DRD1 (dopamine receptor D1) - Rat Genome Database

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Gene: DRD1 (dopamine receptor D1) Homo sapiens
Analyze
Symbol: DRD1
Name: dopamine receptor D1
RGD ID: 70828
HGNC Page HGNC:3020
Description: Enables several functions, including G-protein alpha-subunit binding activity; arrestin family protein binding activity; and dopamine binding activity. Involved in G protein-coupled receptor signaling pathway and positive regulation of release of sequestered calcium ion into cytosol. Located in ciliary membrane and non-motile cilium. Part of G protein-coupled receptor complex. Implicated in hypertension and kidney failure. Biomarker of Alzheimer's disease.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: D(1A) dopamine receptor; D1R; DADR; dopamine D1 receptor; DRD1A
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385175,440,036 - 175,444,182 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5175,440,036 - 175,444,182 (-)EnsemblGRCh38hg38GRCh38
GRCh375174,867,039 - 174,871,185 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365174,800,281 - 174,803,769 (-)NCBINCBI36Build 36hg18NCBI36
Build 345174,800,642 - 174,803,769NCBI
Celera5170,906,676 - 170,910,164 (-)NCBICelera
Cytogenetic Map5q35.2NCBI
HuRef5169,967,086 - 169,970,574 (-)NCBIHuRef
CHM1_15174,300,099 - 174,303,587 (-)NCBICHM1_1
T2T-CHM13v2.05175,983,814 - 175,987,960 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(1R,3S)-3-(adamantan-1-yl)-1-(aminomethyl)-3,4-dihydroisochromene-5,6-diol hydrochloride  (EXP)
(R)-noradrenaline  (ISO)
(S)-nicotine  (ISO)
1-bromopropane  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-[4-[3-[2-(trifluoromethyl)-9-thioxanthenylidene]propyl]-1-piperazinyl]ethanol  (EXP)
3',5'-cyclic AMP  (EXP,ISO)
3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acrylamide  (ISO)
afimoxifene  (EXP)
aluminium atom  (ISO)
aluminium(0)  (ISO)
amitriptyline  (ISO)
amlodipine  (ISO)
ammonium chloride  (ISO)
amoxapine  (ISO)
amphetamine  (ISO)
Anhydroecgonine methyl ester  (ISO)
apomorphine  (EXP,ISO)
aprindine  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
Bardoxolone methyl  (EXP)
benserazide  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
bisphenol F  (ISO)
Boldine  (ISO)
butanal  (EXP)
cadmium atom  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
chlorpromazine  (EXP)
chlorpyrifos  (ISO)
clozapine  (EXP,ISO)
cocaine  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (ISO)
decabromodiphenyl ether  (ISO)
dibutyl phthalate  (ISO)
dichlorine  (ISO)
diclofenac  (ISO)
diltiazem  (ISO)
dioxygen  (ISO)
dizocilpine maleate  (ISO)
domperidone  (ISO)
dopamine  (EXP,ISO)
etafenone  (ISO)
ethanol  (ISO)
ethyl acetate  (ISO)
eugenol  (ISO)
fenoldopam  (ISO)
flunarizine  (ISO)
flupenthixol  (EXP)
fonofos  (EXP)
formaldehyde  (ISO)
furan  (ISO)
gadolinium atom  (ISO)
gamma-aminobutyric acid  (ISO)
genistein  (ISO)
glyphosate  (ISO)
haloperidol  (EXP,ISO)
iron atom  (ISO)
iron(0)  (ISO)
isoquinolines  (EXP)
lanthanum atom  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
loxapine  (ISO)
manganese(II) chloride  (ISO)
manidipine  (ISO)
melatonin  (ISO)
melevodopa  (ISO)
methamphetamine  (EXP,ISO)
methoxychlor  (ISO)
methylmercury chloride  (ISO)
methylphenidate  (ISO)
mirtazapine  (ISO)
morphine  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-allyl-1-phenyl-2,3,4,5-tetrahydro-3-benzazepine-7,8-diol  (EXP)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-6-chloro-1-(3-methylphenyl)-2,3,4,5-tetrahydro-3-benzazepine-7,8-diol  (EXP)
nicotine  (ISO)
Nonylphenol  (ISO)
olanzapine  (ISO)
ouabain  (EXP,ISO)
oxidopamine  (ISO)
ozone  (ISO)
paracetamol  (ISO)
parathion  (EXP)
pentetrazol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pergolide  (EXP)
phencyclidine  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
procymidone  (ISO)
Propiverine  (ISO)
quercetin  (ISO)
quinolinic acid  (ISO)
reserpine  (ISO)
resveratrol  (EXP)
rotenone  (ISO)
SCH 23390  (EXP,ISO)
serotonin  (ISO)
sertraline  (ISO)
simvastatin  (ISO)
SKF 38393  (EXP,ISO)
sodium arsenite  (ISO)
spiperone  (ISO)
sunitinib  (EXP)
terbufos  (EXP)
tetrahydropalmatine  (EXP)
valproic acid  (EXP,ISO)
verapamil  (ISO)
XL147  (ISO)
zinc acetate  (ISO)
zinc dichloride  (ISO)
zinc sulfate  (ISO)
zonisamide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating adrenergic receptor signaling pathway  (IBA,IEA)
adenylate cyclase-activating dopamine receptor signaling pathway  (IDA,IEA,IMP,ISO)
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IDA,IEA)
adult walking behavior  (IEA,ISO,ISS)
associative learning  (IEA,ISO)
astrocyte development  (IEA,ISO)
behavioral fear response  (IEA,ISO)
behavioral response to cocaine  (IEA,ISO)
calcium-mediated signaling  (ISO)
cell migration  (IEA,ISO)
cellular response to catecholamine stimulus  (IDA)
cellular response to hypoxia  (ISO)
cellular response to insulin stimulus  (ISO)
cerebral cortex GABAergic interneuron migration  (IEA,ISO,ISS)
conditioned taste aversion  (IEA,ISO)
dentate gyrus development  (IEA,ISO)
dopamine metabolic process  (IC)
dopamine receptor signaling pathway  (IBA,IEA,ISO)
dopamine transport  (IEA,ISO)
eating behavior  (ISO)
feeding behavior  (IEA,ISO)
G protein-coupled receptor signaling pathway  (IEA,ISO)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  (IDA)
