CYP4A11 (cytochrome P450 family 4 subfamily A member 11) - Rat Genome Database

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Gene: CYP4A11 (cytochrome P450 family 4 subfamily A member 11) Homo sapiens
Analyze
Symbol: CYP4A11
Name: cytochrome P450 family 4 subfamily A member 11
RGD ID: 730831
HGNC Page HGNC:2642
Description: Enables monooxygenase activity. Involved in several processes, including icosanoid metabolic process; pressure natriuresis; and renal water homeostasis. Located in apical plasma membrane; cytoplasm; and intracellular membrane-bounded organelle. Implicated in hypertension.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: 20-HETE synthase; 20-hydroxyeicosatetraenoic acid synthase; alkane-1 monooxygenase; CP4Y; CYP4A2; CYP4AII; CYPIVA11; cytochrome P-450HK-omega; cytochrome P450 4A11; cytochrome P450, family 4, subfamily A, polypeptide 11; cytochrome P450, subfamily IVA, polypeptide 11; cytochrome P450HL-omega; fatty acid omega-hydroxylase; lauric acid omega-hydroxylase; long-chain fatty acid omega-monooxygenase; P450HL-omega
RGD Orthologs
Bonobo
Alliance Genes
More Info more info ...
Related Pseudogenes: CYP4A26P   CYP4A27P  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38146,929,188 - 46,941,476 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl146,929,177 - 46,941,484 (-)EnsemblGRCh38hg38GRCh38
GRCh37147,394,860 - 47,407,148 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36147,167,433 - 47,180,004 (-)NCBINCBI36Build 36hg18NCBI36
Build 34147,106,865 - 47,119,437NCBI
Celera145,682,030 - 45,694,343 (-)NCBICelera
Cytogenetic Map1p33NCBI
HuRef145,510,976 - 45,523,289 (-)NCBIHuRef
CHM1_1147,511,628 - 47,523,937 (-)NCBICHM1_1
T2T-CHM13v2.0146,806,597 - 46,818,885 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,4-naphthoquinone  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP)
19(S)-HETE  (EXP)
19-HETE  (EXP)
2-bromohexadecanoic acid  (EXP)
20-HETE  (EXP)
3-phenoxybenzoic acid  (EXP)
5-Hydroxythalidomide  (EXP)
acetylsalicylic acid  (EXP)
aflatoxin B1  (EXP)
all-trans-4-oxoretinoic acid  (EXP)
all-trans-retinoic acid  (EXP)
allopurinol  (EXP)
amphotericin B  (EXP)
arachidonic acid  (EXP)
Aroclor 1254  (EXP)
atrazine  (EXP)
benzo[a]pyrene  (EXP)
bezafibrate  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
cisplatin  (EXP)
clofibrate  (EXP)
diclofenac  (EXP)
dodecanoic acid  (EXP)
etodolac  (EXP)
fenofibrate  (EXP)
fipronil  (EXP)
flurbiprofen  (EXP)
GW 4064  (EXP)
GW 7647  (EXP)
Heliotrine  (EXP)
HET0016  (EXP)
hydrogen peroxide  (EXP)
ibuprofen  (EXP)
indometacin  (EXP)
isoliquiritigenin  (EXP)
isotretinoin  (EXP)
ketoprofen  (EXP)
Lasiocarpine  (EXP)
loxoprofen  (EXP)
mefenamic acid  (EXP)
methotrexate  (EXP)
N,N-diethyl-m-toluamide  (EXP)
N-acetyl-L-cysteine  (EXP)
N-Nitrosopyrrolidine  (EXP)
naproxen  (EXP)
nickel atom  (EXP)
O-methyleugenol  (EXP)
obeticholic acid  (EXP)
oleic acid  (EXP)
oxaprozin  (EXP)
perfluorobutanesulfonic acid  (EXP)
perfluorobutyric acid  (EXP)
perfluorododecanoic acid  (EXP)
perfluoroheptanoic acid  (EXP)
perfluorohexanoic acid  (EXP)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
perfluoroundecanoic acid  (EXP)
permethrin  (EXP)
phenobarbital  (EXP)
pirinixic acid  (EXP)
Pranoprofen  (EXP)
prostaglandin E2  (EXP)
salicylic acid  (EXP)
senecionine  (EXP)
Senkirkine  (EXP)
sodium arsenite  (EXP)
sulfluramid  (EXP)
sulindac  (EXP)
sulindac sulfide  (EXP)
sulindac sulfone  (EXP)
tebuconazole  (EXP)
trichostatin A  (EXP)
triclosan  (EXP)
valproic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. Contribution of cytochrome P450 4A isoforms to renal functional response to inhibition of nitric oxide production in the rat. Hercule HC, etal., J Physiol. 2003 Sep 15;551(Pt 3):971-9. Epub 2003 Jul 11.
