mRNA
CTD
PMID:24752500
NCBI chr 8:117,520,713...117,540,262
Ensembl chr 8:117,520,713...117,540,262
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MED31
mediator complex subunit 31
affects expression
EXP
Diclofenac affects the expression of MED31 mRNA
CTD
PMID:24752500
NCBI chr17:6,643,311...6,651,605
Ensembl chr17:6,643,311...6,651,634
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MED6
mediator complex subunit 6
affects expression
EXP
Diclofenac affects the expression of MED6 mRNA
CTD
PMID:24752500
NCBI chr14:70,583,221...70,600,655
Ensembl chr14:70,581,257...70,600,690
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MEF2A
myocyte enhancer factor 2A
affects expression
EXP
Diclofenac affects the expression of MEF2A mRNA
CTD
PMID:24752500
NCBI chr15:99,565,417...99,716,488
Ensembl chr15:99,565,417...99,716,488
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MET
MET proto-oncogene, receptor tyrosine kinase
decreases expression increases expression
EXP
Diclofenac results in decreased expression of MET mRNA Diclofenac results in increased expression of MET mRNA
CTD
PMID:19192274 PMID:32816093
NCBI chr 7:116,672,196...116,798,377
Ensembl chr 7:116,672,196...116,798,377
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MFN1
mitofusin 1
multiple interactions decreases expression
ISO
AICA ribonucleotide inhibits the reaction [Diclofenac results in decreased expression of MFN1 protein]
CTD
PMID:27792760
NCBI chr 3:179,347,709...179,394,936
Ensembl chr 3:179,347,709...179,394,936
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MFN2
mitofusin 2
multiple interactions decreases expression
ISO
AICA ribonucleotide inhibits the reaction [Diclofenac results in decreased expression of MFN2 protein]
CTD
PMID:27792760
NCBI chr 1:11,980,444...12,013,508
Ensembl chr 1:11,980,181...12,015,211
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MFSD2A
MFSD2 lysolipid transporter A, lysophospholipid
increases expression
ISO
Diclofenac results in increased expression of MFSD2A mRNA
CTD
PMID:35537566
NCBI chr 1:39,955,145...39,969,956
Ensembl chr 1:39,955,112...39,969,968
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MGLL
monoglyceride lipase
decreases expression
ISO
Diclofenac results in decreased expression of MGLL mRNA
CTD
PMID:26934552
NCBI chr 3:127,689,066...127,823,185
Ensembl chr 3:127,689,062...128,052,190
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MGMT
O-6-methylguanine-DNA methyltransferase
increases expression
ISO
Diclofenac results in increased expression of MGMT mRNA
CTD
PMID:35537566
NCBI chr10:129,467,241...129,770,983
Ensembl chr10:129,467,190...129,770,983
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MIR122
microRNA 122
increases expression
EXP ISO
Diclofenac results in increased expression of MIR122 Diclofenac results in increased expression of MIR122 mRNA
CTD
PMID:25527335 PMID:30925002
NCBI chr18:58,451,074...58,451,158
Ensembl chr18:58,451,074...58,451,158
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MIR192
microRNA 192
increases expression
ISO
Diclofenac results in increased expression of MIR192 mRNA
CTD
PMID:30925002
NCBI chr11:64,891,137...64,891,246
Ensembl chr11:64,891,137...64,891,246
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MIRLET7D
microRNA let-7d
decreases expression
ISO
Diclofenac results in decreased expression of MIRLET7D mRNA
CTD
PMID:30723492
NCBI chr 9:94,178,834...94,178,920
Ensembl chr 9:94,178,834...94,178,920
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MKNK2
MAPK interacting serine/threonine kinase 2
affects expression
EXP
Diclofenac affects the expression of MKNK2 mRNA
CTD
PMID:24752500
NCBI chr19:2,037,471...2,051,244
Ensembl chr19:2,037,465...2,051,244
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MKRN2
makorin ring finger protein 2
decreases expression
ISO
Diclofenac results in decreased expression of MKRN2 mRNA
CTD
PMID:35537566
NCBI chr 3:12,557,087...12,583,713
Ensembl chr 3:12,557,057...12,586,208
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MME
membrane metalloendopeptidase
decreases expression
ISO
Diclofenac results in decreased expression of MME mRNA
CTD
PMID:26934552
NCBI chr 3:155,024,202...155,183,729
Ensembl chr 3:155,024,124...155,183,704
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MMP12
matrix metallopeptidase 12
decreases expression
EXP
Diclofenac results in decreased expression of MMP12 mRNA
CTD
PMID:19192274
NCBI chr11:102,862,736...102,874,982
Ensembl chr11:102,862,736...102,874,982
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MMP16
matrix metallopeptidase 16
increases expression
ISO
Diclofenac results in increased expression of MMP16 mRNA
CTD
PMID:26934552
NCBI chr 8:88,032,011...88,327,483
Ensembl chr 8:88,032,011...88,328,025
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MMP8
matrix metallopeptidase 8
increases expression
ISO
Diclofenac results in increased expression of MMP8 mRNA
CTD
PMID:30723492
NCBI chr11:102,711,796...102,724,954
Ensembl chr11:102,711,796...102,727,050
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MNDA
myeloid cell nuclear differentiation antigen
increases expression
ISO
Diclofenac results in increased expression of MNDA mRNA
CTD
PMID:26934552
NCBI chr 1:158,831,351...158,849,502
Ensembl chr 1:158,831,351...158,849,506
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MPEG1
macrophage expressed 1
increases expression
ISO
Diclofenac results in increased expression of MPEG1 mRNA
CTD
PMID:26934552
NCBI chr11:59,208,510...59,212,927
Ensembl chr11:59,208,510...59,212,927
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MPO
myeloperoxidase
multiple interactions increases expression increases activity
ISO EXP
Diclofenac inhibits the reaction [Carrageenan results in increased activity of MPO protein]; sodium nitrate inhibits the reaction [Diclofenac results in increased activity of MPO protein] Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of MPO protein] Diclofenac results in increased expression of MPO mRNA [Hydrogen Peroxide results in increased activity of MPO protein] which results in increased oxidation of and results in increased susceptibility to Diclofenac
CTD
PMID:17275683 PMID:24412305 PMID:27671914 PMID:28754375 PMID:31926916
NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935
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MR1
major histocompatibility complex, class I-related
affects expression
EXP
Diclofenac affects the expression of MR1 mRNA
CTD
PMID:25811541
NCBI chr 1:181,033,387...181,061,938
Ensembl chr 1:181,033,374...181,061,938
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MRAS
muscle RAS oncogene homolog
affects expression
EXP
Diclofenac affects the expression of MRAS mRNA
CTD
PMID:24752500
NCBI chr 3:138,347,648...138,405,535
Ensembl chr 3:138,347,648...138,405,534
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MS4A14
membrane spanning 4-domains A14
increases expression
ISO
Diclofenac results in increased expression of MS4A14 mRNA
CTD
PMID:30723492
NCBI chr11:60,396,459...60,417,756
Ensembl chr11:60,378,530...60,417,756
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MT1X
metallothionein 1X
increases expression
ISO
Diclofenac results in increased expression of MT1 mRNA
CTD
PMID:26934552
NCBI chr16:56,682,470...56,684,196
Ensembl chr16:56,682,470...56,684,196
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MT2A
metallothionein 2A
increases expression
ISO
Diclofenac results in increased expression of MT2 mRNA
CTD
PMID:26934552
NCBI chr16:56,608,584...56,609,497
Ensembl chr16:56,608,584...56,609,497
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MTBP
MDM2 binding protein
decreases expression
ISO
Diclofenac results in decreased expression of MTBP mRNA
CTD
PMID:35537566
NCBI chr 8:120,445,419...120,523,636
Ensembl chr 8:120,445,400...120,542,133
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MTHFD2
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
affects expression decreases expression
EXP ISO
Diclofenac affects the expression of MTHFD2 mRNA Diclofenac results in decreased expression of MTHFD2 mRNA
CTD
PMID:24752500 PMID:35537566
NCBI chr 2:74,198,615...74,217,565
Ensembl chr 2:74,186,172...74,217,565
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MTHFD2L
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like
increases expression
ISO
Diclofenac results in increased expression of MTHFD2L mRNA
CTD
PMID:30723492
NCBI chr 4:74,114,560...74,303,099
Ensembl chr 4:74,114,174...74,303,099
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MTSS1
MTSS I-BAR domain containing 1
increases expression
ISO
Diclofenac results in increased expression of MTSS1 mRNA
CTD
PMID:26934552
NCBI chr 8:124,550,784...124,728,473
Ensembl chr 8:124,550,784...124,728,473
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MVP
major vault protein
increases expression
ISO
Diclofenac results in increased expression of MVP mRNA
CTD
PMID:26934552
NCBI chr16:29,820,394...29,848,039
Ensembl chr16:29,820,394...29,848,039
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MX1
MX dynamin like GTPase 1
decreases expression
EXP
Diclofenac results in decreased expression of MX1 mRNA
CTD
PMID:19192274
NCBI chr21:41,420,558...41,459,214
Ensembl chr21:41,420,020...41,470,071
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MXD1
MAX dimerization protein 1
affects expression
EXP
Diclofenac affects the expression of MXD1 mRNA
CTD
PMID:24752500
NCBI chr 2:69,915,109...69,942,945
Ensembl chr 2:69,897,688...69,942,945
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MYC
MYC proto-oncogene, bHLH transcription factor
increases expression decreases expression affects expression
ISO EXP
Diclofenac results in increased expression of MYC mRNA Diclofenac results in decreased expression of MYC mRNA Diclofenac affects the expression of MYC mRNA
CTD
PMID:19022234 PMID:24752500 PMID:35537566
NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951
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MYD88
MYD88 innate immune signal transduction adaptor
increases expression
ISO
Diclofenac results in increased expression of MYD88 mRNA
CTD
PMID:26934552
NCBI chr 3:38,138,661...38,143,022
Ensembl chr 3:38,138,552...38,143,024
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NAPEPLD
N-acyl phosphatidylethanolamine phospholipase D
affects expression
EXP
Diclofenac affects the expression of NAPEPLD mRNA
CTD
PMID:24752500
NCBI chr 7:103,099,776...103,150,001
Ensembl chr 7:103,099,776...103,149,560
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NARS1
asparaginyl-tRNA synthetase 1
decreases expression
ISO
Diclofenac results in decreased expression of NARS1 mRNA
CTD
PMID:35537566
NCBI chr18:57,600,656...57,621,836
Ensembl chr18:57,600,656...57,622,213
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NCF1
neutrophil cytosolic factor 1
increases expression
ISO
Diclofenac results in increased expression of NCF1 mRNA
CTD
PMID:26934552
NCBI chr 7:74,774,011...74,789,315
Ensembl chr 7:74,774,011...74,789,315
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NCF4
neutrophil cytosolic factor 4
increases expression
ISO
Diclofenac results in increased expression of NCF4 mRNA
CTD
PMID:26934552
NCBI chr22:36,861,006...36,878,015
Ensembl chr22:36,860,988...36,878,017
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NCOA3
nuclear receptor coactivator 3
affects expression
EXP
Diclofenac affects the expression of NCOA3 mRNA
CTD
PMID:24752500
NCBI chr20:47,501,887...47,656,872
Ensembl chr20:47,501,887...47,656,877
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NEDD4L
NEDD4 like E3 ubiquitin protein ligase
increases expression
ISO
Diclofenac results in increased expression of NEDD4L mRNA
CTD
PMID:26934552
NCBI chr18:58,044,226...58,401,540
Ensembl chr18:58,044,226...58,401,540
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NEK6
NIMA related kinase 6
increases expression
ISO
Diclofenac results in increased expression of NEK6 mRNA
CTD
PMID:26934552
NCBI chr 9:124,257,606...124,353,307
Ensembl chr 9:124,257,606...124,353,307
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NFE2L2
NFE2 like bZIP transcription factor 2
increases stability multiple interactions
EXP
Diclofenac results in increased stability of NFE2L2 protein NFE2L2 protein affects the reaction [Diclofenac results in increased expression of SRXN1 mRNA]
CTD
PMID:24752500
NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756
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NFIL3
nuclear factor, interleukin 3 regulated
increases expression decreases expression
ISO
Diclofenac results in increased expression of NFIL3 mRNA Diclofenac results in decreased expression of NFIL3 mRNA
CTD
PMID:26934552 PMID:35537566
NCBI chr 9:91,409,045...91,483,497
Ensembl chr 9:91,409,045...91,423,832
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NFKB1
nuclear factor kappa B subunit 1
multiple interactions decreases expression
EXP ISO
Diclofenac inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Diclofenac inhibits the reaction [TNF protein results in increased activity of NFKB1 protein] Diclofenac results in decreased expression of NFKB1 mRNA
CTD
PMID:15489888 PMID:29027214
NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302
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NFKBIA
NFKB inhibitor alpha
multiple interactions decreases expression
EXP ISO
Diclofenac inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein] Diclofenac inhibits the reaction [Freund's Adjuvant results in increased phosphorylation of NFKBIA protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in decreased expression of NFKBIA protein] Diclofenac results in decreased expression of NFKBIA mRNA
CTD
PMID:15489888 PMID:18172885 PMID:19393675 PMID:25935278
NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749
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NFKBIZ
NFKB inhibitor zeta
decreases expression increases expression
ISO
Diclofenac results in decreased expression of NFKBIZ mRNA Diclofenac results in increased expression of NFKBIZ mRNA
CTD
PMID:26934552
NCBI chr 3:101,827,990...101,861,022
Ensembl chr 3:101,827,991...101,861,022
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NHERF1
NHERF family PDZ scaffold protein 1
increases expression
ISO
Diclofenac results in increased expression of NHERF1 mRNA
CTD
PMID:26934552
NCBI chr17:74,748,628...74,769,353
Ensembl chr17:74,748,628...74,769,353
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NHERF2
NHERF family PDZ scaffold protein 2
decreases expression
ISO
Diclofenac results in decreased expression of NHERF2 mRNA
CTD
PMID:26934552
NCBI chr16:2,026,902...2,039,026
Ensembl chr16:2,025,356...2,039,026
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NHSL2
NHS like 2
increases expression
ISO
Diclofenac results in increased expression of NHSL2 mRNA
CTD
PMID:35537566
NCBI chr X:71,910,845...72,153,286
Ensembl chr X:71,910,845...72,161,750
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NIPAL1
NIPA like domain containing 1
increases expression
ISO
Diclofenac results in increased expression of NIPAL1 mRNA
CTD
PMID:26934552
NCBI chr 4:48,016,772...48,040,173
Ensembl chr 4:47,914,142...48,040,173
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NLRP1
NLR family pyrin domain containing 1
multiple interactions
ISO
Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of NLRP1A protein]
CTD
PMID:25450234
NCBI chr17:5,501,396...5,584,509
Ensembl chr17:5,499,415...5,619,424
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NLRP3
NLR family pyrin domain containing 3
increases expression
ISO EXP
Diclofenac results in increased expression of NLRP3 mRNA
CTD
PMID:24747151 PMID:28138970
NCBI chr 1:247,416,077...247,448,817
Ensembl chr 1:247,332,331...247,449,108
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NNMT
nicotinamide N-methyltransferase
increases expression
ISO
Diclofenac results in increased expression of NNMT mRNA
CTD
PMID:26934552
NCBI chr11:114,257,806...114,313,536
Ensembl chr11:114,257,787...114,313,536
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NOS2
nitric oxide synthase 2
increases expression decreases expression multiple interactions
ISO EXP
Diclofenac results in increased expression of NOS2 mRNA Diclofenac results in decreased expression of NOS2 mRNA 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 mRNA]; Diclofenac promotes the reaction [Poly I-C results in increased expression of NOS2 mRNA]; RELA mutant form inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; SN50 peptide inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; sodium nitrate inhibits the reaction [Diclofenac results in increased expression of NOS2 mRNA]
CTD
PMID:15135310 PMID:16944022 PMID:17275683 PMID:19393675 PMID:23395999 PMID:23939143 PMID:29027214 PMID:35537566 More...
NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
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NOVA1
NOVA alternative splicing regulator 1
decreases expression
ISO
Diclofenac results in decreased expression of NOVA1 mRNA
CTD
PMID:26934552
NCBI chr14:26,443,090...26,598,033
Ensembl chr14:26,443,090...26,598,033
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NOX1
NADPH oxidase 1
decreases expression
ISO
Diclofenac results in decreased expression of NOX1 mRNA
CTD
PMID:35537566
NCBI chr X:100,843,324...100,874,359
Ensembl chr X:100,843,324...100,874,359
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NQO1
NAD(P)H quinone dehydrogenase 1
increases activity multiple interactions affects expression increases expression
EXP ISO
Diclofenac results in increased activity of NQO1 protein Diclofenac inhibits the reaction [NQO1 protein results in increased reduction of 2,6-Dichloroindophenol] Diclofenac affects the expression of NQO1 mRNA Diclofenac results in increased expression of NQO1 mRNA
CTD
PMID:8572925 PMID:18172885 PMID:24752500 PMID:29281794
NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
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NR0B2
nuclear receptor subfamily 0 group B member 2
affects expression
EXP
Diclofenac affects the expression of NR0B2 mRNA
CTD
PMID:24752500
NCBI chr 1:26,911,489...26,913,975
Ensembl chr 1:26,911,489...26,913,975
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NR1D1
nuclear receptor subfamily 1 group D member 1
increases expression
ISO
Diclofenac results in increased expression of NR1D1 mRNA
CTD
PMID:35537566
NCBI chr17:40,092,793...40,100,589
Ensembl chr17:40,092,793...40,100,589
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NR1I2
nuclear receptor subfamily 1 group I member 2
increases expression increases activity
EXP
Diclofenac results in increased expression of NR1I2 mRNA Diclofenac results in increased activity of NR1I2 protein
CTD
PMID:19022234 PMID:28728110
NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,487
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NR1I3
nuclear receptor subfamily 1 group I member 3
affects expression
EXP
Diclofenac affects the expression of NR1I3 mRNA
CTD
PMID:19022234
NCBI chr 1:161,229,669...161,238,203
Ensembl chr 1:161,229,666...161,238,244
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NR2F1
nuclear receptor subfamily 2 group F member 1
affects expression
EXP
Diclofenac affects the expression of NR2F1 mRNA
CTD
PMID:24752500
NCBI chr 5:93,583,222...93,594,611
Ensembl chr 5:93,583,222...93,594,611
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NR2F2
nuclear receptor subfamily 2 group F member 2
affects expression
EXP
Diclofenac affects the expression of NR2F2 mRNA
CTD
PMID:24752500
NCBI chr15:96,326,046...96,340,263
Ensembl chr15:96,325,938...96,340,263
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NR2F6
nuclear receptor subfamily 2 group F member 6
affects expression
EXP
Diclofenac affects the expression of NR2F6 mRNA
CTD
PMID:24752500
NCBI chr19:17,231,883...17,245,919
Ensembl chr19:17,231,883...17,245,919
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NR3C1
nuclear receptor subfamily 3 group C member 1
affects expression multiple interactions
EXP
Diclofenac affects the expression of NR3C1 mRNA Diclofenac binds to and affects the activity of NR3C1 protein
CTD
PMID:24752500 PMID:29777833
NCBI chr 5:143,277,931...143,435,512
Ensembl chr 5:143,277,931...143,435,512
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NR6A1
nuclear receptor subfamily 6 group A member 1
affects expression
EXP
Diclofenac affects the expression of NR6A1 mRNA
CTD
PMID:24752500
NCBI chr 9:124,517,275...124,771,311
Ensembl chr 9:124,517,275...124,771,311
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NRAS
NRAS proto-oncogene, GTPase
affects expression
EXP
Diclofenac affects the expression of NRAS mRNA
CTD
PMID:24752500
NCBI chr 1:114,704,469...114,716,771
Ensembl chr 1:114,704,469...114,716,771
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NREP
neuronal regeneration related protein
decreases expression
ISO
Diclofenac results in decreased expression of NREP mRNA
CTD
PMID:26934552
NCBI chr 5:111,728,802...111,976,932
Ensembl chr 5:111,662,621...111,997,464
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NRG4
neuregulin 4
increases expression
ISO
Diclofenac results in increased expression of NRG4 mRNA
CTD
PMID:26934552
NCBI chr15:75,935,393...76,060,240
Ensembl chr15:75,935,969...76,059,795
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NRP1
neuropilin 1
increases expression
ISO
Diclofenac results in increased expression of NRP1 mRNA
CTD
PMID:26934552
NCBI chr10:33,177,493...33,334,667
Ensembl chr10:33,177,492...33,336,262
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NT5E
5'-nucleotidase ecto
increases expression
ISO
Diclofenac results in increased expression of NT5E mRNA
CTD
PMID:35537566
NCBI chr 6:85,450,083...85,495,784
Ensembl chr 6:85,449,584...85,495,791
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NUPR1
nuclear protein 1, transcriptional regulator
decreases expression
ISO
Diclofenac results in decreased expression of NUPR1 mRNA
CTD
PMID:35537566
NCBI chr16:28,532,708...28,538,974
Ensembl chr16:28,532,708...28,539,008
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NXPE4
neurexophilin and PC-esterase domain family member 4
increases expression
ISO
Diclofenac results in increased expression of NXPE4 mRNA
CTD
PMID:26934552
NCBI chr11:114,570,591...114,678,250
Ensembl chr11:114,570,591...114,595,786
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OAS1
2'-5'-oligoadenylate synthetase 1
decreases expression
EXP
Diclofenac results in decreased expression of OAS1 mRNA
CTD
PMID:19192274
NCBI chr12:112,906,962...112,933,219
Ensembl chr12:112,905,856...112,933,219
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OCLN
occludin
decreases expression
EXP ISO
Diclofenac results in decreased expression of OCLN mRNA
CTD
PMID:29027214
NCBI chr 5:69,492,547...69,558,104
Ensembl chr 5:69,492,292...69,558,104
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OLFML2B
olfactomedin like 2B
increases expression
EXP
Diclofenac results in increased expression of OLFML2B mRNA
CTD
PMID:19192274
NCBI chr 1:161,983,192...162,023,869
Ensembl chr 1:161,983,192...162,023,869
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OPA1
OPA1 mitochondrial dynamin like GTPase
decreases expression multiple interactions
ISO
Diclofenac results in decreased expression of OPA1 mRNA AICA ribonucleotide inhibits the reaction [Diclofenac results in decreased expression of OPA1 protein]
CTD
PMID:26934552 PMID:27792760
NCBI chr 3:193,593,208...193,697,811
Ensembl chr 3:193,593,144...193,697,811
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OPCML
opioid binding protein/cell adhesion molecule like
increases expression
ISO
Diclofenac results in increased expression of OPCML mRNA
CTD
PMID:26934552
NCBI chr11:132,414,981...133,532,501
Ensembl chr11:132,414,977...133,532,501
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OR8D1
olfactory receptor family 8 subfamily D member 1
decreases expression
ISO
Diclofenac results in decreased expression of OR8D1B mRNA
CTD
PMID:35537566
NCBI chr11:124,302,831...124,313,949
Ensembl chr11:124,302,831...124,315,099
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ORM1
orosomucoid 1
multiple interactions increases expression
ISO
[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of ORM1 protein Diclofenac results in increased expression of ORM1 mRNA
CTD
PMID:25772430 PMID:26934552
NCBI chr 9:114,323,098...114,326,479
Ensembl chr 9:114,323,098...114,326,479
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ORM2
orosomucoid 2
increases expression
ISO
Diclofenac results in increased expression of ORM2 mRNA
CTD
PMID:26934552
NCBI chr 9:114,329,869...114,333,251
Ensembl chr 9:114,329,869...114,333,251
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P2RX4
purinergic receptor P2X 4
multiple interactions
ISO
Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of P2RX4 protein]
CTD
PMID:25450234
NCBI chr12:121,210,129...121,234,106
Ensembl chr12:121,210,065...121,234,106
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P2RX5
purinergic receptor P2X 5
increases expression
ISO
Diclofenac results in increased expression of P2RX5 mRNA
CTD
PMID:30723492
NCBI chr17:3,673,227...3,696,155
Ensembl chr17:3,672,199...3,696,240
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P2RX7
purinergic receptor P2X 7
multiple interactions increases expression
ISO
Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of P2RX7 protein] Diclofenac results in increased expression of P2RX7 mRNA
CTD
PMID:25935278 PMID:26934552
NCBI chr12:121,132,876...121,188,032
Ensembl chr12:121,132,819...121,188,032
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P4HA2
prolyl 4-hydroxylase subunit alpha 2
increases expression
EXP
Diclofenac results in increased expression of P4HA2 mRNA
CTD
PMID:17379860
NCBI chr 5:132,190,147...132,227,853
Ensembl chr 5:132,190,147...132,295,315
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P4HB
prolyl 4-hydroxylase subunit beta
multiple interactions increases expression
ISO
[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of P4HB protein Diclofenac results in increased expression of P4HB protein
CTD
PMID:25772430
NCBI chr17:81,843,166...81,860,535
Ensembl chr17:81,843,159...81,860,856
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PAK2
p21 (RAC1) activated kinase 2
affects expression
EXP
Diclofenac affects the expression of PAK2 mRNA
CTD
PMID:24752500
NCBI chr 3:196,739,857...196,832,647
Ensembl chr 3:196,739,857...196,832,647
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PAQR8
progestin and adipoQ receptor family member 8
increases expression
ISO
Diclofenac results in increased expression of PAQR8 mRNA
CTD
PMID:30723492
NCBI chr 6:52,362,151...52,407,777
Ensembl chr 6:52,361,421...52,407,777
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PARP1
poly(ADP-ribose) polymerase 1
affects expression
EXP
Diclofenac affects the expression of PARP1 mRNA
CTD
PMID:24752500
NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154
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PAX6
paired box 6
increases expression
ISO
Diclofenac results in increased expression of PAX6 mRNA
CTD
PMID:26934552
NCBI chr11:31,789,026...31,817,961
Ensembl chr11:31,784,779...31,817,961
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PCDHGA8
protocadherin gamma subfamily A, 8
increases expression
ISO
Diclofenac results in increased expression of PCDHGA8 mRNA
CTD
PMID:30723492
NCBI chr 5:141,392,633...141,512,975
Ensembl chr 5:141,390,157...141,512,975
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PCK1
phosphoenolpyruvate carboxykinase 1
affects expression
EXP
Diclofenac affects the expression of PCK1 mRNA
CTD
PMID:24752500
NCBI chr20:57,561,110...57,568,121
Ensembl chr20:57,561,080...57,568,121
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PCK2
phosphoenolpyruvate carboxykinase 2, mitochondrial
decreases expression
ISO
Diclofenac results in decreased expression of PCK2 mRNA
CTD
PMID:35537566
NCBI chr14:24,094,171...24,104,125
Ensembl chr14:24,094,053...24,110,598
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PCNA
proliferating cell nuclear antigen
affects expression
EXP
Diclofenac affects the expression of PCNA protein
CTD
PMID:23506792
NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626
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PCSK9
proprotein convertase subtilisin/kexin type 9
increases expression
ISO
Diclofenac results in increased expression of PCSK9 mRNA
CTD
PMID:26934552
NCBI chr 1:55,039,548...55,064,852
Ensembl chr 1:55,039,445...55,064,852
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PDCD4
programmed cell death 4
decreases expression increases expression
EXP
Diclofenac results in decreased expression of PDCD4 mRNA Diclofenac results in increased expression of PDCD4 mRNA
CTD
PMID:21873647
NCBI chr10:110,871,928...110,900,006
Ensembl chr10:110,871,795...110,900,006
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PDE9A
phosphodiesterase 9A
increases expression
ISO
Diclofenac results in increased expression of PDE9A mRNA
CTD
PMID:30723492
NCBI chr21:42,653,621...42,775,509
Ensembl chr21:42,653,621...42,775,509
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PDGFRB
platelet derived growth factor receptor beta
decreases expression
ISO
Diclofenac results in decreased expression of PDGFRB mRNA
CTD
PMID:26934552
NCBI chr 5:150,113,839...150,155,845
Ensembl chr 5:150,113,839...150,155,872
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PDIA6
protein disulfide isomerase family A member 6
increases expression
ISO
Diclofenac results in increased expression of PDIA6 mRNA
CTD
PMID:26934552
NCBI chr 2:10,783,391...10,837,712
Ensembl chr 2:10,783,391...10,837,977
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PDILT
protein disulfide isomerase like, testis expressed
decreases expression
ISO
Diclofenac results in decreased expression of PDILT mRNA
CTD
PMID:26934552
NCBI chr16:20,359,175...20,404,737
Ensembl chr16:20,359,175...20,404,737
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PDK4
pyruvate dehydrogenase kinase 4
decreases expression
ISO
Diclofenac results in decreased expression of PDK4 mRNA
CTD
PMID:26934552
NCBI chr 7:95,583,499...95,596,516
Ensembl chr 7:95,583,499...95,596,516
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PDPK1
3-phosphoinositide dependent protein kinase 1
affects expression
EXP
Diclofenac affects the expression of PDPK1 mRNA
CTD
PMID:24752500
NCBI chr16:2,538,021...2,603,188
Ensembl chr16:2,537,979...2,603,188
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PHF10
PHD finger protein 10
decreases expression
ISO
Diclofenac results in decreased expression of PHF10 mRNA
CTD
PMID:35537566
NCBI chr 6:169,703,902...169,724,500
Ensembl chr 6:169,703,902...169,725,566
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PHLDA1
pleckstrin homology like domain family A member 1
decreases expression
ISO
Diclofenac results in decreased expression of PHLDA1 mRNA
CTD
PMID:26934552
NCBI chr12:76,025,447...76,031,776
Ensembl chr12:76,025,447...76,031,776
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PHLDA3
pleckstrin homology like domain family A member 3
increases expression
ISO
Diclofenac results in increased expression of PHLDA3 mRNA
CTD
PMID:35537566
NCBI chr 1:201,464,278...201,469,188
Ensembl chr 1:201,464,278...201,469,237
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PHYHIPL
phytanoyl-CoA 2-hydroxylase interacting protein like
decreases expression
ISO
Diclofenac results in decreased expression of PHYHIPL mRNA
CTD
PMID:26934552
NCBI chr10:59,173,597...59,247,770
Ensembl chr10:59,176,643...59,247,774
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PID1
phosphotyrosine interaction domain containing 1
increases expression
EXP
Diclofenac results in increased expression of PID1 mRNA
CTD
PMID:32816093
NCBI chr 2:229,023,973...229,271,287
Ensembl chr 2:228,850,526...229,271,287
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PIK3C2A
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
affects expression
EXP
Diclofenac affects the expression of PIK3C2A mRNA
CTD
PMID:24752500
NCBI chr11:17,086,575...17,207,986
Ensembl chr11:17,077,730...17,207,986
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PIK3CA
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
affects expression
EXP
Diclofenac affects the expression of PIK3CA mRNA
CTD
PMID:24752500
NCBI chr 3:179,148,126...179,240,093
Ensembl chr 3:179,148,114...179,240,093
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PIK3CD
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
affects expression
EXP
Diclofenac affects the expression of PIK3CD mRNA
CTD
PMID:24752500
NCBI chr 1:9,627,258...9,729,114
Ensembl chr 1:9,629,889...9,729,114
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PIK3R1
phosphoinositide-3-kinase regulatory subunit 1
affects expression increases expression
EXP ISO
Diclofenac affects the expression of PIK3R1 mRNA Diclofenac results in increased expression of PIK3R1 mRNA
CTD
PMID:24752500 PMID:26934552
NCBI chr 5:68,215,756...68,301,821
Ensembl chr 5:68,215,740...68,301,821
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PIK3R2
phosphoinositide-3-kinase regulatory subunit 2
affects expression
EXP
Diclofenac affects the expression of PIK3R2 mRNA
CTD
PMID:24752500
NCBI chr19:18,153,163...18,170,532
Ensembl chr19:18,153,163...18,170,532
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PIK3R3
phosphoinositide-3-kinase regulatory subunit 3
affects expression
EXP
Diclofenac affects the expression of PIK3R3 mRNA
CTD
PMID:24752500
NCBI chr 1:46,040,140...46,174,901
Ensembl chr 1:46,040,140...46,133,036
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PKLR
pyruvate kinase L/R
increases expression
ISO
Diclofenac results in increased expression of PKLR mRNA
CTD
PMID:26934552
NCBI chr 1:155,289,293...155,308,654
Ensembl chr 1:155,289,293...155,301,438
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PKNOX2
PBX/knotted 1 homeobox 2
increases expression
ISO
Diclofenac results in increased expression of PKNOX2 mRNA
CTD
PMID:30723492
NCBI chr11:125,164,751...125,433,389
Ensembl chr11:125,164,687...125,433,389
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PLA2G12A
phospholipase A2 group XIIA
affects expression
EXP
Diclofenac affects the expression of PLA2G12A mRNA
CTD
PMID:24752500
NCBI chr 4:109,709,989...109,730,070
Ensembl chr 4:109,709,989...109,730,070
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PLA2G4C
phospholipase A2 group IVC
increases expression
ISO
Diclofenac results in increased expression of PLA2G4C mRNA
CTD
PMID:26934552
NCBI chr19:48,047,846...48,110,817
Ensembl chr19:48,047,843...48,110,817
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PLA2G7
phospholipase A2 group VII
increases expression
ISO
Diclofenac results in increased expression of PLA2G7 mRNA
CTD
PMID:26934552
NCBI chr 6:46,704,201...46,735,721
Ensembl chr 6:46,704,201...46,735,693
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PLAC8
placenta associated 8
increases expression
ISO