glucose import  (IEA,ISO)
grooming behavior  (IEA,ISO)
habituation  (IEA,ISO)
hippocampus development  (IEA,ISO)
intracellular protein transport  (ISO)
learning  (IEA,ISO)
locomotory behavior  (IEA,ISO)
long-term synaptic depression  (IEA,ISO)
long-term synaptic potentiation  (IEA,ISO)
maternal behavior  (IEA,ISO)
mating behavior  (IEA,ISO,ISS)
memory  (IEA,ISO)
modification of postsynaptic structure  (IEA)
muscle contraction  (IEA,ISO)
negative regulation of cell migration  (ISO)
negative regulation of cellular response to hypoxia  (ISO)
negative regulation of circadian sleep/wake cycle, sleep  (ISO)
negative regulation of protein kinase activity  (ISO)
negative regulation of synaptic transmission  (ISO)
neuron migration  (IEA,ISO)
neuronal action potential  (IEA,ISO)
operant conditioning  (IEA,ISO)
orbitofrontal cortex development  (ISO)
peristalsis  (IEA,ISO)
phospholipase C-activating dopamine receptor signaling pathway  (IDA,IEA,ISO)
positive regulation of cell migration  (ISS)
positive regulation of feeding behavior  (ISO)
positive regulation of long-term synaptic potentiation  (ISO)
positive regulation of MAPK cascade  (IBA)
positive regulation of membrane potential  (ISO)
positive regulation of neuron migration  (IEA,ISO)
positive regulation of potassium ion transport  (ISS)
positive regulation of protein phosphorylation  (ISO)
positive regulation of release of sequestered calcium ion into cytosol  (IDA)
positive regulation of synaptic transmission, glutamatergic  (IEA,ISO,ISS)
postsynaptic modulation of chemical synaptic transmission  (ISO)
prepulse inhibition  (ISO,ISS)
presynaptic modulation of chemical synaptic transmission  (IEA)
protein import into nucleus  (IEA,ISO)
regulation of dopamine metabolic process  (IEA,ISO)
regulation of dopamine uptake involved in synaptic transmission  (IC)
regulation of monoatomic ion transport  (ISO)
regulation of protein phosphorylation  (IEA,ISO)
regulation of vasoconstriction  (ISO)
response to activity  (ISO)
response to amino acid  (ISO)
response to amphetamine  (IEA,ISO)
response to cocaine  (IEA,ISO)
response to estradiol  (ISO)
response to ethanol  (ISO)
response to food  (ISO)
response to nicotine  (ISO)
response to organic cyclic compound  (ISO)
response to organonitrogen compound  (ISO)
response to retinoic acid  (ISO)
response to steroid hormone  (ISO)
response to xenobiotic stimulus  (IEA,ISO,ISS)
sensitization  (IEA,ISO)
social behavior  (ISO)
startle response  (ISO)
striatum development  (IEA,ISO)
synapse assembly  (ISS)
synaptic transmission, dopaminergic  (IEA,ISO)
synaptic transmission, glutamatergic  (IEA,ISO)
temperature homeostasis  (IEA,ISO)
transmission of nerve impulse  (IEA,ISO,ISS)
vasodilation  (IEA)
visual learning  (IEA,ISO,ISS)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
alfentanil pharmacodynamics pathway  (EXP)
bupivacaine pharmacodynamics pathway  (EXP)
buprenorphine pharmacodynamics pathway  (EXP)
chloroprocaine pharmacodynamics pathway  (EXP)
citalopram pharmacodynamics pathway  (EXP)
cocaine pharmacodynamics pathway  (EXP)
codeine and morphine pharmacodynamics pathway  (EXP)
desipramine pharmacodynamics pathway  (EXP)
diphenoxylate pharmacodynamics pathway   (EXP)
dopamine signaling pathway  (ISO,TAS)
dopamine signaling pathway via D1 family of receptors  (EXP,TAS)
escitalopram pharmacodynamics pathway  (EXP)
ethylmorphine pharmacodynamics pathway  (EXP)
fentanyl pharmacodynamics pathway  (EXP)
fluoxetine pharmacodynamics pathway  (EXP)
G protein mediated signaling pathway via Galphaq family  (TAS)
G protein mediated signaling pathway via Galphas family  (TAS)
heroin pharmacodynamics pathway  (EXP)
hydrocodone pharmacodynamics pathway  (EXP)
hydromorphone pharmacodynamics pathway  (EXP)
imipramine pharmacodynamics pathway  (EXP)
levacetylmethadol pharmacodynamics pathway  (EXP)
levobupivacaine phgarmacodynamics pathway  (EXP)
levorphanol pharmacodynamics pathway  (EXP)
lidocaine pharmacodynamics pathway  (EXP)
mepivacaine pharmacodynamics pathway  (EXP)
methadone pharmacodynamics pathway  (EXP)
nalbuphine pharmacodynamics pathway  (EXP)
naloxone pharmacodynamics pathway  (EXP)
naltrexone pharmacodynamics pathway  (EXP)
nicotine pharmacodynamics pathway  (EXP)
oxybuprocaine pharmacodynamics pathway  (EXP)
oxycodone pharmacodynamics pathway  (EXP)
oxymorphone pharmacodynamics pathway  (EXP)
pentazocine pharmacodynamics pathway  (EXP)
prilocaine pharmacodynamics pathway  (EXP)
procaine pharmacodynamics pathway  (EXP)
remifentanil pharmacodynamics pathway  (EXP)
ropivacaine pharmacodynamics pathway  (EXP)
tramadol pharmacodynamics pathway  (EXP)

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Role of the D1A dopamine receptor in the pathogenesis of genetic hypertension. Albrecht FE, etal., J Clin Invest 1996 May 15;97(10):2283-8.
2. Striatal neurochemical changes in transgenic models of Huntington's disease. Ariano MA, etal., J Neurosci Res. 2002 Jun 15;68(6):716-29.
3. Acute sleep deprivation enhances avoidance learning and spatial memory and induces delayed alterations in neurochemical expression of GR, TH, DRD1, pCREB and Ki67 in rats. Azogu I, etal., Behav Brain Res. 2015 Feb 15;279:177-90. doi: 10.1016/j.bbr.2014.11.015. Epub 2014 Nov 26.