3. Association of the T8590C polymorphism of CYP4A11 with hypertension in the MONICA Augsburg echocardiographic substudy. Mayer B, etal., Hypertension. 2005 Oct;46(4):766-71. Epub 2005 Sep 6.
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1739747   PMID:7679927   PMID:7798189   PMID:8274222   PMID:8363569   PMID:8914854   PMID:9618440   PMID:9799565   PMID:10024026   PMID:10660572   PMID:10860550   PMID:11139583  
PMID:11736898   PMID:11821421   PMID:12464261   PMID:12464262   PMID:12477932   PMID:15028279   PMID:15128046   PMID:15145985   PMID:15319333   PMID:15611369   PMID:16957555   PMID:18227405  
PMID:18300855   PMID:18385420   PMID:18391101   PMID:18433732   PMID:18484194   PMID:18574070   PMID:18624398   PMID:18660489   PMID:18936345   PMID:19343046   PMID:19366684   PMID:19615687  
PMID:19898482   PMID:20130494   PMID:21326303   PMID:21617944   PMID:21820496   PMID:21873635   PMID:21873888   PMID:21886157   PMID:21912424   PMID:22327816   PMID:22804341   PMID:23085321  
PMID:23376485   PMID:23859711   PMID:24164311   PMID:24278241   PMID:24535879   PMID:24816252   PMID:24931260   PMID:25064769   PMID:25203493   PMID:25734770   PMID:25760539   PMID:25947240  
PMID:26423716   PMID:26959478   PMID:27087514   PMID:27298316   PMID:27756246   PMID:27793475   PMID:28514442   PMID:28533430   PMID:28534704   PMID:29484037   PMID:30132788   PMID:32124935  
PMID:32141150   PMID:32373936  


Genomics

Comparative Map Data
CYP4A11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38146,929,188 - 46,941,476 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl146,929,177 - 46,941,484 (-)EnsemblGRCh38hg38GRCh38
GRCh37147,394,860 - 47,407,148 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36147,167,433 - 47,180,004 (-)NCBINCBI36Build 36hg18NCBI36
Build 34147,106,865 - 47,119,437NCBI
Celera145,682,030 - 45,694,343 (-)NCBICelera
Cytogenetic Map1p33NCBI
HuRef145,510,976 - 45,523,289 (-)NCBIHuRef
CHM1_1147,511,628 - 47,523,937 (-)NCBICHM1_1
T2T-CHM13v2.0146,806,597 - 46,818,885 (-)NCBIT2T-CHM13v2.0
CYP4A11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21179,788,627 - 179,883,014 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11178,930,336 - 179,024,732 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0146,228,434 - 46,240,736 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1147,583,019 - 47,594,927 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl147,583,564 - 47,594,870 (-)Ensemblpanpan1.1panPan2

Variants

.
