FCER1G (Fc epsilon receptor Ig) - Rat Genome Database

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Pathways
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Gene: FCER1G (Fc epsilon receptor Ig) Homo sapiens
Analyze
Symbol: FCER1G
Name: Fc epsilon receptor Ig
RGD ID: 736226
HGNC Page HGNC:3611
Description: Enables protein homodimerization activity. Involved in Fc-epsilon receptor signaling pathway. Located in cell surface and plasma membrane. Part of Fc-gamma receptor III complex.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: Fc fragment of IgE receptor Ig; Fc fragment of IgE, high affinity I, receptor for; Fc receptor gamma-chain; fc receptor, ige, high affinity i, gamma polypeptide; fc-epsilon RI-gamma; FcepsilonRI gamma chain; FcepsilonRIgamma; fceRI gamma; FCRG; fcRgamma; gamma polypeptide; high affinity immunoglobulin epsilon receptor subunit gamma; igE Fc receptor subunit gamma; immunoglobulin E receptor, high affinity, gamma chain
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381161,215,295 - 161,219,245 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1161,215,234 - 161,220,699 (+)EnsemblGRCh38hg38GRCh38
GRCh371161,185,085 - 161,189,035 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361159,451,711 - 159,455,662 (+)NCBINCBI36Build 36hg18NCBI36
Build 341157,998,159 - 158,002,111NCBI
Celera1134,252,239 - 134,256,190 (+)NCBICelera
Cytogenetic Map1q23.3NCBI
HuRef1132,542,035 - 132,545,988 (+)NCBIHuRef
CHM1_11162,581,340 - 162,585,295 (+)NCBICHM1_1
T2T-CHM13v2.01160,352,747 - 160,356,700 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,5-hexanedione  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (EXP)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acetylsalicylic acid  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP)
amitrole  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
antirheumatic drug  (EXP)
aristolochic acid A  (EXP)
arsenous acid  (EXP)
beclomethasone  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
calcitriol  (EXP)
carbon nanotube  (ISO)
chlordecone  (ISO)
choline  (ISO)
cisplatin  (ISO)
citalopram  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
Cuprizon  (ISO)
cyclophosphamide  (ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP)
diclofenac  (ISO)
diethylstilbestrol  (ISO)
diquat  (ISO)
diuron  (ISO)
fenbuconazole  (EXP)
folic acid  (ISO)
fulvestrant  (EXP)
ginkgolide B  (ISO)
glucose  (ISO)
ketotifen  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (EXP,ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methimazole  (ISO)
methotrexate  (EXP)
methylmercury chloride  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
nickel atom  (EXP)
nilotinib  (EXP)
ochratoxin A  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
probucol  (ISO)
quercetin  (EXP)
resveratrol  (ISO)
serpentine asbestos  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (EXP)
sodium dichromate  (ISO)
streptozocin  (ISO)
tamibarotene  (EXP)
testosterone  (ISO)
testosterone enanthate  (EXP)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
valproic acid  (EXP)
vinclozolin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
antigen processing and presentation of exogenous peptide antigen via MHC class I  (IBA,IEA,ISO)
antigen processing and presentation of exogenous peptide antigen via MHC class II  (IBA,IEA,ISO)
cell surface receptor signaling pathway  (IEA,ISO)
cellular response to low-density lipoprotein particle stimulus  (ISS)
defense response to bacterium  (IBA,IEA,ISO)
Fc receptor mediated stimulatory signaling pathway  (IBA,IEA,ISO)
Fc-epsilon receptor signaling pathway  (IEA,IMP)
Fc-gamma receptor signaling pathway  (IBA,IEA,ISO)
immune system process  (IEA)
immunoglobulin mediated immune response  (IBA,IEA,ISO)
innate immune response  (IBA,IEA,ISO)
integrin-mediated signaling pathway  (ISO)
interleukin-3-mediated signaling pathway  (ISS)
mast cell activation  (ISO)
mast cell apoptotic process  (ISO)
mast cell degranulation  (ISO)
negative regulation of mast cell apoptotic process  (ISO)
neutrophil activation involved in immune response  (IBA,IEA)
neutrophil chemotaxis  (IBA,IEA,ISO)
osteoclast differentiation  (ISO)
phagocytosis, engulfment  (ISO)
positive regulation of immune response  (ISO)
positive regulation of interleukin-10 production  (ISO)
positive regulation of interleukin-4 production  (ISS)
positive regulation of interleukin-6 production  (ISO)
positive regulation of mast cell cytokine production  (ISO)
positive regulation of mast cell degranulation  (ISO)
positive regulation of phagocytosis  (IBA,IEA,ISO)
positive regulation of protein localization to cell surface  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of type I hypersensitivity  (ISO)
positive regulation of type IIa hypersensitivity  (ISO)
positive regulation of type III hypersensitivity  (ISO)
protein localization to plasma membrane  (ISO)
receptor internalization  (ISS)
regulation of immune response  (ISO)
regulation of platelet activation  (IBA,IEA)
serotonin secretion by platelet  (ISO)
signal transduction  (ISO)
T cell differentiation involved in immune response  (IBA,IEA,ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
3. Association of three sets of high-affinity IgE receptor (FcepsilonR1) polymorphisms with aspirin-intolerant asthma. Palikhe NS, etal., Respir Med. 2008 Aug;102(8):1132-9. doi: 10.1016/j.rmed.2008.03.017. Epub 2008 Jul 1.