4. Tempol reduces oxidative stress, improves insulin sensitivity, decreases renal dopamine D1 receptor hyperphosphorylation, and restores D1 receptor-G-protein coupling and function in obese Zucker rats. Banday AA, etal., Diabetes. 2005 Jul;54(7):2219-26.
5. Mitogen-activated protein kinase upregulation reduces renal D1 receptor affinity and G-protein coupling in obese rats. Banday AA, etal., Kidney Int. 2007 Mar;71(5):397-406. Epub 2006 Dec 27.
6. The physiology, signaling, and pharmacology of dopamine receptors. Beaulieu JM and Gainetdinov RR, Pharmacol Rev. 2011 Mar;63(1):182-217. doi: 10.1124/pr.110.002642. Epub 2011 Feb 8.
7. Dopamine receptors - IUPHAR Review 13. Beaulieu JM, etal., Br J Pharmacol. 2015 Jan;172(1):1-23.
8. Tracheal occlusion modulates the gene expression profile of the medial thalamus in anesthetized rats. Bernhardt V, etal., J Appl Physiol. 2011 Jul;111(1):117-24. doi: 10.1152/japplphysiol.01317.2010. Epub 2011 Apr 28.
9. Isolated Flinders Sensitive Line rats have decreased dopamine D2 receptor mRNA. Bjornebekk A, etal., Neuroreport. 2007 Jul 2;18(10):1039-43.
10. Cognitive impairment and gene expression alterations in a rodent model of binge eating disorder. Chawla A, etal., Physiol Behav. 2017 Oct 15;180:78-90. doi: 10.1016/j.physbeh.2017.08.004. Epub 2017 Aug 15.
11. Dopamine receptor expression and distribution dynamically change in the rat nucleus accumbens after withdrawal from cocaine self-administration. Conrad KL, etal., Neuroscience. 2010 Aug 11;169(1):182-94. doi: 10.1016/j.neuroscience.2010.04.056. Epub 2010 May 7.
12. Aberrant cortical synaptic plasticity and dopaminergic dysfunction in a mouse model of Huntington's disease. Cummings DM, etal., Hum Mol Genet. 2006 Oct 1;15(19):2856-68. Epub 2006 Aug 11.
13. Loss of synaptic D1 dopamine/N-methyl-D-aspartate glutamate receptor complexes in L-DOPA-induced dyskinesia in the rat. Fiorentini C, etal., Mol Pharmacol. 2006 Mar;69(3):805-12. Epub 2005 Dec 19.
14. Dopaminergic regulation of inhibitory and excitatory transmission in the basolateral amygdala-prefrontal cortical pathway. Floresco SB and Tse MT, J Neurosci. 2007 Feb 21;27(8):2045-57.
15. Dopamine D1 receptor (DRD1) genetic polymorphism: pleiotropic effects on heritable renal traits. Fung MM, etal., Kidney Int. 2009 Nov;76(10):1070-80. doi: 10.1038/ki.2009.306. Epub 2009 Aug 12.
16. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
17. The neural correlates and role of D1 dopamine receptors in renewal of extinguished alcohol-seeking. Hamlin AS, etal., Neuroscience. 2007 May 11;146(2):525-36. doi: 10.1016/j.neuroscience.2007.01.063. Epub 2007 Mar 23.
18. Curcumin modulates dopaminergic receptor, CREB and phospholipase C gene expression in the cerebral cortex and cerebellum of streptozotocin induced diabetic rats. Kumar TP, etal., J Biomed Sci. 2010 May 31;17:43. doi: 10.1186/1423-0127-17-43.
19. Immunohistochemical localization of dopamine receptor subtypes (D1R-D5R) in Alzheimer's disease brain. Kumar U and Patel SC, Brain Res. 2007 Feb 2;1131(1):187-96. Epub 2006 Dec 19.
20. Dopamine D1/D5 receptors gate the acquisition of novel information through hippocampal long-term potentiation and long-term depression. Lemon N and Manahan-Vaughan D, J Neurosci. 2006 Jul 19;26(29):7723-9.
21. The usefulness of the spontaneously hypertensive rat to model attention-deficit/hyperactivity disorder (ADHD) may be explained by the differential expression of dopamine-related genes in the brain. Li Q, etal., Neurochem Int. 2007 May;50(6):848-57. Epub 2007 Mar 1.
22. Changes in Expression of Dopamine, Its Receptor, and Transporter in Nucleus Accumbens of Heroin-Addicted Rats with Brain-Derived Neurotrophic Factor (BDNF) Overexpression. Li Y, etal., Med Sci Monit. 2017 Jun 9;23:2805-2815.
23. Glycaemic control with insulin prevents the reduced renal dopamine D1 receptor expression and function in streptozotocin-induced diabetes. Moreira-Rodrigues M, etal., Nephrol Dial Transplant. 2010 Sep;25(9):2945-53. doi: 10.1093/ndt/gfq150. Epub 2010 Mar 25.
24. Expression of the dopaminergic D1 and D2 receptors in the anterior cingulate cortex in a model of neuropathic pain. Ortega-Legaspi JM, etal., Mol Pain. 2011 Dec 15;7:97.
25. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
26. PSD-95 expression controls L-DOPA dyskinesia through dopamine D1 receptor trafficking. Porras G, etal., J Clin Invest. 2012 Nov 1;122(11):3977-89. doi: 10.1172/JCI59426. Epub 2012 Oct 8.
27. Renal albumin excretion: twin studies identify influences of heredity, environment, and adrenergic pathway polymorphism. Rao F, etal., Hypertension. 2007 May;49(5):1015-31. Epub 2007 Mar 12.
28. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. Dysregulation of gene expression in primary neuron models of Huntington's disease shows that polyglutamine-related effects on the striatal transcriptome may not be dependent on brain circuitry. Runne H, etal., J Neurosci. 2008 Sep 24;28(39):9723-31.
31. Brain D1 dopamine receptor in alloxan-induced diabetes. Salkovic M and Lackovic Z, Diabetes. 1992 Sep;41(9):1119-21.
32. Ethanol concentration-dependent alterations in gene expression during acute binge drinking in the HIV-1 transgenic rat. Sarkar S and Chang SL, Alcohol Clin Exp Res. 2013 Jul;37(7):1082-90. doi: 10.1111/acer.12077. Epub 2013 Feb 15.