Variants in CYP4A11
27 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1p34.3-33(chr1:39479787-47688131)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051817]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051817]|See cases [RCV000051817] Chr1:39479787..47688131 [GRCh38]
Chr1:39945459..48153803 [GRCh37]
Chr1:39718046..47926390 [NCBI36]
Chr1:1p34.3-33		 pathogenic
NM_000778.3(CYP4A11):c.927G>A (p.Lys309=) single nucleotide variant Malignant melanoma [RCV000060203] Chr1:46934337 [GRCh38]
Chr1:47400009 [GRCh37]
Chr1:47172596 [NCBI36]
Chr1:1p33		 not provided
NM_000778.3(CYP4A11):c.718G>A (p.Asp240Asn) single nucleotide variant Malignant melanoma [RCV000060204] Chr1:46935072 [GRCh38]
Chr1:47400744 [GRCh37]
Chr1:47173331 [NCBI36]
Chr1:1p33		 not provided
GRCh37/hg19 1p36.12-12(chr1:20608823-120546301)x3 copy number loss not provided [RCV000762767] Chr1:20608823..120546301 [GRCh37]
Chr1:1p36.12-12		 likely benign
GRCh37/hg19 1p34.1-32.3(chr1:45303358-52157856)x1 copy number loss See cases [RCV000448358] Chr1:45303358..52157856 [GRCh37]
Chr1:1p34.1-32.3		 likely pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
NM_000778.4(CYP4A11):c.731G>A (p.Ser244Asn) single nucleotide variant Inborn genetic diseases [RCV003243646] Chr1:46935059 [GRCh38]
Chr1:47400731 [GRCh37]
Chr1:1p33		 uncertain significance
GRCh37/hg19 1p33(chr1:47344057-47421549)x1 copy number loss not provided [RCV000684565] Chr1:47344057..47421549 [GRCh37]
Chr1:1p33		 uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p33(chr1:47305191-47416441)x3 copy number gain not provided [RCV000736483] Chr1:47305191..47416441 [GRCh37]
Chr1:1p33		 benign
GRCh37/hg19 1p36.22-21.1(chr1:103343285-103455144)x3 copy number gain Global developmental delay [RCV000787285] Chr1:103343285..103455144 [GRCh37]
Chr1:1p36.22-21.1		 uncertain significance
NM_000778.4(CYP4A11):c.337+9G>A single nucleotide variant not provided [RCV000901931] Chr1:46937987 [GRCh38]
Chr1:47403659 [GRCh37]
Chr1:1p33		 benign
NM_000778.4(CYP4A11):c.1461C>T (p.Ile487=) single nucleotide variant not provided [RCV000954841] Chr1:46930214 [GRCh38]
Chr1:47395886 [GRCh37]
Chr1:1p33		 benign
GRCh37/hg19 1p33-32.3(chr1:47272184-52505405)x1 copy number loss not provided [RCV001005086] Chr1:47272184..52505405 [GRCh37]
Chr1:1p33-32.3		 pathogenic
GRCh37/hg19 1p35.1-33(chr1:33285582-47891811) copy number gain not specified [RCV002052781] Chr1:33285582..47891811 [GRCh37]
Chr1:1p35.1-33		 pathogenic
GRCh37/hg19 1p34.1-32.3(chr1:45303358-52157856) copy number loss not specified [RCV002053281] Chr1:45303358..52157856 [GRCh37]
Chr1:1p34.1-32.3		 likely pathogenic
NM_000778.4(CYP4A11):c.1021C>A (p.Pro341Thr) single nucleotide variant Inborn genetic diseases [RCV002753396] Chr1:46934243 [GRCh38]
Chr1:47399915 [GRCh37]
Chr1:1p33		 uncertain significance
NM_000778.4(CYP4A11):c.259C>G (p.Pro87Ala) single nucleotide variant Inborn genetic diseases [RCV002946899] Chr1:46938074 [GRCh38]
Chr1:47403746 [GRCh37]
Chr1:1p33		 uncertain significance
NM_000778.4(CYP4A11):c.1474G>T (p.Ala492Ser) single nucleotide variant Inborn genetic diseases [RCV002882797] Chr1:46930201 [GRCh38]
Chr1:47395873 [GRCh37]
Chr1:1p33		 uncertain significance
NM_000778.4(CYP4A11):c.122G>A (p.Arg41Lys) single nucleotide variant Inborn genetic diseases [RCV002868521] Chr1:46941312 [GRCh38]
Chr1:47406984 [GRCh37]
Chr1:1p33		 uncertain significance
NM_000778.4(CYP4A11):c.509T>C (p.Leu170Pro) single nucleotide variant Inborn genetic diseases [RCV002703989] Chr1:46936665 [GRCh38]
Chr1:47402337 [GRCh37]
Chr1:1p33		 uncertain significance