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1535625   PMID:2138619   PMID:2146219   PMID:8071371   PMID:8752908   PMID:8810294   PMID:9028946   PMID:9280292   PMID:9295288   PMID:10049942   PMID:10194433   PMID:10469124  
PMID:10825177   PMID:10942756   PMID:11388899   PMID:11788586   PMID:11898918   PMID:11943772   PMID:11980568   PMID:12366784   PMID:12477932   PMID:12594225   PMID:12626537   PMID:12836193  
PMID:14967045   PMID:15096494   PMID:15778339   PMID:16710414   PMID:16735691   PMID:17192395   PMID:17430357   PMID:17850179   PMID:18292514   PMID:18378679   PMID:18402654   PMID:18534082  
PMID:19362683   PMID:19423540   PMID:19913121   PMID:20028371   PMID:20126404   PMID:20237496   PMID:20406964   PMID:20438785   PMID:20628086   PMID:20959446   PMID:21873635   PMID:22150093  
PMID:22291008   PMID:22401598   PMID:22664044   PMID:22706086   PMID:23228155   PMID:23874603   PMID:24023253   PMID:24623722   PMID:25513989   PMID:26311901   PMID:27365531   PMID:27630214  
PMID:28652325   PMID:29143175   PMID:29209141   PMID:31867015   PMID:32296183   PMID:32513696   PMID:32812023   PMID:33786672   PMID:34115526   PMID:34362877   PMID:35078433   PMID:36054819  
PMID:36066491   PMID:36217030   PMID:37170758   PMID:37821074  


Genomics

Comparative Map Data
FCER1G
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381161,215,295 - 161,219,245 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1161,215,234 - 161,220,699 (+)EnsemblGRCh38hg38GRCh38
GRCh371161,185,085 - 161,189,035 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361159,451,711 - 159,455,662 (+)NCBINCBI36Build 36hg18NCBI36
Build 341157,998,159 - 158,002,111NCBI
Celera1134,252,239 - 134,256,190 (+)NCBICelera
Cytogenetic Map1q23.3NCBI
HuRef1132,542,035 - 132,545,988 (+)NCBIHuRef
CHM1_11162,581,340 - 162,585,295 (+)NCBICHM1_1
T2T-CHM13v2.01160,352,747 - 160,356,700 (+)NCBIT2T-CHM13v2.0
Fcer1g
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391171,057,141 - 171,061,918 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1171,057,141 - 171,061,934 (-)EnsemblGRCm39 Ensembl
GRCm381171,229,572 - 171,234,349 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1171,229,572 - 171,234,365 (-)EnsemblGRCm38mm10GRCm38
MGSCv371173,159,703 - 173,164,480 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361173,066,247 - 173,071,024 (-)NCBIMGSCv36mm8
Celera1173,677,711 - 173,690,567 (-)NCBICelera
Cytogenetic Map1H3NCBI
cM Map179.23NCBI
Fcer1g
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81386,181,908 - 86,186,766 (-)NCBIGRCr8
mRatBN7.21383,649,447 - 83,654,248 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1383,649,449 - 83,671,443 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1386,155,292 - 86,160,092 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01387,553,532 - 87,558,332 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01384,785,150 - 84,789,956 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01389,601,894 - 89,606,326 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1389,601,896 - 89,606,326 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01394,228,759 - 94,233,459 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41387,119,464 - 87,123,902 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11387,308,348 - 87,312,727 (-)NCBI
Celera1383,280,630 - 83,285,062 (-)NCBICelera
Cytogenetic Map13q24NCBI
Fcer1g
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546812,971,931 - 12,975,206 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546812,971,931 - 12,975,206 (+)NCBIChiLan1.0ChiLan1.0
FCER1G
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2188,632,756 - 88,636,775 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1188,323,067 - 88,327,094 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01136,627,672 - 136,631,696 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11140,539,555 - 140,543,545 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1140,539,555 - 140,544,810 (+)Ensemblpanpan1.1panPan2