33. Dopamine D1 receptor gene polymorphism is associated with essential hypertension. Sato M, etal., Hypertension. 2000 Aug;36(2):183-6.
34. Electroacupuncture inhibition of hyperalgesia in rats with adjuvant arthritis: involvement of cannabinoid receptor 1 and dopamine receptor subtypes in striatum. Shou Y, etal., Evid Based Complement Alternat Med. 2013;2013:393460. doi: 10.1155/2013/393460. Epub 2013 May 25.
35. Blood pressure and renal sodium handling in relation to genetic variation in the DRD1 promoter and GRK4. Staessen JA, etal., Hypertension. 2008 Jun;51(6):1643-50. doi: 10.1161/HYPERTENSIONAHA.107.109611. Epub 2008 Apr 14.
36. Effect of UUO on D1aR expression reveals a link among dopamine, transforming growth factor-beta, and nitric oxide. Stern JM, etal., Am J Physiol Renal Physiol. 2004 Mar;286(3):F509-15. Epub 2003 Nov 11.
37. Amphetamine and environmentally induced hyperthermia differentially alter the expression of genes regulating vascular tone and angiogenesis in the meninges and associated vasculature. Thomas M, etal., Synapse. 2009 Oct;63(10):881-94.
38. Rosiglitazone restores renal D1A receptor-Gs protein coupling by reducing receptor hyperphosphorylation in obese rats. Trivedi M and Lokhandwala MF, Am J Physiol Renal Physiol. 2005 Aug;289(2):F298-304. Epub 2005 Mar 29.
39. Delivery of recombinant adeno-associated virus-mediated human tissue kallikrein for therapy of chronic renal failure in rats. Tu L, etal., Hum Gene Ther. 2008 Apr;19(4):318-30. doi: 10.1089/hum.2007.138.
40. Basal regulation of HPA and dopamine systems is altered differentially in males and females by prenatal alcohol exposure and chronic variable stress. Uban KA, etal., Psychoneuroendocrinology. 2013 Oct;38(10):1953-66. doi: 10.1016/j.psyneuen.2013.02.017. Epub 2013 Apr 8.
41. Dopamine D1 receptor mutant mice are deficient in striatal expression of dynorphin and in dopamine-mediated behavioral responses. Xu M, etal., Cell 1994 Nov 18;79(4):729-42.
42. Effects of enteral nutrition on the barrier function of the intestinal mucosa and dopamine receptor expression in rats with traumatic brain injury. Zhang X and Jiang X, JPEN J Parenter Enteral Nutr. 2015 Jan;39(1):114-23. doi: 10.1177/0148607113501881. Epub 2013 Sep 18.
Additional References at PubMed
PMID:1282671   PMID:1557411   PMID:1831904   PMID:1975640   PMID:1977312   PMID:2144334   PMID:2168520   PMID:7609904   PMID:7838121   PMID:8264547   PMID:8301582   PMID:8810292  
PMID:9457173   PMID:9920093   PMID:10051231   PMID:10618483   PMID:10692483   PMID:10890919   PMID:11140838   PMID:11331877   PMID:11500503   PMID:11583808   PMID:11723200   PMID:11773080  
PMID:11783439   PMID:11893085   PMID:11918350   PMID:11920160   PMID:12036966   PMID:12047334   PMID:12150791   PMID:12164861   PMID:12181426   PMID:12408866   PMID:12477932   PMID:12497608  
PMID:12509438   PMID:12509874   PMID:12646556   PMID:12738794   PMID:12781734   PMID:12966314   PMID:12967601   PMID:14569274   PMID:14993367   PMID:15159403   PMID:15192107   PMID:15247297  
PMID:15272078   PMID:15489334   PMID:15549138   PMID:15564897   PMID:15569306   PMID:15607627   PMID:15621009   PMID:15704231   PMID:15717291   PMID:15722953   PMID:15785860   PMID:15927089  
PMID:16338988   PMID:16344560   PMID:16391193   PMID:16397404   PMID:16424823   PMID:16594948   PMID:16816977   PMID:16846218   PMID:16876683   PMID:17066478   PMID:17092969   PMID:17194762  
PMID:17310237   PMID:17394052   PMID:17395585   PMID:17455212   PMID:17466946   PMID:17506933   PMID:17679637   PMID:17760784   PMID:18023044   PMID:18030347   PMID:18092181   PMID:18172057  
PMID:18197272   PMID:18205172   PMID:18210231   PMID:18237729   PMID:18240029   PMID:18270970   PMID:18341651   PMID:18366720   PMID:18380665   PMID:18382271   PMID:18403039   PMID:18403126  
PMID:18424554   PMID:18451638   PMID:18516948   PMID:18558372   PMID:18583979   PMID:18615540   PMID:18644790   PMID:18676680   PMID:18687376   PMID:18689859   PMID:18821566   PMID:18832011  
PMID:18855532   PMID:18937294   PMID:18937842   PMID:18946469   PMID:18984584   PMID:19000940   PMID:19005068   PMID:19058789   PMID:19086053   PMID:19105202   PMID:19143836   PMID:19153942  
PMID:19156168   PMID:19170196   PMID:19171671   PMID:19176223   PMID:19182156   PMID:19197069   PMID:19235789   PMID:19367581   PMID:19413572   PMID:19523047   PMID:19563515   PMID:19625176  
PMID:19647327   PMID:19692168   PMID:19695183   PMID:19772578   PMID:19786093   PMID:19864616   PMID:19874574   PMID:19897079   PMID:19913121   PMID:20071033   PMID:20081237   PMID:20127886  
PMID:20164562   PMID:20180564   PMID:20351714   PMID:20382433   PMID:20395553   PMID:20407490   PMID:20452395   PMID:20456319   PMID:20468064   PMID:20531939   PMID:20592018   PMID:20628086  
PMID:20672519   PMID:20677014   PMID:20685009   PMID:20714340   PMID:20732903   PMID:20734064   PMID:20807772   PMID:21041608   PMID:21083670   PMID:21115476   PMID:21178390   PMID:21181138  
PMID:21211326   PMID:21258043   PMID:21549202   PMID:21768159   PMID:21797797   PMID:21853233   PMID:21873635   PMID:21893192   PMID:21955727   PMID:21976513   PMID:22093926   PMID:22100647  
PMID:22206002   PMID:22277051   PMID:22310353   PMID:22336227   PMID:22404661   PMID:22408582   PMID:22495174   PMID:22552781   PMID:22574669   PMID:22699899   PMID:22710646   PMID:22764221  
PMID:22843680   PMID:23036699   PMID:23044706   PMID:23185343   PMID:23185434   PMID:23195037   PMID:23231809   PMID:23251661   PMID:23445730   PMID:23661099   PMID:23680635   PMID:23698121  
