IER3 (immediate early response 3) - Rat Genome Database

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Gene: IER3 (immediate early response 3) Homo sapiens
Analyze
Symbol: IER3
Name: immediate early response 3
RGD ID: 1347080
HGNC Page HGNC:5392
Description: Acts upstream of or within DNA damage response. Located in nucleus. Implicated in T-cell non-Hodgkin lymphoma.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: anti-death protein; DIF-2; DIF2; differentiation-dependent gene 2 protein; expressed in pancreatic carcinoma; GLY96; gly96, mouse, homolog of; IEX-1; IEX-1L; IEX1; immediate early protein GLY96; immediate early response 3 protein; immediately early gene X-1; PACAP-responsive gene 1 protein; PRG1; radiation-inducible immediate-early gene IEX-1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38630,743,199 - 30,744,547 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl630,743,199 - 30,744,548 (-)EnsemblGRCh38hg38GRCh38
GRCh37630,710,976 - 30,712,324 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36630,818,955 - 30,820,306 (-)NCBINCBI36Build 36hg18NCBI36
Build 34630,818,955 - 30,820,303NCBI
Celera632,309,116 - 32,310,467 (-)NCBICelera
Cytogenetic Map6p21.33NCBI
HuRef630,510,790 - 30,512,141 (-)NCBIHuRef
CHM1_1630,713,084 - 30,714,431 (-)NCBICHM1_1
T2T-CHM13v2.0630,607,402 - 30,608,750 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2,4-dinitrotoluene  (ISO)
2,5-hexanedione  (ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (EXP)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-methylcholanthrene  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP)
4-hydroxynon-2-enal  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
8-Br-cAMP  (EXP)
acetamide  (ISO)
acrolein  (EXP)
acrylamide  (EXP,ISO)
actinomycin D  (EXP)
afimoxifene  (EXP)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (EXP,ISO)
alpha-pinene  (EXP)
alpha-Zearalanol  (ISO)
amitrole  (ISO)
antimycin A  (EXP)
antirheumatic drug  (EXP)
aristolochic acid A  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (ISO)
atazanavir sulfate  (EXP)
atrazine  (ISO)
azathioprine  (EXP)
azoxystrobin  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
Benzo[ghi]perylene  (ISO)
Benzo[k]fluoranthene  (EXP)
beta-naphthoflavone  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (EXP)
bisphenol F  (ISO)
bromobenzene  (ISO)
butan-1-ol  (EXP)
butanal  (EXP)
butyric acid  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
calciol  (ISO)
calcitriol  (EXP)
camostat  (ISO)
cannabidiol  (EXP,ISO)
carbon nanotube  (ISO)
carmustine  (EXP)
cefaloridine  (ISO)
chenodeoxycholic acid  (EXP)
chlordecone  (ISO)
chloropicrin  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
chrysene  (EXP)
cisplatin  (EXP,ISO)
cobalt dichloride  (EXP)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP)
corticosterone  (ISO)
coumestrol  (EXP)
crocidolite asbestos  (EXP,ISO)
cycloheximide  (EXP)
cyclophosphamide  (EXP)
cyclosporin A  (EXP)
deoxycholic acid  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
dibenz[a,h]anthracene  (EXP)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
dieldrin  (EXP)
diethylstilbestrol  (ISO)
dinophysistoxin 1  (EXP)
dioxygen  (EXP,ISO)
disodium selenite  (EXP)
dorsomorphin  (EXP)
doxorubicin  (EXP)
elemental selenium  (EXP)
ethanol  (EXP)
fenamidone  (ISO)
fluoranthene  (ISO)
flusilazole  (ISO)
flutamide  (ISO)
folic acid  (ISO)
formaldehyde  (EXP)
FR900359  (EXP)
fulvestrant  (EXP)
gamma-hexachlorocyclohexane  (EXP)
gastrin-17  (EXP)
genistein  (ISO)
gentamycin  (ISO)
glafenine  (ISO)
glycochenodeoxycholic acid  (EXP)
glycocholic acid  (EXP)
glycodeoxycholic acid  (EXP)
glyphosate  (ISO)
griseofulvin  (ISO)
hexaconazole  (ISO)
hydrogen peroxide  (EXP)
hydroquinone  (EXP)
hydroxyurea  (ISO)
imidacloprid  (ISO)
Indeno[1,2,3-cd]pyrene  (EXP)
indometacin  (EXP)
irinotecan  (EXP)
isoprenaline  (ISO)
isotretinoin  (EXP)
L-ascorbic acid  (EXP)
L-methionine  (ISO)
lead diacetate  (ISO)
leflunomide  (EXP)
lipopolysaccharide  (EXP,ISO)
maneb  (ISO)
melphalan  (EXP)
mercury dibromide  (EXP)
methimazole  (ISO)
methylisothiazolinone  (EXP)
methylmercury chloride  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide  (EXP)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (EXP)