Diclofenac results in increased expression of PLAC8 mRNA
CTD
PMID:26934552
NCBI chr 4:83,090,048...83,114,729
Ensembl chr 4:83,090,048...83,137,075
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PLAU
plasminogen activator, urokinase
increases expression decreases expression
ISO
Diclofenac results in increased expression of PLAU protein Diclofenac results in decreased expression of PLAU mRNA
CTD
PMID:23506792 PMID:35537566
NCBI chr10:73,909,164...73,917,494
Ensembl chr10:73,909,177...73,917,496
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PLCG1
phospholipase C gamma 1
affects expression
EXP
Diclofenac affects the expression of PLCG1 mRNA
CTD
PMID:24752500
NCBI chr20:41,137,543...41,177,626
Ensembl chr20:41,136,960...41,196,801
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PLD1
phospholipase D1
increases expression
ISO
Diclofenac results in increased expression of PLD1 mRNA
CTD
PMID:26934552
NCBI chr 3:171,600,404...171,810,483
Ensembl chr 3:171,600,404...171,810,950
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PLEKHH2
pleckstrin homology, MyTH4 and FERM domain containing H2
decreases expression
ISO
Diclofenac results in decreased expression of PLEKHH2 mRNA
CTD
PMID:35537566
NCBI chr 2:43,637,260...43,767,987
Ensembl chr 2:43,637,260...43,767,987
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PLK3
polo like kinase 3
affects expression
ISO
Diclofenac affects the expression of PLK3 mRNA
CTD
PMID:26934552
NCBI chr 1:44,800,377...44,805,990
Ensembl chr 1:44,800,377...44,805,990
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PLSCR1
phospholipid scramblase 1
increases expression
ISO
Diclofenac results in increased expression of PLSCR1 mRNA
CTD
PMID:26934552
NCBI chr 3:146,515,180...146,544,607
Ensembl chr 3:146,515,180...146,544,856
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PMAIP1
phorbol-12-myristate-13-acetate-induced protein 1
increases expression
ISO
Diclofenac results in increased expression of PMAIP1 mRNA
CTD
PMID:26934552
NCBI chr18:59,899,996...59,904,305
Ensembl chr18:59,899,996...59,904,305
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PNLIPRP2
pancreatic lipase related protein 2 (gene/pseudogene)
increases expression
ISO
Diclofenac results in increased expression of PNLIPRP2 mRNA
CTD
PMID:26934552
NCBI chr10:116,620,953...116,645,143
Ensembl chr10:116,620,953...116,645,143
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POLE3
DNA polymerase epsilon 3, accessory subunit
affects expression
EXP
Diclofenac affects the expression of POLE3 mRNA
CTD
PMID:24752500
NCBI chr 9:113,407,235...113,410,749
Ensembl chr 9:113,407,235...113,410,675
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POLE4
DNA polymerase epsilon 4, accessory subunit
affects expression
EXP
Diclofenac affects the expression of POLE4 mRNA
CTD
PMID:24752500
NCBI chr 2:74,958,643...74,970,128
Ensembl chr 2:74,958,643...74,970,128
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POLG
DNA polymerase gamma, catalytic subunit
affects expression
EXP
Diclofenac affects the expression of POLG mRNA
CTD
PMID:24752500
NCBI chr15:89,316,320...89,334,824
Ensembl chr15:89,305,198...89,334,861
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POLH
DNA polymerase eta
affects expression
EXP
Diclofenac affects the expression of POLH mRNA
CTD
PMID:24752500
NCBI chr 6:43,576,185...43,620,523
Ensembl chr 6:43,576,185...43,620,523
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POLQ
DNA polymerase theta
affects expression
EXP
Diclofenac affects the expression of POLQ mRNA
CTD
PMID:24752500
NCBI chr 3:121,431,431...121,545,988
Ensembl chr 3:121,431,431...121,545,988
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POLR2F
RNA polymerase II, I and III subunit F
affects expression
EXP
Diclofenac affects the expression of POLR2F mRNA
CTD
PMID:24752500
NCBI chr22:37,953,663...38,041,915
Ensembl chr22:37,952,607...38,041,915
G
POLR3A
RNA polymerase III subunit A
affects expression
EXP
Diclofenac affects the expression of POLR3A mRNA
CTD
PMID:24752500
NCBI chr10:77,975,149...78,029,515
Ensembl chr10:77,953,148...78,029,522
G
POLR3D
RNA polymerase III subunit D
affects expression
EXP
Diclofenac affects the expression of POLR3D mRNA
CTD
PMID:24752500
NCBI chr 8:22,245,133...22,254,601
Ensembl chr 8:22,245,133...22,254,601
G
POLR3G
RNA polymerase III subunit G
increases expression
ISO
Diclofenac results in increased expression of POLR3G mRNA
CTD
PMID:35537566
NCBI chr 5:90,473,929...90,514,557
Ensembl chr 5:90,471,748...90,514,557
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POMK
protein O-mannose kinase
increases expression
ISO
Diclofenac results in increased expression of POMK mRNA
CTD
PMID:26934552
NCBI chr 8:43,093,515...43,123,434
Ensembl chr 8:43,093,498...43,131,180
G
PON1
paraoxonase 1
multiple interactions
EXP
[pyrrolidine analog binds to Palladium binds to Diclofenac] which results in decreased activity of PON1 protein; [pyrrolidine analog binds to Platinum binds to Diclofenac] which results in decreased activity of PON1 protein
CTD
PMID:29512227
NCBI chr 7:95,297,676...95,324,532
Ensembl chr 7:95,297,676...95,324,532
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POR
cytochrome p450 oxidoreductase
affects response to substance increases oxidation
ISO
POR affects the susceptibility to Diclofenac POR results in increased oxidation of Diclofenac
CTD
PMID:25820915
NCBI chr 7:75,915,155...75,986,855
Ensembl chr 7:75,899,200...75,986,855
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POU2AF1
POU class 2 homeobox associating factor 1
decreases expression
ISO
Diclofenac results in decreased expression of POU2AF1 mRNA
CTD
PMID:26934552
NCBI chr11:111,352,255...111,379,275
Ensembl chr11:111,352,255...111,455,630
G
POU2F1
POU class 2 homeobox 1
affects expression
EXP
Diclofenac affects the expression of POU2F1 mRNA
CTD
PMID:24752500
NCBI chr 1:167,220,885...167,427,345
Ensembl chr 1:167,220,876...167,427,345
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POU2F2
POU class 2 homeobox 2
increases expression
ISO
Diclofenac results in increased expression of POU2F2 mRNA
CTD
PMID:26934552
NCBI chr19:42,086,110...42,197,936
Ensembl chr19:42,086,110...42,196,585
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POU2F3
POU class 2 homeobox 3
increases expression
ISO
Diclofenac results in increased expression of POU2F3 mRNA
CTD
PMID:26934552
NCBI chr11:120,236,638...120,319,945
Ensembl chr11:120,236,640...120,319,945
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PPARG
peroxisome proliferator activated receptor gamma
affects expression increases activity multiple interactions
EXP
Diclofenac affects the expression of PPARG mRNA Diclofenac results in increased activity of PPARG protein Diclofenac inhibits the reaction [Rosiglitazone results in increased activity of PPARG protein]
CTD
PMID:12065695 PMID:15273253 PMID:24752500 PMID:28728110 PMID:30138673
NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
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PPARGC1A
PPARG coactivator 1 alpha
affects expression increases expression
EXP ISO
Diclofenac affects the expression of PPARGC1A mRNA Diclofenac results in increased expression of PPARGC1A mRNA
CTD
PMID:24752500 PMID:26934552
NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089
G
PPARGC1B
PPARG coactivator 1 beta
decreases expression
ISO
Diclofenac results in decreased expression of PPARGC1B mRNA
CTD
PMID:26934552
NCBI chr 5:149,730,310...149,857,959
Ensembl chr 5:149,730,298...149,855,022
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PPBP
pro-platelet basic protein
increases expression
ISO
Diclofenac results in increased expression of PPBP mRNA
CTD
PMID:26934552
NCBI chr 4:73,986,439...73,988,190
Ensembl chr 4:73,986,439...73,988,190
G
PPIF
peptidylprolyl isomerase F
increases response to substance
ISO
PPIF results in increased susceptibility to Diclofenac
CTD
PMID:20668000
NCBI chr10:79,347,469...79,355,334
Ensembl chr10:79,347,469...79,355,334
G
PPP1CB
protein phosphatase 1 catalytic subunit beta
affects expression
EXP
Diclofenac affects the expression of PPP1CB mRNA
CTD
PMID:24752500
NCBI chr 2:28,751,604...28,802,940
Ensembl chr 2:28,751,640...28,802,940
G
PPP1R14B
protein phosphatase 1 regulatory inhibitor subunit 14B
affects expression
EXP
Diclofenac affects the expression of PPP1R14B mRNA
CTD
PMID:24752500
NCBI chr11:64,244,479...64,246,943
Ensembl chr11:64,244,479...64,246,943
G
PPP1R15A
protein phosphatase 1 regulatory subunit 15A
affects expression decreases expression
EXP ISO
Diclofenac affects the expression of PPP1R15A mRNA Diclofenac results in decreased expression of PPP1R15A mRNA
CTD
PMID:24752500 PMID:35537566
NCBI chr19:48,872,421...48,876,058
Ensembl chr19:48,872,212...48,876,059
G
PPP1R7
protein phosphatase 1 regulatory subunit 7
affects expression
EXP
Diclofenac affects the expression of PPP1R7 mRNA
CTD
PMID:24752500
NCBI chr 2:241,149,573...241,183,652
Ensembl chr 2:241,149,576...241,183,652
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PPP2R1B
protein phosphatase 2 scaffold subunit Abeta
affects expression
EXP
Diclofenac affects the expression of PPP2R1B mRNA
CTD
PMID:24752500
NCBI chr11:111,688,000...111,766,389
Ensembl chr11:111,726,908...111,766,389
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PPP2R2A
protein phosphatase 2 regulatory subunit Balpha
affects expression
EXP
Diclofenac affects the expression of PPP2R2A mRNA
CTD
PMID:24752500
NCBI chr 8:26,291,508...26,372,680
Ensembl chr 8:26,291,508...26,372,680
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PPP2R2C
protein phosphatase 2 regulatory subunit Bgamma
affects expression
EXP
Diclofenac affects the expression of PPP2R2C mRNA
CTD
PMID:24752500
NCBI chr 4:6,320,581...6,563,799
Ensembl chr 4:6,320,578...6,563,600
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PPP2R5A
protein phosphatase 2 regulatory subunit B'alpha
affects expression
EXP
Diclofenac affects the expression of PPP2R5A mRNA
CTD
PMID:24752500
NCBI chr 1:212,285,410...212,361,853
Ensembl chr 1:212,285,410...212,361,853
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PPP2R5C
protein phosphatase 2 regulatory subunit B'gamma
affects expression
EXP
Diclofenac affects the expression of PPP2R5C mRNA
CTD
PMID:24752500
NCBI chr14:101,760,573...101,927,992
Ensembl chr14:101,761,709...101,927,989
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PRDM1
PR/SET domain 1
decreases expression
ISO
Diclofenac results in decreased expression of PRDM1 mRNA
CTD
PMID:35537566
NCBI chr 6:105,992,690...106,109,938
Ensembl chr 6:105,993,463...106,109,939
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PRG4
proteoglycan 4
increases expression
ISO
Diclofenac results in increased expression of PRG4 mRNA
CTD
PMID:26934552
NCBI chr 1:186,296,273...186,314,567
Ensembl chr 1:186,296,279...186,314,567
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PRKACB
protein kinase cAMP-activated catalytic subunit beta
affects expression
EXP
Diclofenac affects the expression of PRKACB mRNA
CTD
PMID:24752500
NCBI chr 1:84,078,079...84,238,498
Ensembl chr 1:84,078,062...84,238,498
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PRKCA
protein kinase C alpha
affects expression
EXP
Diclofenac affects the expression of PRKCA mRNA
CTD
PMID:24752500
NCBI chr17:66,302,613...66,810,743
Ensembl chr17:66,302,613...66,810,743
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PRKCI
protein kinase C iota
affects expression
EXP
Diclofenac affects the expression of PRKCI mRNA
CTD
PMID:24752500
NCBI chr 3:170,222,424...170,305,977
Ensembl chr 3:170,222,424...170,305,977
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PRKD3
protein kinase D3
affects expression
EXP
Diclofenac affects the expression of PRKD3 mRNA
CTD
PMID:24752500
NCBI chr 2:37,250,502...37,324,833
Ensembl chr 2:37,250,502...37,324,833
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PRKG2
protein kinase cGMP-dependent 2
decreases expression
ISO
Diclofenac results in decreased expression of PRKG2 mRNA
CTD
PMID:35537566
NCBI chr 4:81,087,370...81,217,836
Ensembl chr 4:81,087,370...81,215,222
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PRL
prolactin
decreases expression
ISO
Diclofenac results in decreased expression of PRL mRNA
CTD
PMID:26934552
NCBI chr 6:22,287,246...22,302,835
Ensembl chr 6:22,287,244...22,302,826
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PROCR
protein C receptor
increases expression
ISO
Diclofenac results in increased expression of PROCR mRNA
CTD
PMID:26934552
NCBI chr20:35,171,096...35,216,259
Ensembl chr20:35,172,072...35,216,240
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PROK2
prokineticin 2
increases expression
ISO
Diclofenac results in increased expression of PROK2 mRNA
CTD
PMID:26934552
NCBI chr 3:71,771,655...71,785,148
Ensembl chr 3:71,771,655...71,785,206
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PROS1
protein S
increases expression
ISO
Diclofenac results in increased expression of PROS1 mRNA
CTD
PMID:26934552
NCBI chr 3:93,873,051...93,973,896
Ensembl chr 3:93,873,051...93,980,003
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PRSS3
serine protease 3
decreases expression
ISO
Diclofenac results in decreased expression of PRSS3 mRNA
CTD
PMID:26934552
NCBI chr 9:33,750,679...33,799,231
Ensembl chr 9:33,750,679...33,799,231
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PRTN3
proteinase 3
increases expression
ISO
Diclofenac results in increased expression of PRTN3 mRNA
CTD
PMID:26934552
NCBI chr19:840,999...848,175
Ensembl chr19:840,999...848,175
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PSAT1
phosphoserine aminotransferase 1
affects expression
EXP
Diclofenac affects the expression of PSAT1 mRNA
CTD
PMID:24752500
NCBI chr 9:78,297,125...78,330,093
Ensembl chr 9:78,297,125...78,330,093
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PSG5
pregnancy specific beta-1-glycoprotein 5
increases expression
EXP
Diclofenac results in increased expression of PSG5 mRNA
CTD
PMID:17379860
NCBI chr19:43,167,743...43,186,536
Ensembl chr19:43,166,256...43,186,536
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PSMB4
proteasome 20S subunit beta 4
decreases expression
ISO
Diclofenac results in decreased expression of PSMB4 mRNA
CTD
PMID:18172885
NCBI chr 1:151,399,573...151,401,937
Ensembl chr 1:151,399,560...151,401,937
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PSMD2
proteasome 26S subunit ubiquitin receptor, non-ATPase 2
increases expression
ISO
Diclofenac results in increased expression of PSMD2 mRNA
CTD
PMID:26934552
NCBI chr 3:184,299,241...184,309,050
Ensembl chr 3:184,299,198...184,309,050
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PSMD9
proteasome 26S subunit, non-ATPase 9
decreases expression
ISO
Diclofenac results in decreased expression of PSMD9 mRNA
CTD
PMID:26934552
NCBI chr12:121,888,790...121,918,297
Ensembl chr12:121,888,732...121,918,297
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PSMF1
proteasome inhibitor subunit 1
affects expression
EXP
Diclofenac affects the expression of PSMF1 mRNA
CTD
PMID:24752500
NCBI chr20:1,113,263...1,172,246
Ensembl chr20:1,113,240...1,189,415
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PTEN
phosphatase and tensin homolog
affects expression increases expression
EXP ISO
Diclofenac affects the expression of PTEN mRNA Diclofenac results in increased expression of PTEN mRNA
CTD
PMID:24752500 PMID:26934552
NCBI chr10:87,863,625...87,971,930
Ensembl chr10:87,862,638...87,971,930
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PTGES
prostaglandin E synthase
decreases expression multiple interactions
ISO
Diclofenac results in decreased expression of PTGES mRNA [Diclofenac results in decreased expression of PTGES mRNA] which results in decreased abundance of Dinoprostone
CTD
PMID:19393675
NCBI chr 9:129,738,349...129,753,042
Ensembl chr 9:129,738,331...129,753,042
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PTGFR
prostaglandin F receptor
decreases expression
ISO
Diclofenac results in decreased expression of PTGFR mRNA
CTD
PMID:26934552
NCBI chr 1:78,490,974...78,540,701
Ensembl chr 1:78,303,884...78,540,701
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PTGR1
prostaglandin reductase 1
decreases activity
EXP
Diclofenac results in decreased activity of PTGR1 protein
CTD
PMID:25619643
NCBI chr 9:111,549,722...111,599,647
Ensembl chr 9:111,549,722...111,599,893
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PTGS1
prostaglandin-endoperoxide synthase 1
decreases activity multiple interactions decreases expression increases expression
EXP ISO
Diclofenac analog results in decreased activity of PTGS1 protein; Diclofenac results in decreased activity of PTGS1 protein [thymoquinone co-treated with Diclofenac] results in decreased expression of PTGS1 protein Diclofenac results in decreased expression of PTGS1 protein Diclofenac results in increased expression of PTGS1 mRNA
CTD
PMID:9258749 PMID:12242329 PMID:16141368 PMID:19031110 PMID:26934552 PMID:32220568 More...
NCBI chr 9:122,370,533...122,395,703
Ensembl chr 9:122,370,530...122,395,703
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PTGS2
prostaglandin-endoperoxide synthase 2
multiple interactions decreases expression increases expression decreases activity
EXP ISO
Diclofenac inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]; Diclofenac inhibits the reaction [TNF protein results in increased expression of PTGS2 protein] Diclofenac results in decreased expression of PTGS2 mRNA Diclofenac results in increased expression of PTGS2 mRNA Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 mRNA] Diclofenac results in decreased activity of PTGS2 protein Diclofenac results in increased expression of PTGS2 mRNA; Diclofenac results in increased expression of PTGS2 protein Acetaminophen inhibits the reaction [Diclofenac results in increased expression of PTGS2 protein]; Diclofenac binds to and results in decreased activity of PTGS2 protein; Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of PTGS2 protein]
CTD
PMID:9258749 PMID:9851595 PMID:10594327 PMID:12242329 PMID:12925531 PMID:15489888 PMID:15626590 PMID:15705740 PMID:16793607 PMID:17164136 PMID:19031110 PMID:19192274 PMID:23939143 PMID:31926916 PMID:32816093 More...
NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
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PTK2
protein tyrosine kinase 2
affects expression
EXP
Diclofenac affects the expression of PTK2 mRNA
CTD
PMID:24752500
NCBI chr 8:140,657,900...141,002,079
Ensembl chr 8:140,657,900...141,002,216
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PTPN1
protein tyrosine phosphatase non-receptor type 1
increases expression
ISO
Diclofenac results in increased expression of PTPN1 mRNA
CTD
PMID:26934552
NCBI chr20:50,510,383...50,585,241
Ensembl chr20:50,510,321...50,585,241
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PTPN2
protein tyrosine phosphatase non-receptor type 2
increases expression
ISO
Diclofenac results in increased expression of PTPN2 mRNA
CTD
PMID:26934552
NCBI chr18:12,785,478...12,884,237
Ensembl chr18:12,785,478...12,929,643
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PTPRC
protein tyrosine phosphatase receptor type C
increases expression
ISO
Diclofenac results in increased expression of PTPRC mRNA
CTD
PMID:26934552
NCBI chr 1:198,638,713...198,757,476
Ensembl chr 1:198,638,457...198,757,476
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PTPRJ
protein tyrosine phosphatase receptor type J
increases expression
ISO
Diclofenac results in increased expression of PTPRJ mRNA
CTD
PMID:26934552
NCBI chr11:47,980,559...48,170,839
Ensembl chr11:47,980,425...48,170,839
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PYCARD
PYD and CARD domain containing
multiple interactions
ISO
Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of PYCARD protein]
CTD
PMID:25450234
NCBI chr16:31,201,486...31,202,760
Ensembl chr16:31,201,486...31,203,450
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QSOX1
quiescin sulfhydryl oxidase 1
increases expression
ISO
Diclofenac results in increased expression of QSOX1 mRNA
CTD
PMID:26934552
NCBI chr 1:180,154,869...180,204,030
Ensembl chr 1:180,154,869...180,204,030
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RAB11FIP3
RAB11 family interacting protein 3
increases expression
ISO
Diclofenac results in increased expression of RAB11FIP3 mRNA
CTD
PMID:26934552
NCBI chr16:425,649...523,011
Ensembl chr16:425,649...523,011
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RACK1
receptor for activated C kinase 1
affects expression
EXP
Diclofenac affects the expression of RACK1 mRNA
CTD
PMID:24752500
NCBI chr 5:181,236,897...181,243,906
Ensembl chr 5:181,236,897...181,248,096
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RAD50
RAD50 double strand break repair protein
affects expression
EXP
Diclofenac affects the expression of RAD50 mRNA
CTD
PMID:24752500
NCBI chr 5:132,556,977...132,646,349
Ensembl chr 5:132,556,019...132,646,349
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RAD51
RAD51 recombinase
affects expression increases expression
EXP ISO
Diclofenac affects the expression of RAD51 mRNA Diclofenac results in increased expression of RAD51 mRNA
CTD
PMID:24752500 PMID:30723492
NCBI chr15:40,694,733...40,732,340
Ensembl chr15:40,694,774...40,732,340
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RAET1L
retinoic acid early transcript 1L
decreases expression
ISO
Diclofenac results in decreased expression of RAET1D mRNA
CTD
PMID:26934552
NCBI chr 6:150,018,334...150,025,532
Ensembl chr 6:150,018,334...150,025,532
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RASA1
RAS p21 protein activator 1
affects expression
EXP
Diclofenac affects the expression of RASA1 mRNA
CTD
PMID:24752500
NCBI chr 5:87,267,883...87,391,916
Ensembl chr 5:87,267,883...87,391,931
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RASGEF1B
RasGEF domain family member 1B
decreases expression
ISO
Diclofenac results in decreased expression of RASGEF1B mRNA
CTD
PMID:35537566
NCBI chr 4:81,426,393...81,471,907
Ensembl chr 4:81,426,393...82,044,244
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RB1
RB transcriptional corepressor 1
affects expression
EXP
Diclofenac affects the expression of RB1 mRNA
CTD
PMID:24752500
NCBI chr13:48,303,751...48,481,890
Ensembl chr13:48,303,744...48,599,436
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RBBP8
RB binding protein 8, endonuclease
increases expression decreases expression
ISO
Diclofenac results in increased expression of RBBP8 mRNA Diclofenac results in decreased expression of RBBP8 mRNA
CTD
PMID:26934552 PMID:35537566
NCBI chr18:22,914,139...23,026,486
Ensembl chr18:22,798,261...23,026,488
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RBM3
RNA binding motif protein 3
increases expression
ISO
Diclofenac results in increased expression of RBM3 mRNA
CTD
PMID:26934552
NCBI chr X:48,574,484...48,581,162
Ensembl chr X:48,574,449...48,581,162
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RBX1
ring-box 1
decreases expression
ISO
Diclofenac results in decreased expression of RBX1 mRNA
CTD
PMID:26934552
NCBI chr22:40,951,378...40,973,309
Ensembl chr22:40,951,347...40,973,309
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RCAN1
regulator of calcineurin 1
decreases expression
ISO
Diclofenac results in decreased expression of RCAN1 mRNA
CTD
PMID:35537566
NCBI chr21:34,516,442...34,615,113
Ensembl chr21:34,513,142...34,615,113
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REEP6
receptor accessory protein 6
increases expression
ISO
Diclofenac results in increased expression of REEP6 mRNA
CTD
PMID:35537566
NCBI chr19:1,491,181...1,497,927
Ensembl chr19:1,491,166...1,497,927
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REG3A
regenerating family member 3 alpha
increases expression
ISO
Diclofenac results in increased expression of REG3B mRNA
CTD
PMID:26934552
NCBI chr 2:79,157,006...79,159,753
Ensembl chr 2:79,157,003...79,159,753
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REG3G
regenerating family member 3 gamma
increases expression
ISO
Diclofenac results in increased expression of REG3G mRNA
CTD
PMID:26934552
NCBI chr 2:79,025,702...79,028,501
Ensembl chr 2:79,025,686...79,028,505
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RELA
RELA proto-oncogene, NF-kB subunit
multiple interactions affects expression
EXP ISO
Diclofenac inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Diclofenac inhibits the reaction [TNF protein results in increased activity of RELA protein] Diclofenac affects the expression of RELA mRNA Diclofenac inhibits the reaction [Freund's Adjuvant results in increased phosphorylation of RELA protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; RELA mutant form inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]
CTD
PMID:15489888 PMID:19393675 PMID:24752500 PMID:25935278
NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090
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RELN
reelin
decreases expression
ISO
Diclofenac results in decreased expression of RELN mRNA
CTD
PMID:26934552
NCBI chr 7:103,471,789...103,989,658
Ensembl chr 7:103,471,381...103,989,658
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RET
ret proto-oncogene
increases expression
ISO
Diclofenac results in increased expression of RET mRNA
CTD
PMID:26934552
NCBI chr10:43,077,069...43,130,351
Ensembl chr10:43,077,064...43,130,351
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REV3L
REV3 like, DNA directed polymerase zeta catalytic subunit
affects expression
EXP
Diclofenac affects the expression of REV3L mRNA
CTD
PMID:24752500
NCBI chr 6:111,299,033...111,483,711
Ensembl chr 6:111,299,028...111,483,715
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RGN
regucalcin
increases expression
ISO
Diclofenac results in increased expression of RGN mRNA
CTD
PMID:19022234
NCBI chr X:47,078,443...47,093,313
Ensembl chr X:47,078,355...47,093,314
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RGS16
regulator of G protein signaling 16
decreases expression
ISO
Diclofenac results in decreased expression of RGS16 mRNA
CTD
PMID:35537566
NCBI chr 1:182,598,623...182,604,389
Ensembl chr 1:182,598,623...182,604,389
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RGS2
regulator of G protein signaling 2
decreases expression
ISO
Diclofenac results in decreased expression of RGS2 mRNA
CTD
PMID:35537566
NCBI chr 1:192,809,039...192,812,275
Ensembl chr 1:192,809,039...192,812,275
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RGS4
regulator of G protein signaling 4
decreases expression
EXP
Diclofenac results in decreased expression of RGS4 mRNA
CTD
PMID:19192274
NCBI chr 1:163,068,871...163,076,802
Ensembl chr 1:163,068,775...163,076,802
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RHOB
ras homolog family member B
affects expression
EXP
Diclofenac affects the expression of RHOB mRNA
CTD
PMID:24752500
NCBI chr 2:20,447,074...20,449,440
Ensembl chr 2:20,447,074...20,449,440
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RHOJ
ras homolog family member J
decreases expression
ISO
Diclofenac results in decreased expression of RHOJ mRNA
CTD
PMID:35537566
NCBI chr14:63,204,443...63,293,508
Ensembl chr14:63,204,114...63,293,508
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RHOQ
ras homolog family member Q
affects expression
EXP
Diclofenac affects the expression of RHOQ mRNA
CTD
PMID:24752500
NCBI chr 2:46,542,490...46,584,688
Ensembl chr 2:46,541,806...46,584,688
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RHOT2
ras homolog family member T2
affects expression
EXP
Diclofenac affects the expression of RHOT2 mRNA
CTD
PMID:24752500
NCBI chr16:668,083...674,174
Ensembl chr16:668,100...674,174
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RIC8A
RIC8 guanine nucleotide exchange factor A
decreases expression
ISO
Diclofenac results in decreased expression of RIC8A mRNA
CTD
PMID:35537566
NCBI chr11:207,708...215,113
Ensembl chr11:207,708...215,113
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RIGI
RNA sensor RIG-I
decreases expression
EXP
Diclofenac results in decreased expression of RIGI mRNA
CTD
PMID:19192274
NCBI chr 9:32,455,302...32,526,196
Ensembl chr 9:32,455,302...32,526,348
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RNASE6
ribonuclease A family member k6
increases expression
ISO
Diclofenac results in increased expression of RNASE6 mRNA
CTD
PMID:30723492
NCBI chr14:20,781,070...20,782,467
Ensembl chr14:20,781,268...20,782,467
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RNASEL
ribonuclease L
increases expression
ISO
Diclofenac results in increased expression of RNASEL mRNA
CTD
PMID:26934552
NCBI chr 1:182,573,634...182,589,256
Ensembl chr 1:182,573,634...182,589,256
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RND1
Rho family GTPase 1
decreases expression
ISO
Diclofenac results in decreased expression of RND1 mRNA
CTD
PMID:35537566
NCBI chr12:48,857,145...48,865,870
Ensembl chr12:48,857,145...48,865,870
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RNF145
ring finger protein 145
increases expression
ISO
Diclofenac results in increased expression of RNF145 mRNA
CTD
PMID:35537566
NCBI chr 5:159,157,409...159,210,053
Ensembl chr 5:159,157,409...159,210,053
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RNF19B
ring finger protein 19B
decreases expression
EXP
Diclofenac results in decreased expression of RNF19B mRNA
CTD
PMID:19192274
NCBI chr 1:32,929,036...32,964,809
Ensembl chr 1:32,936,445...32,964,809
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ROCK1
Rho associated coiled-coil containing protein kinase 1
affects expression
EXP
Diclofenac affects the expression of ROCK1 mRNA
CTD
PMID:24752500
NCBI chr18:20,946,906...21,111,813
Ensembl chr18:20,944,612...21,111,813
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ROCK2
Rho associated coiled-coil containing protein kinase 2
affects expression
EXP
Diclofenac affects the expression of ROCK2 mRNA
CTD
PMID:24752500
NCBI chr 2:11,179,759...11,345,437
Ensembl chr 2:11,179,759...11,348,330
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ROPN1L
rhophilin associated tail protein 1 like
increases expression
ISO
Diclofenac results in increased expression of ROPN1L mRNA
CTD
PMID:35537566
NCBI chr 5:10,441,879...10,482,807
Ensembl chr 5:10,441,524...10,472,029 Ensembl chr 5:10,441,524...10,472,029
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RORA
RAR related orphan receptor A
decreases expression
ISO
Diclofenac results in decreased expression of RORA mRNA
CTD
PMID:26934552
NCBI chr15:60,488,284...61,229,302
Ensembl chr15:60,488,284...61,229,302
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RORC
RAR related orphan receptor C
increases expression
ISO
Diclofenac results in increased expression of RORC mRNA
CTD
PMID:22285467
NCBI chr 1:151,806,071...151,831,802
Ensembl chr 1:151,806,071...151,831,845
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RPA1
replication protein A1
affects expression
EXP
Diclofenac affects the expression of RPA1 mRNA
CTD
PMID:24752500
NCBI chr17:1,830,005...1,900,082
Ensembl chr17:1,829,702...1,900,082
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RPA2
replication protein A2
affects expression
EXP
Diclofenac affects the expression of RPA2 mRNA
CTD
PMID:24752500
NCBI chr 1:27,891,524...27,914,797
Ensembl chr 1:27,891,524...27,914,746
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RPAP3
RNA polymerase II associated protein 3
increases expression
ISO
Diclofenac results in increased expression of RPAP3 mRNA
CTD
PMID:26934552
NCBI chr12:47,661,249...47,706,030
Ensembl chr12:47,661,249...47,706,030
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RPL39L
ribosomal protein L39 like
increases expression
ISO
Diclofenac results in increased expression of RPL39L mRNA
CTD
PMID:26934552
NCBI chr 3:187,120,948...187,139,496
Ensembl chr 3:187,120,948...187,180,908
G
RPS6KA1
ribosomal protein S6 kinase A1
affects expression
EXP
Diclofenac affects the expression of RPS6KA1 mRNA
CTD
PMID:24752500
NCBI chr 1:26,529,761...26,575,025
Ensembl chr 1:26,529,761...26,575,030
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RPS6KA5
ribosomal protein S6 kinase A5
decreases expression
ISO
Diclofenac results in decreased expression of RPS6KA5 mRNA
CTD
PMID:26934552
NCBI chr14:90,847,861...91,060,641
Ensembl chr14:90,847,861...91,060,641
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RPS6KL1
ribosomal protein S6 kinase like 1
increases expression
ISO
Diclofenac results in increased expression of RPS6KL1 mRNA
CTD
PMID:30723492
NCBI chr14:74,903,951...74,923,260
Ensembl chr14:74,903,951...74,923,302
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RRAS2
RAS related 2
affects expression
EXP
Diclofenac affects the expression of RRAS2 mRNA
CTD
PMID:24752500
NCBI chr11:14,277,920...14,364,506
Ensembl chr11:14,277,922...14,364,506
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RSAD2
radical S-adenosyl methionine domain containing 2
decreases expression
EXP
Diclofenac results in decreased expression of RSAD2 mRNA
CTD
PMID:19192274
NCBI chr 2:6,865,885...6,898,239
Ensembl chr 2:6,865,557...6,898,239
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RUNX2
RUNX family transcription factor 2
increases expression
ISO
Diclofenac results in increased expression of RUNX2 mRNA
CTD
PMID:30723492
NCBI chr 6:45,328,330...45,551,082
Ensembl chr 6:45,328,157...45,664,349
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S100A8
S100 calcium binding protein A8
increases expression
ISO EXP
Diclofenac results in increased expression of S100A8 mRNA
CTD
PMID:24747151 PMID:26934552 PMID:28138970
NCBI chr 1:153,390,032...153,422,583
Ensembl chr 1:153,390,032...153,391,073
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S100A9
S100 calcium binding protein A9
increases expression
ISO EXP
Diclofenac results in increased expression of S100A9 mRNA
CTD
PMID:24747151 PMID:26934552 PMID:27671914 PMID:28138970
NCBI chr 1:153,357,854...153,361,023
Ensembl chr 1:153,357,854...153,361,023
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SAA1
serum amyloid A1
increases expression
ISO
Diclofenac results in increased expression of SAA1 mRNA
CTD
PMID:26934552
NCBI chr11:18,266,264...18,269,967
Ensembl chr11:18,266,260...18,269,977
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SAA2
serum amyloid A2
increases expression
ISO
Diclofenac results in increased expression of SAA2 mRNA
CTD
PMID:26934552
NCBI chr11:18,238,236...18,248,668
Ensembl chr11:18,239,223...18,248,668
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SAA3P
serum amyloid A3, pseudogene
increases expression
ISO
Diclofenac results in increased expression of SAA3 mRNA
CTD
PMID:26934552
NCBI chr11:18,112,472...18,116,132
Ensembl chr11:18,112,472...18,116,132 Ensembl chr11:18,112,472...18,116,132
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SAA4
serum amyloid A4, constitutive
increases expression decreases expression
ISO
Diclofenac results in increased expression of SAA4 mRNA Diclofenac results in decreased expression of SAA4 mRNA
CTD
PMID:26934552
NCBI chr11:18,231,355...18,236,802
Ensembl chr11:18,231,355...18,236,802
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SARM1
sterile alpha and TIR motif containing 1
increases expression
ISO
Diclofenac results in increased expression of SARM1 mRNA
CTD
PMID:26934552
NCBI chr17:28,371,694...28,404,049
Ensembl chr17:28,364,356...28,404,049
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SARS1
seryl-tRNA synthetase 1
affects expression
EXP
Diclofenac affects the expression of SARS1 mRNA
CTD
PMID:24752500
NCBI chr 1:109,213,893...109,238,182
Ensembl chr 1:109,213,918...109,238,182
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SAT1
spermidine/spermine N1-acetyltransferase 1
affects expression
EXP
Diclofenac affects the expression of SAT1 mRNA
CTD
PMID:24752500
NCBI chr X:23,783,173...23,786,210
Ensembl chr X:23,783,173...23,786,210
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SAT2
spermidine/spermine N1-acetyltransferase family member 2
affects expression
EXP
Diclofenac affects the expression of SAT2 mRNA
CTD
PMID:24752500
NCBI chr17:7,626,234...7,627,876
Ensembl chr17:7,626,234...7,627,876
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SCARA5
scavenger receptor class A member 5
increases expression
ISO
Diclofenac results in increased expression of SCARA5 mRNA
CTD
PMID:26934552
NCBI chr 8:27,869,883...27,992,673
Ensembl chr 8:27,869,883...27,992,673
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SCN5A
sodium voltage-gated channel alpha subunit 5
decreases activity
EXP
Diclofenac results in decreased activity of SCN5A protein
CTD
PMID:33617802
NCBI chr 3:38,548,062...38,649,687
Ensembl chr 3:38,548,057...38,649,743
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SELE
selectin E
increases expression
ISO
Diclofenac results in increased expression of SELE mRNA
CTD
PMID:26934552
NCBI chr 1:169,722,640...169,734,079
Ensembl chr 1:169,722,640...169,764,705
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SELL
selectin L
decreases expression increases expression
EXP ISO
Diclofenac results in decreased expression of SELL protein Diclofenac results in increased expression of SELL mRNA
CTD
PMID:12147693 PMID:26934552
NCBI chr 1:169,690,667...169,711,620
Ensembl chr 1:169,690,665...169,711,702
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SELP
selectin P
decreases expression multiple interactions
ISO
Diclofenac results in decreased expression of SELP protein Enalapril inhibits the reaction [Diclofenac results in decreased expression of SELP protein]
CTD
PMID:14716214
NCBI chr 1:169,588,849...169,630,124
Ensembl chr 1:169,588,849...169,630,193
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SEMA4B
semaphorin 4B
increases expression
ISO
Diclofenac results in increased expression of SEMA4B mRNA
CTD
PMID:26934552
NCBI chr15:90,184,920...90,229,661
Ensembl chr15:90,160,604...90,229,679
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SERPINA10
serpin family A member 10
decreases expression increases expression
ISO
Diclofenac results in decreased expression of SERPINA10 mRNA Diclofenac results in increased expression of SERPINA10 mRNA
CTD
PMID:26934552
NCBI chr14:94,280,460...94,293,268
Ensembl chr14:94,280,460...94,293,268
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SERPINA12
serpin family A member 12
increases expression
ISO
Diclofenac results in increased expression of SERPINA12 mRNA
CTD
PMID:30723492
NCBI chr14:94,487,279...94,517,844
Ensembl chr14:94,487,274...94,517,844
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SERPINA3
serpin family A member 3
multiple interactions
ISO
[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of SERPINA3N protein
CTD
PMID:25772430
NCBI chr14:94,612,391...94,624,053
Ensembl chr14:94,612,384...94,624,055
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SERPINE1
serpin family E member 1
multiple interactions affects expression increases expression
ISO EXP
Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of SERPINE1 mRNA] Diclofenac affects the expression of SERPINE1 mRNA Diclofenac results in increased expression of SERPINE1 mRNA
