Gene: IL4 (interleukin 4)  Homo sapiens Symbol: IL4 Name: interleukin 4 Description: The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] Type: protein-coding RefSeq Status: REVIEWED Also known as: B cell growth factor 1; B-cell stimulatory factor 1; B_cell stimulatory factor 1; BCGF-1; BCGF1; binetrakin; BSF-1; BSF-1; BSF1; IL-4; interleukin-4; lymphocyte stimulatory factor 1; MGC79402; OTTHUMP00000066049; OTTHUMP00000066050; pitrakinra Orthologs: Mus musculus : Il4 (interleukin 4)  MGI Rattus norvegicus : Il4 (interleukin 4) Latest Assembly: Human Genome Assembly GRCh37 Position: Map Chr Position Strand Source Human Alternate Assembly CHM1_1 5 132,286,522 - 132,295,219 + NCBI Human Genome Assembly HuRef 5 127,201,979 - 127,210,672 + NCBI Human Genome Assembly GRCh37 5 132,009,678 - 132,018,370 + NCBI Human Genome Assembly Build 36 5 132,037,272 - 132,046,267 + NCBI Human Cytogenetic Map 5 q31.1   NCBI Human Genome Assembly 5 132,037,271 - 132,046,267   NCBI Model Launch Genome Browser (GBrowse) : build 36 (hg18) build 37 (hg19) Annotation    (Toggle Detail/Summary View) Disease Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) Anti-Glomerular Basement Membrane Disease   ISS RGD:2898 2317673   RGD   Anti-Glomerular Basement Membrane Disease   ISS RGD:2898 2307059   RGD   Arthritis, Experimental   ISS RGD:2898 2317300   RGD   Asthma   ISS RGD:2898 5128500 mRNA:increased expression:lung, spleen RGD   Asthma   ISS RGD:10796 5128502 protein:increased expression:respiratory system fluid/secretion RGD   Asthma No_Association IAGP   5128560 DNA:SNP: :589C>T (human) RGD   Asthma   IAGP   4889866 DNA:polymorphism (human) RGD   Asthma   ISS RGD:2898 2317290 protein:increased expression:lung RGD   Asthma   ISS RGD:10796 5128557   RGD   Behcet Syndrome   IAGP   5147902 DNA:polymorphisms:promoter:-33T>C (human) RGD   Biliary Tract Neoplasms   IPM   2317263   RGD   Bronchiolitis Obliterans   ISS RGD:2898 2317286 protein:increased expression:serum RGD   Carcinoma, Pancreatic Ductal   IPM   2317264   RGD   Cholestasis   ISS RGD:2898 2317270   RGD   Common Cold   ISS RGD:10796 4140459 associated with Asthma;mRNA, protein:increased expression:alveolar macrophage, respiratory system fluid/secretion RGD   Cystitis   ISS RGD:2898 2317284 protein:increased expression:urine RGD   Dermatitis, Irritant   ISS RGD:2898 2317271   RGD   Gaucher Disease   ISS RGD:10796 5128511 protein:increased expression:lung RGD   Hypertension, Pulmonary   ISS RGD:10796 5128515   RGD   Influenza, Human   ISS RGD:10796 5128546   RGD   Multiple Sclerosis   IAGP   1358745   RGD   Nematode Infections   ISS RGD:2898 2317296 mRNA:increased expression:spleen RGD   Nephritis   ISS RGD:2898 5128564   RGD   Osteoarthritis, Knee   ISS RGD:2898 2317291   RGD   Otitis Media with Effusion   ISS RGD:2898 2317282 protein:increased expression:middle ear RGD   Pancreatic Neoplasms   ISS RGD:10796 2317267   RGD   Pancreatic Neoplasms Disease_progression IEP   2317261 protein:increased expression:blood RGD   Pancreatic Neoplasms   IPM   2317265   RGD   Pulmonary Fibrosis   ISS RGD:10796 5128548 associated with Alveolitis, Extrinsic Allergic;mRNA:increased expression:lung RGD   Pulmonary Fibrosis   ISS RGD:10796 5128555 associated with Silicosis;protein:increased expression:respiratory system fluid/secretion RGD   Respiratory Hypersensitivity   ISS RGD:10796 5128506 associated with Pneumonia, Pneumocystis carinii RGD   Respiratory Tract Infections   IEP   5128554 associated with Asthma RGD   Rhinitis   ISS RGD:10796 5128558 mRNA:increased expression:nasal cavity epithelium RGD   Rhinitis   ISS RGD:2898 2317285 protein:increased expression:serum RGD   Rhinitis, Allergic, Perennial   IEP   5128559   RGD   Spinal Cord Injuries   ISS RGD:2898 5128562   RGD   Tuberculosis, Pulmonary Severity ISS RGD:10796 5128550   RGD   Gene-Chemical Interaction Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) (+)-trans-(S)-allethrin multiple interactions EXP   6480464 [bioallethrin co-treated with Piperonyl Butoxide] results in increased expression of IL4 protein CTD PMID:10414782 (+)-trans-(S)-allethrin affects expression EXP   6480464 bioallethrin affects the expression of IL4 protein CTD PMID:9860237 1,3,5-trinitrobenzene increases expression ISO RGD:10796 6480464 sym-trinitrobenzene results in increased expression of IL4 mRNA CTD PMID:15890784 1,4-phenylenediamine increases expression ISO RGD:10796 6480464 4-phenylenediamine results in increased expression of IL4 mRNA CTD PMID:11531941 1,4-phenylenediamine increases secretion ISO RGD:10796 6480464 4-phenylenediamine results in increased secretion of IL4 protein CTD PMID:22245253 1-chloro-2,4,6-trinitrobenzene multiple interactions EXP   6480464 4-cyano-4-(2,3-dihydro-8-methoxy-1,4-benzodioxin-5-yl)cyclohexanecarboxylic acid inhibits the reaction [Picryl Chloride results in increased expression of IL4 protein] CTD PMID:18854230 1-chloro-2,4,6-trinitrobenzene increases expression ISO RGD:10796 6480464 Picryl Chloride results in increased expression of IL4 mRNA CTD PMID:21804303 1-chloro-2,4,6-trinitrobenzene multiple interactions ISO RGD:10796 6480464 Dexamethasone inhibits the reaction [Picryl Chloride results in increased expression of IL4 mRNA] CTD PMID:21804303 1-chloro-2,4,6-trinitrobenzene increases expression ISO RGD:10796 6480464 Picryl Chloride results in increased expression of IL4 protein CTD PMID:12188032 more ... 1-chloro-2,4,6-trinitrobenzene increases expression ISO RGD:10796 6480464 Picryl Chloride results in increased expression of IL4 protein CTD PMID:16442096 more ... 1-chloro-2,4,6-trinitrobenzene increases expression ISO RGD:10796 6480464 Picryl Chloride results in increased expression of IL4 protein CTD PMID:15734285 more ... 1-chloro-2,4,6-trinitrobenzene multiple interactions ISO RGD:10796 6480464 Cyclosporine inhibits the reaction [Picryl Chloride results in increased expression of IL4 protein]; more ... CTD PMID:16442096 1-chloro-2,4,6-trinitrobenzene multiple interactions ISO RGD:10796 6480464 bu-zhong-yi-qi-tang inhibits the reaction [Picryl Chloride results in increased expression of IL4 protein] CTD PMID:12188032 1-chloro-2,4,6-trinitrobenzene increases expression ISO RGD:10796 6480464 Picryl Chloride results in increased expression of IL4 protein CTD PMID:12188032 more ... 1-chloro-2,4,6-trinitrobenzene multiple interactions ISO RGD:10796 6480464 [Picryl Chloride co-treated with pirinixic acid] results in decreased expression of IL4 protein; more ... CTD PMID:17371993 1-chloro-2,4,6-trinitrobenzene increases expression EXP   6480464 Picryl Chloride results in increased expression of IL4 protein CTD PMID:18854230 1-chloro-2,4-dinitrobenzene increases expression ISO RGD:10796 6480464 Dinitrochlorobenzene results in increased expression of IL4 mRNA CTD PMID:15664275 PMID:18652873 1-chloro-2,4-dinitrobenzene multiple interactions ISO RGD:10796 6480464 Biological Agents inhibits the reaction [Dinitrochlorobenzene results in increased expression of IL4 mRNA] CTD PMID:23200891 1-chloro-2,4-dinitrobenzene increases expression ISO RGD:10796 6480464 Dinitrochlorobenzene results in increased expression of IL4 mRNA CTD PMID:15664275 more ... 1-chloro-2,4-dinitrobenzene increases expression ISO RGD:10796 6480464 Dinitrochlorobenzene results in increased expression of IL4 protein CTD PMID:15588918 PMID:19422874 1-chloro-2,4-dinitrobenzene increases expression ISO RGD:10796 6480464 Dinitrochlorobenzene results in increased expression of IL4 mRNA CTD PMID:18652873 PMID:15664275 1-chloro-2,4-dinitrobenzene affects expression ISO RGD:10796 6480464 Dinitrochlorobenzene affects the expression of IL4 mRNA CTD PMID:22302311 1-chloro-2,4-dinitrobenzene increases expression ISO RGD:10796 6480464 Dinitrochlorobenzene results in increased expression of IL4 protein CTD PMID:15588918 17alpha-ethynylestradiol decreases secretion ISO RGD:10796 6480464 Ethinyl Estradiol results in decreased secretion of IL4 protein CTD PMID:12538720 17alpha-ethynylestradiol multiple interactions ISO RGD:10796 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of IL4 mRNA CTD PMID:17942748 17alpha-ethynylestradiol decreases expression ISO RGD:10796 6480464 Ethinyl Estradiol results in decreased expression of IL4 mRNA CTD PMID:17942748 17alpha-ethynylestradiol affects expression ISO RGD:10796 6480464 Ethinyl Estradiol affects the expression of IL4 mRNA CTD PMID:17555576 17beta-estradiol decreases secretion ISO RGD:10796 6480464 Estradiol results in decreased secretion of IL4 protein CTD PMID:12538720 17beta-estradiol increases secretion ISO RGD:10796 6480464 Estradiol results in increased secretion of IL4 protein CTD PMID:12711627 2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9-hexadecafluorononanoic acid decreases expression ISO RGD:10796 6480464 hexadecafluoro-nonanoic acid results in decreased expression of IL4 protein CTD PMID:18583369 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:10796 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of IL4 mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:10796 6480464 Tetrachlorodibenzodioxin results in decreased expression of IL4 mRNA CTD PMID:12167310 PMID:9224809 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:10796 6480464 Tetrachlorodibenzodioxin results in decreased expression of IL4 mRNA CTD PMID:12167310 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP   6480464 Tetrachlorodibenzodioxin promotes the reaction [IL4 protein results in increased expression of CYP1A1 protein] CTD PMID:15899923 2,4,6-trinitrobenzenesulfonic acid increases expression ISO RGD:10796 6480464 Trinitrobenzenesulfonic Acid results in increased expression of IL4 mRNA CTD PMID:15973123 2,4,6-trinitrobenzenesulfonic acid decreases expression ISO RGD:2898 6480464 Trinitrobenzenesulfonic Acid results in decreased expression of IL4 mRNA CTD PMID:16867261 PMID:16782535 2,4,6-trinitrobenzenesulfonic acid multiple interactions ISO RGD:2898 6480464 Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL4 mRNA] CTD PMID:16782535 PMID:16867261 2,4,6-trinitrobenzenesulfonic acid decreases expression ISO RGD:2898 6480464 Trinitrobenzenesulfonic Acid results in decreased expression of IL4 protein CTD PMID:16867261 2,4,6-trinitrobenzenesulfonic acid decreases expression ISO RGD:2898 6480464 Trinitrobenzenesulfonic Acid results in decreased expression of IL4 mRNA CTD PMID:16782535 PMID:16867261 2,4,6-trinitrobenzenesulfonic acid multiple interactions ISO RGD:2898 6480464 Dexamethasone inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL4 mRNA]; more ... CTD PMID:16867261 2,4,6-trinitrobenzenesulfonic acid multiple interactions ISO RGD:2898 6480464 Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL4 mRNA] CTD PMID:16867261 PMID:16782535 2,4-D increases expression ISO RGD:10796 6480464 2,4-Dichlorophenoxyacetic Acid results in increased expression of IL4 protein CTD PMID:19467290 2,4-D increases secretion ISO RGD:10796 6480464 2,4-Dichlorophenoxyacetic Acid results in increased secretion of IL4 protein CTD PMID:19467290 2,6-di-tert-butyl-4-methylphenol multiple interactions ISO RGD:10796 6480464 Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of IL4 protein] CTD PMID:16822543 2-amino-2-deoxy-D-glucopyranose decreases secretion ISO RGD:10796 6480464 Glucosamine results in decreased secretion of IL4 protein CTD PMID:14507305 2-amino-2-deoxy-D-glucopyranose decreases expression EXP   6480464 Glucosamine results in decreased expression of IL4 CTD PMID:21284687 3,3',5,5'-tetrabromobisphenol A increases expression ISO RGD:10796 6480464 tetrabromobisphenol A results in increased expression of IL4 protein CTD PMID:22972382 3H-1,2-dithiole-3-thione increases expression ISO RGD:2898 6480464 1,2-dithiol-3-thione results in increased expression of IL4 mRNA CTD PMID:19162173 4,4'-diaminodiphenylmethane increases expression EXP   6480464 4,4'-diaminodiphenylmethane results in increased expression of IL4 protein CTD PMID:9034685 4-(ethoxymethylene)-2-phenyloxazol-5-one increases expression ISO RGD:10796 6480464 Oxazolone results in increased expression of IL4 mRNA CTD PMID:18652873 PMID:11708898 4-(ethoxymethylene)-2-phenyloxazol-5-one increases expression ISO RGD:10796 6480464 Oxazolone results in increased expression of IL4 protein CTD PMID:19422874 4-(ethoxymethylene)-2-phenyloxazol-5-one increases expression ISO RGD:10796 6480464 Oxazolone results in increased expression of IL4 mRNA CTD PMID:11708898 PMID:18652873 4-ethylphenol increases expression ISO RGD:10796 6480464 4-ethylphenol results in increased expression of IL4 mRNA; more ... CTD PMID:16169028 4-nonylphenol affects secretion EXP   6480464 4-nonylphenol affects the secretion of IL4 protein CTD PMID:20194071 4-tolyl isocyanate increases expression ISO RGD:10796 6480464 4-tolyl isocyanate results in increased expression of IL4 mRNA CTD PMID:15664275 4-tolyl isocyanate increases expression ISO RGD:10796 6480464 4-tolyl isocyanate results in increased expression of IL4 protein CTD PMID:22381623 5-azacytidine affects methylation EXP   6480464 Azacitidine affects the methylation of IL4 promoter CTD PMID:18158872 6alpha-methylprednisolone multiple interactions EXP   6480464 Methylprednisolone inhibits the reaction [IL4 protein promotes the reaction [STAT6 protein binds to FCER2 promoter]]; more ... CTD PMID:11997017 8-bromo-3',5'-cyclic AMP increases expression EXP   6480464 8-Bromo Cyclic Adenosine Monophosphate results in increased expression of IL4 mRNA CTD PMID:22079614 8-bromo-3',5'-cyclic GMP multiple interactions ISO RGD:10796 6480464 Cyclosporine inhibits the reaction [8-bromocyclic GMP results in increased expression of IL4 mRNA] CTD PMID:16533816 8-bromo-3',5'-cyclic GMP increases expression ISO RGD:10796 6480464 8-bromocyclic GMP results in increased expression of IL4 mRNA CTD PMID:16533816 9-cis-retinoic acid increases expression EXP   6480464 alitretinoin results in increased expression of IL4 mRNA; more ... CTD PMID:17118196 acetaldehyde multiple interactions EXP   6480464 IL4 protein inhibits the reaction [Acetaldehyde results in increased degradation of NFKBIA protein]; more ... CTD PMID:15698409 acetone multiple interactions EXP   6480464 [Acetone co-treated with olive oil] results in increased expression of IL4 mRNA CTD PMID:21252390 acetylsalicylic acid multiple interactions EXP   6480464 Aspirin inhibits the reaction [IL4 results in increased activity of STAT6 protein]; more ... CTD PMID:19767084 acetylsalicylic acid decreases secretion EXP   6480464 Aspirin results in decreased secretion of IL4 protein CTD PMID:11238116 acetylsalicylic acid decreases expression EXP   6480464 Aspirin results in decreased expression of IL4 mRNA CTD PMID:11238116 acetylsalicylic acid multiple interactions EXP   6480464 Aspirin promotes the reaction [CEBPB protein binds to IL4 promoter polymorphism] CTD PMID:20921925 acetylsalicylic acid increases expression EXP   6480464 Aspirin results in increased expression of IL4 mRNA CTD PMID:20921925 acrylic acid decreases expression ISO RGD:2898 6480464 acrylic acid results in decreased expression of IL4 protein CTD PMID:19145326 alclometasone dipropionate decreases expression EXP   6480464 alclometasone dipropionate results in decreased expression of IL4 protein CTD PMID:11407316 aldehydo-D-glucosamine decreases secretion ISO RGD:10796 6480464 Glucosamine results in decreased secretion of IL4 protein CTD PMID:14507305 aldehydo-D-glucosamine decreases expression EXP   6480464 Glucosamine results in decreased expression of IL4 CTD PMID:21284687 all-trans-retinoic acid multiple interactions EXP   6480464 Ro 41-5253 inhibits the reaction [Tretinoin results in increased secretion of IL4 protein]; more ... CTD PMID:16872382 all-trans-retinoic acid increases expression EXP   6480464 Tretinoin results in increased expression of IL4 mRNA CTD PMID:15189689 more ... all-trans-retinoic acid increases expression EXP   6480464 Tretinoin results in increased expression of IL4 mRNA CTD PMID:15189689 more ... all-trans-retinoic acid increases expression EXP   6480464 Tretinoin results in increased expression of IL4 mRNA CTD PMID:16872382 more ... all-trans-retinoic acid increases expression EXP   6480464 Tretinoin results in increased expression of IL4 mRNA CTD PMID:17118196 more ... all-trans-retinoic acid increases expression EXP   6480464 Tretinoin results in increased expression of IL4 mRNA CTD PMID:17118196 more ... all-trans-retinoic acid multiple interactions ISO RGD:2898 6480464 IL4 protein inhibits the reaction [Tretinoin results in increased activity of ALPL protein] CTD PMID:11171635 all-trans-retinoic acid increases secretion EXP   6480464 Tretinoin results in increased secretion of IL4 protein CTD PMID:16872382 all-trans-retinoic acid increases expression EXP   6480464 Tretinoin results in increased expression of IL4 protein CTD PMID:17118196 all-trans-retinoic acid increases expression EXP   6480464 Tretinoin results in increased expression of IL4 mRNA CTD PMID:16872382 more ... all-trans-retinoic acid multiple interactions EXP   6480464 Tretinoin affects the reaction [IL4 protein results in increased expression of ALOX15 protein] CTD PMID:15996861 all-trans-retinoic acid decreases activity EXP   6480464 IL4 protein results in decreased activity of Tretinoin CTD PMID:11171635 all-trans-retinol decreases expression ISO RGD:10796 6480464 Vitamin A results in decreased expression of IL4 protein CTD PMID:14624943 alpha-hexylcinnamaldehyde affects expression ISO RGD:10796 6480464 hexyl cinnamic aldehyde affects the expression of IL4 mRNA CTD PMID:22302311 alpha-linolenic acid multiple interactions EXP   6480464 [Eicosapentaenoic Acid co-treated with Docosahexaenoic Acids co-treated with alpha-Linolenic Acid] results in decreased expression of IL4 protein CTD PMID:16305726 aluminium atom increases expression ISO RGD:10796 6480464 Aluminum results in increased expression of IL4 mRNA CTD PMID:16630673 aluminium hydroxide increases expression ISO RGD:10796 6480464 Aluminum Hydroxide results in increased expression of IL4 mRNA CTD PMID:9328138 aluminium hydroxide multiple interactions EXP   6480464 Aluminum Hydroxide inhibits the reaction [[CSF2 protein co-treated with IL4 protein] results in increased expression of CD80 protein]; more ... CTD PMID:18390722 aluminium hydroxide affects response to substance EXP   6480464 