PMID:23842570   PMID:23908605   PMID:23952191   PMID:23976958   PMID:24001587   PMID:24004608   PMID:24078558   PMID:24135011   PMID:24136195   PMID:24167564   PMID:24292102   PMID:24322206  
PMID:24410560   PMID:24410775   PMID:24523562   PMID:24552847   PMID:24618367   PMID:24719111   PMID:24768614   PMID:25049074   PMID:25073922   PMID:25154512   PMID:25179995   PMID:25233244  
PMID:25268786   PMID:25281486   PMID:25527226   PMID:25613135   PMID:25660313   PMID:25740199   PMID:25825816   PMID:25896831   PMID:25966176   PMID:26041607   PMID:26186971   PMID:26337060  
PMID:26419600   PMID:26447226   PMID:26484506   PMID:26593092   PMID:26597879   PMID:26665568   PMID:26723139   PMID:26730182   PMID:26957229   PMID:27021648   PMID:27129257   PMID:27460146  
PMID:27472173   PMID:27497990   PMID:27570114   PMID:27591410   PMID:27620964   PMID:27701029   PMID:28119185   PMID:28154160   PMID:28361444   PMID:28416594   PMID:28579604   PMID:28582422  
PMID:28699280   PMID:28770955   PMID:28894300   PMID:29241537   PMID:29543812   PMID:29606146   PMID:29634738   PMID:29735686   PMID:29909784   PMID:30022436   PMID:30103286   PMID:30586202  
PMID:30626479   PMID:30958880   PMID:31119645   PMID:31123756   PMID:31131520   PMID:31192519   PMID:31858826   PMID:31962344   PMID:32052915   PMID:32484215   PMID:32761562   PMID:32770189  
PMID:32814053   PMID:32868781   PMID:32888283   PMID:33287325   PMID:33456556   PMID:33571431   PMID:33571432   PMID:33750903   PMID:34083522   PMID:34264865   PMID:34870351   PMID:35062349  
PMID:35396380   PMID:36441110   PMID:36649260   PMID:36894051   PMID:37024146   PMID:37252844   PMID:38302439  


Genomics

Comparative Map Data
DRD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385175,440,036 - 175,444,182 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5175,440,036 - 175,444,182 (-)EnsemblGRCh38hg38GRCh38
GRCh375174,867,039 - 174,871,185 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365174,800,281 - 174,803,769 (-)NCBINCBI36Build 36hg18NCBI36
Build 345174,800,642 - 174,803,769NCBI
Celera5170,906,676 - 170,910,164 (-)NCBICelera
Cytogenetic Map5q35.2NCBI
HuRef5169,967,086 - 169,970,574 (-)NCBIHuRef
CHM1_15174,300,099 - 174,303,587 (-)NCBICHM1_1
T2T-CHM13v2.05175,983,814 - 175,987,960 (-)NCBIT2T-CHM13v2.0
Drd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391354,205,202 - 54,209,677 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1354,205,202 - 54,209,724 (-)EnsemblGRCm39 Ensembl
GRCm381354,051,183 - 54,055,658 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1354,051,183 - 54,055,705 (-)EnsemblGRCm38mm10GRCm38
MGSCv371354,146,552 - 54,151,027 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361354,061,276 - 54,065,279 (-)NCBIMGSCv36mm8
Celera1355,124,170 - 55,128,645 (-)NCBICelera
Cytogenetic Map13B1NCBI
cM Map1328.4NCBI
Drd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81710,545,488 - 10,550,029 (+)NCBIGRCr8
mRatBN7.21710,540,440 - 10,544,971 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1710,540,558 - 10,545,002 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1710,555,287 - 10,558,713 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01712,089,485 - 12,092,911 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01710,551,719 - 10,555,145 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01711,099,736 - 11,104,352 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1711,101,306 - 11,103,541 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01713,211,031 - 13,215,581 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41716,655,926 - 16,658,161 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11716,655,119 - 16,658,949 (+)NCBI
Celera1710,610,221 - 10,613,646 (+)NCBICelera
Cytogenetic Map17p14NCBI
Drd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540828,003,229 - 28,006,595 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540828,003,229 - 28,006,595 (-)NCBIChiLan1.0ChiLan1.0
DRD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24170,570,821 - 170,577,577 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15168,710,364 - 168,717,128 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05170,787,115 - 170,792,383 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15177,687,201 - 177,691,376 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5177,688,917 - 177,690,257 (-)Ensemblpanpan1.1panPan2
DRD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1437,550,454 - 37,554,641 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl437,549,708 - 37,553,287 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha437,496,619 - 37,501,286 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0437,916,432 - 37,921,101 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl437,916,400 - 37,921,094 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1437,741,033 - 37,745,149 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0437,928,336 - 37,933,009 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0438,438,479 - 38,443,142 (+)NCBIUU_Cfam_GSD_1.0
