GCLC (glutamate-cysteine ligase, catalytic subunit)

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Keyword

Gene: GCLC (glutamate-cysteine ligase, catalytic subunit) Homo sapiens

Symbol:

GCLC

Name:

glutamate-cysteine ligase, catalytic subunit

Description:

Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.[provided by RefSeq, Oct 2010]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

gamma-ECS; gamma-glutamylcysteine synthetase; GCL; GCS; GCS heavy chain; GLCL; GLCLC; glutamate--cysteine ligase catalytic subunit; glutamate-cysteine ligase catalytic subunit; OTTHUMP00000217803

Orthologs:

Mus musculus : Gclc (glutamate-cysteine ligase, catalytic subunit) MGI
Rattus norvegicus : Gclc (glutamate-cysteine ligase, catalytic subunit)

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	6	53,273,676 - 53,321,466	-	NCBI
Human Genome Assembly HuRef	6	53,193,712 - 53,241,391	-	NCBI
Human Genome Assembly GRCh37	6	53,362,139 - 53,409,927	-	NCBI
Human Genome Assembly Build 36	6	53,470,098 - 53,517,790	-	NCBI
Human Cytogenetic Map	6	p12		NCBI
Human Genome Assembly	6	53,470,097 - 53,517,790		NCBI