IL4 protein affects the susceptibility to Aluminum Hydroxide CTD PMID:11160013 aluminium hydroxide increases expression EXP   6480464 Aluminum Hydroxide results in increased expression of IL4 mRNA CTD PMID:11160013 aluminium(0) increases expression ISO RGD:10796 6480464 Aluminum results in increased expression of IL4 mRNA CTD PMID:16630673 ammonium chloride affects expression ISO RGD:2898 6480464 Ammonium Chloride affects the expression of IL4 mRNA CTD PMID:16483693 apigenin decreases expression EXP   6480464 Apigenin results in decreased expression of IL4 protein CTD PMID:16343431 arachidonic acid multiple interactions EXP   6480464 [IL4 protein co-treated with Arachidonic Acid] results in increased activity of ALOX15 protein; more ... CTD PMID:11861792 asbestos increases expression ISO RGD:10796 6480464 Asbestos results in increased expression of IL4 protein CTD PMID:18795166 azathioprine decreases expression EXP   6480464 Azathioprine results in decreased expression of IL4 protein CTD PMID:19584951 BAPTA multiple interactions EXP   6480464 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL4 protein] CTD PMID:20371970 benzene affects response to substance EXP   6480464 IL4 promoter SNP affects the susceptibility to Benzene CTD PMID:16230423 benzo[a]pyrene multiple interactions ISO RGD:10796 6480464 Benzo(a)pyrene promotes the reaction [AHR protein binds to IL4 promoter] CTD PMID:19654925 benzo[a]pyrene affects expression EXP   6480464 Benzo(a)pyrene affects the expression of IL4 mRNA CTD PMID:22562770 berberine multiple interactions ISO RGD:10796 6480464 Berberine inhibits the reaction [Lipopolysaccharides results in decreased expression of IL4 mRNA] CTD PMID:21867779 berberine increases expression ISO RGD:10796 6480464 Berberine results in increased expression of IL4 mRNA CTD PMID:21867779 beta-D-glucosamine decreases secretion ISO RGD:10796 6480464 Glucosamine results in decreased secretion of IL4 protein CTD PMID:14507305 beta-D-glucosamine decreases expression EXP   6480464 Glucosamine results in decreased expression of IL4 CTD PMID:21284687 betamethasone valerate decreases expression EXP   6480464 Betamethasone 17-Valerate results in decreased expression of IL4 protein CTD PMID:11407316 bifenthrin increases expression ISO RGD:10796 6480464 bifenthrin results in increased expression of IL4 mRNA CTD PMID:23172818 biochanin A increases expression ISO RGD:10796 6480464 biochanin A results in increased expression of IL4 mRNA; more ... CTD PMID:16169028 bis(2-chloroethyl) sulfide decreases expression ISO RGD:10796 6480464 Mustard Gas results in decreased expression of IL4 mRNA CTD PMID:15674843 bis(2-chloroethyl) sulfide decreases expression ISO RGD:2898 6480464 Mustard Gas results in decreased expression of IL4 protein CTD PMID:19145326 bis(2-ethylhexyl) phthalate multiple interactions EXP   6480464 Plant Extracts inhibits the reaction [Diethylhexyl Phthalate results in increased expression of IL4 mRNA] CTD PMID:20082445 bis(2-ethylhexyl) phthalate multiple interactions ISO RGD:10796 6480464 [Diethylhexyl Phthalate co-treated with CSF2] results in increased expression of IL4 protein CTD PMID:19428943 bis(2-ethylhexyl) phthalate increases expression EXP   6480464 Diethylhexyl Phthalate results in increased expression of IL4 mRNA CTD PMID:20082445 bisphenol A multiple interactions ISO RGD:10796 6480464 bisphenol A promotes the reaction [[[Tetradecanoylphorbol Acetate co-treated with Ionomycin] promotes the reaction [NFATC3 protein binds to IL4 promoter]] which results in increased expression of IL4 mRNA] CTD PMID:12709020 PMID:12709020 bisphenol A increases secretion ISO RGD:10796 6480464 bisphenol A results in increased secretion of IL4 protein CTD PMID:12711627 bisphenol A decreases expression ISO RGD:10796 6480464 bisphenol A results in decreased expression of IL4 protein CTD PMID:12510852 bisphenol A increases expression ISO RGD:10796 6480464 bisphenol A results in increased expression of IL4 mRNA; more ... CTD PMID:12709020 bisphenol A multiple interactions EXP   6480464 Drugs, Chinese Herbal inhibits the reaction [bisphenol A results in increased expression of IL4 mRNA] CTD PMID:19415476 bisphenol A multiple interactions ISO RGD:10796 6480464 bisphenol A promotes the reaction [NFATC3 protein binds to IL4 promoter]; more ... CTD PMID:12709020 bisphenol A increases expression EXP   6480464 bisphenol A results in increased expression of IL4 mRNA CTD PMID:19415476 bleomycin A2 increases expression ISO RGD:10796 6480464 Bleomycin results in increased expression of IL4 mRNA CTD PMID:11554783 bleomycin A2 affects response to substance ISO RGD:10796 6480464 IL4 protein affects the susceptibility to Bleomycin CTD PMID:12574379 bleomycin A2 multiple interactions ISO RGD:10796 6480464 IL4 protein affects the reaction [Bleomycin results in increased expression of RETNLA mRNA] CTD PMID:15322207 bleomycin A2 decreases response to substance ISO RGD:10796 6480464 IL4 gene mutant form results in decreased susceptibility to Bleomycin CTD PMID:15322207 budesonide decreases expression ISO RGD:10796 6480464 Budesonide results in decreased expression of IL4 protein CTD PMID:12406821 PMID:15086961 budesonide decreases expression ISO RGD:10796 6480464 Budesonide results in decreased expression of IL4 protein CTD PMID:15086961 PMID:12406821 cadmium atom decreases expression ISO RGD:2898 6480464 Cadmium results in decreased expression of IL4 protein CTD PMID:20455018 cadmium atom multiple interactions ISO RGD:2898 6480464 Lithium inhibits the reaction [Cadmium results in decreased expression of IL4 protein] CTD PMID:20455018 calcitriol increases expression ISO RGD:2898 6480464 Calcitriol results in increased expression of IL4 protein CTD PMID:11679963 calcium atom multiple interactions ISO RGD:10796 6480464 IL4 protein inhibits the reaction [IL11 protein results in increased abundance of Calcium] CTD PMID:12110441 calcium(0) multiple interactions ISO RGD:10796 6480464 IL4 protein inhibits the reaction [IL11 protein results in increased abundance of Calcium] CTD PMID:12110441 capsaicin decreases expression ISO RGD:10796 6480464 Capsaicin results in decreased expression of IL4 CTD PMID:17306834 capsaicin increases expression ISO RGD:2898 6480464 Capsaicin results in increased expression of IL4 protein CTD PMID:22150557 capsaicin multiple interactions ISO RGD:2898 6480464 [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of IL4 protein]; more ... CTD PMID:22150557 carbachol increases expression ISO RGD:10796 6480464 Carbachol results in increased expression of IL4 mRNA CTD PMID:15698499 carbon monoxide decreases expression ISO RGD:10796 6480464 Carbon Monoxide results in decreased expression of IL4 protein CTD PMID:21444764 cetirizine decreases expression ISO RGD:10796 6480464 Cetirizine results in decreased expression of IL4 protein CTD PMID:19672097 chlorambucil multiple interactions EXP   6480464 IL4 protein inhibits the reaction [Chlorambucil results in decreased expression of BCL2 protein]; more ... CTD PMID:8822937 chloroform decreases expression ISO RGD:10796 6480464 Chloroform results in decreased expression of IL4 protein CTD PMID:16879906 chlorphenamine multiple interactions ISO RGD:2898 6480464 Chlorpheniramine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA] CTD PMID:19075512 chromium atom multiple interactions ISO RGD:2898 6480464 [Vanadium co-treated with Selenium co-treated with Vitamin E co-treated with Chromium] results in increased expression of IL4 protein CTD PMID:15862027 chromium(6+) increases expression EXP   6480464 chromium hexavalent ion results in increased expression of IL4 protein CTD PMID:19051261 cilostazol multiple interactions ISO RGD:10796 6480464 cilostazol inhibits the reaction [4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone results in decreased expression of IL4 protein] CTD PMID:15169552 ciprofloxacin decreases expression EXP   6480464 Ciprofloxacin results in decreased expression of IL4 protein CTD PMID:16006447 cis-ketoconazole decreases secretion EXP   6480464 Ketoconazole results in decreased secretion of IL4 protein CTD PMID:15284827 cis-ketoconazole decreases expression EXP   6480464 Ketoconazole results in decreased expression of IL4 mRNA CTD PMID:15284827 cisplatin multiple interactions EXP   6480464 Cisplatin inhibits the reaction [[TNF co-treated with IL4] results in increased expression of PDCD1LG2] CTD PMID:21765211 cladribine increases expression EXP   6480464 Cladribine results in increased expression of IL4 mRNA CTD PMID:9751108 clarithromycin decreases expression EXP   6480464 Clarithromycin results in decreased expression of IL4 protein CTD PMID:16006447 cobalt atom decreases secretion EXP   6480464 Cobalt results in decreased secretion of IL4 protein CTD PMID:17291400 cobalt dichloride increases expression ISO RGD:10796 6480464 cobaltous chloride results in increased expression of IL4 protein CTD PMID:20511350 cobalt dichloride multiple interactions ISO RGD:10796 6480464 HIF1A inhibits the reaction [cobaltous chloride results in increased expression of IL4 protein] CTD PMID:20511350 cocaine multiple interactions EXP   6480464 [Cocaine co-treated with Heroin] results in increased expression of IL4 protein CTD PMID:16766138 curcumin multiple interactions ISO RGD:2898 6480464 Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL4 protein] CTD PMID:16867261 curcumin decreases expression ISO RGD:10796 6480464 Curcumin results in decreased expression of IL4 protein CTD PMID:21397623 curcumin multiple interactions ISO RGD:2898 6480464 Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL4 mRNA] CTD PMID:16782535 PMID:16867261 curcumin multiple interactions ISO RGD:2898 6480464 Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL4 mRNA] CTD PMID:16867261 PMID:16782535 cyclophosphamide increases expression ISO RGD:2898 6480464 Cyclophosphamide results in increased expression of IL4 protein CTD PMID:18848347 cyclophosphamide increases expression ISO RGD:10796 6480464 Cyclophosphamide results in increased expression of IL4 mRNA CTD PMID:11006010 PMID:22842586 cyclophosphamide increases expression ISO RGD:2898 6480464 Cyclophosphamide results in increased expression of IL4 mRNA CTD PMID:11948286 cyclophosphamide increases expression ISO RGD:10796 6480464 Cyclophosphamide results in increased expression of IL4 mRNA; more ... CTD PMID:11006010 cyclophosphamide decreases expression ISO RGD:10796 6480464 Cyclophosphamide results in decreased expression of IL4 mRNA CTD PMID:11014644 cyclosporin A multiple interactions EXP   6480464 Cyclosporine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL4 protein] CTD PMID:1371491 cyclosporin A multiple interactions ISO RGD:2898 6480464 Cyclosporine inhibits the reaction [dinitrophenyl-human serum albumin conjugate results in increased expression of IL4 protein] CTD PMID:11233995 cyclosporin A multiple interactions ISO RGD:10796 6480464 Cyclosporine inhibits the reaction [Picryl Chloride results in increased expression of IL4 protein] CTD PMID:16442096 cyclosporin A decreases expression ISO RGD:10796 6480464 Cyclosporine results in decreased expression of IL4 protein CTD PMID:15588918 cyclosporin A multiple interactions ISO RGD:10796 6480464 [Cyclosporine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL4 protein CTD PMID:15588918 cyclosporin A multiple interactions ISO RGD:10796 6480464 Cyclosporine inhibits the reaction [8-bromocyclic GMP results in increased expression of IL4 mRNA]; more ... CTD PMID:16533816 D-penicillamine increases expression ISO RGD:2898 6480464 Penicillamine results in increased expression of IL4 mRNA CTD PMID:9182889 PMID:21227906 D-penicillamine increases expression ISO RGD:2898 6480464 Penicillamine results in increased expression of IL4 mRNA CTD PMID:21227906 PMID:9182889 daidzein increases expression ISO RGD:10796 6480464 daidzein results in increased expression of IL4 mRNA; more ... CTD PMID:16108819 dasatinib (anhydrous) decreases secretion ISO RGD:10796 6480464 dasatinib results in decreased secretion of IL4 protein CTD PMID:18180381 DDE multiple interactions EXP   6480464 [DDT co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of IL4 protein CTD PMID:12696651 DDT multiple interactions EXP   6480464 [DDT co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of IL4 protein CTD PMID:12696651 Delta(9)-tetrahydrocannabinol increases expression ISO RGD:10796 6480464 Tetrahydrocannabinol results in increased expression of IL4 CTD PMID:18792785 PMID:14741435 Delta(9)-tetrahydrocannabinol increases expression EXP   6480464 Tetrahydrocannabinol results in increased expression of IL4 mRNA CTD PMID:12446015 more ... Delta(9)-tetrahydrocannabinol increases expression ISO RGD:10796 6480464 Tetrahydrocannabinol results in increased expression of IL4 CTD PMID:14741435 PMID:18792785 Delta(9)-tetrahydrocannabinol increases expression EXP   6480464 Tetrahydrocannabinol results in increased expression of IL4 mRNA CTD PMID:16434616 more ... Delta(9)-tetrahydrocannabinol increases expression EXP   6480464 Tetrahydrocannabinol results in increased expression of IL4 protein CTD PMID:12446015 Delta(9)-tetrahydrocannabinol multiple interactions EXP   6480464 SR 144528 inhibits the reaction [Tetrahydrocannabinol results in increased expression of IL4 protein]; more ... CTD PMID:12446015 Delta(9)-tetrahydrocannabinol multiple interactions EXP   6480464 IL4 protein mutant form inhibits the reaction [Tetrahydrocannabinol results in increased expression of CNR1 mRNA]; more ... CTD PMID:17041005 Delta(9)-tetrahydrocannabinol multiple interactions EXP   6480464 IL4 protein mutant form inhibits the reaction [Tetrahydrocannabinol results in increased expression of OPRM1 mRNA]; more ... CTD PMID:16434616 Delta(9)-tetrahydrocannabinol increases secretion EXP   6480464 Tetrahydrocannabinol results in increased secretion of IL4 protein CTD PMID:12446015 desferrioxamine B multiple interactions ISO RGD:2898 6480464 Deferoxamine inhibits the reaction [Mercuric Chloride results in increased expression of IL4 mRNA] CTD PMID:11222498 dexamethasone multiple interactions EXP   6480464 [Dexamethasone co-treated with IL4 protein] results in increased expression of CHID1 mRNA; more ... CTD PMID:16357325 dexamethasone increases expression ISO RGD:10796 6480464 Dexamethasone results in increased expression of IL4 mRNA; more ... CTD PMID:22842586 dexamethasone multiple interactions EXP   6480464 [IL4 protein co-treated with IL2 protein] results in decreased susceptibility to Dexamethasone CTD PMID:22205926 dexamethasone multiple interactions ISO RGD:10796 6480464 Dexamethasone inhibits the reaction [Picryl Chloride results in increased expression of IL4 mRNA] CTD PMID:21804303 dexamethasone decreases expression EXP   6480464 Dexamethasone results in decreased expression of IL4 mRNA CTD PMID:10596698 dexamethasone multiple interactions ISO RGD:2898 6480464 Dexamethasone inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL4 mRNA]; more ... CTD PMID:16867261 dexamethasone decreases expression EXP   6480464 Dexamethasone results in decreased expression of IL4 protein CTD PMID:18357729 dexamethasone multiple interactions EXP   6480464 Dexamethasone inhibits the reaction [IL4 protein results in increased secretion of CSF2 protein]; more ... CTD PMID:12077271 dexamethasone multiple interactions EXP   6480464 Dexamethasone inhibits the reaction [IL4 protein results in increased expression of CCL26 protein] CTD PMID:16045735 diarsenic trioxide affects expression EXP   6480464 arsenic trioxide affects the expression of IL4 protein CTD PMID:18357729 diarsenic trioxide decreases expression ISO RGD:10796 6480464 arsenic trioxide results in decreased expression of IL4 mRNA CTD PMID:15073043 PMID:12243866 diarsenic trioxide decreases expression ISO RGD:10796 6480464 arsenic trioxide results in decreased expression of IL4 mRNA CTD PMID:12243866 PMID:15073043 diazinon affects expression ISO RGD:10796 6480464 Diazinon affects the expression of IL4 protein CTD PMID:17499902 diazinon decreases expression ISO RGD:10796 6480464 Diazinon results in decreased expression of IL4 mRNA CTD PMID:17499902 dibenzothiazol-2-yl disulfide multiple interactions ISO RGD:10796 6480464 [dibenzothiazyl disulfide co-treated with Sodium Dodecyl Sulfate] results in increased expression of IL4 protein CTD PMID:12062936 diclofenac increases response to substance EXP   6480464 IL4 gene polymorphism results in increased susceptibility to Diclofenac CTD PMID:15122773 dicloxacillin increases response to substance ISO RGD:10796 6480464 IL4 results in increased susceptibility to Dicloxacillin CTD PMID:21094227 dicloxacillin increases expression ISO RGD:10796 6480464 Dicloxacillin results in increased expression of IL4 protein CTD PMID:21094227 dicyclohexylmethane-4,4'-diisocyanate increases expression ISO RGD:10796 6480464 methylene bis(4-cyclohexylisocyanate) results in increased expression of IL4 mRNA CTD PMID:16940033 diflorasone diacetate multiple interactions ISO RGD:10796 6480464 diflorasone diacetate inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein] CTD PMID:12956900 diisononyl phthalate increases expression ISO RGD:10796 6480464 diisononyl phthalate results in increased expression of IL4 protein CTD PMID:20064775 dioxygen multiple interactions ISO RGD:2898 6480464 deguelin inhibits the reaction [Oxygen deficiency results in decreased expression of IL4 mRNA] CTD PMID:22745725 dioxygen decreases expression ISO RGD:2898 6480464 Oxygen deficiency results in decreased expression of IL4 mRNA CTD PMID:22745725 diphenylmethane-4,4'-diisocyanate increases expression ISO RGD:10796 6480464 4,4'-diphenylmethane diisocyanate results in increased expression of IL4 mRNA CTD PMID:11708898 PMID:16940033 diphenylmethane-4,4'-diisocyanate increases expression ISO RGD:10796 6480464 4,4'-diphenylmethane diisocyanate results in increased expression of IL4 protein CTD PMID:22381623 diphenylmethane-4,4'-diisocyanate increases expression ISO RGD:10796 6480464 4,4'-diphenylmethane diisocyanate results in increased expression of IL4 mRNA CTD PMID:16940033 PMID:11708898 dydrogesterone increases expression EXP   6480464 Dydrogesterone results in increased expression of IL4 protein CTD PMID:16045524 dydrogesterone increases expression ISO RGD:10796 6480464 Dydrogesterone results in