Gene: EIF4G1 (eukaryotic translation initiation factor 4 gamma, 1)  Homo sapiens
Symbol: EIF4G1
Name: eukaryotic translation initiation factor 4 gamma, 1
Description: The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq, Aug 2010]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DKFZp686A1451; eIF-4-gamma 1; eIF-4G 1; eIF-4G1; EIF-4G1; EIF4-gamma; EIF4F; EIF4G; EIF4GI; eucaryotic translation initiation factor 4G; eukaryotic translation initiation factor 4 gamma 1; OTTHUMP00000210577; OTTHUMP00000210579; OTTHUMP00000210583; OTTHUMP00000210585; OTTHUMP00000210586; OTTHUMP00000210587; OTTHUMP00000210588; OTTHUMP00000210589; OTTHUMP00000210595; OTTHUMP00000210602; OTTHUMP00000210603; OTTHUMP00000233293; OTTHUMP00000233411; p220; P220; PARK18
Orthologs: Mus musculus : Eif4g1 (eukaryotic translation initiation factor 4, gamma 1)  MGI
Rattus norvegicus : Eif4g1 (eukaryotic translation initiation factor 4 gamma, 1)
Latest Assembly: Human Genome Assembly GRCh37
Position:
MapChrPositionStrandSource
Human Alternate Assembly CHM1_13183,898,515 - 183,919,383+NCBI
Human Genome Assembly HuRef3181,439,248 - 181,459,772+NCBI
Human Genome Assembly GRCh373184,032,283 - 184,053,146+NCBI
Human Genome Assembly Build 363185,515,050 - 185,535,840+NCBI
Human Cytogenetic Map3q27-qter NCBI
Model

Launch Genome Browser (GBrowse) : build 36 (hg18) build 37 (hg19)

Annotation    (Toggle Detail/Summary View)

Gene-Chemical Interaction Annotations
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References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Human Genome Assembly GRCh37)

Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
Nomenclature History
  
More on EIF4G1
Entrez Gene
Ensembl Gene
Genome Browser: (hg18) (hg19)
HGNC Report
NCBI Map Viewer
Vista
Vista + UCSC

RGD Object Information
RGD ID: 1314591
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2013-04-16
Status: ACTIVE



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