Drd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721392,067,956 - 92,072,508 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936609792,276 - 793,613 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936609790,647 - 795,187 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DRD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1649,189,602 - 49,191,976 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11649,189,555 - 49,193,722 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21653,333,853 - 53,338,671 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DRD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12377,587,340 - 77,591,434 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666034997,268 - 1,002,449 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Drd1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473314,518,146 - 14,520,905 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473314,517,540 - 14,522,173 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in DRD1
15 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 5q32-35.3(chr5:149714592-181272151)x3 copy number gain See cases [RCV000051863] Chr5:149714592..181272151 [GRCh38]
Chr5:149094155..180699152 [GRCh37]
Chr5:149074348..180631758 [NCBI36]
Chr5:5q32-35.3		 pathogenic
GRCh38/hg38 5q33.3-35.3(chr5:160029980-181269805)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051865]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051865]|See cases [RCV000051865] Chr5:160029980..181269805 [GRCh38]
Chr5:159456987..180696806 [GRCh37]
Chr5:159389565..180629412 [NCBI36]
Chr5:5q33.3-35.3		 pathogenic
GRCh38/hg38 5q34-35.3(chr5:168689326-181269946)x3 copy number gain See cases [RCV000051866] Chr5:168689326..181269946 [GRCh38]
Chr5:168116331..180696947 [GRCh37]
Chr5:168048909..180629553 [NCBI36]
Chr5:5q34-35.3		 pathogenic
GRCh38/hg38 5q35.2-35.3(chr5:175007241-179089812)x1 copy number loss See cases [RCV000052151] Chr5:175007241..179089812 [GRCh38]
Chr5:174434244..178516813 [GRCh37]
Chr5:174366850..178449419 [NCBI36]
Chr5:5q35.2-35.3		 pathogenic
NM_000794.3(DRD1):c.564C>T (p.Ser188=) single nucleotide variant Malignant melanoma [RCV000061216] Chr5:175442536 [GRCh38]
Chr5:174869539 [GRCh37]
Chr5:174802145 [NCBI36]
Chr5:5q35.2		 not provided
GRCh38/hg38 5q33.3-35.3(chr5:156825512-181269805)x3 copy number gain See cases [RCV000133847] Chr5:156825512..181269805 [GRCh38]
Chr5:156252523..180696806 [GRCh37]
Chr5:156185101..180629412 [NCBI36]
Chr5:5q33.3-35.3		 pathogenic
GRCh38/hg38 5q34-35.3(chr5:164386701-181269805)x3 copy number gain See cases [RCV000135546] Chr5:164386701..181269805 [GRCh38]
Chr5:163813707..180696806 [GRCh37]
Chr5:163746285..180629412 [NCBI36]
Chr5:5q34-35.3		 pathogenic
GRCh38/hg38 5q35.1-35.3(chr5:169334755-181285301)x3 copy number gain See cases [RCV000141249] Chr5:169334755..181285301 [GRCh38]
Chr5:168761759..180712302 [GRCh37]
Chr5:168694337..180644908 [NCBI36]
Chr5:5q35.1-35.3		 pathogenic
GRCh38/hg38 5q35.1-35.2(chr5:173237772-176614618)x3 copy number gain See cases [RCV000142647] Chr5:173237772..176614618 [GRCh38]
Chr5:172664775..176041619 [GRCh37]
Chr5:172597381..175974225 [NCBI36]
Chr5:5q35.1-35.2		 pathogenic
GRCh37/hg19 5q35.2-35.3(chr5:174397487-180686444)x1 copy number loss See cases [RCV000167565] Chr5:174397487..180686444 [GRCh37]
Chr5:5q35.2-35.3		 pathogenic
GRCh37/hg19 5q35.2(chr5:173043321-174953690)x3 copy number gain Breast ductal adenocarcinoma [RCV000207114] Chr5:173043321..174953690 [GRCh37]
Chr5:5q35.2		 uncertain significance
GRCh37/hg19 5q15-35.3(chr5:94844077-178830410)x3 copy number gain not provided [RCV000487658] Chr5:94844077..178830410 [GRCh37]
Chr5:5q15-35.3		 likely benign
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789) copy number gain See cases [RCV000510723] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3		 pathogenic
GRCh37/hg19 5q35.2-35.3(chr5:174427052-180719789)x1 copy number loss See cases [RCV000448611] Chr5:174427052..180719789 [GRCh37]
Chr5:5q35.2-35.3		 pathogenic
GRCh37/hg19 5q21.3-35.3(chr5:106716357-180687338)x3 copy number gain See cases [RCV000448245] Chr5:106716357..180687338 [GRCh37]
Chr5:5q21.3-35.3		 pathogenic
GRCh37/hg19 5q35.1-35.3(chr5:171396359-180719789)x3 copy number gain See cases [RCV000448458] Chr5:171396359..180719789 [GRCh37]
Chr5:5q35.1-35.3		 pathogenic
GRCh37/hg19 5q35.1-35.3(chr5:172031248-180719789)x3 copy number gain See cases [RCV000512068] Chr5:172031248..180719789 [GRCh37]
Chr5:5q35.1-35.3		 pathogenic
GRCh37/hg19 5p15.1-q35.2(chr5:17628741-176575720)x1 copy number loss See cases [RCV000511978] Chr5:17628741..176575720 [GRCh37]
Chr5:5p15.1-q35.2		 pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789)x3 copy number gain See cases [RCV000512039] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3		 pathogenic
NM_000794.5(DRD1):c.-48G>A single nucleotide variant not specified [RCV000608357] Chr5:175443147 [GRCh38]
Chr5:174870150 [GRCh37]
Chr5:5q35.2		 likely benign
NM_000794.5(DRD1):c.-48= single nucleotide variant not specified [RCV000601952] Chr5:175443147 [GRCh38]
Chr5:174870150 [GRCh37]
Chr5:5q35.2		 benign
GRCh37/hg19 5p15.33-q35.3(chr5:25328-180693344)x3 copy number gain not provided [RCV000744323] Chr5:25328..180693344 [GRCh37]
Chr5:5p15.33-q35.3		 pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:13648-180905029)x3 copy number gain not provided [RCV000744317] Chr5:13648..180905029 [GRCh37]
Chr5:5p15.33-q35.3		 pathogenic
GRCh37/hg19 5q33.2-35.3(chr5:155344802-180693344)x3 copy number gain not provided [RCV000745284] Chr5:155344802..180693344 [GRCh37]
Chr5:5q33.2-35.3		 pathogenic
GRCh37/hg19 5q35.2-35.3(chr5:174832617-180693344)x3 copy number gain not provided [RCV000745336] Chr5:174832617..180693344 [GRCh37]
Chr5:5q35.2-35.3		 pathogenic
NM_000794.5(DRD1):c.522A>C (p.Gly174=) single nucleotide variant not provided [RCV000927435] Chr5:175442578 [GRCh38]
Chr5:174869581 [GRCh37]
Chr5:5q35.2		 likely benign
NM_000794.5(DRD1):c.1317A>G (p.Thr439=) single nucleotide variant not provided [RCV000900947] Chr5:175441783 [GRCh38]
