IER3 (immediate early response 3)

Gene: IER3 (immediate early response 3) Chlorocebus sabaeus

Analyze

Symbol:

IER3

Name:

immediate early response 3

RGD ID:

18751297

Description:

INVOLVED IN DNA damage response (ortholog); glycolytic process (ortholog); intrinsic apoptotic signaling pathway in response to DNA damage (ortholog); ASSOCIATED WITH Arsenic Poisoning (ortholog); COVID-19 (ortholog); hypertension (ortholog); FOUND IN mitochondrion (inferred); nucleus (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

radiation-inducible immediate-early gene IEX-1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	41,712,539 - 41,713,895 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	17	41,712,528 - 41,714,126 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666044	30,437,411 - 30,438,758 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Arsenic Poisoning (ISO)

COVID-19 (ISO)

hypertension (ISO)

irritant dermatitis (ISO)

megacolon (ISO)

proteasome-associated autoinflammatory syndrome 1 (ISO)

skin disease (ISO)

T-cell non-Hodgkin lymphoma (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

DNA damage response (IEA,ISO)

glycolytic process (IEA,ISO)

intrinsic apoptotic signaling pathway in response to DNA damage (IEA,ISO)

mitotic G2 DNA damage checkpoint signaling (IEA,ISO)

negative regulation of apoptotic process (IEA)

negative regulation of glycolytic process (IEA,ISO)

negative regulation of inflammatory response (IEA,ISO)

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway (IEA,ISO)

negative regulation of systemic arterial blood pressure (IEA,ISO)

positive regulation of protein catabolic process (IEA,ISO)

regulation of DNA repair (IEA,ISO)

regulation of nucleocytoplasmic transport (IEA,ISO)

regulation of reactive oxygen species metabolic process (IEA,ISO)

response to protozoan (IEA,ISO)

Cellular Component

mitochondrion (IEA)

nucleus (IEA)

Molecular Function

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

IER3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	41,712,539 - 41,713,895 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	17	41,712,528 - 41,714,126 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666044	30,437,411 - 30,438,758 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

IER3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	30,743,199 - 30,744,547 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	30,743,199 - 30,744,548 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	30,710,976 - 30,712,324 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	30,818,955 - 30,820,306 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	30,818,955 - 30,820,303	NCBI
Celera	6	32,309,116 - 32,310,467 (-)	NCBI		Celera
Cytogenetic Map	6	p21.33	NCBI
HuRef	6	30,510,790 - 30,512,141 (-)	NCBI		HuRef
CHM1_1	6	30,713,084 - 30,714,431 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	30,607,402 - 30,608,750 (-)	NCBI		T2T-CHM13v2.0

Ier3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	36,132,605 - 36,133,803 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	36,132,576 - 36,133,815 (+)	Ensembl		GRCm39 Ensembl
GRCm38	17	35,821,713 - 35,822,911 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	35,821,684 - 35,822,923 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	35,958,658 - 35,959,856 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	35,429,766 - 35,430,964 (+)	NCBI		MGSCv36	mm8
Celera	17	39,331,780 - 39,332,978 (+)	NCBI		Celera
Cytogenetic Map	17	B1	NCBI
cM Map	17	18.7	NCBI

Ier3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	2,933,173 - 2,934,377 (-)	NCBI		GRCr8
mRatBN7.2	20	2,928,378 - 2,929,582 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	2,928,378 - 2,929,583 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	2,979,772 - 2,980,976 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	2,984,757 - 2,985,961 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	3,011,134 - 3,012,338 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	3,438,798 - 3,440,002 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	3,438,798 - 3,440,769 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	5,535,616 - 5,536,820 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	3,076,568 - 3,077,772 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	20	3,076,800 - 3,077,971 (-)	NCBI
Celera	20	354,289 - 355,493 (-)	NCBI		Celera
Cytogenetic Map	20	p12	NCBI

Ier3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955583	730,289 - 731,260 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955583	730,353 - 731,301 (-)	NCBI	ChiLan1.0	ChiLan1.0

IER3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	45,303,984 - 45,305,784 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	41,266,813 - 41,268,643 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	30,488,162 - 30,489,784 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	31,357,853 - 31,359,205 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

IER3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	529,002 - 530,328 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	12	529,339 - 530,232 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	12	666,269 - 667,557 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	12	672,140 - 673,428 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	12	672,477 - 673,370 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	12	530,032 - 531,319 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	12	598,936 - 600,223 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	12	667,496 - 668,784 (-)	NCBI		UU_Cfam_GSD_1.0

Ier3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	34,036,216 - 34,037,522 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936837	401,524 - 402,741 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936837	401,475 - 402,769 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