naphthalene  (EXP,ISO)
nefazodone  (EXP,ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel subsulfide  (ISO)
nickel sulfate  (EXP)
o-anisidine  (EXP)
O-methyleugenol  (EXP)
ochratoxin A  (EXP)
okadaic acid  (ISO)
omeprazole  (EXP)
oxaliplatin  (ISO)
ozone  (EXP)
p-anisidine  (ISO)
p-chloromercuribenzoic acid  (EXP)
paclitaxel  (ISO)
panobinostat  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenanthrene  (EXP)
phenobarbital  (EXP,ISO)
phenylephrine  (ISO)
phenylmercury acetate  (EXP)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phorone  (ISO)
picene  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP)
propanal  (EXP)
quercetin  (EXP)
rac-lactic acid  (EXP)
raloxifene  (EXP)
reactive oxygen species  (ISO)
resveratrol  (EXP)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
SB 431542  (EXP)
selenium atom  (EXP)
silicon dioxide  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sodium hydroxide  (EXP)
Soman  (ISO)
succimer  (ISO)
sulfadimethoxine  (ISO)
sunitinib  (EXP)
superoxide  (ISO)
T-2 toxin  (EXP)
tamibarotene  (EXP)
tamoxifen  (EXP)
temozolomide  (EXP)
tert-butyl hydroperoxide  (EXP)
tetrachloromethane  (ISO)
tetraphene  (EXP)
thiabendazole  (ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
triadimefon  (ISO)
tributylstannane  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP)
triclosan  (EXP)
troglitazone  (EXP)
trovafloxacin  (ISO)
tunicamycin  (EXP)
urethane  (EXP)
valnoctamide  (ISO)
valproic acid  (EXP,ISO)
valpromide  (ISO)
valsartan  (EXP)
vincristine  (EXP)
vorinostat  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Immune cell profiling of COVID-19 patients in the recovery stage by single-cell sequencing. Wen W, etal., Cell Discov. 2020 May 4;6:31. doi: 10.1038/s41421-020-0168-9. eCollection 2020.
4. Development of T-cell lymphomas in Emu-IEX-1 mice. Zhang Y, etal., Oncogene 2003 Oct 9;22(44):6845-51.
Additional References at PubMed
PMID:8125298   PMID:8603392   PMID:8653710   PMID:9196025   PMID:9588170   PMID:9703517   PMID:9781666   PMID:9791001   PMID:9828130   PMID:9878538   PMID:10448082   PMID:11455449  
PMID:11782530   PMID:11844788   PMID:11910304   PMID:12032839   PMID:12356731   PMID:12477932   PMID:12510147   PMID:12682234   PMID:12743274   PMID:12761504   PMID:15120418   PMID:15451437  
PMID:15489334   PMID:15767410   PMID:15781630   PMID:15855159   PMID:16344560   PMID:16456541   PMID:16567805   PMID:16702430   PMID:16960879   PMID:16973576   PMID:17704804   PMID:18026799  
PMID:18191642   PMID:18482256   PMID:18564103   PMID:19152102   PMID:19285955   PMID:19690192   PMID:19773435   PMID:19837266   PMID:19851445   PMID:20467439   PMID:20587610   PMID:20713914  
PMID:20848476   PMID:20934684   PMID:21112119   PMID:21244100   PMID:21250941   PMID:21518511   PMID:21832049   PMID:21873635   PMID:22085302   PMID:23403649   PMID:23455636   PMID:23725081  
PMID:24162774   PMID:24311782   PMID:25036043   PMID:25066273   PMID:25666857   PMID:25684507   PMID:26760575   PMID:26973248   PMID:27736946   PMID:27890615   PMID:28597972   PMID:28931009  
PMID:30249226   PMID:30579899   PMID:30988100   PMID:32296183   PMID:32393512   PMID:34729939  


Genomics

Comparative Map Data
IER3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38630,743,199 - 30,744,547 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl630,743,199 - 30,744,548 (-)EnsemblGRCh38hg38GRCh38
GRCh37630,710,976 - 30,712,324 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36630,818,955 - 30,820,306 (-)NCBINCBI36Build 36hg18NCBI36
Build 34630,818,955 - 30,820,303NCBI
Celera632,309,116 - 32,310,467 (-)NCBICelera
Cytogenetic Map6p21.33NCBI
HuRef630,510,790 - 30,512,141 (-)NCBIHuRef
CHM1_1630,713,084 - 30,714,431 (-)NCBICHM1_1
T2T-CHM13v2.0630,607,402 - 30,608,750 (-)NCBIT2T-CHM13v2.0
Ier3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391736,132,605 - 36,133,803 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1736,132,576 - 36,133,815 (+)EnsemblGRCm39 Ensembl
GRCm381735,821,713 - 35,822,911 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1735,821,684 - 35,822,923 (+)EnsemblGRCm38mm10GRCm38
MGSCv371735,958,658 - 35,959,856 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361735,429,766 - 35,430,964 (+)NCBIMGSCv36mm8