FCER1G
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13821,267,841 - 21,271,036 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3821,268,001 - 21,270,940 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3821,342,857 - 21,345,796 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03821,385,844 - 21,388,784 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3821,385,844 - 21,388,784 (-)EnsemblROS_Cfam_1.0 Ensembl
UNSW_CanFamBas_1.03821,688,132 - 21,691,072 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03822,097,280 - 22,100,221 (-)NCBIUU_Cfam_GSD_1.0
Fcer1g
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050587,305,613 - 7,309,317 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936903514,761 - 517,948 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936903514,278 - 517,975 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FCER1G
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl489,242,472 - 89,246,450 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1489,242,467 - 89,246,344 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2497,099,149 - 97,103,026 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FCER1G
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1202,763,412 - 2,767,774 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl202,763,417 - 2,767,248 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660381,811,779 - 1,815,687 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fcer1g
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624794168,564 - 172,034 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624794168,564 - 172,433 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in FCER1G
6 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1q23.3(chr1:160866658-161315114)x3 copy number gain See cases [RCV000051555] Chr1:160866658..161315114 [GRCh38]
Chr1:160836448..161284904 [GRCh37]
Chr1:159103072..159551528 [NCBI36]
Chr1:1q23.3		 uncertain significance
GRCh38/hg38 1q23.2-24.1(chr1:159479887-166895086)x1 copy number loss See cases [RCV000051172] Chr1:159479887..166895086 [GRCh38]
Chr1:159449677..166864323 [GRCh37]
Chr1:157716301..165130947 [NCBI36]
Chr1:1q23.2-24.1		 pathogenic
GRCh38/hg38 1q23.1-25.1(chr1:157747246-176021247)x3 copy number gain See cases [RCV000051854] Chr1:157747246..176021247 [GRCh38]
Chr1:157717036..175990383 [GRCh37]
Chr1:155983660..174257006 [NCBI36]
Chr1:1q23.1-25.1		 pathogenic
GRCh38/hg38 1q23.3-24.2(chr1:160789732-168617494)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053913]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053913]|See cases [RCV000053913] Chr1:160789732..168617494 [GRCh38]
Chr1:160759522..168586732 [GRCh37]
Chr1:159026146..166853356 [NCBI36]
Chr1:1q23.3-24.2		 pathogenic
NM_001643.1(APOA2):c.30C>T (p.Leu10=) single nucleotide variant Malignant melanoma [RCV000059965] Chr1:161223372 [GRCh38]
Chr1:161193162 [GRCh37]
Chr1:159459786 [NCBI36]
Chr1:1q23.3		 not provided
NM_004550.4(NDUFS2):c.1032C>T (p.Ile344=) single nucleotide variant Malignant melanoma [RCV000059964] Chr1:161212396 [GRCh38]
Chr1:161182186 [GRCh37]
Chr1:159448810 [NCBI36]
Chr1:1q23.3		 not provided
GRCh38/hg38 1q21.2-25.2(chr1:149854269-180267197)x3 copy number gain See cases [RCV000143515] Chr1:149854269..180267197 [GRCh38]
Chr1:149825831..180236332 [GRCh37]
Chr1:148092455..178502955 [NCBI36]
Chr1:1q21.2-25.2		 pathogenic
GRCh37/hg19 1q23.2-25.1(chr1:160369890-175796325) copy number loss not provided [RCV000767779] Chr1:160369890..175796325 [GRCh37]
Chr1:1q23.2-25.1		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1q23.2-25.2(chr1:159815642-177026983)x1 copy number loss not provided [RCV000736717] Chr1:159815642..177026983 [GRCh37]
Chr1:1q23.2-25.2		 pathogenic