increased expression of IL4 protein CTD PMID:16389545 dydrogesterone multiple interactions EXP   6480464 Mifepristone inhibits the reaction [Dydrogesterone results in increased expression of IL4 protein] CTD PMID:16045524 edaravone multiple interactions ISO RGD:2898 6480464 phenylmethylpyrazolone inhibits the reaction [Carbon Tetrachloride results in increased expression of IL4 mRNA] CTD PMID:14567445 elemental selenium decreases expression ISO RGD:10796 6480464 Selenium results in decreased expression of IL4 protein CTD PMID:14624943 elemental selenium multiple interactions ISO RGD:10796 6480464 Selenium deficiency inhibits the reaction [IL4 protein results in increased expression of GPX1 protein]; more ... CTD PMID:21775527 elemental selenium multiple interactions ISO RGD:2898 6480464 [Vanadium co-treated with Selenium co-treated with Vitamin E co-treated with Chromium] results in increased expression of IL4 protein CTD PMID:15862027 emodin multiple interactions ISO RGD:10796 6480464 Emodin inhibits the reaction [Ovalbumin results in increased secretion of IL4 protein] CTD PMID:22484343 epinastine multiple interactions EXP   6480464 epinastine inhibits the reaction [IL4 results in decreased expression of IFNG] CTD PMID:16534218 epinastine multiple interactions ISO RGD:2898 6480464 epinastine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA] CTD PMID:19075512 estriol increases expression ISO RGD:10796 6480464 Estriol results in increased expression of IL4 protein CTD PMID:21317386 ethanol decreases expression ISO RGD:10796 6480464 Ethanol results in decreased expression of IL4 mRNA CTD PMID:7473187 ethanol multiple interactions ISO RGD:2898 6480464 Ethanol inhibits the reaction [fomepizole results in decreased expression of IL4 mRNA]; more ... CTD PMID:20116195 ethanol decreases expression ISO RGD:2898 6480464 Ethanol results in decreased expression of IL4 mRNA CTD PMID:20116195 ethanol increases activity ISO RGD:10796 6480464 Ethanol results in increased activity of IL4 protein CTD PMID:21086752 ethanol multiple interactions ISO RGD:10796 6480464 Mifepristone inhibits the reaction [Ethanol results in decreased expression of IL4 mRNA] CTD PMID:7473187 ethanol increases expression ISO RGD:10796 6480464 Ethanol results in increased expression of IL4 protein CTD PMID:16374292 etoposide decreases response to substance EXP   6480464 IL4 protein results in decreased susceptibility to Etoposide CTD PMID:10620629 etoposide multiple interactions EXP   6480464 [VCAM1 protein co-treated with IL4 protein] inhibits the reaction [Etoposide inhibits the reaction [BAX protein binds to BCL2L1 protein]]; more ... CTD PMID:10620629 famotidine multiple interactions ISO RGD:10796 6480464 Famotidine inhibits the reaction [Dimaprit inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL4 protein]] CTD PMID:19277450 ferric oxide multiple interactions ISO RGD:10796 6480464 [Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of IL4 protein CTD PMID:20540983 fisetin multiple interactions EXP   6480464 fisetin inhibits the reaction [[Calcimycin co-treated with phorbol-12-myristate] results in increased expression of IL4 protein]; more ... CTD PMID:12789233 fisetin decreases expression EXP   6480464 fisetin results in decreased expression of IL4 protein CTD PMID:16343431 fluoranthene increases expression EXP   6480464 fluoranthene results in increased expression of IL4 mRNA CTD PMID:18434080 fluoranthene multiple interactions EXP   6480464 TNF protein inhibits the reaction [fluoranthene results in increased expression of IL4 mRNA] CTD PMID:18434080 fomepizole multiple interactions ISO RGD:2898 6480464 Ethanol inhibits the reaction [fomepizole results in decreased expression of IL4 mRNA]; more ... CTD PMID:20116195 fomepizole decreases expression ISO RGD:2898 6480464 fomepizole results in decreased expression of IL4 mRNA CTD PMID:20116195 formaldehyde increases expression ISO RGD:10796 6480464 Formaldehyde results in increased expression of IL4 protein CTD PMID:19042193 formaldehyde affects expression ISO RGD:10796 6480464 Formaldehyde affects the expression of IL4 protein CTD PMID:19422874 formaldehyde increases expression ISO RGD:10796 6480464 Formaldehyde results in increased expression of IL4 mRNA CTD PMID:19904815 PMID:12161283 formaldehyde increases expression ISO RGD:2898 6480464 Formaldehyde results in increased expression of IL4 protein CTD PMID:19827972 formaldehyde increases expression ISO RGD:10796 6480464 Formaldehyde results in increased expression of IL4 mRNA CTD PMID:12161283 PMID:19904815 formononetin increases expression ISO RGD:10796 6480464 formononetin results in increased expression of IL4 mRNA; more ... CTD PMID:16108819 furfuryl alcohol increases expression ISO RGD:10796 6480464 furfuryl alcohol results in increased expression of IL4 protein CTD PMID:22003193 gadodiamide hydrate affects expression EXP   6480464 gadodiamide affects the expression of IL4 mRNA CTD PMID:19404939 gadodiamide hydrate increases expression EXP   6480464 gadodiamide results in increased expression of IL4 protein CTD PMID:19404939 gadolinium trichloride affects expression EXP   6480464 gadolinium chloride affects the expression of IL4 mRNA; more ... CTD PMID:19404939 genistein increases expression ISO RGD:10796 6480464 Genistein results in increased expression of IL4 mRNA; more ... CTD PMID:16169028 glutathione multiple interactions ISO RGD:10796 6480464 [IL4 gene mutant form results in increased susceptibility to Acetaminophen] which results in decreased abundance of Glutathione CTD PMID:22107450 glutathione multiple interactions EXP   6480464 [Patulin results in decreased abundance of Glutathione] which results in decreased secretion of IL4 protein CTD PMID:18214930 heptadecafluorononanoic acid increases secretion ISO RGD:2898 6480464 perfluoro-n-nonanoic acid results in increased secretion of IL4 protein CTD PMID:19196829 heroin multiple interactions EXP   6480464 [Cocaine co-treated with Heroin] results in increased expression of IL4 protein CTD PMID:16766138 hesperidin multiple interactions ISO RGD:10796 6480464 Hesperidin promotes the reaction [Lipopolysaccharides results in increased expression of IL4 protein] CTD PMID:17400256 hexachlorobenzene affects expression ISO RGD:2898 6480464 Hexachlorobenzene affects the expression of IL4 protein CTD PMID:11119253 hexamethylene diisocyanate increases expression ISO RGD:10796 6480464 1,6-hexamethylene diisocyanate results in increased expression of IL4 protein CTD PMID:12884401 hexamethylene diisocyanate increases secretion ISO RGD:10796 6480464 1,6-hexamethylene diisocyanate results in increased secretion of IL4 protein CTD PMID:17693426 hexamethylene diisocyanate increases expression ISO RGD:10796 6480464 1,6-hexamethylene diisocyanate results in increased expression of IL4 protein CTD PMID:12884401 PMID:19422874 hexamethylene diisocyanate increases expression ISO RGD:10796 6480464 1,6-hexamethylene diisocyanate results in increased expression of IL4 protein CTD PMID:19422874 PMID:12884401 histamine multiple interactions ISO RGD:10796 6480464 Histamine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL4 protein]; more ... CTD PMID:19277450 histamine increases response to substance ISO RGD:10796 6480464 IL4 protein results in increased susceptibility to Histamine CTD PMID:12370375 hydrogen peroxide increases activity ISO RGD:2898 6480464 Hydrogen Peroxide results in increased activity of IL4 promoter CTD PMID:11222498 hydrogen peroxide increases expression ISO RGD:2898 6480464 Hydrogen Peroxide results in increased expression of IL4 protein CTD PMID:11222498 hydroquinone multiple interactions ISO RGD:10796 6480464 hydroquinone promotes the reaction [keyhole-limpet hemocyanin results in increased expression of IL4 mRNA]; more ... CTD PMID:12153512 hydroxyzine decreases expression ISO RGD:10796 6480464 Hydroxyzine results in decreased expression of IL4 protein CTD PMID:19672097 ibuprofen multiple interactions ISO RGD:10796 6480464 [Ibuprofen co-treated with Lipopolysaccharides] results in increased expression of IL4 protein CTD PMID:19020770 indomethacin multiple interactions EXP   6480464 Indomethacin inhibits the reaction [interferon alfa-n1 results in increased secretion of IL4 protein] CTD PMID:15135802 indomethacin multiple interactions ISO RGD:2898 6480464 Sucralfate inhibits the reaction [Indomethacin results in decreased expression of IL4 protein] CTD PMID:10423059 indomethacin decreases expression ISO RGD:2898 6480464 Indomethacin results in decreased expression of IL4 protein CTD PMID:10423059 indomethacin decreases secretion EXP   6480464 Indomethacin results in decreased secretion of IL4 protein CTD PMID:15135802 ionomycin multiple interactions EXP   6480464 [Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL4 protein CTD PMID:17572062 ionomycin multiple interactions ISO RGD:10796 6480464 nonylphenol promotes the reaction [[[Tetradecanoylphorbol Acetate co-treated with Ionomycin] promotes the reaction [NFATC3 protein binds to IL4 promoter]] which results in increased expression of IL4 mRNA]; more ... CTD PMID:12709020 PMID:12709020 ionomycin multiple interactions ISO RGD:10796 6480464 Dimaprit inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL4 protein]; more ... CTD PMID:19277450 ionomycin multiple interactions ISO RGD:10796 6480464 deoxynivalenol promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL4 protein]; more ... CTD PMID:8658534 ionomycin multiple interactions ISO RGD:10796 6480464 [Cyclosporine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL4 protein; more ... CTD PMID:15588918 ionomycin multiple interactions ISO RGD:10796 6480464 bisphenol A promotes the reaction [[[Tetradecanoylphorbol Acetate co-treated with Ionomycin] promotes the reaction [NFATC3 protein binds to IL4 promoter]] which results in increased expression of IL4 mRNA]; more ... CTD PMID:12709020 isophorone diisocyanate increases expression ISO RGD:10796 6480464 isophorone diisocyanate results in increased expression of IL4 protein CTD PMID:19422874 isophorone diisocyanate increases secretion ISO RGD:10796 6480464 isophorone diisocyanate results in increased secretion of IL4 protein CTD PMID:17693426 isotretinoin decreases secretion ISO RGD:2898 6480464 Isotretinoin results in decreased secretion of IL4 protein CTD PMID:15972972 itraconazole decreases expression EXP   6480464 Itraconazole results in decreased expression of IL4 mRNA CTD PMID:15284827 itraconazole decreases secretion EXP   6480464 Itraconazole results in decreased secretion of IL4 protein CTD PMID:15284827 kaempferol multiple interactions EXP   6480464 kaempferol inhibits the reaction [Calcimycin results in increased expression of IL4 mRNA] CTD PMID:12789233 L-ascorbic acid decreases expression ISO RGD:10796 6480464 Ascorbic Acid results in decreased expression of IL4 protein CTD PMID:14624943 lead diacetate increases expression ISO RGD:10796 6480464 lead acetate results in increased expression of IL4 mRNA CTD PMID:20542052 leflunomide multiple interactions EXP   6480464 leflunomide inhibits the reaction [IL4 protein results in increased expression of CCL26 protein] CTD PMID:16045735 leflunomide multiple interactions ISO RGD:10796 6480464 leflunomide inhibits the reaction [[Selenium co-treated with IL4 protein] results in increased activity of ARG1 protein] CTD PMID:21775527 leukotriene B4 multiple interactions EXP   6480464 IL4 protein inhibits the reaction [Calcimycin results in increased metabolism of Leukotriene B4]; more ... CTD PMID:11861792 lidocaine decreases expression ISO RGD:10796 6480464 Lidocaine results in decreased expression of IL4 protein CTD PMID:18382663 lithium atom multiple interactions ISO RGD:2898 6480464 Lithium inhibits the reaction [Cadmium results in decreased expression of IL4 protein] CTD PMID:20455018 lithium atom increases expression ISO RGD:2898 6480464 Lithium results in increased expression of IL4 protein CTD PMID:20455018 luteolin multiple interactions EXP   6480464 Luteolin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL4] CTD PMID:16601352 luteolin multiple interactions ISO RGD:2898 6480464 Luteolin inhibits the reaction [Calcimycin results in increased expression of IL4 mRNA] CTD PMID:17950587 luteolin decreases expression ISO RGD:10796 6480464 Luteolin results in decreased expression of IL4 protein CTD PMID:12755373 luteolin decreases expression EXP   6480464 Luteolin results in decreased expression of IL4 protein CTD PMID:16343431 LY294002 multiple interactions ISO RGD:10796 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL4 protein results in increased phosphorylation of FOXO3A protein]; more ... CTD PMID:16179367 mercury atom decreases secretion ISO RGD:10796 6480464 Mercury results in decreased secretion of IL4 protein CTD PMID:15910788 mercury dichloride increases expression ISO RGD:2898 6480464 Mercuric Chloride results in increased expression of IL4 mRNA CTD PMID:9182889 mercury dichloride increases expression ISO RGD:10796 6480464 Mercuric Chloride results in increased expression of IL4 mRNA CTD PMID:12849721 more ... mercury dichloride affects response to substance ISO RGD:10796 6480464 IL4 protein affects the susceptibility to Mercuric Chloride CTD PMID:19077085 mercury dichloride increases expression EXP   6480464 Mercuric Chloride results in increased expression of IL4 protein CTD PMID:18075863 mercury dichloride multiple interactions ISO RGD:10796 6480464 B2M protein affects the reaction [Mercuric Chloride results in increased expression of IL4 mRNA] CTD PMID:21793797 mercury dichloride multiple interactions ISO RGD:10796 6480464 CD55 affects the reaction [Mercuric Chloride results in increased expression of IL4 mRNA] CTD PMID:20408894 mercury dichloride increases expression ISO RGD:2898 6480464 Mercuric Chloride results in increased expression of IL4 CTD PMID:10886234 mercury dichloride increases activity ISO RGD:2898 6480464 Mercuric Chloride results in increased activity of IL4 promoter CTD PMID:19604304 PMID:11222498 mercury dichloride increases expression ISO RGD:2898 6480464 Mercuric Chloride results in increased expression of IL4 mRNA CTD PMID:11222498 PMID:9182889 mercury dichloride increases expression ISO RGD:10796 6480464 Mercuric Chloride results in increased expression of IL4 mRNA CTD PMID:21793797 more ... mercury dichloride multiple interactions ISO RGD:10796 6480464 IL4 protein affects the reaction [Mercuric Chloride results in decreased activity of FBL protein] CTD PMID:19077085 mercury dichloride increases expression ISO RGD:2898 6480464 Mercuric Chloride results in increased expression of IL4 mRNA CTD PMID:9182889 PMID:11222498 mercury dichloride increases secretion ISO RGD:2898 6480464 Mercuric Chloride results in increased secretion of IL4 protein CTD PMID:19604304 mercury dichloride increases expression ISO RGD:10796 6480464 Mercuric Chloride results in increased expression of IL4 mRNA CTD PMID:12849721 mercury dichloride increases expression ISO RGD:2898 6480464 Mercuric Chloride results in increased expression of IL4 protein CTD PMID:11222498 mercury dichloride increases activity ISO RGD:2898 6480464 Mercuric Chloride results in increased activity of IL4 promoter CTD PMID:11222498 PMID:19604304 mercury dichloride multiple interactions ISO RGD:2898 6480464 Deferoxamine inhibits the reaction [Mercuric Chloride results in increased expression of IL4 mRNA]; more ... CTD PMID:11222498 mercury dichloride increases secretion ISO RGD:10796 6480464 Mercuric Chloride results in increased secretion of IL4 protein CTD PMID:12490134 mercury dichloride multiple interactions EXP   6480464 Mercuric Chloride inhibits the reaction [Lipopolysaccharides results in increased secretion of IL4 protein] CTD PMID:20049214 mercury(0) decreases secretion ISO RGD:10796 6480464 Mercury results in decreased secretion of IL4 protein CTD PMID:15910788 methanol decreases expression ISO RGD:2898 6480464 Methanol results in decreased expression of IL4 protein CTD PMID:19145326 methotrexate decreases expression EXP   6480464 Methotrexate results in decreased expression of IL4 protein CTD PMID:19100307 methotrexate decreases expression EXP   6480464 Methotrexate results in decreased expression of IL4 mRNA CTD PMID:17400583 methotrexate multiple interactions EXP   6480464 SB 203580 inhibits the reaction [Methotrexate results in decreased expression of IL4 protein] CTD PMID:19100307 methoxychlor multiple interactions ISO RGD:10796 6480464 [Methoxychlor co-treated with Antigens, Dermatophagoides] affects the expression of IL4 protein CTD PMID:21864637 methoxychlor increases expression ISO RGD:10796 6480464 Methoxychlor results in increased expression of IL4 mRNA; more ... CTD PMID:22842586 methyl isocyanate increases expression EXP   6480464 methyl isocyanate results in increased expression of IL4 protein CTD PMID:19295137 methyl salicylate affects expression ISO RGD:10796 6480464 methyl salicylate affects the expression of IL4 mRNA CTD PMID:22302311 miconazole decreases secretion EXP   6480464 Miconazole results in decreased secretion of IL4 protein CTD PMID:15284827 miconazole decreases expression EXP   6480464 Miconazole results in decreased expression of IL4 mRNA CTD PMID:15284827 mifepristone multiple interactions EXP   6480464 Mifepristone inhibits the reaction [Dydrogesterone results in increased expression of IL4 protein] CTD PMID:16045524 mifepristone multiple interactions ISO RGD:10796 6480464 Mifepristone inhibits the reaction [Ethanol results in decreased expression of IL4 mRNA] CTD PMID:7473187 morphine multiple interactions ISO RGD:10796 6480464 [FAS protein binds to FASL protein] affects the reaction [Morphine results in increased expression of IL4 protein] CTD PMID:16210602 morphine increases expression ISO RGD:10796 6480464 Morphine results in increased expression of IL4 protein CTD PMID:16210602 mycophenolic acid decreases expression ISO RGD:2898 6480464 Mycophenolic Acid results in decreased expression of IL4 mRNA CTD PMID:11562063 N-acetyl-beta-D-glucosamine increases expression ISO RGD:10796 6480464 Acetylglucosamine analog results in increased expression of IL4 mRNA CTD PMID:21349367 N-acetyl-D-glucosamine increases expression ISO RGD:10796 6480464 Acetylglucosamine analog results in increased expression of IL4 mRNA CTD PMID:21349367 