NM_000778.4(CYP4A11):c.1154C>T (p.Pro385Leu) single nucleotide variant Inborn genetic diseases [RCV002757362] Chr1:46934014 [GRCh38]
Chr1:47399686 [GRCh37]
Chr1:1p33		 uncertain significance
NM_000778.4(CYP4A11):c.430C>T (p.Arg144Trp) single nucleotide variant Inborn genetic diseases [RCV002784808] Chr1:46936744 [GRCh38]
Chr1:47402416 [GRCh37]
Chr1:1p33		 uncertain significance
NM_000778.4(CYP4A11):c.548T>C (p.Leu183Pro) single nucleotide variant Inborn genetic diseases [RCV002641722] Chr1:46935610 [GRCh38]
Chr1:47401282 [GRCh37]
Chr1:1p33		 uncertain significance
NM_000778.4(CYP4A11):c.748C>T (p.Arg250Cys) single nucleotide variant Inborn genetic diseases [RCV002874475] Chr1:46935042 [GRCh38]
Chr1:47400714 [GRCh37]
Chr1:1p33		 uncertain significance
NM_000778.4(CYP4A11):c.1189G>T (p.Val397Phe) single nucleotide variant Inborn genetic diseases [RCV002827361] Chr1:46933979 [GRCh38]
Chr1:47399651 [GRCh37]
Chr1:1p33		 uncertain significance
NM_000778.4(CYP4A11):c.1067G>A (p.Gly356Asp) single nucleotide variant Inborn genetic diseases [RCV002891872] Chr1:46934197 [GRCh38]
Chr1:47399869 [GRCh37]
Chr1:1p33		 uncertain significance
NM_000778.4(CYP4A11):c.935G>A (p.Arg312His) single nucleotide variant Inborn genetic diseases [RCV002891392] Chr1:46934329 [GRCh38]
Chr1:47400001 [GRCh37]
Chr1:1p33		 uncertain significance
NM_000778.4(CYP4A11):c.1085C>T (p.Thr362Ile) single nucleotide variant Inborn genetic diseases [RCV002718199] Chr1:46934179 [GRCh38]
Chr1:47399851 [GRCh37]
Chr1:1p33		 uncertain significance
NM_000778.4(CYP4A11):c.1081A>C (p.Ile361Leu) single nucleotide variant Inborn genetic diseases [RCV002960245] Chr1:46934183 [GRCh38]
Chr1:47399855 [GRCh37]
Chr1:1p33		 uncertain significance
NM_000778.4(CYP4A11):c.1513C>G (p.Arg505Gly) single nucleotide variant Inborn genetic diseases [RCV002657011] Chr1:46930162 [GRCh38]
Chr1:47395834 [GRCh37]
Chr1:1p33		 uncertain significance
NM_000778.4(CYP4A11):c.268C>A (p.Leu90Ile) single nucleotide variant Inborn genetic diseases [RCV003339395] Chr1:46938065 [GRCh38]
Chr1:47403737 [GRCh37]
Chr1:1p33		 uncertain significance
NM_000778.4(CYP4A11):c.120C>T (p.His40=) single nucleotide variant not provided [RCV003406479] Chr1:46941314 [GRCh38]
Chr1:47406986 [GRCh37]
Chr1:1p33		 likely benign
Single allele inversion Bilateral polymicrogyria [RCV003459046] Chr1:33246132..61045156 [GRCh38]
Chr1:1p35.1-31.3		 likely pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3071
Count of miRNA genes:892
Interacting mature miRNAs:1016
Transcripts:ENST00000310638, ENST00000371904, ENST00000371905, ENST00000457840, ENST00000462347, ENST00000465874, ENST00000468629, ENST00000474458, ENST00000475477, ENST00000496519
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
SHGC-74786  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37147,395,718 - 47,395,861UniSTSGRCh37
Build 36147,168,305 - 47,168,448RGDNCBI36
Cytogenetic Map1p33UniSTS
HuRef145,511,851 - 45,511,994UniSTS
TNG Radiation Hybrid Map126072.0UniSTS
GeneMap99-GB4 RH Map1145.4UniSTS
SHGC-74787  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37147,608,330 - 47,608,464UniSTSGRCh37
GRCh37147,401,778 - 47,401,912UniSTSGRCh37
Build 36147,174,365 - 47,174,499RGDNCBI36
Celera145,688,968 - 45,689,102RGD
Cytogenetic Map1p33UniSTS
HuRef145,517,911 - 45,518,045UniSTS
HuRef145,723,985 - 45,724,119UniSTS
TNG Radiation Hybrid Map126082.0UniSTS
GeneMap99-GB4 RH Map1145.5UniSTS
RH122360  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37147,400,428 - 47,400,762UniSTSGRCh37
Build 36147,173,015 - 47,173,349RGDNCBI36
Cytogenetic Map1p33UniSTS
HuRef145,516,561 - 45,516,895UniSTS
TNG Radiation Hybrid Map126065.0UniSTS