NC_000001.10:g.(?_160786670)_(161332233_?)dup duplication Gastrointestinal stromal tumor [RCV000792787] Chr1:160816880..161362443 [GRCh38]
Chr1:160786670..161332233 [GRCh37]
Chr1:1q23.3		 uncertain significance
NC_000001.11:g.(?_160816880)_(161362518_?)dup duplication Gastrointestinal stromal tumor [RCV001031279] Chr1:160786670..161332308 [GRCh37]
Chr1:1q23.3		 uncertain significance
GRCh37/hg19 1q23.3(chr1:160977795-161189147)x3 copy number gain not provided [RCV001005145] Chr1:160977795..161189147 [GRCh37]
Chr1:1q23.3		 uncertain significance
GRCh37/hg19 1q23.3(chr1:160744174-162583871)x3 copy number gain not provided [RCV000849025] Chr1:160744174..162583871 [GRCh37]
Chr1:1q23.3		 uncertain significance
GRCh37/hg19 1q23.3(chr1:161134612-161422225)x3 copy number gain not provided [RCV000848107] Chr1:161134612..161422225 [GRCh37]
Chr1:1q23.3		 uncertain significance
GRCh37/hg19 1q23.3(chr1:161134675-161652307)x3 copy number gain not provided [RCV001005146] Chr1:161134675..161652307 [GRCh37]
Chr1:1q23.3		 uncertain significance
GRCh37/hg19 1q23.1-24.2(chr1:157321299-167391423)x1 copy number loss not provided [RCV000848773] Chr1:157321299..167391423 [GRCh37]
Chr1:1q23.1-24.2		 pathogenic
NC_000001.10:g.(?_130980840)_(248900000_?)dup duplication Gastrointestinal stromal tumor [RCV001300221]|Parathyroid carcinoma [RCV001341077] Chr1:130980840..248900000 [GRCh37]
Chr1:1q12-44		 uncertain significance
GRCh37/hg19 1q23.2-24.1(chr1:160417296-166197042) copy number loss not specified [RCV002053658] Chr1:160417296..166197042 [GRCh37]
Chr1:1q23.2-24.1		 pathogenic
GRCh37/hg19 1q23.3(chr1:160859558-161409185)x3 copy number gain not provided [RCV001829131] Chr1:160859558..161409185 [GRCh37]
Chr1:1q23.3		 likely pathogenic
NC_000001.10:g.(?_158581054)_(162750036_?)dup duplication Autoimmune interstitial lung disease-arthritis syndrome [RCV001918952]|not provided [RCV001918953] Chr1:158581054..162750036 [GRCh37]
Chr1:1q23.1-23.3		 uncertain significance|no classifications from unflagged records
NC_000001.10:g.(?_161178963)_(161193683_?)dup duplication not provided [RCV003113517] Chr1:161178963..161193683 [GRCh37]
Chr1:1q23.3		 uncertain significance
GRCh37/hg19 1q23.3(chr1:160778879-161190622)x3 copy number gain not provided [RCV002475740] Chr1:160778879..161190622 [GRCh37]
Chr1:1q23.3		 uncertain significance
NM_004106.2(FCER1G):c.23T>C (p.Leu8Pro) single nucleotide variant Inborn genetic diseases [RCV002679985] Chr1:161215344 [GRCh38]
Chr1:161185134 [GRCh37]
Chr1:1q23.3		 uncertain significance
GRCh37/hg19 1q23.1-23.3(chr1:158001058-162858285)x1 copy number loss not provided [RCV003483944] Chr1:158001058..162858285 [GRCh37]
Chr1:1q23.1-23.3		 likely pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:417
Count of miRNA genes:355
Interacting mature miRNAs:371
Transcripts:ENST00000289902, ENST00000367992, ENST00000490414
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
GDB:197000  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371161,186,116 - 161,186,266UniSTSGRCh37
Build 361159,452,740 - 159,452,890RGDNCBI36
Celera1134,253,268 - 134,253,418RGD
Cytogenetic Map1q23UniSTS
HuRef1132,543,064 - 132,543,216UniSTS
D1S2585  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371161,184,876 - 161,185,058UniSTSGRCh37
Build 361159,451,500 - 159,451,682RGDNCBI36
Celera1134,252,028 - 134,252,210RGD
Cytogenetic Map1q23UniSTS
HuRef1132,541,824 - 132,542,006UniSTS
RH70304  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371161,183,885 - 161,184,007UniSTSGRCh37
Build 361159,450,509 - 159,450,631RGDNCBI36
Celera1134,251,037 - 134,251,159RGD
Cytogenetic Map1q23UniSTS
HuRef1132,540,832 - 132,540,954UniSTS
GeneMap99-GB4 RH Map1581.83UniSTS
NCBI RH Map11441.6UniSTS
D1S3434  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371161,188,737 - 161,189,036UniSTSGRCh37
Build 361159,455,361 - 159,455,660RGDNCBI36
Celera1134,255,889 - 134,256,188RGD
Cytogenetic Map1q23UniSTS
HuRef1132,545,687 - 132,545,986UniSTS