N-methyl-N-nitrosurea multiple interactions ISO RGD:10796 6480464 Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of IL4 protein]; more ... CTD PMID:16822543 N-methyl-N-nitrosurea increases expression ISO RGD:10796 6480464 Methylnitrosourea results in increased expression of IL4 protein CTD PMID:16822543 naphthalene increases expression EXP   6480464 naphthalene results in increased expression of IL4 protein CTD PMID:12112628 naproxen multiple interactions ISO RGD:2898 6480464 [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of IL4 protein]; more ... CTD PMID:22150557 nickel dichloride multiple interactions EXP   6480464 [nickel chloride co-treated with Lipopolysaccharides] results in increased secretion of IL4 protein CTD PMID:18437699 nickel sulfate increases expression EXP   6480464 nickel sulfate results in increased expression of IL4 mRNA CTD PMID:11145678 nickel sulfate increases secretion EXP   6480464 nickel sulfate results in increased secretion of IL4 protein CTD PMID:10929769 nitric oxide multiple interactions EXP   6480464 IL4 protein inhibits the reaction [IL1B protein results in increased abundance of Nitric Oxide] CTD PMID:12115740 nitric oxide multiple interactions ISO RGD:10796 6480464 IL4 protein inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide] CTD PMID:12612912 nitroprusside decreases expression EXP   6480464 Nitroprusside results in decreased expression of IL4 mRNA CTD PMID:9201699 nitroprusside increases expression ISO RGD:10796 6480464 Nitroprusside results in increased expression of IL4 mRNA CTD PMID:16533816 nitroprusside multiple interactions ISO RGD:10796 6480464 Cyclosporine inhibits the reaction [Nitroprusside results in increased expression of IL4 mRNA] CTD PMID:16533816 nonanoic acid affects expression ISO RGD:10796 6480464 pelargonic acid affects the expression of IL4 mRNA CTD PMID:22302311 ozone multiple interactions ISO RGD:10796 6480464 IL4 protein affects the reaction [Ozone results in increased expression of CXCL5 mRNA] CTD PMID:18417511 paracetamol increases expression ISO RGD:10796 6480464 Acetaminophen results in increased expression of IL4 protein CTD PMID:11826401 paracetamol increases response to substance ISO RGD:10796 6480464 IL4 gene mutant form results in increased susceptibility to Acetaminophen CTD PMID:22107450 paracetamol multiple interactions ISO RGD:10796 6480464 IL4 gene mutant form promotes the reaction [Acetaminophen results in increased phosphorylation of MAPK8 protein]; more ... CTD PMID:22107450 paracetamol multiple interactions ISO RGD:10796 6480464 IL6 protein affects the reaction [IL4 protein affects the susceptibility to Acetaminophen] CTD PMID:17305405 paracetamol affects response to substance ISO RGD:10796 6480464 IL4 protein affects the susceptibility to Acetaminophen CTD PMID:17305405 parathion multiple interactions ISO RGD:10796 6480464 [Parathion co-treated with Antigens, Dermatophagoides] affects the expression of IL4 protein CTD PMID:21864637 parathion increases expression ISO RGD:10796 6480464 Parathion results in increased expression of IL4 mRNA; more ... CTD PMID:22842586 pentamidine multiple interactions ISO RGD:10796 6480464 [Pentamidine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL4 protein CTD PMID:15588918 perfluorooctane-1-sulfonic acid decreases secretion EXP   6480464 perfluorooctane sulfonic acid results in decreased secretion of IL4 protein CTD PMID:21075133 perfluorooctane-1-sulfonic acid increases secretion ISO RGD:10796 6480464 perfluorooctane sulfonic acid results in increased secretion of IL4 protein CTD PMID:21327619 perfluorooctanoic acid decreases secretion EXP   6480464 perfluorooctanoic acid results in decreased secretion of IL4 protein CTD PMID:21075133 phorbol 13-acetate 12-myristate multiple interactions EXP   6480464 Cyclosporine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL4 protein]; more ... CTD PMID:1371491 phorbol 13-acetate 12-myristate multiple interactions EXP   6480464 [Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL4 mRNA; more ... CTD PMID:21515303 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:10796 6480464 bisphenol A promotes the reaction [[[Tetradecanoylphorbol Acetate co-treated with Ionomycin] promotes the reaction [NFATC3 protein binds to IL4 promoter]] which results in increased expression of IL4 mRNA]; more ... CTD PMID:12709020 PMID:12709020 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:10796 6480464 Dimaprit inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL4 protein]; more ... CTD PMID:19277450 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:10796 6480464 bisphenol A promotes the reaction [[[Tetradecanoylphorbol Acetate co-treated with Ionomycin] promotes the reaction [NFATC3 protein binds to IL4 promoter]] which results in increased expression of IL4 mRNA]; more ... CTD PMID:12709020 phorbol 13-acetate 12-myristate multiple interactions EXP   6480464 [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of IL4 mRNA CTD PMID:16979875 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:10796 6480464 [Cyclosporine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL4 protein; more ... CTD PMID:15588918 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:10796 6480464 deoxynivalenol promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL4 mRNA]; more ... CTD PMID:8658534 phorbol 13-acetate 12-myristate increases expression EXP   6480464 Tetradecanoylphorbol Acetate results in increased expression of IL4 mRNA CTD PMID:10428506 phorbol 13-acetate 12-myristate multiple interactions EXP   6480464 [Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL4 protein CTD PMID:17572062 phorbol 13-acetate 12-myristate multiple interactions EXP   6480464 plant extract, Houttuynia cordata inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL4 protein] CTD PMID:18325701 phorbol 13-acetate 12-myristate multiple interactions EXP   6480464 Luteolin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL4] CTD PMID:16601352 phthalaldehyde affects expression ISO RGD:10796 6480464 o-Phthalaldehyde affects the expression of IL4 mRNA CTD PMID:22302311 phthalaldehyde increases expression ISO RGD:10796 6480464 o-Phthalaldehyde results in increased expression of IL4 mRNA CTD PMID:19110043 more ... phthalaldehyde increases expression ISO RGD:10796 6480464 o-Phthalaldehyde results in increased expression of IL4 protein CTD PMID:20176622 phthalaldehyde multiple interactions ISO RGD:10796 6480464 [o-Phthalaldehyde co-treated with SERPINB14 protein] results in increased expression of IL4 mRNA CTD PMID:19110043 phthalic anhydride increases expression ISO RGD:10796 6480464 phthalic anhydride results in increased expression of IL4 mRNA CTD PMID:14599759 PMID:10637130 phthalic anhydride increases expression ISO RGD:10796 6480464 phthalic anhydride results in increased expression of IL4 protein CTD PMID:19422874 PMID:20219652 phthalic anhydride increases expression ISO RGD:10796 6480464 phthalic anhydride results in increased expression of IL4 protein CTD PMID:20219652 PMID:19422874 phthalic anhydride increases expression ISO RGD:10796 6480464 phthalic anhydride results in increased expression of IL4 mRNA CTD PMID:10637130 PMID:14599759 phthalic anhydride increases expression ISO RGD:10796 6480464 phthalic anhydride results in increased expression of IL4 protein CTD PMID:20219652 phthalic anhydride increases expression EXP   6480464 phthalic anhydride results in increased expression of IL4 mRNA CTD PMID:21252390 pioglitazone multiple interactions ISO RGD:10796 6480464 pioglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein] CTD PMID:17015710 piperonyl butoxide multiple interactions EXP   6480464 [bioallethrin co-treated with Piperonyl Butoxide] results in increased expression of IL4 protein CTD PMID:10414782 piperonyl butoxide increases expression ISO RGD:10796 6480464 Piperonyl Butoxide results in increased expression of IL4 protein; more ... CTD PMID:22842586 pirinixic acid decreases expression ISO RGD:10796 6480464 pirinixic acid results in decreased expression of IL4 mRNA CTD PMID:18249437 PMID:17888025 pirinixic acid decreases expression ISO RGD:10796 6480464 pirinixic acid results in decreased expression of IL4 mRNA CTD PMID:17888025 PMID:18249437 pirinixic acid increases expression ISO RGD:2898 6480464 pirinixic acid results in increased expression of IL4 mRNA CTD PMID:19782605 pirinixic acid multiple interactions ISO RGD:10796 6480464 [Picryl Chloride co-treated with pirinixic acid] results in decreased expression of IL4 protein; more ... CTD PMID:17371993 prednisolone multiple interactions ISO RGD:10796 6480464 Prednisolone inhibits the reaction [Picryl Chloride results in increased expression of IL4 protein] CTD PMID:16442096 prednisolone decreases expression ISO RGD:10796 6480464 Prednisolone results in decreased expression of IL4 protein CTD PMID:15821026 prednisolone decreases expression EXP   6480464 Prednisolone results in decreased expression of IL4 protein CTD PMID:15821026 prednisone decreases expression EXP   6480464 Prednisone results in decreased expression of IL4 protein CTD PMID:19584951 progesterone decreases expression ISO RGD:10796 6480464 Progesterone results in decreased expression of IL4 protein CTD PMID:15804489 prostaglandin E2 increases secretion EXP   6480464 Dinoprostone results in increased secretion of IL4 protein CTD PMID:15788148 prostaglandin E2 multiple interactions EXP   6480464 [IL4 protein co-treated with CSF2 protein co-treated with TNF protein co-treated with Dinoprostone co-treated with IL1B protein co-treated with IL6 protein] results in increased expression of CCR7 protein; more ... CTD PMID:18952292 prostaglandin E2 decreases secretion EXP   6480464 IL4 results in decreased secretion of Dinoprostone CTD PMID:19767084 prostaglandin E2 increases response to substance ISO RGD:10796 6480464 IL4 protein results in increased susceptibility to Dinoprostone CTD PMID:12370375 pyrene increases expression EXP   6480464 pyrene results in increased expression of IL4 mRNA; more ... CTD PMID:10756232 pyrene increases expression ISO RGD:10796 6480464 pyrene results in increased expression of IL4 mRNA CTD PMID:10756232 pyruvic acid multiple interactions ISO RGD:2898 6480464 Pyruvic Acid inhibits the reaction [Mercuric Chloride results in increased expression of IL4 mRNA] CTD PMID:11222498 quercetin multiple interactions EXP   6480464 Quercetin inhibits the reaction [Calcimycin results in increased expression of IL4 mRNA] CTD PMID:12789233 quercetin increases expression EXP   6480464 Quercetin results in increased expression of IL4 mRNA; more ... CTD PMID:12431781 resveratrol affects expression ISO RGD:10796 6480464 resveratrol affects the expression of IL4 protein CTD PMID:20730501 resveratrol decreases expression ISO RGD:10796 6480464 resveratrol results in decreased expression of IL4 protein CTD PMID:22962611 retinyl acetate increases expression ISO RGD:10796 6480464 retinol acetate results in increased expression of IL4 protein CTD PMID:11444878 ribavirin decreases expression EXP   6480464 Ribavirin results in decreased expression of IL4 protein CTD PMID:10770762 ribavirin multiple interactions EXP   6480464 Ribavirin promotes the reaction [Lipopolysaccharides results in increased secretion of IL4 protein] CTD PMID:9722937 ricinoleic acid multiple interactions EXP   6480464 ricinoleic acid inhibits the reaction [IL4 protein results in increased expression of VCAM1 protein] CTD PMID:7544037 rolipram multiple interactions ISO RGD:10796 6480464 Rolipram inhibits the reaction [Picryl Chloride results in increased expression of IL4 protein] CTD PMID:16442096 rosiglitazone multiple interactions ISO RGD:10796 6480464 rosiglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein] CTD PMID:17015710 rosiglitazone multiple interactions ISO RGD:10796 6480464 rosiglitazone promotes the reaction [[Selenium co-treated with IL4 protein] results in increased activity of ARG1 protein] CTD PMID:21775527 rosiglitazone increases expression ISO RGD:2898 6480464 rosiglitazone results in increased expression of IL4 mRNA CTD PMID:17950491 rosiglitazone affects response to substance ISO RGD:10796 6480464 IL4 affects the susceptibility to rosiglitazone CTD PMID:17950491 rosiglitazone multiple interactions ISO RGD:10796 6480464 IL4 affects the reaction [rosiglitazone inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]] CTD PMID:17950491 rosiglitazone affects expression EXP   6480464 rosiglitazone affects the expression of IL4 protein CTD PMID:17445473 salicylic acid decreases secretion EXP   6480464 Salicylic Acid results in decreased secretion of IL4 protein CTD PMID:11238116 salicylic acid decreases expression EXP   6480464 Salicylic Acid results in decreased expression of IL4 mRNA CTD PMID:11238116 selenium atom decreases expression ISO RGD:10796 6480464 Selenium results in decreased expression of IL4 protein CTD PMID:14624943 selenium atom multiple interactions ISO RGD:10796 6480464 Selenium deficiency inhibits the reaction [IL4 protein results in increased expression of GPX1 protein]; more ... CTD PMID:21775527 selenium atom multiple interactions ISO RGD:2898 6480464 [Vanadium co-treated with Selenium co-treated with Vitamin E co-treated with Chromium] results in increased expression of IL4 protein CTD PMID:15862027 serotonin affects response to substance ISO RGD:10796 6480464 IL4 protein affects the susceptibility to Serotonin CTD PMID:12370375 sildenafil multiple interactions ISO RGD:10796 6480464 sildenafil inhibits the reaction [4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone results in decreased expression of IL4 protein] CTD PMID:15169552 silicon dioxide increases secretion ISO RGD:10796 6480464 Silicon Dioxide results in increased secretion of IL4 protein CTD PMID:20490462 silicon dioxide multiple interactions ISO RGD:10796 6480464 IL6RA mRNA affects the reaction [Silicon Dioxide results in increased expression of IL4 mRNA] CTD PMID:20490462 silicon dioxide increases expression ISO RGD:10796 6480464 Silicon Dioxide results in increased expression of IL4 mRNA CTD PMID:20490462 silver(1+) nitrate affects response to substance ISO RGD:10796 6480464 IL4 protein affects the susceptibility to Silver Nitrate CTD PMID:19077085 silver(1+) nitrate multiple interactions ISO RGD:10796 6480464 IL4 protein affects the reaction [Silver Nitrate results in decreased activity of FBL protein] CTD PMID:19077085 simvastatin multiple interactions EXP   6480464 IL4 affects the reaction [Simvastatin results in decreased expression of IL17A mRNA]; more ... CTD PMID:18453621 simvastatin decreases expression ISO RGD:10796 6480464 Simvastatin results in decreased expression of IL4 mRNA; more ... CTD PMID:17169357 simvastatin increases secretion EXP   6480464 Simvastatin results in increased secretion of IL4 protein CTD PMID:18453621 simvastatin increases expression EXP   6480464 Simvastatin results in increased expression of IL4 mRNA CTD PMID:18453621 sirolimus multiple interactions ISO RGD:10796 6480464 [Sirolimus co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL4 protein CTD PMID:15588918 sirolimus decreases expression ISO RGD:10796 6480464 Sirolimus results in decreased expression of IL4 protein CTD PMID:15588918 sirolimus multiple interactions ISO RGD:10796 6480464 Sirolimus inhibits the reaction [IL4 protein results in increased expression of [IL12A protein binds to IL12B protein]] CTD PMID:12531798 sirolimus decreases expression ISO RGD:10796 6480464 Sirolimus analog results in decreased expression of IL4 protein CTD PMID:12406821 sodium aurothiomalate multiple interactions ISO RGD:10796 6480464 IL4 protein affects the reaction [Gold Sodium Thiomalate results in decreased activity of FBL protein] CTD PMID:19077085 sodium aurothiomalate affects response to substance ISO RGD:10796 6480464 IL4 protein affects the susceptibility to Gold Sodium Thiomalate CTD PMID:19077085 sodium dichromate decreases expression ISO RGD:2898 6480464 sodium bichromate results in decreased expression of IL4 protein CTD PMID:22011396 sodium dodecyl sulfate multiple interactions ISO RGD:10796 6480464 [diethylamine co-treated with Sodium Dodecyl Sulfate] results in increased expression of IL4 protein; more ... CTD PMID:12062936 sodium hexachloroplatinate increases expression ISO RGD:10796 6480464 disodium hexachloroplatinate results in increased expression of IL4 protein CTD PMID:22381623 styrene decreases expression ISO RGD:10796 6480464 Styrene results in decreased expression of IL4 protein CTD PMID:16879906 sumatriptan multiple interactions ISO RGD:2898 6480464 [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of IL4 protein]; more ... CTD PMID:22150557 tacrolimus hydrate multiple interactions EXP   6480464 Tacrolimus inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL4 protein] CTD PMID:1371491 tacrolimus hydrate decreases expression ISO RGD:2898 6480464 Tacrolimus results in decreased expression of IL4 protein CTD PMID:10685002 tacrolimus hydrate decreases expression ISO RGD:2898 6480464 Tacrolimus results in decreased expression of IL4 mRNA CTD PMID:16368244 tacrolimus hydrate decreases expression EXP   6480464 Tacrolimus results in decreased expression of IL4 protein CTD PMID:11407316 tacrolimus hydrate multiple interactions ISO RGD:10796 6480464 Tacrolimus inhibits the reaction [bisphenol A promotes the reaction [NFATC3 protein binds to IL4 promoter]]; more ... CTD PMID:12709020 tamibarotene multiple interactions ISO RGD:2898 6480464 Am 80 inhibits the reaction [dinitrophenyl-human serum albumin conjugate results in increased expression of IL4 protein]; more ... CTD PMID:11233995 tamoxifen decreases expression EXP   6480464 Tamoxifen results in decreased expression of IL4 mRNA CTD PMID:15590111 tamoxifen increases expression ISO RGD:10796 6480464 Tamoxifen results in increased expression of IL4 mRNA; more ... CTD PMID:19031437 tamoxifen affects expression ISO RGD:10796 6480464 Tamoxifen affects the expression of IL4 mRNA CTD PMID:17555576 tetrachloroethene increases expression ISO RGD:2898 6480464 Tetrachloroethylene results in increased expression of IL4 mRNA CTD PMID:18721841 tetrachloroethene increases expression ISO RGD:2898 6480464 Tetrachloroethylene results in increased expression of IL4 protein CTD PMID:18006135 PMID:18950594 tetrachloroethene