Celera1739,331,780 - 39,332,978 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.7NCBI
Ier3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8202,933,173 - 2,934,377 (-)NCBIGRCr8
mRatBN7.2202,928,378 - 2,929,582 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl202,928,378 - 2,929,583 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx202,979,772 - 2,980,976 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0202,984,757 - 2,985,961 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0203,011,134 - 3,012,338 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0203,438,798 - 3,440,002 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl203,438,798 - 3,440,769 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0205,535,616 - 5,536,820 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4203,076,568 - 3,077,772 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1203,076,800 - 3,077,971 (-)NCBI
Celera20354,289 - 355,493 (-)NCBICelera
Cytogenetic Map20p12NCBI
Ier3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955583730,289 - 731,260 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955583730,353 - 731,301 (-)NCBIChiLan1.0ChiLan1.0
IER3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2545,303,984 - 45,305,784 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1641,266,813 - 41,268,643 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0630,488,162 - 30,489,784 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1631,357,853 - 31,359,205 (-)NCBIpanpan1.1PanPan1.1panPan2
IER3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.112529,002 - 530,328 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl12529,339 - 530,232 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha12666,269 - 667,557 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.012672,140 - 673,428 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl12672,477 - 673,370 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.112530,032 - 531,319 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.012598,936 - 600,223 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.012667,496 - 668,784 (-)NCBIUU_Cfam_GSD_1.0
Ier3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494634,036,216 - 34,037,522 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936837401,524 - 402,741 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936837401,475 - 402,769 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IER3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl723,265,564 - 23,266,827 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1723,265,560 - 23,266,905 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2726,987,529 - 26,988,875 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IER3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11741,712,539 - 41,713,895 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1741,712,528 - 41,714,126 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604430,437,411 - 30,438,758 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ier3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475424,991,690 - 24,992,643 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475424,991,650 - 24,992,645 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in IER3
5 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 6p22.3-21.33(chr6:18120520-30767516)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052180]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052180]|See cases [RCV000052180] Chr6:18120520..30767516 [GRCh38]
Chr6:18120751..30735293 [GRCh37]
Chr6:18228730..30843272 [NCBI36]
Chr6:6p22.3-21.33
pathogenic
GRCh38/hg38 6p25.3-12.3(chr6:156974-46789291)x3 copy number gain See cases [RCV000143497] Chr6:156974..46789291 [GRCh38]
Chr6:156974..46757028 [GRCh37]
Chr6:101974..46864987 [NCBI36]
Chr6:6p25.3-12.3
pathogenic
GRCh37/hg19 6p21.33(chr6:30698482-30853003)x3 copy number gain Breast ductal adenocarcinoma [RCV000207165] Chr6:30698482..30853003 [GRCh37]
Chr6:6p21.33
uncertain significance
NM_003897.4(IER3):c.461C>A (p.Ala154Asp) single nucleotide variant not specified [RCV004317795] Chr6:30743946 [GRCh38]
Chr6:30711723 [GRCh37]
Chr6:6p21.33
uncertain significance
