Gene: HLA-DRB1 (major histocompatibility complex, class II, DR beta 1)  Homo sapiens
Symbol: HLA-DRB1
Name: major histocompatibility complex, class II, DR beta 1
Description: HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DR-16; DR-8; DR1; DR16; DR5; DR8; DRB1; DRw10; DRw11; DRw8; DW2.2/DR2.2; FLJ75017; FLJ76359; HLA class II antigen beta chain; HLA class II histocompatibility antigen, DR-1 beta chain; HLA-DR-beta 1; HLA-DR1B; HLA-DRB; HLA-DRB1*; human leucocyte antigen DRB1; leucocyte antigen DR beta 1 chain; leucocyte antigen DRB1; lymphocyte antigen DRB1; major histocompatibility complex, class II, DR beta 1; MHC class II antigen; MHC class II antigen HLA-DR13; MHC class II HLA-DR beta 1 chain; MHC class II HLA-DR-beta cell surface glycoprotein; MHC class II HLA-DRw10-beta; OTTHUMP00000029282; SS1
Orthologs: Mus musculus : H2-Eb1 (histocompatibility 2, class II antigen E beta)  MGI
Rattus norvegicus : RT1-Db1 (RT1 class II, locus Db1)
Is Marker For: QTLs:   MULTSCL5_H   MULTSCL19_H  
Latest Assembly: Human Genome Assembly GRCh37
Position:
MapChrPositionStrandSource
Human Alternate Assembly CHM1_1632,464,427 - 32,475,491-NCBI
Human Genome Assembly HuRef632,290,761 - 32,302,955-NCBI
Human Genome Assembly GRCh37632,546,546 - 32,557,613-NCBI
Human Genome Assembly Build 36632,654,527 - 32,665,559-NCBI
Human Cytogenetic Map6p21.3 NCBI
Human Genome Assembly632,654,526 - 32,665,559 NCBI
Model

Launch Genome Browser (GBrowse) : build 36 (hg18) build 37 (hg19)

Annotation    (Toggle Detail/Summary View)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Human Genome Assembly GRCh37)

Sequence

Nucleotide Sequences