GDB:226298  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37147,610,296 - 47,611,579UniSTSGRCh37
GRCh37147,398,678 - 47,399,964UniSTSGRCh37
Build 36147,171,265 - 47,172,551RGDNCBI36
Celera145,685,871 - 45,687,154RGD
Cytogenetic Map1p33UniSTS
HuRef145,514,811 - 45,516,097UniSTS
HuRef145,725,951 - 45,727,234UniSTS
SHGC-145153  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37147,405,528 - 47,405,838UniSTSGRCh37
Build 36147,178,115 - 47,178,425RGDNCBI36
Celera145,692,715 - 45,693,025RGD
Cytogenetic Map1p33UniSTS
HuRef145,521,661 - 45,521,971UniSTS
TNG Radiation Hybrid Map126046.0UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High 1 1 1 1
Medium 1 412 412 2 412 177 5 1
Low 193 130 75 22 109 22 928 11 631 77 93 95 1 540 442
Below cutoff 1884 2383 1081 162 671 5 3140 2018 2880 62 1108 1183 157 655 2297

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_007932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_000778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001319155 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001363587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_134988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_134989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_134990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_134991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_134992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_134993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_134994 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005270539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017000465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054334705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001737005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF525488 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK298267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK298413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL731892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY369778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC022851 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC041158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD013974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD013975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD013976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD013977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD013978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD013979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD013980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD014132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D13705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D26481 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L04751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S67580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S67581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X71480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000310638   ⟹   ENSP00000311095
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl146,929,188 - 46,941,476 (-)Ensembl
RefSeq Acc Id: ENST00000371904   ⟹   ENSP00000360971
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl146,929,180 - 46,941,456 (-)Ensembl
RefSeq Acc Id: ENST00000371905   ⟹   ENSP00000360972
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl146,932,431 - 46,941,464 (-)Ensembl
RefSeq Acc Id: ENST00000462347   ⟹   ENSP00000477495
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl146,929,637 - 46,941,464 (-)Ensembl
RefSeq Acc Id: ENST00000465874   ⟹   ENSP00000476368