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain See cases [RCV000512067] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain See cases [RCV000510595] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p22.1-q14.1(chr6:29455465-81447367) copy number gain not provided [RCV000767714] Chr6:29455465..81447367 [GRCh37]
Chr6:6p22.1-q14.1
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3 copy number gain not provided [RCV000745403] Chr6:108666..170980171 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3 copy number gain not provided [RCV000745404] Chr6:165632..170919470 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p22.1-21.32(chr6:28130359-32108367)x3 copy number gain not provided [RCV000745592] Chr6:28130359..32108367 [GRCh37]
Chr6:6p22.1-21.32
uncertain significance
GRCh37/hg19 6p21.33(chr6:30695007-30767013)x3 copy number gain not provided [RCV000847349] Chr6:30695007..30767013 [GRCh37]
Chr6:6p21.33
uncertain significance
NM_003897.4(IER3):c.94G>A (p.Gly32Ser) single nucleotide variant not specified [RCV004303774] Chr6:30744425 [GRCh38]
Chr6:30712202 [GRCh37]
Chr6:6p21.33
uncertain significance
NC_000006.11:g.(?_30695893)_(31937492_?)dup duplication not provided [RCV003107453] Chr6:30695893..31937492 [GRCh37]
Chr6:6p21.33
uncertain significance
NC_000006.11:g.28005012_31683185del deletion Megacolon [RCV001290055] Chr6:28005012..31683185 [GRCh37]
Chr6:6p22.1-21.33
likely pathogenic
NC_000006.11:g.(?_30695893)_(36953949_?)dup duplication Proteasome-associated autoinflammatory syndrome 1 [RCV003113679] Chr6:30695893..36953949 [GRCh37]
Chr6:6p21.33-21.2
uncertain significance
NM_003897.4(IER3):c.89G>T (p.Gly30Val) single nucleotide variant not specified [RCV004316109] Chr6:30744430 [GRCh38]
Chr6:30712207 [GRCh37]
Chr6:6p21.33
uncertain significance
NM_003897.4(IER3):c.329C>T (p.Pro110Leu) single nucleotide variant not specified [RCV004341196] Chr6:30744078 [GRCh38]
Chr6:30711855 [GRCh37]
Chr6:6p21.33
uncertain significance
GRCh37/hg19 6p21.33(chr6:30629521-30962674)x3 copy number gain not specified [RCV003986666] Chr6:30629521..30962674 [GRCh37]
Chr6:6p21.33
uncertain significance
NM_003897.4(IER3):c.277A>G (p.Ile93Val) single nucleotide variant not specified [RCV004399973] Chr6:30744130 [GRCh38]
Chr6:30711907 [GRCh37]
Chr6:6p21.33
likely benign
NM_003897.4(IER3):c.71T>A (p.Ile24Asn) single nucleotide variant not specified [RCV004399975] Chr6:30744448 [GRCh38]
Chr6:30712225 [GRCh37]
Chr6:6p21.33
likely benign
NM_003897.4(IER3):c.37A>C (p.Ile13Leu) single nucleotide variant not specified [RCV004399974] Chr6:30744482 [GRCh38]
Chr6:30712259 [GRCh37]
Chr6:6p21.33
uncertain significance
NM_003897.4(IER3):c.418G>T (p.Asp140Tyr) single nucleotide variant not specified [RCV004348743] Chr6:30743989 [GRCh38]
Chr6:30711766 [GRCh37]
Chr6:6p21.33
uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:607
Count of miRNA genes:287
Interacting mature miRNAs:306
Transcripts:ENST00000259874, ENST00000376377
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH91431  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37630,711,121 - 30,711,292UniSTSGRCh37
Build 36630,819,100 - 30,819,271RGDNCBI36
Celera632,309,261 - 32,309,432RGD
Cytogenetic Map6p21.3UniSTS
HuRef630,510,935 - 30,511,106UniSTS
GeneMap99-GB4 RH Map6119.6UniSTS
G62116  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37630,711,002 - 30,711,123UniSTSGRCh37
Build 36630,818,981 - 30,819,102RGDNCBI36
Celera632,309,142 - 32,309,263RGD
Cytogenetic Map6p21.3UniSTS
HuRef630,510,816 - 30,510,937UniSTS
PMC135646P5  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37630,712,311 - 30,712,466UniSTSGRCh37
Build 36630,820,290 - 30,820,445RGDNCBI36
Celera632,310,451 - 32,310,606RGD
Cytogenetic Map6p21.3UniSTS
HuRef630,512,125 - 30,512,280UniSTS
PMC154982P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37630,711,745 - 30,712,330UniSTSGRCh37
Build 36630,819,724 - 30,820,309RGDNCBI36
Celera632,309,885 - 32,310,470RGD
Cytogenetic Map6p21.3UniSTS
HuRef630,511,559 - 30,512,144UniSTS
PMC154982P2  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37630,711,138 - 30,711,288UniSTSGRCh37
Build 36630,819,117 - 30,819,267RGDNCBI36
Celera632,309,278 - 32,309,428RGD
Cytogenetic Map6p21.3UniSTS
HuRef630,510,952 - 30,511,102UniSTS
