NR1I2 (nuclear receptor subfamily 1, group I, member 2)

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Keyword

Gene: NR1I2 (nuclear receptor subfamily 1, group I, member 2) Homo sapiens

Symbol:

NR1I2

Name:

nuclear receptor subfamily 1, group I, member 2

Description:

This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq, Jul 2008]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

BXR; nuclear receptor subfamily 1 group I member 2; nuclear receptor subfamily 1, group 1, member 2; ONR1; orphan nuclear receptor PAR1; orphan nuclear receptor PXR; OTTHUMP00000215173; OTTHUMP00000215174; OTTHUMP00000215175; PAR; PAR1; PAR2; PARq; pregnane X nuclear receptor variant 2; pregnane X receptor; PRR; PXR; SAR; steroid and xenobiotic receptor; SXR

Orthologs:

Mus musculus : Nr1i2 (nuclear receptor subfamily 1, group I, member 2) MGI
Rattus norvegicus : Nr1i2 (nuclear receptor subfamily 1, group I, member 2)

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	3	119,466,468 - 119,504,552	+	NCBI
Human Genome Assembly HuRef	3	116,874,950 - 116,913,074	+	NCBI
Human Genome Assembly GRCh37	3	119,499,331 - 119,537,332	+	NCBI
Human Genome Assembly Build 36	3	120,982,021 - 121,020,022	+	NCBI
Human Cytogenetic Map	3	q12-q13.3		NCBI
Human Genome Assembly	3	120,982,020 - 121,020,021		NCBI