Chr5:174868786 [GRCh37]
Chr5:5q35.2		 likely benign
NM_000794.5(DRD1):c.1044C>T (p.Tyr348=) single nucleotide variant not provided [RCV000896636] Chr5:175442056 [GRCh38]
Chr5:174869059 [GRCh37]
Chr5:5q35.2		 benign
NM_000794.5(DRD1):c.432C>T (p.Ile144=) single nucleotide variant not provided [RCV000909511] Chr5:175442668 [GRCh38]
Chr5:174869671 [GRCh37]
Chr5:5q35.2		 benign
GRCh37/hg19 5q32-35.3(chr5:149010383-180719789) copy number gain Hunter-McAlpine craniosynostosis [RCV002280612] Chr5:149010383..180719789 [GRCh37]
Chr5:5q32-35.3		 pathogenic
GRCh37/hg19 5q35.1-35.3(chr5:170805664-180719789)x3 copy number gain 5q35 microduplication syndrome [RCV001263227] Chr5:170805664..180719789 [GRCh37]
Chr5:5q35.1-35.3		 pathogenic
GRCh37/hg19 5q35.1-35.3(chr5:170350336-180719789)x3 copy number gain See cases [RCV002292398] Chr5:170350336..180719789 [GRCh37]
Chr5:5q35.1-35.3		 pathogenic
NM_000794.5(DRD1):c.223G>A (p.Val75Ile) single nucleotide variant Inborn genetic diseases [RCV003012711] Chr5:175442877 [GRCh38]
Chr5:174869880 [GRCh37]
Chr5:5q35.2		 uncertain significance
NM_000794.5(DRD1):c.50A>T (p.Glu17Val) single nucleotide variant Inborn genetic diseases [RCV002902464] Chr5:175443050 [GRCh38]
Chr5:174870053 [GRCh37]
Chr5:5q35.2		 uncertain significance
NM_000794.5(DRD1):c.1336A>G (p.Thr446Ala) single nucleotide variant Inborn genetic diseases [RCV002926052] Chr5:175441764 [GRCh38]
Chr5:174868767 [GRCh37]
Chr5:5q35.2		 uncertain significance
NM_000794.5(DRD1):c.544A>G (p.Thr182Ala) single nucleotide variant Inborn genetic diseases [RCV002980186] Chr5:175442556 [GRCh38]
Chr5:174869559 [GRCh37]
Chr5:5q35.2		 uncertain significance
NM_000794.5(DRD1):c.469A>G (p.Ile157Val) single nucleotide variant Inborn genetic diseases [RCV002854626] Chr5:175442631 [GRCh38]
Chr5:174869634 [GRCh37]
Chr5:5q35.2		 uncertain significance
NM_000794.5(DRD1):c.43G>A (p.Val15Met) single nucleotide variant Inborn genetic diseases [RCV002665754] Chr5:175443057 [GRCh38]
Chr5:174870060 [GRCh37]
Chr5:5q35.2		 uncertain significance
NM_000794.5(DRD1):c.1040G>A (p.Cys347Tyr) single nucleotide variant Inborn genetic diseases [RCV002929337] Chr5:175442060 [GRCh38]
Chr5:174869063 [GRCh37]
Chr5:5q35.2		 uncertain significance
NM_000794.5(DRD1):c.1187G>T (p.Gly396Val) single nucleotide variant Inborn genetic diseases [RCV003261183] Chr5:175441913 [GRCh38]
Chr5:174868916 [GRCh37]
Chr5:5q35.2		 uncertain significance
GRCh37/hg19 5q35.1-35.2(chr5:171836503-176517734)x1 copy number loss not provided [RCV003485492] Chr5:171836503..176517734 [GRCh37]
Chr5:5q35.1-35.2		 pathogenic
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR504hsa-miR-504-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI19135651

Predicted Target Of
Summary Value
Count of predictions:469
Count of miRNA genes:366
Interacting mature miRNAs:380
Transcripts:ENST00000393752
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
G44335  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375174,868,701 - 174,868,852UniSTSGRCh37
Build 365174,801,307 - 174,801,458RGDNCBI36
Celera5170,907,702 - 170,907,853RGD
Cytogenetic Map5q35.1UniSTS
HuRef5169,968,112 - 169,968,263UniSTS
GDB:210842  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375174,868,741 - 174,869,060UniSTSGRCh37
Build 365174,801,347 - 174,801,666RGDNCBI36
Celera5170,907,742 - 170,908,061RGD
Cytogenetic Map5q35.1UniSTS
HuRef5169,968,152 - 169,968,471UniSTS
GDB:251589  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375174,870,152 - 174,870,376UniSTSGRCh37
Build 365174,802,758 - 174,802,982RGDNCBI36
Celera5170,909,153 - 170,909,377RGD
Cytogenetic Map5q35.1UniSTS
HuRef5169,969,563 - 169,969,787UniSTS
GDB:251590  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375174,869,965 - 174,870,171UniSTSGRCh37
Build 365174,802,571 - 174,802,777RGDNCBI36
Celera5170,908,966 - 170,909,172RGD
Cytogenetic Map5q35.1UniSTS
HuRef5169,969,376 - 169,969,582UniSTS
GDB:251591  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375174,868,698 - 174,868,859UniSTSGRCh37
Build 365174,801,304 - 174,801,465RGDNCBI36
Celera5170,907,699 - 170,907,860RGD
Cytogenetic Map5q35.1UniSTS
HuRef5169,968,109 - 169,968,270UniSTS
GDB:251592  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375174,868,677 - 174,868,865UniSTSGRCh37
Build 365174,801,283 - 174,801,471RGDNCBI36
Celera5170,907,678 - 170,907,866RGD
Cytogenetic Map5q35.1UniSTS
HuRef5169,968,088 - 169,968,276UniSTS
GDB:595086  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375174,868,737 - 174,870,154UniSTSGRCh37
Build 365174,801,343 - 174,802,760RGDNCBI36
Celera5170,907,738 - 170,909,155RGD
Cytogenetic Map5q35.1UniSTS
HuRef5169,968,148 - 169,969,565UniSTS
GDB:595113  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375174,869,340 - 174,870,354UniSTSGRCh37
Build 365174,801,946 - 174,802,960RGDNCBI36
Celera5170,908,341 - 170,909,355RGD
Cytogenetic Map5q35.1UniSTS
HuRef5169,968,751 - 169,969,765UniSTS
GDB:595139  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375174,868,849 - 174,869,563UniSTSGRCh37
Build 365174,801,455 - 174,802,169RGDNCBI36
Celera5170,907,850 - 170,908,564RGD
Cytogenetic Map5q35.1UniSTS
HuRef5169,968,260 - 169,968,974UniSTS
GDB:595147  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375174,868,448 - 174,869,191UniSTSGRCh37
GRCh37486,051,663 - 86,053,338UniSTSGRCh37
Build 365174,801,054 - 174,801,797RGDNCBI36
Celera483,342,270 - 83,343,945UniSTS
Celera5170,907,449 - 170,908,192RGD
Cytogenetic Map5q35.1UniSTS