PMC154982P3  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37630,711,907 - 30,712,203UniSTSGRCh37
Build 36630,819,886 - 30,820,182RGDNCBI36
Celera632,310,047 - 32,310,343RGD
Cytogenetic Map6p21.3UniSTS
HuRef630,511,721 - 30,512,017UniSTS
PMC98754P3  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37630,711,727 - 30,712,088UniSTSGRCh37
Build 36630,819,706 - 30,820,067RGDNCBI36
Celera632,309,867 - 32,310,228RGD
Cytogenetic Map6p21.3UniSTS
HuRef630,511,541 - 30,511,902UniSTS
IER3_130  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37630,710,906 - 30,711,729UniSTSGRCh37
Build 36630,818,885 - 30,819,708RGDNCBI36
Celera632,309,046 - 32,309,869RGD
HuRef630,510,720 - 30,511,543UniSTS
STS-AA034911  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37630,711,008 - 30,711,157UniSTSGRCh37
Build 36630,818,987 - 30,819,136RGDNCBI36
Celera632,309,148 - 32,309,297RGD
Cytogenetic Map6p21.3UniSTS
HuRef630,510,822 - 30,510,971UniSTS
GeneMap99-GB4 RH Map6118.0UniSTS
NCBI RH Map6426.2UniSTS
RH78215  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37630,711,596 - 30,711,721UniSTSGRCh37
Build 36630,819,575 - 30,819,700RGDNCBI36
Celera632,309,736 - 32,309,861RGD
Cytogenetic Map6p21.3UniSTS
HuRef630,511,410 - 30,511,535UniSTS
GeneMap99-GB4 RH Map6119.27UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 18 15 4 3 2 17 2 3 18 39 1 17 8
Medium 2401 2828 1598 541 1718 385 3511 1401 1814 395 1118 1503 171 1 1035 2104 6 2
Low 19 146 124 80 216 78 824 788 1915 21 324 67 3 152 671
Below cutoff 1 2 15 5 6 5 4 5

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_003897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB088101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB103607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB202099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF039067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF071596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF083421 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ227914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK222588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK314162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL662797 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL662848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL845353 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BA000025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC000844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC005080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM915952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT006703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX248307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR936878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT009501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA893782 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY500405 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY500406 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S81914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X96438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y14551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y16736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENST00000259874   ⟹   ENSP00000259874
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl630,743,199 - 30,744,547 (-)Ensembl
RefSeq Acc Id: ENST00000376377   ⟹   ENSP00000365557
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl630,743,199 - 30,744,548 (-)Ensembl
RefSeq Acc Id: NM_003897   ⟹   NP_003888
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38630,743,199 - 30,744,547 (-)NCBI
GRCh37630,710,976 - 30,712,327 (-)ENTREZGENE
Build 36630,818,955 - 30,820,306 (-)NCBI Archive
HuRef630,510,790 - 30,512,141 (-)ENTREZGENE
CHM1_1630,713,084 - 30,714,431 (-)NCBI
T2T-CHM13v2.0630,607,402 - 30,608,750 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_003888 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB36278 (Get FASTA)   NCBI Sequence Viewer  
  AAC32558 (Get FASTA)   NCBI Sequence Viewer  
  AAC33793 (Get FASTA)   NCBI Sequence Viewer  
  AAC72344 (Get FASTA)   NCBI Sequence Viewer  
  AAH00844 (Get FASTA)   NCBI Sequence Viewer  
  AAH05080 (Get FASTA)   NCBI Sequence Viewer  