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl146,931,506 - 46,941,476 (-)Ensembl
RefSeq Acc Id: ENST00000468629   ⟹   ENSP00000476619
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl146,930,048 - 46,941,484 (-)Ensembl
RefSeq Acc Id: ENST00000474458   ⟹   ENSP00000476988
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl146,930,048 - 46,941,484 (-)Ensembl
RefSeq Acc Id: ENST00000475477   ⟹   ENSP00000476854
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl146,929,177 - 46,941,484 (-)Ensembl
RefSeq Acc Id: ENST00000496519
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl146,933,915 - 46,934,246 (-)Ensembl
RefSeq Acc Id: NM_000778   ⟹   NP_000769
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38146,929,188 - 46,941,476 (-)NCBI
GRCh37147,394,846 - 47,407,156 (-)ENTREZGENE
GRCh37147,394,846 - 47,407,156 (-)NCBI
Build 36147,167,433 - 47,180,004 (-)NCBI Archive
HuRef145,510,976 - 45,523,289 (-)ENTREZGENE
CHM1_1147,511,628 - 47,523,937 (-)NCBI
T2T-CHM13v2.0146,806,597 - 46,818,885 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001319155   ⟹   NP_001306084
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38146,929,188 - 46,941,476 (-)NCBI
CHM1_1147,511,628 - 47,523,937 (-)NCBI
T2T-CHM13v2.0146,806,597 - 46,818,885 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001363587   ⟹   NP_001350516
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38146,929,188 - 46,941,476 (-)NCBI
T2T-CHM13v2.0146,806,597 - 46,818,885 (-)NCBI
Sequence:
RefSeq Acc Id: NR_134988
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38146,929,188 - 46,941,476 (-)NCBI
CHM1_1147,511,628 - 47,523,937 (-)NCBI
T2T-CHM13v2.0146,806,597 - 46,818,885 (-)NCBI
Sequence:
RefSeq Acc Id: NR_134989
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38146,929,188 - 46,941,476 (-)NCBI
CHM1_1147,511,628 - 47,523,937 (-)NCBI
T2T-CHM13v2.0146,806,597 - 46,818,885 (-)NCBI
Sequence:
RefSeq Acc Id: NR_134990
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38146,929,188 - 46,941,476 (-)NCBI
CHM1_1147,511,628 - 47,523,937 (-)NCBI
T2T-CHM13v2.0146,806,597 - 46,818,885 (-)NCBI
Sequence:
RefSeq Acc Id: NR_134991
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38146,929,188 - 46,941,476 (-)NCBI
CHM1_1147,511,628 - 47,523,937 (-)NCBI
T2T-CHM13v2.0146,806,597 - 46,818,885 (-)NCBI
Sequence:
RefSeq Acc Id: NR_134992
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38146,929,188 - 46,941,476 (-)NCBI
CHM1_1147,511,628 - 47,523,937 (-)NCBI
T2T-CHM13v2.0146,806,597 - 46,818,885 (-)NCBI
Sequence:
RefSeq Acc Id: NR_134993
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38146,929,188 - 46,941,476 (-)NCBI
CHM1_1147,511,628 - 47,523,937 (-)NCBI
T2T-CHM13v2.0146,806,597 - 46,818,885 (-)NCBI
Sequence:
RefSeq Acc Id: NR_134994
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38146,929,188 - 46,941,476 (-)NCBI
CHM1_1147,511,628 - 47,523,937 (-)NCBI
T2T-CHM13v2.0146,806,597 - 46,818,885 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005270539   ⟹   XP_005270596
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38146,932,757 - 46,941,476 (-)NCBI
GRCh37147,394,846 - 47,407,156 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017000465   ⟹   XP_016855954
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38146,929,188 - 46,940,816 (-)NCBI
Sequence:
RefSeq Acc Id: XM_054334705   ⟹   XP_054190680
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0146,806,597 - 46,818,224 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_000769   ⟸   NM_000778
- Peptide Label: isoform 1