HuRef5169,967,859 - 169,968,602UniSTS
HuRef481,793,927 - 81,795,602UniSTS
GDB:681987  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375174,867,510 - 174,867,981UniSTSGRCh37
Build 365174,800,116 - 174,800,587RGDNCBI36
Celera5170,906,511 - 170,906,982RGD
Cytogenetic Map5q35.1UniSTS
HuRef5169,966,921 - 169,967,392UniSTS
PMC311033P2  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375174,870,019 - 174,870,168UniSTSGRCh37
Build 365174,802,625 - 174,802,774RGDNCBI36
Celera5170,909,020 - 170,909,169RGD
Cytogenetic Map5q35.1UniSTS
HuRef5169,969,430 - 169,969,579UniSTS
DRD1_599  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375174,867,983 - 174,868,837UniSTSGRCh37
Build 365174,800,589 - 174,801,443RGDNCBI36
Celera5170,906,984 - 170,907,838RGD
HuRef5169,967,394 - 169,968,248UniSTS
SGC34944  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375174,867,315 - 174,867,464UniSTSGRCh37
Build 365174,799,921 - 174,800,070RGDNCBI36
Celera5170,906,316 - 170,906,465RGD
Cytogenetic Map5q35.1UniSTS
HuRef5169,966,726 - 169,966,875UniSTS
GeneMap99-GB4 RH Map5642.9UniSTS
Whitehead-RH Map5539.8UniSTS
DRD1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375174,868,393 - 174,868,576UniSTSGRCh37
Build 365174,800,999 - 174,801,182RGDNCBI36
Celera5170,907,394 - 170,907,577RGD
HuRef5169,967,804 - 169,967,987UniSTS
RH16255  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375174,867,263 - 174,867,413UniSTSGRCh37
Build 365174,799,869 - 174,800,019RGDNCBI36
Celera5170,906,264 - 170,906,414RGD
Cytogenetic Map5q35.1UniSTS
HuRef5169,966,674 - 169,966,824UniSTS
GeneMap99-GB4 RH Map5642.9UniSTS
RH18117  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375174,868,357 - 174,868,489UniSTSGRCh37
Build 365174,800,963 - 174,801,095RGDNCBI36
Celera5170,907,358 - 170,907,490RGD
Cytogenetic Map5q35.1UniSTS
HuRef5169,967,768 - 169,967,900UniSTS
GeneMap99-GB4 RH Map5636.91UniSTS
D5S2403  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375174,868,322 - 174,868,647UniSTSGRCh37
Build 365174,800,928 - 174,801,253RGDNCBI36
Celera5170,907,323 - 170,907,648RGD
Cytogenetic Map5q35.1UniSTS
HuRef5169,967,733 - 169,968,058UniSTS
Whitehead-YAC Contig Map5 UniSTS
UniSTS:482142  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375174,868,720 - 174,870,378UniSTSGRCh37
Celera5170,907,721 - 170,909,379UniSTS
HuRef5169,968,131 - 169,969,789UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
High
Medium 2 3 3 2 2 2 549 6 1 12
Low 458 651 476 162 98 160 919 126 1882 90 501 652 9 1 560 628 1
Below cutoff 1846 1458 1135 391 660 241 3018 1642 1240 209 756 768 154 638 1923 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_011802 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_000794 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB065677 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC091393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF498961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK314031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC074978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC074979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC096837 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR541922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA249160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M85247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S58541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X55758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X55760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X58987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000393752   ⟹   ENSP00000377353
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5175,440,036 - 175,444,182 (-)Ensembl
RefSeq Acc Id: NM_000794   ⟹   NP_000785
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385175,440,036 - 175,444,182 (-)NCBI
GRCh375174,867,675 - 174,871,163 (-)ENTREZGENE
Build 365174,800,281 - 174,803,769 (-)NCBI Archive
HuRef5169,967,086 - 169,970,574 (-)ENTREZGENE
CHM1_15174,300,099 - 174,303,587 (-)NCBI
T2T-CHM13v2.05175,983,814 - 175,987,960 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_000785   ⟸   NM_000794
- UniProtKB: B2RA44 (UniProtKB/Swiss-Prot),   Q4QRJ0 (UniProtKB/Swiss-Prot),   P21728 (UniProtKB/Swiss-Prot),   Q6FH34 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000377353   ⟸   ENST00000393752
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P21728-F1-model_v2 AlphaFold P21728 1-446 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:3020 AgrOrtholog
COSMIC DRD1 COSMIC
Ensembl Genes ENSG00000184845 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000393752 ENTREZGENE
  ENST00000393752.3 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000184845 GTEx
HGNC ID HGNC:3020 ENTREZGENE
Human Proteome Map DRD1 Human Proteome Map
InterPro Dopamine_D1_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dopamine_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:1812 UniProtKB/Swiss-Prot
NCBI Gene 1812 ENTREZGENE
OMIM 126449 OMIM
PANTHER ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  D(1A) DOPAMINE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB DRD1 RGD, PharmGKB
PRINTS DOPAMINED1AR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DOPAMINER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B2RA44 ENTREZGENE
  DRD1_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q4QRJ0 ENTREZGENE
  Q6FH34 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary B2RA44 UniProtKB/Swiss-Prot
  Q4QRJ0 UniProtKB/Swiss-Prot