CTD
PMID:23939143 PMID:24752500 PMID:26934552 PMID:35537566
NCBI chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247
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SERPINE2
serpin family E member 2
decreases expression
ISO
Diclofenac results in decreased expression of SERPINE2 mRNA
CTD
PMID:26934552
NCBI chr 2:223,975,045...224,039,286
Ensembl chr 2:223,975,045...224,039,318
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SERPINF2
serpin family F member 2
increases expression
ISO
Diclofenac results in increased expression of SERPINF2 mRNA
CTD
PMID:26934552
NCBI chr17:1,742,871...1,755,265
Ensembl chr17:1,742,836...1,755,265
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SERPINH1
serpin family H member 1
decreases expression
ISO
Diclofenac results in decreased expression of SERPINH1 mRNA
CTD
PMID:26934552
NCBI chr11:75,562,253...75,572,783
Ensembl chr11:75,562,056...75,572,783
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SFN
stratifin
increases expression
EXP
Diclofenac results in increased expression of SFN mRNA
CTD
PMID:17379860
NCBI chr 1:26,863,149...26,864,456
Ensembl chr 1:26,863,149...26,864,456
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SFPQ
splicing factor proline and glutamine rich
increases expression
ISO
Diclofenac results in increased expression of SFPQ mRNA
CTD
PMID:26934552
NCBI chr 1:35,176,380...35,193,145
Ensembl chr 1:35,176,378...35,193,446
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SGK1
serum/glucocorticoid regulated kinase 1
increases expression decreases expression
ISO
Diclofenac results in increased expression of SGK1 mRNA Diclofenac results in decreased expression of SGK1 mRNA
CTD
PMID:30723492 PMID:35537566
NCBI chr 6:134,169,256...134,318,112
Ensembl chr 6:134,169,248...134,318,112
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SGK2
serum/glucocorticoid regulated kinase 2
decreases expression
ISO
Diclofenac results in decreased expression of SGK2 mRNA
CTD
PMID:26934552
NCBI chr20:43,559,027...43,585,627
Ensembl chr20:43,558,968...43,588,237
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SH3GLB1
SH3 domain containing GRB2 like, endophilin B1
affects expression
EXP
Diclofenac affects the expression of SH3GLB1 mRNA
CTD
PMID:24752500
NCBI chr 1:86,704,576...86,748,184
Ensembl chr 1:86,704,570...86,748,184
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SHISA6
shisa family member 6
decreases expression
ISO
Diclofenac results in decreased expression of SHISA6 mRNA
CTD
PMID:26934552
NCBI chr17:11,241,213...11,564,063
Ensembl chr17:11,241,213...11,564,063
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SHMT1
serine hydroxymethyltransferase 1
affects expression
EXP
Diclofenac affects the expression of SHMT1 mRNA
CTD
PMID:24752500
NCBI chr17:18,327,873...18,363,550
Ensembl chr17:18,327,873...18,363,550
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SHPRH
SNF2 histone linker PHD RING helicase
decreases expression
ISO
Diclofenac results in decreased expression of SHPRH mRNA
CTD
PMID:26934552
NCBI chr 6:145,857,838...145,964,358
Ensembl chr 6:145,864,245...145,964,423
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SIK1
salt inducible kinase 1
increases expression
ISO
Diclofenac results in increased expression of SIK1 mRNA
CTD
PMID:35537566
NCBI chr21:43,414,483...43,427,131
Ensembl chr21:43,414,483...43,427,131
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SIN3A
SIN3 transcription regulator family member A
affects expression
EXP
Diclofenac affects the expression of SIN3A mRNA
CTD
PMID:24752500
NCBI chr15:75,369,379...75,455,815
Ensembl chr15:75,369,379...75,455,842
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SKA1
spindle and kinetochore associated complex subunit 1
increases expression
ISO
Diclofenac results in increased expression of SKA1 mRNA
CTD
PMID:30723492
NCBI chr18:50,375,046...50,394,168
Ensembl chr18:50,375,040...50,394,168
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SLC10A2
solute carrier family 10 member 2
increases expression
ISO
Diclofenac results in increased expression of SLC10A2 mRNA
CTD
PMID:26934552
NCBI chr13:103,043,998...103,066,417
Ensembl chr13:103,043,998...103,066,417
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SLC10A6
solute carrier family 10 member 6
increases expression
ISO
Diclofenac results in increased expression of SLC10A6 mRNA
CTD
PMID:26934552
NCBI chr 4:86,823,468...86,849,384
Ensembl chr 4:86,823,468...86,849,384
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SLC13A3
solute carrier family 13 member 3
increases expression
ISO
Diclofenac results in increased expression of SLC13A3 mRNA
CTD
PMID:26934552
NCBI chr20:46,557,828...46,684,485
Ensembl chr20:46,557,823...46,684,467
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SLC15A2
solute carrier family 15 member 2
decreases expression
ISO
Diclofenac results in decreased expression of SLC15A2 mRNA
CTD
PMID:26934552
NCBI chr 3:121,894,401...121,944,188
Ensembl chr 3:121,894,401...121,944,188
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SLC16A5
solute carrier family 16 member 5
increases expression
ISO
Diclofenac results in increased expression of SLC16A5 mRNA
CTD
PMID:26934552
NCBI chr17:75,087,385...75,110,149
Ensembl chr17:75,087,727...75,106,162
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SLC17A6
solute carrier family 17 member 6
increases expression
ISO
Diclofenac results in increased expression of SLC17A6 mRNA
CTD
PMID:26934552
NCBI chr11:22,338,381...22,379,503
Ensembl chr11:22,338,381...22,379,503
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SLC19A1
solute carrier family 19 member 1
affects expression
EXP
Diclofenac affects the expression of SLC19A1 mRNA
CTD
PMID:24752500
NCBI chr21:45,502,517...45,563,025
Ensembl chr21:45,493,572...45,573,365
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SLC19A2
solute carrier family 19 member 2
increases expression
ISO
Diclofenac results in increased expression of SLC19A2 mRNA
CTD
PMID:35537566
NCBI chr 1:169,463,909...169,485,970
Ensembl chr 1:169,463,909...169,485,944
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SLC1A4
solute carrier family 1 member 4
increases expression decreases expression
ISO
Diclofenac results in increased expression of SLC1A4 mRNA Diclofenac results in decreased expression of SLC1A4 mRNA
CTD
PMID:26934552 PMID:35537566
NCBI chr 2:64,988,479...65,023,865
Ensembl chr 2:64,988,477...65,023,865
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SLC22A1
solute carrier family 22 member 1
decreases activity
EXP
Diclofenac results in decreased activity of SLC22A1 protein
CTD
PMID:12388633
NCBI chr 6:160,121,815...160,158,718
Ensembl chr 6:160,121,815...160,158,718
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SLC22A11
solute carrier family 22 member 11
decreases activity multiple interactions
EXP
Diclofenac results in decreased activity of SLC22A11 protein Diclofenac inhibits the reaction [SLC22A11 protein affects the transport of estrone sulfate]
CTD
PMID:10660625 PMID:12388633
NCBI chr11:64,555,941...64,572,875
Ensembl chr11:64,555,690...64,572,875
G
SLC22A6
solute carrier family 22 member 6
decreases activity
EXP
Diclofenac results in decreased activity of SLC22A6 protein
CTD
PMID:12388633
NCBI chr11:62,976,597...62,984,967
Ensembl chr11:62,936,385...62,984,967
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SLC22A7
solute carrier family 22 member 7
decreases activity multiple interactions
EXP
Diclofenac results in decreased activity of SLC22A7 protein Diclofenac inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline]
CTD
PMID:12388633 PMID:15901346
NCBI chr 6:43,295,714...43,305,538
Ensembl chr 6:43,295,694...43,305,538
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SLC22A8
solute carrier family 22 member 8
multiple interactions
EXP
Diclofenac inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]
CTD
PMID:11306713
NCBI chr11:62,992,824...63,015,841
Ensembl chr11:62,989,154...63,015,841
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SLC22A9
solute carrier family 22 member 9
decreases activity multiple interactions
EXP ISO
Diclofenac results in decreased activity of SLC22A9 protein Diclofenac inhibits the reaction [SLC22A19 protein affects the transport of estrone sulfate]
CTD
PMID:12388633 PMID:16079298
NCBI chr11:63,369,785...63,410,294
Ensembl chr11:63,369,785...63,410,294
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SLC23A1
solute carrier family 23 member 1
increases expression
ISO
Diclofenac results in increased expression of SLC23A1 mRNA
CTD
PMID:26934552
NCBI chr 5:139,367,196...139,385,676
Ensembl chr 5:139,367,196...139,384,553
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SLC23A2
solute carrier family 23 member 2
multiple interactions
EXP
Diclofenac inhibits the reaction [SLC23A2 protein results in increased uptake of Ascorbic Acid]
CTD
PMID:17092984
NCBI chr20:4,852,358...5,010,313
Ensembl chr20:4,852,356...5,010,293
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SLC25A22
solute carrier family 25 member 22
decreases expression
ISO
Diclofenac results in decreased expression of SLC25A22 mRNA
CTD
PMID:26934552
NCBI chr11:790,475...798,281
Ensembl chr11:790,475...798,281
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SLC25A30
solute carrier family 25 member 30
decreases expression
ISO
Diclofenac results in decreased expression of SLC25A30 mRNA
CTD
PMID:26934552
NCBI chr13:45,393,316...45,434,016
Ensembl chr13:45,393,316...45,418,455
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SLC25A33
solute carrier family 25 member 33
decreases expression
ISO
Diclofenac results in decreased expression of SLC25A33 mRNA
CTD
PMID:26934552
NCBI chr 1:9,539,465...9,585,173
Ensembl chr 1:9,539,465...9,585,173
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SLC29A1
solute carrier family 29 member 1 (Augustine blood group)
decreases expression
ISO
Diclofenac results in decreased expression of SLC29A1 mRNA
CTD
PMID:26934552
NCBI chr 6:44,219,615...44,234,142
Ensembl chr 6:44,219,553...44,234,142
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SLC2A2
solute carrier family 2 member 2
decreases expression
ISO
Diclofenac results in decreased expression of SLC2A2 mRNA
CTD
PMID:26934552
NCBI chr 3:170,996,347...171,026,720
Ensembl chr 3:170,996,347...171,026,743
G
SLC30A5
solute carrier family 30 member 5
increases expression
ISO
Diclofenac results in increased expression of SLC30A5 mRNA
CTD
PMID:26934552
NCBI chr 5:69,094,014...69,131,069
Ensembl chr 5:69,093,991...69,131,069
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SLC36A4
solute carrier family 36 member 4
increases expression
ISO
Diclofenac results in increased expression of SLC36A4 mRNA
CTD
PMID:26934552
NCBI chr11:93,144,174...93,197,991
Ensembl chr11:93,144,174...93,197,991
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SLC37A1
solute carrier family 37 member 1
increases expression
ISO
Diclofenac results in increased expression of SLC37A1 mRNA
CTD
PMID:26934552
NCBI chr21:42,499,622...42,581,426
Ensembl chr21:42,496,008...42,581,440
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SLC38A7
solute carrier family 38 member 7
decreases expression
ISO
Diclofenac results in decreased expression of SLC38A7 mRNA
CTD
PMID:35537566
NCBI chr16:58,665,109...58,684,770
Ensembl chr16:58,665,109...58,684,770
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SLC39A14
solute carrier family 39 member 14
increases expression
ISO
Diclofenac results in increased expression of SLC39A14 mRNA
CTD
PMID:26934552
NCBI chr 8:22,367,278...22,434,129
Ensembl chr 8:22,367,278...22,434,129
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SLC3A1
solute carrier family 3 member 1
increases expression
ISO
Diclofenac results in increased expression of SLC3A1 mRNA
CTD
PMID:26934552
NCBI chr 2:44,275,480...44,322,437
Ensembl chr 2:44,275,458...44,321,494
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SLC41A1
solute carrier family 41 member 1
increases expression
ISO
Diclofenac results in increased expression of SLC41A1 mRNA
CTD
PMID:26934552
NCBI chr 1:205,789,095...205,813,198
Ensembl chr 1:205,789,094...205,813,748
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SLC41A2
solute carrier family 41 member 2
increases expression
ISO
Diclofenac results in increased expression of SLC41A2 mRNA
CTD
PMID:26934552
NCBI chr12:104,801,801...104,958,746
Ensembl chr12:104,801,801...104,958,744
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SLC43A1
solute carrier family 43 member 1
increases expression
ISO
Diclofenac results in increased expression of SLC43A1 mRNA
CTD
PMID:26934552
NCBI chr11:57,484,534...57,515,702
Ensembl chr11:57,484,534...57,515,780
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SLC45A4
solute carrier family 45 member 4
decreases expression
ISO
Diclofenac results in decreased expression of SLC45A4 mRNA
CTD
PMID:26934552
NCBI chr 8:141,207,174...141,308,288
Ensembl chr 8:141,207,166...141,308,305
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SLC46A2
solute carrier family 46 member 2
decreases expression
ISO
Diclofenac results in decreased expression of SLC46A2 mRNA
CTD
PMID:26934552
NCBI chr 9:112,878,920...112,890,876
Ensembl chr 9:112,878,920...112,890,876
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SLC46A3
solute carrier family 46 member 3
decreases expression
ISO
Diclofenac results in decreased expression of SLC46A3 mRNA
CTD
PMID:35537566
NCBI chr13:28,700,080...28,718,970
Ensembl chr13:28,700,064...28,718,970
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SLC4A1
solute carrier family 4 member 1 (Diego blood group)
increases expression
ISO
Diclofenac results in increased expression of SLC4A1 mRNA
CTD
PMID:26934552
NCBI chr17:44,248,390...44,268,135
Ensembl chr17:44,248,390...44,268,141
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SLC4A4
solute carrier family 4 member 4
increases expression
ISO
Diclofenac results in increased expression of SLC4A4 mRNA
CTD
PMID:26934552
NCBI chr 4:71,062,660...71,572,083
Ensembl chr 4:71,062,667...71,572,087
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SLC6A9
solute carrier family 6 member 9
decreases expression
ISO
Diclofenac results in decreased expression of SLC6A9 mRNA
CTD
PMID:35537566
NCBI chr 1:43,996,483...44,031,462
Ensembl chr 1:43,991,500...44,031,467
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SLC7A1
solute carrier family 7 member 1
decreases expression
ISO
Diclofenac results in decreased expression of SLC7A1 mRNA
CTD
PMID:35537566
NCBI chr13:29,509,414...29,595,688
Ensembl chr13:29,509,414...29,595,688
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SLC7A11
solute carrier family 7 member 11
decreases expression increases expression
EXP ISO
Diclofenac results in decreased expression of SLC7A11 mRNA Diclofenac results in increased expression of SLC7A11 mRNA
CTD
PMID:19192274 PMID:32816093 PMID:33785417 PMID:35537566
NCBI chr 4:138,164,097...138,312,671
Ensembl chr 4:138,164,097...138,242,349
G
SLC7A3
solute carrier family 7 member 3
increases expression
ISO
Diclofenac results in increased expression of SLC7A3 mRNA
CTD
PMID:26934552
NCBI chr X:70,925,579...70,931,096
Ensembl chr X:70,925,579...70,931,125
G
SLC7A4
solute carrier family 7 member 4
increases expression
ISO
Diclofenac results in increased expression of SLC7A4 mRNA
CTD
PMID:26934552
NCBI chr22:21,028,718...21,032,561
Ensembl chr22:21,028,718...21,032,840
G
SLC7A5
solute carrier family 7 member 5
decreases expression
ISO
Diclofenac results in decreased expression of SLC7A5 mRNA
CTD
PMID:35537566
NCBI chr16:87,830,023...87,869,507
Ensembl chr16:87,830,023...87,869,507
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SLC7A8
solute carrier family 7 member 8
increases expression
EXP ISO
Diclofenac results in increased expression of SLC7A8 mRNA
CTD
PMID:19192274 PMID:26934552
NCBI chr14:23,125,295...23,183,660
Ensembl chr14:23,125,295...23,183,674
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SLCO2A1
solute carrier organic anion transporter family member 2A1
multiple interactions
EXP
Diclofenac inhibits the reaction [SLCO2A1 protein results in increased transport of Dinoprostone]
CTD
PMID:19843975
NCBI chr 3:133,932,701...134,029,925
Ensembl chr 3:133,932,701...134,052,184
G
SLITRK5
SLIT and NTRK like family member 5
increases expression
ISO
Diclofenac results in increased expression of SLITRK5 mRNA
CTD
PMID:30723492
NCBI chr13:87,671,371...87,679,616
Ensembl chr13:87,671,371...87,696,272
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SLPI
secretory leukocyte peptidase inhibitor
increases expression
EXP
Diclofenac results in increased expression of SLPI mRNA
CTD
PMID:32816093
NCBI chr20:45,252,239...45,254,564
Ensembl chr20:45,252,239...45,254,564
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SMAD1
SMAD family member 1
increases expression
ISO
Diclofenac results in increased expression of SMAD1 mRNA
CTD
PMID:26934552
NCBI chr 4:145,480,770...145,559,176
Ensembl chr 4:145,481,194...145,559,176
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SMAD4
SMAD family member 4
affects expression
EXP
Diclofenac affects the expression of SMAD4 mRNA
CTD
PMID:24752500
NCBI chr18:51,030,213...51,085,042
Ensembl chr18:51,028,528...51,085,045
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SMARCA5
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
increases expression
ISO
Diclofenac results in increased expression of SMARCA5 mRNA
CTD
PMID:26934552
NCBI chr 4:143,513,702...143,557,486
Ensembl chr 4:143,513,702...143,557,486
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SMARCB1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
increases expression
ISO
Diclofenac results in increased expression of SMARCB1 mRNA
CTD
PMID:26934552
NCBI chr22:23,786,966...23,838,009
Ensembl chr22:23,786,931...23,838,009
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SNCA
synuclein alpha
increases expression
ISO
Diclofenac results in increased expression of SNCA mRNA
CTD
PMID:26934552
NCBI chr 4:89,724,099...89,838,304
Ensembl chr 4:89,700,345...89,838,315
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SNORD14E
small nucleolar RNA, C/D box 14E
increases expression
ISO
Diclofenac results in increased expression of SNORD14E mRNA
CTD
PMID:35537566
NCBI chr11:123,058,077...123,058,156
Ensembl chr11:123,058,077...123,058,161
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SNX10
sorting nexin 10
increases expression
ISO
Diclofenac results in increased expression of SNX10 mRNA
CTD
PMID:26934552
NCBI chr 7:26,291,862...26,374,383
Ensembl chr 7:26,291,862...26,374,383
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SOAT2
sterol O-acyltransferase 2
decreases expression
ISO
Diclofenac results in decreased expression of SOAT2 mRNA
CTD
PMID:35537566
NCBI chr12:53,103,486...53,124,535
Ensembl chr12:53,103,486...53,124,535
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SOCS3
suppressor of cytokine signaling 3
increases expression
ISO
Diclofenac results in increased expression of SOCS3 mRNA
CTD
PMID:26934552 PMID:35537566
NCBI chr17:78,356,778...78,360,925
Ensembl chr17:78,356,778...78,360,077
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SOCS6
suppressor of cytokine signaling 6
affects expression
EXP
Diclofenac affects the expression of SOCS6 mRNA
CTD
PMID:24752500
NCBI chr18:70,289,045...70,330,199
Ensembl chr18:70,289,045...70,330,199
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SOCS7
suppressor of cytokine signaling 7
affects expression
EXP
Diclofenac affects the expression of SOCS7 mRNA
CTD
PMID:24752500
NCBI chr17:38,351,844...38,405,593
Ensembl chr17:38,351,844...38,405,593
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SOD1
superoxide dismutase 1
increases secretion increases expression multiple interactions decreases activity
ISO EXP
Diclofenac results in increased secretion of SOD1 protein Diclofenac results in increased expression of SOD1 mRNA Acetylcysteine inhibits the reaction [Diclofenac results in decreased activity of SOD1 protein]; Silymarin inhibits the reaction [Diclofenac results in decreased activity of SOD1 protein]
CTD
PMID:24038040 PMID:28535741 PMID:29027214
NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931
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SOD2
superoxide dismutase 2
increases expression multiple interactions affects expression
ISO EXP
Diclofenac results in increased expression of SOD2 mRNA; Diclofenac results in increased expression of SOD2 protein [Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of SOD2 protein; Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of SOD2 mRNA]; rebamipide promotes the reaction [Diclofenac results in increased expression of SOD2 protein] Diclofenac affects the expression of SOD2 mRNA
CTD
PMID:19022234 PMID:22653900 PMID:23939143 PMID:24752500 PMID:25772430 PMID:27313093 More...
NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
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SORD
sorbitol dehydrogenase
multiple interactions increases secretion
ISO
Acetylcysteine inhibits the reaction [Diclofenac results in increased secretion of SORD protein]; Buthionine Sulfoximine promotes the reaction [Diclofenac results in increased secretion of SORD protein]
CTD
PMID:12763371
NCBI chr15:45,023,195...45,077,185
Ensembl chr15:45,023,147...45,077,185
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SOS1
SOS Ras/Rac guanine nucleotide exchange factor 1
affects expression
EXP
Diclofenac affects the expression of SOS1 mRNA
CTD
PMID:24752500
NCBI chr 2:38,981,549...39,124,868
Ensembl chr 2:38,962,206...39,124,345
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SOS2
SOS Ras/Rho guanine nucleotide exchange factor 2
affects expression
EXP
Diclofenac affects the expression of SOS2 mRNA
CTD
PMID:24752500
NCBI chr14:50,117,130...50,231,882
Ensembl chr14:50,117,130...50,231,578
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SPACA6
sperm acrosome associated 6
increases expression
ISO
Diclofenac results in increased expression of SPACA6 mRNA
CTD
PMID:30723492
NCBI chr19:51,682,686...51,713,143
Ensembl chr19:51,688,346...51,712,387
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SPDL1
spindle apparatus coiled-coil protein 1
decreases expression
ISO
Diclofenac results in decreased expression of SPDL1 mRNA
CTD
PMID:35537566
NCBI chr 5:169,583,773...169,604,778
Ensembl chr 5:169,583,636...169,604,778
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SPRY3
sprouty RTK signaling antagonist 3
increases expression
ISO
Diclofenac results in increased expression of SPRY3 mRNA
CTD
PMID:30723492
NCBI chr X:155,612,586...155,782,459 NCBI chr Y:56,923,423...56,968,979
Ensembl chr X:155,612,572...155,782,459
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SPRY4
sprouty RTK signaling antagonist 4
decreases expression
ISO
Diclofenac results in decreased expression of SPRY4 mRNA
CTD
PMID:26934552
NCBI chr 5:142,310,430...142,325,021
Ensembl chr 5:142,310,427...142,326,455
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SQLE
squalene epoxidase
increases expression
ISO
Diclofenac results in increased expression of SQLE mRNA
CTD
PMID:26934552
NCBI chr 8:124,998,505...125,022,283
Ensembl chr 8:124,998,497...125,022,283
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SRC
SRC proto-oncogene, non-receptor tyrosine kinase
affects expression
EXP
Diclofenac affects the expression of SRC mRNA
CTD
PMID:24752500
NCBI chr20:37,344,699...37,406,050
Ensembl chr20:37,344,685...37,406,050
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SRD5A1
steroid 5 alpha-reductase 1
decreases expression
ISO
Diclofenac results in decreased expression of SRD5A1 mRNA
CTD
PMID:26934552
NCBI chr 5:6,633,440...6,674,386
Ensembl chr 5:6,633,290...6,676,539
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SREBF2
sterol regulatory element binding transcription factor 2
increases expression
ISO
Diclofenac results in increased expression of SREBF2 mRNA
CTD
PMID:26934552
NCBI chr22:41,833,105...41,907,305
Ensembl chr22:41,833,105...41,907,306
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SRXN1
sulfiredoxin 1
increases expression multiple interactions
EXP ISO
Diclofenac results in increased expression of SRXN1 mRNA Diclofenac results in increased expression of SRXN1 protein NFE2L2 protein affects the reaction [Diclofenac results in increased expression of SRXN1 mRNA]
CTD
PMID:24752500 PMID:27358234
NCBI chr20:646,615...653,200
Ensembl chr20:646,615...653,200
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ST6GAL1
ST6 beta-galactoside alpha-2,6-sialyltransferase 1
increases expression
ISO
Diclofenac results in increased expression of ST6GAL1 mRNA
CTD
PMID:26934552
NCBI chr 3:186,930,526...187,078,553
Ensembl chr 3:186,930,325...187,078,553
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STAT1
signal transducer and activator of transcription 1
decreases expression multiple interactions affects expression
ISO EXP
Diclofenac results in decreased expression of STAT1 mRNA 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein]; 2-aminoethoxydiphenyl borate inhibits the reaction [[Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein]; [Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein; Calcium promotes the reaction [[Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein]; pyrazolanthrone inhibits the reaction [[Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein] Diclofenac affects the expression of STAT1 mRNA
CTD
PMID:19192274 PMID:22285467 PMID:24752500 PMID:26609140
NCBI chr 2:190,969,149...191,014,171
Ensembl chr 2:190,908,460...191,020,960
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STAT3
signal transducer and activator of transcription 3
increases expression affects expression
ISO EXP
Diclofenac results in increased expression of STAT3 mRNA Diclofenac affects the expression of STAT3 mRNA
CTD
PMID:22285467 PMID:23506792 PMID:24752500 PMID:26934552
NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568
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STAT4
signal transducer and activator of transcription 4
decreases expression
EXP
Diclofenac results in decreased expression of STAT4 mRNA
CTD
PMID:19192274
NCBI chr 2:191,029,576...191,151,596
Ensembl chr 2:191,029,576...191,178,435
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STAT5B
signal transducer and activator of transcription 5B
affects expression
EXP
Diclofenac affects the expression of STAT5B mRNA
CTD
PMID:24752500
NCBI chr17:42,199,177...42,288,370
Ensembl chr17:42,199,176...42,288,633
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STAT6
signal transducer and activator of transcription 6
affects expression
EXP
Diclofenac affects the expression of STAT6 mRNA
CTD
PMID:24752500
NCBI chr12:57,095,408...57,111,362
Ensembl chr12:57,095,408...57,132,139
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STEAP4
STEAP4 metalloreductase
increases expression decreases expression
ISO
Diclofenac results in increased expression of STEAP4 mRNA Diclofenac results in decreased expression of STEAP4 mRNA
CTD
PMID:26934552
NCBI chr 7:88,270,892...88,306,894
Ensembl chr 7:88,270,892...88,306,894
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STIL
STIL centriolar assembly protein
increases expression
ISO
Diclofenac results in increased expression of STIL mRNA
CTD
PMID:30723492
NCBI chr 1:47,250,139...47,314,896
Ensembl chr 1:47,250,139...47,314,892
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STK31
serine/threonine kinase 31
decreases expression
ISO
Diclofenac results in decreased expression of STK31 mRNA
CTD
PMID:26934552
NCBI chr 7:23,710,082...23,832,513
Ensembl chr 7:23,710,203...23,832,513
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STMN1
stathmin 1
affects expression
EXP
Diclofenac affects the expression of STMN1 mRNA
CTD
PMID:24752500
NCBI chr 1:25,884,179...25,906,880
Ensembl chr 1:25,884,181...25,906,991
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STS
steroid sulfatase
increases expression
EXP
Diclofenac results in increased expression of STS mRNA
CTD
PMID:19192274
NCBI chr X:7,147,290...7,354,641
Ensembl chr X:7,147,237...7,804,358
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SUCNR1
succinate receptor 1
decreases expression
ISO
Diclofenac results in decreased expression of SUCNR1 mRNA
CTD
PMID:26934552
NCBI chr 3:151,873,643...151,884,619
Ensembl chr 3:151,873,643...151,884,619
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SUV39H1
SUV39H1 histone lysine methyltransferase
affects expression
EXP
Diclofenac affects the expression of SUV39H1 mRNA
CTD
PMID:24752500
NCBI chr X:48,695,554...48,709,016
Ensembl chr X:48,695,554...48,709,016
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SYNE1
spectrin repeat containing nuclear envelope protein 1
decreases expression
ISO
Diclofenac results in decreased expression of SYNE1 mRNA
CTD
PMID:35537566
NCBI chr 6:152,121,687...152,637,362
Ensembl chr 6:152,121,687...152,637,801
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SYNE4
spectrin repeat containing nuclear envelope family member 4
increases expression
ISO
Diclofenac results in increased expression of SYNE4 mRNA
CTD
PMID:30723492
NCBI chr19:36,003,307...36,008,813
Ensembl chr19:36,003,307...36,008,813
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TAF3
TATA-box binding protein associated factor 3
affects expression
EXP
Diclofenac affects the expression of TAF3 mRNA
CTD
PMID:24752500
NCBI chr10:7,818,505...8,016,631
Ensembl chr10:7,818,497...8,016,631
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TAF9B
TATA-box binding protein associated factor 9b
affects expression
EXP
Diclofenac affects the expression of TAF9B mRNA
CTD
PMID:24752500
NCBI chr X:78,129,748...78,139,650
Ensembl chr X:78,129,748...78,139,650
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TANK
TRAF family member associated NFKB activator
affects expression
EXP
Diclofenac affects the expression of TANK mRNA
CTD
PMID:24752500
NCBI chr 2:161,136,963...161,236,230
Ensembl chr 2:161,136,908...161,236,230
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TARDBP
TAR DNA binding protein
decreases expression
ISO
Diclofenac results in decreased expression of TARDBP mRNA
CTD
PMID:26934552
NCBI chr 1:11,012,654...11,030,528
Ensembl chr 1:11,012,344...11,030,528
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TAS1R3
taste 1 receptor member 3
increases expression
ISO
Diclofenac results in increased expression of TAS1R3 mRNA
CTD
PMID:30723492
NCBI chr 1:1,331,280...1,335,314
Ensembl chr 1:1,331,280...1,335,314
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TASOR
transcription activation suppressor
affects expression
EXP
Diclofenac affects the expression of TASOR mRNA
CTD
PMID:24752500
NCBI chr 3:56,620,132...56,683,265
Ensembl chr 3:56,620,132...56,683,265
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TBC1D31
TBC1 domain family member 31
decreases expression
ISO
Diclofenac results in decreased expression of TBC1D31 mRNA
CTD
PMID:35537566
NCBI chr 8:123,072,707...123,165,173
Ensembl chr 8:123,041,968...123,152,153
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TBX21
T-box transcription factor 21
decreases expression
ISO
Diclofenac results in decreased expression of TBX21 mRNA
CTD
PMID:22285467
NCBI chr17:47,733,236...47,746,122
Ensembl chr17:47,733,236...47,746,122
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TBX3
T-box transcription factor 3
increases expression
ISO
Diclofenac results in increased expression of TBX3 mRNA
CTD
PMID:26934552
NCBI chr12:114,670,255...114,684,175
Ensembl chr12:114,670,255...114,684,175
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TCF3
transcription factor 3
affects expression
EXP
Diclofenac affects the expression of TCF3 mRNA
CTD
PMID:24752500
NCBI chr19:1,609,292...1,652,615
Ensembl chr19:1,609,291...1,652,615
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TCF7L2
transcription factor 7 like 2
affects expression
EXP
Diclofenac affects the expression of TCF7L2 mRNA
CTD
PMID:24752500
NCBI chr10:112,950,247...113,167,678
Ensembl chr10:112,950,247...113,167,678
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TDRD7
tudor domain containing 7
affects expression
EXP
Diclofenac affects the expression of TDRD7 mRNA
CTD
PMID:24752500
NCBI chr 9:97,412,096...97,496,125
Ensembl chr 9:97,412,096...97,496,125
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TECPR1
tectonin beta-propeller repeat containing 1
decreases expression
ISO
Diclofenac results in decreased expression of TECPR1 mRNA
CTD
PMID:35537566
NCBI chr 7:98,214,624...98,252,232
Ensembl chr 7:98,214,624...98,252,232
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TFDP1
transcription factor Dp-1
affects expression
EXP
Diclofenac affects the expression of TFDP1 mRNA
CTD
PMID:24752500
NCBI chr13:113,584,688...113,641,473
Ensembl chr13:113,584,721...113,641,473
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TFF3
trefoil factor 3
increases expression
ISO
Diclofenac results in increased expression of TFF3 mRNA
CTD
PMID:26934552
NCBI chr21:42,311,667...42,315,409
Ensembl chr21:42,311,667...42,315,409
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TFRC
transferrin receptor
increases expression
ISO
Diclofenac results in increased expression of TFRC mRNA
CTD
PMID:26934552
NCBI chr 3:196,049,284...196,082,090
Ensembl chr 3:196,012,511...196,082,153
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TGFA
transforming growth factor alpha
increases expression
EXP
Diclofenac results in increased expression of TGFA mRNA
CTD
PMID:19022234
NCBI chr 2:70,447,284...70,553,826
Ensembl chr 2:70,447,284...70,554,193
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TGFB2
transforming growth factor beta 2
decreases expression
EXP
Diclofenac results in decreased expression of TGFB2 mRNA
CTD
PMID:17379860
NCBI chr 1:218,345,336...218,444,619
Ensembl chr 1:218,345,336...218,444,619
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TGM1
transglutaminase 1
increases expression
ISO
Diclofenac results in increased expression of TGM1 mRNA
CTD
PMID:26934552
NCBI chr14:24,249,114...24,263,177
Ensembl chr14:24,249,114...24,264,432
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TIFA
TRAF interacting protein with forkhead associated domain
increases expression
ISO
Diclofenac results in increased expression of TIFA mRNA
CTD
PMID:26934552
NCBI chr 4:112,274,537...112,285,904
Ensembl chr 4:112,272,968...112,285,955
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TIMP1
TIMP metallopeptidase inhibitor 1
decreases expression increases expression
ISO
Diclofenac results in decreased expression of TIMP1 mRNA Diclofenac results in increased expression of TIMP1 mRNA
CTD
PMID:19022234 PMID:26934552
NCBI chr X:47,582,436...47,586,789
Ensembl chr X:47,582,408...47,586,789
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TIRAP
TIR domain containing adaptor protein
increases expression
ISO
Diclofenac results in increased expression of TIRAP mRNA
CTD
PMID:26934552
NCBI chr11:126,283,093...126,294,933
Ensembl chr11:126,282,497...126,298,845
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TJP1
tight junction protein 1
affects expression
EXP
Diclofenac affects the expression of TJP1 mRNA
CTD
PMID:24752500
NCBI chr15:29,699,367...29,969,049
Ensembl chr15:29,699,367...29,968,915
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TK1
thymidine kinase 1
affects expression
EXP
Diclofenac affects the expression of TK1 mRNA
CTD
PMID:24752500
NCBI chr17:78,174,079...78,187,204
Ensembl chr17:78,174,091...78,187,233
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TK2
thymidine kinase 2
affects expression
EXP
Diclofenac affects the expression of TK2 mRNA
CTD
PMID:24752500
NCBI chr16:66,508,003...66,550,291
Ensembl chr16:66,508,003...66,552,544
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TLCD1
TLC domain containing 1
increases expression
ISO
Diclofenac results in increased expression of TLCD1 mRNA
CTD
PMID:35537566
NCBI chr17:28,724,348...28,727,937
Ensembl chr17:28,724,348...28,727,935
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TLK1
tousled like kinase 1
decreases expression
ISO
Diclofenac results in decreased expression of TLK1 mRNA
CTD
PMID:26934552
NCBI chr 2:170,990,823...171,231,293
Ensembl chr 2:170,990,823...171,231,314
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TLR2
toll like receptor 2
decreases expression increases expression
EXP ISO
Diclofenac results in decreased expression of TLR2 mRNA Diclofenac results in increased expression of TLR2 mRNA
CTD
PMID:19192274 PMID:26934552 PMID:29027214
NCBI chr 4:153,684,280...153,710,637
Ensembl chr 4:153,684,050...153,706,260
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TM7SF2
transmembrane 7 superfamily member 2
increases expression
ISO
Diclofenac results in increased expression of TM7SF2 mRNA
CTD
PMID:35537566
NCBI chr11:65,111,872...65,116,230
Ensembl chr11:65,111,845...65,116,384
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TMEM176A
transmembrane protein 176A
increases expression decreases expression
ISO
Diclofenac results in increased expression of TMEM176A mRNA Diclofenac results in decreased expression of TMEM176A mRNA
CTD
PMID:26934552
NCBI chr 7:150,800,769...150,805,118
Ensembl chr 7:150,800,403...150,805,118
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TMPRSS2
transmembrane serine protease 2
increases expression
EXP
Diclofenac results in increased expression of TMPRSS2 mRNA
CTD
PMID:32808185
NCBI chr21:41,464,305...41,508,158
Ensembl chr21:41,464,300...41,531,116
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TNC
tenascin C
decreases expression
ISO
Diclofenac results in decreased expression of TNC mRNA
CTD
PMID:35537566
NCBI chr 9:115,019,575...115,118,157
Ensembl chr 9:115,019,575...115,118,207
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TNF
tumor necrosis factor
increases expression multiple interactions increases response to substance
EXP ISO
Diclofenac results in increased expression of TNF mRNA 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [TNF protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 2-aminoethoxydiphenyl borate inhibits the reaction [[TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 2-aminoethoxydiphenyl borate inhibits the reaction [TNF protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Diclofenac; [TNF protein co-treated with Diclofenac] results in increased activity of CASP8 protein; [TNF protein co-treated with Diclofenac] results in increased activity of CASP9 protein; [TNF protein co-treated with Diclofenac] results in increased phosphorylation of EIF2S1 protein; [TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac affects the abundance of Calcium]; [TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP9 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP8 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP9 protein]; Diclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of TNF protein]; Diclofenac inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Diclofenac inhibits the reaction [TNF protein results in increased activity of CHUK protein]; Diclofenac inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Diclofenac inhibits the reaction [TNF protein results in increased activity of RELA protein]; Diclofenac inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Diclofenac inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; Diclofenac inhibits the reaction [TNF protein results in increased expression of CRP mRNA]; Diclofenac inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; Diclofenac inhibits the reaction [TNF protein results in increased expression of ITGB3 protein]; Diclofenac inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; Diclofenac inhibits the reaction [TNF protein results in increased secretion of CRP protein]; Diclofenac inhibits the reaction [TNF protein results in increased secretion of CXCL8 protein]; Diclofenac promotes the reaction [Mustard Gas results in increased secretion of TNF protein]; TNF protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein] TNF protein results in increased susceptibility to Diclofenac Diclofenac results in increased expression of TNF mRNA; Diclofenac results in increased expression of TNF protein 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; [Water deficiency co-treated with Diclofenac] results in increased expression of TNF protein; Acetylcysteine inhibits the reaction [Diclofenac results in increased expression of TNF mRNA]; Acetylcysteine inhibits the reaction [Diclofenac results in increased expression of TNF protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of TNF protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in decreased expression of NFKBIA protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in increased expression of TNF protein]; RELA mutant form inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; Silymarin inhibits the reaction [Diclofenac results in increased expression of TNF mRNA]; Silymarin inhibits the reaction [Diclofenac results in increased expression of TNF protein]; SN50 peptide inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]] [Diclofenac co-treated with Lipopolysaccharides] results in increased secretion of TNF protein; Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of TNF protein]
CTD
PMID:15135310 PMID:15489888 PMID:17328244 PMID:19022234 PMID:19362101 PMID:19393675 PMID:19691487 PMID:22285467 PMID:23395999 PMID:23939143 PMID:25450234 PMID:25935278 PMID:26609140 PMID:27313093 PMID:28535741 PMID:29027214 PMID:29777833 PMID:31042592 PMID:31048000 PMID:31926916 PMID:35537566 More...
NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
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TNFAIP3
TNF alpha induced protein 3
decreases expression
EXP
Diclofenac results in decreased expression of TNFAIP3 mRNA
CTD
PMID:21873647
NCBI chr 6:137,866,349...137,883,312
Ensembl chr 6:137,867,214...137,883,314
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TNFAIP8L2
TNF alpha induced protein 8 like 2
increases expression
ISO
Diclofenac results in increased expression of TNFAIP8L2 mRNA
CTD
PMID:26934552
NCBI chr 1:151,156,649...151,159,749
Ensembl chr 1:151,156,649...151,159,749
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TNFRSF10A
TNF receptor superfamily member 10a
increases expression
ISO
Diclofenac results in increased expression of TNFRSF10B mRNA
CTD
PMID:35537566
NCBI chr 8:23,190,452...23,225,102
Ensembl chr 8:23,190,452...23,225,102
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TNFRSF10B
TNF receptor superfamily member 10b
affects expression
EXP
Diclofenac affects the expression of TNFRSF10B mRNA
CTD
PMID:24752500
NCBI chr 8:23,020,133...23,069,031
Ensembl chr 8:23,020,133...23,069,031
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TNFRSF1A
TNF receptor superfamily member 1A
affects expression increases expression
EXP ISO
Diclofenac affects the expression of TNFRSF1A mRNA Diclofenac results in increased expression of TNFRSF1A mRNA
CTD
PMID:24752500 PMID:26934552
NCBI chr12:6,328,771...6,342,076
Ensembl chr12:6,328,757...6,342,114
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TNFSF18
TNF superfamily member 18
decreases expression
ISO
Diclofenac results in decreased expression of TNFSF18 mRNA
CTD
PMID:35537566
NCBI chr 1:173,039,202...173,050,941
Ensembl chr 1:173,039,202...173,050,941
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TNKS1BP1
tankyrase 1 binding protein 1
decreases expression
ISO
Diclofenac results in decreased expression of TNKS1BP1 mRNA
CTD
PMID:35537566
NCBI chr11:57,299,642...57,324,952
Ensembl chr11:57,299,638...57,324,952
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TOGARAM2
TOG array regulator of axonemal microtubules 2
increases expression
ISO
Diclofenac results in increased expression of TOGARAM2 mRNA
CTD
PMID:30723492
NCBI chr 2:28,956,518...29,052,230
Ensembl chr 2:28,956,611...29,052,230
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TOX
thymocyte selection associated high mobility group box
increases expression
ISO
Diclofenac results in increased expression of TOX mRNA
CTD
PMID:30723492
NCBI chr 8:58,805,412...59,119,147
Ensembl chr 8:58,805,412...59,119,147
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TP53
tumor protein p53
multiple interactions affects expression increases expression
ISO EXP
Diclofenac promotes the reaction [Doxorubicin results in increased expression of TRP53 protein] Diclofenac affects the expression of TP53 mRNA Diclofenac results in increased expression of TP53 mRNA; Diclofenac results in increased expression of TP53 protein
CTD
PMID:15458769 PMID:24752500 PMID:29027214 PMID:32087850
NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,546
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TP53INP1
tumor protein p53 inducible nuclear protein 1
increases expression
ISO
Diclofenac results in increased expression of TRP53INP1 mRNA
CTD
PMID:26934552 PMID:35537566
NCBI chr 8:94,925,972...94,949,378
Ensembl chr 8:94,925,972...94,949,378
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TPD52
tumor protein D52
increases expression
EXP
Diclofenac results in increased expression of TPD52 mRNA
CTD
PMID:21873647
NCBI chr 8:80,031,082...80,171,564
Ensembl chr 8:80,034,745...80,231,232
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TPSB2
tryptase beta 2
increases expression
ISO
Diclofenac results in increased expression of TPSB2 mRNA
CTD
PMID:30723492
NCBI chr16:1,228,336...1,230,184
Ensembl chr16:1,227,272...1,232,757
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TRAF3IP3
TRAF3 interacting protein 3
increases expression
ISO
Diclofenac results in increased expression of TRAF3IP3 mRNA
CTD
PMID:30723492
NCBI chr 1:209,756,053...209,782,310
Ensembl chr 1:209,756,032...209,782,320
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TRAT1
T cell receptor associated transmembrane adaptor 1
increases expression
ISO
Diclofenac results in increased expression of TRAT1 mRNA
CTD
PMID:26934552
NCBI chr 3:108,822,786...108,855,005
Ensembl chr 3:108,822,770...108,855,005
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TRIB3
tribbles pseudokinase 3
decreases expression
ISO
Diclofenac results in decreased expression of TRIB3 mRNA
CTD
PMID:26934552 PMID:35537566
NCBI chr20:380,760...397,559
Ensembl chr20:362,835...397,559
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TRIM46
tripartite motif containing 46
decreases expression
ISO
Diclofenac results in decreased expression of TRIM46 mRNA
CTD
PMID:35537566
NCBI chr 1:155,173,849...155,184,971
Ensembl chr 1:155,173,787...155,184,971
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TSC1
TSC complex subunit 1
affects expression
EXP
Diclofenac affects the expression of TSC1 mRNA
CTD
PMID:24752500
NCBI chr 9:132,891,349...132,945,378
Ensembl chr 9:132,891,348...132,946,874
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TSC22D1
TSC22 domain family member 1
decreases expression
ISO
Diclofenac results in decreased expression of TSC22D1 mRNA
CTD
PMID:26934552
NCBI chr13:44,432,143...44,577,344
Ensembl chr13:44,432,143...44,577,147
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TSC22D2
TSC22 domain family member 2
increases expression
ISO
Diclofenac results in increased expression of TSC22D2 mRNA
CTD
PMID:26934552
NCBI chr 3:150,408,298...150,466,422
Ensembl chr 3:150,408,298...150,466,422
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TSC22D3
TSC22 domain family member 3
increases expression decreases expression
ISO
Diclofenac results in increased expression of TSC22D3 mRNA Diclofenac results in decreased expression of TSC22D3 mRNA
CTD
PMID:26934552 PMID:35537566
NCBI chr X:107,713,221...107,775,988
Ensembl chr X:107,713,221...107,777,342
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TSKS
testis specific serine kinase substrate
increases expression
ISO
Diclofenac results in increased expression of TSKS mRNA
CTD
PMID:30723492
NCBI chr19:49,739,760...49,763,306
Ensembl chr19:49,739,753...49,763,306
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TSPAN4
tetraspanin 4
increases expression
ISO
Diclofenac results in increased expression of TSPAN4 mRNA
CTD
PMID:26934552
NCBI chr11:842,852...867,111
Ensembl chr11:842,812...867,116
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TSPAN8
tetraspanin 8
increases expression
ISO
Diclofenac results in increased expression of TSPAN8 mRNA
CTD
PMID:26934552
NCBI chr12:71,125,096...71,157,999
Ensembl chr12:71,125,085...71,441,898
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TSPEAR
thrombospondin type laminin G domain and EAR repeats
increases expression
ISO
Diclofenac results in increased expression of TSPEAR mRNA
CTD
PMID:30723492
NCBI chr21:44,497,893...44,711,572
Ensembl chr21:44,497,893...44,711,572
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TTR
transthyretin
increases expression
ISO
Diclofenac results in increased expression of TTR protein
CTD
PMID:23506792
NCBI chr18:31,591,877...31,598,821
Ensembl chr18:31,557,009...31,598,833
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TUBA1A
tubulin alpha 1a
affects expression
EXP
Diclofenac affects the expression of TUBA1A mRNA
CTD
PMID:24752500
NCBI chr12:49,184,795...49,189,080
Ensembl chr12:49,184,686...49,189,324
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TUBA1C
tubulin alpha 1c
affects expression
EXP
Diclofenac affects the expression of TUBA1C mRNA
CTD
PMID:24752500
NCBI chr12:49,227,926...49,274,600
Ensembl chr12:49,188,736...49,274,600
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TUBA3C
tubulin alpha 3c
affects expression
EXP
Diclofenac affects the expression of TUBA3C mRNA
CTD
PMID:24752500
NCBI chr13:19,173,772...19,181,824
Ensembl chr13:19,173,772...19,181,824
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TUBB3
tubulin beta 3 class III
affects expression
EXP
Diclofenac affects the expression of TUBB3 mRNA
CTD
PMID:24752500
NCBI chr16:89,921,925...89,936,097
Ensembl chr16:89,921,392...89,938,761
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TUBB4B
tubulin beta 4B class IVb
affects expression
EXP
Diclofenac affects the expression of TUBB4B mRNA
CTD
PMID:24752500
NCBI chr 9:137,241,287...137,243,707
Ensembl chr 9:137,241,287...137,243,707
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TXN
thioredoxin
increases expression multiple interactions
EXP ISO
Diclofenac results in increased expression of TXN mRNA [Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of TXN1 protein; Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TXN1 mRNA]; Diclofenac inhibits the reaction [Poly I-C results in increased expression of TXN1 mRNA]
CTD
PMID:19022234 PMID:23939143 PMID:25772430
NCBI chr 9:110,243,810...110,256,507
Ensembl chr 9:110,243,810...110,256,507
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TXN2
thioredoxin 2
increases expression
ISO
Diclofenac results in increased expression of TXN2 mRNA
CTD
PMID:19022234
NCBI chr22:36,467,046...36,481,640
Ensembl chr22:36,467,046...36,481,640
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TXNIP
thioredoxin interacting protein
increases expression
EXP
Diclofenac results in increased expression of TXNIP mRNA
CTD
PMID:19192274
NCBI chr 1:145,992,435...145,996,579
Ensembl chr 1:145,992,435...145,996,579
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TXNRD1
thioredoxin reductase 1
affects expression multiple interactions
EXP ISO
Diclofenac affects the expression of TXNRD1 mRNA [Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of TXNRD1 protein
CTD
PMID:24752500 PMID:25772430
NCBI chr12:104,215,779...104,350,307
Ensembl chr12:104,215,779...104,350,307
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TYR
tyrosinase
decreases expression
ISO
Diclofenac results in decreased expression of TYR protein
CTD
PMID:21079976
NCBI chr11:89,177,875...89,295,759
Ensembl chr11:89,177,875...89,295,759
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TYROBP
transmembrane immune signaling adaptor TYROBP
increases expression
ISO
Diclofenac results in increased expression of TYROBP mRNA
CTD
PMID:26934552
NCBI chr19:35,904,403...35,908,295
Ensembl chr19:35,904,401...35,908,295
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UBC
ubiquitin C
affects expression
ISO
Diclofenac affects the expression of UBC mRNA
CTD
PMID:26934552
NCBI chr12:124,911,646...124,914,650
Ensembl chr12:124,911,604...124,917,368
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UCK2
uridine-cytidine kinase 2
affects expression
EXP
Diclofenac affects the expression of UCK2 mRNA
CTD
PMID:24752500
NCBI chr 1:165,827,614...165,911,618
Ensembl chr 1:165,827,614...165,911,618
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UCP2
uncoupling protein 2
increases expression
ISO
Diclofenac results in increased expression of UCP2 mRNA
CTD
PMID:26934552
NCBI chr11:73,974,672...73,983,202
Ensembl chr11:73,974,672...73,982,843
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UGT1A1
UDP glucuronosyltransferase family 1 member A1
increases expression multiple interactions decreases expression decreases activity
EXP ISO
Diclofenac results in increased expression of UGT1A1 mRNA Diclofenac inhibits the reaction [[UGT1A1 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Diclofenac inhibits the reaction [UGT1A1 protein results in increased glucuronidation of Hymecromone] Diclofenac results in decreased expression of UGT1A1 mRNA Diclofenac results in decreased activity of UGT1A1 protein
CTD
PMID:15334623 PMID:15593333 PMID:18227147 PMID:19022234 PMID:33290829
NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300
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UGT1A10
UDP glucuronosyltransferase family 1 member A10
affects expression increases glucuronidation
EXP
Diclofenac affects the expression of UGT1A10 mRNA UGT1A10 protein results in increased glucuronidation of Diclofenac
CTD
PMID:15117964 PMID:19022234 PMID:22265884
NCBI chr 2:233,636,448...233,773,300
Ensembl chr 2:233,636,448...233,773,300
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UGT1A3
UDP glucuronosyltransferase family 1 member A3
decreases activity increases glucuronidation
EXP
Diclofenac results in decreased activity of UGT1A3 protein UGT1A3 protein results in increased glucuronidation of Diclofenac
CTD
PMID:15117964 PMID:15334623 PMID:15843492
NCBI chr 2:233,729,042...233,773,300
Ensembl chr 2:233,729,042...233,773,300
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UGT1A4
UDP glucuronosyltransferase family 1 member A4
increases glucuronidation
EXP
UGT1A4 protein results in increased glucuronidation of Diclofenac
CTD
PMID:15843492
NCBI chr 2:233,718,736...233,773,300
Ensembl chr 2:233,718,736...233,773,300
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UGT1A6
UDP glucuronosyltransferase family 1 member A6
multiple interactions
EXP
Diclofenac inhibits the reaction [[UGT1A6 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Diclofenac inhibits the reaction [UGT1A6 protein results in increased glucuronidation of 1-naphthol]; Diclofenac inhibits the reaction [UGT1A6 protein results in increased glucuronidation of Hymecromone]
CTD
PMID:22265884 PMID:33290829
NCBI chr 2:233,691,702...233,773,300
Ensembl chr 2:233,691,607...233,773,300
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UGT1A7
UDP glucuronosyltransferase family 1 member A7
increases glucuronidation multiple interactions
EXP
UGT1A7 protein results in increased glucuronidation of Diclofenac Diclofenac inhibits the reaction [[UGT1A7 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Diclofenac inhibits the reaction [UGT1A7 protein results in increased glucuronidation of Hymecromone]
CTD
PMID:15117964 PMID:33290829
NCBI chr 2:233,681,901...233,773,300
Ensembl chr 2:233,681,901...233,773,300
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UGT1A8
UDP glucuronosyltransferase family 1 member A8
increases glucuronidation
EXP
UGT1A8 protein results in increased glucuronidation of Diclofenac
CTD
PMID:15117964
NCBI chr 2:233,617,633...233,773,300
Ensembl chr 2:233,617,633...233,773,300
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UGT1A9
UDP glucuronosyltransferase family 1 member A9
increases glucuronidation multiple interactions
EXP
UGT1A9 protein results in increased glucuronidation of Diclofenac Diclofenac inhibits the reaction [[UGT1A9 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Diclofenac inhibits the reaction [UGT1A9 protein results in increased glucuronidation of Hymecromone]
CTD
PMID:15988124 PMID:33290829
NCBI chr 2:233,671,898...233,773,300
Ensembl chr 2:233,671,898...233,773,300
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UGT2B15
UDP glucuronosyltransferase family 2 member B15
decreases activity increases glucuronidation
EXP
Diclofenac results in decreased activity of UGT2B15 protein UGT2B15 protein results in increased glucuronidation of Diclofenac
CTD
PMID:15334623 PMID:15843492
NCBI chr 4:68,646,597...68,670,652
Ensembl chr 4:68,646,597...68,670,652
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UGT2B17
UDP glucuronosyltransferase family 2 member B17
increases glucuronidation
EXP
UGT2B17 protein results in increased glucuronidation of Diclofenac
CTD
PMID:15843492 PMID:22265884
NCBI chr 4:68,537,173...68,576,322
Ensembl chr 4:68,537,173...68,576,413
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UGT2B7
UDP glucuronosyltransferase family 2 member B7
multiple interactions affects glucuronidation affects response to substance increases metabolic processing increases glucuronidation
EXP
[CYP3A4 protein co-treated with CYP2C9 protein co-treated with UGT2B7 protein] results in increased susceptibility to Diclofenac; [UGT2B7 protein polymorphism affects the glucuronidation of Diclofenac] which affects the chemical synthesis of 1-O-(2-((2',6'-dichlorophenyl)amino)phenylacetyl)glucopyranuronic acid; Diclofenac inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; Diclofenac inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]; Diclofenac inhibits the reaction [UGT2B7 protein results in increased glucuronidation of denopamine] UGT2B7 protein polymorphism affects the susceptibility to Diclofenac UGT2B7 protein results in increased metabolism of Diclofenac UGT2B7 protein results in increased glucuronidation of Diclofenac
CTD
PMID:15608137 PMID:15843492 PMID:15988124 PMID:19740398 PMID:22265884 PMID:24104198 PMID:24552538 PMID:28500425 PMID:28762043 PMID:29203276 More...