IER3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	23,265,564 - 23,266,827 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	23,265,560 - 23,266,905 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	26,987,529 - 26,988,875 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Ier3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624754	24,991,690 - 24,992,643 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624754	24,991,650 - 24,992,645 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	endocrine system	hemolymphoid system	nervous system
High
Medium	29		13
Low	7	18	47
Below cutoff		2

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007973201	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC241600	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACDXN010000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCSAT00000006347 ⟹ ENSCSAP00000004552

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	17	41,712,528 - 41,714,126 (+)	Ensembl

RefSeq Acc Id:

XM_007973201 ⟹ XP_007971392

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	17	41,712,539 - 41,713,895 (+)	NCBI
Vero_WHO_p1.0	NW_023666044	30,437,411 - 30,438,758 (-)	NCBI

Sequence:

show sequence

TCTGCCGGCAGCCGGCCTGCACTTGGCCTTACACTCCGCTCAGGGCACCATGTGTCACTCTCGC
AGCTGCCACCCGACCATGACCATCCTGCAGGCCCCGACCCCGGCCCCCTCCACCAACCCGGGAC
CCCGGCGGGGCTCCGGTCCTGAGATCTTCACCTTCGACCCTCTCCCGGAGCCCGCAGCGGTCCC
CGCCGGGCGCCCCAGCACCTCTCGCGGGCACCGAAAGCGCAGCCGCAGGGTTCTCTACCCTCGA
GTGGTCCGGCGCCAGCTGCCAGTCGAGGAACCGAACCCAGCCAAAAGGCTTCTTTTTCTGCTGC
TCACCATCGTCTTCTGCCAGATCCTGATAGCTGAAGAGGGCGTGCCAGCGCCCCTGCCTCCGGA
GGACGCCCCCAGCACCGCATCCCAGGCGCCCACCCCTGTGCCCCCGGTCCTCGAGCCCTTTAAT
CTGACTTCGGAGCCCTCGGACTACGCTTTGGACCTCAGCACTTTCCTCCAGCAACACCCAGCCG
CCTTCTGACTTTGACTCCCCGCACTCCCCAAAAAGAATCCGAAAAACCGCAAAGAAACACCAGG
CGTACCTGGTGCGTGAGAGCGTATCCCAAACTGGGACTTCCGAGGCAACTTGAACTCAGAACAC
TACAGCGGAGACGACACCCAGTGCTTGAGGCGGGACTGAGGCGCACATAGACCGAGGCACAGCC
AAGCTGGGGCTAGGCCCAGTGGGAATTAGAGCGTCGTTAATTTATTTCTTATTGCTCCTAATTA
ATATTTATATGTATTTATGTACGTCCTCCTAGGTGATGAAGGGGTGTACGTAATATTTATTTTA
ACTTATGCAAGGGTGTGAGATGTTCCCCCTGCTGTAAACACAGGTCTCTTGGTATTTATTGAGC
TTTGTGGGACTGGTGGAGGCAGGACACCTGGAACTGCGGCAGAGTAGGAGAAGAAGTGGGGAGG
ACTCAGGTGGGGGAGGACGTTCCGGCTGGGATGAAGTCTGGTGGTGGGTCGTAAGTTTAGGAGG
TGACACTGCATCCTCCAGCATCTCAGCTCCGTCTGTCTACTGTGTGAGACTTCGGCGGACCATT
GGGAATGAGATCCGTGAGATCCTTTGATCTTCTTGAAGTCGCCTTTAGGGAGAGGCTGCGGGGT
AGAGGGTTGGGGGTTGGTGGGCTGTCACGGGGCGACTGTCGAGATTGCCCGGTATGTTCTGTGA
ACACAAATAAACTTGATTTACTGTCTGCA

hide sequence

Protein Sequences


Protein RefSeqs	XP_007971392	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000004552
	ENSCSAP00000004552.1

RefSeq Acc Id:	XP_007971392 ⟸ XM_007973201
- UniProtKB:	A0A0D9R7G3 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCSAP00000004552 ⟸ ENSCSAT00000006347

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000008293	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000006347.1	UniProtKB/TrEMBL
InterPro	IEX-1	UniProtKB/TrEMBL
KEGG Report	csab:103221817	UniProtKB/TrEMBL
NCBI Gene	IER3	ENTREZGENE
PANTHER	PTHR16915	UniProtKB/TrEMBL
	RADIATION-INDUCIBLE IMMEDIATE-EARLY GENE IEX-1	UniProtKB/TrEMBL
PRINTS	GENEIEX1	UniProtKB/TrEMBL
UniProt	A0A0D9R7G3	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

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