PCNA (proliferating cell nuclear antigen)

Help | FTP Download | Citing RGD | Contact Us

Keyword

Gene: PCNA (proliferating cell nuclear antigen) Homo sapiens

Symbol:

PCNA

Name:

proliferating cell nuclear antigen

Description:

The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. [provided by RefSeq, Jul 2008]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

cyclin; DNA polymerase delta auxiliary protein; MGC8367; OTTHUMP00000030189; OTTHUMP00000030190; proliferating cell nuclear antigen

Orthologs:

Mus musculus : Pcna (proliferating cell nuclear antigen) MGI
Rattus norvegicus : Pcna (proliferating cell nuclear antigen)

Related Pseudogenes:

PCNAP1 PCNAP2 PCNAP3 PCNAP4

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	20	5,043,483 - 5,055,152	-	NCBI
Human Genome Assembly HuRef	20	5,049,534 - 5,061,197	-	NCBI
Human Genome Assembly GRCh37	20	5,095,599 - 5,107,268	-	NCBI
Human Genome Assembly Build 36	20	5,043,599 - 5,055,268	-	NCBI
Human Cytogenetic Map	20	pter-p12		NCBI
Human Genome Assembly	20	5,043,598 - 5,048,647		NCBI