  AAP35349 (Get FASTA)   NCBI Sequence Viewer  
  AQY76892 (Get FASTA)   NCBI Sequence Viewer  
  AQY76893 (Get FASTA)   NCBI Sequence Viewer  
  BAB63319 (Get FASTA)   NCBI Sequence Viewer  
  BAC54933 (Get FASTA)   NCBI Sequence Viewer  
  BAD96308 (Get FASTA)   NCBI Sequence Viewer  
  BAE78619 (Get FASTA)   NCBI Sequence Viewer  
  BAF31268 (Get FASTA)   NCBI Sequence Viewer  
  BAG36846 (Get FASTA)   NCBI Sequence Viewer  
  CAA65304 (Get FASTA)   NCBI Sequence Viewer  
  CAA74886 (Get FASTA)   NCBI Sequence Viewer  
  CAA76350 (Get FASTA)   NCBI Sequence Viewer  
  EAX03329 (Get FASTA)   NCBI Sequence Viewer  
  EAX03330 (Get FASTA)   NCBI Sequence Viewer  
  EAX03331 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000259874
  ENSP00000259874.5
  ENSP00000365557.2
  ENSP00000373054.4
  ENSP00000383354.1
  ENSP00000394148.1
  ENSP00000397956.2
  ENSP00000398052.1
  ENSP00000398139.2
  ENSP00000406245.2
  ENSP00000411106.1
  ENSP00000412283.2
  ENSP00000412861.1
GenBank Protein P46695 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_003888   ⟸   NM_003897
- UniProtKB: Q92691 (UniProtKB/Swiss-Prot),   Q5SU30 (UniProtKB/Swiss-Prot),   Q93044 (UniProtKB/Swiss-Prot),   P46695 (UniProtKB/Swiss-Prot),   A0A1U9X7X2 (UniProtKB/TrEMBL),   Q5ST77 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000365557   ⟸   ENST00000376377
RefSeq Acc Id: ENSP00000259874   ⟸   ENST00000259874

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P46695-F1-model_v2 AlphaFold P46695 1-156 view protein structure

Promoters
RGD ID:6872424
Promoter ID:EPDNEW_H9377
Type:initiation region
Name:IER3_1
Description:immediate early response 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38630,744,547 - 30,744,607EPDNEW
RGD ID:6804369
Promoter ID:HG_KWN:52859
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid
Transcripts:ENST00000376382,   OTTHUMT00000076578
Position:
Human AssemblyChrPosition (strand)Source
Build 36630,819,824 - 30,820,324 (-)MPROMDB
RGD ID:6853320
Promoter ID:EP74485
Type:multiple initiation site
Name:HS_IER3
Description:Immediate early response 3.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Mammalian gene collection (MGC) full-length cDNA cloning
Position:
Human AssemblyChrPosition (strand)Source
Build 36630,820,290 - 30,820,350EPD

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:5392 AgrOrtholog
COSMIC IER3 COSMIC
Ensembl Genes ENSG00000137331 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSG00000206478 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSG00000227231 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSG00000230128 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSG00000235030 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSG00000237155 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000259874 ENTREZGENE
  ENST00000259874.6 UniProtKB/Swiss-Prot
  ENST00000376377.2 UniProtKB/TrEMBL
  ENST00000383560.4 UniProtKB/Swiss-Prot
  ENST00000400509.1 UniProtKB/TrEMBL
  ENST00000416336.1 UniProtKB/TrEMBL
  ENST00000416884.2 UniProtKB/Swiss-Prot
  ENST00000429592.1 UniProtKB/TrEMBL
  ENST00000435856.2 UniProtKB/Swiss-Prot
  ENST00000436988.1 UniProtKB/TrEMBL
  ENST00000439190.2 UniProtKB/Swiss-Prot
  ENST00000446599.1 UniProtKB/TrEMBL
  ENST00000450236.2 UniProtKB/Swiss-Prot
GTEx ENSG00000137331 GTEx
  ENSG00000206478 GTEx
  ENSG00000227231 GTEx
  ENSG00000230128 GTEx
  ENSG00000235030 GTEx
  ENSG00000237155 GTEx
HGNC ID HGNC:5392 ENTREZGENE
Human Proteome Map IER3 Human Proteome Map
InterPro IEX-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:8870 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 8870 ENTREZGENE
OMIM 602996 OMIM
PANTHER PTHR16915 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RADIATION-INDUCIBLE IMMEDIATE-EARLY GENE IEX-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA29639 PharmGKB
PRINTS GENEIEX1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1U9X7X2 ENTREZGENE, UniProtKB/TrEMBL
  IEX1_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q5ST77 ENTREZGENE, UniProtKB/TrEMBL
  Q5ST79_HUMAN UniProtKB/TrEMBL
  Q5SU30 ENTREZGENE
  Q92691 ENTREZGENE
  Q93044 ENTREZGENE
UniProt Secondary Q5SU30 UniProtKB/Swiss-Prot
  Q92691 UniProtKB/Swiss-Prot
  Q93044 UniProtKB/Swiss-Prot