increases expression ISO RGD:2898 6480464 Tetrachloroethylene results in increased expression of IL4 protein CTD PMID:18950594 PMID:18006135 tetrachloromethane increases expression ISO RGD:10796 6480464 Carbon Tetrachloride results in increased expression of IL4 protein CTD PMID:17038628 more ... tetrachloromethane increases expression ISO RGD:10796 6480464 Carbon Tetrachloride results in increased expression of IL4 protein CTD PMID:18279442 more ... tetrachloromethane increases expression ISO RGD:10796 6480464 Carbon Tetrachloride results in increased expression of IL4 protein CTD PMID:17038628 more ... tetrachloromethane multiple interactions ISO RGD:2898 6480464 phenylmethylpyrazolone inhibits the reaction [Carbon Tetrachloride results in increased expression of IL4 mRNA] CTD PMID:14567445 tetrachloromethane increases expression ISO RGD:2898 6480464 Carbon Tetrachloride results in increased expression of IL4 mRNA CTD PMID:14567445 tetrachloromethane increases expression ISO RGD:10796 6480464 Carbon Tetrachloride results in increased expression of IL4 protein CTD PMID:17412915 more ... tetrachloromethane multiple interactions ISO RGD:10796 6480464 PLAT protein affects the reaction [Carbon Tetrachloride results in increased expression of IL4 protein]; more ... CTD PMID:18279442 tetrachloromethane multiple interactions ISO RGD:10796 6480464 IL1RL1 protein affects the reaction [Carbon Tetrachloride results in increased expression of IL4 protein] CTD PMID:17412915 tetrachloromethane multiple interactions ISO RGD:10796 6480464 copolymer 1 inhibits the reaction [Carbon Tetrachloride results in increased expression of IL4 protein] CTD PMID:17038628 thalidomide increases expression ISO RGD:2898 6480464 Thalidomide results in increased expression of IL4 protein CTD PMID:16078585 thapsigargin multiple interactions ISO RGD:10796 6480464 Thapsigargin inhibits the reaction [bisphenol A results in increased expression of IL4 protein]; more ... CTD PMID:12709020 theophylline multiple interactions EXP   6480464 IL4 protein inhibits the reaction [[Theophylline co-treated with Chlorambucil] results in increased expression of MYC protein]; more ... CTD PMID:8822937 theophylline decreases expression EXP   6480464 Theophylline results in decreased expression of IL4 mRNA CTD PMID:10596698 theophylline decreases secretion ISO RGD:10796 6480464 Theophylline results in decreased secretion of IL4 protein CTD PMID:11694023 thiram increases expression ISO RGD:10796 6480464 Thiram results in increased expression of IL4 protein CTD PMID:12062936 titanium dioxide increases expression EXP   6480464 titanium dioxide results in increased expression of IL4 mRNA CTD PMID:19695317 toluene multiple interactions ISO RGD:10796 6480464 [SERPINB14 protein co-treated with Toluene] results in increased expression of IL4 mRNA CTD PMID:21601613 toluene 2,4-diisocyanate multiple interactions ISO RGD:10796 6480464 4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; more ... CTD PMID:12789230 toluene 2,4-diisocyanate increases secretion ISO RGD:10796 6480464 Toluene 2,4-Diisocyanate results in increased secretion of IL4 protein CTD PMID:17693426 toluene 2,4-diisocyanate increases expression EXP   6480464 Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA CTD PMID:20371970 toluene 2,4-diisocyanate increases expression ISO RGD:10796 6480464 Toluene 2,4-Diisocyanate results in increased expression of IL4 protein CTD PMID:12789230 more ... toluene 2,4-diisocyanate increases secretion EXP   6480464 Toluene 2,4-Diisocyanate results in increased secretion of IL4 protein CTD PMID:20371970 toluene 2,4-diisocyanate multiple interactions EXP   6480464 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL4 protein] CTD PMID:20371970 toluene 2,4-diisocyanate increases expression ISO RGD:10796 6480464 Toluene 2,4-Diisocyanate results in increased expression of IL4 protein CTD PMID:12789230 more ... toluene 2,4-diisocyanate increases expression ISO RGD:10796 6480464 Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA CTD PMID:10637130 more ... toluene 2,4-diisocyanate increases expression ISO RGD:10796 6480464 Toluene 2,4-Diisocyanate results in increased expression of IL4 protein CTD PMID:12789230 more ... toluene 2,4-diisocyanate increases expression ISO RGD:10796 6480464 Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA CTD PMID:11467998 more ... toluene 2,4-diisocyanate affects secretion ISO RGD:10796 6480464 Toluene 2,4-Diisocyanate affects the secretion of IL4 protein CTD PMID:19150644 toluene 2,4-diisocyanate increases expression ISO RGD:2898 6480464 Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA CTD PMID:19050374 PMID:19075512 toluene 2,4-diisocyanate increases expression ISO RGD:10796 6480464 Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA CTD PMID:11467998 more ... toluene 2,4-diisocyanate increases expression ISO RGD:10796 6480464 Toluene 2,4-Diisocyanate results in increased expression of IL4 protein CTD PMID:12956900 more ... toluene 2,4-diisocyanate increases expression ISO RGD:2898 6480464 Toluene 2,4-Diisocyanate results in increased expression of IL4 protein CTD PMID:11758997 PMID:15950818 toluene 2,4-diisocyanate increases expression ISO RGD:10796 6480464 Toluene 2,4-Diisocyanate results in increased expression of IL4 protein CTD PMID:12956900 more ... toluene 2,4-diisocyanate increases expression ISO RGD:10796 6480464 Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA CTD PMID:11467998 more ... toluene 2,4-diisocyanate increases expression ISO RGD:10796 6480464 Toluene 2,4-Diisocyanate results in increased expression of IL4 protein CTD PMID:12956900 more ... toluene 2,4-diisocyanate increases expression ISO RGD:10796 6480464 Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA CTD PMID:16210060 more ... toluene 2,4-diisocyanate increases expression ISO RGD:10796 6480464 Toluene 2,4-Diisocyanate results in increased expression of IL4 protein CTD PMID:16271432 more ... toluene 2,4-diisocyanate increases expression ISO RGD:10796 6480464 Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA CTD PMID:18652873 more ... toluene 2,4-diisocyanate increases expression ISO RGD:2898 6480464 Toluene 2,4-Diisocyanate results in increased expression of IL4 protein CTD PMID:15950818 PMID:11758997 toluene 2,4-diisocyanate increases expression ISO RGD:2898 6480464 Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA CTD PMID:19075512 PMID:19050374 toluene 2,4-diisocyanate multiple interactions ISO RGD:2898 6480464 sho-seiryu-to inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA] CTD PMID:19050374 toluene 2,4-diisocyanate multiple interactions ISO RGD:2898 6480464 Chlorpheniramine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]; more ... CTD PMID:19075512 toluene 2,4-diisocyanate increases expression ISO RGD:10796 6480464 Toluene 2,4-Diisocyanate results in increased expression of IL4 protein CTD PMID:12789230 more ... toluene 2,4-diisocyanate multiple interactions ISO RGD:10796 6480464 [Toluene 2,4-Diisocyanate co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL4 protein CTD PMID:15588918 toluene 2,4-diisocyanate increases expression ISO RGD:10796 6480464 Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA CTD PMID:11467998 more ... toluene 2,4-diisocyanate multiple interactions ISO RGD:10796 6480464 TNF protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA] CTD PMID:12356572 toluene 2,4-diisocyanate multiple interactions ISO RGD:10796 6480464 ICAM1 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein] CTD PMID:17014439 toluene 2,4-diisocyanate multiple interactions ISO RGD:10796 6480464 IL1A protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]; more ... CTD PMID:16210060 toluene 2,4-diisocyanate multiple interactions ISO RGD:10796 6480464 CD4 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA] CTD PMID:15590890 toluene 2,4-diisocyanate multiple interactions ISO RGD:10796 6480464 BAY 11-7085 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; more ... CTD PMID:17015710 toluene 2,4-diisocyanate multiple interactions ISO RGD:10796 6480464 AWD 12-281 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; more ... CTD PMID:12956900 trans-resveratrol affects expression ISO RGD:10796 6480464 resveratrol affects the expression of IL4 protein CTD PMID:20730501 trans-resveratrol decreases expression ISO RGD:10796 6480464 resveratrol results in decreased expression of IL4 protein CTD PMID:22962611 trichloroethene increases response to substance EXP   6480464 IL4 gene polymorphism results in increased susceptibility to Trichloroethylene CTD PMID:19351467 trichloroethene decreases secretion ISO RGD:10796 6480464 Trichloroethylene results in decreased secretion of IL4 protein CTD PMID:22407948 trichloroethene decreases expression ISO RGD:10796 6480464 Trichloroethylene results in decreased expression of IL4 mRNA CTD PMID:22407948 trichloroethene increases expression ISO RGD:2898 6480464 Trichloroethylene results in increased expression of IL4 protein CTD PMID:18006135 trichloroethene increases expression ISO RGD:10796 6480464 Trichloroethylene results in increased expression of IL4 mRNA CTD PMID:15363585 trichloroethene decreases expression ISO RGD:10796 6480464 Trichloroethylene results in decreased expression of IL4 protein CTD PMID:10774820 trichloroethene multiple interactions ISO RGD:10796 6480464 allyl sulfide inhibits the reaction [Trichloroethylene results in decreased expression of IL4 protein] CTD PMID:10774820 trimellitic anhydride increases expression EXP   6480464 trimellitic anhydride results in increased expression of IL4 mRNA CTD PMID:21252390 trimellitic anhydride increases expression ISO RGD:10796 6480464 trimellitic anhydride results in increased expression of IL4 protein CTD PMID:12884401 more ... trimellitic anhydride increases expression ISO RGD:10796 6480464 trimellitic anhydride results in increased expression of IL4 protein CTD PMID:12884401 more ... trimellitic anhydride increases expression ISO RGD:10796 6480464 trimellitic anhydride results in increased expression of IL4 mRNA CTD PMID:10637130 more ... trimellitic anhydride increases expression ISO RGD:10796 6480464 trimellitic anhydride results in increased expression of IL4 protein CTD PMID:12884401 more ... trimellitic anhydride increases expression ISO RGD:10796 6480464 trimellitic anhydride results in increased expression of IL4 mRNA CTD PMID:10637130 more ... trimellitic anhydride increases expression ISO RGD:10796 6480464 trimellitic anhydride results in increased expression of IL4 mRNA CTD PMID:11708898 more ... trimellitic anhydride increases expression ISO RGD:10796 6480464 trimellitic anhydride results in increased expression of IL4 protein CTD PMID:19042193 more ... trimellitic anhydride increases expression ISO RGD:10796 6480464 trimellitic anhydride results in increased expression of IL4 protein CTD PMID:19042193 more ... trimellitic anhydride increases expression ISO RGD:10796 6480464 trimellitic anhydride results in increased expression of IL4 mRNA CTD PMID:14599759 more ... trimellitic anhydride increases expression ISO RGD:10796 6480464 trimellitic anhydride results in increased expression of IL4 mRNA CTD PMID:10637130 more ... trimellitic anhydride affects expression ISO RGD:10796 6480464 trimellitic anhydride affects the expression of IL4 mRNA CTD PMID:22302311 trimellitic anhydride increases expression ISO RGD:10796 6480464 trimellitic anhydride results in increased expression of IL4 protein CTD PMID:20219652 more ... trimellitic anhydride increases expression ISO RGD:10796 6480464 trimellitic anhydride results in increased expression of IL4 mRNA CTD PMID:19042947 more ... trimellitic anhydride increases secretion ISO RGD:10796 6480464 trimellitic anhydride results in increased secretion of IL4 protein CTD PMID:15588915 trimellitic anhydride increases expression ISO RGD:10796 6480464 trimellitic anhydride results in increased expression of IL4 protein CTD PMID:12884401 more ... trimellitic anhydride increases expression ISO RGD:10796 6480464 trimellitic anhydride results in increased expression of IL4 mRNA CTD PMID:14599759 more ... urethane multiple interactions ISO RGD:10796 6480464 Freund's Adjuvant inhibits the reaction [Urethane results in decreased expression of IL4 mRNA]; more ... CTD PMID:12810352 urethane decreases expression ISO RGD:10796 6480464 Urethane results in decreased expression of IL4 mRNA CTD PMID:12810352 vanadium atom multiple interactions ISO RGD:2898 6480464 [Vanadium co-treated with Selenium co-treated with Vitamin E co-treated with Chromium] results in increased expression of IL4 protein CTD PMID:15862027 vanadium(0) multiple interactions ISO RGD:2898 6480464 [Vanadium co-treated with Selenium co-treated with Vitamin E co-treated with Chromium] results in increased expression of IL4 protein CTD PMID:15862027 verrucarin A affects secretion ISO RGD:10796 6480464 muconomycin A affects the secretion of IL4 protein CTD PMID:8560498 verrucarin A increases expression ISO RGD:10796 6480464 muconomycin A results in increased expression of IL4 mRNA CTD PMID:8560498 zinc atom decreases expression ISO RGD:10796 6480464 Zinc results in decreased expression of IL4 protein CTD PMID:14624943 zinc atom multiple interactions EXP   6480464 [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of IL4 mRNA CTD PMID:16979875 zinc(0) decreases expression ISO RGD:10796 6480464 Zinc results in decreased expression of IL4 protein CTD PMID:14624943 zinc(0) multiple interactions EXP   6480464 [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of IL4 mRNA CTD PMID:16979875 Gene Ontology Annotations Biological Process Term Qualifier Evidence With Reference Notes Source Original Reference(s) B cell costimulation   IEA Ensembl:ENSMUSP00000000889 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 B cell differentiation   TAS   2290271 PMID:11418631 UniProtKB PMID:11418631 cellular defense response   TAS   2290271 PMID:10725748 PINC PMID:10725748 cellular response to mercury ion   IEA Ensembl:ENSRNOP00000010029 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 chemotaxis   TAS   2290271 PMID:10725748 PINC PMID:10725748 cholesterol metabolic process   ISS UniProtKB:P07750 2290271 PMID:11971948 UniProtKB PMID:11971948 connective tissue growth factor biosynthetic process   TAS   2290271 PMID:11967989 UniProtKB PMID:11967989 dendritic cell differentiation   IDA   2290271 PMID:21149635 DFLAT PMID:21149635 female pregnancy   IEA Ensembl:ENSRNOP00000010029 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 immune response   TAS   2290271 PMID:3016727 PINC PMID:3016727 innate immune response in mucosa   IEA Ensembl:ENSMUSP00000000889 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 negative regulation of acute inflammatory response   IEA Ensembl:ENSRNOP00000010029 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 negative regulation of apoptotic process   ISS UniProtKB:P07750 2290271 GO_REF:0000024 UniProtKB GO_REF:0000024 negative regulation of chronic inflammatory response   IEA Ensembl:ENSRNOP00000010029 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 negative regulation of macrophage activation   IEA Ensembl:ENSRNOP00000010029 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 negative regulation of nitric oxide biosynthetic process   IEA Ensembl:ENSRNOP00000010029 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 negative regulation of osteoclast differentiation   ISS UniProtKB:P07750 2290271 GO_REF:0000024 UniProtKB GO_REF:0000024 negative regulation of T-helper 17 cell differentiation   IEA Ensembl:ENSMUSP00000000889 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 negative regulation of transcription, DNA-dependent   IDA   2290271 PMID:18579517 UniProtKB PMID:18579517 positive regulation of activated T cell proliferation   IEA Ensembl:ENSMUSP00000000889 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of B cell proliferation   ISS UniProtKB:P07750 2290271 GO_REF:0000024 UniProtKB GO_REF:0000024 positive regulation of chemokine biosynthetic process   IEA Ensembl:ENSMUSP00000000889 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of interleukin-10 production   IEA Ensembl:ENSRNOP00000010029 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of interleukin-13 production   IDA   2290271 PMID:19346497 UniProtKB PMID:19346497 positive regulation of isotype switching to IgE isotypes   ISS UniProtKB:P07750 2290271 GO_REF:0000024 UniProtKB GO_REF:0000024 positive regulation of isotype switching to IgG isotypes   ISS UniProtKB:P07750 2290271 GO_REF:0000024 UniProtKB GO_REF:0000024 positive regulation of MHC class II biosynthetic process   ISS UniProtKB:P07750 2290271 GO_REF:0000024 UniProtKB GO_REF:0000024 positive regulation of sequence-specific DNA binding transcription factor activity   IEA Ensembl:ENSMUSP00000000889 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of T cell differentiation   IDA   2290271 PMID:20554961 UniProtKB PMID:20554961 positive regulation of T cell proliferation   ISS UniProtKB:P07750 2290271 GO_REF:0000024 UniProtKB GO_REF:0000024 positive regulation of transcription from RNA polymerase II promoter   ISS UniProtKB:P07750 2290271 GO_REF:0000024 UniProtKB GO_REF:0000024 positive regulation of transcription, DNA-dependent   IDA   2290271 PMID:18579517 UniProtKB PMID:18579517 positive regulation of transcription, DNA-dependent   IDA   2290271 PMID:20554961 UniProtKB PMID:20554961 positive regulation of transcription, DNA-dependent   IDA   2290271 PMID:19346497 UniProtKB PMID:19346497 positive regulation of tyrosine phosphorylation of Stat5 protein   IEA Ensembl:ENSMUSP00000000889 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 regulation of immune response   ISS UniProtKB:P07750 2290271 GO_REF:0000024 UniProtKB GO_REF:0000024 regulation of isotype switching   TAS   2290271 PMID:11418631 UniProtKB PMID:11418631 regulation of phosphorylation   ISS UniProtKB:P07750 2290271 GO_REF:0000024 UniProtKB GO_REF:0000024 regulation of proton transport   IEA Ensembl:ENSRNOP00000010029 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 response to cytokine stimulus   IEA Ensembl:ENSRNOP00000010029 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 response to drug   IEA Ensembl:ENSRNOP00000010029 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 