NCBI chr 4:69,051,375...69,112,987
Ensembl chr 4:69,051,363...69,112,987
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ULK2
unc-51 like autophagy activating kinase 2
increases expression
ISO
Diclofenac results in increased expression of ULK2 mRNA
CTD
PMID:26934552
NCBI chr17:19,770,830...19,867,936
Ensembl chr17:19,770,829...19,867,936
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UNG
uracil DNA glycosylase
affects expression increases expression
EXP ISO
Diclofenac affects the expression of UNG mRNA Diclofenac results in increased expression of UNG mRNA
CTD
PMID:24752500 PMID:26934552
NCBI chr12:109,097,597...109,110,992
Ensembl chr12:109,097,597...109,126,725
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UPP2
uridine phosphorylase 2
decreases expression
ISO
Diclofenac results in decreased expression of UPP2 mRNA
CTD
PMID:26934552
NCBI chr 2:157,995,179...158,136,154
Ensembl chr 2:157,876,679...158,136,154
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USP28
ubiquitin specific peptidase 28
increases expression
ISO
Diclofenac results in increased expression of USP28 mRNA
CTD
PMID:26934552
NCBI chr11:113,797,875...113,875,572
Ensembl chr11:113,797,874...113,875,572
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VCAM1
vascular cell adhesion molecule 1
increases expression
ISO
Diclofenac results in increased expression of VCAM1 mRNA
CTD
PMID:26934552
NCBI chr 1:100,719,742...100,739,045
Ensembl chr 1:100,719,742...100,739,045
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VCAN
versican
decreases expression
ISO
Diclofenac results in decreased expression of VCAN mRNA
CTD
PMID:26934552
NCBI chr 5:83,471,744...83,582,302
Ensembl chr 5:83,471,618...83,582,303
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VCL
vinculin
affects expression
EXP
Diclofenac affects the expression of VCL mRNA
CTD
PMID:24752500
NCBI chr10:73,998,116...74,121,363
Ensembl chr10:73,995,193...74,121,363
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VEGFA
vascular endothelial growth factor A
affects expression
EXP
Diclofenac affects the expression of VEGFA mRNA
CTD
PMID:24752500
NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487
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VEGFC
vascular endothelial growth factor C
decreases expression
ISO
Diclofenac results in decreased expression of VEGFC mRNA
CTD
PMID:35537566
NCBI chr 4:176,683,538...176,792,922
Ensembl chr 4:176,683,538...176,792,922
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VIM
vimentin
decreases expression
EXP
Diclofenac results in decreased expression of VIM protein
CTD
PMID:19628293
NCBI chr10:17,228,241...17,237,593
Ensembl chr10:17,228,241...17,237,593
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VLDLR
very low density lipoprotein receptor
decreases expression
ISO
Diclofenac results in decreased expression of VLDLR mRNA
CTD
PMID:26934552
NCBI chr 9:2,621,787...2,660,056
Ensembl chr 9:2,621,182...2,660,056
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VSIG4
V-set and immunoglobulin domain containing 4
increases expression
ISO
Diclofenac results in increased expression of VSIG4 mRNA
CTD
PMID:26934552
NCBI chr X:66,021,738...66,040,080
Ensembl chr X:66,021,738...66,040,125
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VWCE
von Willebrand factor C and EGF domains
decreases expression
ISO
Diclofenac results in decreased expression of VWCE mRNA
CTD
PMID:26934552
NCBI chr11:61,258,286...61,295,316
Ensembl chr11:61,258,286...61,295,316
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WDR11
WD repeat domain 11
decreases expression
ISO
Diclofenac results in decreased expression of WDR11 mRNA
CTD
PMID:35537566
NCBI chr10:120,851,362...120,909,524
Ensembl chr10:120,851,305...120,909,524
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WIPI1
WD repeat domain, phosphoinositide interacting 1
increases expression
ISO
Diclofenac results in increased expression of WIPI1 mRNA
CTD
PMID:26934552
NCBI chr17:68,421,281...68,457,496
Ensembl chr17:68,420,948...68,457,513
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XBP1
X-box binding protein 1
increases expression
ISO
Diclofenac results in increased expression of XBP1 mRNA
CTD
PMID:26934552
NCBI chr22:28,794,560...28,800,569
Ensembl chr22:28,794,555...28,800,597
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XIAP
X-linked inhibitor of apoptosis
affects expression increases expression
EXP ISO
Diclofenac affects the expression of XIAP mRNA Diclofenac results in increased expression of XIAP mRNA
CTD
PMID:24752500 PMID:26934552
NCBI chr X:123,859,708...123,913,972
Ensembl chr X:123,859,712...123,913,972
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YWHAB
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
affects expression
EXP
Diclofenac affects the expression of YWHAB mRNA
CTD
PMID:24752500
NCBI chr20:44,885,705...44,908,532
Ensembl chr20:44,885,702...44,908,532
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YWHAQ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
affects expression
EXP
Diclofenac affects the expression of YWHAQ mRNA
CTD
PMID:24752500
NCBI chr 2:9,583,967...9,630,997
Ensembl chr 2:9,583,967...9,630,997
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ZBP1
Z-DNA binding protein 1
increases expression
ISO
Diclofenac results in increased expression of ZBP1 mRNA
CTD
PMID:26934552
NCBI chr20:57,603,852...57,620,426
Ensembl chr20:57,603,846...57,620,576
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ZDHHC23
zinc finger DHHC-type palmitoyltransferase 23
increases expression
ISO
Diclofenac results in increased expression of ZDHHC23 mRNA
CTD
PMID:35537566
NCBI chr 3:113,947,901...113,979,508
Ensembl chr 3:113,947,901...113,965,401
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ZEB1
zinc finger E-box binding homeobox 1
decreases expression
EXP
Diclofenac results in decreased expression of ZEB1 protein
CTD
PMID:19628293
NCBI chr10:31,318,417...31,529,804
Ensembl chr10:31,318,495...31,529,814
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ZNF346
zinc finger protein 346
decreases expression
ISO
Diclofenac results in decreased expression of ZFP346 mRNA
CTD
PMID:35537566
NCBI chr 5:177,022,696...177,081,189
Ensembl chr 5:177,022,696...177,081,189
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ZNF420
zinc finger protein 420
decreases expression
ISO
Diclofenac results in decreased expression of ZFP420 mRNA
CTD
PMID:35537566
NCBI chr19:37,007,902...37,130,368
Ensembl chr19:37,007,857...37,130,368
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ZNF786
zinc finger protein 786
increases expression
ISO
Diclofenac results in increased expression of ZFP786 mRNA
CTD
PMID:30723492
NCBI chr 7:149,069,641...149,090,718
Ensembl chr 7:149,069,641...149,090,782
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ZNRD2
zinc ribbon domain containing 2
increases expression
ISO
Diclofenac results in increased expression of ZNRD2 mRNA
CTD
PMID:35537566
NCBI chr11:65,570,477...65,571,888
Ensembl chr11:65,570,460...65,573,942
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AR
androgen receptor
multiple interactions
EXP
4'-hydroxydiclofenac binds to and affects the activity of AR protein
CTD
PMID:29777833
NCBI chr X:67,544,021...67,730,619
Ensembl chr X:67,544,021...67,730,619
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CCL2
C-C motif chemokine ligand 2
increases expression
EXP
4'-hydroxydiclofenac results in increased expression of CCL2 mRNA
CTD
PMID:24104198
NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208
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CXCL8
C-X-C motif chemokine ligand 8
increases expression
EXP
4'-hydroxydiclofenac results in increased expression of CXCL8 mRNA
CTD
PMID:24104198
NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716
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CYP2C9
cytochrome P450 family 2 subfamily C member 9
increases chemical synthesis multiple interactions
EXP
CYP2C9 protein results in increased chemical synthesis of 4'-hydroxydiclofenac [[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [[Ticrynafen results in decreased activity of CYP2C9 protein] which affects the metabolism of Diclofenac] which affects the abundance of 4'-hydroxydiclofenac; [CYP2C9 mRNA results in increased metabolism of Diclofenac] which results in increased chemical synthesis of 4'-hydroxydiclofenac; [CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac; [CYP2C9 protein results in increased hydroxylation of Diclofenac] which results in increased chemical synthesis of 4'-hydroxydiclofenac; [CYP2C9 protein results in increased metabolism of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [CYP2C9 protein results in increased metabolism of Diclofenac] which results in increased chemical synthesis of 4'-hydroxydiclofenac; Sulfaphenazole inhibits the reaction [[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac]
CTD
PMID:12401345 PMID:15155557 PMID:24104198 PMID:24246759 PMID:25084468 PMID:29555536 PMID:31854189 PMID:35366062 PMID:35748891 More...
NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091
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CYP2D6
cytochrome P450 family 2 subfamily D member 6
multiple interactions
EXP
[[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac
CTD
PMID:24246759
NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,865
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ESR1
estrogen receptor 1
affects activity
EXP
4'-hydroxydiclofenac affects the activity of ESR1 protein
CTD
PMID:29777833
NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619
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GSTP1
glutathione S-transferase pi 1
multiple interactions increases glutathionylation
EXP
[[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac; NQO1 protein inhibits the reaction [GSTP1 protein results in increased glutathionylation of 4'-hydroxydiclofenac]; Sulfaphenazole inhibits the reaction [[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac]
CTD
PMID:24246759 PMID:24552538
NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656
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IL10
interleukin 10
multiple interactions
EXP
4'-hydroxydiclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL10 protein]
CTD
PMID:29777833
NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
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IL2
interleukin 2
multiple interactions
EXP
4'-hydroxydiclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL2 protein]
CTD
PMID:29777833
NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725
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IL4
interleukin 4
multiple interactions
EXP
4'-hydroxydiclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL4 protein]
CTD
PMID:29777833
NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678
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IL6
interleukin 6
multiple interactions
EXP
4'-hydroxydiclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL6 protein]
CTD
PMID:29777833
NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002
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MPO
myeloperoxidase
multiple interactions
EXP
4'-hydroxydiclofenac promotes the reaction [[Hydrogen Peroxide co-treated with MPO protein co-treated with Glutathione] results in increased glutathionylation of 5,5-dimethyl-1-pyrroline-1-oxide]; 4'-hydroxydiclofenac promotes the reaction [Hydrogen Peroxide results in increased activity of MPO protein]; [Hydrogen Peroxide results in increased activity of MPO protein] which results in increased oxidation of and results in increased susceptibility to 4'-hydroxydiclofenac
CTD
PMID:28754375
NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935
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NQO1
NAD(P)H quinone dehydrogenase 1
multiple interactions
EXP
NQO1 protein inhibits the reaction [GSTP1 protein results in increased glutathionylation of 4'-hydroxydiclofenac]
CTD
PMID:24552538
NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
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NQO2
N-ribosyldihydronicotinamide:quinone dehydrogenase 2
multiple interactions
EXP
NQO2 protein results in increased reduction of and results in decreased glutathionylation of 4'-hydroxydiclofenac
CTD
PMID:29281794
NCBI chr 6:2,999,894...3,019,755
Ensembl chr 6:2,987,987...3,019,755
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NR3C1
nuclear receptor subfamily 3 group C member 1
multiple interactions
EXP
4'-hydroxydiclofenac binds to and affects the activity of NR3C1 protein
CTD
PMID:29777833
NCBI chr 5:143,277,931...143,435,512
Ensembl chr 5:143,277,931...143,435,512
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TNF
tumor necrosis factor
increases response to substance multiple interactions
ISO EXP
TNF protein results in increased susceptibility to 4'-hydroxydiclofenac 4'-hydroxydiclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of TNF protein]
CTD
PMID:23939143 PMID:29777833
NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
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CYP2B6
cytochrome P450 family 2 subfamily B member 6
multiple interactions
EXP
[CYP2B6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac
CTD
PMID:24246759
NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398
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CYP2C18
cytochrome P450 family 2 subfamily C member 18
multiple interactions
EXP
[CYP2C18 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac
CTD
PMID:24246759
NCBI chr10:94,683,729...94,736,190
Ensembl chr10:94,683,729...94,736,190
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CYP2C19
cytochrome P450 family 2 subfamily C member 19
multiple interactions
EXP
[CYP2C19 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac
CTD
PMID:24246759
NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547
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CYP2D6
cytochrome P450 family 2 subfamily D member 6
multiple interactions
EXP
[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac
CTD
PMID:24246759
NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,865
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CYP3A4
cytochrome P450 family 3 subfamily A member 4
multiple interactions
EXP
[[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 5-hydroxydiclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac]
CTD
PMID:24246759
NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
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CYP3A5
cytochrome P450 family 3 subfamily A member 5
multiple interactions
EXP
[CYP3A5 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac
CTD
PMID:24246759
NCBI chr 7:99,648,194...99,679,996
Ensembl chr 7:99,648,194...99,679,996
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GSTP1
glutathione S-transferase pi 1
multiple interactions
EXP
[[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 5-hydroxydiclofenac; [CYP2B6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP2C18 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP2C19 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP3A5 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac]
CTD
PMID:24246759
NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656
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MPO
myeloperoxidase
multiple interactions
EXP
[Hydrogen Peroxide results in increased activity of MPO protein] which results in increased oxidation of and results in increased susceptibility to 5-hydroxydiclofenac
CTD
PMID:28754375
NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935
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ADAM17
ADAM metallopeptidase domain 17
increases response to substance
ISO
ADAM17 results in increased susceptibility to aceclofenac
CTD
PMID:12147693
NCBI chr 2:9,488,486...9,555,830
Ensembl chr 2:9,488,486...9,556,732
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GDF15
growth differentiation factor 15
increases expression
EXP ISO
aceclofenac results in increased expression of GDF15 protein aceclofenac results in increased expression of GDF15 mRNA
CTD
PMID:15555568 PMID:18076062
NCBI chr19:18,386,158...18,389,176
Ensembl chr19:18,374,731...18,389,176
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SELL
selectin L
decreases expression
EXP
aceclofenac results in decreased expression of SELL protein
CTD
PMID:12147693
NCBI chr 1:169,690,667...169,711,620
Ensembl chr 1:169,690,665...169,711,702
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TNF
tumor necrosis factor
multiple interactions
ISO
[aceclofenac co-treated with Lipopolysaccharides] results in increased secretion of TNF protein
CTD
PMID:17328244
NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
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