Stanford-G3 RH Map16193.0UniSTS
GeneMap99-GB4 RH Map1588.36UniSTS
Whitehead-RH Map1719.1UniSTS
NCBI RH Map11441.4UniSTS
GeneMap99-G3 RH Map16149.0UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 465 470 1 9 3
Medium 2123 2109 1433 481 933 349 2879 1082 2037 303 880 1289 135 1 1201 1813 4 2
Low 253 409 282 135 472 105 1449 1101 1668 94 519 218 33 3 974 1
Below cutoff 59 8 11 8 57 11 25 14 29 20 46 86 6 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000289902   ⟹   ENSP00000289902
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1161,215,295 - 161,219,245 (+)Ensembl
RefSeq Acc Id: ENST00000367992   ⟹   ENSP00000356971
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1161,215,279 - 161,220,699 (+)Ensembl
RefSeq Acc Id: ENST00000490414
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1161,215,234 - 161,219,248 (+)Ensembl
RefSeq Acc Id: NM_004106   ⟹   NP_004097
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381161,215,295 - 161,219,245 (+)NCBI
GRCh371161,185,087 - 161,189,038 (+)ENTREZGENE
Build 361159,451,711 - 159,455,662 (+)NCBI Archive
HuRef1132,542,035 - 132,545,988 (+)ENTREZGENE
CHM1_11162,581,340 - 162,585,295 (+)NCBI
T2T-CHM13v2.01160,352,747 - 160,356,700 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_004097   ⟸   NM_004106
- Peptide Label: precursor
- UniProtKB: Q5VTW4 (UniProtKB/Swiss-Prot),   P30273 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000356971   ⟸   ENST00000367992
RefSeq Acc Id: ENSP00000289902   ⟸   ENST00000289902
Protein Domains
ITAM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P30273-F1-model_v2 AlphaFold P30273 1-86 view protein structure

Promoters
RGD ID:6785573
Promoter ID:HG_KWN:5841
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000367992,   NM_004106,   OTTHUMT00000083014,   UC001FZA.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361159,451,549 - 159,452,049 (+)MPROMDB
RGD ID:6857874
Promoter ID:EPDNEW_H2102
Type:initiation region
Name:FCER1G_2
Description:Fc fragment of IgE receptor Ig
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H2103  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381161,212,367 - 161,212,427EPDNEW
RGD ID:6857876
Promoter ID:EPDNEW_H2103
Type:initiation region
Name:FCER1G_1
Description:Fc fragment of IgE receptor Ig
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H2102  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381161,215,295 - 161,215,355EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:3611 AgrOrtholog
COSMIC FCER1G COSMIC
Ensembl Genes ENSG00000158869 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000289902 ENTREZGENE
  ENST00000289902.2 UniProtKB/Swiss-Prot
  ENST00000367992.7 UniProtKB/TrEMBL
GTEx ENSG00000158869 GTEx
HGNC ID HGNC:3611 ENTREZGENE
Human Proteome Map FCER1G Human Proteome Map
InterPro CD3_zeta/IgE_Fc_rcpt_gamma UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FCER1G UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Phos_immunorcpt_sig_ITAM UniProtKB/Swiss-Prot
KEGG Report hsa:2207 UniProtKB/Swiss-Prot
NCBI Gene 2207 ENTREZGENE
OMIM 147139 OMIM
PANTHER HIGH AFFINITY IMMUNOGLOBULIN EPSILON RECEPTOR SUBUNIT GAMMA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR16803 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ITAM UniProtKB/Swiss-Prot
  TCR_zetazeta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA28057 PharmGKB
PROSITE ITAM_1 UniProtKB/Swiss-Prot
SMART ITAM UniProtKB/Swiss-Prot
UniProt A6NCQ8_HUMAN UniProtKB/TrEMBL
  FCERG_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q5VTW4 ENTREZGENE
UniProt Secondary Q5VTW4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-11-08 FCER1G  Fc epsilon receptor Ig  FCER1G  Fc fragment of IgE receptor Ig  Symbol and/or name change 19259463 PROVISIONAL
2016-01-19 FCER1G  Fc fragment of IgE receptor Ig  FCER1G  Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide  Symbol and/or name change 5135510 APPROVED