response to ethanol   IEA Ensembl:ENSRNOP00000010029 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 response to nutrient   IEA Ensembl:ENSRNOP00000010029 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 response to organic cyclic compound   IEA Ensembl:ENSRNOP00000010029 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 T-helper 1 cell lineage commitment   IEA Ensembl:ENSMUSP00000000889 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 T-helper 2 cell cytokine production   IDA   2290271 PMID:20554961 UniProtKB PMID:20554961 T-helper 2 cell differentiation   IEA Ensembl:ENSMUSP00000000889 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 type 2 immune response   TAS   2290271 PMID:11676128 UniProtKB PMID:11676128 Cellular Component Term Qualifier Evidence With Reference Notes Source Original Reference(s) external side of plasma membrane   IEA Ensembl:ENSMUSP00000000889 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 extracellular space   TAS   2290271 PMID:11418631 UniProtKB PMID:11418631 Molecular Function Term Qualifier Evidence With Reference Notes Source Original Reference(s) cytokine activity   IEA Ensembl:ENSMUSP00000000889 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 growth factor activity   NAS   2290271 PMID:11418631 UniProtKB PMID:11418631 interleukin-4 receptor binding   TAS   2290271 PMID:11418631 UniProtKB PMID:11418631 protein binding   IPI UniProtKB:P24394 2290271 PMID:10219247 IntAct PMID:10219247 protein binding   IPI UniProtKB:P24394 2290271 PMID:8266078 IntAct PMID:8266078 protein binding   IPI UniProtKB:P78552 2290271 PMID:18243101 IntAct PMID:18243101 protein binding   IPI UniProtKB:P24394 2290271 PMID:18243101 IntAct PMID:18243101 Molecular Pathway Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) allograft rejection pathway   IEA RGD:736306 6907045   KEGG hsa:05330 asthma disease pathway   IEA RGD:736306 6907045   KEGG hsa:05310 autoimmune thyroid disease pathway   IEA RGD:736306 6907045   KEGG hsa:05320 interleukin-12 signaling pathway   EXP   6484113   PID PID:200045 interleukin-4 signaling pathway   EXP   6484113   PID PID:200022 Jak-Stat signaling pathway   IEA RGD:736306 6907045   KEGG hsa:04630 Leishmania infection pathway   IEA RGD:736306 6907045   KEGG hsa:05140 measles infection pathway   IEA RGD:736306 6907045   KEGG hsa:05162 Notch signaling pathway   EXP   6484113   PID PID:200015 T cell receptor signaling pathway   IEA RGD:736306 6907045   KEGG hsa:04660 External Database Links KEGG Pathway Allograft rejection Asthma Autoimmune thyroid disease Cytokine-cytokine receptor interaction Fc epsilon RI signaling pathway Hematopoietic cell lineage Intestinal immune network for IgA production Jak-STAT signaling pathway Leishmaniasis Measles PI3K-Akt signaling pathway T cell receptor signaling pathway Pathway Interaction Database AP-1 transcription factor network (PID:200137) Calcineurin-regulated NFAT-dependent transcription in lymphocytes (PID:200050) Calcium signaling in the CD4+ TCR pathway (PID:200185) CD40/CD40L signaling (PID:200037) Glucocorticoid receptor regulatory network (PID:200091) IL12-mediated signaling events (PID:200045) IL2 signaling events mediated by STAT5 (PID:200184) IL4-mediated signaling events (PID:200022) Notch signaling pathway (PID:200015) Phenotype Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) abnormal motor capabilities/coordination/movement   IAGP   1358745   RGD   Disease Annotations Anti-Glomerular Basement Membrane Disease  (ISS) Arthritis, Experimental  (ISS) Asthma  (IAGP,ISS) Behcet Syndrome  (IAGP) Biliary Tract Neoplasms  (IPM) Bronchiolitis Obliterans  (ISS) Carcinoma, Pancreatic Ductal  (IPM) Cholestasis  (ISS) Common Cold  (ISS) Cystitis  (ISS) Dermatitis, Irritant  (ISS) Gaucher Disease  (ISS) Hypertension, Pulmonary  (ISS) Influenza, Human  (ISS) Multiple Sclerosis  (IAGP) Nematode Infections  (ISS) Nephritis  (ISS) Osteoarthritis, Knee  (ISS) Otitis Media with Effusion  (ISS) Pancreatic Neoplasms  (IEP,IPM,ISS) Pulmonary Fibrosis  (ISS) Respiratory Hypersensitivity  (ISS) Respiratory Tract Infections  (IEP) Rhinitis  (ISS) Rhinitis, Allergic, Perennial  (IEP) Spinal Cord Injuries  (ISS) Tuberculosis, Pulmonary  (ISS) Gene-Chemical Interaction Annotations (+)-trans-(S)-allethrin  (EXP) 1,3,5-trinitrobenzene  (ISO) 1,4-phenylenediamine  (ISO) 1-chloro-2,4,6-trinitrobenzene  (EXP,ISO) 1-chloro-2,4-dinitrobenzene  (ISO) 17alpha-ethynylestradiol  (ISO) 17beta-estradiol  (ISO) 2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9-hexadecafluorononanoic acid  (ISO) 2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO) 2,4,6-trinitrobenzenesulfonic acid  (ISO) 2,4-D  (ISO) 2,6-di-tert-butyl-4-methylphenol  (ISO) 2-amino-2-deoxy-D-glucopyranose  (EXP,ISO) 3,3',5,5'-tetrabromobisphenol A  (ISO) 3H-1,2-dithiole-3-thione  (ISO) 4,4'-diaminodiphenylmethane  (EXP) 4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO) 4-ethylphenol  (ISO) 4-nonylphenol  (EXP) 4-tolyl isocyanate  (ISO) 5-azacytidine  (EXP) 6alpha-methylprednisolone  (EXP) 8-bromo-3',5'-cyclic AMP  (EXP) 8-bromo-3',5'-cyclic GMP  (ISO) 9-cis-retinoic acid  (EXP) acetaldehyde  (EXP) acetone  (EXP) acetylsalicylic acid  (EXP) acrylic acid  (ISO) alclometasone dipropionate  (EXP) aldehydo-D-glucosamine  (EXP,ISO) all-trans-retinoic acid  (EXP,ISO) all-trans-retinol  (ISO) alpha-hexylcinnamaldehyde  (ISO) alpha-linolenic acid  (EXP) aluminium atom  (ISO) aluminium hydroxide  (EXP,ISO) aluminium(0)  (ISO) ammonium chloride  (ISO) apigenin  (EXP) arachidonic acid  (EXP) asbestos  (ISO) azathioprine  (EXP) BAPTA  (EXP) benzene  (EXP) benzo[a]pyrene  (EXP,ISO) berberine  (ISO) beta-D-glucosamine  (EXP,ISO) betamethasone valerate  (EXP) bifenthrin  (ISO) biochanin A  (ISO) bis(2-chloroethyl) sulfide  (ISO) bis(2-ethylhexyl) phthalate  (EXP,ISO) bisphenol A  (EXP,ISO) bleomycin A2  (ISO) budesonide  (ISO) cadmium atom  (ISO) calcitriol  (ISO) calcium atom  (ISO) calcium(0)  (ISO) capsaicin  (ISO) carbachol  (ISO) carbon monoxide  (ISO) cetirizine  (ISO) chlorambucil  (EXP) chloroform  (ISO) chlorphenamine  (ISO) chromium atom  (ISO) chromium(6+)  (EXP) cilostazol  (ISO) ciprofloxacin  (EXP) cis-ketoconazole  (EXP) cisplatin  (EXP) cladribine  (EXP) clarithromycin  (EXP) cobalt atom  (EXP) cobalt dichloride  (ISO) cocaine  (EXP) curcumin  (ISO) cyclophosphamide  (ISO) cyclosporin A  (EXP,ISO) D-penicillamine  (ISO) daidzein  (ISO) dasatinib (anhydrous)  (ISO) DDE  (EXP) DDT  (EXP) Delta(9)-tetrahydrocannabinol  (EXP,ISO) desferrioxamine B  (ISO) dexamethasone  (EXP,ISO) diarsenic trioxide  (EXP,ISO) diazinon  (ISO) dibenzothiazol-2-yl disulfide  (ISO) diclofenac  (EXP) dicloxacillin  (ISO) dicyclohexylmethane-4,4'-diisocyanate  (ISO) diflorasone diacetate  (ISO) diisononyl phthalate  (ISO) dioxygen  (ISO) diphenylmethane-4,4'-diisocyanate  (ISO) dydrogesterone  (EXP,ISO) edaravone  (ISO) elemental selenium  (ISO) emodin  (ISO) epinastine  (EXP,ISO) estriol  (ISO) ethanol  (ISO) etoposide  (EXP) famotidine  (ISO) ferric oxide  (ISO) fisetin  (EXP) fluoranthene  (EXP) fomepizole  (ISO) formaldehyde  (ISO) formononetin  (ISO) furfuryl alcohol  (ISO) gadodiamide hydrate  (EXP) gadolinium trichloride  (EXP) genistein  (ISO) glutathione  (EXP,ISO) heptadecafluorononanoic acid  (ISO) heroin  (EXP) hesperidin  (ISO) hexachlorobenzene  (ISO) hexamethylene diisocyanate  (ISO) histamine  (ISO) hydrogen peroxide  (ISO) hydroquinone  (ISO) hydroxyzine  (ISO) ibuprofen  (ISO) indomethacin  (EXP,ISO) ionomycin  (EXP,ISO) isophorone diisocyanate  (ISO) isotretinoin  (ISO) itraconazole  (EXP) kaempferol  (EXP) L-ascorbic acid  (ISO) lead diacetate  (ISO) leflunomide  (EXP,ISO) leukotriene B4  (EXP) lidocaine  (ISO) lithium atom  (ISO) luteolin  (EXP,ISO) LY294002  (ISO) mercury atom  (ISO) mercury dichloride  (EXP,ISO) mercury(0)  (ISO) methanol  (ISO) methotrexate  (EXP) methoxychlor  (ISO) methyl isocyanate  (EXP) methyl salicylate  (ISO) miconazole  (EXP) mifepristone  (EXP,ISO) morphine  (ISO) mycophenolic acid  (ISO) N-acetyl-beta-D-glucosamine  (ISO) N-acetyl-D-glucosamine  (ISO) N-methyl-N-nitrosurea  (ISO) naphthalene  (EXP) naproxen  (ISO) nickel dichloride  (EXP) nickel sulfate  (EXP) nitric oxide  (EXP,ISO) nitroprusside  (EXP,ISO) nonanoic acid  (ISO) ozone  (ISO) paracetamol  (ISO) parathion  (ISO) pentamidine  (ISO) perfluorooctane-1-sulfonic acid  (EXP,ISO) perfluorooctanoic acid  (EXP) phorbol 13-acetate 12-myristate  (EXP,ISO) phthalaldehyde  (ISO) phthalic anhydride  (EXP,ISO) pioglitazone  (ISO) piperonyl butoxide  (EXP,ISO) pirinixic acid  (ISO) prednisolone  (EXP,ISO) prednisone  (EXP) progesterone  (ISO) prostaglandin E2  (EXP,ISO) pyrene  (EXP,ISO) pyruvic acid  (ISO) quercetin  (EXP) resveratrol  (ISO) retinyl acetate  (ISO) ribavirin  (EXP) ricinoleic acid  (EXP) rolipram  (ISO) rosiglitazone  (EXP,ISO) salicylic acid  (EXP) selenium atom  (ISO) serotonin  (ISO) sildenafil  (ISO) silicon dioxide  (ISO) silver(1+) nitrate  (ISO) simvastatin  (EXP,ISO) sirolimus  (ISO) sodium aurothiomalate  (ISO) sodium dichromate  (ISO) sodium dodecyl sulfate  (ISO) sodium hexachloroplatinate  (ISO) styrene  (ISO) sumatriptan  (ISO) tacrolimus hydrate  (EXP,ISO) tamibarotene  (ISO) tamoxifen  (EXP,ISO) tetrachloroethene  (ISO) tetrachloromethane  (ISO) thalidomide  (ISO) thapsigargin  (ISO) theophylline  (EXP,ISO) thiram  (ISO) titanium dioxide  (EXP) toluene  (ISO) toluene 2,4-diisocyanate  (EXP,ISO) trans-resveratrol  (ISO) trichloroethene  (EXP,ISO) trimellitic anhydride  (EXP,ISO) urethane  (ISO) vanadium atom  (ISO) vanadium(0)  (ISO) verrucarin A  (ISO) zinc atom  (EXP,ISO) zinc(0)  (EXP,ISO) Gene Ontology Annotations Biological Process B cell costimulation  (IEA) B cell differentiation  (TAS) cellular defense response  (TAS) cellular response to mercury ion  (IEA) chemotaxis  (TAS) cholesterol metabolic process  (ISS) connective tissue growth factor biosynthetic process  (TAS) dendritic cell differentiation  (IDA) female pregnancy  (IEA) immune response  (TAS) innate immune response in mucosa  (IEA) negative regulation of acute inflammatory response  (IEA) negative regulation of apoptotic process  (ISS) negative regulation of chronic inflammatory response  (IEA) negative regulation of macrophage activation  (IEA) negative regulation of nitric oxide biosynthetic process  (IEA) negative regulation of osteoclast differentiation  (ISS) negative regulation of T-helper 17 cell differentiation  (IEA) negative regulation of transcription, DNA-dependent  (IDA) positive regulation of activated T cell proliferation  (IEA) positive regulation of B cell proliferation  (ISS) positive regulation of chemokine biosynthetic process  (IEA) positive regulation of interleukin-10 production  (IEA) positive regulation of interleukin-13 production  (IDA) positive regulation of isotype switching to IgE isotypes  (ISS) positive regulation of isotype switching to IgG isotypes  (ISS) positive regulation of MHC class II biosynthetic process  (ISS) positive regulation of sequence-specific DNA binding transcription factor activity  (IEA) positive regulation of T cell differentiation  (IDA) positive regulation of T cell proliferation  (ISS) positive regulation of transcription from RNA polymerase II promoter  (ISS) positive regulation of transcription, DNA-dependent  (IDA) positive regulation of tyrosine phosphorylation of Stat5 protein  (IEA) regulation of immune response  (ISS) regulation of isotype switching  (TAS) regulation of phosphorylation  (ISS) regulation of proton transport  (IEA) response to cytokine stimulus  (IEA) response to drug  (IEA) response to ethanol  (IEA) response to nutrient  (IEA) response to organic cyclic compound  (IEA) T-helper 1 cell lineage commitment  (IEA) T-helper 2 cell cytokine production  (IDA) T-helper 2 cell differentiation  (IEA) type 2 immune response  (TAS) Cellular Component external side of plasma membrane  (IEA) extracellular space  (TAS) Molecular Function cytokine activity  (IEA) growth factor activity  (NAS) interleukin-4 receptor binding  (TAS) protein binding  (IPI) Molecular Pathway Annotations allograft rejection pathway  (IEA) asthma disease pathway  (IEA) autoimmune thyroid disease pathway  (IEA) interleukin-12 signaling pathway  (EXP) interleukin-4 signaling pathway  (EXP) Jak-Stat signaling pathway  (IEA) Leishmania infection pathway  (IEA) measles infection pathway  (IEA) Notch signaling pathway  (EXP) T cell receptor signaling pathway  (IEA) External Database Links KEGG Pathway Allograft rejection Asthma Autoimmune thyroid disease Cytokine-cytokine receptor interaction Fc epsilon RI signaling pathway Hematopoietic cell lineage Intestinal immune network for IgA production Jak-STAT signaling pathway Leishmaniasis Measles PI3K-Akt signaling pathway T cell receptor signaling pathway Pathway Interaction Database AP-1 transcription factor network (PID:200137) Calcineurin-regulated NFAT-dependent transcription in lymphocytes (PID:200050) Calcium signaling in the CD4+ TCR pathway (PID:200185) CD40/CD40L signaling (PID:200037) Glucocorticoid receptor regulatory network (PID:200091) IL12-mediated signaling events (PID:200045) IL2 signaling events mediated by STAT5 (PID:200184) IL4-mediated signaling events (PID:200022) Notch signaling pathway (PID:200015) Phenotype Annotations abnormal motor capabilities/coordination/movement  (IAGP) References - curated 1. 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Lee SI, etal., J Neurosci Res. 2010 Aug 15;88(11):2409-19. 18. Li B, etal., Am J Transplant. 2008 Aug;8(8):1614-21. Epub 2008 Jun 28. 19. Li CC, etal., Zhonghua Er Ke Za Zhi. 2007 Oct;45(10):727-31. 20. Li YX, etal., Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2008 Jun;43(6):447-50. 21. Meng L, etal., PLoS One. 2011 Feb 25;6(2):e17252. 22. Michel S, etal., PLoS One. 2010 Nov 12;5(11):e13894. 23. Mitaka K, etal., Int Arch Allergy Immunol. 2011;154(3):264-74. Epub 2010 Sep 21. 24. Mo JH, etal., Allergy. 2011 Feb;66(2):279-86. doi: 10.1111/j.1398-9995.2010.02476.x. Epub 2010 Sep 7. 25. Nagarkar DR, etal., J Immunol. 2010 Aug 15;185(4):2525-35. Epub 2010 Jul 19. 26. Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology 27. Pipeline to import Pathway Interaction Database annotations from NCI into RGD 28. RGD automated import pipeline for gene-chemical interactions 29. Shahram F, etal., Clin Exp Rheumatol. 2011 May 31. 30. Shimamura T, etal., Cancer Res. 2007 Oct 15;67(20):9903-12. 31. Smaldone MC, etal., Urology. 2009 Feb;73(2):421-6. Epub 2008 Oct 9. 32. Swain SD, etal., Infect Immun. 2011 Feb 22. 33. Tam FW, etal., Kidney Int. 1997 Nov;52(5):1224-31. 34. Tripathi SS, etal., Arch Toxicol. 2010 Dec;84(12):947-55. Epub 2010 May 20. 35. Vandenbroeck K, etal., J Neuroimmunol 1997 Jun;76(1-2):189-92. 36. Xiao C, etal., Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2010 Oct;24(20):924-7. 37. Xu YH, etal., BMC Genomics. 2011 Jan 11;12:20. 38. Yamaji-Kegan K, etal., J Immunol. 2010 Nov 1;185(9):5539-48. Epub 2010 Oct 1. 39. Yorimitsu M, etal., Osteoarthritis Cartilage. 2008 Jul;16(7):764-71. Epub 2008 Jan 7. 40. Zhang D, etal., Arch Bronconeumol. 2010 Sep;46(9):459-65. Epub 2010 Jun 22. 41. Zhao S, etal., Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2008 Aug;22(16):751-5. 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15122773   15123681   15128803   15163899   15166131   15170937   15177147   15178889   15187156   15191519   15210741   15213252   15215692   15241348   15274656   15292002   15297269   15298559   15322832   15361128   15367434   15373917   15474066   15489334   15501397   15527169   15528258   15563083   15570643   15591113   15592292   15596681   15627726   15644127   15660235   15660293   15661875   15676220   15678501   1567880   1567881   15679809   15687724   1569578   15695802   15713213   15714203   15723707   15733644   15755291   15778356   15811521   15816837   15825027   15869882   15883744   15885323   15900570   15900573   15904474   15919378   15932621   15941525   15951665   15969687   15970635   16001979   16002690   16004996   16034134   16043936   16044136   16046318   16053729   16083175   16083600   16091861   1609277   16100774   16164695   16166103   16184405   16190985   16193177   16195814   16215326   16230423   16232344   16249002   16289646   16301860   16313303   16313681   16315031   16334248   16343431   16375755   16380445   16387595   16388492   16403098   16427155   16429138   16429733   16449530   16461126   16466711   16487180   16492782   16511411   16520888   16522370   16544245   16547227   16547693   16551465   16573560   16574063   16596275   16601843   16640778   16681592   16690518   16702372   16707627   16720107   16722389   16750991   16750993   16759385   16810739   16864907   16867043   16877367   16914241   16916659   16929824   16930576   16931887   16938461   16950634   16973957   16987060   17006724   17014622   17015714   17015735   17063753   17097641   17117487   17121586   17133536   17141086   17143971   17148075   17151125   17151939   17152005   17159260   17177148   17203290   17207024   17208210   17209513   17213232   17222831   17237413   17257312   17284225   17291854   17295710   17299718   17303794   17303923   17309781   17311314   17327605   17355643   17369174   17371990   17379175   17388919   17389011   17389870   17405833   17420820   17428692   17433443   17444864   17451413   17454884   17460561   17523428   17524861   17530998   17536219   17540990   17541280   17548690   17563406   17566759   17576577   17623648   17627763   17631734   17640324   17640674   17644317   17653830   17655693   17656331   17662651   17678726   17703412   17714919   17851828   17855802   17882904   17889143   17908769   17914408   17916404   17916900   17937745   17938902   17961771   17968425   18008330   18031948   18042256   18056382   18058260   18064451   18088017   18156980   18165865   18174230   18179754   18179773   18202702   18204280   18206261   18210751   18211631   18230112   18239807   18243101   18251702   18263811   18273035   18273643   18276105   18286287   18294957   18295676   18310157   18322173   18342537   18351434   18371377   18385759   18389618   18394346   18396027   18403443   18410779   18418228   18422436   18425216   18433468   18439079   18441098   18448485   18454680   18455629   18476609   