ABCB4 (ATP-binding cassette, sub-family B (MDR/TAP), member 4)

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Keyword

Gene: ABCB4 (ATP-binding cassette, sub-family B (MDR/TAP), member 4) Homo sapiens

Symbol:

ABCB4

Name:

ATP-binding cassette, sub-family B (MDR/TAP), member 4

Description:

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate. The function of this protein has not yet been determined; however, it may involve transport of phospholipids from liver hepatocytes into bile. Alternative splicing of this gene results in several products of undetermined function. [provided by RefSeq, Jul 2008]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

ABC21; ATP-binding cassette sub-family B member 4; GBD1; ICP3; MDR2; MDR2/3; MDR3; multidrug resistance protein 3; multiple drug resistance 3; OTTHUMP00000161613; OTTHUMP00000206137; OTTHUMP00000210458; P glycoprotein 3/multiple drug resistance 3; P-glycoprotein 3; P-glycoprotein-3/multiple drug resistance-3; PFIC-3; PGY3

Orthologs:

Mus musculus : Abcb4 (ATP-binding cassette, sub-family B (MDR/TAP), member 4) MGI
Rattus norvegicus : Abcb4 (ATP-binding cassette, subfamily B (MDR/TAP), member 4)

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	7	90,338,600 - 90,412,251	-	NCBI
Human Alternate Assembly CRA_TCAGchr7v2	7	86,362,871 - 86,436,531	-	NCBI
Human Genome Assembly HuRef	7	81,642,357 - 81,716,022	-	NCBI
Human Genome Assembly GRCh37	7	87,031,361 - 87,105,019	-	NCBI
Human Genome Assembly Build 36	7	86,869,297 - 86,942,955	-	NCBI
Human Cytogenetic Map	7	q21.1		NCBI
Human Genome Assembly	7	86,676,016 - 86,754,402		NCBI