- UniProtKB: Q86SU6 (UniProtKB/Swiss-Prot),   Q5VSP8 (UniProtKB/Swiss-Prot),   Q16866 (UniProtKB/Swiss-Prot),   Q16865 (UniProtKB/Swiss-Prot),   Q06766 (UniProtKB/Swiss-Prot),   Q8IWY5 (UniProtKB/Swiss-Prot),   Q02928 (UniProtKB/Swiss-Prot),   Q16802 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005270596   ⟸   XM_005270539
- Peptide Label: isoform X2
- UniProtKB: A5PL05 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001306084   ⟸   NM_001319155
- Peptide Label: isoform 2
- UniProtKB: Q16802 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016855954   ⟸   XM_017000465
- Peptide Label: isoform X1
- UniProtKB: B4DPB8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001350516   ⟸   NM_001363587
- Peptide Label: isoform 3
- UniProtKB: V9GZ77 (UniProtKB/TrEMBL),   A5PL05 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSP00000360971   ⟸   ENST00000371904
RefSeq Acc Id: ENSP00000360972   ⟸   ENST00000371905
RefSeq Acc Id: ENSP00000476368   ⟸   ENST00000465874
RefSeq Acc Id: ENSP00000476619   ⟸   ENST00000468629
RefSeq Acc Id: ENSP00000311095   ⟸   ENST00000310638
RefSeq Acc Id: ENSP00000476988   ⟸   ENST00000474458
RefSeq Acc Id: ENSP00000476854   ⟸   ENST00000475477
RefSeq Acc Id: ENSP00000477495   ⟸   ENST00000462347
RefSeq Acc Id: XP_054190680   ⟸   XM_054334705
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q02928-F1-model_v2 AlphaFold Q02928 1-519 view protein structure

Promoters
RGD ID:6855452
Promoter ID:EPDNEW_H891
Type:initiation region
Name:CYP4A11_1
Description:cytochrome P450 family 4 subfamily A member 11
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38146,941,476 - 46,941,536EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:2642 AgrOrtholog
COSMIC CYP4A11 COSMIC
Ensembl Genes ENSG00000187048 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000310638 ENTREZGENE
  ENST00000310638.9 UniProtKB/Swiss-Prot
  ENST00000371905.1 UniProtKB/TrEMBL
  ENST00000462347 ENTREZGENE
  ENST00000462347.5 UniProtKB/TrEMBL
  ENST00000465874.5 UniProtKB/TrEMBL
  ENST00000468629.5 UniProtKB/TrEMBL
  ENST00000474458.5 UniProtKB/TrEMBL
  ENST00000475477 ENTREZGENE
  ENST00000475477.5 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000187048 GTEx
HGNC ID HGNC:2642 ENTREZGENE
Human Proteome Map CYP4A11 Human Proteome Map
InterPro Cyt_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-II UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:1579 UniProtKB/Swiss-Prot
NCBI Gene 1579 ENTREZGENE
OMIM 601310 OMIM
PANTHER CYTOCHROME P450 4A11-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CYTOCHROME P450 FAMILY 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam p450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA27118 PharmGKB
PRINTS EP450I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EP450II UniProtKB/TrEMBL
  P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0C4DFV7_HUMAN UniProtKB/TrEMBL
  A5PL05 ENTREZGENE
  B4DPB8 ENTREZGENE, UniProtKB/TrEMBL
  CP4AB_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q06766 ENTREZGENE
  Q16802 ENTREZGENE, UniProtKB/TrEMBL
  Q16865 ENTREZGENE
  Q16866 ENTREZGENE
  Q5VSP8 ENTREZGENE
  Q86SU6 ENTREZGENE
  Q8IWY5 ENTREZGENE
  V9GY41_HUMAN UniProtKB/TrEMBL
  V9GYC6_HUMAN UniProtKB/TrEMBL
  V9GYK4_HUMAN UniProtKB/TrEMBL
  V9GYQ2_HUMAN UniProtKB/TrEMBL
  V9GZ77 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q06766 UniProtKB/Swiss-Prot
  Q16865 UniProtKB/Swiss-Prot
  Q16866 UniProtKB/Swiss-Prot
  Q5VSP8 UniProtKB/Swiss-Prot
  Q86SU6 UniProtKB/Swiss-Prot
  Q8IWY5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-15 CYP4A11  cytochrome P450 family 4 subfamily A member 11  CYP4A11  cytochrome P450, family 4, subfamily A, polypeptide 11  Symbol and/or name change 5135510 APPROVED