18485518   18497474   18522869   18533937   18538381   18547691   18558283   18566561   18568448   18568476   18574615   18579517   18593330   18596736   18597704   18599603   18610831   18610832   18614592   18624944   18625055   18626468   18628242   18629290   18632425   18633131   18635180   18636124   18641314   18651887   18662263   18674658   18676680   18676870   18682601   18688110   18694328   18696265   18708672   18716132   18776133   18781131   18818748   18834248   18924208   18927306   18931892   18936436   18941246   18955794   18971287   18971305   18974110   18974840   19008611   19013323   19019335   19028820   19050632   19058298   19058839   19066394   19074885   19116009   19117745   19122650   19126646   19129082   19131452   19131662   19141349   19164348   19168731   19169254   19170196   19185507   19190772   19193442   19200845   19222422   19247692   19249119   19251840   19254294   19258923   19261373   19262574   19263529   19264973   19275586   19279357   1932028   19332120   19332998   19336370   19346497   19347053   19351467   19370405   19372547   19375306   19382262   19385959   19408823   19409508   19419769   19421745   19426601   19437232   1946344   19470040   19479237   19495883   19497039   19505916   19508433   19515749   19521787   19527514   19536153   19541591   19544559   19544973   19552791   19555572   19559392   19566553   19573080   19575932   19578876   19586918   19586939   19594368   19621989   19625176   19657367   19682920   19683555   19692168   19698128   19699526   19706316   19707465   19718656   19718824   19721012   19726720   19735490   19753334   19762488   19772762   19773279   19773451   19799628   19804407   19811408   19817957   19818512   19835477   19840389   19845895   19857574   19860911   19862939   19878651   19882211   19892918   19910025   19913121   19915002   1993171   19933216   19938203   19948975   19959237   20003246   20010912   20012528   20016407   20027321   20030788   20039421   20049266   20053586   20056178   20059579   20082482   20093796   20100010   20112007   20121760   20128416   20139223   20140262   20145925   20147633   20177758   20184663   20192866   20213229   20217044   20219689   20222161   20237496   20299965   20304823   20305143   20332709   20349326   20349753   20364398   20367137   20394509   20395963   20403914   20406299   20413987   20416077   20418110   20424473   20442634   20444155   20452482   20453000   20459687   20485362   20503287   20506498   20517665   20525402   20530519   20533927   20536507   20565368   20568250   20580039   20603037   20603050   20618516   20620947   20628086   20644561   20673868   20703737   20711808   20713631   20716621   20719954   20723894   20726231   20736038   20808855   20811626   20814620   20839488   20852371   20859068   20880001   20921925   20942272   20970781   20980261   21048327   21054877   21061265   21067483   21071541   21085635   21086908   21106245   21106524   21111725   21127885   21191414   21195738   21198753   21211660   21268015   21270410   21276216   21323696   21354455   21460743   21471214   21478113   21501388   21611195   21636115   21644211   21645924   21646796   21658970   21690322   21713407   21729106   21749213   21755390   21771210   21788379   21799768   21819409   21846818   21857939   21890374   21900165   21913997   21966389   21989417   22045834   22053598   22087298   22092872   22104567   22142023   22143036   22156341   22157213   22170601   22174091   22214155   22226971   22227092   22249152   22365405   22387551   22406175   22484241   22484276   22512783   22521249   22528336   22538865   22574929   22583827   22594992   22615205   22652416   22675249   22705603   22805022   22805115   22824342   22875803   22884982   22921153   22942430   22986179   22992805   23087426   23107766   23110190   23222300   23234779   2535858   3016727   3257560   7523014   7589092   7664036   7695626   7806280   7963560   8151703   8266078   8516290   8602263   8603435   8609418   8764000   9113989   9130521   9130652   9334723   9799097   9856950 RGD Disease Portals IL4 has been annotated in the following RGD Disease Portals. Biological Process Cancer Diseases Cancer Pathways Cardiovascular Diseases Cardiovascular Pathways Diabetes Diseases Diabetes Pathways Biological Process Immune and Inflammatory Diseases Immune and Inflammatory Pathways Neurological Diseases Neurological Pathways Biological Process Obesity Diseases Obesity Pathways Biological Process Respiratory Diseases Respiratory Pathways Genomics Comparative Map Data IL4   (Homo sapiens) Map Chr Position Strand Source Human Alternate Assembly CHM1_1 5 132,286,522 - 132,295,219 + NCBI Human Genome Assembly HuRef 5 127,201,979 - 127,210,672 + NCBI Human Genome Assembly GRCh37 5 132,009,678 - 132,018,370 + NCBI Human Genome Assembly Build 36 5 132,037,272 - 132,046,267 + NCBI Human Cytogenetic Map 5 q31.1   NCBI Human Genome Assembly 5 132,037,271 - 132,046,267   NCBI Il4   (Mus musculus) Map Chr Position Strand Source Mouse Genome Assembly GRCm38 11 53,612,460 - 53,618,665 - NCBI Mouse cM Map 11 31.97   NCBI Mouse Celera Assembly 11 58,191,990 - 58,198,195 - NCBI Mouse Genome Assembly Build 37 11 53,425,962 - 53,432,167 - NCBI Mouse Genome Assembly Build 36.1 11 53,425,970 - 53,432,167 - NCBI Mouse Cytogenetic Map 11 B1.3   NCBI Il4   (Rattus norvegicus) Map Chr Position Strand Source Rat Cytogenetic Map 10 q22   NCBI RGSC Genome Assembly v5.0 10 38,745,706 - 38,751,258 - NCBI RGSC Genome Assembly v3.4 10 39,074,582 - 39,080,134 - NCBI Rat Celera Assembly 10 37,115,496 - 37,120,965 - NCBI Genome Assembly 3.1 10 39,083,152 - 39,088,705 - NCBI Position Markers GDB:180247   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,203,801 - 127,203,984   UniSTS Human Genome Assembly GRCh37 5 132,011,499 - 132,011,682   UniSTS Human Celera Assembly 5 128,141,629 - 128,141,838   RGD Human Genome Assembly Build 36 5 132,039,398 - 132,039,581   RGD Human Cytogenetic Map 5 q31.1   UniSTS GDB:180248   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,208,555 - 127,208,808   UniSTS Human Genome Assembly GRCh37 5 132,016,253 - 132,016,506   UniSTS Human Celera Assembly 5 128,146,409 - 128,146,662   RGD Human Genome Assembly Build 36 5 132,044,152 - 132,044,405   RGD Human Cytogenetic Map 5 q31.1   UniSTS PMC324417P1   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,202,123 - 127,202,477   UniSTS Human Genome Assembly GRCh37 5 132,009,822 - 132,010,176   UniSTS Human Celera Assembly 5 128,139,951 - 128,140,305   RGD Human Genome Assembly Build 36 5 132,037,721 - 132,038,075   RGD Human Cytogenetic Map 5 q31.1   UniSTS PMC356970P2   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,202,015 - 127,202,482   UniSTS Human Genome Assembly GRCh37 5 132,009,714 - 132,010,181   UniSTS Human Celera Assembly 5 128,139,843 - 128,140,310   RGD Human Genome Assembly Build 36 5 132,037,613 - 132,038,080   RGD Human Cytogenetic Map 5 q31.1   UniSTS ECD00749   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,207,103 - 127,207,994   UniSTS Human Genome Assembly GRCh37 5 132,014,801 - 132,015,692   UniSTS Human Celera Assembly 5 128,144,957 - 128,145,848   RGD Human Genome Assembly Build 36 5 132,042,700 - 132,043,591   RGD Human Cytogenetic Map 5 q31.1   UniSTS ECD01760   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,205,201 - 127,206,055   UniSTS Human Genome Assembly GRCh37 5 132,012,899 - 132,013,753   UniSTS Human Celera Assembly 5 128,143,055 - 128,143,909   RGD Human Genome Assembly Build 36 5 132,040,798 - 132,041,652   RGD Human Cytogenetic Map 5 q31.1   UniSTS ECD02519   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,204,344 - 127,205,171   UniSTS Human Genome Assembly GRCh37 5 132,012,042 - 132,012,869   UniSTS Human Celera Assembly 5 128,142,198 - 128,143,025   RGD Human Genome Assembly Build 36 5 132,039,941 - 132,040,768   RGD Human Cytogenetic Map 5 q31.1   UniSTS ECD07045   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,202,061 - 127,202,753   UniSTS Human Genome Assembly GRCh37 5 132,009,760 - 132,010,452   UniSTS Human Celera Assembly 5 128,139,889 - 128,140,581   RGD Human Genome Assembly Build 36 5 132,037,659 - 132,038,351   RGD Human Cytogenetic Map 5 q31.1   UniSTS ECD08604   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,201,341 - 127,201,991   UniSTS Human Genome Assembly GRCh37 5 132,009,040 - 132,009,690   UniSTS Human Celera Assembly 5 128,139,169 - 128,139,819   RGD Human Genome Assembly Build 36 5 132,036,939 - 132,037,589   RGD Human Cytogenetic Map 5 q31.1   UniSTS ECD08735   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,202,889 - 127,203,536   UniSTS Human Genome Assembly GRCh37 5 132,010,588 - 132,011,235   UniSTS Human Celera Assembly 5 128,140,717 - 128,141,364   RGD Human Genome Assembly Build 36 5 132,038,487 - 132,039,134   RGD Human Cytogenetic Map 5 q31.1   UniSTS ECD12380   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,210,006 - 127,210,551   UniSTS Human Genome Assembly GRCh37 5 132,017,704 - 132,018,249   UniSTS Human Celera Assembly 5 128,147,860 - 128,148,405   RGD Human Genome Assembly Build 36 5 132,045,603 - 132,046,148   RGD Human Cytogenetic Map 5 q31.1   UniSTS ECD19759   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,200,699 - 127,201,009   UniSTS Human Genome Assembly GRCh37 5 132,008,397 - 132,008,707   UniSTS Human Celera Assembly 5 128,138,527 - 128,138,837   RGD Human Genome Assembly Build 36 5 132,036,296 - 132,036,606   RGD Human Cytogenetic Map 5 q31.1   UniSTS ECD20165   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,206,714 - 127,207,008   UniSTS Human Genome Assembly GRCh37 5 132,014,412 - 132,014,706   UniSTS Human Celera Assembly 5 128,144,568 - 128,144,862   RGD Human Genome Assembly Build 36 5 132,042,311 - 132,042,605   RGD Human Cytogenetic Map 5 q31.1   UniSTS ECD22217   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,210,777 - 127,211,002   UniSTS Human Genome Assembly GRCh37 5 132,018,475 - 132,018,700   UniSTS Human Celera Assembly 5 128,148,631 - 128,148,856   RGD Human Genome Assembly Build 36 5 132,046,374 - 132,046,599   RGD Human Cytogenetic Map 5 q31.1   UniSTS REN71218   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,200,572 - 127,200,821   UniSTS Human Genome Assembly GRCh37 5 132,008,270 - 132,008,519   UniSTS Human Celera Assembly 5 128,138,400 - 128,138,649   RGD Human Genome Assembly Build 36 5 132,036,169 - 132,036,418   RGD Human Cytogenetic Map 5 q31.1   UniSTS REN71219   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,200,750 - 127,200,993   UniSTS Human Genome Assembly GRCh37 5 132,008,448 - 132,008,691   UniSTS Human Celera Assembly 5 128,138,578 - 128,138,821   RGD Human Genome Assembly Build 36 5 132,036,347 - 132,036,590   RGD Human Cytogenetic Map 5 q31.1   UniSTS REN71220   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,200,861 - 127,201,109   UniSTS Human Genome Assembly GRCh37 5 132,008,559 - 132,008,807   UniSTS Human Celera Assembly 5 128,138,689 - 128,138,937   RGD Human Genome Assembly Build 36 5 132,036,458 - 132,036,706   RGD Human Cytogenetic Map 5 q31.1   UniSTS REN71221   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,201,098 - 127,201,346   UniSTS Human Genome Assembly GRCh37 5 132,008,796 - 132,009,045   UniSTS Human Celera Assembly 5 128,138,926 - 128,139,174   RGD Human Genome Assembly Build 36 5 132,036,695 - 132,036,944   RGD Human Cytogenetic Map 5 q31.1   UniSTS REN71222   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,201,345 - 127,201,582   UniSTS Human Genome Assembly GRCh37 5 132,009,044 - 132,009,281   UniSTS Human Celera Assembly 5 128,139,173 - 128,139,410   RGD Human Genome Assembly Build 36 5 132,036,943 - 132,037,180   RGD Human Cytogenetic Map 5 q31.1   UniSTS REN71223   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,201,558 - 127,201,818   UniSTS Human Genome Assembly GRCh37 5 132,009,257 - 132,009,517   UniSTS Human Celera Assembly 5 128,139,386 - 128,139,646   RGD Human Genome Assembly Build 36 5 132,037,156 - 132,037,416   RGD Human Cytogenetic Map 5 q31.1   UniSTS REN71224   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,201,800 - 127,202,047   UniSTS Human Genome Assembly GRCh37 5 132,009,499 - 132,009,746   UniSTS Human Celera Assembly 5 128,139,628 - 128,139,875   RGD Human Genome Assembly Build 36 5 132,037,398 - 132,037,645   RGD Human Cytogenetic Map 5 q31.1   UniSTS REN71225   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,202,039 - 127,202,284   UniSTS Human Genome Assembly GRCh37 5 132,009,738 - 132,009,983   UniSTS Human Celera Assembly 5 128,139,867 - 128,140,112   RGD Human Genome Assembly Build 36 5 132,037,637 - 132,037,882   RGD Human Cytogenetic Map 5 q31.1   UniSTS REN71226   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,202,259 - 127,202,490   UniSTS Human Genome Assembly GRCh37 5 132,009,958 - 132,010,189   UniSTS Human Celera Assembly 5 128,140,087 - 128,140,318   RGD Human Genome Assembly Build 36 5 132,037,857 - 132,038,088   RGD Human Cytogenetic Map 5 q31.1   UniSTS REN71227   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,202,482 - 127,202,726   UniSTS Human Genome Assembly GRCh37 5 132,010,181 - 132,010,425   UniSTS Human Celera Assembly 5 128,140,310 - 128,140,554   RGD Human Genome Assembly Build 36 5 132,038,080 - 132,038,324   RGD Human Cytogenetic Map 5 q31.1   UniSTS REN71228   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,202,724 - 127,202,958   UniSTS Human Genome Assembly GRCh37 5 132,010,423 - 132,010,657   UniSTS Human Celera Assembly 5 128,140,552 - 128,140,786   RGD Human Genome Assembly Build 36 5 132,038,322 - 132,038,556   RGD Human Cytogenetic Map 5 q31.1   UniSTS REN71229   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,202,935 - 127,203,195   UniSTS Human Genome Assembly GRCh37 5 132,010,634 - 132,010,894   UniSTS Human Celera Assembly 5 128,140,763 - 128,141,023   RGD Human Genome Assembly Build 36 5 132,038,533 - 132,038,793   RGD Human Cytogenetic Map 5 q31.1   UniSTS REN71230   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,203,160 - 127,203,429   UniSTS Human Genome Assembly GRCh37 5 132,010,859 - 132,011,128   UniSTS Human Celera Assembly 5 128,140,988 - 128,141,257   RGD Human Genome Assembly Build 36 5 132,038,758 - 132,039,027   RGD Human Cytogenetic Map 5 q31.1   UniSTS REN71231   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,203,358 - 127,203,628   UniSTS Human Genome Assembly GRCh37 5 132,011,057 - 132,011,326   UniSTS Human Celera Assembly 5 128,141,186 - 128,141,456   RGD Human Genome Assembly Build 36 5 132,038,956 - 132,039,225   RGD Human Cytogenetic Map 5 q31.1   UniSTS REN71232   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,203,598 - 127,203,850   UniSTS Human Genome Assembly GRCh37 5 132,011,296 - 132,011,548   UniSTS Human Celera Assembly 5 128,141,426 - 128,141,678   RGD Human Genome Assembly Build 36 5 132,039,195 - 132,039,447   RGD Human Cytogenetic Map 5 q31.1   UniSTS REN71233   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,203,829 - 127,204,064   UniSTS Human Genome Assembly GRCh37 5 132,011,527 - 132,011,762   UniSTS Human Celera Assembly 5 128,141,657 - 128,141,918   RGD Human Genome Assembly Build 36 5 132,039,426 - 132,039,661   RGD Human Cytogenetic Map 5 q31.1   UniSTS REN71234   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,204,041 - 127,204,299   UniSTS Human Genome Assembly GRCh37 5 132,011,739 - 132,011,997   UniSTS Human Celera Assembly 5 128,141,895 - 128,142,153   RGD Human Genome Assembly Build 36 5 132,039,638 - 132,039,896   RGD Human Cytogenetic Map 5 q31.1   UniSTS REN71235   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,204,279 - 127,204,524   UniSTS Human Genome Assembly GRCh37 5 132,011,977 - 132,012,222   UniSTS Human Celera Assembly 5 128,142,133 - 128,142,378   RGD Human Genome Assembly Build 36 5 132,039,876 - 132,040,121   RGD Human Cytogenetic Map 5 q31.1   UniSTS REN71236   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,204,501 - 127,204,751   UniSTS Human Genome Assembly GRCh37 5 132,012,199 - 132,012,449   UniSTS Human Celera Assembly 5 128,142,355 - 128,142,605   RGD Human Genome Assembly Build 36 5 132,040,098 - 132,040,348   RGD Human Cytogenetic Map 5 q31.1   UniSTS REN71237   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,204,728 - 127,204,957   UniSTS Human Genome Assembly GRCh37 5 132,012,426 - 132,012,655   UniSTS Human Celera Assembly 5 128,142,582 - 128,142,811   RGD Human Genome Assembly Build 36 5 132,040,325 - 132,040,554   RGD Human Cytogenetic Map 5 q31.1   UniSTS REN71238   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,204,933 - 127,205,180   UniSTS Human Genome Assembly GRCh37 5 132,012,631 - 132,012,878   UniSTS Human Celera Assembly 5 128,142,787 - 128,143,034   RGD Human Genome Assembly Build 36 5 132,040,530 - 132,040,777   RGD Human Cytogenetic Map 5 q31.1   UniSTS REN71239   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,205,150 - 127,205,398   UniSTS Human Genome Assembly GRCh37 5 132,012,848 - 132,013,096   UniSTS Human Celera Assembly 5 128,143,004 - 128,143,252   RGD Human Genome Assembly Build 36 5 132,040,747 - 132,040,995   RGD Human Cytogenetic Map 5 q31.1   UniSTS REN71240   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,205,378 - 127,205,603   UniSTS Human Genome Assembly GRCh37 5 132,013,076 - 132,013,301   UniSTS Human Celera Assembly 5 128,143,232 - 128,143,457   RGD Human Genome Assembly Build 36 5 132,040,975 - 132,041,200   RGD Human Cytogenetic Map 5 q31.1   UniSTS REN71241   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,205,571 - 127,205,818   UniSTS Human Genome Assembly GRCh37 5 132,013,269 - 132,013,516   UniSTS Human Celera Assembly 5 128,143,425 - 128,143,672   RGD Human Genome Assembly Build 36 5 132,041,168 - 132,041,415   RGD Human Cytogenetic Map 5 q31.1   UniSTS REN71242   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,205,798 - 127,206,045   UniSTS Human Genome Assembly GRCh37 5 132,013,496 - 132,013,743   UniSTS Human Celera Assembly 5 128,143,652 - 128,143,899   RGD Human Genome Assembly Build 36 5 132,041,395 - 132,041,642   RGD Human Cytogenetic Map 5 q31.1   UniSTS REN71243   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,206,031 - 127,206,274   UniSTS Human Genome Assembly GRCh37 5 132,013,729 - 132,013,972   UniSTS Human Celera Assembly 5 128,143,885 - 128,144,128   RGD Human Genome Assembly Build 36 5 132,041,628 - 132,041,871   RGD Human Cytogenetic Map 5 q31.1   UniSTS REN71244   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,206,204 - 127,206,449   UniSTS Human Genome Assembly GRCh37 5 132,013,902 - 132,014,147   UniSTS Human Celera Assembly 5 128,144,058 - 128,144,303   RGD Human Genome Assembly Build 36 5 132,041,801 - 132,042,046   RGD Human Cytogenetic Map 5 q31.1   UniSTS REN71245   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,206,407 - 127,206,655   UniSTS Human Genome Assembly GRCh37 5 132,014,105 - 132,014,353   UniSTS Human Celera Assembly 5 128,144,261 - 128,144,509   RGD Human Genome Assembly Build 36 5 132,042,004 - 132,042,252   RGD Human Cytogenetic Map 5 q31.1   UniSTS REN71246   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,206,629 - 127,206,895   UniSTS Human Genome Assembly GRCh37 5 132,014,327 - 132,014,593   UniSTS Human Celera Assembly 5 128,144,483 - 128,144,749   RGD Human Genome Assembly Build 36 5 132,042,226 - 132,042,492   RGD Human Cytogenetic Map 5 q31.1   UniSTS REN71247   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,206,882 - 127,207,134   UniSTS Human Genome Assembly GRCh37 5 132,014,580 - 132,014,832   UniSTS Human Celera Assembly 5 128,144,736 - 128,144,988   RGD Human Genome Assembly Build 36 5 132,042,479 - 132,042,731   RGD Human Cytogenetic Map 5 q31.1   UniSTS REN71248   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,207,107 - 127,207,359   UniSTS Human Genome Assembly GRCh37 5 132,014,805 - 132,015,057   UniSTS Human Celera Assembly 5 128,144,961 - 128,145,213   RGD Human Genome Assembly Build 36 5 132,042,704 - 132,042,956   RGD Human Cytogenetic Map 5 q31.1   UniSTS REN71249   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,207,340 - 127,207,578   UniSTS Human Genome Assembly GRCh37 5 132,015,038 - 132,015,276   UniSTS Human Celera Assembly 5 128,145,194 - 128,145,432   RGD Human Genome Assembly Build 36 5 132,042,937 - 132,043,175   RGD Human Cytogenetic Map 5 q31.1   UniSTS REN71250   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,207,558 - 127,207,782   UniSTS Human Genome Assembly GRCh37 5 132,015,256 - 132,015,480   UniSTS Human Celera Assembly 5 128,145,412 - 128,145,636   RGD Human Genome Assembly Build 36 5 132,043,155 - 132,043,379   RGD Human Cytogenetic Map 5 q31.1   UniSTS REN71251   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,207,756 - 127,208,003   UniSTS Human Genome Assembly GRCh37 5 132,015,454 - 132,015,701   UniSTS Human Celera Assembly 5 128,145,610 - 128,145,857   RGD Human Genome Assembly Build 36 5 132,043,353 - 132,043,600   RGD Human Cytogenetic Map 5 q31.1   UniSTS REN71252   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,207,934 - 127,208,161   UniSTS Human Genome Assembly GRCh37 5 132,015,632 - 132,015,859   UniSTS Human Celera Assembly 5 128,145,788 - 128,146,015   RGD Human Genome Assembly Build 36 5 132,043,531 - 132,043,758   RGD Human Cytogenetic Map 5 q31.1   UniSTS REN71253   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,208,152 - 127,208,412   UniSTS Human Genome Assembly GRCh37 5 132,015,850 - 132,016,110   UniSTS Human Celera Assembly 5 128,146,006 - 128,146,266   RGD Human Genome Assembly Build 36 5 132,043,749 - 132,044,009   RGD Human Cytogenetic Map 5 q31.1   UniSTS REN71254   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,208,359 - 127,208,592   UniSTS Human Genome Assembly GRCh37 5 132,016,057 - 132,016,290   UniSTS Human Celera Assembly 5 128,146,213 - 128,146,446   RGD Human Genome Assembly Build 36 5 132,043,956 - 132,044,189   RGD Human Cytogenetic Map 5 q31.1   UniSTS REN71255   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,208,567 - 127,208,817   UniSTS Human Genome Assembly GRCh37 5 132,016,265 - 132,016,515   UniSTS Human Celera Assembly 5 128,146,421 - 128,146,671   RGD Human Genome Assembly Build 36 5 132,044,164 - 132,044,414   RGD Human Cytogenetic Map 5 q31.1   UniSTS REN71256   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,208,797 - 127,209,060   UniSTS Human Genome Assembly GRCh37 5 132,016,495 - 132,016,758   UniSTS Human Celera Assembly 5 128,146,651 - 128,146,914   RGD Human Genome Assembly Build 36 5 132,044,394 - 132,044,657   RGD Human Cytogenetic Map 5 q31.1   UniSTS REN71257   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,209,013 - 127,209,266   UniSTS Human Genome Assembly GRCh37 5 132,016,711 - 132,016,964   UniSTS Human Celera Assembly 5 128,146,867 - 128,147,120   RGD Human Genome Assembly Build 36 5 132,044,610 - 132,044,863   RGD Human Cytogenetic Map 5 q31.1   UniSTS REN71258   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,209,262 - 127,209,512   UniSTS Human Genome Assembly GRCh37 5 132,016,960 - 132,017,210   UniSTS Human Celera Assembly 5 128,147,116 - 128,147,366   RGD Human Genome Assembly Build 36 5 132,044,859 - 132,045,109   RGD Human Cytogenetic Map 5 q31.1   UniSTS REN71259   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,209,489 - 127,209,749   UniSTS Human Genome Assembly GRCh37 5 132,017,187 - 132,017,447   UniSTS Human Celera Assembly 5 128,147,343 - 128,147,603   RGD Human Genome Assembly Build 36 5 132,045,086 - 132,045,346   RGD Human Cytogenetic Map 5 q31.1   UniSTS REN71260   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,209,745 - 127,209,976   UniSTS Human Genome Assembly GRCh37 5 132,017,443 - 132,017,674   UniSTS Human Celera Assembly 5 128,147,599 - 128,147,830   RGD Human Genome Assembly Build 36 5 132,045,342 - 132,045,573   RGD Human Cytogenetic Map 5 q31.1   UniSTS REN71261   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,209,967 - 127,210,191   UniSTS Human Genome Assembly GRCh37 5 132,017,665 - 132,017,889   UniSTS Human Celera Assembly 5 128,147,821 - 128,148,045   RGD Human Genome Assembly Build 36 5 132,045,564 - 132,045,788   RGD Human Cytogenetic Map 5 q31.1   UniSTS REN71262   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,210,150 - 127,210,401   UniSTS Human Genome Assembly GRCh37 5 132,017,848 - 132,018,099   UniSTS Human Celera Assembly 5 128,148,004 - 128,148,255   RGD Human Genome Assembly Build 36 5 132,045,747 - 132,045,998   RGD Human Cytogenetic Map 5 q31.1   UniSTS REN71263   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,210,338 - 127,210,587   UniSTS Human Genome Assembly GRCh37 5 132,018,036 - 132,018,285   UniSTS Human Celera Assembly 5 128,148,192 - 128,148,441   RGD Human Genome Assembly Build 36 5 132,045,935 - 132,046,184   RGD Human Cytogenetic Map 5 q31.1   UniSTS REN71264   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,210,555 - 127,210,804   UniSTS Human Genome Assembly GRCh37 5 132,018,253 - 132,018,502   UniSTS Human Celera Assembly 5 128,148,409 - 128,148,658   RGD Human Genome Assembly Build 36 5 132,046,152 - 132,046,401   RGD Human Cytogenetic Map 5 q31.1   UniSTS REN71265   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,210,781 - 127,211,041   UniSTS Human Genome Assembly GRCh37 5 132,018,479 - 132,018,739   UniSTS Human Celera Assembly 5 128,148,635 - 128,148,895   RGD Human Genome Assembly Build 36 5 132,046,378 - 132,046,638   RGD Human Cytogenetic Map 5 q31.1   UniSTS stSG601440   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,200,293 - 127,201,407   UniSTS Human Genome Assembly GRCh37 5 132,007,991 - 132,009,106   UniSTS Human Celera Assembly 5 128,138,121 - 128,139,235   RGD Human Genome Assembly Build 36 5 132,035,890 - 132,037,005   RGD stSG601441   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,201,388 - 127,202,456   UniSTS Human Genome Assembly GRCh37 5 132,009,087 - 132,010,155   UniSTS Human Celera Assembly 5 128,139,216 - 128,140,284   RGD Human Genome Assembly Build 36 5 132,036,986 - 132,038,054   RGD stSG601442   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,202,435 - 127,203,522   UniSTS Human Genome Assembly GRCh37 5 132,010,134 - 132,011,221   UniSTS Human Celera Assembly 5 128,140,263 - 128,141,350   RGD Human Genome Assembly Build 36 5 132,038,033 - 132,039,120   RGD stSG601443   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,203,517 - 127,204,979   UniSTS Human Genome Assembly GRCh37 5 132,011,216 - 132,012,677   UniSTS Human Celera Assembly 5 128,141,345 - 128,142,833   RGD Human Genome Assembly Build 36 5 132,039,115 - 132,040,576   RGD stSG601444   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,204,962 - 127,206,222   UniSTS Human Genome Assembly GRCh37 5 132,012,660 - 132,013,920   UniSTS Human Celera Assembly 5 128,142,816 - 128,144,076   RGD Human Genome Assembly Build 36 5 132,040,559 - 132,041,819   RGD stSG601445   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,206,203 - 127,207,668   UniSTS Human Genome Assembly GRCh37 5 132,013,901 - 132,015,366   UniSTS Human Celera Assembly 5 128,144,057 - 128,145,522   RGD Human Genome Assembly Build 36 5 132,041,800 - 132,043,265   RGD stSG601446   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,206,996 - 127,207,995   UniSTS Human Genome Assembly GRCh37 5 132,014,694 - 132,015,693   UniSTS Human Celera Assembly 5 128,144,850 - 128,145,849   RGD Human Genome Assembly Build 36 5 132,042,593 - 132,043,592   RGD stSG601447   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,209,779 - 127,210,834   UniSTS Human Genome Assembly GRCh37 5 132,017,477 - 132,018,532   UniSTS Human Celera Assembly 5 128,147,633 - 128,148,688   RGD Human Genome Assembly Build 36 5 132,045,376 - 132,046,431   RGD IL4   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,201,919 - 127,202,068   UniSTS Human Genome Assembly GRCh37 5 132,009,618 - 132,009,767   UniSTS Human Celera Assembly 5 128,139,747 - 128,139,896   RGD Human Genome Assembly Build 36 5 132,037,517 - 132,037,666   RGD GDB:456299   Map Chr Position Strand Source Human Cytogenetic Map 5 q31.1   UniSTS GDB:207332   Map Chr Position Strand Source Human Cytogenetic Map 5 q31.1   UniSTS QTLs in Region (Human Genome Assembly GRCh37) The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer RGD ID Symbol Name LOD P Value Trait Sub Trait Chr Start Stop Species 1298472 BP21_H Blood pressure QTL 21 (human) .0785 Blood pressure hypertension susceptibility 5 131143833 157143833 Human 1331659 AASTH4_H Allergic/atopic asthma related QTL 4 (human) 2.73 .0002 Reversible airflow obstruction post-bronchodilator FEV1 5 118041132 144041132 Human 1357301 AASTH17_H Allergic/atopic asthma related QTL 17 (human) 2.18 .0007 Reversible airflow obstruction atopy score 5 128191539 152549542 Human 1357309 AASTH55_H Allergic/atopic asthma related QTL 5 (human) .0001 Atopy reversible airflow obstruction 5 122701420 148701420 Human 1357331 AASTH10_H Allergic/atopic asthma related QTL 10 (human) 1.23 Reversible airflow obstruction ETS positive 5 81673046 155668491 Human 1357329 AASTH46_H Allergic/atopic asthma related QTL 46 (human) .0079 Reversible airflow obstruction 5 131143833 157143833 Human 1357383 BW61_H Body weight QTL 61 (human) 2.4 .0004 Body weight BMI after exercise training 5 34952160 147315481 Human 1357317 AASTH19_H Allergic/atopic asthma related QTL 19 (human) .98 Reversible airflow obstruction post-bronchodilator FEV1 5 131143833 157143833 Human 1358844 MULTSCL15_H Multiple sclerosis susceptibility QTL 15 (human) Multiple sclerosis susceptibility 5 122301631 148301631 Human 1559217 SCL48_H Serum cholesterol level QTL 48 (human) 2.4 Lipid level HDL cholesterol 5 106101774 132101774 Human 1643519 BW263_H Body Weight QTL 263 (human) 1.5 .00394 Body weight body mass index 5 106101774 132101774 Human 2289311 BW380_H Body weight QTL 380 (human) 2.06 .00104 Body fat amount abdominal 5 127373052 153373052 Human 2289309 BW382_H Body weight QTL 382 (human) 1.87 .00169 Body fat amount abdominal 5 131143833 157143833 Human 2289319 BW381_H Body weight QTL 381 (human) 1.84 .00179 Body fat amount abdominal 5 127373052 153373052 Human 1643241 BW129_H Body Weight QTL 129 (human) .93 .019 Body weight body mass index 5 119101646 135301752 Human 2292894 MYI26_H Myocardial infarction susceptibility QTL 26 (human) Myocardial infarction susceptibility early-onset 5 106101774 132101774 Human 2292833 MYI25_H Myocardial infarction susceptibility QTL 25 (human) Myocardial infarction susceptibility early-onset 5 106101774 132101774 Human 2316337 GLUCO226_H Glucose level QTL 226 (human) .84 .02 Glucose level 5 122301631 148301631 Human 2316336 GLUCO233_H Glucose level QTL 233 (human) 2.41 Glucose level 5 122301631 148301631 Human Sequence Nucleotide Sequences Nucleotide RefSeqs NG_023252 (Get FASTA) Search GEO for Microarray Profiles   NM_000589 (Get FASTA) Search GEO for Microarray Profiles   NM_172348 (Get FASTA) Search GEO for Microarray Profiles GenBank Nucleotide AB102862 (Get FASTA) Search GEO for Microarray Profiles   ABBA01068803 (Get FASTA) Search GEO for Microarray Profiles   AC004039 (Get FASTA) Search GEO for Microarray Profiles   AF043336 (Get FASTA) Search GEO for Microarray Profiles   AF395008 (Get FASTA) Search GEO for Microarray Profiles   AF465829 (Get FASTA) Search GEO for Microarray Profiles   AM937235 (Get FASTA) Search GEO for Microarray Profiles   AMYH01015616 (Get FASTA) Search GEO for Microarray Profiles   BC066277 (Get FASTA) Search GEO for Microarray Profiles   BC066278 (Get FASTA) Search GEO for Microarray Profiles   BC067514 (Get FASTA) Search GEO for Microarray Profiles   BC067515 (Get FASTA) Search GEO for Microarray Profiles   BC070123 (Get FASTA) Search GEO for Microarray Profiles   CD640452 (Get FASTA) Search GEO for Microarray Profiles   CH471062 (Get FASTA) Search GEO for Microarray Profiles   CS255762 (Get FASTA) Search GEO for Microarray Profiles   EF173851 (Get FASTA) Search GEO for Microarray Profiles   FB507239 (Get FASTA) Search GEO for Microarray Profiles   FJ807883 (Get FASTA) Search GEO for Microarray Profiles   HC679221 (Get FASTA) Search GEO for Microarray Profiles   HH829894 (Get FASTA) Search GEO for Microarray Profiles   M13982 (Get FASTA) Search GEO for Microarray Profiles   M23442 (Get FASTA) Search GEO for Microarray Profiles   X06750 (Get FASTA) Search GEO for Microarray Profiles   X81851 (Get FASTA) Search GEO for Microarray Profiles Reference Sequences RefSeq Acc Id: NM_000589 RefSeq Status: REVIEWED Type: CODING Protein Acc Id: NP_000580 Peptide Label: isoform 1 precursor Position: Map Chr Position Strand Source Human Alternate Assembly CHM1_1 5 132,286,522 - 132,295,219 + NCBI Human Genome Assembly HuRef 5 127,201,979 - 127,210,672 + NCBI Human Genome Assembly GRCh37 5 132,009,678 - 132,018,370 + NCBI Human Genome Assembly Build 36 5 132,037,272 - 132,046,267 + NCBI Archive RefSeq Acc Id: NM_172348 RefSeq Status: REVIEWED Type: CODING Protein Acc Id: NP_758858 Peptide Label: isoform 2 precursor Position: Map Chr Position Strand Source Human Alternate Assembly CHM1_1 5 132,286,522 - 132,295,219 + NCBI Human Genome Assembly HuRef 5 127,201,979 - 127,210,672 + NCBI Human Genome Assembly GRCh37 5 132,009,678 - 132,018,370 + NCBI Human Genome Assembly Build 36 5 132,037,272 - 132,046,267 + NCBI Archive Protein Sequences Protein RefSeqs NP_000580 (Get FASTA)   NP_758858 (Get FASTA) GenBank Protein AAA59149 (Get FASTA)   AAA59150 (Get FASTA)   AAC03537 (Get FASTA)   AAH66277 (Get FASTA)   AAH67514 (Get FASTA)   AAH67515 (Get FASTA)   AAH70123 (Get FASTA)   AAK71324 (Get FASTA)   ABM53124 (Get FASTA)   ADD60204 (Get FASTA)   BAD89396 (Get FASTA)   CAA29925 (Get FASTA)   CAA57444 (Get FASTA)   CAJ75955 (Get FASTA)   CAP72493 (Get FASTA)   CAV32874 (Get FASTA)   CBL86566 (Get FASTA)   CBX32734 (Get FASTA)   EAW62322 (Get FASTA)   EAW62323 (Get FASTA)   P05112 (Get FASTA) Promoters RGD ID: 6850126 Promoter ID: EP26038 Type: single initiation site Name: HS_IL4 Description: Interleukin-4, B-cell stimulating factor-1, IL4 gene. SO ACC ID: SO:0000170 Source: EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/) Notes: homology_group=Homology group 151; Mammalian interleukin-4 Experiment Methods: Sequencing of a full-length cDNA; Nuclease protection with homologous sequence ladder; experiments; performed with closely related gene Regulation: helper T (repressed by or weakly expressed in) cells; (induced by or strongly expressed in) antigens Position: Map Chr Position Strand Source Human Genome Assembly Build 36 5 132,037,577 - 132,037,637   EPD RGD ID: 6803267 Promoter ID: HG_KWN:51063 Type: Non-CpG SO ACC ID: SO:0000170 Source: MPROMDB Tissues & Cell Lines: Lymphoblastoid Transcripts: NM_000589,   NM_172348,   OTTHUMT00000157346 Position: Map Chr Position Strand Source Human Genome Assembly Build 36 5 132,037,721 - 132,038,221 + MPROMDB Additional Information External Database Links Database Acc Id Source(s) COSMIC IL4 COSMIC Ensembl Genes ENSG00000113520 ENTREZGENE Ensembl Protein ENSP00000231449 ENTREZGENE Ensembl Transcript ENST00000231449 ENTREZGENE Entrez Gene 3565 ENTREZGENE Gene3D-CATH 4_helix_cytokine_core UniProtKB/Swiss-Prot Germonline ENSG00000113520 HGNC ID 6014 ENTREZGENE HomoloGene Group ID 491 ENTREZGENE HPRD ID 00989 ENTREZGENE InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot   4_helix_cytokine_core UniProtKB/Swiss-Prot   Interleukin-4 UniProtKB/Swiss-Prot   Interleukin-4/-13_CS UniProtKB/Swiss-Prot   Interleukin-4/13 UniProtKB/Swiss-Prot IPI IPI00007081 UniProtKB/Swiss-Prot   IPI00217945 UniProtKB/Swiss-Prot KEGG Report hsa:3565 ENTREZGENE, UniProtKB/Swiss-Prot OMIM 147780 OMIM PANTHER Interleukin_4 UniProtKB/Swiss-Prot Pfam IL4 UniProtKB/Swiss-Prot PharmGKB PA197 PharmGKB PIRSF Interleukin_4 UniProtKB/Swiss-Prot PRINTS INTERLEUKIN4 UniProtKB/Swiss-Prot PROSITE INTERLEUKIN_4_13 UniProtKB/Swiss-Prot SMART IL4_13 UniProtKB/Swiss-Prot Superfamily-SCOP 4_helix_cytokine UniProtKB/Swiss-Prot UniGene Hs.73917 ENTREZGENE UniProt D4HNR6_HUMAN UniProtKB/TrEMBL   IL4_HUMAN UniProtKB/Swiss-Prot   Q5FC01_HUMAN UniProtKB/TrEMBL Nomenclature History Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status 2011-08-16 IL4  interleukin 4  IL4  interleukin 4  Symbol and/or name change 39860 APPROVED

More on IL4 Entrez Gene Ensembl Gene Genome Browser: (hg18) (hg19) HGNC Report NCBI Map Viewer Vista Vista + UCSC RGD Object Information RGD ID: 736306 Created: 2004-02-06 Species: Homo sapiens Last Modified: 2013-04-30 Status: ACTIVE